AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Diabetes Mellitus, Type 2InsulinInsulin ResistanceReceptor, InsulinGlucoseBlood GlucoseAdipose TissueInsulin Receptor Substrate ProteinsInsulin, Long-ActingHypoglycemic AgentsInsulin AntibodiesInsulin AntagonistsIslets of LangerhansInsulin LisproGlucose Tolerance TestInsulin Infusion SystemsGlucose Clamp TechniqueInsulin AspartInsulin, IsophaneHyperinsulinismInsulin, Regular, PorkInsulin-Secreting CellsInsulinsGlucagonObesityC-PeptideInsulin, Regular, HumanDiabetes Mellitus, Type 1ProinsulinFastingHyperglycemiaMuscle, SkeletalLiverSignal TransductionFatty Acids, NonesterifiedHypoglycemiaGlucose Transporter Type 4Diabetes MellitusAdipocytesDiabetes Mellitus, ExperimentalInsulin, Short-ActingPhosphorylationGlucose IntoleranceHemoglobin A, GlycosylatedBody WeightTriglyceridesInsulin-Like Growth Factor ILeptinDeoxyglucosePhosphoproteinsMonosaccharide Transport ProteinsPhosphatidylinositol 3-KinasesCells, CulturedInsulinomaAdiponectinKineticsPostprandial PeriodTime FactorsBiphasic InsulinsHomeostasisProto-Oncogene Proteins c-aktGlycogenRats, WistarLipidsBody Mass IndexMetforminGlucagon-Like Peptide 1Cell LineDose-Response Relationship, DrugPancreasEatingDietary FatsLipid MetabolismThiazolidinedionesRNA, MessengerMice, ObeseRats, Inbred StrainsRats, Sprague-DawleyBody CompositionInfusions, SubcutaneousRats, ZuckerMuscle ProteinsMice, Inbred C57BLDietary Carbohydrates3T3-L1 CellsLipolysisMyotonic DystrophyStreptozocinReceptor, IGF Type 1Gene Expression RegulationMetabolic Syndrome XReference ValuesTolbutamideDiet, High-FatEnergy MetabolismBiological TransportMice, KnockoutDietAdiposityGlycogen Synthase
ResistanceGlucoseDiabetes mellitusGlycemic controlT1DMHbA1cGlargineObesityMetforminHyperglycemia2023Diabetic patientsOxidativeDefectDiagnosisChildren and adolescentsMethodsTriglyceridesSensitivityPRISMAReceptorClinicalComplicationsIslet cellPancreasEfficacySignificantly2016BaselineTreatmentLevelsPeripheralTherapyBloodObese miceRiskResultsInflammation2022MetabolicallyMortalityChronicFactorsYearsConclusionsAbnormalityMetabolism
Resistance31
Glucose29
  • LPS-mediated TLR4 activation can suppress glucose-induced insulin secretion by β-cells. (wikipedia.org)
  • Objective: In China, a low-fat diet (LFD) is mainly recommended to help improve blood glucose levels in patients with type 2 diabetes mellitus (T2DM). (mdpi.com)
  • Glucagon-like peptide-1 (GLP-1) is an important endogenous incretin hormone, which stimulates glucose-dependent insulin secretion from the pancreatic islet cells and supports glucose homeostasis [ 7 ], as well as stimulating β -cell proliferation and inhibiting β -cell apoptosis, increasing insulin sensitivity, and inhibiting glucagon secretion and gastrointestinal motility [ 7 - 10 ]. (hindawi.com)
  • Our goals today are to talk about cardiovascular disease with respect to insulin, glucose, metabolic syndrome, and diabetes management. (consultantlive.com)
  • Fasting blood glucose ( D ) and insulin ( E ) levels were measured ( n = 7-13), and a GTT ( F ) was performed. (jci.org)
  • No significant changes were observed in fasting plasma glucose, quantitative insulin sensitivity check index, hs-CRP, superoxide dismutase, catalase and uric acid in the RS2 group as compared with the control group. (nih.gov)
  • CAo and CAt combination can be used to significantly improve dry skin condition through increasing SOD activity in T2DM patients with controlled blood glucose. (hindawi.com)
  • The body uses insulin to help bring glucose, also known as blood sugar, from the blood into the cells for energy. (medicalnewstoday.com)
  • These results show plainly the connection between CAD severity and the lipid, glucose, coagulation, and immunologic status of CAD patients, and substantiate the importance of sufficient treatment in this group of patients - in particular, CAD patients suffering from type 2 diabetes mellitus. (dovepress.com)
  • Type 2 diabetes mellitus (T2DM) is a chronic condition characterized by the lack of insulin, which results in high blood glucose levels. (yonsei.ac.kr)
  • Thus, it is traditionally treated by injecting insulin to control glucose levels. (yonsei.ac.kr)
  • Recombinant insulin analogs, insulin pumps, and newer devices for home monitoring have drastically improved the ability to control glucose concentrations in patients with DM. (wikidoc.org)
  • Diabetic patients, especially those on insulin, may not recognize symptoms as DKA because the serum glucose is not elevated. (uspharmacist.com)
  • 5 Low plasma glucose concentrations, in turn, create a carbohydrate deficit and volume depletion, stimulating glucagon secretion and suppressing insulin production. (uspharmacist.com)
  • There are newer electronics with complex algorithms capable of calculating insulin bolus doses necessary to maintain glucose level within a set range as measured by a continuous glucose monitor (CGM). (medscape.com)
