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Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticPaired Box Transcription FactorsPAX2 Transcription FactorSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceHomeodomain ProteinsTranscriptional ActivationBinding SitesTrans-ActivatorsRepressor ProteinsBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerNuclear ProteinsProtein BindingGene Expression Regulation, DevelopmentalTranscription Factor AP-1PAX7 Transcription FactorForkhead Transcription FactorsCell LineSignal TransductionAmino Acid SequenceDNAMutationBasic-Leucine Zipper Transcription FactorsCell DifferentiationTranscription Factor AP-2PAX9 Transcription FactorCell NucleusTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIGenes, ReporterChromatin ImmunoprecipitationHeLa CellsYY1 Transcription FactorCells, CulturedSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDReverse Transcriptase Polymerase Chain ReactionActivating Transcription Factor 3NFATC Transcription FactorsTranscription Initiation SiteElectrophoretic Mobility Shift AssaySp3 Transcription FactorEnhancer Elements, GeneticNF-kappa BZinc FingersActivating Transcription Factor 2Transcription Factor TFIIBRegulatory Sequences, Nucleic AcidGene Expression ProfilingCloning, MolecularE2F1 Transcription FactorRNA Polymerase IIRecombinant Fusion ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPlasmidsMEF2 Transcription FactorsGene ExpressionGATA3 Transcription FactorMicrophthalmia-Associated Transcription FactorTCF Transcription FactorsGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalGATA Transcription FactorsProtein Structure, TertiaryLuciferasesB-Cell-Specific Activator ProteinSTAT1 Transcription FactorActivating Transcription FactorsCell Line, TumorEye ProteinsChromatinPhosphorylationHelix-Loop-Helix MotifsTranscription Factor RelAOligonucleotide Array Sequence AnalysisE2F Transcription FactorsModels, BiologicalSequence Homology, Amino AcidSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMice, KnockoutGene Expression Regulation, PlantTranscription Factor 7-Like 1 ProteinMice, TransgenicGATA6 Transcription FactorActivating Transcription Factor 4Activating Transcription Factor 1Blotting, WesternCyclic AMP Response Element-Binding ProteinProto-Oncogene ProteinsIn Situ Hybridization
PAX3ProteinEmbryonicPAX6 Transcription FactorDifferentiationExpressionProteinsMyogenicSelf-renewalGenesStem cellsMiceMyofiberSkeletal muscleGeneticPhosphorylationLarvalVivoFunctionalTeadNeuralCellsGenomeDevelopmentRoleInteractionCytokineDiscoverySatelliteBFGFEpidermalCellImportantEnhancerLevelsTissueBiologicalFamilyPioneer
PAX33
  • Aberrant PAX3 and PAX7 expression. (wikipedia.org)
  • 2007 ). During this process, cells from the anterior area of the somite that specific the transcription factors Pax3 and Pax7 change into positioned exterior to the slow muscle within the exterior cell layer (ECL), which has traits of the amniote dermomyotome ( Hollway et al. (wijvallenaf.nl)
  • Facial and somatic muscle development is controlled by different transcription factors: PITX2 for facial muscles, and PAX3 and PAX7 for somatic muscles, suggesting the possibility that the FSHD disease gene, DUX4, is regulated and functions differently in facial and somatic muscles and will be responsive to different therapeutics. (fshfriends.org)
Protein10
  • Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene. (wikipedia.org)
  • Muscle stem cell from young mouse stained with the transcription factor Pax7 and in contact with the muscle fibre through the extracellular matrix protein M-Cadherin. (pasteur.fr)
  • Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. (umassmed.edu)
  • The encoded protein is likely to be a nuclear transcription factor. (nih.gov)
  • The basic fibroblast growth factor (bFGF) is a member of the fibroblast growth factor family and is a key protein in regenerative medicine. (biomedcentral.com)
  • The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
