• To investigate the frequency of azoospermia factor (AZF) deletions in Dutch patients with testicular germ cell tumors (TGCTs). (nih.gov)
  • For children with extracranial germ cell tumors, surgery is an essential component of treatment. (medscape.com)
  • In the United States, the standard chemotherapy regimen for both adults and children with malignant nonseminomatous germ cell tumors includes cisplatin, etoposide, and bleomycin (PEB). (medscape.com)
  • The combination of carboplatin, etoposide, and bleomycin has been studied in the United Kingdom but has not been compared with PEB in a trial focusing on pediatric germ cell tumors. (medscape.com)
  • Pavone et al, analyzing data from the French TGM95 study, suggested that in intermediate-risk children with ovarian nonseminomatous germ cell tumors, a low-intensive etoposide-free VBP (vinblastin-bleomycin-cisplatin) regimen could be a treatment alternative. (medscape.com)
  • Bilateral malignant tumors require bilateral oophorectomy, but hysterectomy is unnecessary for germ cell tumors. (medscape.com)
  • Among the different stages of germ cell tumors, pure seminomas tend to be treated one way, and non-seminomas and mixed germ cell tumors are treated another way. (cancer.org)
  • 1 Zagreb University Hospital Centre, Department of Oncology, Division of Medical Oncology, Unit of Uro-oncology, Referral Center for Treatment of Germ Cell Tumors and Extragonadal Germ Cell Tumors of the Ministry of Health of the Republic of Croatia, Zagreb, Croatia. (nih.gov)
  • 8. [HLA antigens in patients with testicular germ cell tumors]. (nih.gov)
  • 11. testicular tumors occurring in non-twin brothers: a case report. (nih.gov)
  • 3) accumulation of mutations in these cells will lead to testicular tumors or male infertility. (mdanderson.org)
  • The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
  • [ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • Controversy remains regarding the origin of extragonadal germ cell tumors. (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • According to this theory, the differences in phenotypes expressed by mediastinal germ cell tumors (MGCTs) and gonadal germ cell tumors may be explained by differences in the cellular environment between the gonad and the anterior mediastinum. (medscape.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
  • Testicular germ cell tumors (TGCT) are the most commonly diagnosed cancers amongst young men. (qxmd.com)
  • Testicular choriocarcinoma is one of the histologic types of nonseminomatous germ cell tumors (NSGCTs), which along with testicular seminoma constitute the two major histologic groups of testicular cancers. (medscape.com)
  • Like other germ cell tumors (GCTs), choriocarcinoma typically affects younger men. (medscape.com)
  • In a histologic review of 1010 orchiectomies from 1999 to 2011 from a single Mexican oncology institution, 0.6% were pure choriocarcinomas and 0.9% were mixed germ cell tumors with a predominant choriocarcinoma component. (medscape.com)
  • In a literature review of 10,000 cases of germinal testicular cell tumors, Ramon y Cajal et al found 54 (0.5%) cases of pure choriocarcinoma. (medscape.com)
  • Newswise - PHILADELPHIA-A meta-analysis of nearly 200,000 men revealed 22 new genetic locations that could be susceptible to inherited testicular germ cell tumors (TGCT) - a 40 percent increase in the number of regions known to be associated with the cancer. (newswise.com)
  • Germ cell tumors account for 95 percent of testicular cancer cases. (newswise.com)
  • Nathanson and TECAC teams have used the method to find locations on chromosomes - called loci - that contain variants associated with an increased risk of germ cell tumors. (newswise.com)
  • Although these strategies provide efficacy and effective actions in making enduring relief in patients with nonmetastatic and early cancers, they are usually unsuccessful in producing long-lasting benefits in patients with late-stage disease, except in certain leukemias, lymphomas, germ cell tumors, and testicular carcinomas. (hindawi.com)
  • It is a subtype of germ cell tumors representing less than one percent of testicular non-seminomatous germ cell tumors (NSGCT). (iuhealth.org)
  • Led by Dr. Frederick Locke , Moffitt's Blood and Marrow Transplant and Cellular Immunotherapy (BMT CI) Program serves patients with a number of hematological conditions, including leukemia, lymphoma, multiple myeloma, aplastic anemia, and myelodysplastic syndrome (MDS), myelofibrosis, sickle cell, as well as select solid tumors such as germ cell tumor (or testicular cancer. (moffitt.org)
  • Provides information about testicular and germ cell tumors. (oncolink.org)
  • Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis. (cdc.gov)
  • To assess retrospectively the long-term cancer control in patients undergoing laparoscopic retroperitoneal lymph node dissection (RPLND) in the management of clinical Stage I nonseminomatous germ cell testicular tumors. (wustl.edu)
