Patients with familial hypercholesterolemia. Medical search. Frequent questions

Links to a video to help patients explain their FH diagnosis and organizations that provide patient supports. (genomebc.ca)
The diagnosis of both homozygous and heterozygous FH is based primarily on the finding of severe LDLc elevations in the absence of secondary causes of hypercholesterolemia. (medscape.com)
A probable diagnosis of heterozygous FH can be made if the LDLc level is greater than 330 mg/dL or if tendon xanthomas are present in a patient with an LDLc level above the 95th percentile. (medscape.com)
A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. (medscape.com)
Familial hypercholesterolemia: a challenge of diagnosis and therapy. (medscape.com)
Thirty-eight patients with a clinical diagnosis of definite or possible FH who had undergone DNA testing in the lipid clinic took part in semi-structured qualitative interviews. (ox.ac.uk)
He never dreamed he was on the verge of a heart attack, but knew something was wrong given persistent chest pain and a cholesterol reading of 420 mg/dl Dan struggled to get an accurate diagnosis for his condition, familial hypercholesterolemia (FH), from initially just being sent home and given antacids to fighting for a stress test that revealed he needed heart bypass surgery. (familyheart.org)
Prescribe JUXTAPID only to patients with a clinical or laboratory diagnosis consistent with HoFH. (drugs.com)
After a successful diagnosis of HoFH, patients are referred to a lipid specialist for advanced management of the condition. (delveinsight.com)
In addition to correctly classifying individuals into the two classes recognized in clinical studies for familial hypercholesterolaemia (with and without genetic diagnosis), a subset of patients with mixed characteristics was systematically identified as representing a third category. (medrxiv.org)
Like many FH patients, I had never heard of the disorder before my diagnosis. (familyheart.org)
Clinical diagnosis is based on a set of clinical criteria including lipid panel testing, personal and family history of hypercholesterolemia or premature ASCVD, presence of xanthomas on extensor tendons or thickening of the Achilles tendon, and early corneal arcus. (phekb.org)

Reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g. (globalrph.com)
Avery has a rare disorder known as Homozygous Familial Hypercholesterolemia - HoFH - that is causing early heart disease. (familyheart.org)
The safety and effectiveness of JUXTAPID have not been established in patients with hypercholesterolemia who do not have HoFH ( 1 ). (drugs.com)
JUXTAPID is a microsomal triglyceride transfer protein inhibitor indicated as an adjunct to a low-fat diet and other lipid-lowering treatments, including LDL apheresis where available, to reduce low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C) in patients with homozygous familial hypercholesterolemia (HoFH) ( 1 ). (drugs.com)
The safety and effectiveness of JUXTAPID have not been established in patients with hypercholesterolemia who do not have HoFH, including those with heterozygous familial hypercholesterolemia (HeFH) ( 1 ). (drugs.com)
Homozygous familial hypercholesterolemia (HoFH) is a rare form of familial hypercholesterolemia, an autosomal-dominant genetic disorder of lipid metabolism characterized by strikingly elevated levels of low-density lipoprotein cholesterol (LDL-C). (delveinsight.com)
HeFH patients can have cholesterol levels in the 350-550 mg/dL range, while HoFH can be in the 650-1,000 mg/dL range. (delveinsight.com)
What is Homozygous Familial Hypercholesterolemia (HoFH)? (delveinsight.com)
According to the National Institutes of Health (NIH) , patients with HoFH have LDL-C levels three to six times higher than normal . (delveinsight.com)
Nevertheless, the American Heart Association (AHA) has addressed this challenge by encouraging the screening for elevated levels of lipoprotein(a) (Lp[a]), which is highly prevalent among patients with HoFH. (delveinsight.com)
The European Atherosclerosis Society (EAS) recommends promptly referring patients with suspected HoFH to specialist centers for a comprehensive ACVD evaluation and clinical management. (delveinsight.com)

