• Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant? (nih.gov)
  • Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
  • The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
  • Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
  • See Acute Lymphoblastic Leukemia Staging for more complete information. (medscape.com)
  • Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
  • Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
  • Cytogenetic studies performed on bone marrow provide important prognostic information and can guide treatment by confirming a diagnosis of acute promyelocytic leukemia (APL). (medscape.com)
  • Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC. (medscape.com)
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
  • The natural process of blood cell formation, hematopoietic stem cell differentiation, and generation of myeloid and lymphoid cell lineages. (oncomine.com)
  • Flow cytometry of the bone marrow revealed that the blast cells expressed B lymphoid lineage associated antigens (Figure 1 ) and hence the patient was diagnosed with pre-B ALL. (cambridgemedicine.org)
  • At the end of induction the bone marrow was hypercellular with 6% myeloid blasts by flow cytometry but no excess of lymphoid blasts (Figure 2 ). (cambridgemedicine.org)
  • Flow cytometry found 32% myeloid blasts and immature B cells with a similar phenotype to the lymphoid blasts found at diagnosis. (cambridgemedicine.org)
  • 5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
  • These blasts were large with basophilic cytoplasm and no granulation. (cambridgemedicine.org)
  • The myeloid blasts expressed CD34, CD13, CD33, CD117 and HLA-DR. The analysis for minimal residual disease (MRD) was as low risk. (cambridgemedicine.org)
  • 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
  • An aggressive disease (rapid onset and progression) that occurs primarily in adulthood and is marked by an abnormal increase and accumulation of myeloblasts (immature myeloid cells) in the bone marrow and blood, which leads to impaired hematopoiesis and bone marrow failure. (oncomine.com)
  • Addressing the CDKN2A/2B deletions' additive prognostic effect in current risk-stratification algorithms, we present a retrospective study of a Greek pediatric ALL cohort comprising 247 patients studied over a 24-year period (2000-2023). (bvsalud.org)
  • In multivariate analysis, the presence of the CDKN2A/2B deletions was the most important prognostic factor for relapse and overall survival, yielding a hazard ratio of 5.2 (95% confidence interval: 2.59-10.41, p (bvsalud.org)
  • Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. (nih.gov)
  • Panobinostat triggered terminal myeloid differentiation via proteasomal degradation of A/E9a. (ashpublications.org)
  • Lymph node swelling is rare in most types of AML, except for acute myelomonocytic leukemia (AMML). (wikipedia.org)
  • The peripheral monocytosis leads us to believe that this patient may have transformed via a juvenile myelomonocytic leukaemia (JMML) which subsequently transformed into a refractory AML. (cambridgemedicine.org)
  • Myeloid malignancies arise from mutations in hematopoietic stem or progenitor cells. (oncomine.com)
  • In approximately 15% of patients, however, myelofibrosis is accompanied by significant extramedullary hematopoiesis, hepatosplenomegaly, and transfusion-dependent anemia, which are manifestations of stem cell failure. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • The patient was given salvage chemotherapy in the form of FLA-Ida with the plan to reassess at count recovery aiming for stem cell transplant. (cambridgemedicine.org)
  • 1,2 Consequently, the clinical value of next-generation sequencing (NGS) is most apparent today in myeloid molecular testing. (oncomine.com)
  • 3 Results can be available within hours or days, depending on the platform.3 With its demonstrated clinical utility in myeloid malignancies, NGS is transforming the testing paradigm and enabling better outcomes for patients. (oncomine.com)
  • Although early phase clinical assessment indicated that treatment with HDAC inhibitors (HDACis) may be effective in t(8;21) AML patients, rigorous preclinical studies to identify the molecular and biological events that may determine therapeutic responses have not been performed. (ashpublications.org)
  • Daratumumab plus lenalidomide and dexamethasone for relapsed POEMS syndrome with bone plasmacytoma harboring 17p deletion. (u-tokyo-hemat.com)
  • The patient commenced induction with regimen A of the UKALL2011 trial which includes treatment with vincristine, pegaspargase and dexamethasone. (cambridgemedicine.org)
  • T-cell depleted allogeneic hematopoietic cell transplants as a platform for adoptive therapy with leukemia selective or virus-specific T-cells. (nih.gov)
