Patients with chronic graft versus graft allogeneic stem cell transplantation. Medical search. Frequent questions

Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and methotrexate. (medscimonit.com)
Twenty-three patients experienced acute GVHD and 17 developed chronic GVHD. (medscimonit.com)
Vascular injury has been seen in patients with acute graft versus host disease (GVHD) in the skin. (nih.gov)
We aimed to see whether vascular injury mediated by cytotoxic T lymphocytes and microvessel loss arises in patients with chronic GVHD. (nih.gov)
We investigated eight patients with acute GVHD and ten with chronic GVHD for signs of endothelial injury and microvessel loss by measurement of von Willebrand factor (vWF) in plasma and blood vessel density in biopsy samples taken from lesional skin. (nih.gov)
Controls consisted of nine patients without GVHD who survived for longer than 100 days and nine healthy people. (nih.gov)
Perivascular CD8 T cell infiltrates in skin correlated with vWF plasma concentrations in patients with GVHD (p=0.01), and activated cytotoxic T lymphocytes and endothelial injury were present in these same samples. (nih.gov)
Substantial blood vessel loss may lead to impaired blood perfusion and tissue fibrosis, the hallmark lesion of chronic GVHD. (nih.gov)
Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
The incidence of grade II-IV acute and chronic graft versus host disease (GvHD) was 23.6% and 12.9% respectively. (nih.gov)
Graft-versus-host disease (GVHD) is a complication that occurs following allo-HSCT and is a major driver of posttransplant morbidity and mortality [ 2 ]. (biomedcentral.com)
This article is a summary of the European Society for Blood and Marrow Transplantation (EBMT) webinar entitled 'Pathophysiology of acute and chronic GvHD, novel therapeutic strategies in the preclinical phase' delivered by Ernst Holler on May 5th, 2020. (gvhdhub.com)
The restoration of hematopoiesis together with the donor's immune system can lead to a major immune reaction, graft- versus -host disease (GvHD). (gvhdhub.com)
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
Multivariate analysis shows that HSCT from unrelated donors (P = 0.02) and the development of chronic extensive graft-versus-host disease (GVHD) (P = 0.0004) were the only independent factors associated with AIHA. (elsevierpure.com)
Patients undergoing HSCT from unrelated donors and those who develop chronic extensive GVHD are especially predisposed for this complication. (elsevierpure.com)
which deals with oral problems in the patients after allogeneic hematopoietic stem cell transplantation (HSCT), expecially, short- and long-term dental disorders in children after intensive cytotoxic therapy, and inflammatory/atrophic changes of oral mucosa associated with acute and chronic graft-versus-host disease (GVHD), due to infections and autoaggressive processes. (cttjournal.com)
A long-term experience has generally shown that the results of allogeneic HSCT with cryopreserved graft are comparable to native hematopoietic transplants, in terms of severe acute and chronic GVHD, overall survival, and GVHD-relapse-free survival. (cttjournal.com)
The inclusion of ATG resulted in a significantly lower rate of chronic GVHD after allogeneic transplantation than the rate without ATG. (bmj.com)
The survival rate was similar in the two groups, but the rate of a composite end point of chronic GVHD-free survival and relapse-free survival was higher with ATG. (bmj.com)
The plain English version would read: "In this two year, open-label trial, our company's antihuman T-lymphocyte immune globulin (ATG) halved the rate of chronic graft-versus-host disease (GVHD) in people who had previously undergone allogeneic haematopoietic stem-cell transplantation, but made no difference to mortality. (bmj.com)
The median duration of response, calculated from first response to progression, death, or new systemic therapies for chronic GVHD, was 1.9 months. (yahoo.com)
ORR results were supported by clinically meaningful improvement from baseline in the Lee Symptom Scale (LSS) score, a chronic GVHD symptom measurement, in 52% of patients through Cycle 7 Day 1 of treatment. (yahoo.com)
We are proud to introduce REZUROCK as a new treatment that uniquely addresses the underlying inflammatory and fibrotic pathophysiology of chronic GVHD,' said Harlan W. Waksal, MD, President and CEO of Kadmon. (yahoo.com)
Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants . (medlineplus.gov)
GVHD may occur after a bone marrow, or stem cell, transplant in which someone receives bone marrow tissue or cells from a donor. (medlineplus.gov)
GVHD does not occur when people receive their own cells. (medlineplus.gov)
There are two types of GVHD: acute and chronic. (medlineplus.gov)