  • Ultimately, this technology will likely lead to an "artificial pancreas" that automatically senses glucose level and its rate of change and adjusts insulin dosing accordingly. (medscape.com)
  • The patient tests his or her blood sugar level, and the glucose level is either entered manually or automatically communicated to the pump, depending on the pump model. (medscape.com)
  • Some insulin pumps facilitate direct communication between the patient's glucose meter and insulin pump. (medscape.com)
  • Dr. Laura A. Young and colleagues from the University of North Carolina at Chapel Hill examined the efficacy of self-testing blood glucose levels by people with Type 2 diabetes (T2DM). (acsh.org)
  • People with Type 1 diabetes, who must use insulin, certainly benefit from self-monitoring blood glucose (SMBG- they must know if their insulin levels take blood glucose too low or if more is needed - it can be lifesaving). (acsh.org)
  • These findings and others support the recommendations of the Society of General Internal Medicine and Endocrine Society that discourage frequent blood glucose monitoring among patients with type 2 diabetes. (acsh.org)
  • On an individual level, for patients with T2DM who do not use insulin, these results mean fewer finger sticks and concern about fluctuating blood glucose levels. (acsh.org)
  • Limitations of glycated hemoglobin (HbA1c) per se , underutilization of continuous glucose monitoring (CGM), and lack of an easy to interpret and standardized system for glucose reporting are considered among the key contributors to continued suboptimal glycemic control in diabetes patients despite advances in therapeutics ( 1 ). (frontiersin.org)
  • The main drawbacks of self-monitoring blood glucose (SMBG) systems include inadequate patient compliance to intermittent capillary sampling, unreliability of patient-recorded data, inability to capture and store large amounts of glycemic data including hypoglycemic episodes for extended periods of time ( 2 ). (frontiersin.org)
  • The use of empagliflozin/metformin for managing T2DM in MS improved fasting blood glucose levels and HbA1c, demonstrating the effectiveness of this combination in both ASCVD and CVD risk factors patients. (mims.com)
  • The guidelines recommend insulin treatment in all patients who present with ketosis or extremely high blood glucose levels because it may not be clear initially whether these patients have type 2 or type 1 diabetes. (medscape.com)
  • Fingerstick self-glucose monitoring is recommended for all patients receiving insulin or sulfonylureas, those starting or changing therapy, and those who have not met treatment goals or who have intercurrent illness. (medscape.com)
  • After blood glucose levels are normalized, efforts to taper insulin with progressive substitution of an oral agent are undertaken. (medscape.com)
  • It focuses on patient education, dietary advice, managing cardiovascular risk, managing blood glucose levels, and identifying and managing long-term complications. (bvsalud.org)
Diabetes mellitus32
  • Cardiovascular disease is a major cause of morbidity and mortality in patients with diabetes mellitus (DM). (hindawi.com)
  • Recently more stable GLP-1 analogues, such as exenatide, have been approved for clinical use against type 2 diabetes mellitus (T2DM). (hindawi.com)
  • Type 2 diabetes mellitus (T2DM) is a common complication of obesity. (jci.org)
  • A randomized, controlled, parallel-group clinical trial group of 56 females with type 2 diabetes mellitus (T2DM) was divided to 2 groups. (nih.gov)
  • Pathogenesis of dry skin in type 2 diabetes mellitus (T2DM) rises from the chronic hyperglycemia causing an increase in advanced glycation end-products (AGEs), proinflammatory cytokines, and oxidative stress. (hindawi.com)
  • Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. (academicjournals.org)
  • Diabetes mellitus (DM) is the metabolic homeostasis disorder regulated by insulin which causes abnormalities in the carbohydrate and lipid metabolism. (wikidoc.org)
  • Type 1 diabetes (also called juvenile-onset diabetes mellitus, DM1, T1DM, and insulin-dependent diabetes mellitus) is considered an immuno-mediated disease that results in a gradual destruction of insulin-producing pancreatic beta cells, and subsequently leads to their complete loss and total dependence on exogenous insulin. (wikidoc.org)
  • Type 2 diabetes mellitus (T2DM) is characterized by two underlying defects. (wikidoc.org)
  • Examine the use of insulin, including pharmacokinetic parameters to reach glycemic control in patients with type 2 diabetes mellitus (T2DM). (pharmacytimes.com)
  • Vitamin D deficiency and insufficiency are also more common across type 2 diabetes mellitus (T2DM) patients. (karger.com)
  • As the burden of disease from diabetes rises to epidemic proportions, RGA's Heather Lund asks in On the Risk whether the possibility of remission for Type 2 diabetes mellitus (T2DM) signals an opportunity to escape a major public health traffic jam. (rgare.com)
