• Background: This cross-sectional study aims to investigate the correlation between obstructive sleep apnea syndrome (OSAS) risk with periodontal disease and anthropometric measures in Class III obese patients. (unesp.br)
  • 0.001) were significantly larger in the patients at high risk for OSAS than in those at low risk for OSAS. (unesp.br)
  • Conclusion: There was no association between periodontal disease and OSAS risk in Class III obese patients, but OSAS risk was associated with both NC and PPNC. (unesp.br)
  • Obstructive sleep apnea syndrome (OSAS) is a highly prevalent, but underdiagnosed disorder. (mhmedical.com)
  • A diagnosis of OSAS is based on the finding of significant respiratory disturbance due to collapse of the upper airway during sleep in the setting of compatible daytime symptomatology. (mhmedical.com)
  • The gold standard for diagnosis of OSAS is the performance of inpatient nocturnal polysomnography (PSG), which provides detailed information on respiration, sleep staging and quality, and a range of other variables including heart rate and rhythm. (mhmedical.com)
  • Unfortunately, PSG is both resource intensive and time consuming for the patient, and a growing research interest lies in the development and validation of technologies facilitating the ambulatory investigation of subjects with suspected OSAS, but the utility of these methods requires confirmation in large-scale clinical outcome studies. (mhmedical.com)
  • The prevalence of obstructive sleep apnea syndrome (OSAS) in the general population is considerably high. (unimore.it)
  • While the bulk of published studies focus on OSAS in patients with an elevated body mass index (BMI), few have investigated the anatomical and pathophysiologic implications of OSAS in patients with normal body weight. (unimore.it)
  • In a previous study, the authors found that among these patients the primary anatomic anomaly contributing to the onset of OSAS was hypertrophy of the base of tongue, while septal deviation was a concurrent cause of the syndrome. (unimore.it)
  • With this review the authors describe the anatomic, functional, clinical and therapeutic aspects of OSAS in patients with normal body weight. (unimore.it)
  • Objectives: Obstructive sleep apnoea syndrome (OSAS) is a growing health concern as it is associated with serious comorbidities. (elsevierpure.com)
  • OSAS is mainly related to obesity, age, gender and a narrowed upper airway is commonly seen in patients with OSAS. (elsevierpure.com)
  • This study aimed to compare spirometry parameters between obese OSAS patients and non-obese OSAS patients when patients moved from sitting to supine. (elsevierpure.com)
  • Patients with severe OSAS and who were OSAS treatment naïve were recruited. (elsevierpure.com)
  • Results: A total of 27 OSAS patients (19 males and 8 females) were included in this study. (elsevierpure.com)
  • Male patients with OSAS had reduced FVC compared to females. (elsevierpure.com)
  • Conclusion: A supine position may cause lower airway obstruction in obese patients with OSAS. (elsevierpure.com)
  • We examined the presence of the Obstructive Sleep Apnea Syndrome (OSAS) and explored associations/correlations between sleep variables, anthropometric measures, cognitive performance, and psychological distress in severely obese patients. (scholink.org)
  • The incidence of the OSAS is higher in severely obese patients. (scholink.org)
  • Obstructive sleep apnea syndrome (OSAS) is a complete or partial airway obstruction that can cause significant physiologic disturbance with various clinical impacts. (nih.gov)
  • To evaluate the prevalence and clinical performance of obstructive sleep apnoea syndrome (OSAS) in acromegalic patients, focusing on the possible correlation between alterations of pulmonary microcirculation and patient's clinical and hormonal parameters. (scirp.org)
  • OSAS is a highly prevalent sleep disorder characterized by a transient cessation in breathing (apnea) or a significant reduction in breathing amplitude (hypopnea), due to recurrent episodes of upper airway obstruction and subsequent recurrent arousal during sleep. (scirp.org)
  • Adenotonsillectomy may be indicated for obstructive sleep apnea syndrome (OSAS). (medscape.com)
  • Weight loss is recommended for patients with obesity and OSAS. (medscape.com)
  • Polysomnography-based diagnosis in Mexican adult patients with Obstructive Sleep Apnea Syndrome (OSAS) clinical suspicion. (nel.edu)
  • Arrazola-Cortés E, Hernández-Cervantes J, González-Pérez B, Sauri-Suárez S, López-Hernández L, Toledo-Lozano C, Orellana-Villazón V, Alcaraz-Estrada S, García S. Polysomnography-based diagnosis in Mexican adult patients with Obstructive Sleep Apnea Syndrome (OSAS) clinical suspicion. (nel.edu)
  • Obstructive sleep apnea syndrome (OSAS) is well known to be a highly prevalent sleep disorder. (acc.org)
  • Multiple epidemiological studies have found links between OSAS and metabolic syndrome. (acc.org)
  • reported that fasting glucose and insulin levels were significantly higher in OSAS patients compared to weight matched controls. (acc.org)
  • They also found that OSAS led to systemic inflammation and metabolic syndrome. (acc.org)
  • After adjusting for age, body mass index (BMI), and smoking, OSAS patients were found to be nearly six times more likely to have metabolic syndrome than controls. (acc.org)
  • Recently, a number of observational and case control studies have shown associations between OSAS, metabolic syndrome and procoagualant states. (acc.org)
  • Children with obstructive apnea-hypopnea index (OAHI) ≥ 1 were defined as OSAS. (biomedcentral.com)
