Patients with leukemia leukemia myelomonocytic acute. Medical search. Frequent questions

Determine the effect of sargramostim (GM-CSF) on the progression-free 1-year survival of patients with myelodysplastic syndrome who have undergone T-cell-depleted CD34+ augmented allogeneic bone marrow transplantation. (knowcancer.com)
increased risk of myelodysplastic syndrome (MDS), acute myeloid leukaemia (AML) and T-cell acute lymphoblastic leukaemia (T-ALL). (eviq.org.au)
We identify a mutation (D262N) in the erythroid-affliated transcriptional repressor GFI1B, in an acute myeloid leukemia (AML) patient with antecedent myelodysplastic syndrome (MDS). (lu.se)
A fraction of these patients, in particular those displaying trisomy 8 or monosomy 7, are at risk of developing a myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). (lu.se)

The current study attempts to demonstrate the existence of double minute chromosomes via FLT3 gene amplification in a patient diagnosed with chronic myelomonocytic leukemia (CMML). (hindawi.com)
FLT3 amplification as dmins in a patient with CMML was revealed. (hindawi.com)
Here, to our best knowledge, we present the first case of amplification encompassing the FLT3 gene acting as dmin in a patient with chronic myelomonocytic leukemia (CMML). (hindawi.com)
Additional sex combs-like 1 ( ASXL1 ) mutations have been described in all forms of myeloid neoplasms including chronic myelomonocytic leukemia (CMML) and associated with inferior outcomes, yet the molecular pathogenesis of ASXL1 mutations ( ASXL1 -MT) remains poorly understood. (biomedcentral.com)
Transformation of CMML to secondary AML (sAML) is one of the leading causes of death in CMML patients. (biomedcentral.com)
Previously, we observed that transcription factor RUNX1 mutations ( RUNX1 -MT) coexisted with ASXL1 -MT in CMML and at myeloid blast phase of chronic myeloid leukemia. (biomedcentral.com)
A prognostic score including mutation profile and clinical features for patients with CMML undergoing stem cell transplantation. (cdc.gov)
NPM1 gene mutations are rarely detected in patients with non-acute MNs, such as myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML)," wrote the authors, led by Chen Wang, MD, of the Department of Internal Medicine in the Morsani College of Medicine at the University of South Florida in Tampa. (bloodcancerstoday.com)
Controls were patients with AML who had a history of MDS or CMML and NPM1 mutations detected (n=31). (bloodcancerstoday.com)
Background In myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML), achievement of morphologic complete response (CR) is a prerequisite for potential cure. (kl.ac.at)
Thrombocytopenia 2 years before, chronic myelomonocytic leukemia (CMML) 1 year before. (atlasgeneticsoncology.org)
PDGFRβ gene rearrangements are infrequent entities, which are mostly diagnosed in patients presenting with atypical CML, chronic myelomonocytic leukemia (CMML), myelodysplastic/myeloproliferative disorders (MDS/MPN) or juvenile myelomonocytic leukemia (JMML). (fortunejournals.com)

