Patients with moderate or severe chronic obstructive pulmonary. Medical search. Frequent questions

The combined therapy of Bufei Yishen granules (BY) and electroacupuncture (EA) has shown good effects clinically in treating chronic obstructive pulmonary disease (COPD). (hindawi.com)
Pulmonary function was markedly decreased in the COPD rats, and the lung tissue histology of the COPD rats showed severe pathological changes. (hindawi.com)
The increased levels of the inflammatory cytokines interleukin (IL)-1 β and IL-6 indicated a chronic inflammatory state in the COPD rats. (hindawi.com)
Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow limitation [ 1 ]. (hindawi.com)
Approximately 65 million patients suffer from moderate to severe COPD worldwide [ 2 ]. (hindawi.com)
In 2017, 3.91 million all-age deaths worldwide were due to chronic respiratory diseases, including 3.19 million deaths from COPD [ 4 ]. (hindawi.com)
In addition, COPD seriously affects patients' quality of life and is one of the leading causes of disability adjusted life years (DALYs) [ 5 ]. (hindawi.com)
The recommended pharmacotherapy for the treatment of COPD is generally bronchodilators ( β 2 agonists and long-acting anticholinergic agents) in patients with mild disease [ 15 , 16 ]. (hindawi.com)
An acute exacerbation of chronic obstructive pulmonary disease, or acute exacerbations of chronic bronchitis (AECB), is a sudden worsening of chronic obstructive pulmonary disease (COPD) symptoms including shortness of breath, quantity and color of phlegm that typically lasts for several days. (wikipedia.org)
High-flow nasal cannula oxygen therapy for admitted COPD-patients. (wikipedia.org)
COPD is a progressive disease in which many patients develop an acute or sustained deterioration. (nature.com)
CID was defined as any of the following: ≥100 mL decrease from baseline in pre-dose forced expiratory volume in 1 second (FEV 1 ), ≥4 point increase in St George's Respiratory Questionnaire score or a moderate-to-severe COPD exacerbation occurring after the first dose of study medication. (nature.com)
Patients had moderate (62%) or severe (38%) COPD. (nature.com)
Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition comprising multiple pulmonary and extra-pulmonary manifestations. (nature.com)
5 The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 strategy now recommends that COPD management should consider both disease impact (i.e., assessment of symptoms) measured by the COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scale, and exacerbation history. (nature.com)
Glycopyrronium is a once-daily LAMA indicated for the maintenance treatment of patients with COPD. (nature.com)
6 Phase III trials have shown that glycopyrronium produces rapid and sustained improvements in lung function, symptoms, health status, exercise endurance and exacerbation risk in patients with COPD. (nature.com)
COPD clinical trials primarily focus on bronchodilator response using minimal clinically important difference (MCID) to determine improvements in lung function and patient-reported outcomes. (nature.com)
Over the past 2 decades, there has been increasing interest in the extrapulmonary manifestations of chronic obstructive pulmonary disease (COPD). (bmj.com)
1 Furthermore, the forced expiratory volume in 1 s is an imperfect predictor of mortality in severe patients with COPD, 2 and when forced expiratory volume in 1 s is corrected after double lung transplantation, peak exercise remains only approximately 50% of predicted up to 1-2 years after surgery. (bmj.com)
Certainly, a surprisingly high proportion of patients with COPD terminate exercise complaining of muscle effort. (bmj.com)
7 Studies in patients with COPD have been either cross-sectional or longitudinal without an adequate control group, and it has been difficult to tease out the influence of confounding factors. (bmj.com)
This study is therefore both novel and welcome in that it provides longitudinal data about decline in body composition and physical functioning in both patients with presumed COPD and well-matched (smoking, never-smoking and formerly smoking) controls. (bmj.com)
The PILLAR Study: A Clinical Trial for Patients Diagnosed with Chronic Obstructive Pulmonary Disease (COPD) with an Inhaled Maintenance Triple Therapy. (clinicalconnection.com)
Over 65 million people globally have moderate to severe Chronic Obstructive Pulmonary Disease (COPD). (clinicalconnection.com)
COPD is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. (clinicalconnection.com)
Although maintenance therapies have improved the lives of patients with Chronic Obstructive Pulmonary Disease (COPD), some individuals on maintenance triple therapy for COPD still have symptoms or experience COPD exacerbations, which can result in a hospital admission. (clinicalconnection.com)
Latent infection with adenovirus and respiratory syncytial virus (RSV) is associated with chronic obstructive pulmonary disease (COPD). (spandidos-publications.com)
Twenty seven patients with COPD‑AE were evaluated using a prospective longitudinal study design. (spandidos-publications.com)
Induced sputum, sera and nasal smears were sampled from patients experiencing COPD‑AE and those in a stable condition. (spandidos-publications.com)
Eighteen patients who experienced a COPD‑AE were also evaluated while in a stable condition. (spandidos-publications.com)
RSV serotype A was detected in 17/27 (63%) patients with COPD‑AE and 10/18 (55.6%) patients in a stable condition. (spandidos-publications.com)
Eight/ten patients who were positive for RSV serotype A while in a stable condition, were also positive during COPD‑AE. (spandidos-publications.com)
The results of the present study suggested that RSV infection may be prevalent in patients with COPD‑AE and in those in a stable condition. (spandidos-publications.com)
Therefore, chronic RSV infection may occur in COPD. (spandidos-publications.com)
Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disease characterized by exacerbations, which are primarily caused by bacterial or viral infections. (spandidos-publications.com)
Respiratory viral infections occurring during COPD exacerbations are more likely to lead to hospitalization as a result of viral infections leading to a greater airway inflammation and therefore, more severe exacerbations. (spandidos-publications.com)
However, chronic adenovirus and RSV infection data are currently unclear and, to the best of our knowledge, few longitudinal studies have been conducted on the association between chronic infection and COPD. (spandidos-publications.com)
Furthermore, RSV chronic infection in COPD and its consequences for local and systemic infection, and functional status have yet to be fully elucidated. (spandidos-publications.com)
The aim of the present study was to investigate the prevalence of adenovirus and RSV A and B among patients with COPD-AE and those in a stable condition. (spandidos-publications.com)
The present study evaluated the association between viral infections, functional status and systemic inflammation in patients experiencing COPD-AEs and those in a stable condition. (spandidos-publications.com)
Diagnosis and spirometric assessment of the severity of COPD was performed according to the global initiative for chronic obstructive lung disease (GOLD) criteria ( 11 ). (spandidos-publications.com)
