Patients with resistant. Medical search. Frequent questions

However, few studies have compared the diagnostic efficiency between 68 Ga-PSMA and 18 F-FDG PET/CT and evaluated whether a heterogeneous metabolic phenotype (especially 68 Ga-PSMA-negative [−], 18 F-FDG-positive [+] lesions) exists in patients with castration-resistant prostate cancer (CRPC). (snmjournals.org)
Despite inhibition of serum androgens, many patients develop castration-resistant prostate cancer (CRPC) and the tumor continues to grow, requiring multidrug therapy. (snmjournals.org)
In study B, 23 patients with castration-resistant prostate cancer received probes for CYP3A4 (midazolam), CYP2C9 (warfarin), CYP2C19 (omeprazole), and CYP2C8 (pioglitazone), and transporter substrates for P-glycoprotein (P-gp) (fexofenadine) and breast cancer resistance protein (BCRP)/organic anion transporting polypeptide (OATP) 1B1 (rosuvastatin) at baseline and after repeat once-daily administration of apalutamide 240 mg to steady state. (springer.com)
An open-label, multicenter, phase Ib study investigating the effect of apalutamide on ventricular repolarization in men with castration-resistant prostate cancer. (springer.com)
Efficacy and safety of abiraterone acetate in elderly (75 years or older) chemotherapy naïve patients with metastatic castration resistant prostate cancer. (springer.com)
Potential drug-drug interactions with abiraterone in metastatic castration-resistant prostate cancer patients: a prevalence study in France. (springer.com)
New nomograms can predict survival outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with lutetium-177 prostate-specific membrane antigen ( 177- Lu-PSMA), according to a study published in The Lancet Oncology . (renalandurologynews.com)
PURPOSE: To review the current literature and discuss potential future roles of the novel positron emission tomography (PET) tracers targeting the prostate-specific membrane antigen (PSMA) in patients with castration-resistant prostate cancer (CRPC). (uzh.ch)
First-line options for treating metastatic castration-resistant prostate cancer (mCRPC) were debated throughout the annual meeting of the American Urological Association (AUA). (medpagetoday.com)