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (wikipedia.org)
  • Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
  • Two months later the bone marrow aspirate indicated refractory disease with 30-50% blasts and a reduced number of mature myeloid cells and abnormal monocytoid cells. (cambridgemedicine.org)
  • 90% of reported cases is prolonged and profound neutropenia in patients with acute leukemia ( 6 , 7 , 9 ). (cdc.gov)
  • In recent years, the frequency of opportunistic fungal infections has increased in parallel with the growing number of patients receiving aggressive chemotherapy ( 1 , 2 ). (cdc.gov)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
  • Epigenetic modifying enzymes such as histone deacetylases (HDACs), p300, and PRMT1 are recruited by AML1/ETO, the pathogenic protein for t(8;21) acute myeloid leukemia (AML), providing a strong molecular rationale for targeting these enzymes to treat this disease. (ashpublications.org)
  • 1,3 Associated delays in obtaining results can postpone diagnosis and treatment, negatively impact disease management, and be stressful for patients. (oncomine.com)
  • Of course, in patients with associated acid-peptic disease, occult gastrointestinal bleeding may lead to a presentation with hypochromic, microcytic anemia, masking the presence of PV. (basicmedicalkey.com)
  • Echocardiography or multiple gated acquisition (MUGA) scanning is particularly important for patients who have a history or symptoms of heart disease or risk factors for iatrogenic cardiotoxicity (ie, exposure to cardiotoxic drugs or thoracic radiotherapy). (medscape.com)
  • Multiple intensive combination chemoimmunotherapy regimens have demonstrated excellent efficacy in this disease, although treatment toxicity remains a challenge in many patients. (cancernetwork.com)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • Up-regulation of VEGF and its receptor in refractory leukemia cells. (nih.gov)
  • On examination the patient had smooth hepatosplenomegaly and lymphadenopathy in the supraclavicular, infraclavicular, axillary and inguinal regions. (cambridgemedicine.org)
  • The results of our study demonstrate that the presence of the CDKN2A/2B deletions can further stratify all existing risk groups, identifying patient subgroups with different outcomes. (bvsalud.org)
  • Myeloproliferative neoplasms present with the clonal proliferation of 1 or more myeloid cell lineages.10 The role of genetic and genomic aberrations in pathogenesis has been well documented for these disorders. (oncomine.com)
  • Patients with massive splenomegaly are particularly prone to thrombotic events because the associated increase in plasma volume masks the true extent of the red cell mass elevation measured by the hematocrit or hemoglobin level. (basicmedicalkey.com)
  • A "normal" hematocrit or hemoglobin level in a PV patient with massive splenomegaly should be considered indicative of an elevated red cell mass until proven otherwise. (basicmedicalkey.com)
  • The use of salicylates as a tonic against thrombosis in PV patients is not only potentially harmful if the red cell mass is not controlled by phlebotomy, but is also an unproven remedy. (basicmedicalkey.com)
  • Patients with AML can have high, normal, or low white blood cell (WBC) counts. (medscape.com)
  • P. Connor Johnson, MD, and Jeremy S. Abramson MD, MMSc, discuss available treatments for patients with Burkitt lymphoma and high-grade B-cell lymphoma. (cancernetwork.com)
  • [ 19 ] All patients should have a baseline electrocardiogram before starting treatment for AML. (medscape.com)
  • Some of the central nervous system symptoms observed in patients with PV, such as ocular migraine, appear to represent a variant of erythromelalgia. (basicmedicalkey.com)
  • In patients with signs or symptoms suggesting central nervous system (CNS) involvement, computed tomography (CT) or magnetic resonance imaging (MRI) should be performed. (medscape.com)
  • Most patients with AML have an elevated lactate dehydrogenase (LDH) level and, frequently, an elevated uric acid level. (medscape.com)
  • With an ever-growing list of biomarkers, inherent genetic complexity, and the risk of rapid progression, myeloid malignancies challenge the current iterative testing paradigm and call for a streamlined testing approach that yields rapid results. (oncomine.com)
  • UKALL2011 R2 randomisation was declined, so the patient received standard IM and pulses for maintenance therapy. (cambridgemedicine.org)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Lumbar puncture is indicated in those patients if no CNS mass or lesion is detected on CT or MRI. (medscape.com)
  • Appropriate cultures should be obtained in patients with fever, or with signs of infection even in the absence of fever. (medscape.com)