Patients with ovarian. Medical search. Frequent questions

The effectiveness of the MIS/AAV9 construct was tested in mice implanted with ovarian cancer cells. (scienceblog.com)

Patients with low-grade serous ovarian carcinoma may experience a high symptom burden. (primeinc.org)
Described as a "milestone in the development of personalized treatment of recurrent ovarian carcinoma," PARP inhibitors function by impeding DNA repair. (ahdbonline.com)
High-grade serous ovarian carcinoma, constituting 70-80% of ovarian tumors, is particularly aggressive and frequently resistant to chemotherapy. (technologynetworks.com)
Approximately 50-75% of patients with serous ovarian carcinoma (SOC) experience recurrence within 18 months after first-line treatment. (oncotarget.com)
This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uclahealth.org)
Biochemical recurrence (eg, CA-125 in ovarian carcinoma) only is not considered as disease progression. (uclahealth.org)
A total of 320 patients aged ≥ 70 years with primary, advanced-stage ovarian carcinoma will be included. (utwente.nl)

In their report receiving online publication in PNAS Early Edition, a research team from Harvard-affiliated Massachusetts General Hospital (MGH) describes how a single injection of a modified version of Mullerian inhibiting substance (MIS), a protein critical to sexual development, suppressed the growth of chemotherapy-resistant ovarian tumors in a mouse model. (scienceblog.com)
While not all the tested tumors - grown from cells grafted from patient tumors - were sensitive to this treatment, the investigators also outlined a noninvasive way of screening cancer cells in vitro for treatment responsiveness. (scienceblog.com)
The potential of MIS to treat ovarian cancer and other reproductive tumors has been studied for many years by Patricia Donahoe , director of the MGH Pediatric Surgical Research Laboratories and senior author of the study. (scienceblog.com)
In a more clinically relevant experiment, applying the therapy to mice in which tumors already had been induced by implanting cancer cells from five different patients significantly inhibited further growth of tumors generated from the cells of three of the five patients. (scienceblog.com)
Since the response to MIS gene therapy is not the same for all patients, it will be important to first screen each patient's tumors to ensure they will respond" said Pepin. (scienceblog.com)
If further study confirms the susceptibility of chemoresistant tumors to this MIS gene therapy, the ability to inhibit tumor recurrence could significantly extend patient survival. (scienceblog.com)
Finally, we showed tumors can be imaged by single-photon computed tomography (SPECT) with PARP theranostic, [ 123 I]KX1, in a human ovarian cancer xenograft mouse model. (osti.gov)
RESULTS: Plasma levels of H3Cit-DNA and dsDNA were not elevated in women with borderline or malignant ovarian tumors compared with those of the benign group. (lu.se)
No differences were found in the survival analyses of malignant ovarian tumors by analyzing the dsDNA and H3Cit-DNA levels. (lu.se)
CONCLUSION: There is no association between NETs markers and ovarian tumors. (lu.se)
Clovis Oncology) for the treatment of women who have received ≥2 chemotherapies and whose tumors are associated with deleterious BRCA mutation-associated (germline and/or somatic) advanced ovarian cancer, as detected by the FDA-approved companion diagnostic test FoundationFocus CDxBRCA. (ahdbonline.com)
For patients with advanced ovarian cancer who have received ≥2 chemotherapies and whose tumors have deleterious BRCA mutations, the recommended dosage of rucaparib is 600 mg, orally, twice daily with or without food. (ahdbonline.com)
This study will evaluate the efficacy and safety of multiple biomarker-driven treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. (fredhutch.org)
8321 epithelial ovarian tumors were evaluated by Caris Life Sciences from 2009 to 2016 by multiplaform profiling, which included protein expression (IHC), NextGen sequencing (SEQ), and /or in-situ hybridization. (carislifesciences.com)
While CAR-T therapy has shown efficacy in some hematological tumors, reproducing the same results with solid tumors, such as ovarian cancer, has proven challenging. (biotuesdays.com)
This small percentage includes patients with stage IA or IB (grade 1) serous, mucinous, endometrioid, and Brenner tumors. (medscape.com)
Benign ovarian tumors usually grow slowly and rarely become malignant. (msdmanuals.com)

Benign ovarian masses include functional cysts (eg, corpus luteum cysts) and neoplasms (eg, benign teratomas). (msdmanuals.com)