In 2005, Ogata and Yoshida documented that PTPN11 mutations can be identified in approximately 40% of Noonan syndrome patients and in greater than 80% of LEOPARD syndrome patients. (medscape.com)
CBF members are frequent targets of mutations and rearrangements in human leukemia. (wikipedia.org)
Point-mutations in RUNX1 gene have been reported in patients with familial platelet disorder, myeloid dysplastic syndrome, and chronic myelomonocytic leukemia. (wikipedia.org)
In addition, RUNX1 mutations have also been reported in Acute myeloid leukemia (AML). (wikipedia.org)
Treatment of AML varies based on the prognosis and mutations identified in the patient sample. (wikipedia.org)
The contribution of RUNX1 mutations in the pathogenesis of myeloid transformation in ASXL1 -mutated leukemia, however, remains unclear. (biomedcentral.com)
Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 mutations played a critical role in leukemia transformation. (biomedcentral.com)
Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been identified. (cancer-genetics.org)
Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients. (cdc.gov)
Looking for somatic mutations in UBA1 in patients with chronic myelomonocytic leukemia associated with systemic inflammation and autoimmune diseases. (cdc.gov)
The Prognostic Ability of RAS Pathway-Related Gene Mutations in Patients with Myeloid Neoplasms Treated with Hypomethylating Agents. (cdc.gov)
Mutations in chronic myelomonocytic leukemia and their prognostic relevance. (cdc.gov)
Among 676 MDS patients, 43 patients (6.4%) harbored BCOR mutations. (biomedcentral.com)
A higher frequency of BCOR mutations (8.7%) was investigated in patients with normal chromosome, compared to 4.2% in patients with abnormal karyotype ( p = 0.040). (biomedcentral.com)
BCOR mutations occur more frequently in CN MDS patients, predicting higher risk of leukemia transformation. (biomedcentral.com)
Multiple large cohort studies of adult MDS patients found recurrent mutations in genes important in epigenetic regulation (e.g. (nature.com)
We show that Ras/MAPK pathway mutations are common in pediatric primary MDS (45%) while mutations in RNA splicing genes are rare (2%), and that germline SAMD9/SAMD9L mutations are present in 17% of primary MDS patients. (nature.com)
Other notable findings were that concurrent baseline DNMT3A mutations tended to be associated with inferior outcomes, and patients who underwent transplantation had better outcomes. (bloodcancerstoday.com)
DDX41 mutations in patients with non-myeloid hematologic neoplasms. (viictr.org)
Using direct and parallel sequencing, we found no recurrent mutations in typically large deletion 7q and monosomy 7 patients. (elsevierpure.com)
Hodgkin's lymphoma in a patient with Noonan syndrome with germ-line PTPN11 mutations. (lu.se)
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia. (lu.se)
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia. (lu.se)
BRAFV600E mutations are identified in 50 to 60% of patients who have LCH. (msdmanuals.com)
About 10 to 15% of patients have MAP2K1 mutations. (msdmanuals.com)

Although the importance of the hematopoietic transcription factor PU.1 in acute myeloid leukemia (AML) has been demonstrated, the expression of PU.1 in acute promyelocytic leukemia (APL) patient samples awaits further investigation. (biomedcentral.com)
Acute promyelocytic leukemia (APL) is typified by the t(15;17) translocation, which generates the PML-RARα fusion protein and produces a beneficial response to all- trans retinoic acid (ATRA) and arsenic trioxide [ 1 ]. (biomedcentral.com)
The present paper reports the case of a patient whose promyelocytic leukemia was diagnosed after hemorrhage resulting from the simple extraction a tooth. (bvsalud.org)

Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia. (cdc.gov)
Juvenile myelomonocytic leukemia - A bona fide RASopathy syndrome. (cdc.gov)
This phase II trial studies how well trametinib works in treating patients with juvenile myelomonocytic leukemia that has come back (relapsed) or does not respond to treatment (refractory). (ucbraid.org)
For comparison, we similarly characterize 23 cases with overlapping features of MDS and myeloproliferative neoplasm (MDS/MPN), namely juvenile myelomonocytic leukemia (JMML), and 8 cases of AML with myelodysplasia-related changes (AML-MRC). (nature.com)
Given the strong association between monosomy 7 and mutation of genes involved in the RAS pathway in juvenile myelomonocytic leukemia, we also screened for pathogenetic variants in KRAS, NRAS, and PTPN11, but did not detect any changes. (lu.se)
Genome-wide single-nucleotide polymorphism analysis in juvenile myelomonocytic leukemia identifies uniparental disomy surrounding the NF1 locus in cases associated with neurofibromatosis but not in cases with mutant RAS or PTPN11. (lu.se)
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. (lu.se)

