Patients with combination. Medical search. Frequent questions

Further, the U.S. Food and Drug Administration has not approved any immunosuppressive drugs or drug regimens specifically for use in patients with a lung transplant. (sciencedaily.com)
As of the data cut-off of January 20, 2023, 71 patients were treated across 9 dose levels evaluating different dosing regimens. (businesswire.com)
The combination treatments demonstrated encouraging activity in heavily pre-treated patients (median of 3 prior systemic regimens). (biospace.com)
Improving the convenience of leukemia therapy with oral and primarily outpatient treatment regimens are also particularly valuable to enhance patient satisfaction. (lls.org)
Despite the benefits of ICS-containing regimens in COPD management, healthcare providers should remain vigilant regarding the possible development of pneumonia as a complication in COPD patients receiving such therapies. (ersjournals.com)
The cluster model was further applied to 283 patients who received conventional regimens consisting of corticosteroids with or without a single immunosuppressive agent (dual-combo therapy or monotherapy). (frontiersin.org)
We are excited to share these new findings, which show promising results for pembrolizumab-based treatment regimens for patients with advanced NSCLC," said senior author Roy Herbst, deputy director of Yale Cancer Center and assistant dean for translational research at Yale School of Medicine. (worldpharmanews.com)
We are very pleased with how the treatment regimens helped improve survival outcomes for patients. (worldpharmanews.com)
This is a Phase 1b/2, open-label, dose escalation study to evaluate the safety, tolerability, PK, and immunogenicity of ADG126-pembrolizumab combination regimens in patients with advanced/metastatic solid tumors. (fredhutch.org)
At the end of 48 weeks, at least 75 percent of patients in each of the three groups had viral load measurements of less than 400 copies/mL in these abacavir/lamuvidine containing regimens. (dukehealth.org)
RESULTS: Most patients were at least 80% compliant with interferon alpha-2b/ribavirin or peginterferon alpha-2b/ribavirin therapy and had SVR rates of 52% and 63%, respectively, for the 2 regimens. (duke.edu)
AstraZeneca Oncology R&D executive vice-president José Baselga said: "Clinical benefit was observed in a trial population that included a high proportion of patients with squamous disease and multiple choices of chemotherapy regimens. (clinicaltrialsarena.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

SSE: 688235), and SpringWorks Therapeutics, Inc. (NASDAQ: SWTX), today announced that they will present updated clinical data from the Phase 1b trial of BeiGene's RAF dimer inhibitor, lifirafenib, in combination with SpringWorks' MEK inhibitor, mirdametinib, in patients with advanced or refractory solid tumors with RAS mutations, RAF mutations and other MAPK pathway aberrations. (businesswire.com)
The lifirafenib plus mirdametinib combination represents a novel targeted approach to treat solid tumors driven by RAS/RAF mutations, and other MAPK pathway aberrations. (businesswire.com)
This ongoing Phase 1b trial ( NCT03905148 ) is an open-label, dose escalation and expansion study to investigate the safety, pharmacokinetics (PK) and antitumor activities of mirdametinib in combination with lifirafenib, BeiGene's RAF dimer inhibitor, in patients with advanced or refractory solid tumors harboring RAS mutations, RAF mutations, and other MAPK pathway aberrations. (businesswire.com)
This study will test how safe and effective the experimental drug NUV-868 is by itself and in combination with a PARP inhibitor in people with advanced solid tumors. (facingourrisk.org)
This study will initially treat up to approximately 300 patients with advanced solid tumors at approximately 30 sites, worldwide. (astrazenecaclinicaltrials.com)

The performance of the clustering was generally replicated in patients who received initial dual-combo therapy or monotherapy. (frontiersin.org)
We successfully developed a cluster model that stratified patients with myositis-associated ILD who were treated with initial triple-combo therapy into subgroups with different prognoses, although this model failed to identify a patient subgroup that showed survival benefits from triple-combo therapy over dual-combo therapy or monotherapy. (frontiersin.org)
In addition, magaldrate/domperidone combination improved in a statistically manner the quality of life of patients with gastroesophageal reflux respect to monotherapy , and more patients perceived the combination as a better treatment. (scirp.org)
Novartis has announced data from the Phase III COMBI-d study showing a significant survival benefit for patients with BRAF V600E/K mutation-positive metastatic melanoma when treated with the combination of Tafinlar® (dabrafenib) and Mekinist® (trametinib) compared to Tafinlar monotherapy alone. (worldpharmanews.com)
This final analysis from COMBI-d confirms prior results showing a statistically significant improvement in overall survival among patients with BRAF V600E/K mutation-positive metastatic melanoma receiving the combination of dabrafenib and trametinib compared to dabrafenib monotherapy," said Georgina Long, B.Sc. (worldpharmanews.com)
The final analysis included the 423 patients enrolled in COMBI-d and showed that the combination of Tafinlar and Mekinist achieved a statistically significant overall survival (OS) benefit compared to Tafinlar monotherapy (median of 25.1 months vs 18.7 months)[1]. (worldpharmanews.com)
The safety profile of the combination was consistent with that observed with each drug as a monotherapy. (itbusinessnet.com)
AstraZeneca's drug is also undergoing a separate Phase III trial, PEARL, as monotherapy in stage IV NSCLC patients. (clinicaltrialsarena.com)

