IrradiationRadiotherapyConventionalTumor controlEscalationChemotherapySquamous-cell carcRadiation therapyOrgansDifferent dosesToxicityChemoradiationMetastasesMedianFractionTumorsClinicalSurvivalChemoradiotherapyRecurrenceSBRTMetastaticLung cancerVMATRabiesTreatmentBrachytherapyOutcomeRadiochemotherapyRationaleRecurrentCisplatinNasopharyngeal carcinomaRectal cancerTotalTarget volumesHigher doseImproved patient stratificationRegimenHealthy tissuesStandardTreatmentsBoostCancerCarboplatinStratificationAdverse events
Irradiation9
- gives some additional hints that whole-body irradiation with low doses enhances the in situ vaccine effects of locally applied radiotherapy. (frontiersin.org)
- IOERT Boost: The largest evidence for boost IOERT preceding WBI comes from pooled analyses performed by the European Group of the International Society of Intraoperative Radiation Therapy (ISIORT Europe), where single boost doses (mostly around 10 Gy) preceded whole-breast irradiation (WBI) with 50 Gy (conventional fractionation). (unav.edu)
- PMID 6991092 , 1980 (No abstract) - "A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. (wikibooks.org)
- PMID 6286087 (no abstract) - "Impact of irradiation technique and tumor extent in tumor control and survival of patients with unresectable non-oat cell carcinoma of the lung: report by the Radiation Therapy Oncology Group. (wikibooks.org)
- Nek1 knockdown (KD) sensitized both cell lines to ionizing radiation following a single dose irradiation and more pronounced in combination with a 6 h fractionation (3 × 2 Gy) regime. (uni-frankfurt.de)
- Methods and Materials: Between 2004 and 2007, a total of 90 patients with locoregionally advanced head-and-neck squamous cell carcinoma underwent irradiation according to a hybrid fractionation schedule consisting of 20 fractions of 2 Gy (once daily) followed by 20 fractions of 1.6 Gy (twice daily) to a total dose of 72 Gy. (thavornthanasarn.com)
- Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial. (srobf.cz)
- IMRT permits the use of different total doses and different doses/fraction to different volumes within the irradiation field, utilizing the "simultaneous integrated boost" (SIB) technique. (scirp.org)
- An innovative technology is used to produce more uniform dose distribution with the same main goals : to intensify the irradiation on the tumour target and to alleviate the surrounding toxicity. (prostatherapy.com)
Radiotherapy57
- Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
- The first 45 patients in this series received carboplatin (70 mg/m²) on days 1 to 5 and 29 to 33 of radiotherapy. (cancernetwork.com)
- The next 31 patients received carboplatin at the same dose on days 1 to 5, 15 to 19, 29 to 33, and 43 to 47 of radiotherapy. (cancernetwork.com)
- Background/Aim: Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. (iiarjournals.org)
- The majority of patients with small-cell lung cancer (SCLC) receive radiotherapy in combination with chemotherapy. (iiarjournals.org)
- Also, many patients with locally advanced non-small-cell lung cancer (NSCLC) receive radiotherapy, if they are not candidates for surgery. (iiarjournals.org)
- Major goals of radiotherapy include local disease control and improvement of the patients' overall prognoses ( 2 ). (iiarjournals.org)
- These patients would require a closer monitoring during the course of radiotherapy and several months following treatment. (iiarjournals.org)
- Patients received conventionally fractionated radiotherapy of 5×2 Gy per week (on 5 consecutive days). (iiarjournals.org)
- In these patients developing pneumonitis following radiotherapy, clinical and treatment characteristics were analyzed to detect potential risk factors for this treatment-related complication. (iiarjournals.org)
- In addition, time to progression (local and/or distant failure) was evaluated in the patients developing pneumonitis, which was calculated from the end of radiotherapy. (iiarjournals.org)
- Integration of radiotherapy in multimodal tumor treatments is not to be challenged since above half of the tumor patients do receive it during their diseases history. (frontiersin.org)
- Further, it has been proven that locally applied radiotherapy does not destroy the immune system in a way that additional immunotherapy is not feasible. (frontiersin.org)
- demonstrate for the first time in pre-clinical model systems that radiotherapy can be combined with vaccination with syngeneic whole-tumor cell vaccine generated by high hydrostatic pressure, mimicking in cancer patients autologous vaccine from their own tumor cells. (frontiersin.org)
- Radiotherapy for acute metastatic epidural spinal cord compression (MESCC) involves conventional techniques and dose fractionation schemes, as it needs to be initiated quickly. (hindawi.com)
- Image-guided three-dimensional conformal radiotherapy (IG-3DCRT) was started with 25 Gy in 5 fractions followed by a boost of 12 Gy in 3 fractions, for which a field-in-field (FIF) technique was used to optimize the dose distribution. (hindawi.com)
- This case demonstrates that image-guided FIF radiotherapy with a dose-escalated hypofractionated regimen can potentially improve functional outcome and local control. (hindawi.com)
- Patients who are paraplegic before radiotherapy rarely regain ambulation, and this in turn can lead to a number of health problems related to immobility [ 2 ]. (hindawi.com)
- Furthermore, a field-in-field (FIF) technique has been applied to three-dimensional conformal radiotherapy (3DCRT) for various indications to amend dose distribution [ 5 , 6 ]. (hindawi.com)
- The purpose of this work was to evaluate the potential of functional imaging with 18 F-FDG PET, 18 F-fluoromisonidazole PET, diffusion-weighted MRI, and dynamic contrast-enhanced MRI to provide an appropriate and reliable biologic target for dose painting in radiotherapy for head and neck squamous cell carcinoma (HNSCC). (snmjournals.org)
- These results confirm the added value of 18 F-FDG PET and 18 F-fluoromisonidazole PET for radiotherapy planning of HNSCC and suggest the potential of diffusion-weighted and dynamic enhanced MRI for dose painting and early response assessment. (snmjournals.org)
- As intensity-modulated radiotherapy permits lowering the dose to the organs at risk outside the target volume, the maximum dose becomes restricted by the presence of dose-limiting structures within the target volume, such as cartilage, connective tissue, nerves, and bone. (snmjournals.org)
- The goal of definitive radiotherapy is to eradicate intra-thoracic disease while respecting the radiation tolerance of nearby normal structures by minimizing the dose to such structures. (cancernetwork.com)
- 3-6] Most innovative techniques have focused on conformal treatment delivery with computer assisted three-dimensional therapy planning and, in some cases, intensity-modulated radiotherapy in which more complex treatment planning and delivery can allow the radiation oncologist to have better control of doses to healthy tissues. (cancernetwork.com)