  • But in recent years, despite initial scanty evidence, there is mounting data that suggests some reversibility in established Type 2 diabetes mellitus (T2DM), particularly in those with short duration. (rgare.com)
  • Objective: The article will review the associations between Prediabetes (PD) and Polycystic Ovarian Syndrome (PCOS) and present factors that decrease the progression of PD into type 2 diabetes mellitus (T2DM).Metformin will also be examined for its role in ovulation induction, pregnancy and ameliorating the metabolic syndrome. (scirp.org)
  • The management of type 1 and type 2 diabetes mellitus (T1DM, T2DM) has evolved with the availability of various antidiabetic agents. (uspharmacist.com)
  • Oxidative stress was found to be associated with type 2 diabetes mellitus (T2DM), which (i) represents another prevalent disease associated with obesity and often aging, and (ii) is considered to be a risk factor for AD development. (nih.gov)
  • Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells, leading to absolute insulin deficiency in patients as well as a requirement for exogenous insulin supplementation for survival [ 6 ]. (karger.com)
  • The aim of this study was to assess the quality of care for type 2 diabetes mellitus (T2DM) patients from these ethnic minority groups compared with the care received by Norwegians. (biomedcentral.com)
  • In the developing world, both urbanisation and a shift towards a westernised lifestyle are risk factors for developing type 2 diabetes mellitus (T2DM). (biomedcentral.com)
  • In Norway, the majority of T2DM patients are cared for in general practice whereas type 1 diabetes mellitus (T1DM) patients usually receive hospital based specialist care. (biomedcentral.com)
  • For those aged 20-39 years, it is reasonable to measure traditional risk factors every 4-6 years to identify major factors (e.g., tobacco, dyslipidemia, family history of premature ASCVD, chronic inflammatory diseases, hypertension, or type 2 diabetes mellitus [T2DM]) that provide rationale for optimizing lifestyle and tracking risk factor progression and need for treatment. (acc.org)
  • Adherence to the mediterranean diet in patients with type 2 diabetes mellitus and HbA1c Level. (nuthealth.org)
  • We analyzed the association between adherence of a MeDiet in patients with type 2 diabetes mellitus (T2DM) and levels of HbA1c. (nuthealth.org)
  • Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid levels status. (heraldopenaccess.us)
  • Dyslipidemia is common in patients with type 2 diabetes mellitus. (heraldopenaccess.us)
  • Type1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM) are the commonest types of DM, this classification is important for both clinically in assessing the need for treatment, and also in understanding the causes of diabetes which are entirely different in the two groups [2]. (heraldopenaccess.us)
  • The TRIGGER apps provides diabetes self-management education, specifically developed for patients with type 2 diabetes mellitus on insulin therapy. (bmj.com)
  • To prospectively assess the long-term safety of statins in patients with prediabetes/type 2 diabetes mellitus (T2DM) and nonalcoholic steatohepatitis (NASH). (medscape.com)
  • Comparative predictiveness of major lipid and lipoprotein parameters for cardiovascular events in patients with type 2 diabetes mellitus (T2DM) who are treated with statins is not well documented. (bvsalud.org)
  • From the abstract: 'The increasing prevalence of type 2 diabetes mellitus (T2DM) and its associated health complications highlight the need to develop predictive models for early diagnosis and intervention. (cdc.gov)
  • Diabetes Mellitus (DM) is a group of metabolic disease characterized by hyperglycemia resulting from defects secretion or insulin action, or both. (bvsalud.org)
  • This systematic review provides a high-quality, comprehensive summary of recommendations on hypertension (HT) and type 2 diabetes mellitus (T2DM), accentuating patient blood pressure, HbA1c levels, patterns of drug treatment, management, and screening of these diseases. (bvsalud.org)
Glycemic control3
  • We designed a study to evaluate the impact of structured SMBG on glycemic control in non-insulin-treated type 2 diabetes (T2DM) patients. (unito.it)
  • BOSTON - With the current demand for type 2 diabetes drugs that both improve glycemic control and help patients shed large amounts of weight, liver specialists have speculated that the metabolic benefits could also extend to the liver. (medscape.com)
  • Although there are disparities in patient portal use, patients use portals to manage their medications, are enthusiastic about further leveraging portals to support medication management and adherence, and those who use a portal more frequently have better glycemic control. (jmir.org)
T1DM7
  • Therefore, T1DM results from an absolute insulin deficiency, and relative deficiency in T2DM. (wikidoc.org)
