• Optic nerve glioma (also known as optic pathway glioma) is the most common primary neoplasm of the optic nerve. (medscape.com)
  • Up to 20% of NF1 patients will develop optic pathway glioma (OPG) and most of them will require treatment in order to preserve visual integrity [ 9 ]. (biomedcentral.com)
  • Does chemotherapy affect the visual outcome in children with optic pathway glioma? (prinsesmaximacentrum.nl)
  • INTRODUCTION: Overall prognosis for optic pathway glioma (OPG) in children is excellent. (prinsesmaximacentrum.nl)
  • Children with NF type 1 (NF1) can develop a kind of brain tumor known as an optic pathway glioma. (technologynetworks.com)
  • Promising new cellular and in vivo models for understanding the musculoskeletal abnormalities in NF1, the development of NF2 or SWN associated schwannomas, and clarifying the cells that give rise to NF1-associated optic pathway glioma were presented. (escholarship.org)
  • Risk Factors for Treatment Refractory and Relapsed Optic Pathway Glioma in Children with Neurofibromatosis Type 1. (cdc.gov)
  • Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003. (epfl.ch)
  • The primary purpose of this study is to test whether GD2-CAR T cells can be successfully made from immune cells collected from children and young adults with H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) or spinal H3K27M-mutant diffuse midline glioma (DMG). (stanford.edu)
  • Diffuse intrinsic pontine glioma (DIPG) , also known as diffuse midline glioma (DMG). (cincinnatichildrens.org)
  • Optic pathway gliomas are benign tumors that are classified as pilocytic astrocytomas . (medscape.com)
  • They constitute 50% of primary optic nerve tumors and 1.5-4% of all orbital tumors. (medscape.com)
  • NF Central Plains' Virtual Day of iNFormation begins with a warm welcome from members of our NF community before Dr. Angela Hirbe shares an overview of NF, how patients are diagnosed, what plexiform neurofibromas and malignant peripheral nerve-sheath tumors (MPNSTs) are, and the exciting research and newly approved treatments for these tumors. (nfnetwork.org)
  • Visual field loss is frequent in patients with brain tumors, worsening their daily life and exacerbating the burden of disease, and no supportive care strategies exist. (frontiersin.org)
  • Two patients, one with homonymous hemianopia and the other with bitemporal hemianopia, consecutive to pediatric brain tumors, with no prior visual rehabilitation performed 15 min of home-based audiovisual stimulation every 2 days for 6 weeks (case 2) and 7 weeks (case 1) between February and August 2020. (frontiersin.org)
  • These tumors are one of the most common tumors in neurofibromatosis type I (NF-I), occurring in about 10% of NF-I patients. (uab.edu)
  • Loss of functional NF1 leads to increased activation of the ERK/MAPK pathway and growth of optic pathway gliomas (OPG), or benign tumors that grow along the visual pathway, which can cause vision loss and become a blinding disease. (health.mil)
  • Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. (biomedcentral.com)
  • The same pathway is also activated in plexiform neurofibromas (PNs) which are low-grade tumors involving peripheral nerves in patients with neurofibromatosis type 1 (NF1). (biomedcentral.com)
  • Pediatric low grade gliomas (PLGG) which include pilocytic astrocytoma (PA) are the most frequent brain tumors and represent 25-30% of central nervous system tumors in children [ 1 ]. (biomedcentral.com)
  • While some patients can be cured with surgery alone, more than 70% need complimentary treatments due to the location of tumors that preclude resection [ 2 ]. (biomedcentral.com)
  • Less common but potentially more serious manifestations include optic nerve and other central nervous system gliomas, malignant peripheral nerve sheath tumors, scoliosis, tibial dysplasia, vasculopathy, and gastrointestinal, endocrine, or pulmonary disease. (nih.gov)
  • 1,2 Patients with NF1 are predisposed to CNS tumors, with 15-20% developing gliomas. (tamhsc.edu)
  • 3 Pediatric Low-Grade Gliomas (pLGG) are the most common form of pediatric CNS neoplasms, accounting for 30% of all pediatric brain tumors. (tamhsc.edu)