Despite major accomplishments in our understanding of the pathogenesis of lung fibrosis ( 1 ), the diagnosis and management of patients with IPF continues to pose significant challenges ( 2-4 ). (atsjournals.org)
This is an international consensus statement defining the diagnosis, evaluation, and management of patients with IPF that has been produced as a collaborative effort from the American Thoracic Society (ATS), European Respiratory Society (ERS), and the American College of Chest Physicians (ACCP). (atsjournals.org)
Even in these instances the diagnosis of IPF was frequently not well established and the series often included patients with other diseases or potential causes of lung fibrosis. (atsjournals.org)
In June 2017, a 76-year-old man received a diagnosis of acute myelomonocytic leukemia and was admitted to Poitiers University Hospital (Poitiers, France). (cdc.gov)
As with chronic myelogenous leukemia (CML) , the myeloproliferative aspect of SCLL has a chronic phase that transforms into a myeloblastic phase, typically within 1 year of diagnosis. (medscape.com)
T-cell acute lymphoblastic leukemia (T-ALL) is an uncommon, aggressive malignancy that rarely presents in the skin and is generally not considered as part of the differential diagnosis by dermatologists and dermatopathologists. (karger.com)
Leukemic cell infiltration of the skin (i.e., leukemia cutis) typically occurs after the diagnosis of leukemia and may precede the appearance of leukemic blasts in the peripheral blood [ 2 ]. (karger.com)
11 The purpose of this review is to present and evaluate the medical literature on the early ophthalmological manifestations of acute myeloid leukemia, which physicians should be aware of for an earlier and more efficient diagnosis and treatment. (dovepress.com)
See "Clinical manifestations and diagnosis of chronic myeloid leukemia" . (medilib.ir)
Bone marrow specimens were obtained after receiving informed consent from patients at the time of their diagnosis with de novo APL (Table 1 ). (biomedcentral.com)
The correct diagnosis and treatment of these patients depend on the knowledge of normal hemostasis mechanisms and the results of laboratory tests that evaluate these mechanisms. (bvsalud.org)
The diagnosis of leukemia is established, through a myelogram, by the presence of more than 25% of leukemic cells on a bone marrow aspirative on puncture 6 . (bvsalud.org)

r The risk of malignant transformation may be higher in patients with dominant negative variants compared to haploinsufficient variants. (eviq.org.au)
As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
According to French-American-British classification criteria, 13 patients had refractory anemia, 18 had refractory anemia with ringed sideroblasts, 9 had refractory anemia with excess of blasts, 4 had refractory anemia with excess of blasts in transformation to acute leukemia, and 5 had chronic myelomonocytic leukemia. (elsevierpure.com)
Eleven out of 12 patients with refractory anemia (RA) (91.6%), and all 3 patients with refractory anemia with excess blasts in transformation (RAEBt) (100%), were positive for survivin expression with the majority of cases showing abundant levels of the survivin transcript. (spandidos-publications.com)

Compared to the BCOR WT patients, the BCOR MUT patients showed a higher ratio of refractory anemia with excess blasts subset ( p = 0.008). (biomedcentral.com)
The level and frequency of survivin expression in patients with refractory anemia were compared to those in patients with AML. (spandidos-publications.com)

Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)
Acute myeloid leukemia (AML) is a heterogeneous clonal stem cell malignancy. (fortunejournals.com)
Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and myelodysplastic syndromes, pointing toward the essential role of this region in disease phenotype and clonal evolution. (elsevierpure.com)
Despite the recent success of tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML), approximately 2-17% of patients develop clonal cytogenetic changes in the Philadelphia-negative (Ph(-)) cell population. (lu.se)
Clonal duplication of a germline PTPN11 mutation due to acquired uniparental disomy in acute lymphoblastic leukemia blasts from a patient with Noonan syndrome. (lu.se)

and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
Leukemia & lymphoma 2021 9 63 (1): 250-252. (cdc.gov)
The Pediatric Leukemia & Lymphoma Program at UCLA is dedicated to the comprehensive care of children, adolescents and young adults with newly diagnosed and relapsed leukemias and lymphomas. (uclahealth.org)
As part of the NCI-designated UCLA Jonsson Comprehensive Cancer Center , the Pediatric Leukemia/Lymphoma research program is committed to the discovery of novel therapies for leukemia and uncovering some of the origins in the development of normal blood cells and leukemia. (uclahealth.org)