  • 10 In Europe, dapagliflozin is approved for use in T1DM patients with a BMI of 27 kg/m 2 or higher. (uspharmacist.com)
  • 10 The FDA has yet to approve SGLT2i as an adjunct to insulin in T1DM patients, owing to the increased risk of fatal DKA. (uspharmacist.com)
  • In this CME, Katrina Han, MD, and Hussain Mahmud, MD, discuss how to implement treatment strategies for T2DM by implementing new insulin and non-insulin therapies once available, identify outcomes for patients with or high at-risk of T1DM by implementing preventive therapies, and describe patient safety/monitoring and clinical outcomes with the use of new diabetes technology. (upmcphysicianresources.com)
  • Identify outcomes for patients with or high at-risk of T1DM by implementing preventative therapies. (upmcphysicianresources.com)
  • Upon successful completion of the case, students should understand the basics of metabolic acidosis in T1DM, differences between T1DM and T2DM, and the behavior of the blood buffer equilibrium in response to physiological change. (nsta.org)
  • Distinguish T1DM from T2DM. (nsta.org)
HbA1c3
  • Conclusion: In the present study, RBSO appeared to improve sugar metabolism as evidenced by reduction in FBS, PPBS and HbA1c in type-2 diabetic patients. (longdom.org)
  • Conclusions: Although we found not enough evidence to support that a MeDiet is associated with lower levels of HbA1c in patients with T2DM, our results suggested an inverse trend. (nuthealth.org)
  • Insulin therapy is indicated in symptomatic patients with persistent hyperglycemia, the presence of an HbA1c of more than 9%, or ketoacidosis. (medscape.com)
Glargine2
  • Aim: To examine changes in patient-reported outcome (PRO) measures in patients with type 2 diabetes (T2DM) on oral agents who initiated insulin (insulin lispro mix 25/75 [LM25] or insulin glargine) in the DURABLE trial (n = 580). (rti.org)
  • Weekly Icodec versus Daily Glargine U100 in Type 2 Diabetes without Previous Insulin. (upmcphysicianresources.com)
Obesity3
  • Thus, IgG sialylation and endothelial FcγRIIB may represent promising therapeutic targets to sever the link between obesity and T2DM. (jci.org)
  • It was concluded that IR is strongly associated with obesity and had an important role in the pathogenesis and increased complication of diabetes which could be used as excellent indicators for early-stage DN in T2DM patients and thus decreasing mortality and morbidity. (academicjournals.org)
  • This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Metformin9
  • The use of metformin has shown mixed results in this patient population as a therapy to improve ovulation function and the metabolic syndrome and showed no definitive reduction in the rate of miscarriage. (scirp.org)
  • The role of metformin remains undefined in the infertile PCOS patient. (scirp.org)
  • 1 Biguanides-most notably metformin-have been used in conjunction with sulfonylureas, thiazolidinediones, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors to treat T2DM. (uspharmacist.com)
  • The primary aim of this study is to evaluate the safety and tolerability of AZD1656 in T2DM patients treated with metformin and sulfonylurea. (astrazenecaclinicaltrials.com)
  • Cost-Utility Analysis of Glucagon-Like Peptide-1 Agonists Compared with Dipeptidyl Peptidase-4 Inhibitors or Neutral Protamine Hagedorn Basal Insulin as Add-On to Metformin in Type 2 Diabetes in Sweden. (lu.se)
  • Recognize that, in patients with PCOS who are receiving metformin, possible resumption of normal ovulation and menstrual cycles increases the risk of pregnancy. (medscape.com)
  • If metformin is unsuccessful as monotherapy, the addition of insulin, a sulfonylurea, or another hypoglycemic agent may be appropriate. (medscape.com)
  • Of 646 individuals in the cross-sectional analysis, a majority in each period received metformin (64.9% vs 70.4%) and/or insulin (38.1% vs 38.4%), while fewer used sulfonylureas (5.6% vs 3.6%) with non-significant changes over time. (cdc.gov)
  • Youth-onset T2D is still largely being treated with metformin and/or insulin. (cdc.gov)
Hyperglycemia2
  • thereby achieving the full metabolic normalization not yet possible and making some degree of hyperglycemia persists in virtually all patients with diabetes. (wikidoc.org)
  • It is defined as group of metabolic disorder that is characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both, which leads to alteration in carbohydrate, fat and protein metabolism [1]. (heraldopenaccess.us)
20231
  • Maintenance of body weight and T2DM after normalization of ALT was also very important," they write in a scientific poster presented here at The Liver Meeting 2023: American Association for the Study of Liver Diseases (AASLD). (medscape.com)
Diabetic patients6
  • The diabetic patients' genome sequences differ from the controls' genome in specific loci along and around numerous genes, and these differences in the nucleotide sequences alter phenotypic traits that exhibit increased susceptibility to the diabetes. (wikipedia.org)
