MalignanciesSickle cell diMalignancyDisordersPulmonaryHematologyDiagnosisGeneticAcuteRenalHematological diseasesSymptomsOutcomesPrognosisTherapiesCentersRemissionAplastic2020CancersHyaluronidase-fihj2019Graft versusUnderwentSystemicAutoimmuneInfectious diseasesCardiovascular diseasesMyeloproliferative diseaseTreatmentCoronary arteryManifestation of the diseaseSurvivalSplenicThrombocytopeniaCardiacAplasiaChemotherapyInvasiveSplenomegalyCancerPipelineInflammatoryOncologicalHospitalized COVID-19ConsortiumKidney diseaseRadiographic findingsInfectionsChronic diseasesPrevalenceAdultRareCoronavirusGastrointestinalConditionsMedicinesRefractoryRegimenAbnormal
Malignancies5
- should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic malignancies. (cdc.gov)
- We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH 2021," said Peter Lebowitz, M.D., Ph.D., Global Therapeutic Area Head, Oncology, Janssen Research & Development, LLC. (jnj.com)
- Patients with hematological malignancies (HMs) are at a continuous risk for immunodeficiency, related either to the own malignancy or to the associated therapies, such as antineoplastic drug administration or hematopoietic stem-cell transplantation (HSCT). (lww.com)
- Through the Hematologic Malignancies Program , they also research the causes of blood cancers and translate the latest findings into cutting-edge treatments and clinical trials. (mayoclinic.org)
- Analysis of operative indications in the series of Nores et al revealed that patients with hematologic conditions were typically explored for complications of those conditions (69%), especially patients with nonmalignant conditions (90%), whereas patients with hematologic malignancies often (47%) underwent surgery for acute symptoms. (medscape.com)
Sickle cell di7
- sickle cell disease. (wikipedia.org)
- However, there is a lack of evidence from trials showing that splenectomy improves survival and decreases morbidity in sickle cell disease. (medscape.com)
- ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
- Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
- However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
- Her areas of clinical interest include sickle cell disease and bleeding disorders. (chiaonline.org)
- Many of the altitude-related episodes in patients with sickle cell disease can be safely treated with supportive care rather than with splenectomy. (medscape.com)
Malignancy1
- Of those, 34 patients (50%) had an underlying malignancy, of which more than half were splenic marginal zone lymphoma. (medscape.com)
Disorders9
- Low-dose radiotherapy has been used as palliative care for splenomegaly in patients with hematologic disorders such as primary myelofibrosis. (medscape.com)
- In a review by Zaorsky et al that included 766 courses of splenic irradiation for 486 patients from 1960 to 2016, the most common cancers treated included chronic lymphocytic leukemia and myeloproliferative disorders. (medscape.com)
- Hematologic changes in patients with liver disease are generally nonspecific and overlap with many other systemic disorders. (merckvetmanual.com)
- Enteric hemorrhage in advanced-stage liver disease or other disorders causing splanchnic hypertension is most often first encountered during the interval of decompressive compensation (ie, when acquired portosystemic shunts are developing ~4-6 weeks from onset of splanchnic hypertension). (merckvetmanual.com)
- Rigel works with novel small molecule drugs for hematologic disorders, cancer, and rare immune diseases. (pennystocks.com)
- Also contributing to this market shift are the development of "lifestyle" drugs and other medications for newly discovered and sometimes vaguely defined disorders or disease syndromes that, heretofore, may have been traditionally considered part of the human living experience and aging process. (pharmacytimes.com)
- There are now more than 7000 rare diseases recognized by the various organizations and governmental agencies that track, provide support, and coordinate research for the diagnosis and treatment of these disorders and diseases. (pharmacytimes.com)
- Among 43 patients with psychological disorders, 51.16% were female, 62.79% developed anxiety 32.56% developed insomnia and 20.93% developed depression. (bvsalud.org)
- To determine the knowledge level of undergraduate dentistry students of UESB on hematological disorders and their implications in the treatment of the patient. (bvsalud.org)
Pulmonary6
- Filamentous Basidiomycetes molds are ubiquitous and able to colonize in patients with chronic pulmonary disease. (cdc.gov)
- Acceleron's lead therapeutic candidate, sotatercept, has a novel mechanism of action with the potential to improve short-term and/or long-term clinical outcomes in patients with pulmonary arterial hypertension (PAH), a progressive and life-threatening blood vessel disorder. (pharmiweb.com)
- In preclinical models of PAH, sotatercept reversed pulmonary arterial wall and right ventricular remodeling that are hallmarks of the disease. (pharmiweb.com)