[ 12 ] In one Bosnian family, five patients had the same recurrent mutation Y279C in the PTPN11 gene, but had different phenotypes and a variable expression of multiple lentigines. (medscape.com)
A novel PTPN11 missense mutation in a patient with LEOPARD syndrome. (lu.se)
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. (lu.se)

PI3K inhibitors in chronic lymphocytic leukemia: where do we go from here? (haematologica.org)
One symptom specific to a subset of acute lymphocytic leukemia is an enlarged thymus, an organ between the breastbone and the windpipe. (gallivanlawfirm.com)
Acute lymphocytic leukemia (ALL) , which is the most common type of cancer in children. (medlineplus.gov)
Chronic lymphocytic leukemia (CLL) , which is one of the most common types of leukemia in adults. (medlineplus.gov)

PURINETHOL is not effective in chronic lymphatic leukemia, the lymphomas (including Hodgkins Disease), or solid tumors. (druglib.com)
Although childhood cancers are rare, leukemia and lymphomas comprise about 40% of the pediatric cancers. (uclahealth.org)
As long-time members of the Children's Oncology Group , a national group of pediatric cancer specialists, we have actively participated in the conduct of important national clinical trials resulting in the improved overall survival of patients with leukemias and lymphomas. (uclahealth.org)
These pediatric trials have also resulted in better overall survival for adolescents and young adults with leukemias and lymphomas compared to patients treated on adult trials. (uclahealth.org)
We strive to provide access for our patients participation onto the newest and most advanced clinical trials for the treatment of leukemias and lymphomas. (uclahealth.org)

Clinical, Hematologic, Biologic and Molecular Characteristics of Patients with Myeloproliferative Neoplasms and a Chronic Myelomonocytic Leukemia-Like Phenotype. (cdc.gov)
INTRODUCTION - An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. (medilib.ir)

[ 14 ] To date, 2 patients with LEOPARD syndrome and myelomonocytic or acute lymphoblastic leukemias have been reported. (medscape.com)
Importantly, however, not all patients with LEOPARD syndrome demonstrate linkage to 12q24.1. (medscape.com)
Humanigen believes that GM-CSF neutralization with lenzilumab also has the potential to reduce the hyper-inflammatory cascade known as cytokine release syndrome common to chimeric antigen receptor T-cell (CAR-T) therapy and acute Graft versus Host Disease (aGvHD). (businesswire.com)
In CAR-T, lenzilumab successfully achieved the pre-specified primary endpoint at the recommended dose in a Phase 1b study with Yescarta® in which the overall response rate was 100% and no patient experienced severe cytokine release syndrome or severe neurotoxicity. (businesswire.com)
Acute lymphoblastic leukaemia in Noonan syndrome. (lu.se)

Abstract: Objective: This study aimed to estimate adherence to methotrexate in patients with rheumatoid arthritis and identify specific nonadherence risk factors. (preprints.org)
Leukemia 2008(5): 1075-8 [ PubMed abstract ]. (lu.se)
Leukemia 2007(6): 1303-5 [ PubMed abstract ]. (lu.se)
Leukemia 2006(6): 1155-8 [ PubMed abstract ]. (lu.se)

Current treatment for inv(16) AML uses chemotherapy drugs, such as doxorubicin and cytarabine, with an estimated 5-year overall survival of 60% in young patients and only 20% in the elderly. (wikipedia.org)
The acute leukemia is resistant to conventional chemotherapy. (medscape.com)
The purpose of this study is to compare the effectiveness of two multi-agent chemotherapy regimens using different dosages of cytarabine to eliminate all detectable leukemia. (stanford.edu)
However, reliance upon PURINETHOL alone is not justified for initial remission induction of acute lymphatic leukemia since combination chemotherapy with vincristine, prednisone, and L-asparaginase results in more frequent complete remission induction than with PURINETHOL alone or in combination. (druglib.com)

in turn, each of these categories is classified as either acute or chronic, depending on the proportion of morphologically and immunophenotypically immature precursors (blasts) in the bone marrow or peripheral blood. (medilib.ir)