  • Germ cell tumors of the testis are the most common cancer in young men between the ages of 15 and 35 years. (health.am)
  • Germ cell tumors of the testis represent greater than 90% of all tumors of the testis. (health.am)
  • These tumors appear to arise from a pluripotent germ cell capable of differentiating into embryonic structures (teratoma and embryonal carcinoma), placental structures (yolk-sac tumor and choriocarcinoma) or seminoma (the most primitive germ cell tumor). (health.am)
  • Other malignancies of the testis include lymphoma (the most common non-germ cell cause of testicular malignancy in elderly men), metastatic cancer or leukemia, tumors of the testicular stroma, and other rare tumors. (health.am)
  • Occasionally extragonadal germ cell tumors may present within the mediastinum or retroperitoneum without an identifiable testicular tumor. (health.am)
  • Ultrasonography of the testes should be performed in the event that there is doubt about which testis may harbor the tumor, that bilateral tumors are suspected, or that there is an extragonadal presentation of a germ cell tumor. (health.am)
  • The availability of sensitive serum assays for α fetoprotein (AFP) and for the β-subunit of human chorionic gonadotropin (β-HCG) has markedly enhanced the accurate and aggressive management of patients with germ cell tumors. (health.am)
  • UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells - the cells that develop into sperm and eggs. (ucla.edu)
  • Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer. (ucla.edu)
  • Germ cell tumors most often develop during embryonic development, in the testes and ovaries, but they can also occur in the spine, chest and brain when germ cells mistakenly migrate there. (ucla.edu)
  • There are five subtypes of germ cell tumors: germinomas, embryonal carcinomas, yolk sac tumors, choriocarcinomas and teratomas. (ucla.edu)
  • For the new work, Clark teamed up with Dr. Joanna Gell, a UCLA pediatric cancer specialist who had become interested in germ cell tumors a few years ago, when she was a clinical fellow helping to care for a teenage girl with a hard-to-treat case. (ucla.edu)
  • The treatments we have are relatively effective in curing germ cell tumors, but they come with a whole host of serious side effects," Gell said. (ucla.edu)
  • The researchers also analyzed samples of germ cell tumors from patients and found evidence of PRDM14 protein in embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors - but not in teratomas, which suggests that the protein could be a marker pathologists could use to better characterize the type of tumor. (ucla.edu)
  • This proves that the PRDM14 protein is abnormally expressed in germ cell tumors, and therefore a possible therapeutic target. (ucla.edu)
  • The research won't lead immediately to a new treatment for germ cells tumors, because no drugs currently exist that can shut off PRDM14. (ucla.edu)
  • But the techniques the scientists used should pave the way toward additional studies on the molecular details of germ cell tumors. (ucla.edu)
  • Clark and Gell are planning to take skin cells from people with germ cell tumors, reprogram those cells into induced pluripotent stem cells and then generate PGCs, which would recreate each patient's tumor cells in the lab for further testing. (ucla.edu)
  • In mice, the substance kills degenerated cells and allows testicular tumors to shrink. (bionity.com)
  • In a testicular cancer mouse model, the tumors began to shrink after administering JQ1," explains the lead author of the study, Sina Jostes. (bionity.com)
  • Such a combination therapy to treat testicular tumors may be much better tolerated. (bionity.com)
  • Guo CC, Punar M, Contreras AL, Tu SM, Pisters LL, Tamboli P. Czerniak B . Testicular germ cell tumors with saracomatous components: an analysis of 33 cases. (mdanderson.org)
  • 1 The most common types of cancer diagnosed in 15- to 19-year-olds are lymphomas, followed by brain and other central nervous system tumors, leukemias, gonadal (testicular and ovarian) germ cell tumors, thyroid cancer, and melanoma. (oncologynurseadvisor.com)
  • Bone marrow aspirate, conducted to diagnose a cause of pancytopenia, revealed metastatic germ cell tumors in the bone marrow. (bvsalud.org)
  • Conclusion: Bone marrow metastasis should be considered as a differential diagnosis in patients with germ cell tumors whose serum tumor makers are not normalized without any radiographic finding of recurrence. (bvsalud.org)
  • Age-incidence profiles for extracranial, extragonadal germ cell tumors (left graph) and for gonadal germ cell tumors (right graph). (kaiserpermanente.org)
  • Twenty-nine patients in the study had mediastinal primary tumors, and nine patients (31%) had Klinefelter syndrome. (kaiserpermanente.org)
  • accordingly, the majority of such masses are germ cell tumors. (medconsonline.com)