- A Phase 2 trial (PULSAR) evaluating sotatercept in combination with approved PAH-specific medicines in patients with PAH met its primary endpoint of improvement in pulmonary vascular resistance. (pharmiweb.com)
- The consortium's goal, the NIH said, is to translate recent advances in progenitor cell biology, including those made by the NHLBI's Progenitor Cell Biology Consortium and the Lung Repair and Regeneration Consortium , to develop new treatments for cardiovascular, pulmonary, and hematologic diseases. (genomeweb.com)
- Pulmonary tuberculosis in patients with HTLV-III/LAV infection cannot readily be distinguished from other pulmonary infections, such as Pneumocystis carinii pneumonia, on the basis of clinical and radiographic findings. (cdc.gov)
Hematology6
- DARZALEX FASPRO , as the first and only FDA-approved treatment for newly diagnosed AL amyloidosis, marks a significant advance for a disease with high unmet medical need," said Jessica Vermeulen , M.D., Ph.D., Global Medical Head/Clinical Leader, Hematology & Oncology, Janssen Research & Development, LLC. (biospace.com)
- The cases were patients with diagnosis of aplastic anemia confirmed through biopsy or bone marrow aspiration, selected through an active search of clinical laboratories, hematology clinics and medical records. (haematologica.org)
- Crosswicks, NJ - (December10, 2008) - The Myelodysplastic Syndromes (MDS) Foundation announced today that data presented at this year's American Society of Hematology (ASH) Meeting in San Francisco demonstrate that patients with acute myeloid leukemia (AML) who were treated with VIDAZA (azacitidine) had significantly increased overall survival compared to those treated with conventional care regimens (CCR). (eurekalert.org)
- From the most common to incredibly rare hematologic diseases, hematology specialists at Mayo Clinic use the latest technology and information to work with you to diagnose your condition. (mayoclinic.org)
- At Mayo Clinic Hematology, we understand that each blood cancer is unique and that two people with the same diagnosis can actually have very different diseases. (mayoclinic.org)
- This retrospective study was conducted at the Institute of Hematology & Blood Diseases Hospital, for hospitalized MDS patients diagnosed (WHO 2008 classification criteria) from May 2006 to February 2020. (medscimonit.com)
Diagnosis12
- 2 ,3 About one-third of patients visit five or more doctors before receiving a diagnosis, and 72 percent are diagnosed more than one year after they first experience symptoms. (biospace.com)
- 3,4 Patients often have a poor prognosis due to the delay in diagnosis of AL amyloidosis, which frequently presents with non-specific symptoms that can mimic other, more common conditions. (biospace.com)
- 7 As many as 30 percent of patients with AL amyloidosis die within the first year after diagnosis. (biospace.com)
- In the case of chronic multisystem polymorbidity systemic mast cell activation disease should be considered as a differential diagnosis at an early stage. (thieme-connect.com)
- Although rapid confirmation of genetic diagnosis is mandatory, patients in whom APL is suspected (on the basis of clinical presentation and peripheral blood smear results) should be immediately hospitalized and their case managed as a medical emergency. (medscape.com)
- The diagnosis of eosinophilic fasciitis is suspected in a patient presenting with characteristic skin changes and consistent laboratory findings. (medscape.com)
- So being able to harness the expertise of multiple specialists in an efficient and condensed interval of time really allows us to help take the whole patient into account, make the right diagnosis, identify the right treatment, and get it started as quickly as possible. (mayoclinic.org)
- However, timely and accurate diagnosis, the use of effective treatment and maintenance therapies, and known prognoses for these patient populations are often challenging due to a number of factors. (pharmacytimes.com)
- These challenges include access to, and validation of, clinical knowledge for a timely and effective diagnosis, treatment and maintenance therapies, and long-term prognosis due to very limited patient populations and individual provider expertise within each disease state. (pharmacytimes.com)
- Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)
- Clinicians should consider the diagnosis of tuberculosis in patients with, or at risk of, HTLV-III/LAV infection, even if the clinical presentation is unusual (4,13,14). (cdc.gov)
- It was observed that the patient had psychological suffering from the diagnosis until the end. (bvsalud.org)
Genetic4
- Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics. (thieme-connect.com)
- Autoimmune diseases are more commonly caused by genetic, infectious or environmental factors. (medgadget.com)