We used real-time RT-PCR to compare PU.1 expression between de novo APL patient samples and normal blood specimens, and the results indicated that PU.1 expression was significantly lower in newly diagnosed APL patient samples as compared to normal hematopoietic cells. (biomedcentral.com)

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. (ucbraid.org)
APOBEC3 in Pediatric Leukemia: a Biomarker for Sensitivity to PARP Inhibition? (alexslemonade.org)

Although a 2-hit model is present in most patients with 7q uniparental disomy and a myeloproliferative phenotype, haplodeficient expression of defined regions of 7q may underlie pathogenesis in patients with deletions and predominant dysplastic features. (elsevierpure.com)

Mutational landscape of chronic myelomonocytic leukemia and its potential clinical significance. (cdc.gov)
Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)

GFI1B-D262N promoted myelomonocytic versus erythroid output from primary human hematopoietic precursors and enhanced cell survival of both normal and MDS derived precursors. (lu.se)
Most of the MN patients (77.3%) received hypomethylating agents with unsatisfactory response, and four had allogeneic hematopoietic stem cell transplantation (HSCT). (bloodcancerstoday.com)
The drug candidate is also under development for bone marrow conditioning before a hematopoietic stem cell transplant (HSCT), in relapsed/refractory elderly AML patients. (pharmaceutical-technology.com)
Acute myeloid leukemia (AML) is a malignant disorder of the hematopoietic stem cells characterized by abnormal proliferation of myeloid blast cells in the bone marrow and blood, preventing them from further differentiating into the specialized cells of the bone marrow and thus causing pancytopenia. (dovepress.com)

Reporting in the April 20, 2020 online edition of the journal Nature Cancer , Reya and colleagues identified RNA-binding proteins -- which normally control how, when and if cells make certain proteins -- as a key class of proteins that sustain and protect drug-resistant leukemia stem cells. (sciencedaily.com)
3 The study began in October 2020 and was comprised of hospitalized patients who need medical care for COVID-19 pneumonia and randomized (1:1) to the treatment groups. (businesswire.com)
ASH 2020: - Phase 3 Study of Lenalidomide (LEN) Vs. Placebo in Non-Transfusion Dependent (TD) Low Risk Del(5q) MDS Patients - Interim Analysis of the European Sintra-REV Trial. (sehh.es)

26% of chronic myelomonocytic leukemia patients harbored 7q uniparental disomy, of which 41% had a homozygous EZH2 mutation. (elsevierpure.com)

The RUNX1 and CBFB genes are targets of chromosome rearrangements that create oncogenic fusion genes in leukemia. (wikipedia.org)
The chromosome translocation t(12;21) (p13.1;q22) causes the fusion of the ETS variant 6 (ETV6) and RUNX1 genes results in ETV6-RUNX1 gene fusion and is the most common genetic aberration in childhood acute lymphoblastic leukemia (ALL). (wikipedia.org)
We used CRISPR technology to carry out a genome-wide screen in leukemia cells to block thousands of genes at once. (sciencedaily.com)
This is an extremely powerful tool that allowed us to identify a multitude of genes that fuel leukemia growth and find new vulnerabilities that can be targeted in this disease," said senior author Tannishtha Reya, PhD, professor in the departments of Pharmacology and Medicine. (sciencedaily.com)
RNA-sequencing was performed in bone marrow mononuclear cells from BCOR MUT and BCOR WT patients and revealed 2030 upregulated and 772 downregulated genes. (biomedcentral.com)
Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes. (atlasgeneticsoncology.org)

On the other hand, expression of survivin was undetectable in the 4 patients with chronic myelomonocytic leukemia (CMMoL). (spandidos-publications.com)

The current study used APL patient samples to assess the expression pattern of PU.1 in the initiation and progression of APL. (biomedcentral.com)
Our findings provide evidence that low PU.1 expression in APL patients is required for disease initiation and progression. (biomedcentral.com)