  • Germs cell tumors are further divided into seminomas (slow-growing type) and non-seminomas (that are more aggressive). (medconsonline.com)
  • Blood tests aimed at looking for specific tumor markers (proteins which are released by testicular tumors in varying amounts depending on their type and stage) give significant information both in terms of primary diagnostics and follow-up case monitoring. (medconsonline.com)
  • The majority of them are germ cell tumors which fall into seminomas and non-seminomas. (medconsonline.com)
  • Testicular Microlithiasis: Is It Linked with Testicular Cancer? (medlineplus.gov)
  • All patients had clinical Stage I nonseminomatous germ cell testicular tumor, with vascular invasion and/or embryonal carcinoma in the orchiectomy specimen. (wustl.edu)
  • Laparoscopic RPLND is a safe, minimally invasive treatment option in patients with clinical Stage I nonseminomatous germ cell testicular tumor. (wustl.edu)
  • Platinum-based chemotherapy is highly efficacious for treating invasive and metastatic testicular cancer, but is less so for ITGCN. (medscape.com)
  • Among 60 patients with metastatic testicular cancer who had received treatment with platinum-based combination chemotherapy followed by orchiectomy, persistent ITGCN in the tumor-bearing testis was found in 8% of cases. (medscape.com)
  • [ 14 ] The 5-year incidence of subsequent contralateral testicular cancer was significantly lower in the chemotherapy group than in the radiation group. (medscape.com)
  • Even though the patient in the present case had received adjuvant chemotherapy, the risk of the ITGCN in his left testis progressing to invasive testicular cancer was considered high enough to warrant further local treatment. (medscape.com)
  • Testosterone replacement therapy is an important part of comprehensive care for patients who have been treated for testicular cancer. (medscape.com)
  • This study is a retrospective analysis of testicular cancer patients from 2014 to 2020 who have received salvage chemotherapy treatment at Tata Memorial Centre. (ecancer.org)
  • A total of 46 testicular cancer patients from 2014 to 2020, who received second-line chemotherapy, were analysed from the database maintained at our hospital. (ecancer.org)
  • We connect patients, caregivers, and family members with essential services and resources at every step of their cancer journey. (cancer.org)
  • Treatment for testicular cancer is based mainly on the type and stage of the cancer. (cancer.org)
  • The cancer will come back in about 15% to 20% of patients, most often as spread to lymph nodes, but if it does, radiation or chemo can still usually cure the cancer. (cancer.org)
  • Recent case-control studies suggested that dairy product consumption is an important risk factor for testicular cancer. (aacrjournals.org)
  • We examined the association between consumption of dairy products, especially milk, milk fat, and galactose, and testicular cancer in a population-based case-control study including 269 case and 797 controls (response proportions of 76% and 46%, respectively). (aacrjournals.org)
  • The RR of testicular cancer was 1.37 (95% CI, 1.12-1.68) per additional 20 servings of milk per month (each 200 mL) in adolescence. (aacrjournals.org)
  • Our results suggest that milk fat and/or galactose may explain the association between milk and dairy product consumption and seminomatous testicular cancer. (aacrjournals.org)
  • Testicular cancer is a rare disease. (aacrjournals.org)
  • Several studies focusing on exposures during childhood or even during the prenatal and perinatal periods indicate that carcinogenic effects most likely act very early in life and therefore result in the unusual young adult incidence peak of testicular cancer ( 3, 4 ). (aacrjournals.org)
  • Cryptorchidism and a familial history of testicular cancer are among the best established risk factors of testicular cancer ( 5 ). (aacrjournals.org)
  • What is testicular cancer? (medlineplus.gov)
  • Testicular cancer is a cancer that develops in the tissues of one or both testicles. (medlineplus.gov)
  • Who is most likely to develop testicular cancer? (medlineplus.gov)
  • Testicular cancer is very rare. (medlineplus.gov)
  • What are the symptoms of testicular cancer? (medlineplus.gov)
  • How is testicular cancer diagnosed? (medlineplus.gov)
  • What are the treatments for testicular cancer? (medlineplus.gov)
  • Can Testicular Cancer Be Found Early? (medlineplus.gov)
  • What Causes Testicular Cancer? (medlineplus.gov)
  • Germ-cell testicular cancer (GCTC) is a malignant neoplasm derived from the primordial germ cell. (nih.gov)
  • Testicular cancer incidence rate has risen globally over the past several decades, with the average increase in the incidence of testicular cancer in Croatia of 7% per annum from the year 1983 to 2007. (nih.gov)
  • Because of advances in diagnostic procedures, sophisticated radiation techniques and especially the introduction of cisplatin based chemotherapy protocols together with advanced postchemotherapy surgical techniques, curability is expected in about 95% of all patients diagnosed with testicular cancer and over 70% of patients with advanced disease. (nih.gov)
