Patients with recurrent or refractory medulloblastoma. Medical search. Frequent questions

Background: Brain tumors are the leading cause of cancer death for pediatric patients. (elsevierpure.com)
We report a phase I trial with the primary goal of evaluating the safety of sargramostim/pelareorep in pediatric patients with recurrent or refractory high-grade brain tumors and a secondary goal of characterizing immunologic responses. (elsevierpure.com)
Methods: The trial was open to pediatric patients with recurrent or refractory high-grade brain tumors (3 + 3 cohort design). (elsevierpure.com)
Conclusions: Sargramostim/pelareorep was administered to pediatric patients with recurrent or refractory high-grade brain tumors. (elsevierpure.com)
Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the most common pediatric brain malignancy. (biomedcentral.com)
As the most common malignant brain cancer in children, medulloblastoma (MB) accounts for 20% of CNS tumors and occurs most commonly in the pediatric population, particularly in those younger than 15 years of age [ 4 , 5 ]. (biomedcentral.com)
This phase II Pediatric MATCH trial studies how well ensartinib works in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with ALK or ROS1 genomic alterations that have come back (recurrent) or does not respond to treatment (refractory) and may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). (ucbraid.org)
This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). (ucbraid.org)
Medulloblastoma and primitive neuroectodermal tumor (PNET) account for approximately 15%, and 3% of pediatric malignant tumors of the central nervous system (CNS), respectively [ 1 ]. (e-apem.org)
This study will evaluate palbociclib in combination with chemotherapy (temozolomide and irinotecan) in children, adolescents and young adults with recurrent or refractory solid tumors. (cincinnatichildrens.org)
Our study found that medulloblastoma tumors fall into distinct clusters based solely on GPCR expression patterns. (biomedcentral.com)
Elucidating tumorigenic pathways is a secondary benefit to identifying differential GPCR expression patterns in medulloblastoma tumors. (biomedcentral.com)
Medulloblastoma is an embryonal tumor of the cerebellum that accounts for 20% of all pediatric brain tumors and is the most common cause of death from CNS malignancy in children [ 1 ]. (biomedcentral.com)
Historically, medulloblastoma tumors have been treated according to a morphology-based classification system that divides tumors into three principle histopathologic classes: classic, desmoplastic/nodular and large cell/anaplastic (LCA) [ 4 ]. (biomedcentral.com)
This is a Phase 1 study of central nervous system (CNS) locoregional adoptive therapy with autologous CD4 and CD8 T cells lentivirally transduced to express a HER2-specific chimeric antigen receptor (CAR) and EGFRt, delivered by an indwelling catheter in the tumor resection cavity or ventricular system in children and young adults with recurrent or refractory HER2-positive CNS tumors. (fredhutch.org)
Samples of adrenal tumors were collected from patients undergoing adrenalectomy at the Department of Urology, the First Hospital of China Medical University. (cancerindex.org)
This phase I clinical trial measures the amount and effect of lidocaine injected into patients with glioblastoma while they are undergoing surgical removal of their brain tumors. (braintumor.org)
Is CAR T-cell therapy safe to give to children and young adults with relapsed or refractory CNS tumors (tumors of the brain or spinal cord)? (seattlechildrens.org)
STRIvE-01 is a phase 1 trial testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory solid tumors that express the protein EGFR or B7H3. (seattlechildrens.org)
ENLIGHTen-01 is a phase 1 clinical trial testing CAR T cells administered with UB-TT170, a small molecule fluorescein tag that targets folate receptors to mark tumors for clearance by CAR T cells, that is open to teens and young adults with recurrent or refractory osteosarcoma. (seattlechildrens.org)
The common embryonal brain tumor medulloblastoma and the rare atypical rhabdoid teratoid tumor are well-defined entities in terms of their histopathological features, immunophenotype, and genetic profiles, as are other brain tumors occurring in this age range, including choroid plexus tumors and infant gliomas, and they are discussed in separate articles. (medlink.com)
Safety, antitumor activity, and biomarker analysis in a phase Ⅰ trial of the once-daily wee1 inhibitor adavosertib (AZD1775) in patients with advanced solid tumors [J]. Clin Cancer Res, 2021, 27(14): 3834-3844. (magtechjournal.com)
Diagnosis of hereditary tumors may also change the cancer treatment strategy for the diagnosed patient. (ejgo.net)