OUTLINE: All patients receive elutriated, CD34+ stem cell augmented donor bone marrow according to another protocol on day 0. (knowcancer.com)
Acute lymphoblastic leukemia (ALL) is a malignant expansion of lymphoblasts in the bone marrow, blood, and extramedullary tissues [ 1 ]. (karger.com)
There are several different types of leukemia, or cancer of the blood-forming tissues such as bone marrow. (gallivanlawfirm.com)
Since leukemia develops in the bone marrow, doctors will typically sample the patient's bone marrow via a bone marrow aspiration and a bone marrow biopsy. (gallivanlawfirm.com)
Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults. (ucbraid.org)
In contrast, other studies using targeted sequencing of children with idiopathic bone marrow failure or MDS found pathogenic variants in only approximately 10% of patients 16 , suggesting the need for more comprehensive sequencing. (nature.com)
patients (pts) without CR are considered non-responders, and hematologic improvement (HI) without bone marrow blast (BMB) clearance is considered treatment (trt) failure (Cheson 2003). (kl.ac.at)
Leukemia starts in blood-forming tissues such as the bone marrow. (medlineplus.gov)
When you have leukemia, your bone marrow makes large numbers of abnormal cells. (medlineplus.gov)
Leukemia happens when there are changes in the genetic material (DNA) in bone marrow cells. (medlineplus.gov)

The present study demonstrated the biological and functional evidence for the critical role of RUNX1 -MT in ASXL1 -mutated leukemia in the pathogenesis of myeloid malignancies. (biomedcentral.com)
The study will enroll pediatric patients who undergo myeloablative HCT for hematologic malignancies at PBMTC sites. (ucbraid.org)

Ganti AK, Subbiah SP, Kessinger A, Gonsalves WI, Silberstein PT, Lobriza FR Jr. Association between Race and Survival of Patients with Non-Small Cell Lung Cancer in The United States Veterans Affairs Population:Clinical Lung Cancer-2014 Mar;15(2):152-8. (creighton.edu)
Treatment patterns, and survival of patients with metastatic undifferentiated pleomorphic sarcoma: A National Cancer Database (NCDB) study. (creighton.edu)
A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse. (sciencedaily.com)
According to the National Cancer Institute, approximately 1.5 percent of men and women will be diagnosed with leukemia at some point during their lifetimes. (sciencedaily.com)
In some leukemias, a shortage of white blood cells can make the patient vulnerable to various infections, and platelet shortages can result in frequent bleeding or bruising, according to the American Cancer Society . (gallivanlawfirm.com)
Our researchers have made protocol-defining discoveries that have changed the way doctors treat testicular cancer, breast cancer, gastrointestinal cancer, genitourinary cancer, leukemia, multiple myeloma, thymoma and thymic carcinomas, and thoracic cancer. (clinicaltrialsgps.com)
Taking Care of Your Health features cancer-related information, health tips, patient stories and more. (moffitt.org)
The Children's Cancer Group 1952 (CCG-1952) clinical trial studied the substitution of oral 6-thioguanine (TG) for 6-mercaptopurine (MP) and triple intrathecal therapy (ITT) for intrathecal methotrexate (IT-MTX) in the treatment of standard-risk acute lymphoblastic leukemia. (druglib.com)
This study was performed to determine the feasibility and reproducibility of a ExeCMR + CPET technique to measure the Fick components of peak oxygen consumption (VO 2 ) and pilot its discriminatory potential in hematologic cancer patients experiencing fatigue. (biomedcentral.com)
Which type of leukemia you have depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. (medlineplus.gov)

The recommendations are applicable only to immunocompetent adult patients with IPF. (atsjournals.org)
The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric patient or adult). (druglib.com)
however, some develop adult T cell leukemia. (symptoma.com)

As a single agent, PURINETHOL will induce complete remission in approximately 10% of pediatric patients and adults with acute myelogenous leukemia or its subclassifications. (druglib.com)