- A retrospective analysis was done for 130 patients with locally advanced NSCLC treated with curative radiotherapy alone or induction chemo-radiotherapy from January 1986 to October 1996. (e-roj.org)
- Eighty-five patients were treated with radiotherapy alone, forty-five with induction chemotherapy and radiotherapy. (e-roj.org)
- But, in patients with CR to overall treatment, distant metastasis were found in 11/19 patients with radiotherapy alone, and 3/13 patients with induction chemotherapy and radiotherapy (p=0.07). (e-roj.org)
- Specific areas of interest and expertise include CyberKnife® stereotactic radiosurgery, Image guided radiotherapy (IGRT), Intensity modulated radiotherapy (IMRT) for treatment of prostate, breast, pancreas, gastro-intestinal, brain tumors and SpaceOar for selected prostate cancer patients. (mygenesishealth.com)
- 2005 PMID 15667949 - "Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. (wikibooks.org)
- PMID 3032394 - "Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy. (wikibooks.org)
- Title:- Comparative Study of Concurrent Chemoradiotherapy Vs Only Radiotherapy in Locally Advanced Carcinoma Cervix to Asses the Clinical Outcome & Toxicity of Patients in Our Clinical Setting. (gov.bd)
- Title:-Comparative Study on Conventional Fractionation Throughout Vs. Initial Large Doses Followed by Conventional Fractionated Radiotherapy in The Management of Superior Vena Cava Obstruction Syndrome. (gov.bd)
- Title:- Comparative Study of Hypofractioned Palliative Radiotherapy (17 GY in 2 Fractions) with Conventional Fractionation (30 GY in 10 Fractions) in Inoperable Locally Advanced Non-Small Cell Lung Cancer in Terms of Symptom Control and Toxicities. (gov.bd)
- Title:-Comparative Evaluation of Toxicity and Response in Split Course Hypo-Fractionated Radiotherapy and Conventional Radiotherapy in Locally Advanced Head & Neck Cancer in Patients with Poor Performance Status. (gov.bd)
- Title:-Comparative Study of Two Hypofractionated Palliative Radiotherapy Schedule (24 GY/3 Frractions Vs. 30 GY/10 Fractions) in Locally Advanced Head Neck Cancer. (gov.bd)
- Purpose: To evaluate the feasibility and efficacy of a hyperfractionated accelerated radiotherapy (RT) schedule combined with concomitant chemotherapy (Cx) in patients with locally advanced head-and-neck squamous cell carcinoma. (thavornthanasarn.com)
- Herein, we examine treatment patterns and survival of cervical cancer patients treated in Tikur Anbessa Hospital Radiotherapy Center (TAHRC), the only hospital with radiotherapy facility in the country. (biomedcentral.com)
- Stage migration occurred in 13% of patients while waiting for radiotherapy. (biomedcentral.com)
- Consequently, the proportion of patients with stage III or IV disease increased from 66% at first consultation to 74% at the initiation of radiotherapy. (biomedcentral.com)
- Among 151 patients treated with curative intent, only 34 (22.5%) of the patients received concurrent chemotherapy while the reaming patients received radiotherapy alone. (biomedcentral.com)
- As expected, survival was lower in patients with advanced stage at initiation of radiotherapy and in those treated as palliative care. (biomedcentral.com)
- The survival of cervical cancer patients remains low in Ethiopia because of late presentation and delay in receipt of radiotherapy, leading to stage migration in substantial proportion of the cases. (biomedcentral.com)
- Patients with cervical cancer were referred from all over Ethiopia to Tikur Anbessa Hospital Radiotherapy center for radiotherapy. (biomedcentral.com)
- Discussion We expect the program to provide more information of neoadjuvant radiotherapy and/or chemotherapy on anorectal function, and to optimize the treatment strategy to reduce anorectal dysfunction for LARC patients. (sagepub.com)
- The era of orthovoltage radiotherapy (RT) and the Ralston Paterson "school of radiation dose delivery" [1] lasted for over 6 0 year s. (viamedica.pl)
- During these years radiotherapy planning was relatively simple: based on X - ray radiographs and 2D - coplanar, geometrically regular, well - shaped 2 - 6 beams focused on the tumor (fig. 1), whilst dose distribution was calculated based on diagrams of the percentage depth isodose s. (viamedica.pl)
- Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. (srobf.cz)
- High-dose radiotherapy with short-term or long-term androgen deprivation in localised prostate cancer (DART01/05 GICOR): a randomised, controlled, phase 3 trial. (srobf.cz)
- Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial. (srobf.cz)
- No Increased Risk of Second Cancer After Radiotherapy in Patients Treated for Rectal or Endometrial Cancer in the Randomized TME, PORTEC-1, and PORTEC-2 Trials. (srobf.cz)
- Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of thehead and neck: 10-year update and subset analysis. (srobf.cz)
- Patients often can't travel far for treatment or afford to stay near a treatment center for the length of time required for conventionally fractionated radiotherapy. (medscape.com)
- A hypofractionated radiotherapy regimen with or without weekly cisplatin may be a viable alternative for patients with locally advanced head and neck cancer in these settings. (medscape.com)
- Dose escalation has been proposed to improve local control [2] -[5] and capitalize on the therapeutic ratio of thoracic radiotherapy, which is mainly limited by the potential toxicity to organs at risk (OARs). (scirp.org)
- Patients at high risk for tumor recurrence may benefit from more aggressive altered fractionation schedules in order to reduce the overall time from surgery to completion of radiotherapy. (biomedcentral.com)
- In the six trials of interest, a total of 988 patients with locally advanced HNSCC were randomly assigned to receive either accelerated or conventionally fractionated adjuvant radiotherapy. (biomedcentral.com)
- Accelerated radiotherapy does not result in a significant improvement of loco-regional control or overall survival in high-risk patients. (biomedcentral.com)
Conventional9
- More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
- By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
- All patients had definitive radiochemotherapy with a conventional fractionation, linear accelerator using single doses of 2 Gy to a whole dose of 60 Gy to the primary tumor and cervical nodes, with a boost to 70 Gy for sites of tumor. (cancernetwork.com)
- Conventional fractionation with daily fraction size 1.8~2.0 Gy was done. (e-roj.org)
- Title:-A Comparative study of thyroid function status in head and neck cancer patient treated with conventional (2D) Vs CT based conformal (3D) treatment at NICRH. (gov.bd)
- The phase 3 randomized HYPNO trial, conducted in 10 low- and middle-income countries, revealed that the hypofractionated regimen shortened total treatment time by a median of 11.5 days and was noninferior to conventional fractionation for tumor control and safety. (medscape.com)