Familial Hypercholesterolemia results from mutations in the LDL receptor, ApoB, PCSK9, and ApoE genes. (hindawi.com)
Patients receiving proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors 6. (nih.gov)
Progenika added that its CLIA-certified US laboratory has provided genotyping services in clinical trials for anti-PCSK9 drugs for familial hypercholesterolemia. (genomeweb.com)
Background: The HAUSER-RCT study showed that 24 weeks of evolocumab (a proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitor) in paediatric patients with heterozygous familial hypercholesterolaemia was safe and improved lipid parameters compared to placebo. (amsterdamumc.org)
The expanded definition could also mean more patients will be eligible to receive expensive cholesterol-lowering drugs, including the new PCSK9 inhibitor drugs, (Repatha from Amgen and Praluent from Sanofi/Regeneron). (cardiobrief.org)
Sanofi and Regeneron's Praluent (alirocumab) and Amgen's Repatha (evolocumab) are PCSK9 inhibitors approved last summer for the treatment of high cholesterol among patients with heterozygous familial hypercholesterolemia or patients with clinical atherosclerotic cardiovascular disease who require additional lowering of low-density lipoprotein (bad) cholesterol. (pharmacytimes.com)
May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects? (cdc.gov)

People with familial hypercholesterolemia have elevated levels of low-density lipoprotein (LDL) cholesterol - the so-called bad kind of cholesterol that builds up in blood vessels and can lead to blood clots and heart attacks - from the time they're born. (everydayhealth.com)
Many people with familial hypercholesterolemia have no obvious symptoms early in life, especially if they have the milder, more common form of the condition that's inherited from only one parent. (everydayhealth.com)
Most people with familial hypercholesterolemia also have a family history of heart disease or heart attacks early in life. (everydayhealth.com)
Some, but not all, people with familial hypercholesterolemia also have some telltale physical signs of the condition that develop as a result of extra cholesterol accumulating in different parts of the body. (everydayhealth.com)

Paediatric patients aged 10-17 years with heterozygous familial hypercholesterolaemia who completed 24 weeks of monthly treatment with subcutaneously administered placebo or 420 mg evolocumab in HAUSER-RCT with no serious treatment-emergent adverse events were eligible to enrol in HAUSER-OLE. (amsterdamumc.org)
Interpretation: After 80 weeks of treatment, evolocumab was safe, well tolerated, and led to sustained reductions in LDL cholesterol in paediatric patients with heterozygous familial hypercholesterolaemia. (amsterdamumc.org)
Heterozygous familial hypercholesterolaemia (FH) is a common autosomal dominant disorder. (nih.gov)
Outcome of case finding among relatives of patients with known heterozygous familial hypercholesterolaemia. (legehandboka.no)

Background Many patients with heterozygous familial hypercholesterolemia (HeFH) fail to reach optimal low-density lipoprotein cholesterol (LDL-C) levels with available lipid-lowering medications, including statins, and require treatment using alternative methods such as lipoprotein apheresis. (elsevierpure.com)
Objective To evaluate the efficacy of alirocumab 150 mg every 2 weeks (Q2W) compared with placebo in reducing the frequency of lipoprotein apheresis treatments in patients with HeFH. (elsevierpure.com)
Discussion The ODYSSEY ESCAPE trial will determine whether alirocumab reduces the frequency of lipoprotein apheresis in patients with HeFH. (elsevierpure.com)
While most people suffer from HeFH, in rare cases, the mutations in both copies of genes related to cholesterol metabolism give rise to the lethal form of familial hypercholesterolemia, i.e. (delveinsight.com)

A major difference between homozygous and heterozygous familial hypercholesterolemia is the presence of cholesterol levels. (delveinsight.com)

There are five types of familial dyslipidemia (not including subtypes), and each are classified from both the altered lipid profile and by the genetic abnormality. (wikipedia.org)
Studies with other lipid lowering therapies have only reached LDL-C levels of less than 2.5 mmol/L ( 97 mg/dL ) in around 20% of patients. (metabolismnews.net)
The objective of our study was describing the prevalence and prognosis of FH, assessed by Dutch Lipid Clinic Network (DLCN) criteria, in patients with ACS. (fortunejournals.com)
Younger patients had a more atherogenic lipid profile than the older subgroup with CAD. (hindawi.com)
A National Heart, Lung and Blood Institute expert panel recommends universal lipid screening for patients who are between 9 and 11 years of age and a second universal screening performed between 17 and 21 years of age. (cdc.gov)
To analyze, if circulating monocytes already show increased lipid content and differences in lipoprotein metabolism, we compared monocytes from patients with Familial Hypercholesterolemia (FH) with those from healthy individuals. (biomedcentral.com)
Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. (globalrph.com)
All patients were positive about DNA screening being undertaken by familiar and trusted clinicians within the lipid clinic. (ox.ac.uk)
Most patients had already cascaded close relatives for serum cholesterol testing following their attendance at the lipid clinic. (ox.ac.uk)
When lipid goals cannot be achieved with conventional treatments, evolocumab is an effective add-on therapy in paediatric patients. (amsterdamumc.org)
Often, doctors can diagnose familial hypercholesterolemia based on your family history of the condition and a blood test known as a lipid panel that measures levels of fatty substances called triglycerides , LDL cholesterol, and high-density lipoprotein (HDL) cholesterol - the "good" cholesterol that helps purge blood vessels of debris and reduce levels of triglycerides that make blood thicker, stickier, and more likely to clot. (everydayhealth.com)
Leading experts in lipid management, Familial Hypercholesterolemia and genetic counselling are involved in the development and delivery of this course. (northumbria.ac.uk)
Direct and Indirect Effects of SARS-CoV-2 Pandemic in Subjects with Familial Hypercholesterolemia: A Single Lipid-Center Real-World Evaluation. (cdc.gov)