MPNs include polycythemia vera, essential thrombocythemia, chronic myeloid leukemia (CML), primary myelofibrosis, chronic neutrophilic leukemia, and other less well defined entities such as chronic eosinophilic leukemia, not otherwise categorized. (medilib.ir)
Less frequently, patients with polycythemia vera develop myocardial infarction, stroke, venous thrombosis and congestive heart failure . (symptoma.com)

This led to the discovery that this protein controls key oncogenes, such as Ras, and epigenetic regulators, such as the LSD/KDM family of proteins, which are critical drug targets being tested against leukemia and other cancers. (sciencedaily.com)
The findings also have implications for acute myeloid leukemia (AML) and other blood cancers. (sciencedaily.com)
Leukemia is a term for cancers of the blood cells. (medlineplus.gov)

Not all of the findings are present in any given patient. (medscape.com)
Subsequent communications added new findings in isolated patients or families. (medscape.com)
Overall, these findings validate inhibition of RUNX1- CBFβ-SMMHC protein-protein interaction as a novel therapeutic avenue for leukemia with inv(16) and AI-10-49 as a specific inhibitor of CBFβ-SMHHC oncoprotein. (wikipedia.org)
Findings consistent with chronic myelomonocytic leukemia have been noted in at least several patients. (medscape.com)
The researchers, who presented their findings at the 64th American Society of Hematology Annual Meeting & Exposition, said the results support the World Health Organization's proposal to reclassify these types of MNs into acute myeloid leukemia (AML), regardless of blast counts, so that these patients can benefit from more intensive treatments. (bloodcancerstoday.com)
We also observed that using steroids in DL-positive patients did not significantly impact their recovery.Our findings support the limited published data on PCH patients and further prompt larger multicenter studies to further characterize these patients so that they are more readily identified, especially in centers where DL antibody testing is not readily available. (stanford.edu)

A significant interaction between the treatment arm and the FLT3-ITD mutation was found, and high-dose daunorubicin was more effective than idarubicin in patients with FLT3-ITD mutation. (ascopost.com)

Some patients may receive peripheral blood smears, blood chemistry tests, blood coagulation tests, flow cytometry, and immunohistochemistry tests. (gallivanlawfirm.com)
We used immunofluorescence flow cytometry in analyzing whole blood and isolated neutrophils from 49 MDS patients, 33 men and 16 women aged 33 to 85 years (median, 75 years), and 18 healthy individuals aged 35 to 80 years (median, 72 years). (elsevierpure.com)

No prior therapy for this malignancy (patients with secondary AML following treatment of primary malignancy are eligible) except for one dose of intrathecal therapy. (stanford.edu)
AML-M4 with no morphologic arguments for a secondary leukemia. (atlasgeneticsoncology.org)

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). (bvsalud.org)

Given as a single agent for remission induction, PURINETHOL induces complete remission in approximately 25% of pediatric patients and 10% of adults. (druglib.com)

There is significant clinical heterogeneity in patients with RUNX1-FPDMM. (eviq.org.au)
This was confirmed by nested PCR amplification of reverse-transcribed RNA from the patients BM cells, which detected a 245 bp-long USP16-RUNX1 transcript. (atlasgeneticsoncology.org)
The break/fusion was not present in the germline since we did not find the USP16-RUNX1 transcript in buccal smear cells of the patient. (atlasgeneticsoncology.org)

Furthermore, we measured PU.1 expression in APL-initiating cells isolated from de novo APL patients by side population cell analysis and found that suppression of PU.1 expression occurred concurrently with PML-RARα expression, indicating the pivotal role of PU.1 in APL initiation. (biomedcentral.com)
Out of 12 patients with de novo AML, 5 patients (41.7%) showed detectable levels of survivin expression. (spandidos-publications.com)

Benefits of the intermittent use of 6-mercaptopurine and methotrexate in maintenance treatment for low-risk acute lymphoblastic leukemia in children: randomized trial from the Brazilian Childhood Cooperative Group--protocol ALL-99. (druglib.com)