To better define the role of anxiety in chronic obstructive pulmonary disease (COPD), a study was conducted of the inter-relations between anxiety and COPD in a large cohort of subjects with COPD and a matched control group. (bmj.com)
Methods Data were used from the FLOW (Function, Living, Outcomes, and Work) cohort of patients with COPD (n=1202) and matched controls without COPD (n=302). (bmj.com)
Once anxiety develops among patients with COPD, it is related to poorer health outcomes. (bmj.com)
Chronic obstructive pulmonary disease (COPD) is an important cause of respiratory symptoms, disability and other poor health outcomes. (bmj.com)
A conundrum of COPD treatment is that patients with a given level of lung function may differ substantively in their symptom burden and activity limitation. (bmj.com)
Anxiety is likely to be a problem for many patients with COPD. (bmj.com)
There remain significant unanswered questions about the prevalence and impact of anxiety among patients with COPD. (bmj.com)
The inflammatory process in patients with stable COPD is dominated by macrophages, CD8+ T‐lymphocytes and neutrophils, and to a lesser extent mast cells, in the bronchial submucosa and alveoli 5 . (ersjournals.com)
Attenuation of oxidative stress would be expected to result in reduced pulmonary damage and a decrease in local infections, contributing to attenuation of the progression of COPD. (ersjournals.com)
At present the only antioxidant widely available for the treatment of patients with COPD is N ‐acetylcysteine (NAC). (ersjournals.com)
Male sex, older age, preexisting comorbidities (cardiovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease [COPD]), use of insulin, and high blood glucose on hospital admission were associated with increased risk for COVID-19-related death, whereas metformin use was associated with lower risk, based on moderate-to-strong evidence. (medscape.com)
Having COPD was associated with a 21% increased risk for death from COVID-19 and a 36% increased risk for severe COVID-19. (medscape.com)
Effect of roflumilast on exacerbation rate in patients with COPD treated with fixed combinations of LABA and ICS. (astrazenecaclinicaltrials.com)
The objective of the REACT trial is to investigate the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate and pulmonary function in COPD patients who are concomitantly treated with a fixed combination of long-acting β2-agonists (LABA) and inhaled glucocorticosteroids (ICS). (astrazenecaclinicaltrials.com)
Patients to be included are required to have severe COPD associated with chronic bronchitis and a history of frequent exacerbations and must be concomitantly treated with a fixed combination of LABA and ICS. (astrazenecaclinicaltrials.com)
Roflumilast is being developed to treat people who have chronic obstructive pulmonary disease (COPD). (astrazenecaclinicaltrials.com)
This study investigated the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate, pulmonary function, and major adverse cardiovascular events (MACE) in COPD patients who were concomitantly treated with a fixed combination of long-acting beta-agonists (LABA) and inhaled glucocorticosteroids. (astrazenecaclinicaltrials.com)
MARLBOROUGH, Mass.--( BUSINESS WIRE )-- Sunovion Pharmaceuticals Inc. (Sunovion) today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for SUN-101/eFlow ® , an investigational treatment for the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). (biospace.com)
GOLDEN-3 and GOLDEN-4 were Phase 3, 12-week, randomized, double-blind, placebo-controlled, parallel-group, multicenter efficacy and safety trials comparing SUN-101/eFlow ® with placebo in patients with moderate-to-very severe COPD. (biospace.com)
GOLDEN-5 was a Phase 3, 48-week, randomized, open-label, active-controlled, parallel-group, multicenter safety trial designed to evaluate the long term safety and tolerability of SUN-101/eFlow ® in patients with moderate-to-very severe COPD. (biospace.com)
This is an important milestone for us and the larger respiratory community, as we continue our mission of pioneering innovative treatments and therapies for COPD patients, their caregivers and healthcare providers. (biospace.com)
SUN-101 (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator delivered via the innovative, proprietary investigational eFlow ® nebulizer closed system for the treatment of patients with moderate-to-very severe chronic obstructive pulmonary disease (COPD). (biospace.com)
GOLDEN (Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer)-3 and GOLDEN-4 were Phase 3, 12-week, randomized, double-blind, placebo-controlled, parallel-group, multicenter, efficacy and safety trials comparing SUN-101/eFlow ® with placebo in adults with moderate-to-very severe COPD. (biospace.com)
GOLDEN (Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer)-5 was a Phase 3, 48-week, randomized, open-label, active-controlled, parallel-group, multicenter safety trial designed to evaluate the long term safety and tolerability of SUN-101/eFlow ® in adults with moderate-to-very severe COPD. (biospace.com)
Although interstitial lung disease (ILD) is the primary manifestation of RA in the lungs, there is strong emerging evidence that airway diseases including asthma and chronic obstructive pulmonary disease (COPD) affect both the course and mortality of RA. (nih.gov)
There is uncertainty about the interpretation of changes in the 6-min walk distance (6MWD) in chronic obstructive pulmonary disease (COPD) patients and whether the minimal important difference (MID) for this useful outcome measure exists. (ersjournals.com)
Data were used from nine trials enrolling a wide spectrum of COPD patients with 6MWD at baseline and follow-up and used to determine threshold values for important changes in 6MWD using three distribution-based methods. (ersjournals.com)
Data were included of 460 COPD patients with a mean± sd forced expiratory volume in one second (FEV 1 ) of 39.2±14.1% predicted and 6MWD of 361±112 m at baseline. (ersjournals.com)
Medical aerosols are key elements of current chronic obstructive pulmonary disease (COPD) therapy. (mdpi.com)
Sanofi and Regeneron are researching if an investigational medicine plus certain controller therapies could potentially lessen COPD symptoms and improve breathing and overall well-being in former smokers (>10 packs year) who are between 40 and 85 years old with moderate-to-severe COPD. (acaai.org)
This global, multi-center, phase 3 clinical trial (AERIFY 2) is a randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/ REGN3500/ Itepekimab (Anti-IL-33 mAb) in former smokers with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD). (acaai.org)
Treatments for chronic obstructive pulmonary disease (COPD) may still leave you looking for relief from wheezing, coughing, and shortness of breath. (acaai.org)
This study elucidates whether the GOLD 2017 classification is associated with different future exacerbation risk in patients with chronic obstructive pulmonary disease (COPD) compared with the previous GOLD categorization. (archbronconeumol.org)
We analyzed patients from three prospective COPD cohorts (SNUH, KOCOSS, and KOLD) and evaluated the risk of moderate to severe exacerbation among different models, including GOLD grade (FEV1), GOLD 2011, and GOLD 2017. (archbronconeumol.org)
As an NP with in the Internal Medicine Clinic (IMC), I manage two similar programs - Telehomecare Programs for Chronic Heart Failure (CHF) and Chronic Obstructive Pulmonary Disease (COPD). (tbrhsc.net)