Genetic identification of familial hypercholesterolemia within a single U.S. health care system. (nature.com)

Participants who expressed a preference said they favoured indirect (patient-mediated) methods of cascading as they considered indirect approaches to be less threatening to family members than direct clinical contact. (ox.ac.uk)
Efficacy and Safety of Alirocumab in High-Risk Patients With Clinical Atherosclerotic Cardiovascular Disease and/or Heterozygous Familial Hypercholesterolemia (from 5 Placebo-Controlled ODYSSEY Trials). (uchicago.edu)
Data were analysed for 2,975,281 patients with total or LDL-cholesterol measurement from 1 Jan 1999 to 31 August 2013 using the Clinical Practice Research Datalink (CPRD). (nih.gov)
Biallelic mutations are detectable in the vast majority of patients with clinical features and biochemistry that are consistent with CTX. (medscape.com)
2014] would improve clinical outcomes in patients with ARDS. (druglib.com)
The laboratory is engaged in clinical investigation related to PAD, including epidemiology of symptomatic PAD, the genetic bases of PAD and alterations in arterial function in patients with PAD. (mayo.edu)
[ 4 ] In 1971, Salen found that chenodeoxycholic acid (CDCA), an important bile acid, was virtually absent in patients with clinical symptoms of the disease. (medscape.com)

Familial hypercholesterolemia (FH) is a relatively common Mendelian genetic disorder that is associated with elevated plasma low-density lipoprotein cholesterol (LDL-C) levels and dramatically increased lifetime risk for premature atherosclerotic cardiovascular disease (ASCVD). (phekb.org)
COVID-19 associated risks of myocardial infarction in persons with familial hypercholesterolemia with or without ASCVD. (cdc.gov)

Méthodologie: Entre septembre 2021 et février 2022, des écouvillonnages oropharyngés et/ou nasopharyngés de travailleurs symptomatiques COVID-19 et apparemment en bonne santé sélectionnés consécutivement du site minier de Wahgnion dans le sud-ouest du Burkina Faso qui ont consenti à l'étude ont été prélevés selon les deux programme de quart de semaines et testé pour le SRAS-CoV-2 à l'aide d'un test RT-PCR. (bvsalud.org)

Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. (medscape.com)
Patient meetings, FH Awareness Day/Week Sept. 2019, 3rd Symposium for Familial Hypercholesterolemia on 12.11.2019, a joint project of FHchol Austria and the Austrian Atherosclerosis Society, Travel expenses for various congress visits in connection with familial hypercholesterolemia, e.g. (amgen.com)

Familial hypercholesterolemia is what's known as an autosomal dominant genetic condition. (everydayhealth.com)