A charity is to host a support roadshow for ovarian cancer patients in south Wales. (bbc.com)
Health Minister Edwina Hart said the plan recognised 'the important part' education, support and ongoing care played in the treatment and care of cancer patients. (bbc.com)
There is no question IP therapy should be much more widely offered, and advanced ovarian cancer patients should consult with gynecologic oncologists or medical oncologists with experience in this cancer who have the expertise to determine the best therapy," said Dr. Tewari. (sciencedaily.com)
We evaluated the reasons for non-enrolment of ovarian cancer patients in clinical trials. (nih.gov)
In a groundbreaking development, a new clinical trial in Saskatchewan is revolutionizing the way ovarian cancer patients receive treatment. (expresshealthcaremgmt.com)
Traditionally, treatment plans for ovarian cancer patients relied on limited research studies, which often yielded unclear results. (expresshealthcaremgmt.com)
As this innovative trial progresses, Dr. Hopkins aims to expand its reach beyond Saskatchewan, benefiting ovarian cancer patients across Canada. (expresshealthcaremgmt.com)
A: The clinical trial aims to provide ovarian cancer patients with more information and greater agency in deciding their treatment options. (expresshealthcaremgmt.com)
Furthermore, we demonstrated that viable tumor tissue from ovarian cancer patients can be used to screen tumor radiosensitivity ex-vivo, enabling the direct assessment of therapeutic efficacy. (osti.gov)
A recent study conducted at Denmark's Vejle Hospital, published in Pharmacological Research , provided evidence of delta-tocotrienol's benefits for cancer patients. (nutraceuticalsworld.com)
This is the first-ever clinical trial using tocotrienols in ovarian cancer patients, according to American River. (nutraceuticalsworld.com)
In the study of 23 advanced-stage ovarian cancer patients, tocotrienol was administered at a dosage of 300 mg three times a day, with bevacizumab given to patients at 10 mg/kg intravenously every three weeks. (nutraceuticalsworld.com)
In breast cancer patients, we believe there is now sufficient evidence to suggest that the administration of LHRHa could be considered a potential standard strategy to preserve ovarian function and might also play a role in increasing the likelihood of pregnancy after chemotherapy," said Lambertini. (oncologynurseadvisor.com)
With the rising trend of delaying childbearing, more breast cancer patients are diagnosed without having completed their families and thus it is vital to provide reliable fertility preservation methods for these young women. (oncologynurseadvisor.com)
A model based on artificial intelligence is able to predict the therapy outcome (measured by volumetric reduction of tumor lesions) in 80% of ovarian cancer patients. (technologynetworks.com)
This achievement stems from a recent study published in Nature Communications , conducted on 134 high-grade ovarian cancer patients. (technologynetworks.com)
Can Schlafen 11 Help to Stratify Ovarian Cancer Patients Treated with DNA-Damaging Agents? (muni.cz)
We discuss the current evidence of the correlation of Schlafen 11 expression in ovarian cancer with treatment outcomes and the potential use of Schlafen 11 as the key predictive and prognostic marker that could help to better stratify ovarian cancer patients treated with platinum-based chemotherapy or PARP inhibitors. (muni.cz)
Standardized aqueous mistletoe extracts have been applied to cancer patients for several decades as complementary medicine. (iiarjournals.org)
This study showed that complementary treatment with sME can beneficially reduce the side-effects of chemotherapy in cancer patients and thus improve quality of life. (iiarjournals.org)
For platinum-resistant or platinum-sensitive ovarian cancer patients, non-platinum drugs such as doxorubicin, paclitaxel, gemcitabine, docetaxel and etoposide are recommended ( 5 ). (frontiersin.org)
Are there any 'bad' supplements for Ovarian Cancer patients? (medhelp.org)
This app helps ovarian cancer patients get the support they need when they need it and helps to keep track of the details. (ucdavis.edu)
Many ovarian cancer patients will not be cured, and the side effects from the ongoing medications they take to control their disease can be hard to get used to," Brooks said. (ucdavis.edu)
Fig. 1: Complete gross tumour resection is associated with improved prognosis in advanced stage high-grade serous ovarian cancer patients. (nature.com)
Change the lives of cancer patients by giving your time and talent. (mdanderson.org)
Outcome of immature oocytes collection of 119 cancer patients during ovarian tissue harvesting for fertility preservation. (bvsalud.org)
We reviewed the records of 119 cancer patients who underwent ovarian tissue cryopreservation and immature oocyte harvesting for fertility preservation . (bvsalud.org)
Among patients with cancers associated with HBOC who are eligible for genetic testing according to clinical guidelines, 50% of male breast cancer patients and 39% of ovarian cancer patients underwent BRCA testing within 2 years of diagnosis. (cdc.gov)

BRCA1 and BRCA2 are genes with known mutations responsible for increasing the risk of hereditary breast and ovarian cancer and associated cancers in women, and for prostate and breast cancer among men. (clpmag.com)
Tier 1 BRCA genetic testing applications include adherence to USPSTF guidelines for hereditary breast and ovarian cancer (HBOC) risk assessment and FDA-approved companion diagnostics. (cdc.gov)

Serous ovarian cancer (SOC) is the most common histological subtype of EOC, accounting for 87% of advanced stage cases and 78% of total cases [ 2 ]. (oncotarget.com)
High-grade serous ovarian cancer (HGSOC) is the most common histologic subtype, accounting for over 70% of ovarian cancer cases while low-grade serous ovarian cancer (LGSOC) represents about 10% cases ( 3 ). (frontiersin.org)
Maximal effort cytoreductive surgery is associated with improved outcomes in advanced high-grade serous ovarian cancer (HGSOC). (nature.com)

Ovarian insufficiency is a failure of the ovary to function adequately in a woman younger than 40 years, in its role either as an endocrine organ or as a reproductive organ. (medscape.com)
As defined by the World Health Organization, ovarian insufficiency can be caused by a primary disorder in the ovary or it can occur as a result of secondary causes. (medscape.com)
Ovarian insufficiency is considered primary if the ovary fails to function normally in response to appropriate gonadotropin stimulation provided by the hypothalamus and pituitary. (medscape.com)
Ovarian insufficiency is considered secondary if the hypothalamus and pituitary fail to provide appropriate gonadotropin stimulation. (medscape.com)
Primary ovarian insufficiency (POI) (premature ovarian failure, premature menopause, or early menopause) is a condition characterized by amenorrhea, hypoestrogenism, and elevated serum gonadotropin levels in women younger than 40 years. (medscape.com)
A karyotype should be performed as a part of the routine evaluation after the diagnosis of primary ovarian insufficiency is established. (medscape.com)
Ovarian ultrasonography can be useful in the workup of patients with primary ovarian insufficiency, as it will identify those women with multifollicular ovaries and suggest the diagnosis of either autoimmune oophoritis or 17-20 desmolase deficiency. (medscape.com)
Dividing the continuum of ovarian insufficiency into 4 clinical states is the authors' preferred method to facilitate explanation. (medscape.com)
Occult primary ovarian insufficiency presents as unexplained infertility in a patient with a normal basal serum follicle-stimulating hormone (FSH) level. (medscape.com)
Next on the continuum, biochemical primary ovarian insufficiency presents as unexplained infertility in patients with an elevated basal serum FSH level. (medscape.com)
The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)

