Patients with recurrent ovarian epithelial cancer fallopian tube neoplasms. Medical search. Frequent questions

Evidence is insufficient as of 2020 to support its use in primary advanced epithelial ovarian, fallopian tube or primary peritoneal carcinoma, recurrent ovarian cancer, peritoneal colorectal carcinomatosis, gastric peritoneal carcinomatosis, malignant peritoneal mesothelioma, or disseminated mucinous neoplasm of the appendix. (wikipedia.org)
However, investigators have demonstrated precursor cancerous lesions in the fallopian tube (tubal in-situ carcinoma [TIC]) and have provided evolutionary evidence that many advanced serous ovarian cancers originate in the fallopian tubes. (medscape.com)
The larger expectation for improved prognosis in ovarian carcinoma is related to the use of the new biological agents. (biomedcentral.com)
Primary lesions include epithelial ovarian carcinoma (70% of all ovarian malignancies). (medscape.com)
However, as explained below, recent morphologic findings and molecular analyses have demonstrated that each morphologic subtype of ovarian carcinoma might be derived from a Müllerian-type epithelium. (biomedcentral.com)
Prognostic factors in ovarian carcinoma stage III patients. (bmj.com)
Epithelial carcinoma. (cancer.net)
Epithelial carcinoma makes up 85% to 90% of ovarian/fallopian tube cancers. (cancer.net)
Patients must have histologically or cytologically confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. (survivornet.com)
This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma , endometrial adenocarcinoma , and urothelial carcinoma based on Acrivon's OncoSignature® test status. (ucsd.edu)
Biochemical recurrence (eg, CA-125 in ovarian carcinoma ) only is not considered as disease progression. (ucsd.edu)
The purpose of this case-control study was to compare the prognoses of women with stage III mucinous ovarian carcinoma (MOC) who received maximal or optimal cytoreduction followed by paclitaxel plus carboplatin chemotherapy to those of women with stage III serous epithelial ovarian cancer (EOC) treated in the similar manner. (biomedcentral.com)
We investigated series of immune- and gen-aberration-tests: a molecular analysis by gene-panel Oncomine Focus® using Ion Torrent platform showed the typical genetic features of low-grade serous ovarian carcinoma including KRAS-mutation (c.35G>T) p.G12V, exon 2, but no other specific marker has been found except for a c-MYC amplification. (sciencerepository.org)
He is currently funded by NIH to evaluate the potential use of Clostridium Perfringens Enterotoxin (CPE) as a novel therapy against chemotherapy resistant ovarian carcinoma. (yale.edu)
OBJECTIVE: Inhibition of the MAPK pathway by MEK inhibitors (MEKi) is currently a therapeutic standard in several cancer types, including ovarian low-grade serous carcinoma (LGSC). (bvsalud.org)
A common MAPK pathway alteration in tubo-ovarian high-grade serous carcinoma (HGSC) is the genomic inactivation of neurofibromin 1 (NF1). (bvsalud.org)
The primary objectives of our study were to survey the prevalence of NF1 inactivation in the principal ovarian carcinoma histotype as well as to evaluate its associations with clinico-pathological parameters and key biomarkers including BRCA1/2 status in HGSC. (bvsalud.org)
METHODS: A recently commercialized NF1 antibody (clone NFC) was orthogonally validated on an automated immunohistochemistry (IHC) platform and IHC was performed on tissue microarrays containing 2140 ovarian carcinoma cases. (bvsalud.org)
High-grade serous ovarian carcinoma (HGSOC) is characterised by poor outcome and extreme chromosome instability (CIN). (bvsalud.org)
Fallopian tube carcinoma that progresses during platinum therapy or within one month of completing the last platinum therapy. (nih.gov)
To define molecular and biochemical profiles associated with the duration of progression-free survival in platinum-sensitive recurrent ovarian, peritoneal primary or fallopian tube carcinoma treated with combination chemotherapy with or without bevacizumab followed with or without maintenance bevacizumab therapy in the presence or absence of secondary surgical cytoreduction. (ucsf.edu)