- Although rare diseases vary widely in their clinical symptoms and disease progression, most have a strong genetic basis in common. (pharmacytimes.com)
- Approximately 80% of rare diseases are caused by a genetic defect, and these diseases are often categorized according to their clinical system impact. (pharmacytimes.com)
Acute8
- Acute myeloid leukemia (AML) is an aggressive heterogeneous hematologic disease with high mortality in patients older than 60 years. (confex.com)
- It is not known exactly how many people have MDS, however, about 20,000 to 25,000 new cases are diagnosed annually in the U.S. In addition, roughly 30 percent of patients diagnosed with MDS will progress to acute myeloid leukemia (AML). (eurekalert.org)
- This is in direct contrast to the last several decades in which the development of medications for acute or chronic disease states, affecting millions of patients, was the primary target for the pharmaceutical industry. (pharmacytimes.com)
- Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)
- COVID-19 is an acute respiratory disease originally from China that emerged in December 2019 and quickly spread around the world, affecting 230,418.415 people, and causing 4,724,876 deaths. (bvsalud.org)
- while reading the studies, it was concluded that Acute Kidney Injury was the main renal finding in patients contaminated by SARS-CoV-2. (bvsalud.org)
- The majoritary findings concluded that Acute Kidney Injury (AKI) was the main renal finding in patients contaminated by SARS-coV-2, follow by the risk factors identified for developing renal worsening in patients with COVID-19, like the extremes of age, race, sex, pre-existing diseases and disease evolution. (bvsalud.org)
- COVID-19 is an acute respiratory disease caused by SARS-CoV-2 that has spread rapidly around the world, originating in Hubei Province, Wuhan, China, in December 2019. (bvsalud.org)
Renal3
- 5 Calciphylaxis causes painful, stellate ulcerations with necrotic eschar and is usually seen in the setting of end-stage renal disease in patients with abnormal calcium and phosphate metabolism. (clinicaladvisor.com)
- The risk factors for developing renal worsening in patients with COVID-19 were the extremes of age, race, sex, pre-existing diseases, and the disease evolution. (bvsalud.org)
- The renal involvement does not occur only for an exclusive reason, but as a set of factors surrounding the corse of the desease and the biological profil of the patient. (bvsalud.org)
Hematological diseases2
- Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
- Many of our hematological diseases evolve rapidly and need rapid intervention. (mayoclinic.org)
Symptoms7
- Sadly, most patients with AL amyloidosis are diagnosed more than one year after their initial symptoms present, at a time when they may already be experiencing organ deterioration or failure. (biospace.com)
- However, due to th e limited sensitivities and predictive values of RIDTs, negative results of RIDTs do not exclude influenza virus infection in patients with signs and symptoms suggestive of influenza. (cdc.gov)
- Some may have no symptoms, mild symptoms or severe disease. (who.int)
- People with mild symptoms of both diseases can usually be treated safely at home. (who.int)
- The indications that warrant surgical intervention include hematologic complications for the underlying disease process and persistent symptoms, such as sepsis, abscess, hemorrhage, or persistent pseudocyst formation. (medscape.com)
- Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (medscape.com)
- o Signs or symptoms consistent with active TB disease. (cdc.gov)
Outcomes5
- Outcomes are usually worse in patients who require blood transfusions compared to those who can have alternative therapies. (wikipedia.org)
- Furthermore, severe PE is a major cause of maternal morbidity (i.e., stroke and liver rupture) and negative long-term outcomes (i.e., cardiovascular disease and diabetes mellitus) as well as adverse perinatal effects, such as prematurity and intrauterine growth restriction [ 5 , 10 ]. (hindawi.com)
- Sepsis programs can coordinate these efforts to optimize patient outcomes. (cdc.gov)
- These data highlight opportunities, particularly in smaller hospitals, to improve the care and outcomes of patients with sepsis in the United States by ensuring that all hospitals have sepsis programs with protected time for program leaders, engagement of medical specialists, and integration with antimicrobial stewardship programs. (cdc.gov)
- This Viewpoint discusses Hospital Sepsis Program Core Elements, a set of guidance provided by the Centers for Disease Control and Prevention to help hospitals develop multiprofessional programs that monitor and optimize management and outcomes of sepsis. (cdc.gov)
Prognosis3
- However, an association with several hematologic diseases is recognized and frequently carries a grave prognosis. (medscape.com)
- Patients with AML typically have a poor prognosis and do not respond well to conventional chemotherapy. (eurekalert.org)
- HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
Therapies5
- We are committed to bringing important therapies to patients with high unmet needs and feel that Ac-225 has the potential to be an optimal warhead when applied in a targeted manner as we do. (prnewswire.com)
- Actinium is advancing the only multi-disease, multi-target, clinical-stage pipeline for targeted conditioning to enable cellular therapies such as BMT or Bone Marrow Transplant (BMT) and CAR-T. The target market for Actinium's ARC or Antibody Radiation Conjugate drug candidates is concentrated within the top 75-100 hospitals in the U.S. that perform a majority of BMT and CAR-T procedures. (prnewswire.com)
- Today's approval underscores our commitment to deliver innovative therapies for patients with plasma cell diseases. (biospace.com)
- As evidenced by our presence at ASH, we are continuously pushing boundaries to treat cancer," said Serge Messerlian, U.S. President, Oncology, Janssen Biotech, Inc. "At ASH, we look forward to working with the oncology community to advance the understanding and use of novel treatments and address unmet patient needs, with the ultimate goal of developing curative therapies. (jnj.com)
- The data presented at this year's ASH Meeting are encouraging for both physicians and patients and demonstrate the major advancements that have been made in treating hematologic conditions, like MDS and AML, over the past several years," said Kathy Heptinstall, Operating Director of the Myelodysplastic Syndromes Foundation, "We are hopeful about the potential of novel therapies, like VIDAZA, which are helping patients to live longer with a better quality of life. (eurekalert.org)
Centers2
Remission1
- The data presented today are a follow-up to results from the AZA-001 trial presented at the American Society of Clinical Oncology Meeting in June, which showed that patients with high-risk MDS who received VIDAZA had higher one-year survival rates in all response categories, including partial remission, stable disease and hematologic improvement, compared to those who received CCR without necessarily achieving complete remission. (eurekalert.org)
Aplastic3
- The controls did not have either aplastic anemia or chronic diseases. (haematologica.org)
- A total of 224 patients with aplastic anemia were included in the study, each case was paired with four controls, according to sex, age group, and hospital where the case was first seen. (haematologica.org)
- Aplastic anemia (AA) is a hematologic condition characterized by bone marrow hypoplasia or aplasia resulting in pancytopenia. (haematologica.org)
20203
- Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. (scielo.br)
- In January 2020, the World Health Organization (WHO) declared the outbreak of COVID-19 as the sixth public health emergency of international attention, in which health workers, governments and the general population in order that the spread of the disease was prevented. (bvsalud.org)
- The spread of the disease occurred rapidly and exponentially, reaching almost all countries and, even with the attempt to contain the disease, the WHO declared in March 2020, a pandemic caused by SARS-CoV-2 2-4 . (bvsalud.org)
Cancers1
- The development of bosutinib is evidence of our commitment to bringing meaningful new medicines to patients with hematologic cancers,' said Mace Rothenberg, MD, senior vice president of Clinical Development and Medical Affairs, Pfizer Oncology Business Unit. (aol.com)
Hyaluronidase-fihj1
- Jan. 15, 2021 /PRNewswire/ -- The Janssen Pharmaceutical Inc. Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) approval of DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj), a subcutaneous formulation of daratumumab, in combination with bortezomib, cyclophosphamide and dexamethasone (D-VCd) for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis. (biospace.com)
20191
- 9 As the situation rapidly evolved the coronavirus disease 2019 (COVID-19) pandemic commenced. (lww.com)
Graft versus1
- Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
Underwent1
- Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
Systemic8
- In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. (thieme-connect.com)
- The reader should be able to recognize and diagnose a systemic mast cell activation disease, as well as to counsel a personalized drug therapy. (thieme-connect.com)
- ASXL1 but Not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. (thieme-connect.com)
- Systemic mastocytosis - definition of an internal disease. (thieme-connect.com)
- Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)
- Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. (asahq.org)
- Several systemic and skin diseases are associated with pruritus. (asahq.org)
- We also wanted to summarize the up-to-date knowledge about systemic diseases that have pruritus as a symptom and may be associated with an increase in the incidence of pruritus in the perioperative period. (asahq.org)
