• Five cases were reported but the phenotype resembles Dunnigan-type familial partial lipodystrophy rather than classic APL. (medscape.com)
  • Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy. (medscape.com)
  • A rare genetic disorder, familial partial lipodystrophy causes a drop in an important hormone called leptin that helps to regulate energy balance by inhibiting hunger. (massbio.org)
  • Stratton began to get involved with advocacy groups to learn more about familial partial lipodystrophy. (massbio.org)
  • Many people with Familial Partial Lipodystrophy do not know that they have it until later in life when it starts to severely affect their health. (wehealth.io)
  • The main subtypes of familial lipodystrophies are congenital generalized lipodystrophy, an autosomal recessive disorder characterized by near complete lack of metabolically active adipose tissue from birth, and familial partial lipodystrophy, Dunnigan type, an autosomal dominant disorder characterized by loss of subcutaneous fat from the extremities at puberty and excess fat accumulation in the face and neck. (medscape.com)
  • Lipodystrophy refers to the loss of adipose tissue. (medscape.com)
  • Human lipodystrophies: genetic and acquired diseases of adipose tissue. (medscape.com)
  • Lipodystrophies: windows on adipose biology and metabolism. (medscape.com)
  • Adachi M, Asakura Y, Muroya K, Goto H, Kigasawa H. Abnormal adipose tissue distribution with unfavorable metabolic profile in five children following hematopoietic stem cell transplantation: a new etiology for acquired partial lipodystrophy. (medscape.com)
  • Primary aims were to compare adipose tissue distribution in adult patients with juvenile-onset DM (JDM), with matched controls. (nih.gov)
  • Secondary aims were to explore how adipose tissue distribution is associated with cardio-metabolic status (cardiac dysfunction and metabolic syndrome) in patients. (nih.gov)
  • Generalized lipodystrophy is a rare disorder characterized by marked loss of adipose tissue with reduced triglyceride storage capacity, leading to a severe form of metabolic syndrome including hypertriglyceridemia, insulin resistance, type 2 diabetes mellitus, and hepatic steatosis. (elsevierpure.com)
  • The presence of pericardial fat was also found, representing a previously undescribed adipose depot in generalized lipodystrophy. (elsevierpure.com)
  • Lipodystrophy encompasses a heterogeneous group of disorders associated with whole body or partial lack of adipose tissue, which can be inherited (genetic-origin) or acquired. (scienceblogs.com)
  • Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
  • In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. (cambridge.org)
  • In a preliminary study that involved 54 patients, treatment with tesamorelin (Egrifta) reduced visceral adipose tissue 34 cm 2 compared with a reduction of 8 cm 2 achieved by patients on placebo ( P =0.005), reported Steven Grinspoon, MD, of Harvard Medical School and Massachusetts General Hospital in Boston, and colleagues, at the International AIDS Conference . (medpagetoday.com)
  • Lipodystrophy is a disorder featuring loss of normal adipose tissue depots due to impaired production of normal adipocytes. (bvsalud.org)
  • Lipodystrophy syndromes are characterized by a progressive metabolic impairment secondary to adipose tissue dysfunction and may have a genetic background. (bvsalud.org)
  • Acquired partial lipodystrophy (APL) also known as Barraquer-Simons syndrome or cephalothoracic lipodystrophy, is one of the rare forms of lipodystrophy. (medscape.com)
  • [ 4 ] This may be related to the fact that in this syndrome, patients have limited fat loss. (medscape.com)
  • Berardinelli-Seip syndrome and Seip-Lawrence syndrome are congenital and acquired forms, respectively, of total lipodystrophy, and both are associated with diabetes mellitus and hyperlipidemia. (logicalimages.com)
  • Caramaschi P, Biasi D, Lestani M, Chilosi M. A case of acquired partial lipodystrophy associated with POEMS syndrome. (medscape.com)
  • Metabolic syndrome was found in 25.7% of the patients and none of the controls. (nih.gov)
  • In patients, VAT levels were correlated with age, disease duration and occurrence of metabolic syndrome and cardiac dysfunction. (nih.gov)