  • Obstructive sleep apnea syndrome (OSAS) is a common condition in children. (biomedcentral.com)
  • Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction that occur during sleep which leads to cardiovascular, neurovascular and metabolic diseases. (uwi.edu)
  • In this report, we aimed to determine the cause of oxidative imbalance in patients with OSAS and to evaluate the vascular endothelial dysfunction as a suspect for complications of the disease. (uwi.edu)
  • Sleep-disordered breathing is defined as an apnea-hypopnea index (AHI) of greater than five events per hour as measured by PSG, and can be further classified as mild (AHI 5-15 events per hour), moderate (AHI 15-30 events per hour), or severe (AHI >30 events per hour). (mhmedical.com)
  • We hypothesized that positional therapy would be equivalent to continuous positive airway pressure (CPAP) at normalizing the apnea-hypopnea index (AHI) in patients with positional obstructive sleep apnea (OSA). (researchgate.net)
  • We enrolled 22 acromegalic patients with apnea hypopnea index (AHI) ≥ 5 if symptomatic, or ≥15 in the absence of sleep related symptoms. (scirp.org)
  • It was also seen that moderate OSA with an apnea-hypopnea index (AHI) where they take more than 15 breathing pauses per hour of sleep were apparently seen in about 88 percent of the subjects. (healthjockey.com)
  • The name of the trial is "Follow-up Studies of Primary Snoring (PS) and Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) in Chinese Children" and the URL is https://clinicaltrials.gov/ . (biomedcentral.com)
  • To do this in a safe manner requires careful attention and alertness which can be problematic for patients with obstructive sleep apnoea/hypopnoea syndrome (OSAHS) or other sleep disorders. (bmj.com)
  • He is a Consultant and Specialist Orthodontist with over 30 years clinical experience, with a special interest in sleep related breathing disorders, TMJD, and bruxism. (somnowell.com)
  • In recent years, there has been mounting interest in respiratory disorders during sleep in patients with acromegaly. (scirp.org)
  • Nocturnal breathing disorders affect the majority of patients with acromegaly. (scirp.org)
  • The effectiveness of CBT for childhood sleep disorders has been well demonstrated in controlled studies and clinical case reports. (medscape.com)
  • Pharmacologic treatments of sleep disorders are not supported by adequate and significant empiric data. (medscape.com)
  • Because of the paucity of adequate empirical studies, pharmacotherapy data are limited to treatment in select sleep disorders. (medscape.com)
  • In addition, potential complications of sleep disorders, such as hypertension from obstructive SA, may also be discovered. (medscape.com)
  • Because of the variability of the presentation of the disorder, any or all symptoms of insomnia or other sleep disorders may manifest, depending on the presenting subtype. (medscape.com)
  • The AADSM Annual Meeting will bring together almost 700 international clinical and research leaders in dental sleep medicine to present and discuss new findings and developments related to sleep-related breathing disorders. (scienceblog.com)
  • Its aim is to investigate the causes and consequences of sleep-related breathing disorders and translate research into improvements in patient care. (wiley.com)
  • One hundred and eighty adults answered the ESS, including 30 normal men and women as controls and 150 patients with a range of sleep disorders. (nih.gov)
  • Metabolic syndrome is one of the most common disorders in industrialized countries. (druglib.com)
  • The questionnaire included demographic data and information related to potential risk factors for sleep disorders. (biomedcentral.com)
  • According to the National Commission on Sleep Disorders Research, at least 40 million Americans suffer from chronic sleep disorders, and another 20 to 30 million experience occasional sleep problems. (mercy.net)
  • If your physician suspects you may have a sleep disorder, he or she may recommend you undergo a sleep study at our state-of-the-art sleep disorders center. (mercy.net)
  • Mercy Sleep Disorders Center in Berryville, AR is Gold Standard AASM Accredited, offering state-of-the-art technology. (mercy.net)
  • Our sleep center staff routinely see patients for a variety of sleep disorders including obstructive sleep apnea, excessive daytime sleepiness, insomnia, narcolepsy and restless leg syndrome. (mercy.net)
  • Prevalence of obstructive sleep apnoea in acute coronary syndrome patients: systematic review and meta-analysis. (edu.au)
  • Hence the high levels of aldosterone are seen with the prevalence of metabolic syndrome and can be a very good predictor of the onset of hypertension. (somnowell.com)
  • Tthe prevalence of metabolic syndrome is higher in OSAHS patients than in the general population even though the biological mechanisms underlying this association between OSAHS and MS are not yet fully understood. (somnowell.com)
  • Clinical Genomics: Practical Applications in Adult Patient Care, 1e Murray MF, Babyatsky MW, Giovanni MA, Alkuraya FS, Stewart DR. Murray M.F., & Babyatsky M.W., & Giovanni M.A., & Alkuraya F.S., & Stewart D.R.(Eds. (mhmedical.com)
  • In two more patients, with an EP300 variant, abnormal neural tube development, a rare clinical finding, occurred. (medscape.com)
  • Empty nose syndrome (ENS) is a clinical syndrome, the hallmark symptom of which is a sensation of suffocation despite a clear airway. (wikipedia.org)