Alirocumab ( Praluent ) lowers cholesterol in patients with heterozygous familial hypercholesterolemia to levels unreachable with statins alone, according to results from four ODYSSEY trials. (metabolismnews.net)
The results have shown that adding Alirocumab to statins in patients with heterozygous familial hypercholesterolemia rapidly lowers LDL-C to unprecedented levels that are unreachable with statins alone, and that these reductions are maintained in the long term. (metabolismnews.net)
Adding Alirocumab to statins may be an important treatment strategy for patients not able to reach their LDL-C goals with statins alone. (metabolismnews.net)
also, had been diagnosed more often of hypercholesterolemia and had higher LDLc and statins treatments before admission. (fortunejournals.com)
A total of 1,456 patients presenting within 7 days of a spontaneous lobar ICH while taking statins will be randomized to one of two treatment strategies: discontinuation vs. continuation of statin therapy (using the same agent and dose that they were using at ICH onset). (nih.gov)
All patients received open-label subcutaneous evolocumab 420 mg monthly with background statins with or without ezetimibe for 80 additional weeks. (amsterdamumc.org)
Because the benefits of statins may include prevention of serious or potentially fatal events in a small group of very high-risk pregnant patients, contraindicating these drugs in all pregnant women is not appropriate. (medlineplus.gov)
Patients taking statins should notify their health care professionals if they become pregnant or suspect they are pregnant. (medlineplus.gov)
Patients who are at high risk of heart attack or stroke who require statins after giving birth should not breastfeed and should use alternatives such as infant formula. (medlineplus.gov)
Discuss with patients whether they may discontinue statins temporarily while breastfeeding. (medlineplus.gov)
The FDA hopes the revised language in the prescribing information will help reassure health care professionals that statins are safe to prescribe in patients who can become pregnant, and help them reassure patients with unintended statin exposure in early pregnancy or before pregnancy is recognized that the medicine is unlikely to harm the unborn baby. (medlineplus.gov)
Statins have been shown to decrease depressive symptoms in certain groups of patients, an effect that is mostly attributed to their anti-inflammatory and neurotransmitter modulatory potentials. (druglib.com)
Familial hypercholesterolemia and statins in the COVID-19 era: Mitigating the risk of ischemic stroke. (cdc.gov)
[ 1 ] Physical activity also reduces cardiovascular risk, and the combination of statins and high level of physical fitness reduces cardiovascular mortality in patients with hyperlipidemia patients more than either treatment alone. (medscape.com)

Sudden Cardiac Death Caused by a Fatal Association of Hypertrophic Cardiomyopathy (MYH7, p.Arg719Trp), Heterozygous Familial Hypercholesterolemia (LDLR, p.Gly343Lys) and SARS-CoV-2 B.1.1.7 Infection. (cdc.gov)

Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. (medscape.com)
Familial Hypercholesterolemia Screening in Children and Adolescents in the United States: Where Are We Heading? (cdc.gov)

However, one parent will have severe hypercholesterolemia and will also probably have either a personal or family history for premature coronary artery disease (CAD). (medscape.com)
Familial hypercholesterolemia and coronary heart disease: a HuGE association review. (medscape.com)
Familiar hypercholesterolemia (FH) is genetic disease that leads to increased serum low-density lipoprotein cholesterol (LDLc) and premature acute coronary syndromes (ACS). (fortunejournals.com)
In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR® can be started simultaneously with diet. (globalrph.com)
Diabetic patients with history of myocardial infarction or coronary revascularization 4. (nih.gov)
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
Blood group non-O is not associated with long-term adverse outcomes in patients undergoing percutaneous coronary intervention. (nih.gov)
Neurotensin and Adverse Cardiovascular Outcomes in Patients Undergoing Percutaneous Coronary Intervention. (nih.gov)

Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. (medscape.com)

FH is classified as a type 2 familial dyslipidemia. (wikipedia.org)
Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (globalrph.com)

Reduce elevated TG in patients with hypertriglyceridemia (Fredrickson type lV hyperlipidemia). (globalrph.com)
Reduce elevated TG and VLDL-C in patients with primary dysbetalipoproteinemia (Fredrickson type lll hyperlipidemia). (globalrph.com)
For example, in familial combined hyperlipidemia, expression may occur only in the presence of significant secondary causes. (msdmanuals.com)

Screening for Familial Hypercholesterolemia in Children: What Can We Learn From Adult Screening Programs? (cdc.gov)
Patients' experiences and views of cascade screening for familial hypercholesterolemia (FH): a qualitative study. (ox.ac.uk)
Familial DNA cascade screening for familial hypercholesterolemia (FH) has recently been introduced in Scotland. (ox.ac.uk)
This study investigated index patients' experiences of DNA testing and mediating cascade screening. (ox.ac.uk)
We conclude that DNA screening and indirect familial cascading is perceived as highly acceptable to index patients with FH. (ox.ac.uk)
There is, therefore, a need for further systematic research to investigate patients', family members' and staff views of the acceptability of direct versus indirect methods of cascade screening. (ox.ac.uk)
We conducted a prospective survey study of unselected University of Washington Medicine patients enrolled in a genetic research study screening for pathogenic variation in medically important genes. (nature.com)