  • 15. HLA antigens in patients with germ cell cancer s of the testis. (nih.gov)
  • Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
  • In addition, we are studying the effects of environmental toxicants and targeted cancer therapies on these cells, which may influence patient fertility. (mdanderson.org)
  • For patient education information, see Men's Health , as well as Testicular Cancer and Testicular Self-Exam . (medscape.com)
  • Patients with a history of cryptorchidism are at a greatly increased risk of testis cancer (by a factor of 10-40 times). (medscape.com)
  • The aim of these guidelines is to present the current evidence for the diagnosis and treatment of patients with cancer of the testis. (uroweb.org)
  • Testicular cancer (TC) represents 5% of urological tumours affecting mostly younger males. (uroweb.org)
  • Medical practitioners inform men at increased risk of testicular cancer of their potential increased risk, along with potential benefits and harms associated with screening. (cancer.org.au)
  • Men with testicular cancer talk to their oncologist about sperm banking before commencing chemotherapy or radiation. (cancer.org.au)
  • Population based screening for testicular cancer is not recommended (and randomised controlled trials are not warranted) given the rareness of the disease, lack of test accuracy, and favourable treatment outcomes (even when diagnosed at a late stage). (cancer.org.au)
  • Testicular cancer is one of the more rare forms of cancer with an estimated incidence of approximately 6.5 in every 100,000 men [1] . (cancer.org.au)
  • In 2010 there were 706 new cases of testicular cancer in Australia [1] . (cancer.org.au)
  • Young men are more commonly affected by testicular cancer, with the average age of diagnosis being around 35 years of age [2] . (cancer.org.au)
  • and seminoma, cancer formed from immature germ cells, generally affecting men 25-49 years of age [3] . (cancer.org.au)
  • The prognosis for men diagnosed with testicular cancer has improved dramatically since the 1970s when chemotherapy was introduced to treat the disease. (cancer.org.au)
  • Five-year relative survival for men diagnosed with testicular cancer is approximately 98% [4] . (cancer.org.au)
  • Testicular cancer represents less than 0.1% of all cancer deaths in Australian men [1] . (cancer.org.au)
  • In 2011, there were 16 testicular cancer deaths in Australia [1] . (cancer.org.au)
  • Testicular cancer commonly presents as a small hard lump, swelling, or change in the consistency of the testicle, or there may be a dull ache in the testicle or lower abdomen. (cancer.org.au)
  • The only established risk factors for testicular cancer are a family history (in father or brother) of the disease, personal history of undescended testicle and previous testicular cancer [5] . (cancer.org.au)
  • Males with these risk factors should be informed by their physicians of their potential increased risk of testicular cancer, along with potential benefits and harms associated with screening. (cancer.org.au)
  • There have been no randomised controlled trials on screening for testicular cancer [6] . (cancer.org.au)
  • Advanced testicular cancer can also be cured with treatment [9][10] . (cancer.org.au)
  • In most men with testicular cancer treatment involves the surgical removal of the affected testicle. (cancer.org.au)
  • Testicular cancer and the removal of one testicle does not alter sexual function or fertility. (cancer.org.au)
  • The multi-institutional meta-analysis was conducted by researchers from The international TEsticular CAncer Consortium (TECAC), led by Katherine L. Nathanson, MD , deputy director of Penn's Abramson Cancer Center and Pearl Basser Professor of BRCA-Related Research in the Perelman School of Medicine at the University of Pennsylvania . (newswise.com)
  • This latest set of genetic locations is adding to our understanding of the inherited drivers of testicular cancer, as we look to improve screening among men who may be at high risk," Nathanson said. (newswise.com)
  • When taken together, the results can explain 44 percent of the father-to-son familial risk for testicular cancer, the authors said. (newswise.com)
  • Ifex (ifosfamide) is a cancer ( antineoplastic ) medication used to treat testicular cancer. (rxlist.com)
  • IFEX is indicated for use in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. (rxlist.com)
  • Apart from these, the economic burden from huge expenses for cancer treatments imposes an extreme social burden on a cancer patient and their family members. (hindawi.com)
  • Life changed drastically on April 12, when MacLagan, age 20, learned he has testicular cancer. (iuhealth.org)
  • Case of the Month' from Memorial Sloan Kettering Cancer Center, New York, NY, USA: managing newly diagnosed metastatic testicular germ cell tumour in a COVID-19-positive patient. (qiagen.com)