- Compliance with the regimens was high in both arms, with 95% of patients assigned to conventional fractionation and 99% assigned to hypofractionation receiving the total planned doses. (medscape.com)
- At 3 years' follow-up, the rates of locoregional control were 50.7% in the hypofractionation arm and 51.2% in the conventional fractionation arm ( P = .40). (medscape.com)
- Rates of late toxicities of grade 3 or greater at 3 years' follow-up were similar between the groups, at 18.8% in the hypofractionation arm and 20.2% in the conventional fractionation arm ( P = .68). (medscape.com)
Tumor control5
- This patient was treated with image-guided 3DCRT (IG-3DCRT) alone using a FIF technique and a unique hypofractionated dose fractionation scheme, which resulted in good tumor control and sufficient cord decompression, which in turn allowed a delayed but gradual improvement in her severe neurological dysfunction. (hindawi.com)
- Another promising application is the introduction of dose escalation to improve tumor control. (snmjournals.org)
- 7-8] Here, the goal has been to deliver higher doses to target volumes in an effort to improve local tumor control within the constraints of surrounding regions of normal tissues such as the heart, lung, esophagus, and spinal cord. (cancernetwork.com)
- Tumor control rates with photon radiation therapy, however, continue to be disappointing, in part because of the dose-limiting constraints associated with these normal structures. (cancernetwork.com)
- The DVHs for the PTV and organs at risk were analyzed using a Biosuite algorithm to calculate the equivalent uniform dose (EUD), tumor control probability (TCP) via a Poisson model, and normal tissue complication probability (NTCP) via an LKB model. (scirp.org)
Escalation15
- Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
- Though initial studies showed a benefit to dose escalation, phase III studies examining dose escalation using standard fractionation or hyperfractionation have failed to show a benefit. (frontiersin.org)
- It was therefore suggested that dose escalation should be targeted to areas of increased radioresistance in the tumor ( 1 ). (snmjournals.org)
- Results from several trials suggest that pretreatment 18 F-FDG uptake correlates with outcome in HNSCC patients and can therefore indicate a valuable target for dose escalation ( 7 , 8 ). (snmjournals.org)
- Various photon radiation techniques have been tried in order to effect a therapeutic advantage, among them hyperfractionation (multiple treatments per day), accelerated fractionation (shorter treatment periods), and dose escalation. (cancernetwork.com)
- RTOG Review PMID 16015546 -- "A review of radiation dose escalation trials for non-small cell lung cancer within the Radiation Therapy Oncology Group. (wikibooks.org)
- Phase I/II dose escalation. (wikibooks.org)
- Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)
- Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
- An ongoing GETUG-AFU-18 phase III trial is evaluating the impact of dose escalation in combination with 3-year androgen deprivation treatment on 5-year biochemical or clinical control in high-risk prostate cancer patients [8]. (scirp.org)
- Dose escalation can be achieved with either 3-Dimensional Conformal Radiation Therapy (3-DCRT) or with intensity-modulated Radiation Therapy (IMRT). (scirp.org)
- However, in the context of dose escalation to the prostate, dosimetric and clinical results from the literature comparing WP IMRT with PO IMRT are still limited. (scirp.org)
- However, SBRT confronts several issues including patient positioning, breathing patterns, and high dose escalation. (scirp.org)
- The main advantage of the 3D-CRT is the possibility of a dose escalation without increase in normal tissue toxicity. (prostatherapy.com)
- By using more than 9 angles beams and thousands of segments, it allows a higher dose escalation to the most aggressive cancer cells (picture 44). (prostatherapy.com)
Chemotherapy16
- The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
- However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
- Seventeen patients (81.0%) received chemotherapy and/or immunotherapy, 12 (57.1%) had significant cardiovascular disease (all 21 patients had risk factors), 11 (52.4%) were heavy smokers (≥40 pack years), 7 (33.3%) were aged ≥74 years, 5 (23.8%) had chronic inflammatory disease and 4 (19.0%) had previous tumors. (iiarjournals.org)
- Patients received a total radiation dose of 4760 cGy, delivered twice daily during chemotherapy. (onclive.com)
- Chemotherapy consisted of weekly cisplatin at a dose of 40 mg/m2. (onclive.com)
- The patient initially underwent 4 courses of systemic chemotherapy that consisted of cisplatin and gemcitabine, resulting in a partial response, but the disease subsequently progressed. (hindawi.com)
- 7 reported a 76% reduction in the number of patients referred for a possible cancer diagnosis and a 60% reduction in chemotherapy treatments compared to pre-COVID-19 levels. (ilcn.org)
- We performed this study to evaluate the prognostic factors and the effect of induction chemotherapy in locally advanced non-small cell lung cancer (NSCLC). (e-roj.org)
- At least in CR patients, there was decreased tendency in distant metastasis with induction chemotherapy. (e-roj.org)
- 2 In the 1990s, improvements in survival were made with the addition of concurrent chemotherapy to RT, 3,4 with no patients alive at 3 years in the RT-alone arm. (appliedradiationoncology.com)
- Patients were randomized to induction chemotherapy (5-FU, leucovorin, etoposide and cisplatin) followed by CRT (40 Gy) and surgical resection or induction chemotherapy (5-FU, leucovorin, etoposide and cisplatin) followed by CRT (at least 65 Gy) without surgical resection. (appliedradiationoncology.com)
- 8-13 Walsh et al evaluated outcomes of esophageal adenocarcinoma (AC) patients treated with 40 Gy in 15 fractions of RT combined with cisplatin and 5-fluorouracil (5-FU) chemotherapy followed by surgical resection compared with surgical resection alone. (appliedradiationoncology.com)
- Over the decades Dr. Morrison has been involved in trials of fractionation, radiation protectors, induction and concurrent chemotherapy, and proton beam therapy. (mdanderson.org)
- After screening for eligibility and obtaining informed consent, a total of 402 LARC patients undergoing NCRT followed by surgery, or neoadjuvant chemotherapy followed by surgery, or surgery only would be included in the trial. (sagepub.com)
- Patients who have had chemotherapy or radiation therapy for breast cancer or other malignancies have a greater likelihood of developing angiosarcoma in the radiated area. (klarity.health)
- After stratification by performance status, tumor subsite, institution, and previous treatment with chemotherapy, the 792 patients in the trial were randomly assigned in a 1:1 ratio to receive either 66 Gy in 33 fractions 6 days each week over 5.5 weeks, or 55 Gy in 20 fractions 5 days per week over 4 weeks. (medscape.com)