  • The etiology is multifactorial and its clinical manifestations are night snoring, headache when patient wakes up, day-time sleepiness and degrease of cognitive performance. (nih.gov)
  • Treatment of obstructive sleep apnoea (OSA) in adults is evolving, as new therapies have been explored and introduced in clinical practice, while other approaches have been refined or reconsidered. (researchgate.net)
  • A multidisciplinary group of experts, including pulmonary, surgical, dentistry and ear-nose-throat specialists, methodologists and patient representatives considered the most relevant clinical questions (for both clinicians and patients) relating to the management of OSA. (researchgate.net)
  • Clinical research of all other sleep problems and in other age ranges is still very limited. (medscape.com)
  • This study was published in the Journal of Clinical Sleep Medicine (JCSM). (healthjockey.com)
  • Other experts say clinical lycanthropy may involve a culture-bound syndrome, which is a mental illness or unusual behaviors shaped by cultural norms or surroundings. (webmd.com)
  • Following a Fellowship at the University of Wisconsin-Madison, USA, she returned to the UK to set up the Unit of Sleep and Breathing with clinical colleagues at Royal Brompton Hospital, London. (wiley.com)
  • Patients have a variety of clinical findings that include postnatal growth failure, delayed psychomotor development, dysmorphic features, and hypotonia. (hindawi.com)
  • The final study referred to as "office hypertension" or "iso- group was 2462 patients for whom ABPM lated clinical hypertension") is generally data were accepted for further analysis. (who.int)
  • Clinical presentation and genetic variants in patients with autoinflammatory diseases: results from the German GARROD registry. (cdc.gov)
  • Patients with PFO-related DS tend to have early occurrence of symptoms after surfacing and a clinical presentation that indicates brain or upper cervical spinal cord involvement. (who.int)
  • Find out if you may be suitable for the Somnowell device for snoring and sleep apnoea. (somnowell.com)
  • Prof. Ash is the inventor of the highly successful SOMNOWELL Chrome device for snoring and sleep apnoea. (somnowell.com)
  • He currently works in Harley Street London and two private hospitals in London as part of a multi-disciplinary team managing snoring and sleep apnoea, and is Visiting Professor of Orthodontics at the BPP University. (somnowell.com)
  • This syndrome is characterized by daytime sleepiness, non-restorative sleep, fatigue, insomnia, loud snoring, witnessed breathing interruptions, morning headaches, and recurrent awakenings due to gasping or choking in the presence of at least five obstructive respiratory events (apneas, hypopneas, or respiratory effort-related arousals) per hour of sleep. (scirp.org)
  • SDB includes obstructive sleep apnea (OSA), upper-airway resistance syndrome, and snoring. (scienceblog.com)
  • He was assisted by Dr. Tapan Padhya, chief of the TGH ENT Institute, professor, chair and chief, Division of Head and Neck Oncology, professor and chair of the Department of Otolaryngology-Head & Neck Surgery, USF Health Morsani College of Medicine, and founder and co-director of the USF Health ENT Sleep and Snoring Center. (tgh.org)
  • Snoring is simply a case of air moving over the relaxed tissues of the throat, causing those tissues to vibrate during sleeping. (marksdailyapple.com)
  • Sleep apnea, however, takes snoring to a whole new level, with a physical closing of the airway along with the usual snoring. (marksdailyapple.com)
  • Sure, snoring can be a symptom of sleep apnea, but most people who snore don't actually suffer from apnea itself. (marksdailyapple.com)
  • Research shows that snoring can exact a serious physical toll, even when it's not classified as sleep apnea. (marksdailyapple.com)
  • Children between 2 and 15 years of age exhibiting snoring symptoms who visited the sleep center for polysomnography (PSG) were enrolled. (biomedcentral.com)
  • scholarship on "Effects of snoring and obstructive sleep apneas on attention and supervision and on the cardiovascular system" delivered by the Consortium for the management of the clinic for nervous and mental diseases, University of Bologna. (unibo.it)
  • Snoring is part of the spectrum of sleep disordered breathing. (scirp.org)
  • The patients with snoring should be evaluated for nasal airway obstruction. (scirp.org)
  • In this study, the upper air way tract was characterized in snoring patients and compared with none snoring using a quantify method for the corresponding anatomic upper air way (UA) parameters examined by Computerized Tomography (CT). (scirp.org)
  • Two hundred Asian patients undergoing CT scanning for head and neck were included and were divided into two groups (snoring group [n = 127] and non-snoring group [n = 73]) (mean age: 44.8 ± 15.9 years and 26.2 ± 7.0). (scirp.org)
  • UA CT quantitative features play an important role in the characterization of the anatomy and are compared between snoring patients and non-snoring subjects. (scirp.org)
  • There have been no sufficient studies to delineate the relationship that exists between obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and metabolic syndrome. (somnowell.com)
  • Patients with OSAHS, those with and without metabolic syndrome, were tested for plasma aldosterone concentrations (PAC) and plasma aldosterone: renin activity (PRA) ratio. (somnowell.com)
  • The evaluation was repeated for all the OSAHS patients after a period of 12 months in which effective treatment with continuous positive airway pressure (CPAP) was undertaken. (somnowell.com)