If ovarian cancer spreads, cancerous tumors most often appear in the abdominal cavity or on the surfaces of nearby organs such as the bladder or colon. (medlineplus.gov)
Tumors that begin at one site and then spread to other areas of the body are called metastatic cancers. (medlineplus.gov)
First-line treatment (in combination with erlotinib) of metastatic non-small cell lung cancer in patients whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations. (southcarolinablues.com)
Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Studies have shown that epithelial ovarian cancer is not a single disease but is composed of a diverse group of tumors that can be classified based on distinctive morphologic and molecular genetic features [ 1 ]. (biomedcentral.com)
Malignant mixed mesodermal tumors (carcinosarcomas) are included in the type II category because their epithelial components are identical to the pure type II carcinomas. (biomedcentral.com)
In terms of origin of ovarian cancer, many of researchers and gynecologic oncologists have traditionally understood that the various different ovarian tumors are all derived from the ovarian surface epithelium (mesothelium) and that subsequent metaplastic changes lead to the development of the different cell types (Table 2 ). (biomedcentral.com)
Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
Tumors or cancer of the human BREAST. (lookformedical.com)
Tumors or cancer of the OVARY. (lookformedical.com)
Characteristically the tumor tends to occur at an earlier than average age, individuals may have more than one primary tumor, the tumors may be multicentric, usually more than 25 percent of the individuals in direct lineal descent from the proband are affected, and the cancer predisposition in these families behaves as an autosomal dominant trait with about 60 percent penetrance. (lookformedical.com)
Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. (lookformedical.com)
This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. (medscape.com)
Thus, type I (low-grade serous G1, low-grade endometrioid G1/G2, mucinous or clear cell) tumors are associated with corresponding benign ovarian cystic neoplasms, often developing through an intermediate borderline step and have a better prognosis. (spandidos-publications.com)
The term "Krukenberg tumor" is used in practice to include all metastatic ovarian tumors although only 40% of ovarian metastases are due to Krukenberg tumor which is a signet cell gastrointestinal malignancy [1]. (symptoma.com)
Krukenberg tumors are associated with bilateral, asymmetrical enlargement of the ovaries without peritoneal adhesions and deposits while metastases from other tumors are embedded within the ovarian capsule or in the peritoneum [1]. (symptoma.com)
Twaalhoven 1999,Houck 2000, Tempfer 2007, Brun 2008 Accuracy for malignancy of epithelial OvTu 90-94% Accuracy for borderline tumors approx. (symptoma.com)
Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potentiel. (biomedcentral.com)
These tumors are subdivided into three main categories: epithelial, germ cell, and sex-cord stromal tumors. (biomedcentral.com)
According to the 2014 World Health Organization (WHO) classification and tumor morphology, primary ovarian tumors are subdivided into three categories: epithelial (60%), germ cell (30%), and sex-cord stromal tumors (8%)[ 1 ]. (biomedcentral.com)
However, the vast majority of malignant ovarian tumors (80%-85%) are classified as epithelial tumors (carcinomas). (biomedcentral.com)
Malignant germ cell and sex-cord stromal tumors comprise approximately 10% of all malignant ovarian tumors. (biomedcentral.com)
Ovarian tumors account for a considerable proportion of clinically relevant neoplasms in females, exhibiting a wide range of age at presentation (from infant to elderly patients). (biomedcentral.com)
Approximately two-thirds of ovarian tumors occur in women during reproductive age, whereas less than 5% occur in children. (biomedcentral.com)
Approximately 75%-80% of ovarian tumors are benign, occurring in patients under 40 years of age. (biomedcentral.com)
In contrast, 80%-90% of ovarian carcinomas are detected after the age of 40, and 40% of these tumors are detected after the age of 65. (biomedcentral.com)
Ovarian epithelial tumors are subclassified into several categories based on two criteria: 1) the degree of epithelial proliferation and invasion and 2) the histotype of the epithelium composing the tumor. (biomedcentral.com)
Benign epithelial tumors (adenoma and cystadenoma) are characterized by the absence of cell proliferation and invasion. (biomedcentral.com)
These tumors represent 60% of all epithelial tumors. (biomedcentral.com)
They represent 30% of all epithelial tumors and 80%-85% of all ovarian cancers. (biomedcentral.com)
These tumors are primarily found in elderly patients with a median age of 60 years. (biomedcentral.com)
Diagnosing hereditary tumors enable to predict the types of cancer that may develop in the future. (ejgo.net)
Diagnosis of hereditary tumors may also change the cancer treatment strategy for the diagnosed patient. (ejgo.net)
Food and Drug Administration approved the combination of nivolumab (OPDIVO, Bristol-Myers Squibb Co.) plus ipilimumab (YERVOY, Bristol-Myers Squibb Co.) as first-line treatment for patients with metastatic non-small cell lung cancer whose tumors express PD-L1(≥1%), as determined by an FDA-approved test, with no epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) genomic tumor aberrations. (blogspot.com)
Food and Drug Administration granted accelerated approval to capmatinib (TABRECTA, Novartis) for adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation that leads to mesenchymal-epithelial transition (MET) exon 14 skipping as detected by an FDA-approved test. (blogspot.com)
Patients with MOC seem to be 2.3 times more likely to die of their tumors when compared to women with serous EOC. (biomedcentral.com)
Unraveling how cancer cells stop the immune system from recognizing tumors as dangerous. (benaroyaresearch.org)

In this form of cancer, certain cells in the ovary become abnormal and multiply uncontrollably to form a tumor . (medlineplus.gov)
These cancers can arise in the epithelial cells on the surface of the ovary. (medlineplus.gov)
However, researchers suggest that many or even most ovarian cancers begin in epithelial cells on the fringes (fimbriae) at the end of one of the fallopian tubes, and the cancerous cells migrate to the ovary. (medlineplus.gov)
Malignant ovarian lesions include primary lesions arising from normal structures within the ovary and secondary lesions from cancers arising elsewhere in the body. (medscape.com)
Epithelial neoplasms of the ovary are thought to arise either directly or indirectly from the ovarian surface epithelium according to incessant ovulation theory[ 4 ]. (biomedcentral.com)
During ovulation, which typically happens monthly, an egg is usually released from 1 ovary and travels through a fallopian tube to the uterus. (cancer.net)
The term "ovarian cancer" is often used to describe cancers that begin in the cells in the ovary, fallopian tube, or peritoneum. (cancer.net)
An ovarian cyst is an abnormal growth of tissue that forms on the surface of the ovary and includes fluid. (cancer.net)
Despite surgical removal of the cancer, many patients with ovarian cancer will already have microscopic cancer cells, called micrometastases that have spread away from the ovary to other locations in the abdomen and distant parts of the body. (yourcancercare.com)
If the cancer involves only one ovary and the surgery shows no cancer beyond a single ovary, a unilateral salpingo-oophorectomy (removal of one ovary and fallopian tube) can be performed. (yourcancercare.com)
Outcomes after multiple lines of chemotherapy for platinum-resistant epithelial cancers of the ovary, peritoneum, and fallopian tube. (nih.gov)