  • Genetic Variants Detected Using Cell-Free DNA from Blood and Tumor Samples in Patients with Inflammatory Breast Cancer. (qiagen.com)
  • Monitoring CEA levels may be useful for detecting cancer recurrence after tumor excision if the patient initially had an elevated CEA and for refining estimates of prognosis by stage. (msdmanuals.com)
  • GTN)-a disease spectrum that includes hydatidiform mole, nonmetastatic GTN, and metastatic GTN-and in about two thirds of men with testicular embryonal cancer or choriocarcinoma. (msdmanuals.com)
  • Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer. (lu.se)
  • In the Western world, testicular germ cell cancer (TGCC) is the most common malignancy of young men. (lu.se)
  • Twelve of 29 patients had lymph nodes with metastatic testicular cancer. (wustl.edu)
  • Each year, tens of millions of people are diagnosed with cancer around the world, and more than half of the patients eventually die from it. (health.am)
  • Before 1970, the young man with recurrent testicular cancer following orchiectomy was destined to have rapid progression and death from disseminated disease. (health.am)
  • Consequently, the internist caring for the testicular cancer patient in whom durable remission and long-term survival are anticipated must recognize the impact of the disease and its therapy on fertility, employability, insurability, and delayed morbidity. (health.am)
  • Testicular cancer is infrequent, occurring with an incidence of approximately 2 per 100,000 males. (health.am)
  • However, maldescent of the testis does not seem to be causal in the development of testicular cancer but rather a marker for some genetic or dysgenic event in embryonic or fetal life. (health.am)
  • The opposite normally descended testis develops cancer in about one quarter of cryptorchid testis cancer patients. (health.am)
  • Orchiopexy fails to restore normal cancer risk to the patient with testicular maldescent, but it does allow adequate examination of the testis for development of cancer. (health.am)
  • The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer. (ucla.edu)
  • studies have identified mutations in PRDM14 make men more susceptible to testicular cancer. (ucla.edu)
  • However, it did cause the primordial germ cell-like cells to begin proliferating more than usual and to not differentiate correctly, which could be a step toward cancer. (ucla.edu)
  • A new active pharmaceutical ingredient may help against severe forms of testicular cancer , which only respond inadequately to other therapies. (bionity.com)
  • Testicular cancer is the most common malignant tumor disease in men between 20 and 40 years of age. (bionity.com)
  • The laboratory in Bonn was recently able to show that romidepsin is also very effective at fighting testicular cancer cells. (bionity.com)
  • Unlike JQ1, romidepsin is already approved for the treatment of patients with certain types of cancer. (bionity.com)
  • His practice at the Huntsman Cancer Institute primarily focuses on the multidisciplinary treatment of patients with prostate, bladder, kidney, testicular, adrenal, urethral and penile cancers. (utah.edu)
  • Dr. Sanchez then completed a fellowship in urologic oncology at Memorial Sloan Kettering Cancer Center where he received a Young Investigator Award from the American Society of Urologic Oncology to evaluate the mechanisms underlying the association of sarcopenia (low skeletal muscle mass) and poor oncologic outcomes in patients with clear cell renal cell carcinoma. (utah.edu)
  • Cancer immune evasion contributes to checkpoint immunotherapy failure in many patients with metastatic cancers. (elifesciences.org)
  • This study presents a valuable finding on the association between DUX4 expression with features of immune evasion in human tissue and clinical outcomes in patients with advanced urothelial cancer. (elifesciences.org)
  • However, a majority of advanced cancer patients fail to respond to ICI due to de novo or acquired resistance, the mechanistic bases of which remain incompletely understood. (elifesciences.org)
  • It is fairly rare and only around 2,400 men are diagnosed with testicular cancer each year in the UK. (nhsresearchscotland.org.uk)
  • Patients with GCTs were identified from the Children's Oncology Group (COG) Childhood Cancer Research Network. (kaiserpermanente.org)
  • The Foundation supports medical research and direct patient care programs that ease the financial, social and psychological burdens of families with a diagnosis of cancer or other serious blood disorders. (cancerforward.org)
  • The Cancer Center works to improve the outcome for all patients afflicted with these diseases and to develop and perfect new treatment approaches that are the result of the most extraordinary scientific insights. (cancerforward.org)