Results: Six patients participated, including three glioblastoma, two diffuse intrinsic pontine glioma, and one medulloblastoma. (elsevierpure.com)
This phase III trial investigates the best dose of vinblastine in combination with selumetinib and the benefit of adding vinblastine to selumetinib compared to selumetinib alone in treating children and young adults with a low-grade glioma that has come back after prior treatment (recurrent) or does not respond to therapy (progressive). (braintumor.org)
This phase II trial studies the side effects of solriamfetol in improving sleep in patients with grade II-IV glioma. (braintumor.org)
Dr. Lim's bibliography contains well over 200 articles on topics such as immunotherapy for glioblastoma, long-term survival of glioma patients treated with stereotactic radiation, and treatment of neuropathic pain. (stanfordhealthcare.org)

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma. (ucbraid.org)
This phase II trial studies how well irinotecan hydrochloride, temozolomide, and dinutuximab work with or without eflornithine in treating patients with neuroblastoma that has come back (relapsed) or that isn't responding to treatment (refractory). (ucbraid.org)

As a service to physicians, researchers, patients, and families, the registry has compiled a list of selected peer-reviewed references related to dipg. (dipgregistry.org)
The FDA has approved an expansion cohort to allow more patients to enroll on this trial and spots remain for children with DIPG. (seattlechildrens.org)

We investigated the clinical characteristics of patients who developed thyroid dysfunction and evaluated the risk factors for hypothyroidism following radiotherapy and chemotherapy in pediatric patients with medulloblastoma or primitive neuroectodermal tumor (PNET). (e-apem.org)
PURPOSE: This is a 2-part study of pembrolizumab (MK-3475) in pediatric participants who have either advanced melanoma or a programmed cell death ligand 1 (PD-L1)-positive advanced, relapsed or refractory solid tumor or lymphoma. (cincinnatichildrens.org)
Medulloblastoma is the most common malignant brain tumor in children. (biomedcentral.com)
Identification of tumor subgroup using molecular classification is set to become an important component of medulloblastoma diagnosis and staging, and will likely guide therapeutic options. (biomedcentral.com)
Further, two of the tumor clusters correspond with high fidelity to the WNT and SHH subgroups of medulloblastoma. (biomedcentral.com)
A child or young adult with a refractory or recurrent CNS tumor will have their tumor tested for HER2 expression by immunohistochemistry (IHC) at their home institution or at Seattle Children's Hospital. (fredhutch.org)
If the tumor is HER2 positive and the patient meets all other eligibility criteria, including having a CNS catheter placed into the tumor resection cavity or into their ventricular system, and meets none of the exclusion criteria, then they can be apheresed, meaning T cells will be collected. (fredhutch.org)
The other hypothesis is that HER-specific CAR T cells safely can be administered through an indwelling CNS catheter to allow the T cells to directly interact with the tumor cells for each patient enrolled on the study safely can be delivered directly into the brain via indwelling catheter. (fredhutch.org)
part 2 will enroll patients requiring a biopsy in order to assess BXQ-350 concentrations in the biopsied tumor. (braintumor.org)
Medulloblastoma is the most common embryonal brain tumor, whereas other embryonal tumor types are considered "rare" and typically affect infants and very young children. (medlink.com)
Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness. (nih.gov)
Li L, Patel M, Nguyen HS, Doan N, Sharma A, Maiman D. Primary atypical teratoid/rhabdoid tumor of the spine in an adult patient. (surgicalneurologyint.com)
Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive neoplasm of the central nervous system that generally arises intracranially in patients under 2 years of age. (surgicalneurologyint.com)
While tumor imaging and radiotherapy strategies are crucial for tumor identification and treatment, the presence of metastasis and radiation resistance has reduced the efficacy of treatment in cancer patients. (biomedcentral.com)
CNSide can detect and quantify tumor cells in the CSF from patients with Breast Cancer or NSCLC having a suspicious or confirmed LM. (stanford.edu)
We are studying components of blood, tumor tissue, normal tissue, and other fluids, such as urine, cerebrospinal fluid, abdominal or chest fluid in patients with cancer. (stanford.edu)
During his time at Johns Hopkins, Dr. Lim built one of the largest brain tumor and trigeminal neuralgia practices and utilized the most advanced surgical technologies and techniques for his patients. (stanfordhealthcare.org)
The tumor testing (ie, immunohistochemistry, MSI, germline testing, and BRAF mutation testing), screening, and prophylactic surgery all help to reduce the risk of death in patients with HNPCC or Lynch syndrome. (medscape.com)