Patients with advanced-stage ovarian cancer often have a recurrence of the disease after primary treatment, and despite second and third line treatments, these patients eventually become chemotherapy-resistant with few therapeutic options. (nutraceuticalsworld.com)
The GERSOC-Trial will evaluate whether geriatric screening in elderly patients with advanced-stage ovarian cancer improves treatment completion and quality of life. (utwente.nl)

Here, we investigated a radioiodinated PARP inhibitor, [ 125 I]KX1, and show drug target specific DNA damage and subsequent killing of BRCA1 and non-BRCA mutant ovarian cancer cells at sub-pharmacological concentrations several orders of magnitude lower than traditional PARP inhibitors. (osti.gov)
Approximately 15% of patients with ovarian cancer have a mutation in the BRCA1 or BRCA2 gene. (ahdbonline.com)
Quest Diagnostics , Madison, NJ, is offering BRCAvantage™, a suite of four new lab-developed genetic tests (LDT) that identify mutations in BRCA1 and BRCA2 genes, which are associated with increased risk of inherited breast and ovarian cancers. (clpmag.com)
BRCA1 and BRCA2 mutations are also associated with increased inherited risk of ovarian, male breast, and other cancers. (clpmag.com)
Moreover, you can see on the bar graph that women with BRCA mutations had something like 30 to 40 times higher risk of having a low response to ovarian stimulation (especially the BRCA1 type), compared to those untested and negative. (hstalks.com)
Our studies also showed that women with BRCA1 mutations have lower ovarian reserve. (hstalks.com)
BRCA1 and BRCA2 ( BRCA ) genetic testing is supported by clinical guidelines to inform hereditary cancer risk for people with certain personal or family health histories of breast, ovarian, pancreatic, or prostate cancer, and to guide treatment decisions for people with these cancers. (cdc.gov)

Can artificial intelligence , or AI, improve treatment experiences, care and outcomes for people with ovarian cancer? (ucdavis.edu)
A recent nationwide study evaluated the utilization of germline BRCA testing among people with ovarian cancer and a subset of breast cancers associated with HBOC that are eligible for BRCA testing according to clinical guidelines, including breast cancer diagnosed before aged 45 years in women, triple-negative breast cancer diagnosed before aged 60 years in women, or breast cancer in men. (cdc.gov)

Approximately 50% of high-grade serous ovarian cancers (HGSOCs) have defects in genes involved in homologous recombination (HR) (i.e. (jci.org)

Since many people experience no symptoms at all or vague symptoms such as those listed above, it can be hard to know when someone should be screened for ovarian cancer. (aikenregional.com)

These data support the utility of PARP-1 targeted radiopharmaceutical therapy as a theranostic option for PARP-1 overexpressing ovarian cancers. (osti.gov)
In December 2014, the US Food and Drug Administration (FDA) granted accelerated approval to olaparib (Lynparza), an inhibitor of poly ADP-ribose polymerase (PARP), for the treatment of women with advanced ovarian cancer who received ≥3 chemotherapies and who have deleterious or suspected deleterious germline BRCA mutation, as detected by the FDA-approved companion diagnostic test BRACAnalysis CDx. (ahdbonline.com)
The utilization of BRCA testing increased significantly over the study years (37% to 68% for breast cancer, 23% to 53% for ovarian cancer), with acceleration of genetic testing in patients with ovarian cancer after the approval of PARP inhibitors. (cdc.gov)

Ovarian cancer is cancer of the ovaries - the female glands where eggs form and the hormones estrogen and progesterone are produced. (mdanderson.org)

The study revealed that when we look at the relationship between women's risk of ovarian cancer, as defined by their genetic blueprint, "there is an interplay between their genetics and specific genes that drives the very earliest stages of cancer development," said Gayther, also co-director of the Applied Genomics, Computation and Translational Core at Cedars-Sinai . (uclahealth.org)
Given the body of evidence presented in our study, we argue that oral contraceptives can dramatically reduce women's risk of ovarian and endometrial cancer, whereas their effect on lifetime risk of breast cancer is limited. (aacrjournals.org)

The event features a variety of sessions aiming to help patients feel more confident and come to terms with their diagnosis. (bbc.com)
Diane Powis spent more than 10 months bouncing from one doctor to the next before finally being "blindsided by" a diagnosis of stage 3 ovarian cancer. (curetoday.com)
In an interview with CURE®, Powis recently opened up about how her diagnosis taught her to ask for help, and how finding a community of fellow patients helped her realize that "knowledge is power. (curetoday.com)
Ovarian cancer is the fifth most common cause of cancer death in women in the U.S. According to the American Cancer Society, approximately 22,240 women in the U.S. received a new ovarian cancer diagnosis, while approximately 14,070 people died of the disease in 2018. (nutraceuticalsworld.com)
224 patients from a commercial registry (NCT02678754) with stage IIIC/IV EOC at diagnosis, or restaged to IIIC/IV EOC at the time of molecular profiling, were retrospectively divided into two cohorts based on whether or not the drugs they received matched their profile recommendations. (carislifesciences.com)
Ovarian cancer affects over five thousand women annually in Italy, adding to the thirty thousand patients who have already received a diagnosis. (technologynetworks.com)
From January 2011 through March 2020, 56% of patients with breast cancer and 35% of patients with ovarian cancer underwent genetic testing within one year of cancer diagnosis. (cdc.gov)
Diagnosis Ovarian cancer is often fatal because it is usually advanced when diagnosed. (msdmanuals.com)
The PPV of a clinical diagnosis of acute PID varies depending on epidemiologic characteristics and the clinical setting, with higher PPV among sexually active young (especially teenage) women and among patients attending STD clinics or from settings with high rates of gonorrhea or chlamydia. (cdc.gov)
Laparoscopic surgery 4 days after admission enabled definitive diagnosis of the tumor, confirmed torsion and removed the bulky ovarian fibroma, resulting in timely resolution of symptoms, short hospitalization, relatively low morbidity and a rapid return to her social and professional life. (medscape.com)