Autoimmune2
- The risk of development of autoimmune diseases has been linked to host genetics, and a few risk factors have been identified that affect the immune response and the susceptibility of the hematopoietic target cell. (haematologica.org)
- Autoimmune Disease Therapeutics Market - Autoimmune diseases is a body's hyperactive immune response against the substances and tissues normally present in the body. (medgadget.com)
Infectious diseases1
- Baseline immunosuppression can be the main predisposing condition for the development of infectious diseases caused by different pathogens, such as bacteria, 1 , 2 fungi, 3 , 4 or viruses. (lww.com)
Cardiovascular diseases2
- Finally, circulating NPM was increased in the plasma of 29 Pso compared to 29 healthy controls, and positively correlates with psoriasis area severity index (PASI) and with determinants of cardiovascular diseases (CVDs), such as pulse wave velocity, systolic pressure, and left ventricular mass. (frontiersin.org)
- Peptide therapeutics are witnessing substantial demand, owing to increasing application in the treatment of various chronic disease such as cancer, cardiovascular diseases, hematologic diseases, and gastro-intestinal diseases. (medgadget.com)
Myeloproliferative disease1
- In this setting, splenomegaly is thought to reflect work hypertrophy that results from the removal of abnormal blood cells from the circulation (either cells with intrinsic defects or cells coated with antibody) or, in some cases, that results from extramedullary hematopoiesis (ie, myeloproliferative disease). (medscape.com)
Treatment20
- During the course of initial treatment some patients may never respond, may develop drug-resistant disease or may not be able to tolerate their therapy. (aol.com)
- We believe that bosutinib, if approved by the European Commission, would represent an important option for patients with CML who have progressed on prior treatment and are not candidates for alternative treatments. (aol.com)
- We believe many doctors and CML patients will find this treatment, if approved, to be a welcome addition, offering a distinct adverse event profile and a convenient once-daily dosing regimen. (aol.com)
- 4 Bosutinib was first approved as BOSULIF ® in the United States (U.S.) in September 2012 for the treatment of adult patients with chronic, accelerated, or blast phase Ph+ CML with resistance, or intolerance to prior therapy. (aol.com)
- 1 DARZALEX FASPRO ® is the first and only FDA-approved treatment for patients with this blood cell disorder that is associated with the production of an abnormal protein, which leads to the deterioration of vital organs, most notably the heart, kidneys and liver. (biospace.com)
- DARZALEX FASPRO ® is not indicated and is not recommended for the treatment of patients with light chain (AL) amyloidosis who have NYHA Class IIIB or Class IV cardiac disease or Mayo Stage IIIB outside of controlled clinical trials. (biospace.com)
- The study evaluated DARZALEX FASPRO ® in combination with VCd, compared with VCd alone, a common treatment regimen used in adult patients with newly diagnosed AL amyloidosis. (biospace.com)
- Achieving hematologic complete response is an important treatment goal, and today's approval based on this clinical endpoint will provide doctors and the larger medical community with a new option to treat newly diagnosed patients. (biospace.com)
- RIDTs may be used to help with diagnostic and treatment decisions for patients in clinical settings, such as whether to prescribe antiviral medications. (cdc.gov)
- Therefore, antiviral treatment should not be withheld from patients with suspected influenza, even if they test negative. (cdc.gov)
- Based on data from several publications indicating that environmental factors play a major role in the development of AA 2 , the fact that the risk factors have not yet been well-described for our context, and because treatment is not widely available in developing countries, this study has been carried out since 2002, 14 with the purpose of providing more information for prevention of the disease. (haematologica.org)
- The evidence for many of these agents is anecdotal, and there is no general consensus regarding the best agent for treatment of steroid-resistant disease or cases refractory to steroid withdrawal. (medscape.com)
- The treatment options in use for COVID-19 at medical facilities include oxygen, corticosteroids, and IL6 receptor blockers for severely ill patients. (who.int)
- In terms revenue generation, among the applications, cancer outperformed other application types, owing to greater prevalence of the disease as well as higher efficacy of peptide therapeutics in cancer treatment. (medgadget.com)
- These AZA- and DCA-naive patients treated with AZA 100 mg/(m²·day) for 5 days to 7 days or DAC 20 mg/(m²·day) for 3 days to 4 days, or 20 mg/(m²·day) 1 day/week for 3 weeks/month were assessed for treatment responses and adverse events. (medscimonit.com)