He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)

With a median follow-up of 23 months (range = 1-43 months), the overall response rate was 38% for patients receiving azacitidine, 49% for azacitidine plus lenalidomide (P = .14 vs azacitidine), and 27% for azacitidine plus vorinostat (P = .16 vs azacitidine). (ascopost.com)
For patients with chronic myelomonocytic leukemia, the overall response rate was higher for azacitidine plus lenalidomide vs azacitidine alone (68% vs 28%, P = .02) but similar for all arms across cytogenetic subgroups, as was remission duration and overall survival. (ascopost.com)
On July 26, the second azacitidine treatment was not administered because the patient again experienced febrile aplasia. (cdc.gov)

Eight of 14 BCOR MUT patients (57.1%) achieved complete remission (CR) with decitabine treatment, which was much higher than that in BCOR WT patients (28.7%, p = 0.036). (biomedcentral.com)
The duration of complete remission induced in acute lymphatic leukemia is so brief without the use of maintenance therapy that some form of drug therapy is considered essential. (druglib.com)

Durable Response to Crizotinib in a Patient with Pulmonary Adenocarcinoma Harboring MET Intron 14 Mutation: A Case Report. (cdc.gov)
In this assay, the similarities and differences of the BCOR mutation features of a large cohort (676 total patients) of Chinese MDS patients were analyzed and compared to the results in the existing literature. (biomedcentral.com)
Ultimately, 64% of patients with MN and NPM1 mutation transformed to AML in a median 21.1 months. (bloodcancerstoday.com)
However, JAK2 V617F mutation analysis has revealed that patients with "polyclonal" essential thrombocythemia might also display the mutation [ 12 ]. (medilib.ir)

Leukemia is a malignant disease that attacks leukocytes. (bvsalud.org)

One of the most important procedures is a careful history taking to collect information on any previous3 history of bleeding episodes occurred with the patient and/or family, the use of medication that interferes with coagulation, coagulopathies, and specific systemic diseases, such as arterial hypertension, liver diseases and leukemia. (bvsalud.org)

Ophthalmic manifestations of leukemia are more frequent with acute than chronic leukemia and can affect all intraocular structures. (dovepress.com)
Patients with a history of hematoma or hemorrhage are a frequent problem in emergency rooms. (bvsalud.org)

PURINETHOL (mercaptopurine) is indicated for remission induction and maintenance therapy of acute lymphatic leukemia. (druglib.com)
Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia. (druglib.com)
however, grade IV liver toxicity occurred more often in the patients receiving 6-MP/MTX with VCR and DEX therapy than in patients receiving LSA2L2. (druglib.com)
Adverse events were more common among patients on active therapy. (druglib.com)
Here we describe the case of a patient with CML who developed monosomy 7 in Ph(-) cells during dasatinib therapy. (lu.se)

Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. (nature.com)

Anatomy37

Organisms19

Diseases59

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes52

Disciplines and Occupations1

Information Science5

Health Care7

Myelodysplastic syndrome4

CMML12

Mutations25

Promyelocytic leukemia3

Juvenile7

Diagnosis12

Transformation4

Refractory anemia2

Clonal6

Lymphoma5

PTPN113

Lymphocytic leukemia4

Lymphomas5

Myeloproliferative neoplasms2

Syndrome5

Abstract4

Chemotherapy4

Blasts1

Newly diagnosed1

Pediatric leukemia2

Phenotype1

Mutational2

Hematopoietic4

20203

Uniparental disomy1

Genes6

CMMoL1

Progression2

Marrow10

Malignancies2

Cancer10

Adult3

Myelogenous1

Polycythemia vera2

Cancers3

Findings6

FLT31

Flow cytometry2

Secondary2

CHARACTERISTICS1

Adults1

RUNX13

Novo2

Childhood1

Clinical Trials1

Azacitidine3

Complete remission2

Mutation4

Malignant1

Systemic1

Frequent2

THERAPY5

Somatic1