This pilot will roll out a standardised approach to prehabilitation for patients undergoing cytoreductive surgery (removal or destruction of all visible tumours present throughout the abdomen) for ovarian cancer in Wales. (ovarian.org.uk)
To date, the gold standard treatment for ovarian cancer involves cytoreductive surgery followed by platinum- and paclitaxel-based chemotherapy. (oncotarget.com)
The patient had recurrence of platinum resistance after secondary cytoreductive surgery, and it was difficult to continue chemotherapy after multiple lines of chemotherapy due to myelosuppression, renal impairment and other factors. (frontiersin.org)
Women with platinum-sensitive recurrent ovarian cancer (PSROC) can be treated with secondary cytoreductive surgery (SCS) and chemotherapy or chemotherapy alone. (frontiersin.org)

They're not for women who have a health condition that may make it hard to diagnose or treat ovarian cancer. (mdanderson.org)

Rarely, ascites and pleural effusion accompany ovarian fibromas;this triad of findings is called Meigs syndrome. (msdmanuals.com)
The Meigs' syndrome is a rare but well-known syndrome defined as the triad of benign solid ovarian tumor, ascites, and pleural effusion. (medscape.com)

the prognosis is poor for these patients. (ahdbonline.com)
Background: International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer (EOC) has a significantly better prognosis than stage III/IV EOC, with about 80% of patients surviving at 5 years (compared with about 20% of those with stage III/IV EOC). (omicsonline.org)
Compared with AR+ TNBC, "quad negative" patients differ in their prognosis, response to therapy, and molecular profiles. (carislifesciences.com)
The response to standard treatment and prognosis in patients with EOC is generally unsatisfactory. (jcancer.org)
ALG5 has been identified as an independent prognostic biomarker for poor prognosis in advanced HGSOC patients despite CGR. (nature.com)

Most ovarian cysts are related to ovulation, being either follicular cysts or corpus luteum cysts. (wikipedia.org)
Rarely, cysts may be a form of ovarian cancer. (wikipedia.org)
Ovarian cysts are present in about 16% of women after menopause and if present are more likely to be cancer. (wikipedia.org)
Nausea or vomiting Weight gain Other symptoms may depend on the cause of the cysts: Symptoms that may occur if the cause of the cysts is polycystic ovarian syndrome (PCOS) may include increased facial hair or body hair, acne, obesity and infertility. (wikipedia.org)
Rupture of large ovarian cysts can cause bleeding inside the abdominal cavity and in some cases shock. (wikipedia.org)
There are several types of functional cysts: Follicular cyst, the most common type of ovarian cyst. (wikipedia.org)
Non-functional cysts may include the following:[citation needed] An ovary with many cysts, which may be found in normal women, or within the setting of polycystic ovary syndrome Cysts caused by endometriosis, known as chocolate cysts Hemorrhagic ovarian cyst Dermoid cyst Ovarian serous cystadenoma Ovarian mucinous cystadenoma Paraovarian cyst Cystic adenofibroma Borderline tumoral cysts Transvaginal ultrasonography of a hemorrhagic ovarian cyst, probably originating from a corpus luteum cyst. (wikipedia.org)
Ovarian cysts are usually diagnosed by ultrasound, CT scan, or MRI, and correlated with clinical presentation and endocrinologic tests as appropriate. (wikipedia.org)
Follow-up imaging in women of reproductive age for incidentally discovered simple cysts on ultrasound is not needed until 5 cm, as these are usually normal ovarian follicles. (wikipedia.org)
Ovarian cysts or other ovarian masses are a common gynecologic issue. (msdmanuals.com)
is usually defined as a clinical syndrome, not by the presence of ovarian cysts. (msdmanuals.com)

This is also a proof of concept that gene therapies with the AAV9 vector can be used to deliver biologics for the treatment of ovarian cancer, and represents the first time this approach has been tested in this type of ovarian cancer model. (scienceblog.com)

For example, patients with lung cancers harboring KEAP1/NRF2 mutations have not benefited from treatment with immune checkpoint inhibitors and have poorer outcomes overall, explained Yap, who leads the IPN60090 clinical trial at MD Anderson. (mdanderson.org)
The emergence of poly (ADP-ribose) polymerase inhibitors (PARPi), antiangiogenics and immune checkpoint inhibitors (ICIs) have revolutionized the treatment of recurrent ovarian cancer. (frontiersin.org)

Omental and pelvic/ovarian locations (common for ovarian cancer spread) represented the majority of disease burden initially. (technologynetworks.com)
A pregnancy test is done to exclude ectopic pregnancy or threatened abortion in a patient with pelvic pain or abnormal uterine bleeding. (msdmanuals.com)
CIO Responsible for this publication: National Center for Prevention Services, Division of Sexually Transmitted Diseases and HIV Prevention PELVIC INFLAMMATORY DISEASE PID comprises a spectrum of inflammatory disorders of the upper genital tract among women and may include any combination of endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis. (cdc.gov)