  • We have observed a toxicity syndrome, distinct from CRS and ICANS, in patients treated with cell therapies for tumors in the central nervous system (CNS), which we term tumor inflammation-associated neurotoxicity (TIAN). (stanford.edu)
  • To facilitate the safe administration of cell therapies for patients with CNS tumors, we define TIAN, propose a toxicity grading scale for TIAN syndrome and discuss the potential management of this entity, with the goal of standardizing both reporting and management. (stanford.edu)
  • The findings, available online in Nature Communications , suggest that reprogramming T cells in brain tumor patients to act more like T cells in asthma patients could be a new approach to treating brain tumors. (technologynetworks.com)
  • These tumors grow within the optic nerves, which carries messages between the eyes and the brain. (technologynetworks.com)
  • Gutmann, director of the Washington University NF Center , noted an inverse association between asthma and brain tumors among his patients more than five years ago but didn't know what to make of it. (technologynetworks.com)
  • It wasn't until more recent studies from his lab began to reveal the crucial role that immune cells play in the development of optic pathway gliomas that he began to wonder whether immune cells could account for the association between asthma and brain tumors. (technologynetworks.com)
  • The purpose of this Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. (mayoclinic.org)
  • Patients with genetic changes or abnormalities (mutations) may benefit more from treatment which targets their tumor's particular genetic mutation, and may help doctors plan better treatment for patients with solid tumors or non-Hodgkin lymphomas. (mayoclinic.org)
  • JPA is the most common type of glioma in children and adolescents, accounting for approximately 15.6% of all brain tumors and 5.4% of all gliomas. (aao.org)
  • Patients come from around the world come to Cincinnati Children's for expert treatment for brain tumors in children or young adults. (cincinnatichildrens.org)
  • Some patients are newly diagnosed and others seek care for recurrent or treatment-resistant tumors. (cincinnatichildrens.org)
  • Visual pathway gliomas are the most common type of tumor encountered, but other types of low-grade and less frequently high-grade, primary central nervous system tumors may occur. (medlink.com)
  • A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042). (dukecancerinstitute.org)
  • Plexiform neurofibromas are seen in 30-50% of patients. (wikipedia.org)
  • A minimum of two of the following criteria are required for diagnosis: six or more café-au-lait spots, two or more cutaneous neurofibromas, one or more plexiform neurofibromas, axillary or groin freckling, optic glioma, two or more Lisch nodules, distinctive bony lesions, and a first-degree relative with NF1. (dovepress.com)
  • 1 , 2 The syndrome is characterized by a combination of clinical traits: café au lait macules, Lisch nodules (iris hamartomas), neurofibromas (cutaneous, subcutaneous, plexiform), optic pathway gliomas, and bone dysplasia. (ajnr.org)
  • Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder of the nervous system that is associated with significant morbidity, including cutaneous and plexiform neurofibromas, optic pathway gliomas, skin pigmentation, bone deformities, neurocognitive deficits, and an increased risk of several types of cancer. (nfnetwork.org)
  • TINT: A phase II study of trametinib in paediatric, adolescent and young adult patients with Neurofibromatosis type 1 associated plexiform neurofibromas or progressive optic pathway gliomas. (anzchog.org)
  • 95% CI, 0%-7%) had discrete cutaneous or plexiform neurofibromas, typical NF1 osseous lesions, or symptomatic optic pathway gliomas. (duke.edu)
  • The term phakomatosis originated in 1923, when the Dutch ophthalmologist van der Hoeve used the term phakoma to refer to a "mother spot" or birthmark, a physical characteristic common to patients with tuberous sclerosis and neurofibromatosis that he examined. (wikipedia.org)