- All the patients received a median of 2 treatment cycles. (medscimonit.com)
- Since the passage of the Orphan Drug Act in 1983, there has been significant acceleration in the number of pharmaceutical compounds identified, developed, and approved for the treatment of rare diseases, particularly within the past decade. (pharmacytimes.com)
- In one of the most well-known examples, the Tuskegee Syphilis Study conducted from 1932 to 1972, scientists deliberately withheld treatment from black men with syphilis in order to see how the disease progressed when left untreated. (nih.gov)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
- A new TB classification (Class B: Latent TB Infection Needing Evaluation for Treatment) should be used for all applicants who are recent arrivals to the United States (less than 5 years) from countries with a high TB prevalence, with a Mantoux TST reaction of 10 mm or greater of induration, and no evidence of TB disease. (cdc.gov)
Coronary artery2
- Myocardial Infarction Therapeutics Market - Increasing incidence of coronary artery disease and changes in lifestyle are the major factors expected to drive the growth of global myocardial infarction therapeutics market. (medgadget.com)
- Initially, the main issue was represented by heart failure and coronary artery disease, but a growing body of evidence has now shed light on the increased arrhythmic risk of this population, atrial fibrillation being the most frequently encountered. (bvsalud.org)
Manifestation of the disease1
- Labial swelling is most often a cosmetic complaint, but it can be a painful manifestation of the disease. (medscape.com)
Survival3
- 4 Although bone marrow transplants have increased the survival rate of patients with AA, most people do not have access to this therapy, and fatality rates of the disease remain high. (haematologica.org)
- Through patient-derived AML xenograft (PDX) models and single cell proteomics, we have elucidated the roles of E-sel in AML survival and drug resistance. (confex.com)
- Dr. Pierre Fenaux, of the University of Paris, presented the updated results from an international phase III trial (AZA-001) which was the first study to show an increased overall survival for higher-risk MDS patients. (eurekalert.org)
Splenic4
- [ 26 ] Bruns et al reported that low-dose splenic irradiation produced hematologic response and long-term relief of splenic pain in four of five patients with symptomatic congestive splenomegaly. (medscape.com)
- [ 12 ] Complications of splenic infarction were a frequent indication (60%) for operation in patients with septic emboli. (medscape.com)
- However, a patient with multiple splenic abscesses usually will require splenectomy. (medscape.com)
- This patient has a splenic abscess due to pneumococcal bacteremia. (medscape.com)
Thrombocytopenia5
- Importantly, the resultant thrombocytopenia in a patient with hypersplenism does not result in a proportional defect in hemostasis, as the total body platelet count largely remains unchanged but rather is redistributed. (medscape.com)
- In patients with heparin-induced thrombocytopenia (HIT), this antibody-antigen complex leads to platelet activation, removal of platelets from the circulation, and ultimately, thrombocytopenia. (clinicaladvisor.com)
- 2,8 Although circulating heparin-PF4 antibodies are often detected in individuals with heparin-induced skin necrosis, these patients rarely demonstrate profound thrombocytopenia or significant activation of the coagulation cascade, which is seen in classic HIT.2,7 It remains important to evaluate patients for these associations, however. (clinicaladvisor.com)
- Its first FDA-approved product, TAVALISSE® (fostamatinib disodium hexahydrate) tablets, is an oral spleen tyrosine kinase inhibitor for treating patients with chronic immune thrombocytopenia. (pennystocks.com)
- TAVALISSE® is also available in Europe (TAVLESSE) and Canada (TAVALISSE) for treating chronic immune thrombocytopenia in adult patients. (pennystocks.com)
Cardiac3
- Serious adverse reactions that occurred in at least 5 percent of patients in the D-VCd arm were pneumonia (9 percent), cardiac failure (8 percent) and sepsis (5 percent). (biospace.com)
- In this review, we provide an updated overview of the mechanisms triggering cardiac arrhythmias in cancer patients, their prevalence and management. (bvsalud.org)
- Other secondary objectives include identifying the benefits of VT-ART on cardiac function, as evaluated through an electrocardiogram, echocardiographic, biochemical variables, and on patient quality of life. (bvsalud.org)
Aplasia1
- After the second cycle, prolonged severe aplasia developed in the patient. (cdc.gov)
Chemotherapy3
- For low- and intermediate-risk patients, induction therapy should consist of ATRA and arsenic trioxide (ATO) without chemotherapy. (medscape.com)