Lonsurf (trifluridine/tipiracil) is a chemotherapy medication that has been approved by the Food and Drug Administration (FDA) in the USA, European Medical Agency (EMA) in the European Union, and Therapeutic Goods Administration (TGA) in Australia for the treatment of metastatic colorectal cancer in previously treated patients. (rhghspace.com)
Onivyde (irinotecan hydrochloride trihydrate) is a chemotherapy drug used to treat metastatic adenocarcinoma of the pancreas that has worsened despite previous cancer treatment containing gemcitabine. (rhghspace.com)
Food and Drug Administration approved the combination of nivolumab (OPDIVO, Bristol-Myers Squibb Co.) plus ipilimumab (YERVOY, Bristol-Myers Squibb Co.) and 2 cycles of platinum-doublet chemotherapy as first-line treatment for patients with metastatic or recurrent non-small cell lung cancer (NSCLC), with no epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) genomic tumor aberrations. (blogspot.com)
Food and Drug Administration approved brigatinib (ALUNBRIG, ARIAD Pharmaceuticals Inc.) for adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test. (blogspot.com)
Food and Drug Administration approved olaparib (LYNPARZA, AstraZeneca Pharmaceuticals, LP) for adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC), who have progressed following prior treatment with enzalutamide or abiraterone. (blogspot.com)
Food and Drug Administration granted accelerated approval to rucaparib (RUBRACA, Clovis Oncology, Inc.) for patients with deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy. (blogspot.com)
Adult and pediatric patients ≥12 years of age with advanced or metastatic RET fusion-positive thyroid cancer who require systemic therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate). (blogspot.com)
For patients with metastatic ovarian cancer (cancer detected outside the abdomen), surgery may be beneficial for relief of symptoms and to improve duration of survival. (yourcancercare.com)
New onset of symptoms or a rising CEA warrants investigation with chest and abdominal CT to look for recurrent or metastatic disease that may be amenable to therapy. (health.am)
For patients with a rising CEA with unrevealing CT imaging, a PET scan is more sensitive for the detection of occult metastatic disease. (health.am)
Participant must have histologically confirmed, locally advanced (i.e., not amenable to curative surgery and/or radiation therapy) or metastatic cancer that has progressed during or after at least 1 prior therapeutic regimen. (ucsd.edu)
We describe a case of a 55-year-old woman with a rare metastatic micropapillary low-grade serous ovarian cancer who had been heavily pretreated. (sciencerepository.org)
This therapy showed a good and lasting response representing a new opportunity for therapy in heavily pretreated metastatic micropapillary low-grade serous ovarian cancer. (sciencerepository.org)

[ 1 , 2 ] Currently, both early-stage and advanced-stage fallopian tube cancers are treated in much the same way as ovarian cancers-that is, with surgery followed by chemotherapy. (medscape.com)
In fact, most patients with stage I disease are treated with adjuvant chemotherapy because of the luminal structure of the organ and the risk of shedding cells out of the tubes and into the abdominal cavity. (medscape.com)
Accordingly, the chemotherapy used to treat primary fallopian tube cancers is based on the standard management of ovarian cancers. (medscape.com)
Consensus-based guidelines from the National Comprehensive Cancer Network (NCCN) suggest administering three to six cycles of chemotherapy for stage IA-IC disease and six to eight cycles for stage II-IV disease. (medscape.com)
As in ovarian cancer, the use of intraperitoneal (IP) chemotherapy must be considered the current standard treatment option in patients with stage II-IV disease. (medscape.com)
Patients who have undergone optimal tumor debulking should be offered IP chemotherapy. (medscape.com)
These patients have been re-treated with platinum-based chemotherapy. (medscape.com)
Treatment of epithelial ovarian cancer is based on the combination of cytoreductive surgery and combination chemotherapy using taxane and platinum. (biomedcentral.com)
Over the past three decades, surgical tumor debulking, followed by platinum-based chemotherapy is the standard treatment for advanced ovarian cancer. (biomedcentral.com)
Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
Treatment recommendations are currently based on case reports and small series describing combinations of surgery, chemotherapy and radiotherapy providing the best patient outcomes. (biomedcentral.com)
The patient was initially treated with surgery, chemotherapy and radiotherapy and developed disease progression. (biomedcentral.com)
Overall, better outcomes are reported in those patients whose initial treatment includes a combination of surgery, chemotherapy and radiation where appropriate [ 5 , 6 ]. (biomedcentral.com)
all patients with this histologic subtype should be considered for chemotherapy. (medscape.com)
All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)
Niraparib as maintenance therapy for treating recurrent or primary-advanced endometrial cancer after chemotherapy in combination with dostarlimab. (nihr.ac.uk)
In most cases, modern treatment of ovarian cancer includes radical cytoreductive surgery, followed by platinum- and paclitaxel-based systemic chemotherapy ( 5 - 7 ). (spandidos-publications.com)
After receiving a 6 course first line chemotherapy and 8 course maintenance therapy, the patient suffered acute abdominal pain , so surgery was performed. (symptoma.com)
Additional systemic treatment using chemotherapy or precision cancer medicines are required to treat micrometastatic cancer. (yourcancercare.com)
By administering chemotherapy first, micrometastatic cancer cells may be more easily destroyed and chemotherapy may reduce the amount of cancer, thereby allowing for more complete surgical removal of the cancer. (yourcancercare.com)
Advances in chemotherapy for colorectal cancer. (health.am)
Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
Avelumab alone or in combination with chemotherapy versus chemotherapy alone in platinum-resistant or platinum-refractory ovarian cancer (JAVELIN Ovarian 200): an open-label, three-arm, randomised, phase 3 study. (nih.gov)
It is not yet known whether combination chemotherapy is more effective when given with or without bevacizumab after surgery in treating patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer. (ucsf.edu)
To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases the duration of overall survival in patients with recurrent platinum sensitive epithelial ovarian cancer , peritoneal primary or fallopian tube cancer. (ucsf.edu)
To determine if surgical secondary cytoreduction in addition to adjuvant chemotherapy increases quality of life (QOL) in patients with recurrent platinum-sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer, as measured by the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) trial outcome index and Rand Short Form (SF)-36 physical functioning scale. (ucsf.edu)