  • Cyclin/Cdk repression inhibits retinoblastoma protein (pRb) phosphorylation, thereby limiting the transcription of genes that directly promote the mechanics of the cell cycle, and we found that Pax6 inhibits pRb phosphorylation and represses genes involved in DNA replication. (ox.ac.uk)
  • We demonstrate enrichment of RUNT family transcription-factor-binding motifs in human epidermal CD8+CD103+CD49a+ TRM cells, paralleled by high RUNX2 and RUNX3 protein expression. (scilifelab.se)
  • The data establishing a continuum of SCs and the relationship to Pax7 protein levels can largely be eliminated and referenced by the two former manuscripts. (sciety.org)
  • Moreterminated, Pax7-DS and DD mutants revealed a affinity toity towards higher protein utterance, alalthough statistical significance was not achieved exactly to the variability inherent to impermanent transfections. (upb.ro)
Embryonic3
  • A predictive model of bifunctional transcription factor signaling during embryonic tissue patterning. (umassmed.edu)
  • Thus, we have sought to identify genes targeted by Pax7 during embryonic development using an unbiased chromatin immunoprecipitation (ChIP) cloning assay to isolate cis-regulatory regions bound by Pax7 in vivo. (edu.au)
  • This analysis gives us greater insight into the direct functional role played by Pax7 during embryonic development. (edu.au)
PAX6 Transcription Factor3
  • PAX6 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • This graph shows the total number of publications written about "PAX6 Transcription Factor" by people in this website by year, and whether "PAX6 Transcription Factor" was a major or minor topic of these publications. (jefferson.edu)
  • Below are the most recent publications written about "PAX6 Transcription Factor" by people in Profiles. (jefferson.edu)
Differentiation7
  • Their fate is regulated by the expression of various transcription factors, including paired box 7 (Pax7) and myogenic differentiation (MyoD) [ 6 ]. (biomedcentral.com)
  • Develop transcription factor over-expression in combination with improved directed differentiation strategies to generate MuSCs from hPSCs with genetic and functional signatures of the in vivo MuSCs. (ca.gov)
  • Persistent expression of C/EBPβ upregulates Pax7, inhibits MyoD, and blocks myogenic differentiation. (biomedcentral.com)
  • CCAAT/enhancer binding proteins (C/EBPs) are a family of transcription factors that regulate cellular growth and differentiation, metabolism, and inflammation [ 18 ]. (biomedcentral.com)
  • For example, these manuscripts establish that elevated Pax7 levels drive quiescence and low Pax7 levels correlate with differentiation. (sciety.org)
  • Induction of antisense Pax-3 expression leads to the rapid morphological differentiation of neuronal cells and an altered response to the mitogenic growth factor bFGF. (jefferson.edu)
  • Constitutive expression of Yap maintains Pax7 + and MyoD + satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. (kcl.ac.uk)
Expression11
  • Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. (wikipedia.org)
  • To assess the capacity of Pax7 to regulate transcription from these loci, we have cloned alternate transcripts of Pax7 (differing significantly in their DNA binding domain) into expression vectors and transfected cultured cells with these constructs, then analyzed target gene expression levels using RT-PCR. (edu.au)
  • Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
  • The antioxidant imbalance and expression of Zebrafish 2, mtnr1ba and pax7 in zebrafish fish embryos decreased. (aclumengine.com)
  • The mechanisms by which early spatiotemporal expression patterns of transcription factors such as Pax6 regulate cortical progenitors in a region-specific manner are poorly understood. (ox.ac.uk)
  • One significant issue with the manuscript is the "discovery" of an SC continuum related to the relative levels of Pax7 expression. (sciety.org)
  • In the original manuscript we acknowledged that SCs exist on a continuum-a gradual transition from one state to another, based on scRNA-seq studies and the present data (Dll4, Pax7 and Ddx6 expression). (sciety.org)
  • Despite its cellular simplicity (five pairs of neurons), the MG exhibits conservation of transcription factor expression with the spinal cord of vertebrates. (biologists.com)