Using specialized remote monitoring technology, I am able to monitor, manage and treat patients with severe to very severe CHF and moderate to very severe COPD patients from the comfort of their own home, helping to reduce visits to the Emergency Department. (tbrhsc.net)
A potential first-in-class treatment for chronic obstructive pulmonary disease (COPD), Verona Pharma 's RPL554 is being tested as a nebulised maintenance treatment for patients with moderate to severe disease. (pmlive.com)
It will prioritise this health need with a specific focus on a holistic approach to nursing assessment, when assessing patients with Chronic Obstructive Pulmonary Disease, known as COPD. (ukessays.com)
COPD is one of the respiratory diseases which requires palliation of symptoms, is known to have four stages within its disease trajectory beginning with mild, moderate and progressing to moderately severe (Currie, 2017). (ukessays.com)
Understanding the breadth of patients' support needs is important for the delivery of person-cantered care, particularly in progressive long-term conditions such as chronic obstructive pulmonary disease (COPD). (ukessays.com)
Although COPD is a bracket name given to multiple lung conditions such as emphysema and chronic bronchitis the two conditions are very similar and often present with similar symptoms. (ukessays.com)
Introduction: Chronic obstructive pulmonary disease (COPD) is common in heart failure (HF) with a mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and is associated with worse outcomes. (gla.ac.uk)
Patients with severe pulmonary disease (including COPD) were excluded from the trial. (gla.ac.uk)
Of the 6261 patients with data on baseline COPD status, 694 (11.1%) had a known history of this condition. (gla.ac.uk)
The risk of the primary endpoint was higher in patients with mild-to-moderate COPD compared with those without COPD (adjusted HR: 1.28 (95% CI: 1.08-1.51). (gla.ac.uk)
Dapagliflozin, as compared with placebo, improved the KCCQ scores from baseline to 8 months to a similar extent in patients with and without mild-to-moderate COPD (Pinteraction ≥0.63). (gla.ac.uk)
Conclusions: Mild-to-moderate COPD is common in patients with HFmrEF/HFpEF and is associated with worse outcomes. (gla.ac.uk)
Background: Pain is a common symptom in people with chronic obstructive pulmonary disease (COPD) which negatively influences quality of life and psychological well-being. (monash.edu)
Objectives: To explore how individuals with moderate to severe COPD experience pain. (monash.edu)
Methods: Eight patients diagnosed with COPD who reported experiencing pain for greater than three months participated in in-depth interviews. (monash.edu)
Several novel gene variants may help explain the response of patients with chronic obstructive pulmonary disease (COPD) to inhaled bronchodilators, according to a meta-analysis reported today (Oct. 25) at the American Society of Human Genetics 2013 meeting in Boston. (ashg.org)
The meta-analysis used statistical methods to combine results from four individual studies with a total of 5,789 Caucasian patients with moderate to severe COPD. (ashg.org)
Over 6.3 million unique single nucleotide polymorphisms (SNPs) were identified in the genotypes of the patients with COPD, which is a progressive breathing disorder that limits airflow in the lungs. (ashg.org)
In the presentation today, Dr. Hardin reported the top SNPs that thus far have been associated with each BDR outcome, but emphasized that additional analysis may reveal other SNPs with equally or greater influence on COPD patients' response. (ashg.org)
This descriptive-analytical study was performed on patients with COPD that were diagnosed by spirometry and GOLD guides. (jcbior.com)
Out of 119 patients with COPD, about 74.8% were males and 25.2% were females. (jcbior.com)
Celli BR, MacNee W. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. (jcbior.com)
Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. (msdmanuals.com)
Patients with chronic obstructive pulmonary disease (COPD) are susceptible to early muscle fatigue. (fapesp.br)
The objective of this study is to investigate the acute effects of LED on muscle function, exercise capacity, and cardiorespiratory responses during isometric and dynamic exercise in patients with COPD. (fapesp.br)
The therapeutic effects of LED could minimize muscle fatigue in patients with COPD by increasing exercise tolerance. (fapesp.br)
however, few clinical studies have investigated treatment effectiveness in COPD patients with destroyed lung by TB. (korea.ac.kr)
The Indacaterol effectiveness in COPD patients with Tuberculosis history (INFINITY) study assessed the efficacy and safety of once-daily inhaled indacaterol 150 µg for the treatment of Korean COPD patients with destroyed lung by TB and moderate-to-severe airflow limitation. (korea.ac.kr)
Conclusion: Indacaterol provided significantly superior bronchodilation, significant improvement in breathlessness and improved health status with comparable safety versus placebo in Korean COPD patients with destroyed lung by TB and moderate-to-severe airflow limitation. (korea.ac.kr)
The study included 12 healthy smokers, 15 patients with moderate to severe COPD, and 11 healthy nonsmokers. (hcplive.com)
Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. (e-trd.org)
This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 μg to indacaterol/glycopyrronium (IND/GLY) 110/50 μg once daily in COPD patients in Korea. (e-trd.org)
This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 μg once daily for ≥12 weeks prior to study initiation. (e-trd.org)
The prevalence of chronic obstructive pulmonary disease (COPD) is considerably high, affecting 251 million patients globally. (e-trd.org)
Fifty patients have COPD based on CT criteria. (springeropen.com)
The presence of COPD by imaging criteria in the settings of COVID-19-associated pneumonia did not significantly influence the clinical or imaging performance of the patients, nor was it linked to the increased in-hospital mortality. (springeropen.com)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, the overall 5-year survival for COPD patients is between 56 and 92% depending on the severity of the disease [ 4 , 5 ]. (springeropen.com)
Background: To determine the importance of spirometric testing for early detection of chronic obstructive pulmonary disease (COPD). (moam.info)
Subjects with a postbronchodilator forced expiratory volume in one second/forced vital capacity ,0.70 were defined as having COPD, according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. (moam.info)
Conclusion: These results suggest that spirometry testing could detect patients with COPD in the earlier stages of the disease. (moam.info)
Patient with an exacerbation of chronic obstructive pulmonary disease (COPD) undergoing treatment with noninvasive ventilation using an orofacial mask. (medscape.com)
According to a recent study, patients with COPD who present with sepsis may do better when medication addresses inflammation. (medscape.com)
Tiotropium for Mild to Moderate COPD Is it time to consider using a daily long-acting bronchodilator like tiotropium for early-stage COPD? (medscape.com)
Oxygen for Moderate COPD? (medscape.com)
Is oxygen therapy beneficial in patients with moderate COPD? (medscape.com)