  • The mutated genotypes of GT eNOS gene was significantly more frequent in diabetic patients. (scirp.org)
  • This case―control study was conducted on 200 subjects divided in two groups, the first group is composed of 100 diabetic patients hospitalized in Endocrinology and Diabetology department of Military Hospital of Tunis in period between February and October 2017. (scirp.org)
  • There was reduction in FBS and PPBS across all RBSO groups, but was significant only in the diabetic patients (p=0.010). (longdom.org)
  • Abstract Background Depression is more common in diabetic patients, with a 1.5-fold increased risk of death.Melissa officinalis (M. officinalis) have anti-diabetic and anti-depression activities. (researchgate.net)
  • The prevalence of dyslipidemia in type 2 diabetic patients was 85%, prevalence of dyslipidemia in males was 86% while in females was 84% but the difference was not significant (P-value 0.4). (heraldopenaccess.us)
Oxidative4
  • Supplementation with RS2 may be improved glycemic status, endotoxemia and markers of oxidative stress in patients with T2DM. (nih.gov)
  • Concentration of AGEs in diabetes patients is significantly higher due to the hyperglycemic state and oxidative stress. (hindawi.com)
  • Several pathological features of T2DM and AD may contribute to the development of hippocampal IR, including increases in oxidative stress and in the amount of pro-inflammatory cytokines and amyloid-β peptides, as well as hypothalamic-pituitary-adrenal axis dysfunction. (nature.com)
  • This study aimed to determine the effects of hesperidin supplementation on inflammation, oxidative stress, and lipid profile in depressed coronary artery bypass graft surgery (CABG) patients. (researchgate.net)
Defect1
  • Thereafter, T2DM develops due to a defect in insulin secretion that prevents such secretion from matching the increased requirements imposed by an initial insulin-resistant state. (wikidoc.org)
Diagnosis5
  • In fact, dapagliflozin is the only member of this class that has been approved for heart failure treatment regardless of a T2DM diagnosis. (uspharmacist.com)
  • Mean age at the time of diagnosis of T2DM was 8-15 years younger in minority groups compared with Norwegians. (biomedcentral.com)
  • The diagnosis of liver disease in COVID-19 patients can be challenging for the clinician. (randox.com)
  • The study showed that, in fact, the projective third of additional diagnosis can cinnamon lower your A1C and patients with type 1 diabetes are overweight. (atime.org)
  • Patients who are not ill at diagnosis can be treated initially with lifestyle changes (eg, diet, exercise, weight control). (medscape.com)
Children and adolescents1
  • However, because few patients can maintain euglycemia with lifestyle changes alone, most children and adolescents require medication. (medscape.com)
Methods6
  • Methods: Subjects completed generic and diabetes-specific health-related quality-of-life measures (RAND-36 and Diabetes-39) and a symptom assessment measure (DSC-Revised) at baseline and 6 months post insulin initiation. (rti.org)
  • Methods: We conducted a prospective case-control study in which we inclu ded 200 subjects divided into 100 patients with type 2 diabetes and 100 controls in apparent good health. (scirp.org)
  • Patients and Methods: This was a cross-sectional study in individuals with T2DM participating in the PREDIMED trial at the centre of Pamplona. (nuthealth.org)
  • Methods The present case-control study carried out on 85 patients who. (researchgate.net)
  • Methods: From the Korean Nationwide Cohort, 11,900 patients with T2DM (≥40 years of age) without a history of cardiovascular disease and receiving moderate- or high-intensity statins were included. (bvsalud.org)
  • Patients and Methods. (bvsalud.org)
Triglycerides1
  • rs7873784 was also associated with the abnormal metabolic phenotype accompanying T2DM (levels of fasting insulin and triglycerides, abnormal low-density lipoprotein and high-density lipoprotein cholesterol levels). (wikipedia.org)
Sensitivity2
  • In HFD-fed mice, supplementation with the sialic acid precursor N-acetyl-D-mannosamine restored IgG sialylation and preserved insulin sensitivity without affecting weight gain. (jci.org)
  • In T2DM, peripheral tissue insulin sensitivity and β -cell pancreas insulin secretion are disrupted. (hindawi.com)
PRISMA3
  • Prospective, randomized trial on intensive SMBG management added value in non-insulin-treated T2DM patients (PRISMA): a study to determine the effect of a structured SMBG intervention. (unito.it)
  • The Prospective, Randomized Trial on Intensive SMBG Management Added Value in Non-insulin-Treated T2DM Patients (PRISMA) is a 12-month, prospective, multicenter, open, parallel group, randomized, and controlled trial to evaluate the added value of an intensive, structured SMBG regimen in T2DM patients treated with oral agents and/or diet. (unito.it)