Squamous-cell carc10
- The trial enrolled 76 consecutive patients (mean age 55 years) with unresectable locally advanced squamous-cell carcinoma without distant metastases. (cancernetwork.com)
- Although there is still considerable room for improvement, the results of GOG 205 would indicate that this is a reasonable standard for [the] treatment of locally advanced squamous cell carcinoma of the vulva and should be the treatment program for future comparisons in prospective trials," said David H. Moore, MD, a gynecologic oncologist at the St. Francis Medical Group in Indianapolis, Indiana. (onclive.com)
- Although there is still considerable room for improvement, the results of GOG 205 would indicate that this is a reasonable standard for [the] treatment of locally advanced squamous cell carcinoma of the vulva and should be the treatment program for future comparisons in prospective trials. (onclive.com)
- A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
- The German Esophageal Study Group performed a phase III trial comparing definitive CRT to preoperative CRT followed by resection in locally advanced squamous cell carcinoma of the esophagus. (appliedradiationoncology.com)
- Here, we report the association of Polo-like kinase (PLK) 3 expression and Caspase 8 T273 phosphorylation levels with survival among patients with cervical squamous cell carcinoma (CSCC) treated with CRT plus BT. (uni-frankfurt.de)
- Methods: We identified 74 patients with FIGO Stage Ib to IVb cervix squamous cell carcinoma. (uni-frankfurt.de)
- Title:-Weekly Cisplatin vs. Three-weekly Cisplatin in Concurrent Chemoradiotherapy of Locally Advanced Head and Neck Squamous Cell Carcinoma-Evaluation of Short Term Response and Toxicity. (gov.bd)
- Long-term results of radiation therapy oncology group 9903: a randomized phase 3 trial to assess the effect of erythropoietin on local-regional control in anemic patients treated with radiation therapy for squamous cell carcinoma of the head and neck. (srobf.cz)
- This study sought to investigate the efficacy and safety of a three-drug combination antiemetic regimen of olanzapine combined with aprepitant and palonosetron for the prevention of chemoradiotherapy-induced nausea and vomiting in locally advanced head and neck squamous cell carcinoma. (centerwatch.com)
Radiation therapy17
- An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
- Even at 2 years after radiation therapy, 15% of patients had grade 2 swallowing dysfunction and 8% had progressive dysphagia, so their swallowing is going to continue to get worse. (ascopost.com)
- Proton radiation for cancer offers the ability to conform the high-dose region of radiation therapy to the tumor while reducing the dose of radiation to adjacent normal tissues. (cancernetwork.com)
- Over half of cancer patients undergo radiation therapy (RT). (nature.com)
- VA Lung Group (VALG) PMID 4170866 -- "The survival of patients with inoperable lung cancer: a large-scale randomized study of radiation therapy versus placebo. (wikibooks.org)
- Initial studies comparing surgery to radiation therapy (RT) showed high operative mortality in surgical patients, and poor survival in both the surgical and radiation-alone patients. (appliedradiationoncology.com)
- He has personally treated 3200 head and neck patients, and gained leading technical expertise and judgement in the formulation and delivery of radiation therapy. (mdanderson.org)
- Approximately 75% of HNSCC patients receive radiation therapy (RT) as standard of care for disease ranging from early to locally advanced [ 2 ]. (biomedcentral.com)
- Phase 3 trials of stereotactic radiosurgery with or without whole-brain radiation therapy for 1 to 4 brain metastases: individual patient data meta-analysis. (srobf.cz)
- Hyperfractionated accelerated radiation therapy (HART) of 70.6 Gy with concurrent 5-FU/Mitomycin C is superior to HART of 77.6 Gy alone in locally advanced head and neck cancer: long-term results of the ARO 95-06 randomized phase III trial. (srobf.cz)
- The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
- Androgen deprivation therapy (ADT) was given for all patients before and during radiation therapy. (scirp.org)
- In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
- This is a trial that directly informs how you can effectively deliver radiation therapy to patients in a resource-scarce environment. (medscape.com)
- Purpose: Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment moda- lity for medically inoperable early-stage lung cancer patients. (scirp.org)
- Stereotactic body radiation therapy (SBRT) is a technique that can attain a high cumulative biologically effective dose (BED) inside the tumor with a steep gradient outside the tumor, preventing dose to OARs. (scirp.org)
- In clinical practice accelerated postoperative radiation therapy might be a suitable option only for a subset of patients. (biomedcentral.com)
Organs6
- In studies spanning more than four decades, Rubin and several collaborators identified the clinicopathologic courses of radiation injury in organs and tissues throughout the body and identified tolerance doses for those organs. (cancernetwork.com)
- Therefore, consecutive-IMRT/VMAT may be more appropriate than SIB-IMRT/VMAT when the fraction doses to the critical organs or target volumes are the major concern. (onkder.org)
- Drawing the dose volume histograms (DVHs) was done for planning target volumes (PTVs), including Prostate PTV & nodal PTV, and organs at risk including rectum, bladder, femoral heads, and bowel bag for the plans. (scirp.org)
- The DVH analysis showed good coverage of PTVs and organs at risk doses were acceptable. (scirp.org)
- We calculate dose volume histograms (DVHs) of targeted tumors and organs at risk for 39 patients. (scirp.org)
- Due to the low conformity of these treatments, adjacent tissues/organs often fall into the high dose region resulting in treatment side effects. (prostatherapy.com)
Different doses2
- 1 - 3 ] In addition, with the simultaneous integrated boost (SIB) technique, different doses can be applied to multiple targets simultaneously with high conformity in IMRT/VMAT plans. (onkder.org)
- Consequently, the IMRT-SIB technique allows different doses to the prostatic area and the pelvic lymph nodes. (scirp.org)
Toxicity5
- Our patients are asking us to do better and reduce toxicity. (ascopost.com)
- An estimated 80% of patients will have grade 3 toxicity with current treatments, and up to 25% to 60% will "continue to suffer from grade 3 toxicity. (ascopost.com)
- Late dose-limiting toxicity at 90.3 Gy level. (wikibooks.org)
- We will additionally review the current and past technologies for radiation treatment delivery, and their impact on overall survival and toxicity in this patient cohort. (appliedradiationoncology.com)