In a study publishing Oct. 31, 2023 in The Lancet Oncology , UC San Francisco researchers conducted a phase 1 clinical trial to determine whether a single priming dose of radioligand therapy 177 Lu-PSMA-617 combined with pembrolizumab immunotherapy - an immunotherapy drug, or immune checkpoint inhibitor - would have a beneficial effect in treating patients with mCPRC. (ucsf.edu)
At the seven-year descriptive OS analysis, 67% of LYNPARZA patients were alive versus 47% of placebo patients (44% of whom had a subsequent PARP inhibitor), and 45% of LYNPARZA patients versus 21% of placebo patients were alive and had not received a first subsequent treatment. (merck.com)
Participants with triple-negative breast cancer will receive either NUV-868 alone or in combination with the oral PARP inhibitor olaparib. (facingourrisk.org)
The oral BCL-2 inhibitor venetoclax in combination with a hypomethylating agent (i.e. azacitidine or decitabine) has recently become a paradigm-shifting new standard of care for older patients with AML who are ineligible for intensive chemotherapy. (lls.org)
Conclusions Combinations of statins, aspirins, and β blockers improve survival in high risk patients with cardiovascular disease, although the addition of an angiotensin converting enzyme inhibitor conferred no additional benefit despite the analysis being adjusted for congestive cardiac failure. (bmj.com)
These data represent the first assessment of daratumumab in combination with a next generation proteasome inhibitor (PI) and an immunomodulatory agent earlier in the treatment paradigm for multiple myeloma. (jnj.com)
NEW YORK, November 13, 2023 - Pfizer Inc. (NYSE: PFE) announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive opinion for TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI® (enzalutamide), for the treatment of adult patients with metastatic castration-resistant prostate cancer (mCRPC) in whom chemotherapy is not clinically indicated. (pfizer.com)
To stratify patients with polymyositis/dermatomyositis-associated interstitial lung disease (ILD) who were initially treated with an intensive regimen consisting of high-dose corticosteroids, a calcineurin inhibitor, and intravenous cyclophosphamide (triple-combo therapy) into subgroups based on mortality outcomes by a cluster analysis using a large-scale multicenter retrospective cohort of Japanese patients with myositis-associated ILD (JAMI). (frontiersin.org)
COMBI-d is a pivotal Phase III randomized, double-blinded study (NCT01584648) comparing the combination of the BRAF inhibitor, Tafinlar, and the MEK inhibitor, Mekinist, to single agent therapy with Tafinlar and placebo in patients with unresectable (Stage IIIC) or metastatic (Stage IV) BRAF V600E/K mutation-positive cutaneous melanoma. (worldpharmanews.com)
Poor reduction of HIV-1 RNA titres in nucleoside reverse transcriptase inhibitor experienced patients treated with indinavir combination therapy. (bmj.com)
METHODS: Samples of semen and blood were obtained from a cohort of 12 nucleoside reverse transcriptase inhibitor experienced men before and during 25-68 weeks of combination therapy, which included the protease inhibitor indinavir. (bmj.com)
Methods This non-randomized, multicohort, phase II study evaluated the efficacy and safety of the anti-PD-1 antibody nivolumab 240 mg administered every 2 weeks in combination with the CDK4/6 inhibitor abemaciclib 150 mg twice daily and either fulvestrant (FUL) or letrozole (LET) as a first-line or second-line treatment for HR-positive HER2-negative metastatic breast cancer. (bmj.com)
a protease inhibitor combination (PI), amprenavir/ritonavir (Agenerase and Norvir). (dukehealth.org)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

The study also considered induction therapy, an optional addition to maintenance therapy used in over half of transplant centers in the U.S. In induction therapy, patients are given a high dose of immunosuppression at the time of transplantation for a short duration -- three to 14 days, with drugs such as basiliximab, daclizumab, alemtuzumab, or antithymocyte globulin. (sciencedaily.com)
This phase 1 trial represents the first clinical study to our knowledge to evaluate a single priming dose of targeted radioligand therapy coupled with immune checkpoint inhibition in patients with metastatic prostate cancer," said study first author Rahul Aggarwal , MD, a genitourinary medical oncologist and UCSF professor of Medicine. (ucsf.edu)
We observed lasting responses in a subset of patients, in whom there was an increase in circulating T cells and decreased activity of immunosuppressive cells following the priming dose of 177 Lu-PSMA-617. (ucsf.edu)
Patients received a priming dose of 177 Lu-PSMA-617 followed by maintenance pembrolizumab (a sustained dose) administered intravenously every 3 weeks. (ucsf.edu)
Patients with previously untreated Revised International Prognostic Scoring System intermediate-/high-/very high-risk MDS received magrolimab intravenously as a priming dose (1 mg/kg) followed by ramp-up to a 30 mg/kg once-weekly or once-every-2-week maintenance dose. (nih.gov)
We are very excited about our continued study of this combination with its advancement into dose expansion this year. (businesswire.com)
This portion of the study was designed to evaluate the safety, tolerability, and pharmacokinetics of the combination, and determine the maximum tolerated dose and/or recommended Phase 2 dose. (businesswire.com)
Results suggest that lifirafenib in combination with mirdametinib demonstrated a favorable safety profile, with low incidence of dose limiting toxicities and treatment-emergent adverse events that led to dose discontinuations. (businesswire.com)
These data support the advancement of this combination into the dose-expansion portion of the study, which will focus on a biomarker selected patient population with a tumor agnostic approach. (businesswire.com)
The dose and combination of treatments participants receive will depend on their cancer type and when they enroll in the study. (facingourrisk.org)
A double-blind, randomized and comparative clinical trial study was designed to characterize the efficacy and safety of a fixed dose combination of magaldrate (800 mg)/dom peridone (10 mg) against domperidone alone (10 mg), in patients with gastroesophageal reflux symptoms. (scirp.org)
One hundred patients with gastroesophageal reflux diagnosed by Carlsson scale were randomized to receive a chewable tablet of a fixed dose of magaldrate/domperidone combination or domperidone alone four times each day during a month. (scirp.org)
S. Rodríguez-Sánchez, H. Rocha-González, C. Valle-Laisequilla, J. Rodríguez-Silverio, F. Flores-Murrieta and J. Reyes-García, "Fixed Dose Combination of Magaldrate Plus Domperidone Is More Effective than Domperidone Alone in the Treatment of Patients with Gastroesophageal Reflux Symptoms: A Randomized Double-Blind Study," Pharmacology & Pharmacy , Vol. 5 No. 2, 2014, pp. 216-223. (scirp.org)
The fixed dose combination of amlodipine/benazepril would be superior to HCTZ/benazepril in reducing cardiovascular mortality and morbidity in high-risk patients with hypertension. (acc.org)
After a screening phase, patients with hypertension were randomized to either fixed dose combination of amlodipine 5 mg/benazepril 20 mg or HCTZ 12.5 mg/benazepril 20 mg. (acc.org)
1 The investigational combination immunotherapy regimen demonstrated an ORR of 86.6 percent (71/82) across all dose levels, and an ORR of 96.3 percent (26/27) among patients receiving the recommended Phase 2 regimen (RP2R). (jnj.com)
This randomized phase I/II trial studies the side effects and best dose of rintatolimod when given together with vaccine therapy and sargramostim (GM-CSF) to see how well it works in treating patients with stage II-IV human epidermal growth factor receptor 2 (HER2)-positive breast cancer. (her2support.org)
Small intestinal bacterial overgrowth (SIBO) - the patient is either given a challenge dose of glucose, also known as dextrose (75-100 grams), or lactulose (10 grams). (wikipedia.org)
Intravenous high dose penicillin treatment, for five weeks, was started in combination with gentamicin, for the first 10 days. (cdc.gov)