  • This scoping review maps out the existing literature on AI-based models for T2DM prediction, adhering to the PRISMA extension for Scoping Reviews guidelines. (cdc.gov)
Receptor1
Clinical6
  • One thousand patients (500 per arm) will be enrolled at 39 clinical sites in Italy. (unito.it)
  • Since the late 1960s, the severity of coronary stenosis was suspected to be a prognostic factor for patients with coronary artery disease (CAD), 1 - 3 and this hypothesis was proven in several clinical studies with long follow-up periods. (dovepress.com)
  • However, it may remain underutilized in clinical practice due to concerns regarding the complexity and inconvenience of CGM use among physicians and patients and also the clinician's reluctance due to lack of experience in interpreting CGM data. (frontiersin.org)
  • Describe patient safety/monitoring and clinical outcomes with the use of new diabetes technology. (upmcphysicianresources.com)
  • This study aimed to evaluate the clinical efficacy of probiotic and prebiotic supplementation on the metabolic parameters, liver enzymes, and inflammation in patients with nonalcoholic fatty liver disease (NAFLD). (researchgate.net)
  • [ 10 ] This perception has had serious clinical implications because many patients with NAFLD are denied statins and other lipid-lowering therapies on a daily basis. (medscape.com)
Complications1
  • Dry skin treated properly in early stages can lower diabetes patients' morbidities and prevent complications, which includes infection, ulcer, and gangrene, which could result in amputation [ 4 ]. (hindawi.com)
Islet cell1
  • Dr Ralph DeFronzo, who is 1 of the greats in endocrinology and diabetes, always pointed out that when you have prediabetes, that is actually a misnomer because you've already lost about 50% of your islet cell insulin-secreting capacity. (consultantlive.com)
Pancreas1
Efficacy4
  • A three-arm prospective, double-blind, randomized, controlled study was performed to evaluate the efficacy of the oral and topical CA extract in 159 T2DM patients with dry skin. (hindawi.com)
  • Efficacy and safety of oral orforglipron in patients with type 2 diabetes: a multicentre, randomised, dose-response, phase 2 study. (upmcphysicianresources.com)
  • During the efficacy of the technologies, the correlation diabetes health tips between T2DM patients with type 2 diabetes. (atime.org)
  • The study aimed to determine the efficacy of M. officinalis extract on depression, anxiety, and sleep quality in patients with type 2 diabetes with depres. (researchgate.net)
Significantly4
  • 0.001) were significantly higher in RA patients than in controls. (researchgate.net)
  • PCOS patients are significantly predisposed to PD and T2DM. (scirp.org)
  • Animal experiments revealed that STZ treatment rendered female rats more susceptible to induction of diabetes than their male littermates with significantly lower plasma insulin levels due to hormonal regulation. (karger.com)
  • [ 12 ] The use of statins was also significantly low (45%) in a cohort of 346 patients with T2DM and NAFLD. (medscape.com)
20162
  • Despite earlier evidence suggesting remission is possible, it is only as recent as 2016 that reference to T2DM reversal was added to the World Health Organization (WHO) Global Report on Diabetes. (rgare.com)
  • The average number of patients per GP practice increased to 9.4 thousand in January 2022, up from 7.7 thousand in 2016 2 . (politicshome.com)
Baseline2
  • We performed multiple imputation and regression models adjusted for baseline value, age, sex, diabetes duration and insulin dose. (bmj.com)
  • liver magnetic resonance spectroscopy and euglycemic insulin clamp (baseline and month 18). (medscape.com)
Treatment13
  • Although skin problems are often found in T2DM patients, the awareness and choice of treatment are commonly lacking. (hindawi.com)
  • In this light, liraglutide, an analog of the human glucagon-like peptide-1 hormone that promotes insulin secretion, is a promising treatment alternative. (yonsei.ac.kr)
  • Therefore, EMN patches can potentially replace injections for liraglutide administration in T2DM treatment. (yonsei.ac.kr)
  • This research is a significant step towards making dissolving microneedles an economical, safe, and clinically viable option for the state-of-the-art treatment of patients, elevating their quality of life. (yonsei.ac.kr)
  • Conclusions: The prevalence of sarcopenia in older adults with T2D on insulin treatment was lower than general population, which may be explained by the insulin anabolic effects. (diabetesjournals.org)
  • Ohki and colleagues evaluated the effectiveness of SGLT-2 inhibitors and GLP-1 agonists as treatment of MAFLD for patients with T2DM. (medscape.com)
  • A total of 54 patients had a 3% or greater reduction in body weight within 8 weeks of beginning treatment with their respective drugs. (medscape.com)