  • Sonic Hedgehog (Shh) signaling helps pattern the vertebrate neural tube, in part by regulating the dorsal/ventral expression of a number of homeodomain containing transcription factors. (zfin.org)
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • By contrast, transforming growth factor (TGF)-β1 was demonstrated to markedly downregulate HGF gene expression ( 10 , 11 ). (spandidos-publications.com)
Proteins3
  • Transcription is the process by which genes carried by DNA are encoded in another form (RNA), this RNA is then translated into proteins. (pasteur.fr)
  • Drouin's team now plan to investigate Pax7 in more detail and identify the proteins that interact with it to open up compacted parts of the genome, which Drouin says could lead to the development of therapeutic targets. (blogspot.com)
  • Cytokines are a family of cell signaling proteins that include Chemokines, Interleukins, Tumor Necrosis Factors (TNFs), Transforming Growth Factors (TGFs), Inter ferons, and Colony Stimulating Factors (CSFs). (pharna.com)
Myogenic2
  • The quiescent muscle stem cell (QSC) pool is heterogeneous and generally characterized by the presence and levels of intrinsic myogenic transcription factors. (sciety.org)
  • Pax7 is required for the specification of myogenic satellite cells. (medecinesciences.org)
Self-renewal1
  • Finally, we show that template DNA cosegregates with Numb in label-retaining cells that express the self-renewal marker Pax7. (nih.gov)
Genes4
  • Sequencing and genomic localization of a library of chromatin-DNA fragments bound by Pax7 has identified 34 candidate Pax7 target genes, with occupancy of a selection confirmed with independent chromatin enrichment tests (ChIP-PCR). (edu.au)
  • We show that Pax7 directly occupies sites within genes encoding transcription factors Gbx1 and Eya4, the neurogenic cytokine receptor ciliary neurotrophic factor receptor, the neuronal potassium channel Kcnk2, and the signal transduction kinase Camk1d in vivo and regulates the transcriptional state of these genes in cultured cells. (edu.au)
  • For transcription factors to be able to perform this function, they need access to the necessary genes at the right time. (blogspot.com)
  • Finally, we confirm in myoblasts that Yap binds to Tead transcription factors and co-activates MCAT elements which are enriched in the proximal promoters of Yap-responsive genes. (kcl.ac.uk)
Stem cells4
  • PAX7 functions as a marker for a rare subset of spermatogonial stem cells, specifically a sub set of Asingle spermatogonia. (wikipedia.org)
  • Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription. (umassmed.edu)
  • PKU19F_G03_04 - Functional analysis of the transcription factor Pax7 in mouse muscle stem cells. (gao-lab.org)
  • PKU19F_G12_13 - Functional analysis of the transcription factor Pax7 in mouse muscle stem cells. (gao-lab.org)
Mice2
  • However, PAX7 is not required for spermatogenesis, as mice without PAX7+ spermatogonia show no deficits in fertility. (wikipedia.org)
  • Additionally, mice lacking PAX7 had delayed recovery of spermatogenesis following exposure to busulfan when compared to control mice. (wikipedia.org)
Myofiber1
  • The identification of heterogenous distribution of factors across the myofiber is an important contribution for dissecting how muscle stem cell diversity in a tissue is achieved. (sciety.org)
Skeletal muscle1
  • Pax7 plays critical roles in development of brain, spinal cord, neural crest, and skeletal muscle. (edu.au)
Genetic1
  • Transcription factors help this genetic information be copied into RNA at various stages throughout a person's development, including the production of new cells. (blogspot.com)
Phosphorylation1
Larval1
  • 2007 ). In some species the ECL disappears throughout the early larval levels, by which time a resident population of Pax7-expressing cells is present throughout the myotome ( Marschallinger et al. (wijvallenaf.nl)
Vivo1
  • We will identify unique cell surface markers on in vivo derived MuSCs that distinguish PAX7-positive cells from other muscle cells and across cell states. (ca.gov)