  • The Foundation's three goals are to fund Ewing's Sarcoma and childhood cancer research, support patients, family, and staff of pediatric oncology units, and provide funding for higher education scholarships. (cancerforward.org)
  • A second opinion on testicular cancer is therefore highly recommended to ensure the best results. (medconsonline.com)
  • Exact causes of testicular cancer have not been defined, but men with undescended testicles, even after correction in childhood, and men with relatives who were affected (e.g., father or brother) have a definitely higher risk. (medconsonline.com)
  • Depending on the testicular cancer type and stage, other treatment options will include systemic chemotherapy and, in the case of seminomas, radiation. (medconsonline.com)
  • Treatment guideline concordance, initiation, and abandonment in patients with non-metastatic breast cancer from the African Breast Cancer-Disparities in Outcomes (ABC-DO) cohort in sub-Saharan Africa: a prospective cohort study. (who.int)
  • This team specialise in the treatment of germ cell and testicular cancers. (christie.nhs.uk)
  • Malignant testicular neoplasms constitute about 1% of all cancers in males. (ecancer.org)
  • These cancers can be cured in nearly all patients. (cancer.org)
  • Unlike other such cancers, choriocarcinoma metastasizes hematogenously, with the testicular primary tumor often small or even "burned-out. (medscape.com)
  • All testicular cancers can be effectively treated if diagnosed and treated early [8] . (cancer.org.au)
  • Germ cell cancers may express features of only one of these histopathologies or mixtures of two or more. (health.am)
  • Dr. Sanchez specializes in the surgical care of patients with urologic cancers using open, laparoscopic, robotic and endoscopic techniques. (utah.edu)
  • Germ cell tumours (GCTs) account for 98% of all testicular cancers. (nhsresearchscotland.org.uk)
  • Testicular cancers differ in their cell structure. (medconsonline.com)
  • In the case reported here, the patient decided to defer the local treatment of his remaining testis. (medscape.com)
  • In one randomized trial, patients with stage I seminoma underwent orchiectomy and were assigned to adjuvant treatment with a single dose of carboplatin or with irradiation of retroperitoneal lymph nodes. (medscape.com)
  • Patients with relapsed seminoma did better than relapsed non-seminomatous germ cell tumours. (ecancer.org)
  • Previous chemotherapy or radiotherapy, except if patient has pure seminoma relapsing after adjuvant radiotherapy or adjuvant chemotherapy with 1-2 doses of single agent carboplatin or if patient has non-seminoma and poor prognosis by IGCCC criteria in the rare case where low-dose induction chemotherapy is given prior to registration because patient is not fit enough to receive protocol chemotherapy (eg. (uclahealth.org)
  • 12. HLA association of testicular seminoma. (nih.gov)
  • Pure choriocarcinoma of the testis is the exception to most of the rules established for testicular seminoma and all other forms of NSGCTs. (medscape.com)
  • Malignant transformation of germ cells is the result of a multistep process of genetic changes. (medscape.com)
  • The malignant transformation of germ cells is thought to be caused by developmental and hormonal disturbances, probably related to environmental and lifestyle factors because of rapidly increasing incidence of TGCC in some countries. (lu.se)
  • Second-line chemotherapy in testicular germ cell tumours can result in long-term disease control and all patients who are fit to tolerate second-line therapy should be offered it. (ecancer.org)
  • The purpose of this study is to determine whether accelerated BEP chemotherapy is more effective than standard BEP chemotherapy in males with intermediate and poor-risk metastatic germ cell tumours. (uclahealth.org)
  • 18. HLA system and testicular germinative tumours. (nih.gov)
  • This document addresses post-pubertal testicular germ-cell tumours (TGCTs) in the male including spermatocytic tumour and sex cord/gonadal stromal tumours. (uroweb.org)
  • Since 2008, the TC Guidelines contains a separate chapter on testicular stromal tumours. (uroweb.org)
  • Back pain--a presentation of metastatic testicular germ cell tumours. (ox.ac.uk)
  • The aim of the study is to determine if accelerated BEP chemotherapy is superior to standard BEP as a 1st line therapy for patients with intermediate and poor-risk metastatic germ cell tumours. (nhsresearchscotland.org.uk)
  • Paternal Occupational Exposure to Heavy Metals and Welding Fumes and Testicular Germ Cell Tumours in Sons in France. (who.int)
  • [ 15 ] The standard treatment for ITGCN in the contralateral testis after orchiectomy for invasive testicular malignancy is, therefore, radiotherapy to the testis at a dose of 16-20 Gy delivered in 2 Gy fractions. (medscape.com)
  • In a study by Petersen, [ 15 ] all 49 patients who received 16-20 Gy radiation remained tumor-free for more than 5 years, whereas 1 of 14 patients who received a dose of 14 Gy developed invasive testicular malignancy. (medscape.com)