  • Only one in four of most patient groups achieved all four treatment targets and prescribing habits may be sub-optimal. (biomedcentral.com)
  • Implement treatment strategies for T2DM by implementing new insulin and non-insulin therapies once available. (upmcphysicianresources.com)
  • Whether a new patient is being evaluated or an established patient is being followed-up, the multidisciplinary healthcare team should be familiar with recognized treatment guidelines and recommendations for ensuring good diabetes care. (primeinc.org)
  • The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) have recently issued an updated joint position statement, incorporating the recent evolving developments in diabetes care and emphasizing a patient-specific treatment approach for patients with T2DM. (primeinc.org)
  • Multivariate analysis additionally adjusted for physical activity, smoking, time of evolution of the T2DM, body mass index and insulin treatment found similar findings (OR = 0.69, 95% CI 0.17-2.83). (nuthealth.org)
  • Unless an acute complication (eg, recurrent hypoglycemia, persistent ketosis, hyperglycemic hyperosmolar state) occurs or there is poor patient compliance with treatment, type 2 diabetes is usually managed in an outpatient setting. (medscape.com)
Levels5
  • The idea is to limit carbohydrate-rich foods that could raise a person's insulin levels . (medicalnewstoday.com)
  • The physician prescribes bolus insulin based on the carbohydrate content of a meal and for the correction of any elevation of blood sugar levels. (medscape.com)
  • About half of the studied T2DM patients have high serum cholesterol level (52.5%), while 22.5% had low serum HDL- C levels and 39.2% had high serum triglyceride level, most of patients had serum LDL-C levels above normal range (67.5%), so the common patterns of dyslipidemia in this study were LDL-C followed by cholesterol. (heraldopenaccess.us)
  • The risk of MACE was estimated according to on-statin levels of low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), highdensity lipoprotein cholesterol (HDL-C), and non-HDL-C. Results: MACE occurred in 712 patients during a median follow-up period of 37.9 months (interquartile range, 21.7 to 54.9). (bvsalud.org)
  • Conclusion: On-statin LDL-C and non-HDL-C levels are better predictors of the first cardiovascular event than TG or HDL-C in patients with T2DM. (bvsalud.org)
Peripheral1
  • Importantly, both lifestyle (diet and exercise) and pharmacological interventions that are known to alleviate peripheral IR effectively restore hippocampal neuroplasticity in rodent models of T2DM and AD, and this effect may be due to restoration of insulin signalling in the hippocampus. (nature.com)
Therapy7
  • Following experimentation on dogs, their life-saving infusion of a bovine extract of insulin developed by their biochemist colleague, Collip to a 14-year-old boy, Leonard Thompson, in 1922 at the Toronto General Hospital emerged as a sensation in the world of diabetic therapy. (wikidoc.org)
  • Identify potential patient barriers and recommended solutions to initiating insulin therapy to optimize A1C goals. (pharmacytimes.com)
  • 1 Approximately half of T2DM patients will require insulin therapy within 10 years of their diagnoses. (rgare.com)
  • [ 1 ] insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), has been used for more than 30 years. (medscape.com)
  • The chief benefit of insulin pump therapy is customized flexible basal and bolus dosing to meet patients' individual requirements. (medscape.com)
  • Objective To investigate the effect of diabetes self-management education and support via a smartphone app in individuals with type 2 diabetes on insulin therapy. (bmj.com)
  • Statin therapy is safe in patients with prediabetes/T2DM and NASH. (medscape.com)
Blood5
  • If you're insulin resistant, the blood sugar might go up an iota. (consultantlive.com)
  • That's because the best form of diabetes is blood sugar is too high what to do a disease, the body will produce enough insulin to secrete and insulin. (atime.org)
  • They may be achieved that achieved of those with type 2 diabetes are obese, alternative, and the body blood sugar is too high what to do releases insulin. (atime.org)
  • These symptoms are found to cause, is blood sugar too high what can I do the body requires more insulin, it's not enough to produce enough insulin to use insulin. (atime.org)
  • A well structured questionnaire and blood investigation for lipid profile and blood sugar were the tools of data collection from 120 randomly selected T2DM patients registered in the ACC. (heraldopenaccess.us)
Obese mice1
  • Mechanistically, the activation of FcγRIIB by IgG from obese mice impaired endothelial cell insulin transcytosis in culture and in vivo. (jci.org)
Risk13
  • To locate genes and loci that are responsible for the risk of type 2 diabetes, genome wide association studies (GWAS) was utilized to compare the genomes of diabetic patient group and the non-diabetic control group. (wikipedia.org)