  • Increasing the body's production of growth hormone may be an effective treatment for HIV lipodystrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • Use of an oral antidiabetes medication produced significant improvement in a group of patients with HIV lipodsytrophy, a syndrome involving the redistribution of fat and other metabolic changes in those receiving combination drug therapy for HIV infection. (news-medical.net)
  • Partial lipodystrophy it is commonly misdiagnosed as Cushing's or mistaken as problems associated with polycystic ovarian syndrome or metabolic syndrome while the rest of the health problems are ignored. (massbio.org)
  • Progression of lipodystrophy syndrome is a big challenge in HIV treatment. (researchgate.net)
  • However, long-term use of ART leads to a fat redistribution syndrome, with peripheral fat loss and central adiposity, and metabolic abnorm- alities called, generally, lipodystrophy. (researchgate.net)
  • A team led by researchers from Massachusetts General Hospital (MGH) and McGill University Health Centre found that treatment with tesamorelin, a growth-hormone-releasing factor, significantly reduced deep abdominal fat deposits and improved the metabolic aspects of HIV lipodystrophy in a group of patients with the syndrome. (harvard.edu)
  • The metabolic aspects of the syndrome - changes in cholesterol and other blood lipids, and development of insulin resistance - could increase the risk of cardiovascular disease in HIV-infected patients. (harvard.edu)
  • Mibavademab is under clinical development by Regeneron Pharmaceuticals and currently in Phase II for Acquired Generalized Lipodystrophy (Lawrence Syndrome). (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Acquired Generalized Lipodystrophy (Lawrence Syndrome) does not have sufficient historical data to build an indication benchmark PTSR for Phase II. (pharmaceutical-technology.com)
  • It is a rare syndrome with no known prevalence, although it is more common than the generalized form of acquired lipodystrophy (Lawrence syndrome). (medscape.com)
  • One subtype of laminopathy is the generalized lipodystrophy-associated progeroid syndrome (GLPS), which occurs in patients with heterozygous mutations of the LMNA gene c.29C>T(p.T10I). (bvsalud.org)
  • A morphological, anatomical, metabolic change in body fat and bone metabolism is the set of changes known as lipodystrophy syndrome 1-8 . (bvsalud.org)
  • Owing to its rarity in male patients, we are presenting the case of acquired partial lipodystrophy in a 12-year-old boy with a granular accumulation of C 3 in the basement membrane on skin biopsy. (medscape.com)
  • The Michigan Medicine Division of Metabolism, Endocrinology and Diabetes, and the Brehm Center for Diabetes Research collectively host a major referral center for the study of lipodystrophy syndromes. (newswise.com)
  • [ 5 ] mental retardation and retinal disease are among the syndromes that also are associated with acquired partial lipodystrophy. (medscape.com)
  • Published April 24, 2018 at 750 × 525 in Lipodystrophy Syndromes: Presentation and Treatment . (endotext.org)
  • The lipodystrophy syndromes are a heterogeneous group of syndromes characterized by selective loss of fat from various parts of the body. (medscape.com)
  • In an open-label study, funded by the National Institutes of Health, the research team predicted the response of 23 patients with partial lipodystrophy-associated nonalcoholic steatohepatitis (fatty liver) to metreleptin, a man-made version of the naturally occurring hormone leptin, which regulates fat and glucose metabolism. (newswise.com)
  • Kurugöl Z, Ulger Z, Berk O, Tugral O. Acquired partial lipodystrophy associated with varicella. (medscape.com)
  • Cite this: Acquired Partial Lipodystrophy Associated With Hypocomplementemia - Medscape - Sep 01, 2005. (medscape.com)
  • Fatty liver, or excess fat building up in the liver, is a common metabolic disturbance seen in patients with lipodystrophy," says Elif Oral, M.D., associate professor of endocrinology at Michigan Medicine and principal investigator of the study. (newswise.com)
  • To determine whether the metabolic and morphological abnormalities seen in patients with lipodystrophy (LD) are reversed by stopping protease inhibitors (PIs). (natap.org)