Temozolomide capsules are indicated for the treatment of adult patients with newly diagnosed glioblastoma concomitantly with radiotherapy and then as maintenance treatment. (nih.gov)
Temozolomide capsules are indicated for the treatment of adult patients with refractory anaplastic astrocytoma who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine. (nih.gov)
To test the effectiveness and safety of Optune® given concomitantly with radiation therapy (RT) and temozolomide (TMZ) in newly diagnosed GBM patients, compared to radiation therapy and temozolomide alone. (stanford.edu)

Refractory anaplastic astrocytoma who have experienced disease progression on a drug regimen containing nitrosourea and procarbazine. (nih.gov)
The most common Grade 3 to 4 hematologic laboratory abnormalities (≥ 10% incidence) in patients with anaplastic astrocytoma are: decreased lymphocytes, decreased platelets, decreased neutrophils, and decreased leukocytes. (nih.gov)

The aim of this systematic review will be to investigate the efficacy and safety of salvage therapies for the management of children with progressive, treatment-refractory, or recurrent MB. (biomedcentral.com)
TINT: A phase II study of trametinib in paediatric, adolescent and young adult patients with Neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas. (anzchog.org)

It was under development for the treatment of relapsed or refractory multiple myeloma, glioblastoma multiforme, blood cancer, metastatic non-small cell lung cancer and malignant pleural mesothelioma. (pharmaceutical-technology.com)

All patients progressed on therapy after a median of 32.5 days and died a median of 108 days after recruitment. (elsevierpure.com)
x_tab][x_tab active="false"]Aristizabal P, Burns L, Rivera-Gomez R, Levy ML, Roberts W, Crawford JR. Medulloblastoma With Extensive Nodularity: Tailored Therapy in a Low-resource Setting. (beatcc.org)
In additional analyses, we will investigate the role of re-irradiation and mono- vs. poly-therapy in recurrent disease, and whether molecular subgrouping of MB influences salvage therapy. (biomedcentral.com)
Since thyrotoxic and hypothyroid patients following head and neck irradiation therapy were firstly reported in the 1920s, and in the 1960s, respectively [ 4 ], thyroid dysfunction after radiotherapy has been reported in several studies [ 5 - 7 ]. (e-apem.org)
We hypothesized that analysis of GPCR expression would identify clear subsets of medulloblastoma and suggest distinct GPCRs that might serve as molecular targets for both imaging and therapy. (biomedcentral.com)
These patients may be eligible for therapy deintensification or early pursuit of novel treatments/approaches that are desperately needed. (stanfordchildrens.org)
All patients will receive BXQ-350 by intravenous (IV) infusion and radiation therapy. (braintumor.org)
The PLAT trials are phase 1 and 2 clinical trials testing CAR T-cell therapy in children, teens and young adults with relapsed or refractory acute leukemia or lymphoma. (seattlechildrens.org)
An oncolytic therapy delivered within the urinary bladder in combination with pembrolizumab has yielded high complete response rates in patients with bacillus Calmette-Guérin (BCG)-unresponsive bladder cancer, according to data presented by Roger Li, MD , lead study investigator and urologic. (ascopost.com)
Breast cancer is a heterogeneous disease associated with different patient prognosis and responses to therapy. (biomedcentral.com)
Indications for single-agent therapy, preferred second-line therapy, subsequent therapy, relapsed or refractory therapy, pediatric and adult treatment, and limitations of use are all addressed within each section of specific cancer. (ibx.com)

Alveolar rhabdomyosarcoma has superior response rates to vinorelbine compared to embryonal rhabdomyosarcoma in patients with relapsed/refractory disease: A meta-analysis. (nih.gov)