On September 17, 2021, an Idaho hospital (hospital A) Treatment of carbapenemase-producing carbapenem-resis- collected sputum by endotracheal tube aspiration of a woman tant Pseudomonas aeruginosa (CP-CRPA) infections is chal- aged 50-65 years (patient 1), who received mechanical ven- lenging because of antibiotic resistance. (cdc.gov)
CP-CRPA infections tilation during 3 of 5 weeks of hospitalization in an intensive are highly transmissible in health care settings because they care unit (ICU) room (room X). Carbapenemase-producing can spread from person to person and from environmental carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) was sources such as sink drains and toilets. (cdc.gov)
Complicated infections from multidrug-resistant Gram-negative bacteria (MDR-GNB) represent a serious problem presenting many challenges. (mdpi.com)
However, providers should be vigilant for the possibility of resistant infections in patients. (calhospital.org)
Data from a prospective, randomized, open-label, active-controlled, multicenter, Phase 4 study comparing oral or intravenous linezolid with intravenous vancomycin for treatment of complicated skin and soft-tissue infections caused by methicillin resistant Staphylococcus aureus was used to determine the association between staphylococcal cassette chromosome mec (SCC mec ) type and patient's clinical presentation, infection severity, intravenous therapy duration and length of stay (LOS). (scirp.org)
Huang, D.B., Reisman, A. and Hogan, P. (2010) Clinical Outcomes by Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type: Isolates Recovered from a Phase IV Clinical Trial of Linezolid and Vancomycin for Complicated Skin and Skin Structure Infections. (scirp.org)
Diep, B.A., Sensabaugh, G.F., Somboonna, N., Carleton, H.A. and Perdreau-Remington, F. (2004) Widespread Skin and Soft-Tissue Infections Due to Two Methicillin-Resistant Staphylococcus aureus Strains Harboring the Genes for Panton-Valentine Leucocidin. (scirp.org)
Herpes simplex virus (HSV) infections are usually chronically recurrent in the normal population and represent a significant cause of morbidity in immunocompromised patients. (unboundmedicine.com)
Results from studies on Multidrug Resistant Tuberculosis prevalence carried out in 2008 in two pilot regions of Tajikistan revealed that multidrug resistance concerned 16% of new infections and 60% of prior infections. (fondation-merieux.org)
We examined the clinical data from patients with CPE infections and their outcomes, concentrating on Klebsiella pneumoniae isolates. (biomedcentral.com)
The clinical characteristics of 33 hospitalised patients with confirmed CPE, including patient-related factors associated with the development of CPE infections, were examined. (biomedcentral.com)
Among the CPE-infected patients ( n = 18) and CPE-colonised patients who developed CPE infections during the study ( n = 3), all but one received standard colistin-based combination therapy. (biomedcentral.com)
This type of multi-layered analysis can be further exploited in Thailand and elsewhere to modify the regimes used for empirical antibiotic treatment and improve the management strategies for CPE infections in hospitalised patients. (biomedcentral.com)
The mrc-1 gene is especially dreaded because it makes bacteria resistant to colistin, the antibiotic of last resort for such infections. (seeker.com)
Colonization with multidrug-resistant (MDR) bacteria is a major risk factor for developing subsequent MDR infections. (biomedcentral.com)
Based on the data from a recent surveillance study performed in a medical ICU in Korea, active surveillance detected carbapenem-resistant- Acinetobacter baumannii (CR-AB) in 15.0% of patients, and approximately one-third of them later developed CR-AB infections [ 14 ]. (biomedcentral.com)
We are working to better understand what microbes and their surrounding environments can teach us about preventing infections, including antimicrobial-resistant infections . (cdc.gov)
However, more research is needed in the field of microbial ecology to expand upon and develop new therapeutic strategies that address colonization, healthcare-associated infections (HAIs), and antimicrobial resistance, all while considering patient safety and the implications for a patient's microbiome. (cdc.gov)
As the second wave washes over India and severely ill patients clog the ICUs, doctors are seeing an uptick in a host of dangerous fungal infections.First, there was an outbreak of mucormycosis or the black-fungus , a rare but dangerous infection, which affects the nose, eye and sometimes the brain. (theunn.com)
Now doctors are reporting a rise in other deadly fungal infections in Covid-19 patients, mostly after a week or 10 days of stay in the ICU.There are two species of Candida fungi - auris and albicans - and they can be fatal for human beings. (theunn.com)
Overuse of steroids and other drugs, which weaken the body's immune system, and underlying conditions make Covid-19 patients in critical care more prone to such infections. (theunn.com)
They are also known as opportunistic infections," says Dr Zachary Rubin, an immunologist.Dr Rubin says patients with HIV/Aids have a significantly increased risk of getting sick with such fungi. (theunn.com)
They bring their infections to the U.S. Multidrug resistant TB can be spread from a person with the TB to a person who has never been infected before. (medleague.com)
Epidemiology and clinical characteristics of patients with carbapenem-resistant enterobacterales infections: experience from a large tertiary care center in a developing country. (bvsalud.org)
Carbapenem -resistant Enterobacterales (CREs) are a significant source of healthcare -associated infections . (bvsalud.org)
For many years before the development of effective antiretroviral therapy (ART), these infections inflicted significant morbidity and mortality on patients living with AIDS. (medscape.com)
Prevention of opportunistic infections (OI) in patients with HIV has since significantly reduced morbidity and mortality in these patients. (medscape.com)
[ 2 ] Patients should be aware of their CD4 count and their risk for specific infections and should begin ART. (medscape.com)
Therefore, since it is a global public health problem involving several sectors, it also requires a global solution in the context of the One Health approach to achieve adequate control through the prevention, reduction, and mitigation of drug-resistant infections. (who.int)

As MDR-TB strains are often resistant to one or more second-line anti-TB drugs, in-depth genotypic and phenotypic drug susceptibility testing is needed to construct personalised treatment regimens to improve treatment outcomes. (ingentaconnect.com)
The RFLP patterns of the isolates from six of these patients remained essentially unchanged (two strains showed one additional band) despite the development of drug resistance. (nih.gov)
The emergence of ACV-resistant strains has been frequently reported as a result of long-term ACV therapy. (unboundmedicine.com)
however, in patients with AIDS, the prevalence of ACV-resistant strains is remarkable (P = 0.001). (unboundmedicine.com)
Alternative antiherpetic agents should be employed to control and reduce the emergence of ACV-resistant strains in patients with AIDS. (unboundmedicine.com)
Some strains of organisms are resistant to nearly every antibiotic. (medleague.com)
Drug-resistant strains have developed because TB treatments have either been improper or the infected patient has not followed instructions for taking the antibiotics. (medleague.com)
Emergence of tance of L. donovani to this drug in the sodium stibogluconate-resistant strains of country. (who.int)
Pseudomonas strains were never resistant to wide spectrum antibiotics. (who.int)