The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. (spandidos-publications.com)
However, they also suggest that not systematically collecting exacerbation history before patients were enrolled could be a weakness of the study. (hcplive.com)

Exacerbations can be classified as mild, moderate, and severe. (wikipedia.org)
Viruses are associated with more severe exacerbations and with greater morbidity, therefore, require further research ( 1 ). (spandidos-publications.com)
The antioxidant N ‐acetylcysteine, a glutathione precursor, has been applied in these patients in order to reduce symptoms, exacerbations and the accelerated lung function decline. (ersjournals.com)
Emotions such as anxiety, anger, visits to the pulmonary clinic in the past happiness, excitement, satisfaction and to participate in the study, had a previ- year and frequency of hospital admis- neutral emotions have been shown to ous diagnosis of asthma and were in a sions for asthma exacerbations in the influence forced expiratory volume in stable medical condition with no other past year [12]. (who.int)
Dr Nicholas Gross on a flawed but promising study of patients with acute exacerbations of this too-often fatal condition. (medscape.com)

The term "exercise induced bronchoconstriction" is preferred to that of "exercise induced asthma" since asthma is a chronic condition which is not induced by a single bout of exercise. (bmj.com)
Sanofi and Regeneron are studying the long-term effect of dupliumab on the prevention of lung function decline in adult patients with uncontrolled moderate to severe asthma. (acaai.org)
This Phase 3b/4 study (ATLAS), is an interventional, randomized, parallel group, treatment, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe asthma. (acaai.org)
Notes: Sponsored clinical trial for patients with Severe Uncontrolled Asthma . (yale.edu)
Notes: Observational and in-interventional study open to population with severe asthma. (yale.edu)
The aim of this cross-sectional study was to evaluate the prevalence of depressed mood among asthma patients ( n = 280) attending a pulmonary clinic in Tehran and compare it with measures of severity of asthma and of health and well-being. (who.int)
Patients' individual scores on the GHQ-28 were significantly correlated with the number of asthma medications used, frequency of visits to the pulmonary clinic and frequency of hospitalizations for asthma, but not with FEV1. (who.int)
The GHQ-28 may be useful for screening for asthma patients who need more attention and therapeutic intervention for psychiatric disorders. (who.int)
The Global Initiative for Asthma defines asthma as a heterogeneous disease characterized by chronic inflammation of the airways, with a history of respiratory symptoms, such as wheezing, dyspnea, chest tightness, cough and variable airflow limitation 1 . (bvsalud.org)
Choosing the Optimal Biologic for Severe Asthma Care pathways are available to help clinicians select biologic agents for patients with severe asthma. (medscape.com)
More Signs of Success for Benralizumab in Severe Asthma Dr Nicholas Gross on the latest positive data and the many crucial questions that remain. (medscape.com)
Is There a Role for Weight Loss in Obese Patients With Asthma? (medscape.com)
Extra pounds spell trouble for asthma patients. (medscape.com)