  • Educating patients about the disease and its associated complications is very important. (medscape.com)
  • Drug-induced lipodystrophy in patients with HIV on ART is associated with metabolic complications, an increased risk of cardiovascular disease, and pancreatitis. (logicalimages.com)
  • Context: Leptin replacement therapy improves metabolic complications in patients with lipodystrophy and severe hypoleptinemia (SH), but whether the response is related to the degree of hypoleptinemia remains unclear. (elsevierpure.com)
  • Researchers at UT Southwestern Medical Center have uncovered crucial clues about a paradoxical disease in which patients with no body fat develop many of the health complications usually found in obese people. (news-medical.net)
  • More than a decade of work conducted by UT Southwestern Medical Center at Dallas researchers has led to a better understanding of the underlying causes of lipodystrophies - disorders characterized by the selective loss of fat tissues, resulting in metabolic complications, such as severe diabetes and high blood cholesterol levels. (news-medical.net)
  • Not only are patients with lipodystrophy at increased metabolic risk, but the severity of metabolic complications observed is closely related to the extent of their fat loss. (scienceblogs.com)
  • The purpose of this study was to investigate the effect of the treatment of buttock lipoatrophy with PMMA-microspheres, its possible complications and the patient satisfaction with this therapy. (researchgate.net)
  • The few complications that our patients experienced appeared between days 2 and 15. (liposuction.com)
  • Metreleptin used for treatment of complications of leptin deficiency in patients with generalised lipodystrophy is classified in A16AA. (whocc.no)
  • Lipodystrophy United provides many resources about symptoms, diagnosis, and treatment for people with all forms of lipodystrophy. (wehealth.io)
  • Patients affected by the diseases generally have severe insulin resistance, high lipids in their blood and fatty liver. (newswise.com)
  • Patients were also tested for insulin resistance, glucose intolerance, hyperlipidaemia, TNF- and TNF receptor levels before and after stopping PIs. (natap.org)
  • A new study finds that adipocyte SLC7A10 impairments may impact lipid accumulation during insulin resistance in patients with obesity. (medscape.com)
  • Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
  • Compared with other types of lipodystrophy, acquired partial lipodystrophy is seldom associated with insulin resistance and its related metabolic derangements. (medscape.com)
  • Insulin resistance (IR) is common in HIV-seropositive patients, particularly among those receiving protease inhibitor (PI) and is more prevalent among those with lipoatrophy or fat accumulation in the visceral region. (bvsalud.org)
  • Tesamorelin is the only FDA drug approved for the intended reduction of abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection. (medpagetoday.com)
  • A significant number of HIV-infected individuals who receive antiviral therapy develop lipodystrophy. (harvard.edu)
  • In the pediatric clinical trial, pediatric patients with type 1 diabetes had a higher incidence of severe symptomatic hypoglycemia compared to the adults in trials with type 1 diabetes. (rxlist.com)
  • Tablets is contraindicated in patients with moderate to severe hepatic impairment (see sections 4.3, 4.4, and 5.2). (who.int)
  • The patients selected were not obese, but had moderate to severe lipodystrophy. (liposuction.com)
  • The toxicity of AZT is so well documented that the pharmaceutical company that makes and commercializes it typically writes, "Retrovir (Zidovudine) may be associated with severe hematologic toxicity including granulocytopenia and severe anemia particularly in patients with advanced HIV disease" and they add that, "Myopathy and myositis with pathologic changes similar to that produced by HIV disease, have been associated with prolonged use of Retrovir" (5). (robertogiraldo.com)
  • Severe malabsorption may be present in patients diagnosed late in the clinical course. (msdmanuals.com)
  • A 16-year-old male patient was treated for diabetic ketoacidosis, presenting with premature aging appearance, systemic lipodystrophy, severe fatty liver, and decreased bone density. (bvsalud.org)