Symptoms in both acute and chronic GVHD range from mild to severe. (medlineplus.gov)
Chronic GVHD usually starts more than 3 months after a transplant, and can last a lifetime. (medlineplus.gov)
Many cases of acute or chronic GVHD can be treated successfully. (medlineplus.gov)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)

The airway inflammation of chronic obstructive pulmonary disease (COPD) is largely neutrophilic, but 20-40% of induced sputum samples from individuals with stable COPD have eosinophilic airway inflammation, associated with elevated levels of sputum interleukin (IL)-5. (medscape.com)
Lee works to improve the lives of blood stem cell transplant and bone marrow patients by better understanding the chronic form of graft-versus-host disease. (wikipedia.org)
In particular, she looks to understand and prevent chronic graft-versus-host disease, an autoimmune disorder that occurs after allogeneic hematopoietic stem cell transplantation. (wikipedia.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
KEYTRUDA was also granted accelerated approval in September 2019, and received full approval in July 2021, in combination with LENVIMA ® (lenvatinib) for the treatment of patients with advanced endometrial carcinoma that is not MSI-H or dMMR, who have disease progression following prior systemic therapy in any setting and are not candidates for curative surgery or radiation. (businesswire.com)
While these results are not what we hoped for, we are proud of the foundational role that KEYTRUDA has established in the treatment of certain types of lung cancer, and we are committed to continuing to research how we can further improve responses to our medicines for patients with difficult-to-treat forms of the disease. (streetinsider.com)
AHSCT is a reasonable option for patients with highly active relapsing MS and an inadequate response to the available disease therapies. (bvsalud.org)
The transplantation of stem cells from a healthy donor (allogeneic) offers the chance of cure for patients with an aggressive form of chronic lymphocytic leukemia (CLL), irrespective of genetic prognostic factors and the prior course of the disease. (disabled-world.com)
However, there are patients in whom the disease does not respond to the standard treatment with chemotherapy or antibodies. (disabled-world.com)
Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the GCLLSG CLL3X Trial. (disabled-world.com)
Of possible significance, elevated concentrations of interleukin-6 (IL-6) and neopterin in saliva and serum of patients with the erosive-atrophic form of oral lichen planus suggest they may be involved in the etiology of this disease variation. (medscape.com)
Current data suggest that oral lichen planus (OLP) is a T-cell-mediated autoimmune disease in which autocytotoxic CD8 + T cells trigger the apoptosis of oral epithelial cells. (medscape.com)
Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
Chronic graft- versus -host disease (cGvHD) is a major cause of morbidity after hematopoietic stem cell transplantation (HSCT). (haematologica.org)
As a result, HSCT is often attributed to an increased risk of health complications, the most severe being chronic graft- versus -host disease (cGvHD). (haematologica.org)
Approximately 30-70% of patients who have undergone allogeneic (allo) hematopoietic stem cell transplantation (HSCT) eventually experience chronic graft-versus-host disease (cGVHD). (biomedcentral.com)
Patients who develop steroid-refractory (SR)-cGVHD are the most severely impacted due to significant disease and financial burden. (biomedcentral.com)
Chronic graft-versus-host disease (cGVHD) is a long-term complication of allogeneic hematopoietic stem cell transplantation. (elsevierpure.com)
We use three different medical environments to analyze the mechanisms behind these conditions: systemic sclerosis, pregnancy-related pathologies, and chronic graft versus host disease (cGVHD). (cnrs.fr)
Vulvovaginal chronic graft-versus-host disease with allogeneic hematopoietic stem cell transplantation. (soulsource.com)
ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. (scielo.br)
However, in sickle cell disease (SCD) primarily due to repeated blood transfusions and hemolysis-induced recycling of iron, its supplementation during pregnancy remains questionable and may be harmful. (scielo.br)
Humanigen believes that GM-CSF neutralization with lenzilumab also has the potential to reduce the hyper-inflammatory cascade known as cytokine release syndrome common to chimeric antigen receptor T-cell (CAR-T) therapy and acute Graft versus Host Disease (aGvHD). (businesswire.com)
Transplantation-related issues such as graft versus host disease, graft failure, chronic immunosuppressive therapy, and transplantation-related mortality should be carefully considered prior to proceeding with this approach. (medscape.com)