- Dose limitations are uniquely challenging in HNSCC due to the proximity of critical OARs with early and late toxicity resulting in mucositis, dysphagia, xerostomia, tooth decay, vocal dysfunction and loss of taste [ 11 ]. (biomedcentral.com)
Chemoradiation3
- That compared with 48% of patients who had no gross residual disease in the Gynecologic Oncology Group (GOG) 101 trial, which established a widely used chemoradiation regimen. (onclive.com)
- 7 Responders proceeded to surgical resection while nonresponders completed chemoradiation to a total dose of either 66 Gy in 33 fractions (standard fractionation) or 45 Gy in 15 fractions (for the hypofractionated arm). (appliedradiationoncology.com)
- Introduction: Definitive chemoradiation (CRT) followed by high-dose-rate (HDR) brachytherapy (BT) represents state-of-the-art treatment for locally-advanced cervical cancer. (uni-frankfurt.de)
Metastases5
- Patients with locally advanced disease who had distant metastases were also included. (iiarjournals.org)
- A single fraction for all, or an argument for fractionation tailored to fit the needs of each individual patient with bone metastases? (mcmaster.ca)
- An 85-year-old woman presented with epigastric discomfort and was clinically diagnosed with locally advanced unresectable carcinoma of the gallbladder associated with liver metastases. (hindawi.com)
- The only NSCLC subgroup that has a better than 50% five-year survival is that comprised of patients with peripherally located T1 or T2 tumors without evidence of nodal or distant metastases. (cancernetwork.com)
- The potential for improved outcome in patients with hepatic metastases from colon cancer: A population-based study. (cancercentrum.se)
Median6
- Subgroup analysis stratified according to tumor volume showed that patients with tumors smaller than 20 cm³ had better response with the intensified regimen, especially in overall survival (median 22 months vs 15 months) and in time to progression (median 17 months vs 10 months). (cancernetwork.com)
- Results: Pneumonitis was diagnosed in 21 patients (7.6%) after a median of 9 (1-23) weeks. (iiarjournals.org)
- We have seen a significant increase in the incidence of HPV-associated oropharyngeal cancer in relatively younger patients, with the median age of diagnosis in the 50s, even patients in their 30s," Dr. Agrawal said. (ascopost.com)
- Of the patients, 129 patients received total dose above 59.6 Gy (56~66 Gy, median 60 Gy). (e-roj.org)
- Overall 1-, 2-, and 3-year survival rate (YSR) for all patients were 41.5%, 13.7%, and 7%, respectively (median survival time 11 months). (e-roj.org)
- Among 242 patients included in the study, the median age at diagnosis was 48 years. (biomedcentral.com)
Fraction5
- These encouraging results are interpreted as being attributable to utmost precision in dose delivery (by avoiding a 'geographic and/or temporal miss'), and the possible radiobiological superiority of a single high dose fraction, compared to the conventionally fractionated boost. (unav.edu)
- However, if there is a heterogeneous dose distribution in phase1 planning, there may be very low or very high fraction doses within the target volume only in phase2 planning. (onkder.org)
- However, in the SIB technique, the fraction doses in the target and boost volumes may be lower or higher than the normal fractionation, and the critical organ fraction doses may be higher. (onkder.org)
- Seminal vesicle (PTV56) and Prostate (PTV78) volumes must be irradiated radiobiologically with a dose of 1.8-2.0 Gy per fraction. (onkder.org)
- It has been proven that 1.8-2.0 Gy fraction doses and 76?80 Gy total doses reduce the biochemical failure rates. (onkder.org)
Tumors2
- While low radiation doses mostly seem to enhance immune cell infiltration into tumors, higher doses do induce immunogenic cancer cell death, and create an immune stimulatory micro-environment for the attracted immune cells. (frontiersin.org)
- Clinical experience confirms the feasibility of proton radiation for early-stage non-small-cell lung cancers, and clinical trials are being conducted in locally advanced tumors: To date, evidence indicates that proton radiation should be further explored. (cancernetwork.com)
Clinical10
- About two-thirds of patients had clinical complete responses and more than half had no evidence of disease on pathologic examination. (onclive.com)
- Additionally, 37 (64%) of the patients had clinical complete responses. (onclive.com)
- A retrospective analysis 4 of 323 patients with advanced oropharyngeal squamous cell cancer enrolled in a randomized clinical trial found a 3-year overall survival rate of 82.4% for HPV-associated disease vs 57.1% for HPV-negative disease, and progression-free survival of 73.7% vs 43.4%, Dr. Agrawal reported. (ascopost.com)
- I have recently shown that synovial tissue poly-T-cells can predict RA-patient stratification, correlate with disease progression in RA and PsA and importantly, are present at the joints of at risk-individuals prior to development of clinical-inflammation. (dcu.ie)
- In addition, we correlated Nek1 expression in biopsies of patients with cervical cancer with histopathological parameters and clinical follow-up. (uni-frankfurt.de)
- Title:-Clinical Response of CCRT with Temozolomide versus RT Alone in Patients with High Grade Gliomas. (gov.bd)
- Dr. William Morrison is a Professor of Radiation Oncology at M.D. Anderson Cancer Center, with 31 years of clinical experience treating patients with head and neck cancer. (mdanderson.org)
- Information about clinical characteristics and treatments were extracted from the patients' medical record files. (biomedcentral.com)
- WHO's international standards are used to calibrate regional, national or manufacturers' standards and often form the basis for licensing, routine lot release and clinical dosing worldwide. (who.int)
- The purpose of present study was to compare the dosimetric difference and elucidate the dosimetric quality of the radiotherapeutic plans between synchronous and composite planning approaches in consecutive- VMAT for prostate CA. In addition, it was aimed to evaluate the differences in target and critical organ doses of the two approaches in terms of clinical results. (onkder.org)
Survival3
- Significant hypoxia was present in 58 patients (79%), and both the degree of hypoxia and the size of the hypoxic volume were independent predictive factors for survival ( 10 ). (snmjournals.org)
- Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)
- Modern SBRT has yielded durable local control results, comparable to surgery [9] , and excellent overall survival outcomes even in inoperable patients. (scirp.org)
Chemoradiotherapy4
- Fifteen patients with locally advanced HNSCC, treated with concomitant chemoradiotherapy, were prospectively enrolled in a bioimaging protocol. (snmjournals.org)
- Fan, Xin-Juan 2023-05-22 00:00:00 Background Neoadjuvant chemoradiotherapy (NCRT ) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). (sagepub.com)