The medical records of 66 patients (42 males) treated for medulloblastoma (n=56) or PNET (n=10) in childhood between January 2000 and December 2014 at Seoul National University Children's Hospital were retrospectively reviewed. (e-apem.org)
Projects such as the Treehouse Childhood Cancer Initiative and St. Jude Children's Research Hospital's sequencing of more than 10,000 whole genomes from pediatric cancer patients and survivors are giving researchers and clinicians a better idea of what drives pediatric cancers. (genomeweb.com)
Over the past decade Dr. Parsons has served as the principal investigator for seminal studies evaluating the use of clinical genomic testing for childhood cancer patients as part of the NHGRI Clinical Sequencing Evidence-Generating Research (CSER) program. (bcm.edu)
Parsons DW, Li M, Zhang X, et al " The genetic landscape of the childhood cancer medulloblastoma . (bcm.edu)
The active clinical trials offered through COG and available at Hasbro Children's Hospital include front-line treatment for many types of childhood cancers, and trials for patients with relapsed cancer involving new and emerging treatments, including immunotherapy. (lifespan.org)

Vyriad conducts investigator sponsored trials targeted against myeloma, endometrial cancer, multiple myeloma, T cell lymphoma medulloblastoma, and others. (pharmaceutical-technology.com)
In the phase I/II MonumenTAL-1 trial, the novel bispecific antibody talquetamab produced responses in more than 70% of heavily pretreated patients with multiple myeloma. (ascopost.com)

Actuate 1902: A Phase 1 Study of 9-ING-41, a Glycogen Synthase Kinase 3 Beta (GSK3β) Inhibitor, as a Single Agent or with Irinotecan in Pediatric Patients with Refractory Malignancies. (lifespan.org)

Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least two or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)

He has a particular interest in the development and evaluation of molecular targeted therapies and has a number of leadership roles in this area including serving as the Children's Oncology Group (COG) study chair for the ongoing NCI-COG Pediatric MATCH trial, the first nationwide precision oncology trial for children and young adults with treatment refractory cancers. (bcm.edu)
Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
Therapeutic Implications of Germline Testing in Patients with Advanced Cancers. (ejgo.net)

This early phase I trial tests the use of a radioactive tracer (a drug that is visible during an imaging test) known as 18F-FMAU, for imaging with positron emission tomography/computed tomography (PET/CT) in patients with brain cancer or cancer that has spread to the brain (brain metastases). (braintumor.org)
This phase I trial investigates the side effects and effectiveness of chemotherapy followed by a donor (allogeneic) stem cell transplant when given to patients with high-grade brain cancer. (braintumor.org)
She also has completed a Neurotrauma fellowship at UCSF and San Francisco General Hospital with Geoff Manley, MD, PhD where she received specialized training in caring for patients after traumatic brain and spinal cord injuries. (stanford.edu)
She specifically focuses on understanding the association between socioeconomic and demographic characteristics and patient outcomes following traumatic brain injury. (stanford.edu)

She presented a case of a patient whose oncologist submitted him for participation in her team's sequencing protocol after he'd had what appeared to be a second recurrence of medulloblastoma. (genomeweb.com)
We aimed to assess the patterns of local recurrence (LR) in patients with STS treated with surgery with or without RT.We performed a retrospective analysis of adults with STSs evaluated at our institution between 2007-2021. (stanfordchildrens.org)
Furthermore, these three genes predicted overall survival and recurrence‑free survival in patients with ACC from the TCGA cohort. (cancerindex.org)

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (policylab.us)

During residency, she was awarded the Exceptional Physician Award from UCSF Medical Center and the Howard Nafzigger Award from the UCSF Department of Neurological Surgery for outstanding patient care. (stanford.edu)
MV-NIS, a modified measles virus, is among the oncolytic virus therapies with an ongoing clinical trial for medulloblastoma at UCSF. (ucsf.edu)

Provide Pneumocystis pneumonia (PCP) prophylaxis during concomitant phase and continue in patients who develop lymphopenia until resolution to Grade 1 or less. (nih.gov)
This phase I/II trial studies the side effects and best dose of Visudyne (liposomal verteporfin) to see how well it treats patients with high-grade EGFR-mutated glioblastoma that has come back (recurrent). (braintumor.org)
This phase I trial is studying the safety and effectiveness of nivolumab in combination with ipilimumab and surgery when used in the treatment of recurrent glioblastoma. (braintumor.org)
During the neutropenic phase (2-4 wk) the patient essentially has no effective immune system. (medscape.com)
Adavosertib plus gemcitabine for platinum-resistant or platinum-refractory recurrent ovarian cancer: a double-blind, randomised, placebo-controlled, phase 2 trial [J]. Lancet, 2021, 397(10271): 281-292. (magtechjournal.com)