  • No evidence of intratubular germ cell neoplasia unclassified was identified. (scirp.org)
  • All patients with back pain had para-aortic node metastases. (ox.ac.uk)
  • Patients with retroperitoneal metastases were offered two cycles of chemotherapy. (wustl.edu)
  • We report a case of a patient with a non-seminomatous testicular germ cell tumor who presented with bone marrow metastases after intensive chemotherapy. (bvsalud.org)
  • Clark and Gell coaxed human pluripotent stem cells, which can create any cell type in the body, to differentiate into germ cells, at the embryonic stage of germ cell formation, when they are known as primordial germ cells. (ucla.edu)
  • In 112 patients with TGCT, screening for constitutional deletions in the AZF region was performed by multiplex polymerase chain reaction analysis in DNA extracted from peripheral blood lymphocytes. (nih.gov)
  • In the latest study, TECAC researchers analyzed genetic data from 10,156 testicular germ cell tumor cases and 179,683 controls in the largest GWAS of TGCT to date. (newswise.com)
  • Results from our investigation provide further understanding of the genetic architecture of TGCT, enhance comprehension of the biology of male germ cell development, and highlight biological pathways specifically important to TGCT," the authors wrote. (newswise.com)
  • 13. Cultured stem-cells from human testicular teratomas: the nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma. (nih.gov)
  • Then, they engineered the primordial germ cell-like cells to produce more PRDM14. (ucla.edu)
  • They found that higher levels of PRDM14 didn't block the formation of primordial germ cell-like cells. (ucla.edu)
  • Extracranial germ cell development from primordial germ cells. (kaiserpermanente.org)
  • During this stage of germ cell development, aberrant chromatid exchange events associated with crossing over can occur. (medscape.com)
  • If CIS is found after a testicular biopsy (such as for fertility problems), the doctor may recommend that it not be treated right away. (cancer.org)
  • A testicular biopsy was performed and showed the presence of all of germinative components, germ cell sloughing, and mild hypospermatogenesis. (scirp.org)
  • Inguinal orchiectomy, rather than transcrotal biopsy, is the preferred surgical approach for retrieval of diagnostic testicular tissue. (health.am)
  • Time to correct diagnosis from first visit to a doctor was significantly longer in those with back pain than in those with testicular symptoms. (ox.ac.uk)
  • The diagnosis of germ cell tumor of the testis requires histopathologic examination of tissue obtained from an orchiectomy specimen. (health.am)
  • 10. [Differentiation of human germ cell tumor cells]. (nih.gov)
  • Dr. Joanna Gell (left) and Amander Clark examine germ cell tumor cells in the lab at UCLA. (ucla.edu)
  • Reduced fertility is associated with TGCTs and reduced fertility and TGCTs might share genetic risk factors according to the testicular dysgenesis hypothesis. (nih.gov)
  • Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study. (qiagen.com)
  • As a core member of the BMT Clinical Trials Network (BMT CTN), SWOG, and in collaboration with industry sponsors, Moffitt offers an advanced program that hosts a number of transplant and CAR T as well as other cutting-edge cellular immunotherapy clinical trials, offering patients the opportunity to benefit from specialized techniques and technologies that aren't yet available elsewhere. (moffitt.org)
  • A major proportion of patients with these unusual malignancies may expect cure with systemic chemotherapy. (health.am)
  • The main goals of treatment, whether hormonal or surgical, are (1) to allow the testicle to occupy a normal anatomic position, (2) to preserve fertility and hormonal production, and (3) to diagnose potential testicular malignancies. (medscape.com)
  • The role of the Level IV trauma center is to provide resuscitation and stabilization for severely injured adult or pediatric patients before transferring them to a higher level trauma system hospital. (salemhealth.org)
  • This is the guiding principle of the Alliance for Radiation Safety in Pediatric Imaging, a 13-member organization consisting of leading medical societies, agencies, and regulatory groups that have joined forces to impact patient care and change practice through an educational and awareness campaign ( Fig. 1 ). (ajronline.org)
  • Fig. 1 - Sample advertisement used for educational and awareness campaign conducted by Alliance for Radiation Safety in Pediatric Imaging, a 13-member organization consisting of leading medical societies, agencies, and regulatory groups that have joined forces to impact patient care and change practice. (ajronline.org)
  • This message is targeted to the radiologists who perform relatively few CT examinations of pediatric patients in their hospital or outpatient practice but who, in aggregate, perform many pediatric CT examinations throughout the United States. (ajronline.org)