Azithromycin: Hope for Idiopathic Pulmonary Fibrosis? (medscape.com)

Patients with severe sleep apnea: ROZEREM is not recommended for use in this population. (guidelinecentral.com)
In the 1980s, increasing experience with positive-pressure ventilation delivered through a mask in patients with obstructive sleep apnea led to this type of ventilatory support, initially in patients with neuromuscular respiratory failure. (medscape.com)
Obstructive sleep apnea (OSA) is a common disorder that is associated with significant morbidity. (cdc.gov)
Obstructive sleep apnea (OSA), a condition characterized by repeatedly interrupted breathing during sleep, occurs frequently in adults (1). (cdc.gov)
Recent research explored whether there are gender differences in effectiveness of CPAP for obstructive sleep apnea. (medscape.com)
Obstructive Sleep Apnea: Targeting the Low Arousal Threshold Dr Holley weighs in on research needs for targeted therapies in obstructive sleep apnea. (medscape.com)

1-4 Nonetheless, many patients continue to suffer from marked respiratory symptoms and activity limitation despite optimal medical management. (bmj.com)
The third trial 5 presented results as the proportion of days rated in patients' diaries as having mild, moderate or severe respiratory symptoms. (bmj.com)
9 Decision makers would want to know how confident we are in the effect of these programmes to improve respiratory symptoms before offering such programmes to patients with chronic obstructive pulmonary disease. (bmj.com)
28: moderate-to-severe depressive symptoms. (bmj.com)
Using the cut-offs on the WHO-5, 533 persons (31%) were found to have moderate-to-severe depressive symptoms, 479 (28%) had mild depressive symptoms and 724 (42%) had a good well-being. (bmj.com)
Multivariable logistic regression revealed that higher disease activity, higher level of functional impairment, lower income, self-reported stress and lack of exercise, and younger age represent factors associated with moderate-to-severe depressive symptoms. (bmj.com)
Some patients have had additional symptoms such as dyspnea, throat closing, or nausea and vomiting that suggest anaphylaxis. (nih.gov)
Recurrence of COVID-19 symptoms and positive SARS-CoV-2 test results have been reported after completion of Paxlovid oral antiviral treatment for COVID-19, but real-world evidence of severe illness following Paxlovid is lacking. (cdc.gov)
Symptoms of pulmonary contusion include pain (mainly due to injury to the overlying chest wall) and sometimes dyspnea. (msdmanuals.com)
Pulmonary contusion should be suspected when respiratory distress develops after chest trauma, particularly when symptoms worsen gradually. (msdmanuals.com)
Patients with more sleep-related symptoms appear to receive greater benefit from treatment than do patients with fewer sleep-related symptoms (10). (cdc.gov)

As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerges, we report 2 patients with COVID-19 and laboratory-confirmed TB and 1 with COVID-19 and clinically diagnosed TB in China. (cdc.gov)

The decision to vaccinate is informed by whether the patient has any risk factors for severe RSV disease, a patient's risk of exposure to RSV, a patient's preferences for RSV vaccination, and the clinical discretion of the health care provider. (cdc.gov)
This is supported by the clinical observation that patients show significant improvements in functional performance and health-related quality of life with pulmonary rehabilitation in the absence of lung function changes. (bmj.com)
The clinical diagnosis was active pulmonary TB, tuberculous pleuritis, and pleural effusion. (cdc.gov)
This article reviews the presently available experimental and clinical data on the antioxidative effects of N ‐acetylcysteine in chronic obstructive pulmonary disease. (ersjournals.com)
Patients are at the heart of everything we do at Sunovion," said Antony Loebel, M.D., Executive Vice President and Chief Medical Officer at Sunovion, Head of Global Clinical Development for Sumitomo Dainippon Pharma Group. (biospace.com)
Involvement in clinical trials provides the opportunity to further medical research and improve patient outcomes. (acaai.org)
Clinical and demographic characteristics from EHRs were described among patients receiving Paxlovid during December 31, 2021-May 26, 2022, within KPSC, a large integrated health care system in California. (cdc.gov)
Patients should be monitored for respiratory failure with serial clinical assessments and pulse oximetry. (msdmanuals.com)
This study aimed to determine the prevalence of antibiotic therapy in patients with COVID-19 infection and explore the association of antibiotic prescribing with patients' demographics and clinical characteristics. (who.int)
Of a total of 312 titles, eight studies were included, of which six are randomized clinical trials and two are observational studies All the studies included breathing exercises, with the objective of adjusting breathing patterns and pulmonary ventilation, reducing pulmonary hyperinflation, bronchospasm and sensation of dyspnea. (bvsalud.org)