According to 2021 research , familial hypercholesterolemia is an inherited form of hypercholesterolemia where most individuals have high levels of cholesterol at birth. (healthline.com)

This analysis in more than 1250 patients showed that Alirocumab rapidly lowered low density lipoprotein cholesterol ( LDL-C ) to unprecedented levels and the reductions were maintained long term. (metabolismnews.net)
In addition, patients who initially received Alirocumab 75 mg had their dose adjusted to 150 mg at week 12 if they did not achieve their pre-specified LDL cholesterol goal by week eight. (metabolismnews.net)
Treatment-emergent adverse events occurred in a similar proportion of patients on Alirocumab ( 80.5% ) and placebo ( 83% ) leading to study discontinuation in 3.9% and 3.6% patients, respectively. (metabolismnews.net)
Despite high baseline levels, Alirocumab has reduced LDL cholesterol concentrations to less than 1.8 mmol/L ( 70 mg/dL ) at week 24 in 63% of patients in FH I and II and in 56% of patients in the pool of HIGH FH and LONG TERM patients. (metabolismnews.net)
Patients will be randomly assigned (2:1, respectively) to receive alirocumab 150 mg subcutaneously Q2W or placebo subcutaneously Q2W (both in 1-mL injections) for 18 weeks. (elsevierpure.com)

Health care professionals should discontinue statin therapy in most pregnant patients, or they can consider the ongoing therapeutic needs of the individual patient, particularly those at very high risk for cardiovascular events during pregnancy. (medlineplus.gov)
The Knowns and Unknowns of Contemporary Statin Therapy for Familial Hypercholesterolemia. (cdc.gov)

Patients who have recurrent atherosclerotic events in spite of optimal treatment-a case has been made to check those patients. (medscape.com)

In 2020, Representatives of the Global Familial Hypercholesterolemia Community published JAMA Cardiology Global Call to Action with public policy recommendations. (cdc.gov)

Familial Hypercholesterolemia (FH) is a genetic condition that results in elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth, resulting in increased risk of heart disease and myocardial infarction. (cdc.gov)

ABSTRACT Earlier reports on the detection of Helicobacter DNA in the gallbladder tissue of patients with biliary diseases have shown discordant results. (who.int)

David is a 63-year-old man with a 20-year history of hypercholesterolemia and 5-year history of prediabetes. (wiley.com)

There's also a genetic condition called familial hypercholesterolemia that affects about 1 in every 311 people. (medlineplus.gov)

Two or more other CVD risk factors are present in the adolescent patient. (globalrph.com)
The guideline emphasizes patient-physician shared decisions with a multidisciplinary team-based approach to the implementation of recommended preventive strategies with sensitivities to the social determinants of health that may include specific barriers to care, limited health literacy, financial distress, cultural influences, education level, and other socioeconomic risk factors related to short- and long-term health goals. (acc.org)
In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)

Familial hypercholesterolemia is an inherited type of high cholesterol that has nothing to do with eating too many burgers and fries. (everydayhealth.com)
This guideline covers identifying and managing familial hypercholesterolaemia (FH), a specific type of high cholesterol that runs in the family, in children, young people and adults. (bvsalud.org)

Advise patients to promptly report to their physician unexplained and/or persistent muscle pain, tenderness, or weakness and discontinue rosuvastatin tablets if signs or symptoms appear. (nih.gov)

Dr. Kullo's laboratory is engaged in several projects related to FH, including the use of electronic phenotyping for rapid ascertainment of FH from electronic health records (EHRs), use of EHR-based strategies to improve outcomes in patients with FH, assigning pathogenicity to variants identified from sequencing of FH-related genes and investigating the pleiotropic effects of FH-related genes. (mayo.edu)

What genes are involved in familial hypercholesterolaemia (FH)? (patient.info)
Using microarray analysis we found in FH patients a significant up-regulation of 1,617 genes and a down-regulation of 701 genes compared to monocytes from healthy individuals. (biomedcentral.com)

The prevalence of possible or probable FH increased up to 21% in patients with premature ACS. (fortunejournals.com)
15.8% of patients with ACS have possible/probable FH and the prevalence increases up to 24% in patients with premature ACS. (fortunejournals.com)

Familial hypercholesterolaemia (FH) is a highly prevalent silent disease with known genetic causes and poor prognosis if undiagnosed into adulthood. (medrxiv.org)

Why continued lipoprotein apheresis is vital for homozygous familial hypercholesterolemia patients with COVID-19. (cdc.gov)