The National Comprehensive Cancer Network and The Society of Gynecologic Oncology recommend that all patients with invasive or high-grade OC undergo genetic testing as knowledge of gene mutations can inform targeted treatment as well as cancer screening and prevention options for at-risk family members. (news-medical.net)
2 Mutations in the BRCA genes can lead to certain cancers, including ovarian cancer. (ahdbonline.com)
In part 2, I'll be talking to you about how BRCA mutations affect ovarian reserve and reproduction. (hstalks.com)
In a more recent study, we confirmed these findings, where we compared the ovarian stimulation response between women who were BRCA-negative or untested, and those who had BRCA mutations. (hstalks.com)

Considering the patient's serious clinical condition and assuming that she had Meigs' syndrome with a twisted large ovarian mass and possible hemolytic anemia, we first concentrated on effective medical management of our patient and chose the most appropriate surgical treatment after laparoscopic examination. (medscape.com)

In some cases, normal ovarian function may even return for a period of time. (medscape.com)

The approach may increase the chances of pregnancy after breast cancer treatment by preventing premature ovarian failure (POF). (oncologynurseadvisor.com)

Participant must have histologically documented, platinum resistant, advanced (metastatic and/or unresectable) high-grade serous/endometrioid ovarian, primary peritoneal, or fallopian tube cancer. (uclahealth.org)

The researchers recruited 497 patients with recurrent or persistent ovarian, fallopian tube or primary peritoneal cancer. (upmc.com)
PATIENTS AND METHODS: Peripheral blood samples were obtained from 199 patients admitted for primary surgery of adnexal masses. (lu.se)
We developed a preclinical platform for HRD HGSOCs that includes primary tumor cultures, patient-derived xenografts (PDXs), and molecular imaging. (jci.org)
The orthotopic PDX model emulates the natural progression of HGSOC, including development of a primary ovarian tumor and metastasis to abdominal viscera. (jci.org)
Despite maximal cytoreduction at the time of primary surgery and platinum-based adjuvant chemotherapy, 70-80% of patients with advanced ovarian cancer will relapse ( 4 ). (frontiersin.org)
To conduct the study, the researchers are recruiting 200 women who have been diagnosed with ovarian, fallopian tube or primary peritoneal cancer . (ucdavis.edu)
British Gynaecological Cancer Society (BGCS) epithelial ovarian/fallopian tube/primary peritoneal cancer guidelines: recommendations for practice. (nature.com)
All patients with stage II or higher cancer should be considered for front-line chemotherapy based on burden of disease and ability to achieve optimal primary resection. (medscape.com)

The use of LHRHa was originally conceived to preserve ovarian function rather than fertility, and only five of the studies reported on pregnancies after breast cancer treatment. (oncologynurseadvisor.com)
In part 1, we talked about ovarian reserve and chemotherapy, how we make decisions for fertility preservation, and how we approach fertility preservation in women with breast cancer. (hstalks.com)
Aging is associated with a decline in the number of ovarian follicles, menstrual irregularities, ovarian hormonal deficiency, anovulation, decreased fertility, and, finally, a complete and irreversible cessation of menses known as menopause, usually occurring at a mean age of 51 years. (medscape.com)
Evaluating ovarian function or ovarian reserve is one of the most important aspects in evaluating woman's fertility testing. (scrcivf.com)

Methods: We analysed tumour samples from 144 patients (29 of whom relapsed) with stage I EOC gathered from two independent tumour tissue collections (A and B), both with a median follow-up of 9 years. (omicsonline.org)
89 samples from tumour tissue collection A were stratified into a training set (51 samples, 15 of which were from patients who relapsed) for miRNA signature generation, and into a validation set (38 samples, seven of which were from patients who relapsed) for signature validation. (omicsonline.org)
Tumour tissue collection B (55 samples, seven of which were from patients who relapsed) was used as an independent test set. (omicsonline.org)
We provide background information about the function of Schlafen 11, its evaluation in tumor tissue, and its prevalence in ovarian cancer. (muni.cz)
The aim of this study was to evaluate post-thawing outcomes of immature oocytes collected both by transvaginal aspiration and from excised ovarian tissue . (bvsalud.org)

The current study employed a modified form of the MIS gene, developed by Pepin to generate protein of greater purity and effectiveness, combined with the accepted viral vector AAV9 for delivery into the peritoneal cavity, a common site for the recurrence of ovarian cancer. (scienceblog.com)