Impaired Bone Mineral Density in Pediatric Patients with Chronic Graft-versus-Host Disease. (qxmd.com)
Pediatric allogeneic hematopoietic stem cell transplantation (AHSCT) recipients with chronic graft-versus-host disease (cGVHD) are at high risk for endocrinopathies, particularly impaired bone mineral density (BMD). (qxmd.com)
We report 33 patients with cGVHD who were referred to the National Institutes of Health (NIH) for the Natural History of Clinical and Biological Factors Determining Outcomes in Chronic Graft-versus-Host Disease Study (NCT 0092235) and underwent formal BMD assessment via dual-energy X-ray absorptiometry (DEXA). (qxmd.com)
Advances in the management of chronic kidney disease. (qxmd.com)
In the evolving landscape of graft-versus-host disease management, staying abreast of current and projected epidemiological trends is vital. (researchandmarkets.com)
Developed for decision-makers, this Graft vs. Host Disease - Epidemiology Forecast - 2032 report provides a detailed panorama on the incidence and prevalence of this severe complication of allogeneic stem cell transplantation in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. (researchandmarkets.com)
Armed with historical and forecasted data, the report elucidates the severity and organ-specific grading of graft-versus-host disease cases. (researchandmarkets.com)
This comprehensive knowledge is paramount for informed decision-making and strategic planning in the quest to tackle graft-versus-host disease. (researchandmarkets.com)
Graft-versus-host disease is a potentially serious complication of allogeneic stem cell transplantation. (researchandmarkets.com)
Total allogenic transplant cases of graft-versus-host disease in the 7MM range from ~24,440 in 2022 to ~29,600 in 2032. (researchandmarkets.com)
Graft-versus-host disease is categorized into two types: acute and chronic graft-versus-host disease. (researchandmarkets.com)
In the 7MM, the acute graft-versus-host disease incident cases were ~10,340 in 2022, which are likely to increase to ~12,360 by 2032. (researchandmarkets.com)
Furthermore, in the 7MM, the 5-year prevalence of chronic graft-versus-host disease was ~23,080 in 2022, which is likely to increase to ~26,300 cases by 2032. (researchandmarkets.com)
An assessment of the degree of involvement of these organs determines the severity of acute graft-versus-host disease. (researchandmarkets.com)
The overall severity of chronic graft-versus-host disease is classified as mild, moderate, or severe based on organ-specific grading (number of organs and severity). (researchandmarkets.com)
Approximately ~45% of 5-year prevalent cases of chronic graft-versus-host disease belong to the moderate category. (researchandmarkets.com)
Skin (~59%), oral mucosa (~53%), eyes (~53%), lungs (~43%), liver (~29%), joints and fascia (~28%), and gastrointestinal (~23%) are the most often affected organs by chronic graft-versus-host disease. (researchandmarkets.com)
In 2022, the 7MM mortality-adjusted treated acute graft-versus-host disease patients were ~9,830 in first-line, and these cases are expected to increase to ~11,740 cases by 2032. (researchandmarkets.com)
This "Graft vs. Host Disease - Epidemiology Forecast - 2032" report delivers an in-depth understanding of Graft vs. Host Disease, historical and forecasted epidemiology in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan. (researchandmarkets.com)
the disease is a side effect that is common after an allogeneic bone marrow transplant. (researchandmarkets.com)
The two main types of Graft vs. Host Disease are acute Graft vs. Host Disease and Chronic Graft vs. Host Disease. (researchandmarkets.com)
As an allogeneic transplant recipient, the patient might experience either form of Graft vs. Host Disease, either form, or neither. (researchandmarkets.com)
Unexplained chronic liver disease in Ethiopia: a cross-sectional study. (uib.no)
Patients with Treatment-Requiring Chronic Graft versus Host Disease after Allogeneic Stem Cell Transplantation Have Altered Metabolic Profiles due to the Disease and Immunosuppressive Therapy: Potential Implication for Biomarkers. (uib.no)
The aim of this study was to develop a predictive score for moderate-severe chronic graft-versus-host disease (cGVHD) on day +100 after allogeneic stem cell transplantation (HSCT). (unicatt.it)
Covariance pattern models were used to determine predictors of regret over time, including baseline characteristics and post-alloHCT outcomes (acute or chronic graft-versus-host-disease, disease recurrence). (cdc.gov)
The risk of regretting transplantation was 17.5 percentage points (95% confidence interval, 5.5-29.7 percentage points) greater in patients who developed disease recurrence after HCT compared with patients who did not. (cdc.gov)