  • The aldosterone levels are also associated with presence of metabolic syndrome and it aggravates or predisposes metabolic and cardiovascular complication brought about OSAHS. (somnowell.com)
  • Patients with OSAHS and metabolic syndrome had higher levels of glucose than patients without MS. (somnowell.com)
  • Objective: To report the case of a patient with moderate OSAHS. (bvsalud.org)
  • Final considerations: The treatment was effective in improving pain symptoms, clearing the air passage, allowing better ventilation of the patient and controlling the side effects and secondary OSAHS in bucofaciais structures. (bvsalud.org)
  • and between aldosterone and metabolic syndrome. (somnowell.com)
  • To find out if hyperaldosteronism is more prevalent in obstructive sleep apnoea-hypopnoea syndrome patients and is associated with metabolic syndrome, a study was set up. (somnowell.com)
  • Patients with metabolic syndrome were used as the controls. (somnowell.com)
  • 33 of the patients had metabolic syndrome while the other 33 did not have metabolic syndrome. (somnowell.com)
  • 1 Metabolic syndrome constitutes a collection of interrelated risk factors of metabolic origin that increase the chances of developing heart disease, stroke, and diabetes. (acc.org)
  • As with OSA, a number of case control studies have been published exploring the potential association between the metabolic syndrome and VTE. (acc.org)
  • compared the incidence of metabolic syndrome in a group of 93 patients with a first episode of unprovoked DVT and in 107 controls.9 They found metabolic syndrome to be significantly more prevalent in patients with unprovoked DVT than in controls, with an adjusted odds ratio of 2.16 [95% confidence interval (CI) 1.19- 3.90]. (acc.org)
  • Contrary to the above findings, in a post hoc analysis of the Heart Outcomes Prevention Evaluation (HOPE) study, the presence of metabolic syndrome was not found to be associated with an increased risk of VTE. (acc.org)
  • 13 However, this conclusion has been criticized since the authors measured only four of the five features of the metabolic syndrome, and the cut-offs used for defining hypertension, dyslipidemia, and insulin resistance were different from those commonly proposed for diagnosis of this entity. (acc.org)
  • Metabolic syndrome consists of a group of co-occuring conditions that increase an individual's risk of developing heart disease, stroke, and diabetes. (druglib.com)
  • The purpose of this study is to evaluate the long-term effectiveness of chloroquine, a protein-activation medication, at reducing the progression of atherosclerosis in patients with the metabolic syndrome. (druglib.com)
  • In animals, activation of the protein ataxia telangiectasia mutated (ATM) using the antimalarial drug chloroquine improves features of metabolic syndrome and decreases atherosclerosis, a build-up of fatty plaque within arteries. (druglib.com)
  • The purpose of this study is to examine the effect of long-term treatment with low doses of chloroquine on atherosclerosis in people with metabolic syndrome. (druglib.com)
  • She has been the primary investigator in several research studies and has published on a variety of topics including obstructive sleep apnea, metabolic syndrome and care of the cardiovascular patient. (mayoclinic.org)
  • Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. (bvsalud.org)
  • and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation? (bvsalud.org)
  • Obstructive sleep apnea is a prevalent condition wherein the upper airway becomes blocked repeatedly during sleep, leading to disrupted airflow due to muscle relaxation around the tongue and throat. (tgh.org)
  • Diagnosis of OSA should be confirmed with multichannel sleep studies. (bmj.com)
  • The patients were studied at diagnosis and after effective treatment. (somnowell.com)
  • We observed a positive correlation between GH level at diagnosis and DLCO value, showing that acromegalic patients have an increase in static and dynamic respiratory volumes and alveolar-capillary exchange surface compared to the general population. (scirp.org)
  • Diagnosis is based on sleep history and polysomnography. (msdmanuals.com)
  • Recognition and diagnosis of obstructive sleep apnea in older Americans. (msdmanuals.com)
  • 1, 2 Sleepiness can lead to increased inattention and, not surprisingly, performance is often diminished in sleepy patients. (bmj.com)
  • Sleepiness has both homeostatic and circadian influences with the latter increasing sleep propensity at certain times of the day. (bmj.com)
  • Recurrent collapse of the upper airway during sleep causes repetitive episodes of intermittent hypoxia, and recurrent arousals from sleep, leading to daytime sleepiness, poor quality of life, and increased risk of road traffic accidents, cardiovascular morbidity and mortality, and metabolic dysfunction. (mhmedical.com)
  • A 2023 study found that ENS patients scored significantly higher on the Epworth Sleepiness Scale than control groups, and that severity of ENS symptoms correlated with severity of sleepiness. (wikipedia.org)
  • It is characterized by repeated disruptions of breathing during sleep leading to excessive daytime sleepiness, neurocognitive deterioration, endocrinologic and metabolic effects, and overall decreased quality of life. (acc.org)
  • However they may not be noticed as complications of untreated OSA may result in problems like cardiovascular disease, daytime sleepiness and impaired cognitive functioning may overlap with the appearance of Down syndrome. (healthjockey.com)