Therefore, a systematic review of the literature regarding treatment strategies employed in recurrent pediatric MB will evaluate previous salvage therapies in order to guide future clinical trials. (biomedcentral.com)
Studies examining the survival and toxicity of therapies administered to treatment-refractory pediatric MB patients will be included. (biomedcentral.com)
Therefore, any targeted treatment regimen identified to be effective on primary MB samples is poised to fail in recurrent lesions. (biomedcentral.com)
This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (policylab.us)
Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (policylab.us)
Kung's group uses the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay - a hybridization capture-based NGS assay for targeted deep sequencing of all exons and selected introns of nearly 500 cancer genes - to sequence pediatric cancer patients that come to the center for treatment. (genomeweb.com)
A challenging patient population with advanced head and neck cancer may have a new treatment option, according to data presented during the 2022 Society for Immunotherapy of Cancer (SITC) Annual Meeting. (ascopost.com)
It is also used for long-term maintenance or prophylaxis, for example 200 mg-400 mg daily for HIV-infected patients, 400 mg daily for patients suffering from chronic pulmonary aspergillosis, or 100 mg per day for more than one year for the treatment of paracoccidioidomycosis [ 1 ]. (ecancer.org)
Through these national and regional groups, we have novel therapies and new treatment protocols available for virtually every pediatric cancer patient, as well as for children dealing with chronic hematologic diseases or the long-term consequences of cancer treatment. (lifespan.org)
Through our collaborative work and membership in the consortium we remain at the forefront of treatment for pediatric ALL and are able to offer our newly diagnosed ALL patients the most current clinical trials and therapies for this disease. (lifespan.org)

Despite best current therapies, patients with recurrent MB experience have an alarmingly high mortality rate and often have limited therapeutic options beyond inadequate chemotherapy or experimental clinical trials. (biomedcentral.com)
By reviewing the efficacy and toxicity of MB salvage therapies, this study will identify effective therapeutic strategies administered to recurrent MB patients and can inform future clinical trials aimed to improve patient survivorship and quality of life. (biomedcentral.com)
This has led to clinical trials using RAS-MAPK pathway targeted agents such as MEK inhibitors and BRAF V600E inhibitors for patients with molecular evidence of BRAF alterations. (oncologyradiotherapy.com)
My research concentrates on clinical trials for patients with late-stage central nervous system cancer. (stanford.edu)
Several ongoing clinical trials are underway to evaluate immunotherapies for both adult and pediatric patients. (ucsf.edu)
Rishi Lulla, MD, MS and Bradley DeNardo, MD offer world class, research-driven medicine and clinical trials, delivered to patients diagnosed with pediatric cancer and blood disorders. (lifespan.org)

Three-quarters of patients with pediatric medulloblastoma or PNET showed thyroid dysfunction, and over half had permanent thyroid dysfunction. (e-apem.org)
Thus, frequent monitoring of thyroid function is mandatory in all patients treated for medulloblastoma or PNET, especially, in very young patients and/or high-risk patients recommended for HDCT/ASCR. (e-apem.org)
Since survival rates markedly increased over the last 4 decades, leading to 70%-85% of cure rate in pediatric patients with medulloblastoma or PNET [ 3 ], regular monitoring of long-term complications related to radiotherapy and chemotherapy is needed to improve quality of life. (e-apem.org)
We aimed to investigate clinical characteristics of pediatric patients with medulloblastoma or PNET who developed thyroid dysfunction. (e-apem.org)
We also evaluated risk factors for thyroid dysfunction following radiotherapy and chemotherapy in pediatric medulloblastoma or PNET. (e-apem.org)

Refractory alveolar rhabdomyosarcoma in an 11-year-old male. (nih.gov)

Only few studies have focused on palliative radiotherapy used for patients who weren't suitable for resection by su. (biomedcentral.com)

Investigation of clinically tested therapies for children with recurrent MB has significant implications for clinical practice. (biomedcentral.com)

This systematic review will provide an overview of the current literature regarding salvage therapies for relapsed MB patients. (biomedcentral.com)
Although applying multi-modal therapies (radiation, chemotherapy, and surgery) has increased 5-year survival amongst standard-risk MB patients, overall survival (OS) rates seem to have plateaued. (biomedcentral.com)
These new therapies are promising and many pLGG that were refractory to traditional chemotherapy have had significant responses [ 11 , 12 ]. (oncologyradiotherapy.com)
We believe that offering cutting-edge medical therapies to patients close to home is of utmost importance. (lifespan.org)