Gastroesophageal junction adenocarcinoma, a form of cancer that is located in the region where the esophagus joins the stomach, is also rare, but equally lethal. (southcarolinablues.com)
Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)
Загальні джерела літератури Endometrial cancer is usually endometrioid adenocarcinoma. (msdmanuals.com)

On MRI, endometriotic cysts with enhanced mural nodules are a hallmark of ovarian cancer, but they may also be a feature of benign neoplasms and even inflammatory diseases. (medscape.com)
These neoplasms can be benign or malignant. (lookformedical.com)
Some doctors also recommend fallopian tube removal when a person is undergoing surgery for a benign disease and does not want to get pregnant in the future. (cancer.net)

The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along with fallopian tube and peritoneal cancers because of shared clinical features. (merckmanuals.com)
The most common histology-high-grade serous epithelial ovarian cancer-is considered as a single clinical entity along. (merckmanuals.com)

EOC can include cells of origin from both the ovarian surface epithelium and the fallopian tube ( 2 ). (spandidos-publications.com)
Indeed, it has been postulated that the possible mechanisms by which repetitive ovulation could influence the development of ovarian carcinomas include an increased formation of inclusion cysts, repeated bathing of the surface epithelium by an estrogen-rich follicular fluid, excessive production of growth factors or cytokines, and an aberration of the repetitive repair process that follows the trauma to the surface epithelium as a consequence of ovulation. (biomedcentral.com)

Primary peritoneal cancer often spreads to the ovaries. (medlineplus.gov)
It appears that the vast majority of what seem to be primary epithelial ovarian and primary peritoneal carcinomas is, in fact, secondary from the fimbria, the most distal part of the fallopian tube. (biomedcentral.com)
Niraparib in combination with dostarlimab is in clinical development for patients with recurrent or primary-advanced endometrial cancer. (nihr.ac.uk)
In addition to clinical manifestations of the primary malignancy, patients may complain of abdominal pain , swelling [4], bloating, and increase in abdominal girth (due to ascites ) [5]. (symptoma.com)
This is a phase I, open-label, non-randomized multicenter dose-escalation study with the primary objective to determine the maximally tolerated dose (MTD) of fostamatinib when administered with weekly paclitaxel in women with recurrent platinum -resistant ovarian, fallopian tube, or primary peritoneal cancer. (survivornet.com)
Fallopian tube and primary peritoneal cancers are treated in the same manner as epithelial ovarian cancers and are thus included in this study. (inclinicaltrials.com)
Recurrent, advanced, platinum resistant ovarian, fallopian tube, and primary peritoneal cancer and must have a histological diagnosis of a high-grade serous histology. (survivornet.com)
This randomized phase III trial studies carboplatin, paclitaxel and gemcitabine hydrochloride when given together with or without bevacizumab after surgery to see how well it works in treating patients with ovarian, epithelial, primary peritoneal, or fallopian tube cancer that has come back. (ucsf.edu)
A Phase III Randomized Controlled Clinical Trial of Carboplatin and Paclitaxel (or Gemcitabine) Alone or in Combination With Bevacizumab (NSC #704865) Followed by Bevacizumab and Secondary Cytoreductive Surgery in Platinum-Sensitive, Recurrent Ovarian, Peritoneal Primary and Fallopian Tube Cancer. (ucsf.edu)
To determine if the addition of bevacizumab to the second-line and maintenance phases of treatment increases the duration of overall survival relative to second-line paclitaxel and carboplatin alone in patients with recurrent platinum sensitive epithelial ovarian cancer, peritoneal primary or fallopian tube cancer. (ucsf.edu)

Rarely, peritoneal cancer can develop after ovaries and fallopian tubes have been removed. (cancer.net)

Epithelial ovarian cancer (EOC) is one of the leading cancers in women, with high-grade serous ovarian cancer (HGSOC) being the most common and lethal subtype of this disease. (bvsalud.org)

80% and 40-60%, respectively, after first-line treatment with carboplatin and paclitaxel, most patients will eventually relapse with a median progression-free survival of 18 months [ 2 ]. (biomedcentral.com)
Mutation testing by Caris molecular intelligence demonstrated a breast cancer 2 gene mutation and further treatment with carboplatin and veliparib achieved disease stabilisation. (biomedcentral.com)
The GOG 252 authors concluded that the toxicity and patient-reported outcomes support selection of the regimen consisting of IV carboplatin AUC 6 day 1, dose-dense paclitaxel 80 mg/m 2 IV once weekly, and bevacizumab 15 mg/kg IV day 1 given in 3-week cycles. (medscape.com)
This phase I study was conducted to determine the maximum tolerated dose and the recommended phase II dose of weekly administered Genexol-PM combined with carboplatin in patients with gynecologic cancer. (e-crt.org)
Weekly administered Genexol-PM with carboplatin demonstrated an acceptable safety profile in gynecologic cancer patients. (e-crt.org)
Paclitaxel and carboplatin (TC) is a standard treatment for various gynecologic cancers [ 1 - 3 ]. (e-crt.org)
In the phase III JGOG 3016 trial, dose-dense weekly paclitaxel (80 mg/m 2 ) plus 6 area under the curve (AUC) of carboplatin had a better median progression-free survival (PFS) compared with the tri-weekly conventional regimen in ovarian cancer patients (28.0 vs. 17.2 months) [ 9 , 10 ]. (e-crt.org)
To prospectively determine the incidence of carboplatin and paclitaxel hypersensitivity in these patients undergoing retreatment with both agents as first recurrence therapy. (ucsf.edu)