Health Laboratory (UPHL), and CDC was undertaken to No patients were placed in room X after the second clinical identify the etiology of the infection. (cdc.gov)
Exogenous reinfection with multidrug-resistant M. tuberculosis can occur either during therapy for the original infection or after therapy has been completed. (nih.gov)
The international, prospective, and multicenter cohort study also pointed out that people who had surgery in these countries have an increased chance of developing an infection linked to drug-resistant bacteria . (naturalnews.com)
The study enrolled 35 patients with controlled HIV infection (mean baseline HIV RNA serum level of 2.88 log(10) copies/mL by Roche Amplicor Monitor PCR) who were receiving lamivudine 150 mg twice daily as part of their combination anti-HIV treatment regimen for a median of 42.3 months prior to enrollment. (gilead.com)
Wang, J.L., Wang, J.T., Chen, S.Y., Chen, Y.C. and Chang, S.C. (2010) Distribution of Staphylococcal Cassette Chromosome mec Types and Correlation with Comorbidity and Infection Type in Patients with MRSA Bacteremia. (scirp.org)
The most common uropathogen in patients with uncomplicated (uUTI) and complicated (cUTI) urinary tract infection was E. coli 105 (69%) and 76 (70%), respectively. (ku.dk)
The first US case of human infection with the gene-carrying E. coli bacteria occurred in May, in a 49-year-old patient hospitalized in Pennsylvania with a urinary tract infection. (seeker.com)
People who work in hospitals or health-care settings where TB patients are likely to be seen should consult infection control or occupational health experts. (cdc.gov)
This can lead to infection, including a resistant infection. (cdc.gov)
We are seeing an increased number of patients with the infection during the second wave of Covid-19. (theunn.com)
TB enters a healthcare facility in an infected patient whose infection is not recognized or effectively treated. (medleague.com)
The target population was all patients with CRE infection or colonization in the hospital setting. (bvsalud.org)
Immunosuppression resulting from HIV places a patient at risk for infection from organisms that are otherwise relatively mildly hazardous and that would normally be cleared by a competent immune system. (medscape.com)
[ 3 ] As observed in patients with hemophilia who experienced presumed transfusion-related transmission during the 1980s to 1990s, OI generally developed an average of 7 to 10 years after initial HIV infection. (medscape.com)
Resolution WHA46.36 subsequently urged Member States to act rapidly to control tuberculosis through introduction of the strategy of directly observed treatment, short course (DOTS).2 DOTS not only drastically reduces deaths by increasing the cure rate of treatment, but also cuts the transmission of infection and prevents the development of multidrug-resistant tuberculosis. (who.int)

Bergqvist J, Iderberg H, Mesterton J, Bengtsson N, Wettermark B, Henriksson R. Healthcare resource use, comorbidity, treatment and clinical outcomes for patients with primary intracranial tumors: a Swedish population-based register study. (janusinfo.se)

In the United States there have been recent outbreaks of multidrug-resistant tuberculosis. (nih.gov)
16 DECEMBER 2019, BEERSE, BELGIUM - Johnson & Johnson recognizes the World Health Organization (WHO)'s Rapid Communication indicating that all-oral regimens containing Johnson & Johnson's SIRTURO® (bedaquiline) are the preferred treatment options for all patients with multidrug-resistant tuberculosis (MDR-TB) and rifampicin-resistant TB (RR-TB). (jnj.com)
To date, Johnson & Johnson has provided more than 184,000 courses of bedaquiline to 138 countries, including the 30 countries with the highest burden of multidrug-resistant TB (MDR-TB). (jnj.com)
This study aimed to describe the clinical, microbiological, molecular epidemiology and treatment of multidrug resistant tuberculosis (MDRTB) cases in the UK and to determine factors associated with survival. (bmj.com)
A phase III trial of the first-ever biologic medication directed against the human immunodeficiency virus (HIV) has demonstrated the safety and effectiveness of the ibalizumab monoclonal antibody in treating previously treated patients who are infected with multidrug resistant HIV-1. (contagionlive.com)
Background Although new molecular diagnostic tests such as GenoType MTBDRplus and Xpert® MTB/RIF have reduced multidrug-resistant tuberculosis (MDR-TB) treatment initiation times, patients' experiences of diagnosis and treatment initiation are not known. (sun.ac.za)
TB cases are on the increase, and the most serious aspect of the problem is the recent occurrence of outbreaks of multidrug-resistant (MDR) TB, which pose an urgent public health problem and require rapid intervention. (cdc.gov)
Multidrug-resistant TB (MDR TB) is caused by TB bacteria that are resistant to at least isoniazid and rifampin, the two most potent TB drugs. (cdc.gov)
Multidrug-resistant TB (MDR TB) is resistant to more than one anti-TB drug and at least isoniazid (INH) and rifampin (RIF). (cdc.gov)
When a healthcare facility identifies certain multidrug-resistant pathogens within their facility, CDC recommends colonization screening-using laboratory test to identify patients who are colonized. (cdc.gov)
Food borne illnesses caused by shigella, salmonella, and campylobacter have become multidrug resistant. (medleague.com)
Streptococcus pneumonia , a leading cause of pneumonia, has become multidrug resistant. (medleague.com)
According to the World Health Organization, an estimated 9.7% of multidrug-resistant TB (MDR-TB) cases are defined as XDR-TB globally. (who.int)
1,3,4 Globally, the proportion of cases with multidrug-resistant TB (MDR-TB) 4 is 3.3% among new TB cases and 20% among previously treated TB cases, accounting for about 480 000 people in 2014. (who.int)