  • Most people who suffer from sleep apnea apparently snore loudly and daytime sleepiness is commonly experienced by them. (healthjockey.com)
  • Modafinil is used to treat excessive sleepiness caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours in people who work at night or on rotating shifts). (medlineplus.gov)
  • Modafinil may decrease your sleepiness, but it will not cure your sleep disorder. (medlineplus.gov)
  • Patients with RSTS are susceptible to frequent infections (pulmonary and otitis media), have a high anesthesia risk, demonstrate an ineffective response to vaccines (polysaccharide), and have dental abnormalities. (medscape.com)
  • None of the participants suffered from any chronic disease such as diabetes, chronic obstructive pulmonary disease (COPD), liver cirrhosis, thyroid dysfunction, rheumatoid arthritis, chronic renal failure. (somnowell.com)
  • Patients underwent the following evaluations: GH and IGF-1 serum levels, arterial blood gas test, spirometry, carbon monoxide diffusing capacity (DLCO), home-based cardiorespiratory sleep and pulmonary function test. (scirp.org)
  • The aim of the present study was to compare the evolution of pulmonary haemodynamics and of arterial blood gases in chronic obstructive pulmonary disease (COPD) patients with mild-to-moderate hypoxaemia, with or without sleep-related oxygen desaturation. (ersjournals.com)
  • At baseline ( t 0 ), patients with sleep-related desaturation had a significantly higher daytime (mean±sd) arterial carbon dioxide partial pressure ( P a,CO 2 ) (44.9±4.9 mmHg versus 41.0±4.1 mmHg, p=0.001) whereas mean pulmonary artery pressure (mPAP) was similar in the two groups. (ersjournals.com)
  • Chronic Obstructive Pulmonary Disease is a group of conditions that blocks airflow and makes normal breathing difficult. (ucsd.edu)
  • Weight loss is a clinically important risk factor indicating a poor prognosis in chronic obstructive pulmonary disease (COPD). (karger.com)
  • Median AHI of 16 was seen in the controls that had less severe sleep apnea. (healthjockey.com)
  • They must be between 12 and 18 years of age, have moderate to severe sleep apnea and be intolerant of a CPAP device. (tgh.org)
  • The epidemiologically most important factor is obesity, since increased adipose tissue leads to alterations in upper airway anatomy and function that can trigger the mechanisms underlying the syndrome. (unimore.it)
  • Sixty-one patients who required treatment for severe obesity performed a neuropsychological evaluation and an overnight polysomnography. (scholink.org)
  • Physical examination and the Mental Status Examination may give clues to the causes of sleep disturbance (eg, obesity with resulting obstructive sleep apnea [SA], depression). (medscape.com)
  • The author proposes that obesity which is a general and impending treatable problem in Down syndrome appears to play a significant function in the pathophysiology of OSA in this population. (healthjockey.com)
  • The most common cause of actual obstructive sleep apnea is excess weight and obesity. (marksdailyapple.com)
  • Evaluation of sleep disorder in elderly patients begins with a complete sleep history. (medscape.com)
  • These data help determine the sleep pattern of the patient, the severity of the disorder, and the possible causes leading to sleep disturbances. (medscape.com)
  • American Academy of Sleep Medicine shares that OSA is a breathing disorder which is sleep related. (healthjockey.com)
  • a sleep disorder in which the patient briefly stops breathing or breathes shallowly many times during sleep and therefore doesn't get enough restful sleep). (medlineplus.gov)
  • If you are taking modafinil to treat shift work sleep disorder, you will probably take it 1 hour before the beginning of your work shift. (medlineplus.gov)
  • A study linking the disorder with obstructive sleep apnea concluded that doctors should look for underlying neurologic issues in those with lycanthropy symptoms. (webmd.com)
  • Obstructive sleep apnea (OSA) is a common disorder that is associated with significant morbidity. (cdc.gov)
  • Ogden syndrome (MIM #300855) is a rare X-linked neurodevelopmental disorder caused by pathogenic variants of the NAA10 gene located at Xq28 [ 1 ]. (hindawi.com)
  • This categorization of NAA10 -related syndrome also includes Lenz microphthalmia syndrome (MIM#309800), a disorder also caused by pathogenic variants in the NAA10 gene which is characterized by abnormalities of the skeletal and urinary systems, teeth, ears, digits, and several ocular defects that may include unilateral or bilateral microphthalmia/anophthalmia, cataracts, nystagmus, coloboma, and glaucoma [ 3 ]. (hindawi.com)
  • More than half of children with the genetic disorder Down syndrome have sleep apnea," Padhya said. (tgh.org)
  • The syndrome substantially increases the risk of developing diabetes and vascular disease, but there is no clear unifying approach to treat this disorder. (druglib.com)
  • Preliminary findings support that combining 1 to 3 g per day of l-tryptophan and early-morning bright light exposure is more efficacious than either treatment alone in patients diagnosed with seasonal affective disorder. (psychologytoday.com)
  • Patients diagnosed with generalized anxiety disorder randomized to 5-HTP with carbidopa versus clomipramine reported equivalent and significant reductions in generalized anxiety. (psychologytoday.com)
  • Our respiratory therapists and pulmonologists offer a weekly airway clinic at UC San Diego Health to help those living with obstructive lung disease. (ucsd.edu)