Researchers are putting this knowledge to use by repurposing drugs that were originally developed for adult patients and giving them to pediatric patients. (genomeweb.com)
Primary spinal AT/RT in the adult patient is rare. (surgicalneurologyint.com)
5 9 ] Primary spinal AT/RT, especially within an adult patient, is rare. (surgicalneurologyint.com)

One patient experienced a dose limiting toxicity of persistent hyponatremia. (elsevierpure.com)

Methods: This prospective study included fresh stool samples collected from patients with gastroenteritis between August 2018 and March 2020. (bvsalud.org)
Age 10years, alveolar histology, FOXO1 fusion presence, unfavorable primary location, higher Oberlin score, and lack of radiation were identified as poor prognostic/predictive characteristics.This study represents the largest analysis of RMS metastatic to bone marrow, defining the poor prognostic outcome for these patients. (stanfordchildrens.org)
Information gained from this study may help researchers come up with new treatments to help patients with glioblastomas in the future. (braintumor.org)
The study began in November 2019 and is currently recruiting patients. (seattlechildrens.org)
The study began in April 2023 and is currently enrolling patients. (seattlechildrens.org)
Researchers use many other factors to decide whether a patient can take part in a study (inclusion criteria) or cannot take part (exclusion criteria). (seattlechildrens.org)
A pilot study provides a signal that the novel HER2 antibody-drug conjugate fam-trastuzumab deruxtecan-nxki (T-DXd), is active in the neoadjuvant setting in patients with HER2-low breast cancer. (ascopost.com)
Patient-Reported Outcomes Over 24 Months in Pediatric CKD: Findings From the MyKidneyHealth Cohort Study. (childrensmercy.org)
Although potential benefits of metronomic chemotherapy and alisertib have been reported, the patient in this study did not favorably respond to these modalities. (surgicalneurologyint.com)
The FORESEE Study is a multi-center, prospective clinical trial enrolling patients with Breast or Non-Small Cell Lung Cancer (NSCLC) who have suspicious or confirmed Leptomeningeal Metastases (LM). (stanford.edu)

An increase in cancer cell invasion and microvascular density is associated with a poorer prognosis for patients with endometrial cancer. (biomedcentral.com)

We advanced to a point where we could do the therapeutic experiment in the patient. (genomeweb.com)

Correlative assays revealed transient but consistent changes in immune cells across patients. (elsevierpure.com)
Hematopoietic stem cell transplantation (HSCT) involves the intravenous infusion of hematopoietic stem cells in order to reestablish blood cell production in patients whose bone marrow or immune system is damaged or defective. (medscape.com)

There are limited studies examining the outcomes specific to patients with RMS metastatic to bone marrow despite an incidence of 6% at diagnosis. (stanfordchildrens.org)
I collaborate with Stanford scientists to detect this disease earlier, and with our breast and lung oncologists to improve outcomes for patients. (stanford.edu)

The combination of capivasertib, an AKT pathway inhibitor, plus fulvestrant, an estrogen receptor antagonist, significantly improved progression-free survival compared with fulvestrant alone in patients with hormone receptor-positive, HER2-negative advanced breast cancer, according to results of. (ascopost.com)

Immunocompromised patients are often treated prophylactically with triazole anti-fungal drugs, including ITZ, particularly if there is a risk of aspergillosis . (ecancer.org)

Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (policylab.us)

Anatomy4

Organisms1

Diseases12

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes6

Health Care1

Tumors23

Glioma4

Neuroblastoma2

DIPG2

Tumor18

Temozolomide3

Astrocytoma2

Progressive2

Glioblastoma multiforme1

Therapy11

Embryonal1

Childhood5

Multiple myeloma2

Malignancies1

Atypical1

Cancers3

Brain4

Recurrence3

Lymphoma1

UCSF2

Phase5

Treatment10

Clinical trials6

PNET5

Rhabdomyosarcoma1

Radiotherapy1

Children1

Therapies4

Adult3

Persistent1

Study10

Endometrial cancer1

Therapeutic1

Immune2

Outcomes2

Receptor1

Drugs1

Combination1