  • The Division houses a clinical program to deliver state-of-the-art care for atypical forms of diabetes that aims to improve the lives of patients afflicted with these unusual diseases. (newswise.com)
  • Misra A, Peethambaram A, Garg A. Clinical features and metabolic and autoimmune derangements in acquired partial lipodystrophy: report of 35 cases and review of the literature. (medscape.com)
  • Over 100 free commonly used clinical formulas and calculator tools to help diagnose, treat, prevent, and determine prognosis of patients at point of care. (guidelinecentral.com)
  • Identify clinical preventive services that are appropriate for your patients. (guidelinecentral.com)
  • The opposite clinical example of lipodystrophy is multiple symmetric limpomatosis. (scienceblogs.com)
  • A randomized clinical trial of intravenous methylprednisolone with two protocols in patients with Graves' Orbitopathy. (medscape.com)
  • It advocates and acts as a catalyst for new patient diagnosis by assisting healthcare professionals in the understanding of lipodystrophy trends, physical attributes and clinical symptoms in order to aid in the advancement of knowledge, treatment and future research. (massbio.org)
  • NORD shares information about opportunities to participate in clinical trials and other studies so that patients and their physicians may decide whether specific studies are appropriate for them. (rarediseases.org)
  • NORD offers financial support for study-related expenses and concierge travel arrangements to patients participating in Catalyst Approved MuSK-002 Clinical Study with Amifampridine Phosphate through its RareCare Program. (rarediseases.org)
  • Celgene is conducting a clinical trial of fedratinib in patients with DIPSS (dynamic international prognostic scoring system)-intermediate or high- risk primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF), or post-essential thrombocythemia myelofibrosis (post-ET MF) and previously treated with Ruxolitinib to evaluate the percentage of patients with at least a 35% reduction of spleen volume and to evaluate the safety of fedratinib. (rarediseases.org)
  • This paper reports the first case of GLPS in China and compares the clinical features of other GLPS patients with literature reports. (bvsalud.org)
  • these findings with the patients' clinical and laboratory parameters. (who.int)
  • The liver disease at baseline is quite significant among the patients in this study, which showed a significant degree of inflammation and fibrosis, even in the absence of liver test abnormalities," says Nevin Ajluni, M.D., assistant professor of endocrinology at Michigan Medicine and the presenting author of the study. (newswise.com)
  • Acquired partial lipodystrophy is associated with increased risk for developing metabolic abnormalities. (medscape.com)
  • The complement abnormalities of lipodystrophy. (medscape.com)
  • Complement abnormalities in acquired lipodystrophy revisited. (medscape.com)
  • This appears to be the most promising strategy to date for a safe, effective method of reducing excess visceral fat deposits and improving lipid abnormalities in HIV-infected patients, thereby improving their risk for cardiovascular disease," says Steven Grinspoon of the MGH Neuroendocrine Unit and Program in Nutritional Metabolism, the report's senior and corresponding author. (harvard.edu)
  • In contrast with their occurrence in other types of lipodystrophy, diabetes and impaired glucose tolerance are found only rarely in APL, being reported in 6.7% and 8.9% of patients, respectively. (medscape.com)
  • Occurrence of lipodystrophy (P = 0.02) and male sex (P = 0.04) tended to be independently associated with cardiac dysfunction. (nih.gov)
  • The occurrence of diabetes is four times greater in HIVseropositive patients than in HIV-seronegative patients matched by age and body mass 10,13-16 . (bvsalud.org)
  • GHRH analogs such as tesamorelin can be used to treat HIV-associated lipodystrophy. (wikipedia.org)
  • The U.S. Food and Drug Administration today approved Egrifta (tesamorelin) to treat HIV patients with lipodystrophy, a condition in which excess fat develops in different areas of the body, most notably around the liver, stomach, and other abdominal organs. (medicineandtechnology.com)