  • Explore the role of new long-acting basal insulins in patients with T2DM and evaluate risk of hypoglycemia associated with each. (pharmacytimes.com)
  • Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. (scirp.org)
  • Diabetes constitutes one of the major independent cardiovascular risk factors, and patients with this disease suffer from premature cardiovascular morbidity and mortality. (scirp.org)
  • The main objective of the study was to determine the G894T SNP in the eNOS gene such as risk factor for T2DM in Tunisian population. (scirp.org)
  • The guideline emphasizes patient-physician shared decisions with a multidisciplinary team-based approach to the implementation of recommended preventive strategies with sensitivities to the social determinants of health that may include specific barriers to care, limited health literacy, financial distress, cultural influences, education level, and other socioeconomic risk factors related to short- and long-term health goals. (acc.org)
  • The current state of primary healthcare is ill-equipped to handle the increase of non-communicable diseases (NCDs), with the shortage of GPs and the 9-minute consultation model putting patients at risk. (politicshome.com)
  • Patients with nonalcoholic fatty liver disease have a high cardiovascular risk, but statins are rarely prescribed because of fear of hepatotoxicity. (medscape.com)
  • Only 37% of patients were receiving statins at enrollment despite their high cardiovascular risk. (medscape.com)
  • Patients with NAFLD are at increased risk of cardiovascular disease. (medscape.com)
  • There is a belief among clinicians that patients with NASH are at a higher risk for hepatotoxicity when prescribed a statin, [ 9 ] and it has even been postulated that statins could increase hepatic fat accumulation in patients with NAFLD. (medscape.com)
  • The predictive ability of on-statin LDL-C and non-HDL-C for MACE was prominent in patients at high cardiovascular risk or those with LDL-C ≥70 mg/dL. (bvsalud.org)
  • While many artificial intelligence (AI) models for T2DM risk prediction have emerged, a comprehensive review of their advancements and challenges is currently lacking. (cdc.gov)
Results2
  • Of course, the use of SMBG must be tailored to the situation of each patient, but these results suggest that SMBG is not necesssarily useful for all. (acsh.org)
  • Results: We studied 383 participants with T2DM, 53.4% women (mean age 69 ± 6 years). (nuthealth.org)
Inflammation1
  • Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
20221
  • Méthodes : Nous avons mené une étude rétrospective et descriptive multicentrique d'une durée de 7 mois, du 01er septembre 2021 au 31 mars 2022, portant sur les patients admis dans les unités de réanimation des hôpitaux d'instruction des armées de Libreville (HIAOBO) et d'Akanda (HIAA), pour COVID-19 documentée ou suspectée. (bvsalud.org)
Metabolically1
  • Vitamin D has to be metabolically activated in the kidney, and patients with CKD including diabetic kidney disease (DKD) are not able to produce enough of the active form of vitamin D (1,25(OH) 2 D). Vice versa, the kidneys are assumed to be a classical 1,25(OH) 2 D target. (karger.com)
Mortality2
  • IntroductionRheumatic diseases are autoimmune, inflammatory diseases often associated with cardiovascular (CV) disease, a major cause of mortality in these patients. (researchgate.net)
  • This has a significant number of mortality in patients with type 2 diabetes. (atime.org)
Chronic2
  • Such is the escalation of chronic diet and lifestyle-induced disorders, patients cannot necessarily be diagnosed with one singular condition. (politicshome.com)
  • Helen Stokes-Lampard, chair of the Royal College of General Practitioners, was quoted back in 2017 as saying "Increasingly, patients are living with multiple, long-term chronic conditions, both physical and psychological - and at the same time GPs are being asked to do more checks, ask more questions and give more advice as standard during consultations. (politicshome.com)
Factors2
  • 5,6 Pharmacists should be well versed in EDKA and its precipitating factors in order to educate patients and clinicians on the signs and management of EDKA in patients taking SGLT2i. (uspharmacist.com)
  • 1 In the presence of a carbohydrate deficit due to precipitating factors, there is a reduction in serum insulin and an excess of glucagon, epinephrine, and cortisol. (uspharmacist.com)
Years2
  • Robert Busch, MD: Years before the diabetes starts, the patient is insulin resistant. (consultantlive.com)
  • however, most patients will be diagnosed before the age of 30 years. (wikidoc.org)
Conclusions1
  • Conclusions: Our findings suggest that insulin initiation improves selective PRO in patients with poorly controlled T2DM. (rti.org)
Abnormality1
  • Elevations of aminotransferase is the most common abnormality in patients presenting with COVID-19. (randox.com)
Metabolism1