A recent study suggests that patients with advanced ovarian cancer who undergo intensive treatment with chemotherapy that bathes the abdomen are significantly more likely to live longer than those who receive standard intravenous (IV) chemotherapy. (sciencedaily.com)
Patients with advanced ovarian cancer who undergo intensive treatment with chemotherapy that bathes the abdomen are significantly more likely to live longer than those who receive standard intravenous (IV) chemotherapy, according to a study that analyzed long-term follow-up from two landmark Gynecologic Oncology Group (GOG) trials comprising 876 patients. (sciencedaily.com)
Future efforts are needed to explore the feasibility of the multichannel information delivery model and its effectiveness in promoting awareness and acceptance of genetic testing among patients and family members and in empowering them in cancer treatment and care. (news-medical.net)
Robert Wenham , MD, MS, FACOG, FACS, a gynecologic oncologist and chair of the Gynecologic Oncology Program at Moffitt Cancer Center, discusses novel immunotherapy combinations for the treatment of patients with ovarian cancer . (moffitt.org)
Patients with responding disease continue treatment for up to 12 months in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
Thanks to a generous donation from the Donald E. Kramer family of Kramer Tractor, necessary equipment has been funded to enhance the treatment process and improve the overall quality of life for patients with ovarian cancer. (expresshealthcaremgmt.com)
By providing patients with a more detailed understanding of their situation, they are empowered to make evidence-based decisions about their treatment options. (expresshealthcaremgmt.com)
Our preclinical data suggest that IPN60090 may be effective in underserved groups of patients who need better treatment options, and we look forward to results from our ongoing clinical trials. (mdanderson.org)
These patient groups in particular, which represent distinct niches within those cancer types, are in need of more effective treatment options. (mdanderson.org)
Following an initial assessment consultation, a personalised prehabilitation programme will be designed for the patient for implementation throughout their treatment pathway. (ovarian.org.uk)
In 2018, the FDA approved bevacizumab (Avastin), an anti-angiogenic agent, for frontline treatment of ovarian cancer after surgery, based on its ability to reduce disease progression by 38% in a double-blind, placebo-controlled, multicenter study. (nutraceuticalsworld.com)
In Europe, the drug has been used for first-line and recurrent ovarian cancer treatment for much longer, since 2011, and shows similar promising results. (nutraceuticalsworld.com)
Compared to a typically reported median PFS of 2-4 months and median OS of 5-7 months, combined treatment of bevacizumab and delta-tocotrienol nearly doubled survival, allowing patients to reach a median PFS of 6.9 months and a median OS of 10.9 months. (nutraceuticalsworld.com)
The study treatment was shown to have low toxicity, with only three patients discontinuing their medications due to well-known side effects of bevacizumab therapy. (nutraceuticalsworld.com)
Commenting on the research, Dr. Barrie Tan, president of American River Nutrition said that "as one of the most deadly cancers in women, ovarian cancer needs further attention, and I applaud Dr. Jakobsen and his group for their novel approach in finding alternative treatment options for these patients. (nutraceuticalsworld.com)
Regardless of mutation status, systemic treatment for advanced ovarian cancer most often includes platinum-based cytotoxic chemotherapy. (ahdbonline.com)
Women with these gene abnormalities who have tried at least two chemotherapy treatments for their ovarian cancer now have an additional treatment option," stated Richard Pazdur, MD, Director of the FDA's Office of Hematology and Oncology Products. (ahdbonline.com)
Patients with recurrent epithelial ovarian cancer (EOC) have limited treatment options. (carislifesciences.com)
For all patients clinicians collected clinical data, including demographic information and treatment details, as well as blood biomarkers like CA-125 and circulating tumor DNA (ctDNA). (technologynetworks.com)
Platinum-based chemotherapy has been the cornerstone of systemic treatment in ovarian cancer. (muni.cz)
At the date of the review finished, 15 of 33 (45.5%) patients remained on the combined treatment of apatinib and etoposide, while the other 18 (54.5%) had discontinued. (jcancer.org)
The most common adverse event was mucositis oral (60.6%), which caused the treatment discontinued in 4 (12.1%) patients. (jcancer.org)
All patients were provided with standard tumordestructive treatment schedules and complementarily treated with sME or Lentinan during chemotherapy according to treatment protocol. (iiarjournals.org)
Biometrically, the patients of the control and sME treatment group were comparable regarding distribution, clinical classification (WHO) and treatment protocols. (iiarjournals.org)
Anixa Biosciences (NASDAQ:ANIX), in partnership with Moffitt Cancer Center, commenced treatment of the third patient in the ongoing clinical trial of Anixa's novel chimeric antigen receptor T-cell (CAR-T) therapy for ovarian cancer. (biotuesdays.com)
Assuming safety is validated in the third patient, as was the case for the first two patients, Anixa expects to begin treatment of the second cohort in the fourth quarter of 2023. (biotuesdays.com)
However, many of the chemotherapeutic agents are nephrotoxic and can promote kidney dysfunction, which affect the efficacy of cancer treatment and the survival of the patient. (frontiersin.org)
The patient accepted Niraparib-based treatment regimen after multi-line chemotherapy-induced stage 4 chronic kidney disease. (frontiersin.org)
In patients with relapsed ovarian cancer, treatment becomes increasingly challenging to subsequent therapies because of renal impairment and emerging drug resistance. (frontiersin.org)
Niraparib-based treatment regimen may be a good choice for patients with well-differentiated serous adenocarcinoma of the ovary who are intolerant to chemotherapy. (frontiersin.org)
Systemic treatment is still the standard of care in relapsed ovarian cancer. (frontiersin.org)
Brooks is one of the co-principal investigators for what is being call the VIRGO project or Value-Based Integrated Recommendation Software Guiding Ovarian treatment. (ucdavis.edu)
In older patients, standard treatment is often withheld or prematurely stopped due to suspected frailty. (utwente.nl)
It remains challenging to distinguish fit elderly patients who can endure standard therapy from frail patients who may benefit from an adapted treatment strategy. (utwente.nl)
patients who are considered unfit will be referred to a geriatrician for analysis and treatment advice. (utwente.nl)
Discussion: This trial aims to gather evidence for the use of geriatric screening in treatment decision-making in elderly patients with advanced ovarian cancer. (utwente.nl)
Surgery is the initial modality of treatment for stage I-IVA epithelial ovarian cancer. (medscape.com)
Bevacizumab is approved as a maintenance treatment in first-line setting in advanced-stage III-IV ovarian cancers, because GOG-0218 and ICON-7 phase III trials demonstrated progression-free survival benefits. (ucl.ac.uk)
In the ICON-7 trial dataset, the OS of patients within the low- and high-risk disease groups was assessed according to treatment arms and KELIM. (ucl.ac.uk)

A retrospective study reported AKI in 40.4% of patients ( 8 ). (frontiersin.org)