Functional2
  • As a sequence-specific DNA-binding transcription factor, any direct functional role played by Pax7 during development is mediated through target gene selection. (edu.au)
  • Bouchard M, Pfeffer P, Busslinger M. Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development. (medecinesciences.org)
Tead1
  • Tead and AP1 Coordinate Transcription and Motility. (umassmed.edu)
Neural1
  • Pax7 plays an important role in the development of neural processes, especially in the process of yellow Tuan pigmentation. (aclumengine.com)
Cells4
  • Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. (wikipedia.org)
  • To find out how this might be achieved, Professor Jacques Drouin and team looked at two types of pituitary cells that seem to develop using the same transcription factors. (blogspot.com)
  • One such alternative cell fate is the adipogenic fate as Pax7(+) satellite cells isolated from solitary myofibers used adipogenic fate in addition ARHGAP1 to muscle mass fate significance of these factors we used a mouse fracture healing model inside a genetically altered reporter mouse where muscle mass progenitors were lineage-traced. (healthyguide.info)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
Genome1
  • In a new study, researchers at the Université de Montréal have discovered a molecule called Pax7 that opens up parts of the compacted genome, enabling access by transcription factors. (blogspot.com)
Development2
  • Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. (umassmed.edu)
  • A paired box transcription factor that has important functions in the development of the eye, nose, central nervous system and pancreas. (jefferson.edu)
Role2
  • Pax7 is a transcription factor that plays a role in theformation of skeletal muscular tissue, and expressed in the palatal shelf ofthe maxilla. (thespecialsmiles.com)
  • The team focused on the Pax7 molecule and were able to demonstrate the crucial role it performs. (blogspot.com)
Interaction1
  • the interaction links PAX7 to a WDR5-containing histone methyltransferase complex By similarity. (wikipedia.org)
Cytokine2
  • Type I Cytokine Receptors include interleukin receptors, colony stimulating factor receptors, and hormone receptors whereas Type II Cytokine Receptors include inter feron receptors and cytokine receptors that bind to interleukin-10 family. (pharna.com)
  • cardiotrophin like cytokine factor 1 [So. (gsea-msigdb.org)
Discovery1
  • Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. (umassmed.edu)
Satellite1
  • Here, we identify the transcriptional co-factor Yap as a novel regulator of satellite cell fate decisions. (kcl.ac.uk)
BFGF1
  • Research on regenerative medicine using basic fibroblast growth factor (bFGF) has recently advanced in the field of laryngology. (biomedcentral.com)
Epidermal1
Cell2
  • In melanoma patients, high RUNX2, but not RUNX3, transcription correlated with a cytotoxic CD8+CD103+CD49a+ TRM cell signature and improved patient survival. (scilifelab.se)
  • Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program. (uiowa.edu)
Important1
  • Artificial lighting pollution has the potential to become an important risk factor for different diseases, including cancer, so more research should be carried out and necessary provisions should be made on this risk factor. (aclumengine.com)
Enhancer1
  • Suppression of glycogen synthase kinase activity is not sufficient for leukemia enhancer factor-1 activation. (umassmed.edu)
Levels1
  • The abundance of Dll4 captured by the QSC correlates with levels of the SC identity gene, Pax7. (sciety.org)
Tissue1
Biological1
  • Sunlight is a major factor in maintaining the biological clock and regulating the circadian rhythm of all organisms. (aclumengine.com)
Family2
  • Finally, the Tumor Necrosis Factor Receptor Family include immune checkpoint molecules such as CD27, tumor markers such as CD30, and co-stimulatory molecules such as CD40. (pharna.com)
  • The developmental processes affected by the Intu mutation are under the control of Hh signaling through Gli-family transcription factors. (psu.edu)
Pioneer1