Local and systemic inflammation in patients with chronic obstructive pulmonary disease: soluble tumor necrosis factor receptors are increased in sputum. (jcbior.com)

The objectives of this study were to determine the distributions of weight-adjusted bone mass content and osteoporosis in chronic obstructive pulmonary disease patients, to examine the prevalence of osteoporosis and osteopenia and to determine factors associated with weight-adjusted bone mass content. (ijpsonline.com)
Antibiotic use was high among patients with confirmed COVID-19 despite a low prevalence of confirmed bacterial coinfection. (who.int)

NCDs, namely cardiovascular diseases, cancer, diabetes and chronic respiratory diseases, are largely preventable by addressing the four common modifiable risk factors - tobacco use, harmful use of alcohol, unhealthy diet and physical inactivity. (who.int)
Having cardiovascular disease or chronic kidney disease was associated with a 56% and 93% increased risk of dying from COVID-19, respectively, based on weaker evidence. (medscape.com)

In a double-blind placebo-controlled cross-over study, patients performed spirometry and symptom-limited constant-load cycle exercise before and 1 h after receiving 500 micrograms of nebulized ipratropium bromide (IB) or saline placebo. (nih.gov)
Patients with restrictive spirometry were excluded from analysis. (bmj.com)
All patients were genotyped, and their lung function was tested by spirometry before and after they used the bronchodilator medication albuterol, which relaxes muscles in the airways and increases airflow to the lungs. (ashg.org)

Victor Kim, MD, of the Division of Pulmonary and Critical Care Medicine at Temple University School of Medicine, in Philadelphia, Pennsylvania and colleagues published the results of their study in PLOS ONE . (hcplive.com)

The researchers wanted to examine the relationship between goblet cell hyperplasia and smoking to find out if people with chronic bronchitis and current smokers would have more GCD, whether or not they had any airflow obstruction. (hcplive.com)
Participants with chronic bronchitis also had greater GCD. (hcplive.com)
Despite the possible weaknesses, the researchers "were able to demonstrate in this small sample that current smoking and chronic bronchitis, and not airflow obstruction, were independent factors associated with goblet cell hyperplasia. (hcplive.com)

However, "interestingly," the meta-analysis did not find that obesity or hypertension were associated with an increased risk for severe COVID-19 or death from COVID-19. (medscape.com)

RA-ILD and airway disease generally can be found in combination in the same patient, a finding that favors the diagnosis of rheumatoid lung disease. (nih.gov)

5 Psychological functioning in particular may influence why two patients with the same degree of lung function impairment have different health outcomes. (bmj.com)
Ramelteon Tablets are not recommended in patients with severe hepatic impairment. (nih.gov)
Dose adjustment is not necessary in patients with renal impairment. (who.int)
ROZEREM is not recommended in patients with severe hepatic impairment. (guidelinecentral.com)
Of these, 10.2% had an obstructive pattern of ventilatory impairment and 6% had a restrictive pattern. (moam.info)

CVDs), cancer, diabetes and chronic respiratory diseases (CRDs), are the leading causes of morbidity and mortality worldwide. (who.int)

Diabetes increases the risk of dying from COVID-19, but the patient characteristics and diabetes-related factors associated with the increased risk for COVID-19 severity or death have not been totally clear. (medscape.com)
Factors associated with weight-adjusted bone mass content of the extremities was the severity of chronic obstructive pulmonary disease (adjusted odds ratios of moderate and severe chronic obstructive pulmonary disease were 1.03 and 1.06), waist circumference (adjusted odds ratio 0.99) and appendicular skeletal mass index (adjusted odds ratio 0.98). (ijpsonline.com)
The severity of the disease ranges from asymptomatic infections to severe pneumonia with respiratory failure or death [ 3 ]. (springeropen.com)
Only 59% of treated patients reported good adherence to treatment with positive airway pressure, and response to treatment correlated with OSA severity. (cdc.gov)

This is a retrospective study on 281 patients with RT-PCR-confirmed COVID-19 infection and CT spectrum of COVID-19 pneumonia. (springeropen.com)

Methods: This was a multicenter, double-blind, parallel-group study, in which eligible patients were randomized (1:1) to receive either once-daily indacaterol 150 µg or placebo for 8 weeks. (korea.ac.kr)

Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease. (ersjournals.com)
When administered as an early-stage treatment, Paxlovid might prevent COVID-19-related hospitalization among persons with mild-to-moderate COVID-19 who are at risk for progression to severe disease. (cdc.gov)
Nirmatrelvir/ritonavir (Paxlovid) is a combination protease inhibitor that blocks replication of SARS-CoV-2 (the virus that causes COVID-19) and has been shown to reduce the risk for hospitalization and death among patients with mild to moderate COVID-19 who are at risk for progression to severe disease* ( 1 ). (cdc.gov)
In December 2021, the Food and Drug Administration (FDA) issued an Emergency Use Authorization (EUA) for early treatment with Paxlovid among persons with mild to moderate cases of COVID-19 who are at high risk for progression to severe disease ( 2 ). (cdc.gov)

You will hear firsthand from clinicians who have treated COVID-19 patients. (cdc.gov)

This study found that hospitalization or ED encounters for COVID-19 during the 5-15 days after Paxlovid treatment was dispensed for mild to moderate COVID-19 illness were rarely identified. (cdc.gov)

Patient 1 was a 50-year-old man who became ill with fever and productive cough on December 25, 2019. (cdc.gov)