  • The first clinical description was made in "Monstrorum Historia" by an Italian physician and naturalist named Ulisse Aldrovandi who described a patient with probable neurofibromatosis type I in 1592. (wikipedia.org)
  • Optic pathway gliomas are seen in 15-20% of patients with neurofibromatosis type 1. (wikipedia.org)
  • Neurocognitive impairment, attention-deficit hyperactivity disorder, autism spectrum disorder and behavioral disorders are also commonly seen in patients with neurofibromatosis type 1. (wikipedia.org)
  • Dr. Iloeje specifically highlights what clinical trials are, what SpringWorks Therapeutics is currently working on, and what trials are available for neurofibromatosis patients. (nfnetwork.org)
  • The second patient was a child with neurofibromatosis type 1 who developed a pigmented peripapillary lesion following excision of an optic nerve glioma. (nih.gov)
  • To evaluate correlations between choroidal abnormalities, Lisch nodules, and age in patients with neurofibromatosis type 1 (NF1), we examined ten cases with NF1 using near-infrared reflectance imaging. (dovepress.com)
  • The aim of this study was to characterize the radiologic presentation of patients with neurofibromatosis type 1 with widespread spinal disease and to correlate it to clinical presentation and outcome. (ajnr.org)
  • We conducted a historical cohort study of adult patients with neurofibromatosis type 1 with spinal involvement. (ajnr.org)
  • Two hundred fifty-seven adult patients with neurofibromatosis type 1 are followed in our center. (ajnr.org)
  • NF1 mutations are mainly found in patients with neurofibromatosis type 1 (NF1). (biomedcentral.com)
  • Approximately 5 to 20% of all patients with neurofibromatosis type I (162200) carry a heterozygous deletion of approximately 1.4 Mb involving the NF1 gene and contiguous genes lying in its flanking regions (Riva et al. (nih.gov)
  • To investigate the mechanisms of development and potential treatment options for pediatric low-grade glioma and optic glioma in children with neurofibromatosis type 1. (tamhsc.edu)
  • A literature review was performed through online search in the PubMed database from 2017-2023 using the following keywords: "Neurofibromatosis Type 1," "pediatric low-grade glioma," "pediatric optic glioma," "mechanism," and "treatment. (tamhsc.edu)
  • The molecular landscape of glioma in patients with Neurofibromatosis 1. (tamhsc.edu)
  • Temporal, spatial, and genetic constraints contribute to the patterning and penetrance of murine neurofibromatosis-1 optic glioma. (tamhsc.edu)
  • Due to the potential increased susceptibility of patients with neurofibromatosis 1 to the deleterious side effects of radiation therapy, such as mutagenesis and vasculopathy, alternative treatments are required for patients with progressive disease. (medlink.com)
  • The author reviews the role of chemotherapy for gliomas associated with neurofibromatosis 1 and its efficacy on disease control and visual outcome. (medlink.com)
  • He also discusses the potential role of molecularly targeted therapy in the treatment of neurofibromatosis 1-associated gliomas. (medlink.com)
  • Neurofibromatosis 1 has protean manifestations, of which intracranial gliomas are one of the most common. (medlink.com)
  • Gliomas in children with neurofibromatosis 1, if requiring treatment, may be chemotherapy-sensitive, and radiotherapy should be used as a last resort, given potential long-term sequelae. (medlink.com)
  • In distinction, an individual is diagnosed to have neurofibromatosis 2 if the person has bilateral eighth nerve masses seen with appropriate imaging techniques or a first degree relative with neurofibromatosis 2 and either: (1) a unilateral eighth nerve mass, (2) Two or more of the following: neurofibroma, meningioma, glioma, schwannoma, or juvenile posterior subcapsular lenticular opacity. (medlink.com)
  • Calvarial mass as a presenting feature of neurofibromatosis type 2 in a pediatric patient. (dukecancerinstitute.org)