In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (lookformedical.com)
Mutations of this gene are associated with the formation of HEREDITARY BREAST AND OVARIAN CANCER SYNDROME. (lookformedical.com)
Mutations in this gene predispose humans to breast and ovarian cancer. (lookformedical.com)
Any neoplasms of the male breast. (lookformedical.com)
Ovarian metastasis is not a rare condition and occurs secondary to malignancies originating from the stomach, colon , breast, endometrium, fallopian tubes , or cervix. (symptoma.com)
Uptake, Results, and Outcomes of Germline Multiple-Gene Sequencing after Diagnosis of Breast Cancer. (ejgo.net)
8] Practice Bulletin No 182: Hereditary Breast and Ovarian Cancer Syndrome. (ejgo.net)
Mutations in the autosomal dominant BRCA gene are associated with a 50 to 85% lifetime risk of developing breast cancer. (merckmanuals.com)
More than ninety% of smokers have in females in the United States has already exceeded breast sequential epithelial changes within the respiratory tract within the most cancers as a reason for demise in ladies. (ehd.org)
The mammographic and sonographic findings of these lesions are also highly suspicious for breast cancer, so a biopsy is always essential for definitive diagnosis. (health.am)

In 1934, Joe Vincent Meigs in New York originally described tumor debulking surgery (cytoreductive surgery) for ovarian cancer under the premise of reducing macroscopic disease. (wikipedia.org)
This type of surgery, in which the goal is to remove the greatest volume of cancer cells possible, is also called "cytoreductive" surgery. (yourcancercare.com)

Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
The condition of a pattern of malignancies within a family, but not every individual's necessarily having the same neoplasm. (lookformedical.com)
Ovarian metastasis accounts for up to 30% of all ovarian malignancies. (symptoma.com)
Fallopian tube cancer is the least common of gynaecological malignancies. (annals.edu.sg)
His research program spans a range from basic studies in molecular cancer genetics and tumor immunology to translational clinical cancer research testing novel immunotherapeutic strategies and targeted compounds in vivo for the treatment of gynecologic malignancies. (yale.edu)
He is a member of the GOG Developmental Therapeutics Committee, a national Committee that reviews multi-site concepts/protocols to be implemented at nationwide level by the GOG funded by the NIH and he is Chairman for the entire GOG of multiple Phase II clinical studies testing novel biologic agents in patient harboring gynecologic malignancies. (yale.edu)

This phase II ComboMATCH treatment trial evaluates nilotinib with paclitaxel for the treatment of patients with solid cancers that are growing, spreading, or getting worse (progressive) and that have previously been treated with taxane therapies. (policylab.us)
Giving nilotinib with paclitaxel may be effective at treating patients with progressive solid cancers that have previously been treated with taxane therapies. (policylab.us)
at least 6 patients with receive fostamatinib plus paclitaxel at the MTD. (survivornet.com)
however, patients may not have previously received weekly paclitaxel in the recurrent setting. (survivornet.com)
The GOG0209 trial reported that TC is not inferior to the paclitaxel-doxorubicin-cisplatin regimen and had a more tolerable toxicity profile, which suggested that TC should be considered as a first-line regimen for advanced or recurrent endometrial cancer [ 5 ]. (e-crt.org)
Therefore, paclitaxel remains one of the most important anticancer drugs for gynecologic cancer. (e-crt.org)

Intraperitoneal hyperthermic chemoperfusion (HIPEC or IPHC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. (wikipedia.org)
Impaired Wound Healing: Withhold Cyramza prior to surgery and discontinue Cyramza if a patient develops wound healing complications. (southcarolinablues.com)
Surgery is the initial therapy for stage I-IV fallopian tube cancers. (medscape.com)
Only a small percentage of women with epithelial fallopian tube cancers are treated with surgery alone. (medscape.com)
Surgery is the initial modality of treatment for stage I-IVA epithelial ovarian cancer. (medscape.com)
However, only a small percentage of women with epithelial ovarian cancer can be treated with surgery alone. (medscape.com)
1 cm) stage III ovarian cancer after front-line surgery. (medscape.com)
The successful treatment of ovarian cancer requires the involvement and coordination of several different treatment approaches, including surgery, systemic therapy, and, in rare cases, radiation therapy. (yourcancercare.com)
Nearly all women with ovarian cancer will undergo surgery and systemic treatment. (yourcancercare.com)
The role of surgery in the initial management of ovarian cancer is to obtain a biopsy specimen of the cancer to confirm the diagnosis, determine the stage of cancer and to provide local treatment of the cancer in the pelvis and abdomen. (yourcancercare.com)
Patients with ovarian cancer are often initially treated with surgery aimed at debulking (decreasing the size of) the cancer. (yourcancercare.com)
After completion of this initial surgery, most patients are placed on a systemic treatment regimen. (yourcancercare.com)
For patients diagnosed with ovarian cancer during surgery, the first phase of treatment is surgical laparotomy or exploration of the abdomen. (yourcancercare.com)
Surgery to remove cancer in the abdomen may help relieve pain, prevent obstruction or blockage of the bowel, and improve a patient's nutritional status. (yourcancercare.com)
The typical surgery for ovarian cancer prevents women from future childbearing because the reproductive organs (ovaries and uterus) are removed. (yourcancercare.com)
This is because patients have undetectable microscopic cancer cells that have spread from the original site of cancer to distant locations in the body and were not removed by surgery. (yourcancercare.com)
The databases consisted of individual patients with EOC who underwent upfront surgery between January 1998 and December 2016 at seven gynecologic oncology departments in Turkey. (biomedcentral.com)
We included only the patients with optimal or maximal CRS in the upfront surgery. (biomedcentral.com)