Clinicians and public health officials should be aware of underlying chronic infections such as tuberculosis in COVID-19 patients. (cdc.gov)

12 The investigators retrospectively used baseline lung function criteria to divide the Health ABC cohort into those with obstructive lung disease (OLD) and controls. (bmj.com)
A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation. (e-trd.org)

mean +/- SEM) and moderate to severe chronic dyspnea. (nih.gov)
Early bedside physiologic studies in healthy patients and in patients with respiratory conditions document successful ventilatory support (ie, reduction in respiratory rate, increase in tidal volume, decrease in dyspnea) with reduction in diaphragmatic electromyography (EMG), transdiaphragmatic pressures, work of breathing and improvement in oxygenation with a reduction in hypercapnia. (medscape.com)

World Health Organization (WHO), as of April 2023, within 48-72 hours of hospital admission for COVID-19, 7 there have been 762 million COVID-19 cases with over and are relatively common in patients with severe and 6.8 million deaths worldwide. (who.int)

This study will assess 30 patients with moderate to severe obstruction (FEV1 d 70% predicted). (fapesp.br)

During January-February 2020, coronavirus disease (COVID-19) and tuberculosis were diagnosed for 3 patients in Wuhan, China. (cdc.gov)
To investigate this, the researchers identified studies published until October 10, 2020, of patients with type 2, and less often type 1, diabetes and COVID-19. (medscape.com)

The pulmonary function and lung tissue morphology in the treatment groups (APL, BY, EA, and BY + EA) were improved. (hindawi.com)
Medicare will not cover pacemaker implantation for either post MI patients with asymptomatic bradycardia who otherwise would be precluded from beta-blocker long-term drug therapy or post MI patients who are treated with beta-blockers and later develop asymptomatic bradycardia as a result of the treatment. (cms.gov)
For some patients, it may be appropriate to implant a pacemaker in order to continue pharmacologic treatment. (cms.gov)
Beta-blockers are a beneficial treatment for post MI patients because they decrease the incidence of recurrent cardiac events by blunting the effects of adrenaline in the body. (cms.gov)
Clinicians increasingly understand that beta-blockers are an important treatment for patients post MI. (cms.gov)
The purpose of this study is to determine the effectiveness of three doses of orvepitant, taken once a day, in the treatment of chronic refractory cough. (mayo.edu)
Selection of patients for treatment with codeine sulfate should be governed by the same principles that apply to the use of similar opioid analgesics. (rxlist.com)
Physicians should individualize treatment in every case, using non-opioid analgesics, opioids on an as needed basis and/or combination products, and chronic opioid therapy in a progressive plan of pain management. (rxlist.com)
As with any opioid drug product, adjust the dosing regimen for each patient individually, taking into account the patient's prior analgesic treatment experience. (rxlist.com)
Patients who develop angioedema after treatment with Ramelteon Tablets should not be rechallenged with the drug. (nih.gov)
Since sleep disturbances may be the presenting manifestation of a physical and/or psychiatric disorder, symptomatic treatment of insomnia should be initiated only after a careful evaluation of the patient. (nih.gov)
The most challenging part of the role is receiving the data from the patients via the telehomecare monitoring system, being able to interpret the data received, determining the relevancy of the information, and knowing how to adjust treatment options further - all without seeing the patient physically in-person. (tbrhsc.net)
however, large-scale studies investigating severe illness after Paxlovid treatment are limited. (cdc.gov)
1% of all patients to whom Paxlovid treatment was dispensed during the study period. (cdc.gov)
Results: Of the 136 patients randomized, 119 (87.5%) completed the study treatment. (korea.ac.kr)
Many patients received either improper treatment or no treatment and, subsequently, died. (medscape.com)
Success led to its adoption in other conditions, and noninvasive ventilation became especially promising in the treatment of patients with decompensated chronic obstructive pulmonary disease . (medscape.com)
Of the patients reporting good adherence, a greater proportion of those with severe OSA (27%) than with mild or moderate disease (0%-12%) reported an excellent response to treatment. (cdc.gov)
Despite the availability of numerous types of masks and interfaces, CPAP is often poorly tolerated, and it is difficult to predict which patients will adhere and respond to treatment (11). (cdc.gov)

The content within this essay is generalised across a patient group and does not relate to any specific patient, staff member or trust (NMC, 2018). (ukessays.com)

The patient received anti-TB and corticosteroid treatments and oxygen therapy. (cdc.gov)

Background Psychological functioning is an important determinant of health outcomes in chronic lung disease. (bmj.com)
Patients with diabetes had similar risk factors for worse outcomes as people in the general population, "with some exceptions. (medscape.com)
Does clinician-initiated Clostridioides difficile testing improve outcomes of patients with Clostridioides Difficile infection? (wustl.edu)

Knowing that I have the skills and judgement to be able to treat the patient and enabling them to self-manage their chronic diseases from the comfort of their own homes is one of the most rewarding aspects. (tbrhsc.net)
2. Evolving mild, moderate, and severe illness, especially infectious diseases or fever (axillary temperature 37.5oC or more) concurrent or within 7 days prior to study vaccination. (who.int)

Co-infection with severe acute respiratory syndrome coronavirus ( 4 , 5 ) or Middle East respiratory syndrome coronavirus ( 6 ) and M. tuberculosis has been associated with intensive care unit admission. (cdc.gov)
The ongoing coronavirus disease (COVID-19) pandemic is exacerbating optimal antibiotic stewardship and the promotion of bacterial resistance due to the over-prescribing of antibiotics for patients with COVID-19. (who.int)
The severe acute respiratory syndrome-related coronavirus 2 pandemic continues to this day worldwide. (springeropen.com)