  • They found the median change in lipid to water percentage -- a marker of liver fat -- was reduced by 2% in the patients on tesamorelin compared with a 0.9% increase among the placebo patients ( P =0.003). (medpagetoday.com)
  • A 3-month follow up was attended by 20 placebo patients and 25 patients who had been assigned tesamorelin. (medpagetoday.com)
  • A 6-month visit was attended by 20 patients on placebo and 23 on tesamorelin. (medpagetoday.com)
  • He reported that liver enzyme tests for liver inflammation markers were lower among patients on tesamorelin. (medpagetoday.com)
  • Study participants - HIV lipodystrophy patients recruited from 43 sites around the United States and Canada - were randomly assigned to receive either tesamorelin or a placebo, self-administered daily for six months. (harvard.edu)
  • Tesamorelin used in the treatment of HIV patients with lipodystrophy is classified in this group. (whocc.no)
  • Patients with generalized lipodystrophy, compared with controls, also had a striking degree of concentric LV hypertrophy, independent of blood pressure: LV mass index 101.0 ± 18.3 versus 69.0 ± 17.7 g/m 2 , respectively (p = 0.02), and LV concentricity 1.3 ± 0.3 versus 0.99 ± 0.1 g/ml, respectively (p = 0.04). (elsevierpure.com)
  • In conclusion, these findings advance the lipotoxicity hypothesis as a putative underlying mechanism for the dramatic concentric LV hypertrophy found in generalized lipodystrophy. (elsevierpure.com)
  • Although abdominal hypertrophy may be less common with newer antiretroviral therapy, there exists a substantial group of patients with abdominal fat accumulation in the context of long-term prior antiretroviral therapy," the researchers noted. (medpagetoday.com)
  • On the other hand, there is evidence that HIV-1 infection on its own contributes to the development of the lipodystrophic phenotype by interfering with some key genes of adipocyte differentiation and mitochondrial function on patients which have not received antiretroviral treatment. (wikipedia.org)
  • Lipodystrophy, or fat redistribution, is frequently seen in patients on long-term antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection. (logicalimages.com)
  • Low-dose growth hormone treatment reduced abdominal fat deposits and improved blood pressure and triglyceride levels in a group of patients with HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (news-medical.net)
  • Tesamorelin's ability to reduce liver fat in conjunction with the reduction of abdominal fat may be clinically important for patients with HIV infection who have fatty liver disease along with increased abdominal fat," Grinspoon said. (medpagetoday.com)
  • Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. (who.int)
  • Health-care providers and their patients may opt to consider using antiretroviral drugs after nonoccupational HIV exposures that carry a high risk for infection, but only after careful consideration of the potential risks and benefits and with a full awareness of the gaps in current knowledge. (cdc.gov)
  • Health-care providers may want to provide their patients with a system for promptly initiating evaluation, counseling, and follow-up services after a reported sexual, injecting-drug-use, or other nonoccupational HIV exposure that might put a patient at high risk for acquiring infection. (cdc.gov)
  • Injecting-drug-use exposure through shared injection equipment can put a patient at risk for acquiring other viral infections (e.g., hepatitis B and hepatitis C). All persons evaluated for possible nonoccupational HIV exposure should be counseled to initiate, resume, or improve risk-reduction behaviors to avoid future exposure and to prevent possible secondary transmission until their current HIV infection status is determined. (cdc.gov)
  • This patient reported that she was riding a bicycle and had a scratch over the left ankle, producing an infection with edema, erythema, and pain. (liposuction.com)
  • Treatment with an investigational drug that induces the release of growth hormone significantly improved the symptoms of HIV lipodystrophy, a condition involving redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. (harvard.edu)