  • Segal, Laura, Mahshad Darvish-Zargar, Marie-Emmanuelle Dilenge, June Ortenberg, and Robert C. Polomeno, "Optic Pathway Gliomas in Patients with Neurofibromatosis Type 1: Follow-up of 44 Patients. (retinarevealed.com)
  • We report a patient with neurofibromatosis type 1 who showed intractable mesial temporal lobe epilepsy. (j-epilepsy.org)
  • OBJECTIVE: To determine the frequency, mutational spectrum, and phenotype of neurofibromatosis type 1-like syndrome (NFLS) in a large cohort of patients. (duke.edu)
  • In a second cross-sectional study, 1318 unrelated anonymous samples collected in 2003-2007 from patients with a broad range of signs typically found in neurofibromatosis type 1 (NF1) but no detectable NF1 germline mutation underwent SPRED1 mutation analysis. (duke.edu)
  • Lisch nodules (benign hamartomas of the iris) are seen in almost all patients but they do not cause any visual or ocular impairment. (wikipedia.org)
  • No positive correlation was found between the number of Lisch nodules and patient age (Spearman's rank correlation coefficient ρ=0.117, P =0.7414). (dovepress.com)
  • In conclusion, choroidal abnormalities tend to increase with patient age and are correlated with the number of Lisch nodules. (dovepress.com)
  • 2 - 6 To our knowledge, there have been few reports of correlations between choroidal abnormalities, Lisch nodules, and patient age. (dovepress.com)
  • 3 , 4 Herein, we examined ten cases of NF1 using near-infrared reflectance imaging to evaluate the correlations between number of choroidal abnormalities, Lisch nodules, and patient age. (dovepress.com)
  • One of the authors (SM) counted the total number of choroidal abnormalities in an area within a 55° angle centered on the fovea and of Lisch nodules on the iris by slit-lamp biomicroscopic examination under masking to other patient characteristics. (dovepress.com)
  • Ocular manifestations are very rare with Lisch nodules, plexiform neurofibroma, and optic pathway gliomas. (ijhas.in)
  • This is the first report of a home-based virtual-reality visual rehabilitation program for adult patients with hemianopia consecutive to a pediatric brain tumor. (frontiersin.org)
  • Brain tumor and its treatment can affect the visual system at different levels, from the optic nerves (through compression or infiltration), to subcortical structures like the superior colliculus (SC) and lateral geniculate nuclei (LGN) to optic tracts, optic radiations, and visual cortices ( 1 - 4 ). (frontiersin.org)
  • Here, we report, for the first time, the feasibility and potential effectiveness of a visual rehabilitation procedure consecutive to a pediatric brain tumor in two young adult patients with hemianopia. (frontiersin.org)
  • 8 Furthermore, stimulation of optic nerve activity increases optic glioma growth, while decreasing visual experience through light deprivation decreases tumor initiation and maintenance. (tamhsc.edu)
  • Genetic tests look at the unique genetic material (genes) of patients' tumor cells. (mayoclinic.org)
  • Selumetinib is a drug that works by blocking some enzymes that low grade glioma tumor cells need for their growth. (mayoclinic.org)
  • She went in to see a neurosurgeon who diagnosed her with a brain tumor known as optic nerve glioma, a cancer typically seen in children. (mdanderson.org)
  • Analysis of tumor samples of brain cancer patients with the IDH1 mutation revealed up to hundred-fold elevations in concentrations of 2HG, a metabolite that has been previously linked to the formation of brain cancer. (rdworldonline.com)
  • The purpose of this research study is to understand the natural history of vision in patients with OPG and determine if there are factors (e.g. age at diagnosis, male/female, tumor location, features of the MRI exam, etc) that predict future vision loss or change in tumor size. (mayo.edu)
  • In a cohort of 448 NF1 patients in the UK, the overall risk of cancer was increased 2.7-fold compared to the general population, and malignant peripheral nerve sheath tumor (MPNST) was the leading cause of death [ 8 ]. (biomedcentral.com)
  • The most common type of brain tumor is glioma. (cincinnatichildrens.org)