LDL receptor analysis can be used to identify the specific LDL receptor defect, and LDL receptor or apoB-100 studies can help distinguish heterozygous FH from the similar syndrome of familial defective apoB-100. (medscape.com)

NEW YORK (GenomeWeb) - Grifols subsidiary Progenika Biopharma today announced it has received the CE mark for its Seqpro Lipo IS next-generation sequencing-based diagnostic assay for familial hypercholesterolemia. (genomeweb.com)
proposed that H. pylori All patients received diagnostic upper to the QIAamp spin column in a 2 present in human bile samples might rep- gastrointestinal endoscopy and gastric mL collection tube were processed ac- resent a risk factor for gallstone formation biopsies were taken to confirm the cording to Qiagen protocol. (who.int)
Le test de réaction en chaîne par polymérase en temps réel (RT-PCR) est la méthode de confirmation recommandée pour le diagnostic de l'infection par le SRAS-CoV-2. (bvsalud.org)

It has been demonstrated that the number of circulating hEPC is decreased in individuals with hypercholesterolemia, hypertension, and/or diabetes. (intechopen.com)

Mackenzie has a genetic disorder, familial hypercholesterolemia (FH), and is at great risk for early, aggressive heart disease. (familyheart.org)

Dietary treatment of familial hypercholesterolemia. (medscape.com)
Approximately 8500 patients in the United States are candidates for treatment with Orkambi. (pharmacytimes.com)
Alecensa is an oral TKI approved for the second-line treatment of patients with anaplastic lymphoma kinase (ALK) positive NSCLC. (pharmacytimes.com)
Familial hypercholesterolaemia and COVID-19: A two-hit scenario for endothelial dysfunction amenable to treatment. (cdc.gov)
[ 2 ] However, 7% to 29% of patients are reported to develop muscle complaints while receiving statin treatment, [ 3 ] and these complaints may be exacerbated by exercise. (medscape.com)
[ 12 ] STOMP researchers found that more patients in the atorvastatin group than in the placebo group developed muscle complaints, but there were no differences in muscle strength and endurance, aerobic performance, or physical activity levels after 6 months of treatment. (medscape.com)

The module will introduce you to the pathophysiology of the disease and the subsequent impact for the patient and family. (northumbria.ac.uk)

Adult patients had similar levels of these analytes regardless of outcome. (cdc.gov)
In addition to the samples from the 55 pediatric patients, people less than 21 years of age, who had laboratory-confirmed Ebola virus disease, we selected samples from 50 adult patients, more than 21 years of age, who had laboratory-confirmed infection. (cdc.gov)
A total of 45 of the 55 pediatric patients and 49 of the 50 selected adult patients had sufficient serum available for the proposed studies. (cdc.gov)
We found that a higher percentage of pediatric than adult patients exhibited hemorrhage, but overall case-fatality rates remained lower for children than for adults. (cdc.gov)
Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic. (cdc.gov)

A 2017 study showed T1/FLAIR hypointensity consistent with cerebellar vacuolation and T1/FLAIR/SW hypointense alterations compatible with calcification in a subgroup of patients with CTX. (medscape.com)

The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation, according to a study in the March 10 issue of JAMA. (news-medical.net)
Individuals who inherit a copy of the gene mutation that causes familial hypercholesterolemia from just one parent have a milder form of the condition known as heterozygous familial hypercholesterolemia. (everydayhealth.com)
Approximately 13% of patients with DMD have an exon 51 gene mutation. (pharmacytimes.com)

the prevalence of possible FH was 14.5%, probable-FH 1.1% and only 1 patient had definite-FH. (fortunejournals.com)
More than 300 patients have been diagnosed worldwide, with an estimated prevalence of 1 case per 50,000 individuals in white populations. (medscape.com)

A simple blood test can be used to predict which chronic hepatitis C patients will respond to interferon-based therapy, according to a report in the May issue of Cellular and Molecular Gastroenterology and Hepatology, the basic science journal of the American Gastroenterological Association. (news-medical.net)
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial. (druglib.com)
We aimed to investigate the antidepressant effects of simvastatin as an adjuvant therapy in patients with moderate to severe depression. (druglib.com)
Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (druglib.com)

Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein cholesterol (LDL cholesterol), in the blood and early cardiovascular diseases. (wikipedia.org)
Heterozygous familial hypercholesterolemia is an inherited disease associated with very high levels of LDL cholesterol ( LDL-C ) that can put patients at risk for cardiovascular disease. (metabolismnews.net)
The average LDL cholesterol level at baseline was 3.7 mmol/L ( 141.2 mg/dL ) in the pool of FH I and FH II patients and 4.3 mmol/L ( 166.1 mg/dL ) in the pool of HIGH FH and LONG TERM patients with heterozygous familial hypercholesterolemia. (metabolismnews.net)
Familial hypercholesterolaemia is inherited high cholesterol. (patient.info)
Hypercholesterolaemia means cholesterol levels in your blood are too high. (patient.info)
How is familial hypercholesterolemia different than nonheriditary high cholesterol? (healthline.com)
Michelle had high cholesterol her entire life, but didn't know it was familial hypercholesterolemia (FH) and passed down from her dad. (familyheart.org)
Familial Hypercholesterolemia (FH) is a common genetic disorder that causes extremely high LDL Cholesterol from birth. (familyheart.org)
These high LDL levels, if untreated, can cause aggressive narrowing and blocking of the blood vessels even before birth, which progresses rapidly, triggering serious cardiac issues for patients much earlier in life than the general population. (delveinsight.com)
FDA expects removing the contraindication will enable health care professionals and patients to make individual decisions about benefit and risk, especially for those at very high risk of heart attack or stroke. (medlineplus.gov)
According to the official guidelines, cholesterol should be lowered as much as possible: in particular in high-risk individuals and those with inherited high cholesterol (FH: familial hypercholesterolemia). (ravnskov.nu)
Improvement of outcome prediction of hospitalized patients with COVID-19 by a dual marker strategy using high-sensitive cardiac troponin I and copeptin. (nih.gov)
Mutation analysis internationally reveals the following high frequency alleles: T339M in Dutch patients, R474(Q-W) in Japanese patients, and A216P in Italian patients. (medscape.com)

Most patients with homozygous FH do not survive adulthood beyond age 30 years unless treated with unusual methods, such as liver transplantation, LDL apheresis, or ileal bypass surgery to dramatically lower their LDLc levels. (medscape.com)

Illingworth DR. Management of hypercholesterolemia. (medscape.com)
This activity is intended for lipidologists, cardiologists, and other healthcare professionals involved in the management of patients with familial hypercholesterolemia (FH). (medlearninggroup.com)
Serum samples were obtained as part of the management of these patients and were stored in liquid nitrogen. (cdc.gov)
Collateral damage of the COVID-19 pandemic on the management of homozygous familial hypercholesterolemia. (cdc.gov)
Negative impact of COVID-19 pandemic on the lifestyle and management of patients with homozygous familial hypercholesterolemia. (cdc.gov)

We have begun to research how to prevent heart disease in patients under 40, which may reduce complications from heart disease in later adulthood. (medlineplus.gov)

Hypercholesterolemia is the most common and treatable cause of heart disease. (hindawi.com)

These changes include removing the contraindication against using these medicines in all pregnant patients. (medlineplus.gov)

Sensitivity analysis demonstrated no significant drop in discrimination (AUC 0.858, 95% CI 0.845-0.869) after excluding secondary causes of hypercholesterolaemia. (nih.gov)

Anatomy13

Organisms1

Diseases18

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes22

Technology, Industry, Agriculture4

Information Science3

Health Care12

Geographicals5

Diagnosis12

HoFH11

PCSK97

People with familial hypercholesterolemia4

Heterozygous familial hypercholesterolaemia4

HeFH4

Homozygous and heterozygous1

Lipid13

Identification of familial1

Clinical7

ASCVD2

20221

Atherosclerosis2

Autosomal dominant genetic1

Statins14

LDLR1

Children and adolescents2

Coronary8

Mutations1

Dyslipidemia2

Hyperlipidemia3

Screening7

20211

Alirocumab5

Statin therapy2

Atherosclerotic1

Cardiology1

Myocardial infarction1

Abstract1

Prediabetes1

Genetic condition1

Risk factors3

Type of high cholesterol2

Symptoms1

Ascertainment1

Genes2

Premature2

Highly prevalent1

Lipoprotein apheresis1

ApoB1

Diagnostic3

Hypertension1

Mackenzie1

Treatment6

Pathophysiology1

Adult5

Alterations1

Gene mutation3

Prevalence2

Therapy5

High13

Apheresis1

Management5

Adulthood1

Heart disease1

Medicines1

Secondary causes1