Combining the new breast cancer drug palbociclib with paclitaxel (Taxol) shrank tumors in nearly half of patient with estrogen-receptor (ER) positive breast cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania. (news-medical.net)
Although the trial wasn't designed to test whether the combination is more effective against breast tumors than paclitaxel, the patients' responses were promising. (news-medical.net)
By examining samples taken from a patient through the course of her treatment with palbociclib, the team found that as the tumors became resistant, the cells more than doubled their expression of several cell-cycle-driving genes, including PLK1, TOP2A, CDK1, and BUB1. (news-medical.net)
The early clinical data reported here demonstrate the potential of this vertical combination strategy in addressing the substantial unmet medical need represented by patients with tumors driven by these genetic alterations. (businesswire.com)
Of the 4 endometrial cancer patients treated, 2 (50%) had objective responses in tumors that harbor BRAF fusion mutation or KRAS mutation, respectively. (businesswire.com)
Of the 11 patients with NSCLC treated, 2 (18%) had objective responses in tumors that harbor NRAS mutation or BRAF V600E mutation, respectively. (businesswire.com)
Roughly half of patients with advanced ovarian cancer have homologous recombination deficiency (HRD)-positive tumors, including those with a BRCA mutation, and one in four women have a BRCA mutation. (merck.com)
An ongoing phase II study (KEYNOTE-495/KeyImPaCT) led by a researcher at Yale Cancer Center reveals that combining pembrolizumab with other treatments reduced the size of target tumors, resulting in a higher response rate for patients with advanced NSCLC. (worldpharmanews.com)

We view vertical inhibition approaches, such as this novel combination, as a promising strategy to improve outcomes in biomarker-defined subgroups of patients that lack efficacious treatments for their cancers. (businesswire.com)
Yet despite these advances, unfortunately most AML patients are not cured, and long-term AML outcomes remain poor. (lls.org)
Yet despite these "favorable outcomes", relapse is nearly inevitable and the outcomes of patients at the time of venetoclax-combination therapy are particularly dismal. (lls.org)
Daratumumab appeared to improve poor outcomes associated with high risk cytogenetics, and these data support its consistent clinical benefit in combination with two of the most widely used treatment classes. (jnj.com)
Methods: An economic model was constructed to estimate costs and outcomes over patients' lifetimes from start of therapy. (rti.org)
The most important take-home message from this late-breaking study is that it demonstrates a shift away from chemotherapy to targeted therapy to improve outcomes for our patients," said Aaron T. Gerds, MD, MS , of Cleveland Clinic Taussig Cancer Center. (ascopost.com)
These findings reinforce the importance of personalized medicine in improving outcomes for patients with NSCLC and pave the way for further advancements in pembrolizumab combination therapies," said Herbst. (worldpharmanews.com)
In addition, the data may be used to examine patient outcomes in the context of population trends (19). (cdc.gov)

Results from the trial demonstrated measurable anti-tumor activity with minimal toxicity in patients with mCRPC. (ucsf.edu)
This is a Phase 2 study designed to determine the preliminary anti-tumor activity and confirm the safety of VV1 in combination with cemiplimab. (yalecancercenter.org)
The interim results from the study showed that each of the treatment combinations provided anti-tumor activity, particularly in group IV. (worldpharmanews.com)

The Phase 3 PAOLA-1 trial evaluated LYNPARZA in combination with bevacizumab as first-line maintenance therapy in patients with advanced ovarian cancer, who were without evidence of disease after surgery or following response to platinum-based chemotherapy. (merck.com)
The Scottish Medicines Consortium (SMC) has confirmed that another immunotherapy treatment in combination with certain conventional chemotherapy drugs is to be made available on the NHS in Scotland. (roycastle.org)
It means that, for the first time, patients across the UK with this form of lung cancer will have access to pembrolizumab in combination with chemotherapy, rather than having to wait to finish a course of chemotherapy. (roycastle.org)
The decision comes after pembrolizumab, in combination with platinum-based doublet chemotherapy, was associated with a progression-free survival and overall survival benefit over platinum-based doublet chemotherapy in patients with treatment naïve metastatic squamous NSCLC. (roycastle.org)
The SMC has accepted pembrolizumab in combination with chemotherapy for the initial treatment of metastatic squamous NSCLC in adults. (roycastle.org)
First-line therapy with the combination of ibrutinib (Imbruvica) and rituximab (Rituxan) reduced disease progression by two-thirds compared with standard chemotherapy using fludarabine, cyclophosphamide, and rituximab (FCR) in younger patients with chronic lymphocytic leukemia (CLL), according to the late-breaking results of the ECOG-ACRIN E1912 trial presented at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition. (ascopost.com)
1 This is the first phase III trial to compare the newer chemotherapy-free regimen with standard-of-care FCR in younger patients with CLL. (ascopost.com)
AstraZeneca has reported that a combination of its drug Imfinzi (durvalumab) with chemotherapy improved progression-free survival (PFS) in the ongoing Phase III POSEIDON clinical trial involving treatment-naïve patients with stage IV non-small cell lung cancer (NSCLC). (clinicaltrialsarena.com)
In the open-label, randomised, multi-centre POSEIDON trial, Imfinzi is being tested in combination with platinum-based chemotherapy, as well as with tremelimumab plus chemotherapy as a first-line treatment. (clinicaltrialsarena.com)
The trial is being conducted at 153 sites in 18 countries and compared the combination therapy to chemotherapy alone. (clinicaltrialsarena.com)
Its primary endpoints for the Imfinzi and chemotherapy combination are PFS and overall survival (OS). (clinicaltrialsarena.com)
Similar improvements were observed with the Imfinzi plus tremelimumab and chemotherapy combination. (clinicaltrialsarena.com)
The triple combination also demonstrated a safety profile similar to that of the Imfinzi and chemotherapy combination, without any increase in treatment discontinuation. (clinicaltrialsarena.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)