  • We know radiologists and radiology technologists want to do the best for their pediatric patients but may be hampered by a lack of familiarity with pediatric protocols. (ajronline.org)
  • Interhospital Variability in Perioperative Red Blood Cell Ordering Patterns in United States Pediatric Surgical Patients. (seattlechildrens.org)
  • Defining the Need for Transitional Care From Pediatric to Adult Surgery for Young Adult Patients With Surgically Corrected Congenital Anomalies. (seattlechildrens.org)
  • Transitional care in pediatric neurosurgical patients. (seattlechildrens.org)
  • Lymph nodes were negative in 17 of 29 patients. (wustl.edu)
  • Use with caution in patients with severe irritable bladder symptoms. (nih.gov)
  • RESULTS: Symptoms of depression and anxiety, measured by the Hamilton Depression Scale, Beck Depression Inventory, and Beck Anxiety Inventory, were reduced after the intervention in both groups of patients. (bvsalud.org)
  • Sexual transmission of DENV was recently reported in a male patient returning to Spain from Cuba and Puerto Rico who developed dengue symptoms at the time of arrival, 7-10 days after having unprotected sexual intercourse with a male partner, who also developed dengue ( 13 ). (cdc.gov)
  • Although these patients usually present with good prognosis, there are still specific clinical questions where novel biomarkers are needed to complement the ones already used in the clinic. (qxmd.com)
  • It has been reported that an increase in PDE11A expression affects the proliferation of glioblastoma and worsens patient prognosis. (spandidos-publications.com)
  • Is gynecomastia related to the disease characteristics and prognosis in testicular germ cell tumor patients? (dirjournal.org)
  • Since then, testicular maldescent has been the subject of many clinical studies, but its embryology, effects on fertility, and ultimate clinical impact remain topics of discussion and research. (medscape.com)
  • Another theory of testicular maldescent has been based on intrinsic testicular or epididymal abnormalities. (medscape.com)
  • Germ cells are located in the germinal ridge close to the kidney in the retroperitoneum. (medscape.com)
  • Z. Bing, "Obstructive Azoospermia in a Patient with VATER Association," Open Journal of Pathology , Vol. 2 No. 4, 2012, pp. 159-161. (scirp.org)
  • A stroll through the present and future of testicular germ cell tumour biomarkers. (qxmd.com)
  • Although there will be almost complete testosterone deficiency after orchiectomy of a solitary testis, only around 40% of patients who receive radiotherapy can be expected to need testosterone replacement. (medscape.com)
  • In the present case, orchiectomy of the solitary testis rather than radiotherapy was a reasonable option for two reasons: the patient already had androgen insufficiency, and tissue was required for the attempted in vitro sperm extraction. (medscape.com)
  • Ten percent of patients with a GCT have a history of cryptorchidism. (medscape.com)
  • Several potential explanations for the pathophysiology of cryptorchidism have been proposed, including gubernacular abnormalities, reduced intra-abdominal pressures, intrinsic testicular or epididymal abnormalities, and endocrine abnormalities, as well as anatomic anomalies (eg, fibrous bands within the inguinal canal or abnormal arrangement of the cremasteric muscle fibers). (medscape.com)
  • Beyond the statistical significance of the new loci, the study also demonstrated two relevant biological pathways tied to disease susceptibility, male germ cell development and chromosomal segregation during cell division. (newswise.com)
  • Most of the patients (30, 65.2%) presented with lung metastasis and 11 (23.9%) patients with liver metastasis. (ecancer.org)
  • Introduction: Metastasis to the bone marrow is rare in testicular germ cell tumor patients. (bvsalud.org)
  • The current patient underwent testicular ultrasound and measurement of serum tumor marker levels (hCG, AFP, and LDH) every 4 months. (medscape.com)
  • Young men with back pain should be examined for testicular disease and should also be asked about past testicular abnormalities. (ox.ac.uk)
  • Other risk factors include various genitourinary abnormalities such as inguinal hernia, ureteral duplication, abnormal lobulation or orientation of the kidney, and testicular hydroceles. (health.am)
  • 2. Primary human testicular PDGFRα+ cells are multipotent and can be differentiated into cells with Leydig cell characteristics in vitro. (nih.gov)
  • In several studies, three PDE11A mutations have been reported in patients with Cushing syndrome with primary pigmented nodular adrenocortical disease or isolated micronodular adrenocortical disease without other genetic defects. (spandidos-publications.com)
  • The Hofmann Laboratory studies the biology of male germ line stem cells, which are precursors of sperm cells. (mdanderson.org)