  • Combination therapy with sorafenib and celecoxib for pediatric patients with desmoid tumor. (dukecancerinstitute.org)
  • However, monocular vertical nystagmus in an infant with a relative afferent pupillary defect and optic nerve head atrophy suggests an optic nerve or chiasmal tumor (glioma) and therefore warrants neuroimaging. (aao.org)
  • Ryall S, Tabori U, Hawkins C. Pediatric low-grade glioma in the era of molecular diagnostics. (tamhsc.edu)
  • de Blank P, Bandopadhayay P, Haas-Kogan D, Fouladi M, Fangusaro J. Management of pediatric low-grade glioma. (tamhsc.edu)
  • The pupose of this study is to evaluate whether or not selumetinib works just as well as the standard treatment with carboplatine/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if selumetinib is better than CV in improving vision in subjects with LGG of the optic pathway (vision nerves). (mayoclinic.org)
  • It is not yet known whether selumetinib works better in treating patients with NF1-associated low-grade glioma compared to standard therapy with carboplatin and vincristine. (mayo.edu)
  • T1 weighted axial MRI after gadolinium reveals an enhancing mass at the base of the brain extending into the orbital optic nerves, midbrain, and medial left temporal lobe. (uab.edu)
  • The most common site of gliomas is the brain, but gliomas can also affect the spinal cord or any other part of the CNS, such as the optic nerves. (rdworldonline.com)
  • The pterional craniotomy is the standard craniotomy approach to suprasellar lesions because it allows good visualization of the optic nerves, chiasm, and surrounding structures. (medscape.com)
  • False-positive results can occur because of unilateral optic nerve enhancement or other unilateral disorders, such as optic meningioma, vascular lesions, neuritis, pseudotumor, and sarcoidosis. (medscape.com)
  • Two patients were initially misdiagnosed as optic neuritis, and one patient as atypical non-arteritic anterior ischemic optic neuropathy (NAION). (uzh.ch)
  • Optic neuritis is an inflammation of the optic nerve. (medlineplus.gov)
  • Optic gliomas are usually pilocytic astrocytomas. (uab.edu)
  • Lenalidomide Demonstrates Promising Activity in Paediatric Gliomas/Astrocytomas The immunomodulatory agent lenalidomide (Revlimid) appeared clinically active and tolerable in pilocytic astrocytomas and optic pathway gliomas in a cohort of paediatric patients who progressed following initial therapy, according to findings from a phase 2 trial published in the Journal of Clinical Oncology . (braintumourresearch.org)
  • The diagnosis may be made with a high degree of confidence when the lesion involves the optic chiasm and retrochiasmatic optic pathway. (medscape.com)
  • T1 weighted sagital MRI shows mass thickening the optic chiasm. (uab.edu)
  • This patient does have NF-I, but only about one fourth of patients with optic gliomas have NF-I. They commonly involve the optic chiasm and extend posteriorly to involve optic tracts and radiations, as in this case. (uab.edu)
  • A glioma originating in the optic nerve or optic chiasm. (nih.gov)
  • A subfrontal approach is appropriate for lesions that lie anterior to the optic chiasm, but this may be difficult to determine preoperatively. (medscape.com)
  • The drawback to this approach is the inability to identify the optic chiasm and pituitary stalk early in the dissection. (medscape.com)
  • The solid components often adhere to the optic chiasm or hypothalamus and, therefore, may be difficult to remove in their entirety. (medscape.com)
  • [ 9 , 10 ] Although MRI may reveal even subtle lesions of the optic nerve, CT scanning can detect a subtle erosion or expansion of the optic canal. (medscape.com)
  • To present and discuss 2 patients with acquired peripapillary pigmented lesions. (nih.gov)
  • Since all lesions in NF1 can convert from benign to malignant, MSI is an ideal technology to monitor NF1 patients. (retinarevealed.com)
  • Surgical treatment may be necessary in patients with extensive skin lesions. (medscape.com)
  • however, one patient required two biopsies for diagnosis. (uzh.ch)