Frances Reid, public affairs director for Target Ovarian Cancer, said: 'Currently women being treated at Velindre Hospital for ovarian cancer do not have the support of clinical nurse specialists leaving them without vital access to support and information about local services. (bbc.com)
Sara Naylor, media manager of Target Ovarian Cancer, said: 'Because ovarian cancer is one of the less common cancers, women might find it difficult to come into contact with people going through the same experiences. (bbc.com)
This event is an opportunity to put women in touch with others who have got ovarian cancer. (bbc.com)
Every year, more than 22,000 women are diagnosed with ovarian cancer and more than 15,000 die of the disease. (sciencedaily.com)
PITTSBURGH - An online symptom management tool that harnesses the problem-solving benefits of expressive writing could help women with ovarian cancer better manage complex symptoms, according to a new study led by a University of Pittsburgh and UPMC nurse-scientist. (upmc.com)
Women with ovarian cancer experience an average of 14 concurrent symptoms, so symptom management is very complex. (upmc.com)
In 2022 , about 20,000 women will be diagnosed with ovarian cancer in the U.S., and more than 12,000 will die. (upmc.com)
There's over 200,000 women, closer to three (hundred thousand), living with ovarian cancer right now. (curetoday.com)
Furthermore, the PROMISE-GIM6 study found that adding LHRHa made no difference to disease-free survival, even within the subgroup of women with hormone-receptor-positive breast cancer, who accounted for the majority of the patients enrolled in the study. (oncologynurseadvisor.com)
1 The National Cancer Institute estimates that 22,280 women were diagnosed with ovarian cancer in 2016 and 14,240 women died from the disease. (ahdbonline.com)
In women aged 40 years or older, the expected physiologic decline of ovarian function that takes place with aging is termed perimenopause or the menopausal transition . (medscape.com)
Most women with POI retain intermittent ovarian function for many years, and, unlike women who are menopausal, pregnancies may occur. (medscape.com)
Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death among women in the United States, with approximately 21,290 new patients and 14,180 deaths in 2015 [ 1 ]. (oncotarget.com)
QUADRA study reported clinical benefit of niraparib in fourth or later line therapy among women with heavily pretreated ovarian cancer, especially in HRD-positive platinum-sensitive ovarian cancer ( 10 ). (frontiersin.org)
The findings, published online in the journal Nature Genetics , will both help identify women who are at highest risk of developing ovarian cancer and pave the way for identifying new therapies that can target these specific genes. (uclahealth.org)
Those researchers compared the genetic profiles of about 25,000 women with ovarian cancer and 45,000 women without the disease. (uclahealth.org)
Unfortunately, this causes approximately two-thirds of women who have ovarian cancer to be diagnosed at a late stage of the disease, when it is difficult to treat. (aikenregional.com)
One sign of ovarian cancer that many women may miss is a feeling of being full quickly when eating. (aikenregional.com)
It's understandable that many women don't know when to be concerned enough about possible ovarian cancer symptoms to see a doctor. (aikenregional.com)
However, only a small percentage of women with epithelial ovarian cancer can be treated with surgery alone. (medscape.com)
Women with any stage of epithelial ovarian cancer should be considered for clinical trials if available. (medscape.com)
At this time, ovarian cancer screening is recommended only for women at increased or high risk. (mdanderson.org)
CA 125 is usually measured in postmenopausal women with an ovarian mass, but its use in premenopausal women requires clinical judgment. (msdmanuals.com)

This case highlights the difficulties that may be encountered in the management of patients with Meigs' syndrome, including potential misdiagnosis of the tumor as a malignant ovarian neoplasm that may influence the medical and surgical approach and the adverse impact that Meigs' syndrome can have on the patient's condition, especially if it is associated with acute pain and severe anemia. (medscape.com)

A study reported acute kidney injury (AKI) in 10880 patients of 163,071 patients on systemic therapy for cancer with an cumulative incidence of 9.3% ( 7 ). (frontiersin.org)
This indicates increased risk of AKI with systemic therapy for ovarian cancer which cannot be ignored. (frontiersin.org)

An ovarian cyst is a fluid-filled sac within the ovary. (wikipedia.org)

The modified MIS/AAV9 construct was tested against tumor cells taken from ascites fluid that had accumulated in the abdomens of several patients with recurrent ovarian cancer. (scienceblog.com)

A team of researchers at the UCLA Jonsson Comprehensive Cancer Center, Cedars-Sinai Cancer and Dana-Farber Cancer Institute have newly identified 34 genes that are associated with an increased risk for developing the earliest stages of ovarian cancer. (uclahealth.org)
To pinpoint the genes, the researchers analyzed patient data to try to find genetic variants in the DNA blueprint that explain the patient disease status. (uclahealth.org)
The idea of combing through large amounts of data to establish which specific genes drive ovarian cancer development may seem simple, but there are thousands of possible gene targets that can be affected by numerous mechanisms, so putting the pieces together is a huge computational and statistical effort, Gayther said. (uclahealth.org)
To help identify the genes in these particular regions, the team compared the large-scale genetic data from the Ovarian Cancer Association Consortium with a different data type that describes the expression of genes in ovarian and other tissues. (uclahealth.org)
Through this computational technique, the team identified 34 genes that are associated with an increased risk for developing ovarian cancer. (uclahealth.org)

The goal of the clinical trial is to involve 100 patients and yield results that will lead to improved patient outcomes and a higher quality of care. (expresshealthcaremgmt.com)
Previous in vitro and in vivo studies, including a clinical trial in patients with pancreatic cancer, showed that delta-tocotrienol was especially active against malignancies, compared to other vitamin E isoforms. (nutraceuticalsworld.com)
Results from a clinical trial of olaparib in 137 patients with BRCA mutation-positive ovarian cancer who had received ≥3 chemotherapy regimens demonstrated an investigator-assessed overall response rate of 34% and a median duration of response of 7.9 months. (ahdbonline.com)