The combination showed antitumor activity in patients with various KRAS, NRAS, and BRAF mutations across several solid tumor types, including low-grade serous ovarian cancer (LGSOC), non-small cell lung cancer (NSCLC), and endometrial cancer. (businesswire.com)
This decision makes pembrolizumab, which also has the trade name Keytruda, the first immunotherapy to be approved for use as a first line treatment, in combination with chemotherapies carboplatin and either paclitaxel or nab-paclitaxel, for patients in Scotland with metastatic squamous non-small cell lung cancer (NSCLC) in adults. (roycastle.org)
While pembrolizumab is an approved treatment for patients with stage III non-small cell lung cancer (NSCLC), only some patients respond to this therapy. (worldpharmanews.com)
Additional research from the trial will provide further insight on optimal combinations targeting specific molecular subtypes in NSCLC and other tumor types. (worldpharmanews.com)

This is the first FDA approval for an anti-PD-L1 therapy as part of a combination regimen for patients with advanced RCC. (pfizer.com)
By combining teclistamab and talquetamab, two bispecific antibodies that have demonstrated high efficacy responses in targeting distinct antigens, we evaluated the potential of this unique combination regimen for patients who were resistant or refractory to multiple lines of therapy," said Yael Cohen, M.D., Head of Myeloma Unit, Hematology Institute, Tel-Aviv Sourasky Medical Center, Israel, and principal study investigator. (jnj.com)

The response rates were the same for the high-risk subgroup of patients. (mdanderson.org)
In an exploratory subgroup analysis of HRD-positive patients, LYNPARZA plus bevacizumab provided a clinically meaningful improvement in OS, reducing the risk of death by 38% (HR=0.62 [95% CI, 0.45-0.85]) versus bevacizumab alone. (merck.com)

To prevent chronic rejection, the most common cause of death after a lung transplant, patients must take immunosuppressive drugs for the rest of their lives. (sciencedaily.com)
They singled out an immunosuppressive drug called sirolimus, in a class of drugs called cell cycle inhibitors, based on a few small, long-term studies that found dramatically improved survival, reduced incidence of chronic rejection, and improved lung function in lung transplant patients who took sirolimus. (sciencedaily.com)
A combination of ibrutinib and venetoclax was found to provide lasting disease remission in patients with newly diagnosed chronic lymphocytic leukemia (CLL), according to researchers at The University of Texas MD Anderson Cancer Center . (mdanderson.org)
Chronic obstructive pulmonary disease (COPD) is associated with significant mortality and morbidity and patients with COPD are at increased risk of contracting pneumonia 1 - 3 . (ersjournals.com)
WASHINGTON-(BUSINESS WIRE)-A breakthrough study presented today at the annual meeting of the Congress of Neurological Surgeons found that a combination of remote cognitive behavioral therapy with in-home virtual reality sessions, Vx® Therapy, is effective in reducing pain and behavioral health conditions in patients with chronic cervical and lumbar pain. (digitalproducer.com)
While cognitive behavioral therapy (CBT) has been proven effective for chronic pain and associated anxiety, depression, and physical disability, many patients cannot access this therapy because of a shortage of trained care providers, lack of adequate transportation for in-person encounters, and inconsistent engagement in the therapy. (digitalproducer.com)
In the study, 145 workers' compensation patients with chronic degenerative neck/back pain participated in a guided 14-week virtual reality and cognitive behavioral therapy program, Vx® Therapy. (digitalproducer.com)
Scholars@Duke publication: Adherence to combination therapy enhances sustained response in genotype-1-infected patients with chronic hepatitis C. (duke.edu)
We evaluated the impact of adherence to combination therapy with interferon or peginterferon plus ribavirin in chronic hepatitis C patients. (duke.edu)