- BMC Cancer (2023) 23:467 Page 2 of 7 Keywords Anorectal function, Locally advanced rectal cancer, Neoadjuvant chemoradiotherapy, Total mesorectal excision, Sphincter preservation treatments Introduction and Wexner continence score or LARS score after differ - Background and rationale ent treatment regimens would be investigated. (sagepub.com)
- After providing written informed consent, these adjuvant chemoradiotherapy (NCRT) is being used in patients will undergo sphincter-preserving therapies patients with LARC (T3-T4 or N0-N1), with the pur- including either NCRT with surgery, or NCT with sur- pose of reducing the local recurrence rates and increas- gery or surgery only. (sagepub.com)
Recurrence4
- For patients at low risk for in-breast recurrence (ASTRO/ESTRO recommendations), full dose IOERT was isoeffective with standard WBI. (unav.edu)
- Most recurrence occurs locally and within the first year after treatment. (wikipedia.org)
- As a result, patients are monitored regularly for signs or symptoms of recurrence. (cancer.gov)
- However between the subgroups of altered fractionation only the hyperfractionated, and not the accelerated, schedules appear to provide a substantial mortality benefit beyond a reduction in local recurrence [ 14 ]. (biomedcentral.com)
SBRT2
- The aim of this paper is to calculate radiobiological parameters for a sample of 39 patients who underwent lung SBRT. (scirp.org)
- Several authors have carried out studies on lung SBRT, examining the impacts of beam arrangement, image guidance, radiation dose constraints, dose prescription, and treatment planning algorithm on patient outcomes. (scirp.org)
Metastatic4
- Stage III lung cancer, though heterogeneous in its classification, includes non-metastatic but locally advanced disease with involvement of N1-N3 nodal stations and/or T3 and T4 primaries. (frontiersin.org)
- Metastatic epidural spinal cord compression (MESCC) is a common neurological complication of cancer and can have devastating consequences for patients [ 1 - 3 ]. (hindawi.com)
- 1] Non-small-cell lung cancers (NSCLCs) predominate over the small-cell variant of lung cancer, and are usually associated with a poor prognosis, owing to locally advanced or metastatic presentations. (cancernetwork.com)
- In the age of molecularly-targeted drugs and immunotherapy, the best treatment option for advanced and metastatic patients, which is the majority, remain combinations of cytotoxic drugs. (mdpi.com)
Lung cancer6
- Patients and Methods: This study included 278 patients irradiated for locally advanced lung cancer between 2016 and 2019. (iiarjournals.org)
- Therefore, this study was performed aiming to identify the prevalence of pneumonitis and potential risk factors for this complication in patients with locally advanced lung cancer irradiated with volume-modulated arc therapy (VMAT). (iiarjournals.org)
- In this retrospective study, which was approved by the ethics committee of the University of Lübeck, 278 patients irradiated for locally advanced lung cancer between 2016 and 2019 were evaluated with respect to the development of symptomatic (grade ≥2) pneumonitis. (iiarjournals.org)
- An 89-year-old patient with gallbladder neuroendocrine neoplasms (GB-NENs) and lung cancer metastasis underwent nivolumab monotherapy, resulting in tumor shrinkage. (bvsalud.org)
- Published studies on COVID-19 and cancer show that patients with active neoplasms have a higher risk of severe complications and mortality from SARS-CoV-2 infection than the general population, particularly those with lung cancer, on myeloid suppressive treatments, and/or with advanced age, compromise of their functional status, or comorbidities. (ilcn.org)
- Studies that compare the distribution of radiation doses for lung cancer show that proton radiation is superior, even when factors such as respiratory motion are considered. (cancernetwork.com)
VMAT5
- For three locoregionally advanced oropharyngeal carcinomas and one adenoid cystic carcinoma, mean dose to the contralateral salivary glands, pharynx and oral cavity was reduced by 2.5, 1.7 and 3.1 Gy respectively on average with DTRT compared to VMAT. (biomedcentral.com)
- For a locally recurrent nasopharyngeal carcinoma, D 0.03 cc to the ipsilateral optic nerve was above tolerance (54.0 Gy) for VMAT (54.8 Gy) but within tolerance for DTRT (53.3 Gy). (biomedcentral.com)
- For a laryngeal carcinoma, DTRT resulted in higher dose than VMAT to the pharynx and brachial plexus but lower dose to the upper oesophagus, thyroid gland and contralateral carotid artery. (biomedcentral.com)
- One important advantage of the IMRT/VMAT techniques is the ability to shape dose distributions, thus avoiding nearby critical structures such as bladder and rectum. (onkder.org)
- The optimization of the boost plan would be adjusted based on dose distributions of the phase1 VMAT/IMRT plan. (onkder.org)
Rabies3
- The Expert Committee recommended adoption of guidelines for DNA vaccines and rotavirus vaccines, and advised that recommendations should be adopted for whole-cell, pertussis vaccine, human plasma for fractionation and rabies vaccine. (who.int)
- The vaccine grown on WI-38 cells and developed in the United States is inactivated with tri-n-butyl phosphate and B-propiolactone (Wyeth Laboratories' WYVAC(R)), while that grown in MRC-5 cells and developed in Europe is inactivated with B-propiolactone (Merieux Institute's RABIES VACCINE(R)). Both vaccines are supplied as 1.0 ml, single-dose vials of lyophilized vaccine with accompanying diluent. (cdc.gov)
- Rabies Immune Globulin, Human (RIG): RIG (Cutter Laboratories' HYPERAB(R) and Merieux Institutes' IMOGAM(R)) is antirabies gamma globulin concentrated by cold ethanol fractionation from plasma of hyperimmunized human donors. (cdc.gov)
Treatment27
- Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
- In patients experiencing symptomatic pneumonitis, patient and treatment characteristics were analyzed. (iiarjournals.org)
- Frequent characteristics included high mean lung doses, systemic treatment, cardiovascular disease (and risk factors), heavy smoking, older age, chronic inflammatory disease and history of a previous tumor. (iiarjournals.org)
- Therefore, it would be desirable to identify patients, who are at high risk of developing radiation pneumonitis, prior to the start of treatment. (iiarjournals.org)
- Treatment characteristics included mean dose to the ipsilateral lung and type of systemic treatment. (iiarjournals.org)
- According to the World Health Organization, in low-income and high-income countries, fewer than 30% and more than 90% of patients diagnosed with cancer have access to treatment, respectively. (ilcn.org)
- The impact of public health measures to contain the pandemic is interwoven with the changes in habits, and healthy behaviors as well as the consequences of the economic crisis, all of which increase poverty and create challenges for patients in accessing cancer screening and treatment promptly. (ilcn.org)