Data from the current National Surveillance program in Denmark (DANMAP) may not accurately represent the prevalence of resistant E. coli in primary care, because only urine samples from complicated cases may be forwarded to the microbiological departments at hospitals for diagnostic examination. (ku.dk)
The aim of this study was to assess the prevalence of resistant E. coli to the most commonly used antimicrobial agents in primary care in a consecutive sample of patients from general practice. (ku.dk)
A surveillance study reported that the prevalence of rectal colonization by ESBL-producing Enterobacteriaceae among newly-hospitalized general medical patients in an Israel teaching hospital was only 8% [ 9 ]. (biomedcentral.com)

Pre-Extensively Drug-resistant TB (pre-XDR TB) is a type of MDR TB caused by TB bacteria that are resistant to isoniazid, rifampin, and a fluroquinolone OR by TB bacteria that are resistant to isoniazid, rifampin, and a second-line injectable (amikacin, capreomycin, and kanamycin). (cdc.gov)
Extensively drug-resistant TB (XDR TB) is a rare type of MDR TB that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable second-line drugs (i.e., amikacin, kanamycin, or capreomycin). (cdc.gov)
Extensively drug-resistant TB (XDR-TB) represents an emerging public health problem worldwide. (who.int)

BOSTON, Oct 28, 2003 (BUSINESS WIRE) -- Gilead Sciences (Nasdaq:GILD) today announced that treatment with its once-daily, oral antiviral agent Hepsera(R) (adefovir dipivoxil 10 mg) was associated with sustained reductions in levels of hepatitis B virus (HBV) DNA through 144 weeks (approximately three years) among patients chronically infected with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
Study 460i is a single-center, open-label study of Hepsera in chronic hepatitis B patients with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
Lamivudine-resistant HBV (confirmed "YMDD" mutation) was detected in patients a median of 21.3 months prior to initiating treatment with Hepsera. (gilead.com)
Akima T, Tamano M, Yamagishi H, Kubota K, Fujimori T, Hiraishi H. Surgical treatment of HCC in a patient with lamivudine-resistant hepatitis B cirrhosis with adefovir dipivoxil. (wjgnet.com)

We collected clinical information on 17 patients seen at a New York City hospital who had repeatedly positive cultures for Mycobacterium tuberculosis. (nih.gov)

Target bacteria included extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), carbapenem-resistant- P.aeruginosa (CR-PA), carbapenem-resistant- A.baumannii (CR-AB) and methicillin-resistant S.aureus (MRSA). (biomedcentral.com)
Nasal colonization by methicillin-resistant Staphylococcus aureus (MRSA) has been widely investigated. (biomedcentral.com)

Antimicrobial resistant microorganisms are found in people, animals and the environment and can spread globally. (who.int)

Several patients were up-staged from non-metastatic CRPC (nmCRPC) to metastatic CRPC (mCRPC). (uzh.ch)
Remembering of course that we are going to try to intensify for all patients with metastatic hormone-sensitive disease, our patients are going to have been exposed to more than just ADT [androgen deprivation therapy] alone by the time they hit first-line mCRPC status, for most patients. (medpagetoday.com)
And if a patient has bone-only metastatic disease and has some symptomatology, even if that's just an anemia or some mild fatigue, then radium can be an option there as well. (medpagetoday.com)

The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine is associated with rapid but transient antidepressant effects in patients with treatment resistant unipolar depression (TRD). (mssm.edu)

Sometimes drug-resistant TB occurs when bacteria become resistant to the drugs used to treat TB. (cdc.gov)
Drug-resistant TB is caused by TB bacteria that are resistant to at least one first-line anti-TB drug. (cdc.gov)