In the current study, Dr. Taylor-Cousar and colleagues from 91 study sites in the United States, Canada and Europe, evaluated 475 patients with two copies of 508del who took the ivacaftor-tezacaftor combination or a placebo for 24 weeks. (nationaljewish.org)
The study has identified a drug combination that appears to significantly extend patient survival. (sciencedaily.com)
Another immunosuppressive medication, tacrolimus, is currently used in the vast majority of lung transplant recipients and was common to all patients in the study. (sciencedaily.com)
We conducted a retrospective and observational subanalysis of patients from the International Bedaquiline Study Group study who were undergoing treatment with bedaquiline and delamanid. (cdc.gov)
We consecutively enrolled patients ≥15 years of age from the International Bedaquiline Study Group study who underwent treatment during January 1, 2008-August 30, 2016, on the basis of their exposure to both bedaquiline and delamanid during the intensive and/or continuation phase of the study. (cdc.gov)
The study included patients with mCRPC and prior treatment with one or more androgen signaling inhibitors, medications that reduce the production of the male sex hormone androgen that contributes to the cancer. (ucsf.edu)
Within the study cohort, 5% of patients had a complete response to the therapy, 47% had a confirmed partial response, 28% of patients had stable disease and 21% had progressive disease. (ucsf.edu)
A second study (Abstract P4-13-04), to be presented Friday provides new clues to how breast cancer develops resistance to the palbociclib, a common occurrence among many patients who take the drug. (news-medical.net)
The study focused on a Penn Medicine patient who was first diagnosed with breast cancer in 1999. (news-medical.net)
Findings from the single-institution Phase II study were published today in JAMA Oncology and provide the longest follow-up data on patients treated with this drug regimen. (mdanderson.org)
MD Anderson researchers previously reported results from this study showing that ibrutinib and venetoclax were effective when given together for high-risk and older patients with the disease. (mdanderson.org)
A total of 75% of patients achieved bone marrow U-MRD remission at any time during the study. (mdanderson.org)
This study was conducted to investigate the usefulness of (18)F-FMT PET in combination with fluorine-18-fluorodeoxyglucose ((18)F-FDG) PET for the diagnosis of sarcoidosis in patients with suspected malignancy. (nih.gov)
The combination will depend on their cancer type and when they enrolled in the study. (facingourrisk.org)
WESTMINSTER, Colo.--(BUSINESS WIRE)--Allos Therapeutics, Inc. (NASDAQ:ALTH) today reported interim results from the Company's ongoing Phase 1 combination study of FOLOTYN® (pralatrexate injection) and bexarotene in patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL). (biospace.com)
Innovative laboratory analyses will help determine the depth of response and evaluate shifts in leukemia subpopulations on the clinical study, through single-cell sequencing and proteomic analyses of patient study samples. (lls.org)
Additionally, data from the Phase 1b MMY1001 study will show the potential of daratumumab in combination with carfilzomib, lenalidomide and dexamethasone (KRd) for newly diagnosed patients with multiple myeloma. (jnj.com)
This pilot study suggests that a combination of biomarkers with NSE could be beneficial for improving early prognostication of long-term outcome following OHCA. (lu.se)
The objective of this study was to describe the clinical course of severe and complicated pandemic (H1N1)v infection treated with oral oseltamivir and inhaled zanamivir in a series of intensive care patients. (unboundmedicine.com)
In a post hoc analysis of the TOwards a Revolution in COPD Health (TORCH) study, we analysed and identified potential risk factors for adverse event reports of pneumonia in this randomised, double-blind trial comparing twice-daily inhaled salmeterol (SAL) 50 μg, fluticasone propionate (FP) 500 μg, and the combination (SFC) with placebo in 6,184 patients with moderate-to-severe COPD over 3 yrs. (ersjournals.com)
The TOwards a Revolution in COPD Health (TORCH) study assessed the impact of the ICS fluticasone propionate (FP) in combination with the long-acting β-agonist salmeterol (SAL) in reducing all-cause mortality 17 . (ersjournals.com)
Prior to this study, ibrutinib-based therapy had not been compared with FCR for younger patients with CLL. (ascopost.com)
CHICAGO, June 3, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson announced today the first-ever results from the Phase 1b RedirecTT-1 study of TECVAYLI ® (teclistamab-cqyv), a first-in-class BCMAxCD3 bispecific antibody, and talquetamab, a first-in-class GPRC5DxCD3 bispecific antibody, showing a high overall response rate (ORR) among patients with relapsed or refractory multiple myeloma (RRMM). (jnj.com)
The high overall response rates characterized in this study are encouraging and support the continued evaluation of this regimen as a combination therapy. (jnj.com)
1 Eighty-two patients across all study cohorts and 27 patients treated at the RP2R were evaluable for response. (jnj.com)
In addition to results from the COMBI-d study, long-term data from a Phase I-II study showed a three-year OS rate of 38% (95% CI, 25%, 51%) after treatment with the combination of Tafinlar and Mekinist in all patients with BRAF V600 E/K mutation-positive metastatic melanoma. (worldpharmanews.com)
Safety results from this study were consistent with those observed in other trials evaluating the combination. (worldpharmanews.com)
The study randomized 423 patients from investigative sites in Australia, Europe and North and South America. (worldpharmanews.com)
The purpose of this research study is to determine the effectiveness and safety of envafolimab, an experimental drug that is not approved for use, when given alone or in combination with ipilimumab to stimulate the immune system to attack cancer cells. (froedtert.com)
The study will concurrently enroll patients with four distinct advanced malignancies in 5 separate tumor cohorts. (yalecancercenter.org)
Of the nine patients who had detectable viral RNA in the baseline sample, only three cleared virus from both compartments by the end of the study. (bmj.com)
These first results from the RedirecTT-1 study demonstrate the potential impact of combining teclistamab and talquetamab to overcome resistance mechanisms and in patients with EMD, and we look forward to evaluating this combination regimen further. (itbusinessnet.com)
In the study, 94.1 percent (32/34) of patients at the RP2R and 96.8 percent (90/93) of the overall study population had one or more treatment-emergent adverse events (TEAEs). (itbusinessnet.com)
In this study, patients were categorized into four biomarker-defined groups based on their gene expression and amount of gene mutation in the cancer cells. (worldpharmanews.com)
The study assessed the objective response rate (ORR), or the percentage of patients who had a partial or complete response to the treatment, as well as progression-free survival (PFS), and safety. (worldpharmanews.com)
The study reported ORR ranges of 0% to 12% in group I, 27.3% to 33.3% in group II, 13.6% to 40.9% in group III, and 50% to 60% in group IV, with ranges encompassing the results of the different treatment combinations. (worldpharmanews.com)
Results From June 2019 to early study termination due to safety concerns on July 2020, 17 patients were enrolled (FUL: n=12, LET: n=5). (bmj.com)
As a practicing neurosurgeon, it is groundbreaking to have something to address pain that treats the entire patient, not just the symptoms of pain," said Nicholas Theodore, M.D., co-author of the study, practicing neurosurgeon and Professor of Neurosurgery at Johns Hopkins University. (digitalproducer.com)
Barcelona - Combinations of drugs can significantly reduce the concentration of HIV in patients' bodies, even in those with advanced HIV disease, according to interim results of a study presented today (July 9, 2002) at the XIV International AIDS Conference in Barcelona, Spain. (dukehealth.org)
The CLASS study enrolled 291 HIV-positive patients with initial viral loads greater than 5,000 copies/mL. (dukehealth.org)
Forty-two percent of the patients had viral loads of more than 100,000 copies/mL at the beginning of the study. (dukehealth.org)
Patients who had previously used antiretroviral treatments for more than two weeks were excluded from the study. (dukehealth.org)
We conducted a prospective observational study on 24 CF patients with CF-related diabetes requiring insulin therapy , with the aim to evaluate the effectiveness of ETI on glucose metabolism , glucose variability and body composition . (bvsalud.org)
The most sophisticated study is videourodynamics, the criterion standard in the evaluation of a patient with incontinence. (medscape.com)
ABSTRACT We aimed to study the prevalence of the side-effects of statins among Iranians patients admitted to a cardiac-specialized hospital and had taken statins prior to hospitalization. (who.int)
This study examined the relationships between SSB consumption and demographic, health behavior, health service, and health condition characteristics of adult patients of a network of federally qualified health centers (FQHCs) in a low-income, urban setting. (cdc.gov)
The primary objective of this study was to examine the relationships between SSB consumption and demographic, health behavior, health service, and health condition characteristic variables of adult patients served by a network of hospital-affiliated federally qualified health centers (FQHCs) in a low-income urban setting. (cdc.gov)