- Hence, several national guidelines now include this treatment strategy as one of the standard techniques for PBI in carefully selected patients. (unav.edu)
- This treatment method allows high-dose areas to be conformed tightly to the target volumes, with dose falling off steeply outside these regions. (snmjournals.org)
- Functional imaging, that is, modalities that offer information on factors that influence treatment outcome (e.g., tumor burden, proliferation, and hypoxia), is expected to provide the biologic target volume for such dose painting ( 2 , 3 ). (snmjournals.org)
- This ability to spare normal tissues is an important consideration: The greater the extent to which the physician can reduce or eliminate the radiation dose to normal tissues, the lesser the likelihood that treatment will need to be compromised because of unacceptable side effects. (cancernetwork.com)
- In the absence of high quality evidence regarding which treatment provides the best outcomes, management decisions are often based on one or more of the following: technical factors, likely functional loss, and patient preference. (wikipedia.org)
- Furthermore it is impossible to predict who will develop severe, erosive disease or who will respond to treatment thus patients are subjected to several rounds of "exploratory" treatments until the right treatment is identified. (dcu.ie)
- 9 Similarly, the European Organization for Research and Treatment of Cancer (EORTC) trial 8 randomized SCC patients to surgery alone or neoadjuvant CRT consisting of two 1-week courses of RT, separated by a 2-week break, to a total dose of 37 Gy in 10 fractions with concurrent cisplatin. (appliedradiationoncology.com)
- Despite use of this treatment paradigm, disease-related outcomes have stagnated in recent years, indicating the need for biomarker development and improved patient stratification. (uni-frankfurt.de)
- Conclusion: Increased pre-treatment tumor levels of PLK3 and pT273 Caspase 8 correspond to improved disease-related outcomes among cervical cancer patients treated with CRT plus BT, representing a potential biomarker in this context. (uni-frankfurt.de)
- The development of high-resolution imaging for precise SRS treatment planning, paired with computing technology interacting with medical robots, has accelerated, increasing the accuracy of beam delivery techniques, helping to apply treatment doses with sub-millimeter accuracy. (mdpi.com)
- Treatment outcome and toxicitymore were retrospectively compared with a previous patient group (n = 73) treated with the same schedule, but without concomitant Cx, between 2001 and 2004. (thavornthanasarn.com)
- However, the number of cervical patients is continuously increasing from year to year, which makes the waiting time for receipt of radiation treatment to be very long [ 7 , 9 , 10 ]. (biomedcentral.com)
- Even if the defined dose is applied in total, hot or cold dose volumes can directly affect the radiobiological gain and the result of the treatment. (onkder.org)
- For high risk prostate cancer, the treatment volumes and even dose levels are still a controversial issue. (scirp.org)
- In the HYPNO trial, Bentzen and colleagues wanted to determine whether a streamlined approach to the treatment of patients in low- and middle-income countries could improve access to care and still achieve strong outcomes. (medscape.com)
- Although the approach used in the HYPNO trial will likely allow more patients to receive treatment and will save lives in countries with limited resources, the strategy likely won't apply to US practice, noted Beadle, a professor of radiation oncology at Stanford University, California. (medscape.com)
- All patients received 4D imaging, and their internal treatment volumes (ITVs) were created by phase-based sorting of multiple CT datasets. (scirp.org)
- Thirdly there are also economic and patient convenience arguments to shorten the overall treatment time on a linear accelerator time slot. (biomedcentral.com)
- Computational simulations of tumor growth and treatment response: Benefits of high-frequency, low-dose drug regimens and concurrent vascular normalization. (harvard.edu)
- Segelman J, Singnomklao T, Hellborg H, Martling A. Differences in MDT assessment and treatment between patients with stage IV colon and rectal cancer. (cancercentrum.se)
Brachytherapy1
- Title:- Comparative Study of Single Channel Versus Multiple Channel Miami Applicator for Postoperative Vaginal Brachytherapy by Measurement of Dose Distribution and Organ at Risk (OAR) Volume. (gov.bd)
Outcome2
- For both applications, the criteria for patient selection, technical details/requirements, physical aspects and outcome data are presented. (unav.edu)
- A population-based study on the management and outcome in patients with locally recurrent rectal cancer. (cancercentrum.se)
Radiochemotherapy3
- The pilot trial was a controlled phase II study involving 14 patients randomized to receive standard radiochemotherapy, with radiation administered in 2-Gy fractions to a total dose of 60 Gy plus carboplatin (Paraplatin) 70 mg/m² as a radiosensitizer weeks 1 and 5. (cancernetwork.com)
- This study was followed by a controlled, phase II dose-intensification study to evaluate the role of intensified carboplatin dosage with amifostine protection and concomitant radiochemotherapy in locally advanced pharyngeal cancer. (cancernetwork.com)
- Effects of neoadjuvant radiochemotherapy for anorectal function in locally advanced rectal cancer. (sagepub.com)
Rationale1
- The rationale stands on the relationship between radiation dose and cytotoxicity effect where a few large individual doses have more cell-killing effect than the same dose given gradually. (prostatherapy.com)
Recurrent1
- Patients who had Foundation Medicine sequencing data and received RT for primary or locally recurrent HNSCC were selected for this study. (biomedcentral.com)
Cisplatin1
- The FFCD 9102 trial randomized 444 patients with resectable esophageal cancer (majority squamous histology) to induction CRT consisting of either 46 Gy in 23 fractions with concurrent cisplatin and 5-FU or split course 30 Gy in 10 fractions RT given over 4 weeks (5 days on, 10 days off, 5 days on). (appliedradiationoncology.com)
Nasopharyngeal carcinoma1
- Concurrent chemo-radiation with or without induction gemcitabine, Carboplatin, and Paclitaxel: a randomized, phase 2/3 trial in locally advanced nasopharyngeal carcinoma. (srobf.cz)
Rectal cancer2
- Rectal cancer represents an important public health problem that compromises patients' health-related Methods quality of life. (sagepub.com)
- gold standard method in sphincter-preserving therapy The eligible patients will be informed about the study in for locally advanced rectal cancer (LARC) [2, 3]. (sagepub.com)
Total9
- In GOG 205, patients received a total radiation dose of 5760 cGy administered in single daily fractions. (onclive.com)