Fallopian tube carcinomas were once believed to be rare. (medscape.com)
We report herein the newly described molecular abnormalities in epithelial ovarian cancers (carcinomas). (biomedcentral.com)
Our better understanding of the molecular basis of ovarian carcinomas represents the first step in the development of targeted therapies in the near future. (biomedcentral.com)
Ovarian carcinomas are characterized by a Müllerian morphology although the ovaries do not originate from the Müllerian ducts. (biomedcentral.com)
Serous carcinomas are thought to be derived from the fallopian tubes through foci of endosalpingiosis, which are inclusion cysts from the tubal epithelium at the ovarian and peritoneal surface. (biomedcentral.com)

Most are targeting perimenopausal or postmenopausal women or those with a family history of epithelial ovarian cancer. (medscape.com)
Ovarian cancer affects mainly perimenopausal and postmenopausal women. (merckmanuals.com)
Endometrial cancer affects mainly postmenopausal women. (msdmanuals.com)

A woman's lifetime risk of developing ovarian cancer is about 1 in 75. (medlineplus.gov)

Single-agent treatment is the preferred approach for platinum-resistant patients or intermediate platinum-sensitive patients with a short time to recurrence (6-12 months). (medscape.com)
Patients must have recurrent, platinum-resistant disease (defined as having relapsed within 6 months of last platinum-containing regimen) or be unable to receive further platinum therapy. (survivornet.com)
This study is intended for the patients who have been diagnosed with Epithelial Ovarian Cancer that either came back or did not improve after platinum treatments (platinum resistant). (survivornet.com)
Treatment Patterns and Health Outcomes in Platinum-Refractory or Platinum-Resistant Ovarian Cancer: A Retrospective Medical Record Review. (nih.gov)

Patients are randomized to 1 of 3 treatment arms. (knowcancer.com)
In most cases, this approach may only serve to delay diagnosis and treatment of ovarian cancer. (medscape.com)
4] In addition, older patients appear to receive less aggressive treatment than younger patients. (cancernetwork.com)
Part 2, to be published in next month's issue of ONCOLOGY , will detail diagnosis and treatment trials for recurrent disease. (cancernetwork.com)
Portrazza (necitumumab) is a medication approved for the treatment of advanced squamous non-small cell lung cancer. (rhghspace.com)
Rubraca (rucaparib) is a medication used to treat certain types of ovarian cancer, including advanced ovarian cancer that has relapsed or progressed despite previous treatment. (rhghspace.com)
Fine-needle aspiration (FNA) or percutaneous biopsy of an adnexal mass is not routinely recommended, as it may delay diagnosis and treatment of ovarian cancer. (medscape.com)
recurrent cancer means the cancer has come back after treatment. (nihr.ac.uk)
The histopathology of ovarian cancer is heterogeneous, and each subtype harbors specific genetic mutations that can be used for diagnostics and targeted treatment. (spandidos-publications.com)
Although great strides have been made in treating cancers, a significant number of patients still reach the point at which no curative treatment is. (annals.edu.sg)
Indications for single-agent therapy, preferred second-line therapy, subsequent therapy, relapsed or refractory therapy, pediatric and adult treatment, and limitations of use are all addressed within each section of specific cancer. (ibx.com)
for adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib. (blogspot.com)
Most patients with ovarian cancer will require systemic treatment as part of the overall treatment plan. (yourcancercare.com)
These extensive and time-consuming surgeries are best performed by a gynecologic oncologist, who is a surgeon specialized in the treatment of female pelvic cancers. (yourcancercare.com)
This allows the patient to bear children and still provides adequate treatment for the cancer. (yourcancercare.com)
Despite surgical removal of the cancer, the majority of patients with stage II-IV ovarian cancer will experience a recurrence if no additional systemic treatment is given. (yourcancercare.com)
For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load and the HCV therapy is not an excluded concurrent medication. (survivornet.com)
Six repeat 28-day cycles were planned for the treatment course depending on patient tolerance and response. (endometriosi.it)
Most patients (88.9%) with adverse events recovered without sequelae, and no treatment-related death occurred. (e-crt.org)
The TC regimen has been reported to elicit an overall response rate (ORR) of 68% to 70% as a first-line treatment in ovarian cancer [ 4 ]. (e-crt.org)
Antibody-based therapy has in recent years become an important treatment strategy for cancer. (justia.com)
The purpose of this study is to test the safety of using a new treatment called Integrated Circuit T (ICT) cells (AB-1015 cells) in patients with ovarian cancer . (survivornet.com)
After completion of study treatment, patients are followed with serial measurements of safety, tolerability and response. (survivornet.com)
However, a subgroup of patients presents a clinically aggressive course with disease progression despite receiving treatment. (rare-cancer.org)
Here, we describe the development of ABBV-011, a novel SEZ6-targeted, calicheamicin-based ADC for the treatment of small cell lung cancer (SCLC). (aacrjournals.org)
Ultimately, both the patient and partner must be in tune with the treatment modalities to optimize their overall satisfaction. (lecturio.com)
Platinum-free interval affects efficacy of following treatment for platinum-refractory or -resistant ovarian cancer. (nih.gov)
The current treatment of recurrent ovarian cancer. (nih.gov)
Clinical trials are studying cancer from a variety of angles, including prevention and treatment. (benaroyaresearch.org)