- ATRA plus ATO with a certain amount of chemotherapy is a possible option, but ATO is not approved for use in high-risk patients. (medscape.com)
- Chemotherapy should be started whenever acid-fast bacilli are found in a specimen from a patient with HTLV-III/LAV infection and clinical evidence of mycobacterial disease. (cdc.gov)
Invasive5
- We report a lung-invasive fungal disease with possible cutaneous needle tract seeding in a patient with a febrile neutropenia caused by the Basidiomycetes mold Inonotus spp. (cdc.gov)
- Computed tomography of the lungs in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)
- Skin lesion at biopsy site 4 weeks after the biopsy in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)
- In most cases, specific, little invasive investigations allow diagnosing the disease and, hence, an appropriate therapy can be initiated. (thieme-connect.com)
- therefore, it can be easily performed in patients with contraindications to invasive ablation procedures. (bvsalud.org)
Splenomegaly4
- Splenectomy has a decreasing number of indications, but can still be used to help control or stage the underlying disease in cases of splenomegaly. (medscape.com)
- Splenectomy is occasionally indicated to help control or stage the underlying disease in cases of splenomegaly. (medscape.com)
- Inpatient care for patients with splenomegaly depends on the modality used to treat the underlying cause of the condition and on the complications of that care. (medscape.com)
- A wide variety of diseases are associated with splenomegaly, or enlargement of the spleen, with many of the mechanisms leading to this condition being exaggerated forms of normal spleen function. (medscape.com)
Cancer7
- Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
- Our commitment to the blood cancer community is driven and inspired by our mission to reimagine care so patients can redefine living. (jnj.com)
- Cancer patients want the expertise that Mayo Clinic can bring, but they also want humanity in their care. (mayoclinic.org)
- And we've come to appreciate that treating cancer is not about treating a disease. (mayoclinic.org)
- The NIH said that this funding opportunity is not open to research around cancer or communicable diseases, or projects focused on the empirical application of poorly characterized cells types for cell therapy. (genomeweb.com)
- Introduction: The results of a 2001-2005 polycythemia vera (PV) investigation in Eastern Pennsylvania revealed a disease cluster plus underreporting and false reporting to the Pennsylvania Cancer Registry (PCR). (cdc.gov)
- Leukemia is the most common malignant disease in infancy, corresponding approximately to 30% of cancer cases in children. (bvsalud.org)
Pipeline1
- Acceleron's innovative research has yielded an exciting late-stage candidate that complements and strengthens our growing cardiovascular portfolio and pipeline and holds the potential to build upon Merck's proud legacy in cardiovascular disease. (pharmiweb.com)
Inflammatory3
- Key role of mast cells and their major secretory products in inflammatory bowel disease. (thieme-connect.com)
- Erythema annulare centrifugum is a benign inflammatory skin disease that can occur at any age, without gender predilection. (cmaj.ca)
- Toquet et al investigated the phenotype of the lesional inflammatory cell infiltrate in patients with eosinophilic fasciitis and demonstrated a predominance of macrophages, CD8 + lymphocytes, and few eosinophils. (medscape.com)
Oncological1
- however, cardiovascular sequelae in this population augmented and now represent the second cause of death in oncological patients. (bvsalud.org)
Hospitalized COVID-191
- Something else that Rigel has worked on with regard to TAVALISSE® is the potential use for treating hospitalized COVID-19 patients. (pennystocks.com)
Consortium4
- Today's milestone is an important step for patients diagnosed with this rare disease," said Isabelle Lousada , Founder and CEO, Amyloidosis Research Consortium. (biospace.com)
- The two groups will not be collected by direct, prospective accrual to avoid randomization among the innovative and traditional arm: A retrospective selection through matched pair analysis will collect patients presenting features similar to the ones undergone VT-ART within the consortium (in each center independently). (bvsalud.org)
- Progressively, on a multicentric basis supervised by the promoting center in the VT-ART consortium, for each VT-ART patient enrollment, a matched pair patient profile according to the predefined features will be shared with the consortium to enroll a patient that has not undergone VT-ART. (bvsalud.org)
- Conclusion: Our trial will provide insight into the efficacy and safety of VT-ART through a matched pair analysis, via an observational, multicentric study of two groups of patients with or without VT-ART in the multicentric consortium (with subgroup stratification into dynamic cohorts). (bvsalud.org)
Kidney disease3