Objective To determine the effect of combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in the secondary prevention of all cause mortality in patients with ischaemic heart disease. (bmj.com)
Exposure was current use of different combinations of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors before death in cases, or the equivalent date in controls. (bmj.com)
1 - 5 Although combinations of drugs (as proposed in the Polypill) 6 have been received with enthusiasm, we found no direct evidence evaluating the effects of statins, aspirin, β blockers, and angiotensin converting enzyme inhibitors in combination. (bmj.com)
D. Sifrim and F. Zerbib, "Diagnosis and Management of Patients with Reflux Symptoms Refractory to Proton Pump Inhibitors," Gut, Vol. 61, No. 9, 2012, pp. 1340-1354. (scirp.org)
This is the first combination of BRAF/MEK inhibitors to demonstrate a statistically significant overall survival benefit for this patient population in two Phase III studies. (worldpharmanews.com)

The mortality in patients not receiving ECMO treatment was 16.6% (2/12). (unboundmedicine.com)
The mortality in these patients was high despite combined antiviral treatment with oseltamivir and zanamivir. (unboundmedicine.com)
Furthermore, patients with COPD who are hospitalised for pneumonia have been reported to exhibit higher mortality than patients without COPD 4 - 6 . (ersjournals.com)
Patients were followed for 3 yrs with the primary outcome being all-cause mortality. (ersjournals.com)
Initial predictors for mortality previously reported in patients with myositis-associated ILD were used as variables and included age, sex, disease duration, classification of myositis, requirement of supplemental oxygen, anti-aminoacyl tRNA synthetase (ARS) antibody, anti-melanoma differentiation-associated gene 5 (MDA5) antibody, and serum levels of C-reactive protein (CRP) and Krebs von den Lungen-6 (KL-6). (frontiersin.org)
In particular, interstitial lung disease (ILD) is one of the major manifestations associated with poor mortality in patients with polymyositis (PM)/dermatomyositis (DM) ( 2 ). (frontiersin.org)
The goal of this trial was to evaluate the safety and efficacy of the combination of amlodipine/benazepril, compared with hydrochlorothiazide (HCTZ)/benazepril in reducing cardiovascular morbidity and mortality in high-risk patients with systolic hypertension. (acc.org)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)

The high response rate we saw suggests this combination may hold benefits for patients over paclitaxel alone. (news-medical.net)
To begin to test this concept in the clinic, DeMichele and colleagues, including lead author Amy S. Clark, MD, MSCE, an assistant professor of Hematology-Oncology in the Abramson Cancer Center, treated 27 breast cancer patients with alternating doses of palbociclib - administered daily for several days at a time - and paclitaxel administered once per week. (news-medical.net)
That seemed better than what we would have expected from paclitaxel alone, but the only way to know the difference for certain is with a randomized clinical trial of the combination versus the single drug,' DeMichele said. (news-medical.net)

CHICAGO and RARITAN, NJ, June 4, 2017 - Janssen Research & Development, LLC today announced new data from updated analyses of the pivotal Phase 3 CASTOR and POLLUX clinical studies, demonstrating that DARZALEX ® (daratumumab) in combination with bortezomib and dexamethasone, or lenalidomide and dexamethasone, improved progression-free survival (PFS) and the overall response rate (ORR) for previously-treated patients with multiple myeloma, regardless of cytogenetic risk. (jnj.com)
These compelling findings from the Phase 3 CASTOR and POLLUX trials show daratumumab delivered deep and durable responses for previously-treated patients, regardless of cytogenetic risk," said Dr. Katja Weisel, Associate Professor, Department of Hematology and Oncology, University Hospital of Tuebingen, Tuebingen, Germany. (jnj.com)
Recently, the United States (US) Food and Drug Administration conditionally approved olaratumab in combination with doxorubicin (Olara + Dox) based on a randomized phase II trial that reported a significant 11.8-month improvement in median survival versus single-agent doxorubicin (Dox). (rti.org)
Biomarker-directed, pembrolizumab-based combination therapy in non-small cell lung cancer: phase 2 KEYNOTE-495/KeyImPaCT trial interim results. (worldpharmanews.com)

Patients in each of the four groups were then randomly assigned to receive pembrolizumab (also marketed under the name Keytruda) in combination with one of three other cancer treatments: lenvatinib (also known as Lenvima), quavonlimab, or favezelimab. (worldpharmanews.com)

The majority of patients achieved bone marrow MRD remission and no patients on the trial had CLL disease progression. (mdanderson.org)
LYNPARZA plus bevacizumab also improved median progression-free survival (PFS) to nearly four years (46.8 months) versus 17.6 months with bevacizumab plus placebo, and 46.1% of patients who received LYNPARZA in combination with bevacizumab remain progression free versus 19.2% of patients who received bevacizumab alone. (merck.com)
Progression-free and overall survival were based on survival analysis of patient-level data and a meta-analysis. (rti.org)
The management of ILD in patients with PM/DM aims to ameliorate, stabilize, or slow its progression based on the disease behavior of ILD ( 3 ). (frontiersin.org)
Since the clinical course, response to treatment, and prognosis are highly variable among patients with myositis-associated ILD ( 3 , 5 ), the treatment regimen is decided based mainly on the progression speed and severity of ILD. (frontiersin.org)
The combination of ibrutinib and rituximab reduced the likelihood of disease progression by 65% compared with FCR. (ascopost.com)
The analysis for the combination also showed median progression-free survival (PFS) of 11.0 months, overall response rate (ORR) of 69%, and median duration of response (DoR) of 12.9 months[1]. (worldpharmanews.com)

p=0.4118) in patients with newly diagnosed advanced ovarian cancer. (merck.com)

Magrolimab + azacitidine was well tolerated with promising efficacy in patients with untreated higher-risk MDS, including those with TP53 mutations. (nih.gov)
Among 62 efficacy-evaluable patients, 14 patients (23%) had confirmed objective responses. (businesswire.com)