Bardelli and his colleagues analyzed tumors from seven patients who developed resistance subsequent to anti-EGFR therapy, and identified three who did not have the previously known mutations. (medindia.net)
In five other patients, however, the RFLP patterns of the isolates changed dramatically at the time that drug resistance was detected. (nih.gov)
Resistance to antituberculous drugs can develop not only in the strain that caused the initial disease, but also as a result of reinfection with a new strain of M. tuberculosis that is drug-resistant. (nih.gov)
The development of resistance - which emerges in up to 90 percent of immunocompromised HBV-infected patients after four years of therapy with lamivudine - can lead to progression of chronic hepatitis B," said Dr. Benhamou. (gilead.com)
Antiretroviral drug resistance has long challenged patients and providers on the path to viral suppression. (primeinc.org)
Individualized longer regimens, which should contain bedaquiline as a prioritized drug, are recommended for patients with extensive TB disease, severe forms of extrapulmonary TB, those with resistance to fluoroquinolones, or who have been exposed to treatment with second-line drugs. (jnj.com)
Standard care in any phase often includes more than 1 medication, which implies some degree of resistance in most patients. (health.am)
1, 2 Clinical drug resistance is becoming of increasing importance worldwide and is attributed to factors including patient non-adherence to treatment, inappropriate treatment regimens, drug malabsorption, and a poor health infrastructure needed for the effective delivery of treatment. (bmj.com)
The most difficult clinical cases are caused by multiple drug resistant tuberculosis (MDRTB) defined as resistance to at least isoniazid and rifampicin. (bmj.com)
These drugs constitute the mainstay of treatment and knowledge of resistance is likely to be of direct benefit to the individual patient and to public health TB programmes. (bmj.com)
Virologists found the rare mrc-1 gene, which causes the resistance, in a strain of E. coli from a patient in New York, according to findings published in the journal Antimicrobial Agents and Chemotherapy. (seeker.com)
The novel mechanism of action provides a new treatment to patients with limited options, with no drug-drug interactions or known risk of cross resistance," said Jacob Lalezari, MD, lead author of the study and medical director for Quest Research, located in San Francisco, California. (contagionlive.com)
To be included, patients needed to have a HIV-1 viral load exceeding 1000 copies/mL, had to have been receiving antiretroviral therapy for at least 6 months, and had to have documented resistance to at least one antiretroviral drug from three classes. (contagionlive.com)
The collaborative efforts of Hu-Lieskovan and Bernards seek to identify genes that help cancers become resistant to immunotherapy, with the goal to facilitate the development of new and more effective combination therapies that can overcome this resistance. (uclahealth.org)
Of those, 15 cases (17.9%) had ofloxacin resistance and 6.0% were resistant to kanamycin and capreomycin. (who.int)
Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
The resistant isolates showed different restriction profiles when the amplified kDNA PCR products were digested with ALU1 restriction enzyme, indicating that resistance was mediated by different parasite clones. (who.int)
Gram negative isolates showed high resistance rate of 73.1% to ampicillin and 65.4% to amoxicillin-clavulanic acid while Gram-positive isolates showed high resistant rate of 94.1% to penicillin. (who.int)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

This disrupts our microbiome, allowing the surviving pathogens, which are often resistant to the treatment, to dominate our microbiome. (cdc.gov)
Some of the surviving pathogens are often resistant to the treatment. (cdc.gov)
When patients are colonized, a unique patient safety intervention called pathogen reduction and decolonization can remove the colonized pathogens in a patient's microbiome, such as skin, nose, or gut. (cdc.gov)
The isolation of bacterial pathogens resistant to the commonly prescribed antibiotics from pregnant women symptomatic and asymptomatic for UTI calls for early screening of all pregnant women for UTI during antenatal care service delivery. (who.int)
Pneumonia in immunocompromised patients is often caused by unusual pathogens but may also be caused by the same pathogens that cause community-acquired pneumonia. (msdmanuals.com)

Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)

Carbapenem-resistant P. aeruginosa (CRPA) isolates in Idaho intensive care unit (ICU) room (room X), 4 months apart. (cdc.gov)
In 18,852 wound smears of 697 injured patients, P. aeruginosa was found in 7,650 cases. (who.int)
Bacterial cultures taken from the environment of patients included P. aeruginosa in only 6.7% mostly type 5. (who.int)

All CPE isolates carrying either bla OXA-232 or bla NDM-1 were resistant to meropenem, but only 40 from 45 were susceptible to colistin. (biomedcentral.com)