  • Affected patients may have subtle defects of cell-mediated immunity that predispose to infection with T. whipplei . (msdmanuals.com)
  • SARS-COV-2 infection outcomes in patients with congenital generalized lipodystrophy. (cdc.gov)
  • Lipodystrophy, an abnormal abdominal fat accumulation, develops in 20% to 30% of patients receiving antiretroviral drugs. (medpagetoday.com)
  • Our population was primarily male and had been living with HIV and receiving antiretroviral therapy for a long period, consistent with many patients exhibiting lipodystrophic changes in fat," Grinspoon added. (medpagetoday.com)
  • This report reviews the topics raised at the meeting, provides background information on patient management options, and presents considerations for antiretroviral therapy. (cdc.gov)
  • To assess the prevalence of oral manifestations in HIV/AIDS patients and a possible correlation of the development of diabetes mellitus due to highly active antiretroviral therapy (HAART). (bvsalud.org)
  • Utility of polygenic scores for differentiating diabetes diagnosis among patients with atypical phenotypes of diabetes. (medscape.com)
  • If patients have a Flatbush phenotype, negative autoimmune testing may help confirm the diagnosis. (ccjm.org)
  • The diagnosis of Whipple disease may be missed in patients without prominent gastrointestinal symptoms. (msdmanuals.com)
  • The diagnosis of lipodystrophy can be challenging, often requiring a multidisciplinary approach, given the pleiotropic effect, involving several tissues. (bvsalud.org)
  • Investigators observed their NASH score, a numerical score for progression of fatty liver disease in patients, and their NAS score, a numerical score for progression of non-alcoholic fatty liver disease. (newswise.com)
  • Nonalcoholic Fatty Liver Disease, Liver Fibrosis and Utility of Noninvasive Scores in Patients with Acromegaly. (medscape.com)
  • While some patients with nonalcoholic fatty liver disease have a benign course, others may develop a more serious condition involving liver inflammation, cellular damage, and fibrosis, which can progress to cirrhosis and end-stage liver disease or to liver cancer," he added. (medpagetoday.com)
  • About 30% to 40% of people living with HIV develop nonalcoholic fatty liver disease, but not necessarily in conjunction with lipodystrophy. (medpagetoday.com)
  • Individuals who suffer from a condition called lipodystrophy, have little to no fat tissue (they look extremely athletic, with defined musculature) but display many of the metabolic symptoms thought to be exclusive to obese individuals. (scienceblogs.com)
  • Roux-en-Y gastric bypass surgery progressively alters radiologic measures of hypothalamic inflammation in obese patients. (mpg.de)
  • The General Endocrine Clinic at Tufts Medical Center in Boston provides evaluation and treatment for patients with a wide range of endocrine disorders. (tuftsmedicalcenter.org)
  • The abdomen may be protuberant in these disorders due to enlargement of the liver and spleen, but unlike HIV-associated lipodystrophy, areas of fat accumulation are not seen. (logicalimages.com)
  • Bristol-Myers Squibb and AstraZeneca announced the results from a 12-month sub-group analysis of a National Institutes of Health (NIH), open-label, long-term research study of metreleptin, an investigational human hormone leptin analogue for the treatment of metabolic disorders associated with inherited or acquired lipodystrophy (LD). (empr.com)
  • The partial lipodystrophy study participants underwent two liver biopsies, one at the beginning of the trial and after one year of treatment. (newswise.com)
  • Atazanavir (as sulfate)/Ritonavir 300 mg/100 mg Tablets must not be administered to patients with decompensated liver disease (see sections 4.2 and 4.4). (who.int)
  • It was conducted to examine the effects of metreleptin on metabolic parameters associated with LD, including HbA1c, triglyceride levels and liver function tests, in pediatric patients enrolled in the NIH study. (empr.com)
  • MELBOURNE, Australia -- HIV-infected patients treated with a growth hormone releasing hormone analog achieved modest reductions in abdominal and liver fat, researchers said. (medpagetoday.com)
  • Therefore, activating NRF2 signaling or direct elevation of NQO1 in the liver provides new possibilities to partially reduce steatosis that accompanies lipodystrophy. (bvsalud.org)