Patients All patients with a first diagnosis of ischaemic heart disease between January 1996 and December 2003. (bmj.com)
Controls were patients with ischaemic heart disease who were matched for age, sex, and year of diagnosis and were alive at the time their matched case died. (bmj.com)
Results 13 029 patients had a first diagnosis of ischaemic heart disease (incidence rate 338 per 100 000 person years). (bmj.com)
Positive diagnosis for a lactulose SIBO breath test - typically positive if the patient produces approximately 20 ppm of hydrogen and/or methane within the first 60-90 minutes (indicates bacteria in the small intestine), followed by a much larger peak (colonic response). (wikipedia.org)
Most patients have multiorgan involvement at the time of diagnosis but tend to have one dominant phenotype. (msdmanuals.com)

Mutations in IDH1 or IDH2 occur in approximately 20% of patients with acute myeloid leukemia (AML), and occur with increasing frequency in older patients. (lls.org)

The study's approach of categorizing patients into biomarker-defined subgroups allows us to identify potential unique resistance mechanisms and tailor treatment strategies accordingly," said Herbst. (worldpharmanews.com)

It was observed in TORCH that despite a reduction in moderate and severe COPD exacerbations with FP either alone or as combination therapy (SFC), there was an increase in the probability of having a pneumonia reported as an adverse event (AE) compared with patients randomised to placebo or SAL. (ersjournals.com)
The results of this large, randomized trial indicate that a single combination therapy of amlodipine/benazepril is superior to HCTZ/benazepril in the reduction in blood pressure as well as cardiovascular endpoints in patients with high-risk hypertension. (acc.org)
There was at least a 30% reduction in the target tumor size in more than 58% of patients in group IV. (worldpharmanews.com)
While patients in the nNRTI group had the greatest reduction in viral loads to less than 50 copies/mL, all three groups showed impressive changes in their viral loads," said Bartlett. (dukehealth.org)
This article describes the oral rehabilitation of a patient with the Combination Syndrome where the surgical reduction of flaccid mucosa was not performed, using a modified technique of functional impression in two steps, with the objective of generating forces and less distortion in flaccid mucosa during functional impression. (bvsalud.org)
It is indicated for the reduction of cytotoxicity when used in combination with 5-fluorouracil in the treatment of colorectal cancer and for the treatment of megaloblastic anemia due to folic acid deficiency when folic acid cannot be replaced orally. (janusinfo.se)

This project focuses on AML patients with IDH1 or IDH2 mutations, with a clinical trial evaluating a combination of three agents which are effective in IDH-mutated AML. (lls.org)
Patients with AML harboring IDH1 or IDH2 mutations respond particularly well to venetoclax-combination therapy, with a remission rate of ~70% and median survival of 24 months. (lls.org)
The indication CHMP recommended is applicable to all patients, with or without gene mutations. (pfizer.com)

Participants with metastatic castration-resistant prostate cancer will one of the following: NUV-868 alone, NUV-868 in combination with enzalutamide or NUV-868 in combination with olaparib. (facingourrisk.org)
These findings further reinforce the rationale for the treatment of metastatic melanoma with this combination. (worldpharmanews.com)

Researchers followed 80 previously untreated patients with a median age of 65 years, 30% of whom were over age 70. (mdanderson.org)

These long-term results show that two years of oral targeted therapy can achieve lasting disease remission for patients with CLL. (mdanderson.org)
10 Although randomised trials provide relatively unbiased evidence of the effectiveness of interventions in selected patients, the application of trial results to representative populations of patients is often inaccurate. (bmj.com)
Our preliminary results suggest that even patients with advanced HIV infection can benefit substantially from currently available therapies," said Bartlett. (dukehealth.org)
The challenge to researchers and physicians is to find the combinations that will achieve the best long-term results with the fewest side effects. (dukehealth.org)
If the patient produces both hydrogen and methane then the values are typically added together and the mean of the numbers is used to determine positive results, usually 15 ppm over the lowest preceding value. (wikipedia.org)

Multiple myeloma remains incurable with patients often experiencing resistance to available treatment options. (itbusinessnet.com)

Conclusions Intensive COBRA or COBRA-light therapy has major, comparably favourable effects on disease activity, functional ability and radiological outcome after 1 year in patients with early RA. (bmj.com)
Even when coinfected patients receive proper treatment, they relapse repeatedly and the outcome frequently is fatal. (who.int)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

To see what might help lung transplant recipients live longer, researchers analyzed US lung transplant data, focused on immunosuppression regimes, and found a drug combination that appears to significantly extend patient survival. (sciencedaily.com)

After 12 cycles of combination therapy, 56% of patients achieved bone marrow U-MRD, and after 24 cycles of combination therapy, 66% of patients achieved bone marrow U-MRD remission. (mdanderson.org)

Patients taking the ivacaftor-tezacaftor combination also experienced fewer respiratory adverse events, including respiratory infections, cough, headache and fatigue, than did those taking placebo. (nationaljewish.org)
Although these drugs are increasingly used in combination in complicated cases ( 8 - 11 ), public health officials are concerned that the co-administration of bedaquiline and delamanid could increase the occurrence of adverse events, particularly for QT prolongation, which might occur more often when these drugs are combined with other TB drugs that prolong the QT interval (i.e., fluoroquinolones and clofazimine). (cdc.gov)
The combination therapy showed comparatively low toxicity levels, was not damaging to patients' blood, and had a manageable rate of immune-related adverse events. (ucsf.edu)
At least one adverse event was reported in 96% of the patients in both groups. (bmj.com)

The U.S. Food and Drug Administration (FDA) has already approved a similar combination of Ivacaftor and Lumacaftor for patients who have two copies of the most common CFTR mutation, F508del. (nationaljewish.org)
Effects of elexacaftor / tezacaftor / ivacaftor triple combination therapy on glycaemic control and body composition in patients with cystic fibrosis-related diabetes. (bvsalud.org)
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are a group of new drugs for the treatment of cystic fibrosis (CF) and elexacaftor + tezacaftor + ivacaftor (ETI) triple combination therapy has been approved as first choice therapy in the treatment of patients with at least 1 copy of F508del variation. (bvsalud.org)

The group of patients using abacavir and lamivudine in combination with an nNRTI (efavirenz) experienced the greatest decline in viral loads, with 75 percent of patients having viral loads of less than 50 copies/mL at the end of 48 weeks. (dukehealth.org)