The differences in patient characteristics between the 2 groups and predictors of patients who have at least 1 68 Ga-PSMA−, 18 F-FDG+ lesion were analyzed. (snmjournals.org)
Gleason score and PSA are significant predictors of 68 Ga-PSMA−, 18 F-FDG+ lesions, and CRPC patients with a high Gleason score and PSA may benefit from additional 18 F-FDG PET/CT. (snmjournals.org)

After not responding to medications, psychotherapy, and neuromodulatory interventions like vagus nerve stimulation or transcranial magnetic stimulation, some people with treatment-resistant depression experience debilitating illness and have few further treatment options. (psychiatrist.com)

Unfortunately, patients whose tumors recur after anti-EGFR therapy are out of further options currently," said Bardelli. (medindia.net)
Using "xenopatients" patient-derived, drug-resistant colorectal cancers grafted and grown in mice the researchers identified a novel, biologically distinct subset of tumors that were resistant to anti-EGFR drugs and did not have alterations in KRAS, BRAF or NRAS but carried MET amplification. (medindia.net)

Last month, the Centers for Disease Control and Prevention (CDC) announced the establishment of a network of labs that would respond quickly to antibiotic-resistant superbugs in the United States. (seeker.com)

No patients in 2 of the 5 study cohorts were on antiretroviral therapy. (cdc.gov)
Blood samples collected at regular intervals during treatment with anti-EGFR therapy until relapse were available for two of the three patients. (medindia.net)
In this study, co-infected patients who received Hepsera showed sustained suppression of HBV through nearly three years of therapy. (gilead.com)
Approximately 46 percent of patients had undetectable HBV DNA levels (less than 3.0 log(10) copies/mL) after nearly three years of therapy. (gilead.com)
For truly resistant conditions, clozapine and electroconvulsive therapy (ECT) are also recommended for depression and mania in both acute and maintenance treatment. (health.am)
The team treated 9 such patients with DBT and "conjoint" magnetic seizure therapy (MST) for 5 weeks, and compared impacts on their symptoms-especially suicidal ideation and depression, as well as cognitive performance-with 10 similar patients who received only DBT for 5 weeks. (bbrfoundation.org)
This will not be a first- or second-line therapy for those who are infected with HIV, but it may be helpful for certain patients. (contagionlive.com)
Health care providers can help prevent drug-resistant TB by quickly diagnosing cases, following recommended treatment guidelines, monitoring patients' response to treatment, and making sure therapy is completed. (cdc.gov)
Because of that, it's really critical to recognize what a patient has had before and try to switch mechanism of action, particularly if that patient has had intensified therapy with an AR [androgen receptor]-targeted agent. (medpagetoday.com)
Objectives: We present three patients with therapy resistant peristomal dermatitis, suggesting ACD caused by different stoma products. (lu.se)
Conclusion: Therapy resistant peristomal dermatitis should always be suspected of ACD and patch testing, especially with the patient's own products, should be performed. (lu.se)

We have reviewed a total of 33 patients with recurrent platinum-resistant EOC from July 2017 to July 2018, who were regularly treated with apatinib and etoposide until disease progression or unacceptable toxic effects occurred. (jcancer.org)

Currently, no clear consensus exists regarding treatment response assessment in PSMA-PET scans for mCRPC patients undergoing treatment. (uzh.ch)

Healthcare providers are at risk for contracting it during a bronchoscopy or getting a sputum specimen from an infected patient. (medleague.com)
However, immunocompromised patients may have no fever or respiratory signs and are less likely to have purulent sputum if they are neutropenic. (msdmanuals.com)
Sputum testing should include Gram stain, mycobacterial and fungal stains and cultures, and sometimes testing for viruses (eg, polymerase chain reaction for cytomegalovirus in a transplant patient or in a patient with AIDS). (msdmanuals.com)

This was a retrospective cross-sectional study that included 218 patients admitted to An-Najah National University Hospital between January 1, 2021, and May 31, 2022. (bvsalud.org)

Neurostimulation represents a more invasive option that can be helpful in highly refractory patients. (psychiatrictimes.com)
2 DBS was discovered to diminish affective symptoms serendipitously and is undergoing investigation for applications in patients with psychiatric illness, especially those with refractory obsessive-compulsive disorder or affective illness. (psychiatrist.com)

in immunocompetent patients. (msdmanuals.com)

This study looked at whether a type of nutrient known as resistant starch could lower the risk of cancers in people with Lynch Syndrome. (facingourrisk.org)
Researchers found that resistant starch can reduce the risk of non-colorectal cancers but not colorectal cancer. (facingourrisk.org)
UCLA researcher Dr. Siwen Hu-Lieskovan has been awarded the Phillip A. Sharp Innovation in Collaboration Award from Stand Up To Cancer (SU2C) to fund her work using genomics to better understand how melanoma and other cancers can become resistant to immunotherapy. (uclahealth.org)