  • It happens when during our sleep, muscles loosen up and due to which the soft tissues in the back of the throat give way and obstruct the upper airway. (healthjockey.com)
  • Only 59% of treated patients reported good adherence to treatment with positive airway pressure, and response to treatment correlated with OSA severity. (cdc.gov)
  • The most common treatment for OSA, positive airway pressure (PAP) treatment, is frequently initiated to reduce sleep-related symptoms. (cdc.gov)
  • The Inspire device is the only implant the U.S. Food and Drug Administration (FDA) has approved to treat sleep apnea and it is one of the few alternatives to using a continuous positive airway pressure (CPAP) machine. (tgh.org)
  • The open airway eliminates the struggle to breathe that characterizes sleep apnea, and patients can experience more restful sleep. (tgh.org)
  • In normal individuals upper airway narrowing increases the resistance to airflow at sleep onset. (scirp.org)
  • Obstructive sleep apnea involves a compromise in upper airway anatomy during sleep. (msdmanuals.com)
  • Sleep destabilizes patency of the upper airway, leading to partial or complete obstruction of the nasopharynx, oropharynx, or both. (msdmanuals.com)
  • Airway patency tends to oscillate causing recurrent periods of apnea and recovery. (msdmanuals.com)
  • Total ESS scores significantly distinguished normal subjects from patients in various diagnostic groups including obstructive sleep apnea syndrome, narcolepsy and idiopathic hypersomnia. (nih.gov)
  • Case reports suggest that nighttime use of 5-HTP at 300 to 600 mg may improve mild to moderate insomnia and lessen sleep disturbances related to obstructive sleep apnea and narcolepsy. (psychologytoday.com)
  • Anthropometric measures, cognitive performance, and psychological distress symptoms are influenced by sleep parameters and sleep efficiency. (scholink.org)
  • ENS patients may experience a range of symptoms. (wikipedia.org)
  • Understanding why some patients exhibit ENS symptoms while others do not and incorrectly attributing symptoms to psychological causes such as anxiety are common reasons ENS patients do not receive care. (wikipedia.org)
  • excessive citations] The major symptoms of ENS include a sensation of suffocation, nasal dryness, nasal burning, nasal crusting, and an impaired sense of airflow through the nose in patients who have had surgery or injury to nasal turbinates. (wikipedia.org)
  • Sleep apnea was found to correlate with severity of ENS symptoms and high BMI in a 2022 study. (wikipedia.org)
  • This change in airflow leads to an imbalance of CO2/O2 levels[citation needed] in the body, which will show hyperventilation-like symptoms in patients. (wikipedia.org)
  • Questions on the OSA 18 were divided into five domains: sleep disturbance, physical symptoms, emotional symptoms, daytime functions and caregiver concerns. (scienceblog.com)
  • Patients with more sleep-related symptoms appear to receive greater benefit from treatment than do patients with fewer sleep-related symptoms (10). (cdc.gov)
  • While causality is yet to be firmly established, there appears to be evidence indicating an intricate interplay between sleep cycles, arousal mechanisms, and acute thrombosis. (acc.org)
  • The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. (bvsalud.org)
  • Of the patients reporting good adherence, a greater proportion of those with severe OSA (27%) than with mild or moderate disease (0%-12%) reported an excellent response to treatment. (cdc.gov)
  • So just as an overview, some-- one very large study of cases in China reported that the vast majority of patients with COVID-19 do in fact have mild to moderate illness, however, 19% had severe or critical illness. (cdc.gov)
  • We speculate that the type and severity of ocular defects present in individuals with the NAA10 -related syndrome are dependent on the specific NAA10 pathogenic variant involved. (hindawi.com)
  • Patients were randomly assigned to a night with a positional device (PD) and a night on CPAP (10 +/- 3 cm H2O). (researchgate.net)
  • The total sleep time was unchanged with the PD, but decreased with CPAP, from 338 (303-374, 159-449) minutes to 334 (287-366, 194-397) and 319 (266-343, 170-386) minutes, respectively (p = 0.02). (researchgate.net)
  • Positional therapy is equivalent to CPAP at normalizing the AHI in patients with positional OSA, with similar effects on sleep quality and nocturnal oxygenation. (researchgate.net)
  • The most common treatment for overlap syndrome is non-invasive positive pressure ventilation therapies (such as CPAP and BIPAP) and in some patients, oxygen therapy during sleep. (ucsd.edu)
  • Despite the availability of numerous types of masks and interfaces, CPAP is often poorly tolerated, and it is difficult to predict which patients will adhere and respond to treatment (11). (cdc.gov)
  • It is difficult for young patients with Down syndrome to lose weight and typically these patients can't tolerate CPAP machines due to discomfort and an inability to understand why the machine is necessary and how it works. (tgh.org)
  • While ENS is physical in its origin, many ENS patients also struggle with depression, anxiety, and sleep disturbances. (wikipedia.org)
  • Propofol-based sedation has been widely used for gastroscopy, but the risk of respiratory suppression in elderly patients should not be overlooked. (dovepress.com)
  • Mary Morrell (right) is Professor of Sleep and Respiratory Physiology in the National Heart & Lung Institute at Imperial College London, UK. (wiley.com)
  • In patients with obstructive sleep apnea syndrome ESS scores were significantly correlated with the respiratory disturbance index and the minimum SaO2 recorded overnight. (nih.gov)