  • But this study shows clearly that the novel strategy of inducing the release of endogenous growth hormone can improve symptoms of lipodystrophy, relieving patient distress - which may improve their compliance with therapy - and reducing several cardiovascular risk factors. (harvard.edu)
  • Lipodystrophy is a group of rare diseases that share in common the selective loss of fat tissue from the body. (newswise.com)
  • In addition, some patients saw reductions in glucose control and lipid levels, but the differences noted in the entire cohort did not attain statistical significance. (newswise.com)
  • Insulin levels in LD patients (17.9 mU/l) on PIs were significantly (P =0.02) higher than in controls (6.6 mU/l), and did not alter (21.2 mU/l) when Pis were stopped, despite equivalent glucose tolerance. (natap.org)
  • Although these patients need insulin at the outset, treatment can often be changed to oral glucose-lowering agents. (ccjm.org)
  • 12 In the 1930s, Himsworth 13 infused both glucose and insulin into diabetes patients and ob served 2 distinct glucose responses: either glucose levels declined, suggesting the patient was sensitive to insulin but did not make enough of it, or glucose increased, suggesting the patient was making insulin but was resistant to it. (ccjm.org)
  • A study by Gusenoff et al found a high rate of minor wound-healing problems in patients who, following massive weight loss, underwent medial thigh plasty. (medscape.com)
  • Patients who underwent ankle or leg augmentation experienced a 0.5 cm loss in diameter over the treated areas after the 1.5-month postoperative period. (liposuction.com)
  • Introduction: Femoral head avascular necrosis is a dangerous complication that can occur during glucocorticoid therapy, its frequency having been counted up to 40% of patients using corticoids. (endocrine-abstracts.org)
  • Gao J, Li Y, Fu X, Luo X. A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene. (medscape.com)
  • And then I got one that had this subject heading: "Olympic medalist and muscular dystrophy patient with the same mutation. (propublica.org)
  • She was the muscular dystrophy patient, and she had an elaborate theory linking the gene mutation that made her muscles wither to an Olympic sprinter named Priscilla Lopes-Schliep. (propublica.org)
  • I'm lucky that I'm one of the healthier ones with lipodystrophy," said Stratton, who has the most common mutation. (massbio.org)
  • Conclusion: Metreleptin replacement therapy is equally effective in FPLD patients with both SH and MH in reducing serum and hepatic triglyceride levels, but did not improve hyperglycemia. (elsevierpure.com)
  • To test this hypothesis, the first cardiac magnetic resonance study of patients with generalized lipodystrophy was performed, using magnetic resonance imaging and localized proton spectroscopy to detect excessive triglyceride content in the hypertrophied myocytes. (elsevierpure.com)
  • As hypothesized, myocardial triglyceride content was threefold higher in patients than controls: 0.6 ± 0.2% versus 0.2 ± 0.1% (p = 0.004). (elsevierpure.com)
  • Adverse reactions associated with LEVEMIR include hypoglycemia, allergic reactions, injection site reactions, lipodystrophy, rash and pruritus ( 6 ). (nih.gov)
  • Sequencing of the reannotated LMNB2 gene reveals novel mutations in patients with acquired partial lipodystrophy. (medscape.com)
  • Recently novel mutations in the LMNB2 gene have been identified in 4 of 5 acquired partial lipodystrophy patients tested. (medscape.com)
  • Congenital generalized lipodystrophy type 4 (CGL4) is an extremely rare subtype, caused by mutations in the polymerase I and transcript release factor (PTRF) gene. (bvsalud.org)
  • The toxicity of AZT, the drug now prescribed indefinitely to both healthy "HIV-positive" individuals and to AIDS patients, has been solidly documented (1,8-13). (robertogiraldo.com)
  • Partial lipodystrophy results in fat loss typically in the arms, legs, head and torso, and fat accumulation in the neck, face and intra-abdominal areas of the body. (newswise.com)
  • The researchers reported patients with a lower baseline leptin level had a higher response rate after one year of treatment with metreleptin, a pharmaceutical produced by Novelion Therapeutics' subsidiary. (newswise.com)