The data of 56 patients with CRPC who underwent both 68 Ga-PSMA and 18 F-FDG PET/CT from May 2018 to February 2021 were retrospectively analyzed. (snmjournals.org)

So if we're changing mechanism of action, how do we choose well for asymptomatic patients, minimally symptomatic patients. (medpagetoday.com)

Therefore, our study aimed to describe the epidemiology and clinical characteristics of patients with carbapenem-resistant Enterobacteriaceae in a referral hospital in a developing country . (bvsalud.org)

The change in the RFLP pattern of the isolate from one patient appeared to be the result of contamination during processing in the laboratory. (nih.gov)

For patients who have visceral crisis, cord compression, something that is really dramatically an event that's rapidly progressive, chemotherapy is still probably the best approach. (medpagetoday.com)

antipsychotics were reserved for resistant, severely ill, or psychotic patients. (health.am)

We determined the added value of 18 F-FDG PET/CT compared with 68 Ga-PSMA PET/CT in CRPC patients and identified CRPC patients who may benefit from additional 18 F-FDG PET/CT. (snmjournals.org)
Additionally, illustrative cases of CRPC patients from our own institution who were restaged and treated based on PSMA-PET scan results are provided. (uzh.ch)
PSMA-guided metastasis-directed radiotherapy may not only alleviate local symptoms but has the potential to defer systemic treatment in patients with oligoprogressive CRPC. (uzh.ch)
Until future studies define the role of PSMA-PET in patients with CRPC, the current standard for imaging remains bone scan and computerized tomography. (uzh.ch)

Current control of visceral leishmania- is associated with high morbidity and mor- sis is based on case detection and treat- tality of untreated patients. (who.int)

Moreover, treatment is prolonged, adverse events are common, and the majority of affected patients do not receive adequate treatment. (ingentaconnect.com)
The most common adverse event was mucositis oral (60.6%), which caused the treatment discontinued in 4 (12.1%) patients. (jcancer.org)
No patient discontinued treatment and no serious adverse events occurred. (contagionlive.com)

Six patients had isolates that remained drug-susceptible, and the RFLP patterns of these isolates did not change over time. (nih.gov)
Drug-resistant TB (DR TB) is spread the same way that drug-susceptible TB is spread. (cdc.gov)

Forslund T, Wettermark B, Andersen M, Hjemdahl P. Stroke and bleeding with NOAC or warfarin treatment in patients with non-valvular atrial fibrillation: a population based cohort study. (janusinfo.se)
Loikas D, Forslund T, Wettermark B, Schenck-Gustafsson K, Hjemdahl P, von Euler M. Increased thromboprophylactic treatment in patients with atrial fibrillation after the introduction of NOACs - an analysis of sex and gender differences. (janusinfo.se)

The median baseline serum HBV DNA level in these patients was 8.75 log(10) copies/mL (Roche Amplicor(TM) Monitor PCR). (gilead.com)
Median survival in patients treated with three drugs to which the bacterium was susceptible on in vitro testing (n=62) was 2066 days (95% CI 1336 to 2515) or 5.66 years, whereas in those not so treated (n=13) survival was 599 days (95% CI 190 to 969) or 1.64 years. (bmj.com)
Therefore, a total of 97/177 patients (54.8%) remained on treatment as of June 2021 (duration of treatment 17-30 months, median of 25 months). (biomedcentral.com)

The diagnosis of patients with MDR-TB will be relocated from the National TB Centre to the National Reference Laboratory. (fondation-merieux.org)
A diagnosis requires that the patient meet general diagnostic criteria for a personality disorder, as defined in the DSM-5 manual. (bbrfoundation.org)

Experimental treatments such as deep brain stimulation (DBS), an invasive neurosurgical intervention, could be considered for individuals with treatment-resistant depression. (psychiatrist.com)
these agents can now be considered first-line treatments even for moderately ill manic patients. (health.am)
Others have required multiple trials of combinations or that patients fail to respond to nonstandard treatments, such as antidepressants. (health.am)
In contrast, prior to the start of treatment, the existing treatments had been similarly effective related to treatment in only one patient. (contagionlive.com)
However, only about 60% of patients respond to those treatments to any significant degree. (nature.com)
Many migraine patients do not respond adequately to conventional preventive treatments and are therefore described as treatment/medically resistant or difficult to treat cases. (biomedcentral.com)
The term treatment resistant migraine is used to describe patients with persistent headache and associated migraine symptoms who fail to respond to multiple conventional migraine preventive treatments (typically three agents). (biomedcentral.com)
Comparing Treatments for Resistant Kawas. (pcori.org)