- They estimated that a delay per patient of 3 or 6 months would cause the attributable deaths of 4,755 and 10,760 patients, respectively, among the 80,406 long-term surviving patients (taken from the total number of patients operated on annually in the United Kingdom who have the most common invasive cancers in adults). (ilcn.org)
- In other words, the reduced lateral scatter and sharp dose fall-off of the proton beam not only allows delivery of the total needed dose but also affords opportunities to deliver higher doses without increasing side effects. (cancernetwork.com)
- In this review, we examine the role of trimodality therapy in the management of locally advanced esophageal cancer, focusing on controversies surrounding the optimal total neoadjuvant RT dose employed. (appliedradiationoncology.com)
- A total of HNSCC 37 patients were analyzed in this study. (biomedcentral.com)
- Currently, total mesorectal excision (TME) is the multicentre study of patients diagnosed with LARC. (sagepub.com)
- When the phase1+phase2 total dose distribution was evaluated, better results were obtained with CP. (onkder.org)
- Then, the plans of the two phases are directly summed to obtain the total dose distribution. (onkder.org)
- With these two approaches, different results can be found only in boost plans and total dose distributions. (onkder.org)
Target volumes1
- Because of their their mass (about 1800 times that of an electron) and charge, proton beams can be controlled in three dimensions so that radiation doses can be more accurately deposited within target volumes while the dose to surrounding non-targeted tissues is often minimized-or even eliminated. (cancernetwork.com)
Higher dose1
- The new trial, GOG 205, employed a higher dose of radiation but a less-intense fractionation schedule than used in GOG 101, according to details presented at the recent Society of Gynecologic Oncologists meeting in Orlando, Florida. (onclive.com)
Improved patient stratification1
- CrossTalk is an interdisciplinary study that utilises the state-of-the-art technologies in order to identify novel opportunities for targeted therapeutic intervention and improved patient stratification. (dcu.ie)
Regimen1
- Another 14 patients received the same regimen plus amifostine 500 mg given prior to carboplatin as a short infusion over approximately 10 minutes. (cancernetwork.com)
Healthy tissues1
- On the one hand, conformal techniques offer a substantial decrease in the dose deposited in the surrounding healthy tissues, and therefore reduce the risk of serious late complications. (viamedica.pl)
Standard2
- For example, Papiez and Timmerman [10] discussed dose shaping and dose delivery techniques using standard beam arrangements with coplanar and noncoplanar beams. (scirp.org)
- Indeed the initial standard fractionation of 1.8-2 Grays needed 5 sessions per week during 6-7 weeks. (prostatherapy.com)
Treatments1
- This is particularly consequential for human papillomavirus (HPV) negative patients with literature demonstrating higher likelihood of missed treatments compared to their HPV positive counterparts, which compounds with baseline inferior disease-related outcomes [ 10 ]. (biomedcentral.com)
Boost1
- When only the boost plans were compared, the results were 11.8% lower at the D1 dose and 12.01% higher at the D99 dose with the SP. (onkder.org)
Cancer15
- And HPV-associated oropharyngeal cancer "is a cancer of relatively younger patients," said Nishant Agrawal, MD , Professor and Director of Head and Neck Surgical Oncology, University of Chicago, at the 2016 Multidisciplinary Head & Neck Symposium sponsored by the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago. (ascopost.com)
- These patients have a long life expectancy-you can expect them to live 30 to 50 years or even longer as life expectancy continues to increase-vs head and neck cancer patients with disease related to smoking, who are diagnosed in their 60s and have maybe another 10 to 20 years to live because of other smoking-related cancers and medical comorbidities. (ascopost.com)
- The study concludes that in the 12 months following the pandemic, mortality could increase by 20% to 30% in patients with cancer. (ilcn.org)
- Higher local relapse rates were described for grade 3 tumours, triple negative breast cancer as well as for patients treated after primary systemic therapy for locally advanced tumours. (unav.edu)
- With a novel orthotopic mouse model, progress has been made in identifying a breast cancer stem or initiating population from TN breast cancer patients. (hdac-inhibitors.com)
- Patients who are radioresistant respond poorly to RT and may experience cancer progression. (nature.com)
- A meta-analysis of 7 studies and 1,114 patients compared surgical with nonsurgical management of esophageal cancer. (appliedradiationoncology.com)
- Title:-Effect of Natural Honey on Radiation Induced Oral Mucositis in Head and Neck Cancer Patients. (gov.bd)
- Title:- Prevention of Radiation Pneumonitis By Inheled Corticosteroid in Patients with Breast Cancer. (gov.bd)
- Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
- Human papillomavirus in clinically and histologically normal tissue of patients with genital cancer. (cancer.gov)
- One of the major challenge of cervical cancer care is Ethiopia is delay in diagnosis, since most of the patients seek medical care at advanced stage of the disease [ 7 , 9 ]. (biomedcentral.com)
- In order to answer this question, 133 studies were published, including 21,058 patients who were selected for the present survey with H&N cancer treated within the period of 1970-2010. (viamedica.pl)
- Soluble PD-L1 as a diagnostic and prognostic biomarker in resectable gastric cancer patients. (harvard.edu)
- Findings We estimated that breast cancer diagnosis in Rwanda costs 138.29 United States dollars (US$) per patient when conducting biomarker analysis by immunohistochemistry. (bvsalud.org)
Carboplatin1
- Cumulative carboplatin dose was 700 mg/m². (cancernetwork.com)
Stratification1
- However, one has always to keep in mind that many challenges do still exist such as what is the best sequence and timing of joint applications, what are the best immunotherapy approaches, how to overcome tumor resistances, what about healthy tissue cytotoxicity, or which biomarkers or matrices of biomarkers are most beneficial for patients stratification, just to mention the most burning ones. (frontiersin.org)
Adverse events3
- Adverse events include dermatitis, mucositis, xerostomia, and dysphagia and can be "life-altering" for patients. (ascopost.com)
- Emerging evidence suggests that RT dose alone cannot fully account for the variable severity of RT-related adverse events (rtAEs) observed in HNSCC patients. (biomedcentral.com)
- As surgical interventions have significant impact on morbidity and quality of life it is important to study the influence of different fractionation regimes on adverse events in the postoperative setting [ 5 ]. (biomedcentral.com)