Mitomycin C and oxaliplatin are the most commonly used agent for colorectal cancer, while cisplatin is used in ovarian cancer. (wikipedia.org)
ASGE guidelines: colorectal cancer screening and surveillance. (health.am)
Colorectal cancer s found after a complete colonoscopy. (health.am)
Lieberman D. Screening for colorectal cancer in average-risk populations. (health.am)
Systematic therapy for colorectal cancer. (health.am)
The role of CT colography in colorectal cancer screening. (health.am)
Noninvasive testing for colorectal cancer: a review. (health.am)
Colonoscopy in colorectal-cancer screening for detection of advanced neoplasia. (health.am)

Evidence supports a benefit in certain cases of ovarian cancer. (wikipedia.org)

These findings suggest that these two different types of ovarian cancers develop along different molecular pathways. (biomedcentral.com)

Understanding of the molecular profile of rare tumours is key to improve therapeutic decision making and patient outcomes. (biomedcentral.com)
J. Donnez  Fertility preservation is a major challenge when therapeutic approaches of ovarian endometrioma are planned. (slideshare.net)
Therapeutic Implications of Germline Testing in Patients with Advanced Cancers. (ejgo.net)
Recently, therapeutic advances have been made in gynecologic cancer including olaparib in BRCA -mutated ovarian cancer and pembrolizumab in mismatch repair-deficient or microsatellite instability-high endometrial cancer [ 6 , 7 ]. (e-crt.org)
Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided. (justia.com)
However, a key challenge in developing candidate therapeutic antibodies for cancer is the identification of antigens suitable for antibody-based therapy. (justia.com)

About 29% to 35% of gastric cancer cases have regional spread to lymph nodes or metastasis to distant sites. (southcarolinablues.com)

Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: US Preventive Services Task Force Recommendation Statement. (ejgo.net)
Doubling of cancer antigen 125 (CA-125) level on 2 successive measurements may be considered as meeting the definition of disease progression b) Have received at least 2 lines of prior therapy including a platinum-based regimen if eligible and a poly-ADP ribose polymerase ( PARP ) inhibitor if BRCA 1/2 mutated. (survivornet.com)

Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (merckmanuals.com)

Simple ovarian cysts are not cancerous. (cancer.net)
The fundamental basis of antibody-based cancer therapy is the fact that cancerous tissues express an array of antigens that may be overexpressed, selectively expressed or mutated compared to normal, non-cancerous tissue. (justia.com)
This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
In the case of cancer, the immune system fails to recognize the cancerous cells and they can grow uncontrolled within the body. (benaroyaresearch.org)

Core needle biopsy may be useful in the diagnosis of recurrent lesions on follow-up. (health.am)

SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
Cervical cancer is a preventable disease that affects nearly half a million women worldwide. (annals.edu.sg)
An ethnographic study of cervical cancer among women in rural Kenya: is there a folk causal model? (bmj.com)

Large contrast-enhanced nodules on large endometriotic cysts in an elderly patient are more likely to indicate malignancy. (medscape.com)
Ovarian cancer is the most lethal gynecologic malignancy. (biomedcentral.com)
Ovarian cancer is the most common gynaecological malignancy with over 5000 new cases diagnosed every year in the UK and 22 000 in the. (annals.edu.sg)

Staging fallopian tube cancer involves the removal of both fallopian tubes and of the ovaries, uterus, cervix, infracolic omentum, and retroperitoneal lymph nodes, in addition to peritoneal washings and peritoneal biopsies. (medscape.com)
The objective of a cervical screening programme is to prevent invasive cancer of the cervix by detecting and treating pre-invasive disease of the cervix. (annals.edu.sg)

Currently, the National Cancer Institute (NCI) recommends that high-risk women should seek advice from their physician and consider having annual ultrasonographic examination and annual CA125 testing, and be considered for oophorectomy or participation in a clinical trial. (medscape.com)
[ 3 ] The National Cancer Institute (NCI) recommends that high-risk women seek advice from their physicians and consider having annual ultrasonographic examinations and annual CA125 testing, as well as consider oophorectomy or participation in a clinical trial. (medscape.com)

7] It has been hypothesized that higher levels of sun exposure in southern latitudes, resulting in increased vitamin D levels, may also be protective against the development of ovarian cancer. (cancernetwork.com)

Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions. (ejgo.net)
In the United States, ovarian cancer is the second most common gynecologic cancer (affecting approximately 1/70 women). (merckmanuals.com)
This open-label, phase I, dose-escalation study of weekly Genexol-PM included 18 patients with gynecologic cancer, who were equally divided into three cohorts of dose levels. (e-crt.org)
Dr. Santin has initiated and completed multiple investigator's initiated FDA approved clinical trials in gynecologic cancer patients using novel immunotherapeutic strategies developed and characterized in his own laboratory. (yale.edu)

In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time. (wikipedia.org)
Just as with ovarian cancer, some peritoneal cancers may begin in the fallopian tubes and spread from the end of the fallopian tube into the peritoneal cavity. (cancer.net)

FDCS was thought to be an indolent disease and in some patients with localized tumours, prognosis can be favourable with 2 year mortality only 3 % [ 4 ]. (biomedcentral.com)
For each stage, rectal cancers have a worse prognosis. (health.am)
Most patients with MOC are diagnosed at an early stage and therefore it confers a favorable prognosis [ 3 ]. (biomedcentral.com)
Although PASH can recur, patient prognosis is good. (health.am)

Endometrial cancer occurs when cancer cells form in the tissues of the endometrium - the lining of the uterus. (nihr.ac.uk)