The purpose of this study was to evaluate the susceptibility of HSV isolated from normal subjects and patients with acquired immunodeficiency syndrome (AIDS) to ACV. (unboundmedicine.com)
HSVs were isolated from the orofacial region of normal individuals and patients with AIDS. (unboundmedicine.com)
One hundred and thirty-three isolates from 102 normal subjects and 31 patients with AIDS were tested. (unboundmedicine.com)
or = 5 microg/mL, were detected in patients with AIDS. (unboundmedicine.com)

Joint guidelines for the use of antimicrobial agents for prophylaxis and treatment in neutropenic cancer patients have been issued by the American Society of Clinical Oncology (ASCO) and the Infectious Diseases Society of America (IDSA). (medscape.com)
Antifungal prophylaxis with an oral triazole or parenteral echinocandin is recommended for patients who are at risk for profound, protracted neutropenia, such as most patients with acute myeloid leukemia/myelodysplastic syndromes or HSCT. (medscape.com)

In line with treatment guidelines released by WHO in March 2019, bedaquiline remains a "Group A" medicine for long-course regimens for patients with pulmonary MDR-TB. (jnj.com)
Johnson & Johnson is committed to working closely with countries and partners to continue scaling up access to bedaquiline for more patients, building on significant and rapid progress in 2019. (jnj.com)

A second US patient has been infected with a superbug that is highly resistant to last-resort antibiotics, scientists said Monday. (seeker.com)

The study involved 12,539 patients from low-, middle- and high-income countries, according to the U.N.'s Human Development Index (HDI). (naturalnews.com)
A recent retrospective cohort study from a 1200-bed university hospital in Bangkok reported on an increased incidence of CPE from 3.37 per 100,000 patient-days in 2011 to 32.49 per 100,000 patient-days between 2011 and 2016 [ 4 ]. (biomedcentral.com)
This study aimed to assess the efficacy and safety of apatinib combined with etoposide in patients with recurrent platinum-resistant EOC. (jcancer.org)
This drug benefits a small but challenging population of HIV patients who are highly treatment experienced," said Daniel R. Kuritzkes, MD, chief of the Division of Infectious Diseases at Brigham and Women's Hospital and professor of medicine at Harvard Medical School, Boston, during a press briefing to present the study findings. (contagionlive.com)
This study aimed to explore and compare MDR-TB patients' experiences of their diagnostic and treatment initiation pathway in GenoType MTBDRplus and Xpert® MTB/RIF-based diagnostic algorithms. (sun.ac.za)
Hu-Lieskovan has used a variety of genetic approaches to collect and study tumor and blood samples from patients who have received anti-PD1 immunotherapies. (uclahealth.org)
We performed a prospective surveillance study in hospitalized patients at Siriraj Hospital. (biomedcentral.com)
This study will assess whether minocycline, an antibiotic with anti-inflammatory effects, can improve blood pressure control in patients who do not respond to medicines in combination with lifestyle changes, such as physical activity, weight loss, and healthy eating patterns. (nih.gov)
The study included 103 children ages 4 weeks to 17 years with resistant Kawasaki disease. (pcori.org)
We randomly recruited 820 visceral sistance to amphotericin B and pentamidine leishmaniasis patients to the study from has been observed [ 5 ]. (who.int)
Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)

In addition, 21.6 percent of 610 patients with SSI had one that is resistant to prophylactic antibiotics. (naturalnews.com)

Anatomy11

Organisms34

Diseases19

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes65

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care5

Castration-resistant prostate cancer9

Infections29

Strains9

Infection15

Outcomes for patients1

Multidrug14

Prevalence3

Extensively Drug-Resistant TB3

Lamivudine-resistant4

Mycobacterium1

Methicillin-resistant2

Antimicrobial resistant1

Metastatic3

Unipolar depression1

Bacteria2

Resistance20

Pathogens5

Methods1

Aeruginosa3

Colistin1

Predictors2

Transcranial magnetic st1

Tumors2

Superbugs1

Therapy11

20171

MCRPC1

Sputum3

20221

Refractory2

Immunocompetent1

Cancers3

20181

Symptomatic1

Characteristics1

Isolate1

Chemotherapy1

Severely ill1

CRPC4

Morbidity1

Adverse3

Drug-susceptible2

Treatment in Patients2

Median3

Diagnosis2

Treatments8

AIDS4

Prophylaxis2

Bedaquiline2

Highly resistant1

Study11

Prophylactic1