- But the patient-scientist collaborations at the core of two NIDDK-funded projects in kidney disease are proving that patients have a lot to bring to the table, when given the opportunity. (nih.gov)
- These variants are found in some people of African descent and are associated with an increased risk of kidney disease. (nih.gov)
- to identify the risk factors that lead patients infected by the new coronavirus to develop kidney disease. (bvsalud.org)
Radiographic findings1
- Definitions of chest radiographic findings that are suggestive of TB disease are provided to assist the civil surgeon in determining the proper TB classification. (cdc.gov)
Infections1
- 1 Pathophysiology is still uncertain and erythema annulare centrifugum has sometimes been associated with infections (particularly dermatophytic infections), foods, drugs, hematologic and endocrine diseases, and neoplasias. (cmaj.ca)
Chronic diseases1
- Rising prevalence of these chronic diseases across the world is further expected to widen the existing patient pool. (medgadget.com)
Prevalence2
- As there is no agreed-upon, worldwide threshold prevalence or incidence for what constitutes a rare disease, the definition often varies by country. (pharmacytimes.com)
- In the United States, if the total number of individuals affected by a disease or disorder is less than 200,000-which equates to a prevalence rate of approximately 6.4 cases per 10,000 citizens-then it is considered a rare disease. (pharmacytimes.com)
Adult1
- However, as the efficacy and safety of rational dosing regimens are lacking, we evaluated the effectiveness and safety of reduced-dose azacitidine (AZA) vs. decitabine (DAC) in adult MDS patients. (medscimonit.com)
Rare11
- CheckOrphan is a non-profit organization located in Basel, Switzerland and Santa Cruz, California that is dedicated to rare, orphan and neglected diseases. (checkorphan.org)
- Approximately 4,500 people in the U.S. develop this rare disease each year. (biospace.com)
- The development and implementation of a rare disease management program by healthcare providers and payors could greatly assist in improving the clinical, psycho-social and economic impacts for this patient population. (pharmacytimes.com)
- There are more than 7000 known rare diseases that affect a worldwide patient population that, if aggregated together, would be the third most populous country in the world. (pharmacytimes.com)
- But, within the past decade, the accelerated application and approval of drugs designated for orphan status to treat rare diseases in very limited numbers of patient have become increasing concerns for all stakeholders in the healthcare marketplace. (pharmacytimes.com)
- 1 By contrast, a disorder or disease is considered rare in the United Kingdom if it affects less than 50,000 individuals. (pharmacytimes.com)
- In the United States, it is estimated that 25 to 30 million people are afflicted with a rare disease, or approximately 8% to 10% of the population. (pharmacytimes.com)
- Worldwide, it is estimated that 350 million people suffer from a rare disease. (pharmacytimes.com)
- Rare diseases also account for 35% of all deaths during the first year of life, with children representing approximately 50% of patients with a rare disease. (pharmacytimes.com)
- However, a small number of these rare diseases (approximately 350) account for approximately 80% of the total number of patients affected. (pharmacytimes.com)
- and rheumatologic, 8% of rare diseases. (pharmacytimes.com)
Coronavirus1
- This new disease is not the first of its family, but a variation of the coronavirus family that rarely affects humans, being confined only to animals such as bats, cattle, cats, and camels, such as MERS-CoV and SARS-CoV. (bvsalud.org)
Gastrointestinal1
- 3 The disease can affect different organs in different people, but the most frequently affected organs are the heart, kidneys, liver, spleen, gastrointestinal tract and nervous system. (biospace.com)
Conditions1
- The mouth is frequently involved in conditions that affect the skin or other multiorgan diseases. (medscape.com)
Medicines1
- This agreement with Merck represents the culmination of decades of work by Acceleron researchers successfully leveraging our company's deep scientific expertise in the biology of the TGF-beta superfamily and driven by an unwavering dedication to delivering life-changing medicines for patients," said Habib Dable, chief executive officer and president, Acceleron. (pharmiweb.com)
Refractory1
- Multiple additional agents have been used in steroid-refractory disease. (medscape.com)
Regimen1
- Because it is difficult to distinguish tuberculosis from MAC disease by any criterion other than culture, and because of the individual and public health implications of tuberculosis, it is important to treat patients with a regimen effective against tuberculosis. (cdc.gov)
Abnormal1
- Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients. (thieme-connect.com)