  • PMA should be considered in the differential diagnosis of hypothalamic/chiasmal glioma. (aao.org)
  • The definitive diagnosis of NF1 in all patients is a strength of our study, and the high rate of death related to malignant transformation is consistent with previous work. (biomedcentral.com)
  • For the vast majority of patients, diagnosis can be made on clinical grounds, although improved blood testing for the gene defect is now available with high sensitivity and specificity. (medlink.com)
  • In some situations, imaging technology can help pinpoint a diagnosis and ultimately help the patient receive the best care. (reviewofoptometry.com)
  • The proper diagnosis of NF-1 is a crucial task for a clinician due to the various clinical manifestations including vision and life-threatening malignancies in few patients, which may arise in the different phases of life. (ijhas.in)
  • PNOC-022 (DMG-ACT): A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas including Diffuse Intrinsic Pontine Gliomas at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression. (anzchog.org)
  • In 2000, Yasunari et al 2 suggested that choroidal abnormalities were easily detectable by infrared light examination with a scanning laser ophthalmoscope in 100% of their NF1 patients. (dovepress.com)
  • Antiarrhythmic treatment may be required in patients with cardiac rhythm abnormalities. (medscape.com)
  • Owing to reported midline low-grade gliomas in the suprasellar region in 4 encephalocraniocutaneous lipomatosis (ECCL) patients, some authors also recommend ophthalmologic and endocrinologic control in order to quickly discover any warning signs. (medscape.com)
  • A low-grade form of this neoplasm, benign optic glioma, occurs most often in pediatric patients. (medscape.com)
  • PURPOSE Malignant optic glioma of adulthood is a rare, invasive neoplasm of the anterior visual pathway with 66 cases reported in the literature. (uzh.ch)
  • Freckling in the axillary and inguinal regions are another common presenting feature seen in as many as 90% of patients during childhood. (wikipedia.org)
  • Our patient was diagnosed, based on café-au-lait spots and axillary freckles. (j-epilepsy.org)
  • Currently there is only one MEK inhibitor, selumetinib, approved for pediatric patients who have this debilitating rare disease. (nfnetwork.org)
  • NSF/NFD was first identified in 1997 and although its cause remains unclear, appears to occur in patients with impaired renal function and acidosis. (medscape.com)
  • This phenomenon may occur in patients with poor vision from a variety of underlying etiologies, including optic neuropathy and amblyopia. (aao.org)
  • Our aim was to evaluate mortality in a large retrospective cohort of NF1 patients seen in France between 1980 and 2006. (biomedcentral.com)
  • A 1986 study in a Danish cohort of 212 patients diagnosed 42 years earlier showed excess mortality with an increase in malignancies in the males but not in the females, compared to the general population [ 5 ]. (biomedcentral.com)
  • A study of a national retrospective cohort of 1375 patients over 10 years. (cdc.gov)
  • Biomarker Testing in Older Patients Treated for an Advanced or Metastatic Non-Squamous Non-Small-Cell Lung Cancer: The French ESME Real-Life Multicenter Cohort Experience. (cdc.gov)
  • A novel NFAT1-IL6/JAK/STAT3 signalling pathway related nomogram predicts overall survival in gliomas In this study, researchers discovered that a protein known as NFAT1 (Nuclear factor of activated T cell-1) is expressed differently in various types of cancers and plays a crucial role in malignant progression in glioma patients through the IL6-JAK-STAT3 signalling pathway. (braintumourresearch.org)
  • This breakthrough discovery shows that the mutated form of IDH1 produces a metabolite, 2-hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas, the most common type of brain cancers. (rdworldonline.com)
  • Few disagree that many patients with childhood-onset GHD require continuous GH replacement therapy into adulthood. (medscape.com)
  • A neoplastic disease was suspected in the two remaining patients. (uzh.ch)