They establish the combination of ibrutinib plus rituximab as the most effective first-line treatment to date for these patients. (ascopost.com)

Correspondingly, primary care centers that incorporate patient-reported health behaviors such as SSB consumption into their electronic health record (EHR) systems can share this information with public health agencies and help them coordinate health promotion among patients and other populations (17,18). (cdc.gov)

What we found could improve survival of lung transplant patients on a larger scale. (sciencedaily.com)

Optimal management of patients with bilateral pneumonia and respiratory failure caused by (H1N1)v still needs to be determined. (unboundmedicine.com)

Denver - Researchers at National Jewish Health and around the world report in the New England Journal of Medicine that a novel combination of medications improves lung function and reduces disease exacerbations in cystic fibrosis patients with the most common form of the disease. (nationaljewish.org)

Randomised controlled trials have shown that statins improve the survival of patients with ischaemic heart disease. (bmj.com)

Essentially, patients were grouped by similar tumor microenvironment. (worldpharmanews.com)

range, 2-10 for patients in the RP2R dosing cohort, n=34). (jnj.com)
1 The median follow-up for patients receiving the RP2R was 8.1 months (range, 0.7-15.0), and median PFS was NE for patients in the RP2R cohort (95 percent CI: 9.9-NE). (jnj.com)
One patient with a prior treatment history in the FUL cohort was excluded. (bmj.com)

and 1 patient with multiple bone lesions), 3 patients with occurrence of bilateral hilar lymphadenopathy in cancer patients, and 4 patients with multiple nodules mimicking pulmonary metastasis. (nih.gov)

Moreover, patients with more severe disease are often treated with inhaled and/or systemic corticosteroids in an attempt to either decrease the rate of exacerbations or provide symptomatic benefit. (ersjournals.com)
Protocolised addition of etanercept was often not implemented by treating rheumatologists, and patients receiving it appeared to have limited added benefit, probably because of low disease activity levels at its initiation. (bmj.com)
RePub, Erasmus University Repository: Induction therapy with a combination of fumarates and cyclosporine: A benefit for the patient? (eur.nl)

We know that lung function correlates with survival, so that is great news for patients with cystic fibrosis and the doctors who care for them. (nationaljewish.org)
Patients suffer repeated infections of the lungs, which result in lung damage over time and eventually death. (nationaljewish.org)
Those taking the placebo experienced a 0.6 percent decline in lung function (forced expiratory volume in one second, or FEV 1 ) compared to a 3.4 percent improvement for those taking the experimental combination. (nationaljewish.org)
Lung transplantation can prolong the lives of patients with end-stage lung disease, but the median survival rate after lung transplant is less than six years, which has improved only slightly in recent decades. (sciencedaily.com)
Immunosuppression, in turn, may predispose patients to infections and cancers, the second- and third-leading causes of post-lung transplant death. (sciencedaily.com)
Using a database of over 9,000 lung transplant patients maintained by the United Network for Organ Sharing (UNOS), the researchers categorized patients by their immunosuppression regimen and compared survival rates. (sciencedaily.com)
The majority of patients in the database, nearly 5,800, were given MMF plus tacrolimus, a combination that has become the de facto standard immunosuppression after lung transplant. (sciencedaily.com)
In a control group of patients with lung cancer, SUVs for (18)F-FDG and (18)F-FMT were 6.34 +/- 2.52 and 1.54 +/- 0.82, respectively. (nih.gov)

For the first time ever, physicians and surgeons have a tool to help treat patients without the need for dangerous opioids or additional procedures. (digitalproducer.com)
physicians strive to reduce patients' viral loads to below the limits of detection. (dukehealth.org)

1 Patients who received the RP2R achieved an ORR of 96.3 percent (26/27). (jnj.com)
1 Patients with EMD who received the RP2R achieved an 85.7 percent (6/7) ORR, and median duration of response was not reached at a median follow-up of 7.2 months (range, 0.7-14.2). (jnj.com)

However, that combination has a number of drug-drug interactions and negative side effects that prevent some people from using it. (nationaljewish.org)
Some participants will receive a second drug in combination with NUV-868. (facingourrisk.org)
Darmstadt, Germany and New York, US, May 14, 2019 - Merck KGaA, Darmstadt, Germany, which operates its biopharmaceutical business as EMD Serono in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) in combination with INLYTA® (axitinib) for the first-line treatment of patients with advanced renal cell carcinoma (RCC). (pfizer.com)
Researchers led by John A. Bartlett, M.D. , professor of medicine at Duke University Medical Center (Durham, NC), found that at least 75 percent of never-treated HIV-positive patients had "viral loads" decrease to the target level of less than 400 copies/mL when treated for 48 weeks using any of three drug combinations. (dukehealth.org)
The actual treatment administered was verified from drug dispensing/return records and patient diaries. (duke.edu)
The drug is also indicated in 11 countries for previously treated advanced bladder cancer patients. (clinicaltrialsarena.com)
For these reasons, patients may not comply with treatment (if they began) and drug resistance may emerge. (who.int)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

Serum samples from cardiac arrest patients, treated at 33°C for 24 hours, were collected serially at 12, 24, and 48 hours after cardiac arrest. (lu.se)
Sixty-two patients with OHCA of presumed cardiac cause were included. (lu.se)

Regimens13

Solid tumors5

Monotherapy8

Inhibitor14

Dose19

Tumors8

Outcomes8

Anti-tumor activity3

Chemotherapy15

NSCLC4

Regimen for patients2

Subgroup2

Chronic9

Study47

Inhibitors5

Mortality8

Paclitaxel3

Phase4

Pembrolizumab1

Progression7

Newly diagnosed1

Efficacy2

Diagnosis5

Approximately 201

Biomarker1

Reduction6

Mutations3

Metastatic2

Previously untreated1

Results5

Multiple myeloma1

Outcome3

Significantly1

Remission1

Adverse4

Ivacaftor3

Lamivudine1

Ibrutinib plus1

Populations1

Improve survival1

Management of patients1

Improves1

Survival of patients1

Tumor1

Cohort3

Bilateral1

Benefit3

Lung8

Physicians2

RP2R2

Drug9

Cardiac2