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  • cell malignancy
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • pediatric
  • In her first decade as a pediatric oncologist, Dr. Symons already has shown an impressive ability to juggle multiple research projects, in addition to caring for patients. (hopkinsmedicine.org)
  • To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
  • Nonmyeloablative
  • Nonmyeloablative conditioning regimen: Patients receive fludarabine IV over 30 minutes on days -6 to -2 and cyclophosphamide IV over 1-2 hours on days -6 and -5. (knowcancer.com)
  • severe
  • The patients enrolled in these studies have varying risks, from those with hematologic malignancies where invasive fungal infection is a substantial concern, to solid organ malignancies receiving less intense chemotherapy where the problem is not as severe. (acpjc.org)
  • Cyclophosphamide decreases the immune system's response, and although concerns about toxicity restrict its use to patients with severe disease, it remains an important treatment for life-threatening autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. (wikipedia.org)
  • transplants
  • Such non-myeloblative (also called reduced intensity or "mini") transplants can be used in older and less fit patients who are not candidates for high-dose myeloablative conditioning. (oncologynurseadvisor.com)
  • treatment
  • Patients are randomized to 1 of 2 treatment arms. (clinicaltrials.gov)
  • Treatment of these patients can be optimized under shared care arrangements that enable referring physicians to manage long-term administration of immunosuppressive medications and supportive care with guidance from transplant center experts. (bloodjournal.org)
  • BMT is part of the treatment paradigm of most hematologic malignancies. (oncologynurseadvisor.com)
  • Osteonecrosis (ON) is recognised as a complication of the treatment of hematologic malignancies in children and adolescents. (hindawi.com)
  • 7 trials involving 1153 patients compared drugs absorbed from the gastrointestinal (GI) tract (fluconazole, ketoconazole, and itraconazole) with placebo or a no-treatment control and found that fewer patients receiving the active drugs developed oral candidiasis (Table). (acpjc.org)
  • 8 studies involving 382 patients compared drugs not absorbed from the GI tract (e.g., amphotericin B, nystatin, and chlorhexidine) with placebo or a no-treatment control and found that these active drugs did not appear to be as effective in preventing oral candidiasis (Table). (acpjc.org)
  • However, nivolumab had to be discontinued in one patient due to development of immune-related polyarthritis requiring treatment with systemic corticosteroids and methotrexate. (biomedcentral.com)
  • For example, many patients in the landmark studies of MOPP treatment for Hodgkin's disease were treated at the BCRC. (wikipedia.org)
  • Formerly, the only treatment option that offered relapsed bone marrow transplant patients hope of a cure was another bone marrow transplant. (wikipedia.org)
  • If you have 100 patients and you have a treatment applicable to 20 of the 100, and 20% of those 20 are alive after 10 years, that's only a 4% absolute survival rate, not a 20% survival rate. (wikipedia.org)
  • The center is staffed by nationally and internationally recognized experts who have made major clinical and research advances in the treatment of childhood malignancies. (wikipedia.org)
  • Lenalidomide was approved on June 17, 2013 by the European Medicines Agency for use in low- or intermediate-1-risk myelodysplastic syndromes (MDS) patients who have the deletion 5q cytogenetic abnormality and no other cytogenetic abnormalities, are dependent on red blood cell transfusions, and for whom other treatment options have been found to be insufficient or inadequate. (wikipedia.org)
  • Lymphocytes
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • lymph nodes
  • Symptoms of Richter's transformation in a CLL patient include fever (without infection), an elevated serum levels of lactate dehydrogenase, and rapidly enlarging lymph nodes. (wikipedia.org)