  • Group 4 includes other patients with progressing/refractory glioma with activation of the MAPK/ERK pathway. (biomedcentral.com)
  • Current research shows that the inactivation of neurofibromin in patients with NF-1 leads to the overactivation of the Ras/MAPK pathway and increased incidence of pediatric low-grade gliomas and optic gliomas. (tamhsc.edu)
  • Although data are relatively limited, studies have investigated the mechanisms of the disease progression in this patient population and found that pharmacological inhibition of the Ras/MAPK and/or mTOR signaling pathways are potential treatment options for NF1-pLGGs and optic gliomas. (tamhsc.edu)
  • Little is known, however, about the effect of chemotherapy on visual outcome of these patients. (prinsesmaximacentrum.nl)
  • DISCUSSION: Published studies on childhood low grade gliomas have not shown satisfactorily whether chemotherapy improves outcome of vision in children with OPG. (prinsesmaximacentrum.nl)
  • Little is known, however, about the effect of chemotherapy on visual outcome of these patients.MATERIAL AND METHODS: A systematic review of the literature was carried out to identify all studies published in PubMed, EMBASE and Cochrane Library between 1990 and 2008 reporting visual outcome in children with OPG after chemotherapy. (prinsesmaximacentrum.nl)
  • Moreover, cannabis has been used for centuries to treat various diseases, and today medicine confirms its effectiveness in treating the symptoms of glaucoma, stimulating appetite in AIDS patients and people undergoing chemotherapy, as well as in relieving pain in various patients. (stammering-stuttering.co.uk)
  • In scientific journals there is information that cannabis reduces vomiting reflexes and nausea in patients undergoing chemotherapy. (stammering-stuttering.co.uk)
  • Patients with growth hormone deficiency (GHD) typically have hyperlipidemia, increased body fat, premature atherosclerotic plaques, delayed bone maturation, and impaired cardiac function. (medscape.com)
  • In children, unenhanced CT scans typically reveal a marked, diffuse enlargement of the optic nerve, with characteristic kinking or bending. (medscape.com)
  • 3 Therefore, the choroid is one of the structures of the eye that is most commonly affected by NF1, and near-infrared reflectance is typically used to detect choroidal nodules in NF1 patients. (dovepress.com)
  • [2] Patients with hypothalamic PMA typically present with DS but develop ophthalmological findings (e.g., optic neuropathy) as the disease progresses. (aao.org)
  • In addition, fine calcification, which may help to identify a lesion as a meningioma rather than a glioma, is visualized best through CT scanning. (medscape.com)
  • CT scanning is the better modality for identifying uncommon meningioma with flecks of calcification, which are rare in optic nerve glioma. (medscape.com)
  • We have observed significant responses to trametinib in patients with refractory PLGG in our institutions and results from the phase I study are promising. (biomedcentral.com)
  • Group 1 includes NF1 patients with progressing/refractory glioma. (biomedcentral.com)
  • Group 3 includes patients with progressing/refractory glioma with KIAA1549-BRAF fusion. (biomedcentral.com)
  • 4 Although prognosis of pLGGs is generally positive with overall 10-year survival rates between 85-96%, survivors of these gliomas often suffer from neurologic, endocrine, and functional complications from the treatment or the cancer itself. (tamhsc.edu)
  • Collaborate with an interprofessional team on strategies for improving care coordination and communication to improve outcomes for affected patients. (nih.gov)
  • [1] Among the major differences between JPA and PMA is the age of patients and outcomes. (aao.org)
  • Clinical outcomes of lung adenocarcinoma patients harboring uncommon epidermal growth factor receptor (EGFR) mutations treated with EGFR-tyrosine kinase inhibitors (TKIs). (cdc.gov)
  • On the basis of these factors, we calculated a combined risk score for neurologic deficits for each patient. (ajnr.org)