  • A recent study demonstrated that in patients with hypertension, plasma aldosterone levels were higher in the group with MS in spite of no differences in plasma renin activity between the groups with or without MS. (somnowell.com)
  • A total of 2462 patients underwent ambulatory blood pressure monitoring either in borderline hypertension (group 1) or for assessment of antihypertensive treatment (group 2) or for hypotension (group 3). (who.int)
  • Au total, 2 462 sujets ont fait l'objet d'une mesure ambulatoire de la pression artérielle, en raison d'une hypertension légère (groupe 1), aux fins de l'évaluation d'un traitement antihypertenseur (groupe 2), ou en raison d'une hypotension (groupe 3). (who.int)
  • Untreated patients are at risk for hypertension, atrial fibrillation and other arrhythmias, heart failure, and injury or death due to motor vehicle crashes and other accidents resulting from hypersomnolence. (msdmanuals.com)
  • Vertebral Tortuosity Is Associated With Increased Rate of Cardiovascular Events in Vascular Ehlers-Danlos Syndrome. (cdc.gov)
  • In rare cases, the disease is associated with excessive production of GH-releasing hormone (GHRH), familial syndromes, including multiple endocrine neoplasia type 1, McCune-Albright syndrome, familial acromegaly, and Carney's syndrome. (scirp.org)
  • In addition to facial structure differences, excessive weight in patients with Down syndrome often contributes to sleep apnea. (tgh.org)
  • OBJECTIVES: In any treated hypertensive patient office blood pressure (BP) values may differ between visits and this variability (V) has an adverse prognostic impact. (bvsalud.org)
  • l-Tryptophan, 1 g, at bedtime reduces time to sleep onset in mild situational insomnia, and doses up to 15 g at bedtime may be necessary for severe insomnia. (psychologytoday.com)
  • Combining 2 g of l-tryptophan with 20 mg per day of fluoxetine resulted in more rapid response and improved sleep quality in depressed patients complaining of chronic insomnia. (psychologytoday.com)
  • COPD patients with daytime arterial oxygen partial pressure in the range 56-69 mmHg were included prospectively. (ersjournals.com)
  • When COPD and obstructive sleep apnea (OSA) exist together, it is called overlap syndrome. (ucsd.edu)
  • At UC San Diego Health, many patients who have COPD are also screened for OSA as the two conditions combined significantly increase your risk for cardiovascular disease and mortality. (ucsd.edu)
  • Observational studies comparing circulating leptin levels between COPD patients and healthy controls were included. (karger.com)
  • Circulating leptin levels were correlated with the body mass index (BMI) as well as percent fat mass in stable COPD patients. (karger.com)
  • A positive correlation between leptin and tumor necrosis factor (TNF)-α levels was found in COPD exacerbations, while it disappeared in patients with stable disease. (karger.com)
  • Most studies indicated that circulating leptin levels in stable COPD patients were not significantly different from those in healthy controls when adjusted for gender and BMI, whilst leptin levels tended to elevate in exacerbation groups. (karger.com)
  • The normal regulatory mechanism of leptin is maintained in stable COPD patients despite weight loss. (karger.com)
  • The additional correlation between leptin and TNF-α during exacerbations may support the closer association of leptin with changes in nutritional parameters and suggests its valuable role in the evaluation of systemic inflammatory responses in COPD patients during exacerbation, which merits further study. (karger.com)
  • Anlotinib in patients with recurrent platinum resistant/refractory ovarian cancer: a prospective, single arm, phase II study. (cdc.gov)
  • however, the term syndrome is now reserved for those errors of morphogenesis with the simultaneous presence of multiple anomalies caused by a single etiology. (medscape.com)
  • Due to this, partial reduction in breathing (hypopneas) and absolute pauses (apneas) happen in breathing and sudden reductions in blood saturation can be generated. (healthjockey.com)
  • In patients with nocturnal enuresis, the history and physical examination are usually sufficient to rule out a urologic abnormality. (medscape.com)
  • In the John Hopkins University adult Sleep Center, the polysomnographic results were corresponded and judged against the retrospective control sample of 48 adult patients who went through the regular diagnostic nocturnal polysmnography. (healthjockey.com)
  • Obstructive sleep apnoea (OSA) is defined by repeated nocturnal episodes of pharyngeal obstruction with resultant intermittent hypoxia (IH), reoxygenation and arousals from sleep. (wiley.com)
  • IV lidocaine can significantly reduce the amount of propofol, the incidence of hypoxia and postoperative pain during gastroscopy in elderly patients, with a higher patient and gastroscopist satisfaction. (dovepress.com)
  • It is usually observed in patients with unobstructed nasal passages following surgical intervention who report sensations of suffocation or obstruction following recovery. (wikipedia.org)
  • Patients affected by obstructive sleep apnea (OSA) present an increased risk of cardiovascular (CV) events [1]. (efim.org)
  • Each parent or guardian completed two sets of questions for his or her child: the OSA 18 and the Pediatric Sleep Questionnaire (PSQ). (scienceblog.com)
  • A survey of veterans in northeast Ohio using the Cleveland Sleep Habits questionnaire (7) showed that 46% of the respondents were at high risk for OSA (7). (cdc.gov)