  • Of the 18 patients who completed treatment after one year, NASH scores improved from a mean of 6 at baseline (showing moderate to advanced disease) to a mean of 5. (newswise.com)
  • Patients that experienced the two-point or greater reduction improvement in their scores from treatment had a lower baseline leptin level of 14.5 ng/mL versus non-responders whose average leptin level at baseline was 25 ng/mL. (newswise.com)
  • The choice of fixed dose combination Atazanavir (as sulfate)/Ritonavir 300 mg/100 mg Tablets for use in treatment-experienced patients should be based on treatment history of patients and, if available, also on individual viral resistance testing (see sections 4.4 and 5.1). (who.int)
  • Treatment options were autologous fat transplant or hard silicone implants, but not all patients have enough fat donor area and silicone implants have to be placed highly, at the area of the gluteus maximus, not helping the patients in their sitting problem. (researchgate.net)
  • Patients were photographed before and after treatment. (researchgate.net)
  • however, there was a significant decrease (P =0.02) in the LD patients on stopping PIs (Table). (natap.org)
  • Newswise - ANN ARBOR, Mich. - Researchers at Michigan Medicine have found the livers of patients with a rare disease that affects metabolism have responded positively to leptin therapy. (newswise.com)
  • Semglee ( insulin glargine injection) is a long-acting human insulin analog indicated to improve glycemic control in adults and pediatric patients with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus. (rxlist.com)
  • The safety and effectiveness of Semglee to improve glycemic control in pediatric patients with type 1 diabetes mellitus have been established in pediatric patients. (rxlist.com)
  • The use of Semglee for this indication is based upon an adequate and well-controlled trial of another insulin glargine product in pediatric patients age 6 to 15 years with type 1 diabetes and additional data in adults with type 1 diabetes. (rxlist.com)
  • The safety and effectiveness of Semglee in pediatric patients younger than 6 years of age with type 1 diabetes and pediatric patients with type 2 diabetes have not been established. (rxlist.com)
  • Approach to the Patient with Youth-Onset Type 2 Diabetes. (medscape.com)
  • Glucagon-like peptide 1 Analogues as Adjunctive Therapy for Patients with Type 1 Diabetes: an Updated Systematic Review and Meta-analysis. (medscape.com)
  • Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study. (medscape.com)
  • An essay on the effects of dexamethasone and the potential risks of its inadvertent use in patients with diabetes. (cdc.gov)
  • 56 patients were examined, divided into two groups, Group 1, the HIV group, with 28 patients known to be HIV+, who developed diabetes mellitus due to HAART, and Group 2, the control group, with 28 patients with HIV- diagnosed with diabetes mellitus. (bvsalud.org)
  • The molecular basis of genetic lipodystrophies. (medscape.com)
  • Generalized lipodystrophy results in fat loss throughout the entire body. (newswise.com)
  • Circulating levels of these adipokines are lower in generalized versus partial lipodystrophy as predicted from the loss of fat. (medscape.com)
  • 497 HIV-associated lipodystrophy commonly presents with fat loss in face, buttocks, arms and legs. (wikipedia.org)
  • Nowadays, fat loss at the lower part of buttocks has become another problem as patients have started to complain that it is painful to be seated for a long time and/or on hard surfaces. (researchgate.net)
  • Fat loss on perianal area and lower part of the buttock severely affects patients' quality of life, as it becomes painful, and sometimes impos- sible, to be seated for a long time and/or on hard surfaces ( Figure 1). (researchgate.net)
  • A study by Bertheuil et al, however, indicated that medial thigh plasty can improve the quality of life in patients who have undergone a massive weight loss, although the report, on 21 individuals, did not find that the surgery improved the quality of subjects' sex lives. (medscape.com)
  • People with lipodystrophy experience an uncontrolled loss of fat tissue, especially fat under the skin. (wehealth.io)