  • The first patient was diagnosed with a pigmented papillary lesion that was followed up for 38 years. (nih.gov)
  • 7 A separate study investigating NF-1 associated gliomas using a mouse model concluded that genetic loss or pharmacological inhibition of neuroligin 3 (NLGN3) shedding within the optic nerve impedes the progression of NF1 optic gliomas. (tamhsc.edu)
  • Favorable response to nivolumab in a young adult patient with metastatic histiocytic sarcoma. (dukecancerinstitute.org)
  • [4] Ophthalmologists encounter JPA in gliomas of the optic pathway and hypothalamus. (aao.org)
  • We reviewed the patients' clinical records and histopathologic findings. (nih.gov)
  • This is a retrospective record based on a clinical analysis of 25 cases of patients who presented to the eye outpatient department with unilateral proptosis during a period of 3 years. (hindawi.com)
  • They concluded that this individualised model can be used to predict the OS rate of patients with glioma at 1, 2, 3, 5 and 10 years and could offer practical clinical decisions for personalised treatment of glioma patients, to a certain extent. (braintumourresearch.org)
  • Clinical signs that help to identify patients who require imaging include: resistance to forced duction, diplopia, afferent pupillary defect, bony displacement of the orbital globe, orbital crepitus, enophthalmos and subconjunctival hemorrhage, which can indicate a retrobulbar hemorrhage. (reviewofoptometry.com)
  • One clinical caveat is when a patient suffers orbital trauma and presents with significant ecchymosis but with full range of motion and no evidence of globe displacement. (reviewofoptometry.com)
  • Therefore, the clinician and the clinical researcher must examine published data critically and must educate individual patients and their families about the risk-benefit ratio of rhGH therapy for them. (medscape.com)
  • MAIN OUTCOME MEASURES: Comparison of aggregated clinical features in patients with or without a SPRED1 or NF1 mutation. (duke.edu)
  • Antiepileptic treatment is administered in patients with clinical epileptic episodes. (medscape.com)
  • However, 100% of NSF/NFD cases reviewed thus far (75 of approximately 215 cases worldwide) have occurred in patients who had received a gadolinium-based contrast agent for MRI or MRA. (medscape.com)
  • However, approximately one-half of patients with this condition have no family history and the mutation occurs spontaneously. (wikipedia.org)
  • Moreover, approximately 15% of children with NF1 develop low-grade optic gliomas. (tamhsc.edu)
  • 2] Approximately 70 percent of gliomas are known to have the IDH1 mutation. (rdworldonline.com)
  • Scope and Contents Typed case summary, notes, reports, photographs and correspondence relating to female patient from Edinburgh and the Lothians aged 20 at first examination in 1934. (ed.ac.uk)
  • Scope and Contents Typed case summary and correspondence relating to male patient from Great Britain (excluding Scotland) aged 17 at first examination in 1941. (ed.ac.uk)
  • Scope and Contents Typed case summary, charts and correspondence relating to female patient from Scotland (outside Edinburgh and the Lothians) aged 52 at first examination in 1941. (ed.ac.uk)
  • Ophthalmologic fundus examination may reveal papilledema or optic nerve pallor. (medscape.com)
  • In this case series, we sought to characterize the feasibility and potential effectiveness of a home-based visual rehabilitation program in hemianopia patients using immersive virtual-reality stimulation. (frontiersin.org)
  • Patients used a virtual-reality, stand-alone, and remotely controlled device loaded with a non-commercial audiovisual stimulation program managed in real time from the laboratory. (frontiersin.org)
  • The interaction of neurofibromin and SPRED1 was described comprehensively, providing functional insight that will help in the interpretation of pathogenicity of certain missense variants identified in NF1 and Legius syndrome patients. (escholarship.org)
  • The mutations are located in chromosome 17q11.2, which codes for neurofibromin (NF1) and detected in about 95% of patients. (j-epilepsy.org)