  • From a systematic review of previously published cases to date, ocular abnormalities are present in more than half of patients with the syndrome. (hindawi.com)
  • Comorbid association of obstructive sleep apnea (OSA) and thrombotic primary antiphospholipid syndrome (tPAPS): A more severe phenotype? (cdc.gov)
  • The mechanisms of complications in these patients are unclear. (uwi.edu)
  • Regardless of the presence or absence of comorbidity, the OSA patients exhibited a higher risk than did the individuals in the comparison group. (acc.org)
  • Obstructive sleep apnea syndrome (OSA) occurs in 2-4% of adults, increasing by 2.5 times the risk of sudden death. (nel.edu)
  • A latest study by experts at the University of Pennsylvania on obstructive sleep Apnea (OSA) reveals that the condition is also suffered by adults with Down syndrome. (healthjockey.com)
  • As per them adults with Down syndrome have even more influencing factor for OSA than children, as they still have the craniofacial anomalies and they have more tendency to be obese or hypothyroid. (healthjockey.com)
  • The study incorporated information from 16 adults with Down syndrome who went through the assessment for sleep disordered breathing. (healthjockey.com)
  • Obstructive sleep apnea (OSA), a condition characterized by repeatedly interrupted breathing during sleep, occurs frequently in adults (1). (cdc.gov)
  • Objective Children with Down syndrome are at high risk of obstructive sleep apnoea (OSA) and screening is recommended. (bmj.com)
  • In two patients, non-coding regions contained genetic alterations, including, in one individual, "a deep 229-bp intronic deletion" that produced a splicing error. (medscape.com)
  • Genetic screening for rare syndromes is indicated only in the presence of specific historical or physical features. (medscape.com)
  • Case Report: Cancer spectrum and genetic characteristics of a de novo germline POLD1 p.L606M variant-induced polyposis syndrome. (cdc.gov)
  • Genetic investigation of Nordic patients with complement-mediated kidney diseases. (cdc.gov)
  • For the planning of this known that this examination has a higher cost and the patient surgery, all data obtained in the patient evaluation , including is subjected to a higher radiation index. (bvsalud.org)
  • Treatment modalities can be adapted easily to the youth's developmental level and should consider the role of sleep hygiene in all sleep problems. (medscape.com)
  • Progressive Multifocal Leukoencephalopathy associated to treatment with natalizumab in Mexican patient Multiple Sclerosis. (nel.edu)
  • Quiñones-Aguilar S, Sauri-Suárez S, Alcaraz-Estrada S, García S. Progressive Multifocal Leukoencephalopathy associated to treatment with natalizumab in Mexican patient Multiple Sclerosis. (nel.edu)
  • The implantable device offers a gentler treatment for these young patients. (tgh.org)
  • In an open study, almost half of treatment-refractory depressed patients (N=100) responded to 5-HTP (up to 600 mg per day) in combination with 150 mg per day of carbidopa after several weeks of treatment. (psychologytoday.com)
  • Case reports show that some treatment-refractory patients improve when 300 mg per day of 5-HTP is combined with carbidopa (a peripheral monoamine oxidase inhibitor (MAOI), tricyclic antidepressants , MAOIs, or serotonin selective reuptake inhibitors (SSRI). (psychologytoday.com)
  • Our fully-licensed staff will perform your study, which is interpreted by a board-certified sleep medicine specialist and then shared with your primary care physician for appropriate treatment. (mercy.net)
  • Ivana Rosenzweig (left) is a consultant neuropsychiatrist with research interest in the electrophysiology of sleep and the role of thalamocortical dysrhythmias in neurological and neuropsychiatric illnesses. (wiley.com)
  • Her current research focuses on the cardiovascular and neurological impact of sleep apnoea. (wiley.com)
  • One UK study 8 concluded that 16-20% of motor vehicle crashes were sleep related based on police reported data, while another 9 arrived at a figure of 9-10% based on drivers' self-reports. (bmj.com)
  • Intervention Diagnostic multichannel sleep study and HPO. (bmj.com)
  • The study subjects were 66 male patients with OASHS matched against a set criteria. (somnowell.com)
  • The overall incidence of ENS is unknown due to the small body of epidemiological study and the lack of a dedicated International Classification of Diseases (ICD-10) code, which would allow incidence reporting of the syndrome. (wikipedia.org)
  • A limited study of ENS patients found that ENS is associated with hyperventilation syndrome (HVS) in 77.3% of the study population. (wikipedia.org)
  • All but one study [79] did not exclude patients with severe OSA. (researchgate.net)
  • 3,511 patients with OSA and 35 110 sex and age matched comparison individuals were included in this study. (acc.org)
  • In this study, however, all patients were pleased with the eyelid correction and no patient requested an additional ptosis correction,' continued Dr. Meyer, professor of ophthalmology at Albany Medical College, Albany, NY. (ophthalmologytimes.com)
  • The local association of retarded citizens (ARC), Parents of Down Syndrome (PODS) group meetings and the Kennedy Krieger Down syndrome Clinic were the places from where the subjects were enlisted for the study. (healthjockey.com)
  • Godbout et al (2013) published a study comparing anatomical cleft parameters between isolated cleft palate patients and Pierre Robin syndrome patients. (medscape.com)