9 The uncertainty of the COVID-19 pandemic Charts of confirmed COVID-19 patients who met the and the absence of antiviral treatments with proven inclusion criteria were reviewed. (who.int)
Both treatments were well tolerated by patients. (e-trd.org)

All 3 patients had COVID-19 pneumonia. (cdc.gov)

Does the use of high-flow oxygen therapy for 24 hours following extubation reduce the risk of reintubation in low-risk patients? (the-hospitalist.org)
Using high-flow nasal cannula oxygen therapy for 24 hours following extubation of patients who are already at low risk of reintubation further reduces the risk of reintubation. (the-hospitalist.org)
Using concealed allocation, these patients were randomized to receive either conventional oxygen therapy or high-flow oxygen therapy for 24 hours following extubation. (the-hospitalist.org)
CV010 trade name] is indicated for treating mild or moderate COVID-19 in adults who do not require supplemental oxygen but who are at risk of their disease becoming severe. (who.int)

Patient with decompensated congestive heart failure undergoing noninvasive ventilatory support with BiPAP ventilation and an orofacial mask. (medscape.com)

Adults ages 60 years and older who are at highest risk for severe RSV disease are most likely to benefit from vaccination. (cdc.gov)
Until additional information is available from post-marketing surveillance clarifying the existence of any potential risk, RSV vaccination in older adults may be offered to those who are at highest risk for severe RSV disease and therefore most likely to benefit from vaccination. (cdc.gov)

Chronic Kidney Disease Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. (msdmanuals.com)

Providing decision makers (patients, clinicians and policymakers) with evidence of unknown trustworthiness compromises their ability to transform evidence to action. (bmj.com)
While the ACAAI does not endorse these trials, we do encourage clinicians and their patients to partake in this valuable resource. (acaai.org)
We would like to take this opportunity to make a request of clinicians and that is, we ask that all clinicians to please remember to refer patients to their local or state health department to obtain COVID-19 testing and our test results, unless you have specific directions to provide patients otherwise. (cdc.gov)
Clinicians should not refer patients to CDC to find out where or how to get tested for COVID-19 or to get COVID-19 test results. (cdc.gov)

A crosssectional study of chronic obstructive pulmonary disease patients at a tertiary-care hospital, Thailand was conducted from May 2015 to December 2016. (ijpsonline.com)
For patients with both a documented hospital admission and an ED encounter during the 5-15 days after the date that Paxlovid was dispensed, the hospital admission was included in the analysis. (cdc.gov)

Severe anaphylactic/anaphylactoid reactions: Angioedema and anaphylaxis have been reported. (guidelinecentral.com)

These investigators recruited mechanically ventilated adult patients who were ready for extubation and who met the criteria for low risk for reintubation. (the-hospitalist.org)

Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterised by predominant involvement of the spine and/or sacroiliac joints. (bmj.com)

5 Guidelines recommend long-acting bronchodilator therapy, including long-acting muscarinic antagonists (LAMAs), as a first choice therapy in all GOLD patient groups. (nature.com)
Medicare will continue to cover pacemaker implantation in patients with symptomatic bradycardia whether iatrogenic or induced by required pharmacologic therapy. (cms.gov)
Conversely, patients receiving metformin (likely mostly for first-line therapy for type 2 diabetes) were 50% less likely to die with COVID-19 than other patients. (medscape.com)
You would need to treat 14 patients with high-flow therapy to prevent reintubation in one patient. (the-hospitalist.org)
Some patients have required medical therapy in the emergency department. (nih.gov)
Is an inhaled once-daily triple therapy effective for advanced chronic obstructive pulmonary disease? (medscape.com)

and the absence of heart failure, moderate-to-severe chronic obstructive pulmonary disease, airway patency issues, and prolonged mechanical ventilation. (the-hospitalist.org)
However, of these shared risk factors, only older age, cigarette smoking, and occupational exposures have been specifically investigated as risk factors for airway disease among patients with RA. (nih.gov)
this may be due in part to chronic airway disease and is not explained by smoking. (nih.gov)
The findings of this study suggest that "large airway epithelial mucin stores increase initially before the onset of mild airflow obstruction and then decrease as more severe disease develops. (hcplive.com)

Anatomy16

Organisms3

Diseases40

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Psychiatry and Psychology5

Phenomena and Processes37

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture1

Humanities1

Information Science2

Health Care46

Geographicals4

COPD122

Exacerbation2

Exacerbations5

Asthma13

Idiopathic pulmonar1

Apnea6

Symptoms11

Clinically1

Clinical10

Inflammation1

Prevalence2

Cardiovascular2

Spirometry3

Division of Pulmonary1

Bronchitis3

Hypertension1

Diagnosis1

Impairment5

Mortality1

Severity4

Retrospective1

Methods1

Progression4

Treated COVID-191

Hospitalization1

20191

Infections1

Lung function2

Dyspnea2

20231

FEV11

20202

Treatment19

20181

Corticosteroid1

Outcomes3

Diseases2

Coronavirus3

Treatments2

Pneumonia1

Oxygen4

Congestive1

Adults2

Kidney disease1

Clinicians4

Hospital2

Anaphylactic1

Adult1

Inflammatory1

Therapy6

Airway4