In about 90 percent of cases, ovarian cancer occurs after age 40, and most cases occur after age 60. (medlineplus.gov)
Cancers occur when a buildup of mutations in critical genes-those that control cell growth and division or repair damaged DNA-allow cells to grow and divide uncontrollably to form a tumor. (medlineplus.gov)
Somatic mutations in the TP53 gene occur in almost half of all ovarian cancers. (medlineplus.gov)
For esophageal cancer, the NCI estimates 16,980 new cases and 15,590 deaths will occur in 2015. (southcarolinablues.com)
Occasionally, ovarian cancer will occur in a younger woman who wishes to maintain fertility. (yourcancercare.com)
endometrial cancer due to inherited mutations tends to occur at a younger age and is often diagnosed 10 to 20 years earlier than sporadic cancer. (msdmanuals.com)

We performed a multicenter, retrospective review to identify patients with stage III MOC at seven gynecologic oncology departments in Turkey. (biomedcentral.com)
He has been involved in the training of 50 post-doctoral fellows, including Gynecologic Oncology, Medical Oncology and Surgical Oncology Fellows, the majority of whom have gone on to academic careers in the U.S. and abroad in Gynecologic Oncology and cancer research. (yale.edu)
Dr. Santin is an active member of the Gynecologic Oncology Group (GOG) and the International Gynecological Cancer Society (IGCS), the two largest organizations of gynecologic oncologists in the world. (yale.edu)

This study is a Phase 1, open-label, multicenter, dose escalation study to assess preliminary efficacy for STRO-002 combined with bevacizumab in patients with advanced ovarian cancer that is refractory or has relapsed after standard available therapy. (inclinicaltrials.com)

Endometrioid adenocarcinomas account for about 75 to 80% of endometrial cancers. (msdmanuals.com)

These cancers are described as hereditary and are associated with inherited gene mutations. (medlineplus.gov)
Hereditary ovarian cancers tend to develop earlier in life than non-inherited (sporadic) cases. (medlineplus.gov)
In hereditary ovarian cancer, the associated genetic changes are passed down within a family. (medlineplus.gov)

The fallopian tubes are small ducts that connect the ovaries to the uterus. (cancer.net)
Typically, the female reproductive system has 2 fallopian tubes, with 1 located on each side of the uterus. (cancer.net)
The frontal section shows the fallopian tubes, 2 small ducts that link the 2 ovaries (1 on each side) to the hollow, pear-shaped uterus. (cancer.net)

Symptoms independently associated with the presence of ovarian cancer include pelvic and abdominal pain, increased abdominal size and bloating, and difficulty eating or feeling full. (medscape.com)
Patients with more advanced disease may present with ovarian or pelvic mass, ascites, pleural effusion, or abdominal mass or bowel obstruction. (medscape.com)

Cancer can also begin in epithelial cells that form the lining of the abdomen (the peritoneum). (medlineplus.gov)
Because cancers that begin in the ovaries, fallopian tubes, and peritoneum are so similar and spread easily from one of these structures to the others, they are often difficult to distinguish. (medlineplus.gov)
It is hypothesized that the epithelium covering the ovarian surface and the peritoneum retains the potential for Müllerian differentiation given the proximity to the coelomic epithelium from which the Müllerian ducts are derived. (biomedcentral.com)
Because the surfaces of the ovaries, the lining of the fallopian tubes, and the covering cells of the peritoneum are made up of the same types of cells, most of these diseases look alike under a microscope. (cancer.net)

Current research suggests that the majority of these originate from the fallopian tubes. (medscape.com)

Somatic mutations in many other genes have also been found in ovarian cancer cells. (medlineplus.gov)

One of the most investigated and promising molecular targeted drugs in ovarian cancer is bevacizumab, a monoclonal antibody directed against VEGF. (biomedcentral.com)
A few recent studies demonstrated positive results of bevacizumab on progression-free survival in ovarian cancer patients, however, investigation of molecular targeting drugs in patients with ovarian cancer are still underway. (biomedcentral.com)
Colon Cancer Genetics Group, University of Edinburgh, School of Molecular and Clinical Medicine and MRC Human Genetics Unit, Western General Hospital, Edinburgh, U.K. (health.am)
However, recent results of targeted therapy and immunotherapy have limitations in that they can only be applied to limited groups of patients with specific molecular characteristics. (e-crt.org)
Our goal is to develop and use cutting edge systems biology approaches to elucidate molecular signatures of complex immune diseases, understand the mechanisms of disease, and identify the right therapy for the right patient. (benaroyaresearch.org)

The patient may feel an abdominal mass. (medscape.com)
Peritoneal washings -collection of abdominal fluid samples and removal of lymph nodes so that they can be examined under a microscope to determine whether they contain cancer. (yourcancercare.com)

A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment. (ejgo.net)

Anatomy9

Organisms1

Diseases36

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes10

Disciplines and Occupations1

Health Care1

Carcinoma21

Tumors37

Ovary11

Metastatic13

Chemotherapy26

Adenocarcinoma3

Benign3

Serous epithelial ovarian2

Surface epithelium2

Primary10

Ovaries and fallopian tubes1

High-grade serous ovarian cancer1

Carboplatin8

Breast10

Cytoreductive2

Malignancies6

Paclitaxel6

Surgery18

Carcinomas5

Postmenopausal women3

Risk of developing ova1

Platinum-resistant4

Treatment29

Colorectal cancer8

Cases of ovarian cancer1

Types of ovarian1

Therapeutic6

Metastasis1

BRCA2

Tumor markers5

Cancerous4

Lesions1

Cervical cancer3

Malignancy3

Cervix2

Clinical Trial2

Development of ovarian1

Gynecologic Cancer4

Peritoneal cavity2

Prognosis4

Endometrium1

Occur6

ONCOLOGY3

Refractory1

Endometrial cancers1

Hereditary3

Uterus3

Pelvic2

Peritoneum4

Originate1

Somatic1

Molecular5

Abdominal2

Indications1