In this study, we used 7 publicly available microarray datasets to identify gene signatures related to recurrence in optimally debulked SOC patients, and validated their expressions in an independent clinic cohort of 127 patients using immunohistochemistry (IHC). (oncotarget.com)
We identified a two-gene signature including KCNN4 and S100A14 which was related to recurrence in optimally debulked SOC patients. (oncotarget.com)
If you've had ovarian cancer, you need a different plan to check for cancer recurrence. (mdanderson.org)

Published today in the Journal of Clinical Oncology , the study found that patients who used nurse-led and self-directed versions of the tool reported a better sense of control over symptoms compared to enhanced usual care. (upmc.com)
It can be overwhelming for patients and challenging for providers, who may not have time to address these symptoms in a typical 15-minute appointment," said lead author Heidi Donovan, Ph.D., R.N., professor of health and community systems in Pitt's School of Nursing and obstetrics, gynecology and reproductive services in the School of Medicine . (upmc.com)
There's a vast difference in quality of life between patients who manage symptoms successfully and those who don't, both throughout chemotherapy and afterwards," said Donovan, who is also director of the Gynecologic Oncology Family CARE Center at UPMC Magee-Womens Hospital . (upmc.com)
Donovan and her team developed a new symptom management approach called Written Representational Intervention to Ease Symptoms, or WRITE Symptoms , which guides patients to reflect on how they experience a symptom: what causes it, what makes it worse, how it feels, how it impacts their daily life and how they've tried to manage it. (upmc.com)
Using evidence-based symptom management techniques, we then help patients develop strategies for addressing target symptoms. (upmc.com)
The researchers are now developing a mobile health app that will train family members and other caregivers to help their loved ones with ovarian cancers better manage symptoms. (upmc.com)
If you notice that you've been feeling full quickly even though you haven't eaten much, or you have other symptoms of ovarian cancer, talk to your doctor. (aikenregional.com)
If you have symptoms that persist and you haven't found a valid explanation for them, it may also be a good idea to talk to your doctor or gynecologist about the possibility of whether your symptoms may be attributable to ovarian cancer. (aikenregional.com)
Because the symptoms are often vague, ovarian cancer is often diagnosed at a later stage , when it's harder to treat. (mdanderson.org)
It's important to be aware of your body and be on the lookout for changes that might be symptoms of ovarian cancer . (mdanderson.org)
These symptoms do not always mean you have ovarian cancer, but it's a good idea to discuss them with your health care provider if they are new, last more than a few weeks or happen more than 12 times a month. (mdanderson.org)

Results of the open-label trial suggested that American River Nutrition -manufactured delta-tocotrienol in combination with bevacizumab had additive effects in chemotherapy refractory ovarian cancer, possibly conferred by the anti-angiogenic activity of both compounds. (nutraceuticalsworld.com)
The authors noted that "the present study indicates that the combination of bevacizumab and delta-tocotrienol is effective in multiresistant ovarian cancer. (nutraceuticalsworld.com)
Olaparib plus bevacizumab as first-line maintenance in ovarian cancer. (nature.com)
The GOG 252 authors concluded that the toxicity and patient-reported outcomes support selection of the regimen consisting of IV carboplatin AUC 6 day 1, dose-dense paclitaxel 80 mg/m 2 IV once weekly, and bevacizumab 15 mg/kg IV day 1 given in 3-week cycles. (medscape.com)

Patient disease stabilization was high at 70%, with increased survival, which approximately doubled. (nutraceuticalsworld.com)
An initial calculation found that POF incidence was reduced by 64%, approximately two-thirds, in patients who received LHRHa. (oncologynurseadvisor.com)
Patients enrolled in this second cohort will receive approximately three times the cell dose, compared with the first cohort. (biotuesdays.com)
Background: Approximately 40% of the newly diagnosed patients with advanced ovarian cancer are aged 70 years or older. (utwente.nl)
Otherwise, patients should have measurement of 17-hydroxyprogesterone (17-OHP) under basal conditions ideally in the early morning, and if abnormal, they should have measurement of 17-OHP one hour after the administration of synthetic ACTH, 250 microg i.v., to screen for CAH, which is present in approximately 2% of hyperandrogenic patients. (qxmd.com)
In 1990 there were approximately 43,469 patient records provided by 1,684 doctors that participated in the survey. (cdc.gov)

Newly Diagnosed With Ovarian Cancer? (curetoday.com)

However, 20% of patients with stage I EOC relapse within 5 years. (omicsonline.org)
However, despite complete gross resection (CGR), there is a percentage of patients who will relapse and die early. (nature.com)

These cells should be expanded ex vivo and stimulated specifically for use in the immunotherapy of ovarian cancer. (nih.gov)
Patients have access to leading-edge care, including immunotherapy and other targeted treatments. (ucdavis.edu)

Implanted with ovarian cancer1

Carcinoma7

Tumors17

Neoplasms1

Cancer patients29

Hereditary breast and ovarian cancer2

Serous ovarian cancer3

Insufficiency11

Advanced-stage ovarian cancer2

BRCA17

People with ovarian cancer2

High-grade serous ovarian1

Screened for ovarian cancer1

PARP3

Ovaries1

Women's risk of ovarian2

Diagnosis10

Cytoreductive surgery4

Treat ovarian cancer1

Pleural effusion2

Prognosis5

Cysts11

Type of ovarian1

Inhibitors2

Pelvic3

Mutations4

Large ovarian1

Normal ovarian1

Premature ovarian1

Fallopian Tube Cancer1

Primary8

Fertility4

Tissue5

Peritoneal1

Treatment39

Retrospective Study1

Women23

Malignant1

Systemic2

Ovary1

Ascites1

Genes5

Clinical trial3

Recurrence3

Symptoms11

Bevacizumab4

Approximately6

Newly diagnosed1

Relapse2

Immunotherapy2