High incidence of extensive chronic graft-versus-host disease in patients with the REG3A rs7588571 non-GG genotype. (cdc.gov)
Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)
concerns application of Nivolumab in relapsed Hodgkin's disease (HD) following allogeneic HSCT. (cttjournal.com)
302 patients received cisplatin 75 mg/m 2 or carboplatin AUC 5 plus pemetrexed 500 mg/m 2 in 21 day cycles for six cycles or until disease progression or unacceptable toxicity. (bms.com)
Rezurock patient-reported outcomes correlated with clinical response in chronic graft-versus-host disease. (medthority.com)
Results from a pooled analysis of Rezurock (belumosudil) for the treatment of chronic graft-versus-host disease (cGVHD) show certain organ clinical responses correlated with clinically meaningful changes in patient-reported outcomes (PROs). (medthority.com)
These data support use of PROs for response assessment in cGVHD clinical trials and patient care to help capture the patient's perspective on cGVHD disease activity. (medthority.com)
Lung transplantation (LTx) is a life-saving treatment for patients with end-stage lung disease. (researchportal.be)
Background Chronic lung allograft dysfunction (CLAD) and chronic pulmonary graft versus host disease (cGvHD) are life-threatening conditions commonly encountered after lung transplantation and allogeneic hematopoietic stem cell transplantation. (researchportal.be)
OBJECTIVES: - To investigate efficacy of topical clobetasol 0.05% oral rinse for oral chronic graft versus-host disease (cGVHD) ELIGIBILITY: - Patients age 12-99 years with clinically significant oral cGVHD. (getwellsoon.ai)
We remain committed to continued research in melanoma, both to further understand the potential benefit of Yervoy in combination with Opdivo to treat high-risk melanoma patients in the earlier stages of disease, as well as to study additional novel combinations in various settings. (bms.com)
Formerly, negative pressure isolation room, an AIIR is a single-occupancy patient-care room used to isolate persons with a suspected or confirmed airborne infectious disease. (cdc.gov)
NEW YORK, NY / ACCESSWIRE / July 16, 2021 / Kadmon Holdings, Inc. (Nasdaq:KDMN) today announced that the U.S. Food and Drug Administration (FDA) has approved REZUROCK ™ (belumosudil) 200 mg once daily (QD) for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy. (yahoo.com)
This is so important for a chronic disease with a high symptom burden,' said Stephanie Lee, MD, MPH, Professor at the Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, and Research Director of the Long-Term Follow-Up Program at Fred Hutchinson. (yahoo.com)
Data on the impact of chronic Graft-versus-host disease (cGvHD) on cognitive function (CF) and quality of life (QoL) of long-term transplant survivors are sparse. (biomedcentral.com)
The influence of total body irradiation (TBI) as part of the conditioning regimen and chronic graft-versus-host disease (cGvHD) on cognitive function (CF) and quality of life (QoL) of very long-term survivors is still unclear. (biomedcentral.com)
3 After a wave of fascinating reports on the feasibility and efficacy of this "revolutionary" approach, some studies revealed that patients with a high risk of either disease recurrence or non-engraftment did not fare too well with this strategy. (haematologica.org)
8 The pivotal trial testing ATG in the setting of unrelated donors and intensive conditioning suggested a significant reduction in the incidence of chronic graft- versus -host disease without an increase in the risk of relapse. (haematologica.org)
12 Interestingly, ATG reduced the cumulative incidence of acute graft- versus -host disease while it did not affect the rate of chronic graft- versus -host disease. (haematologica.org)
Oral lichen planus (OLP) is a chronic inflammatory disease that causes bilateral white striations, papules, or plaques on the buccal mucosa, tongue, and gingivae. (medscape.com)
Beta-thalassemia (β-thalassemia) or beta-thal, is a genetic disease characterized by anemia, a condition which results from a shortage of healthy red blood cells (RBCs). (bluebirdbio.com)
It is recommended only for younger patients, and its use is limited by a need for matched donors as well as risks of severe complications such as transplant-related mortality, graft rejection, and graft-versus-host disease. (bluebirdbio.com)
Human microsporidiosis is characterized primarily by chronic diarrhea and wasting, with less frequent occurrences of extraintestinal disseminated disease. (cdc.gov)
Videoendoscopy of the upper digestive tract confirmed gastrointestinal graft-versus-host disease, and ultrasound showed splenomegaly with multiple rounded hypodense images in the spleen and liver. (cdc.gov)
Graft-versus-host disease and graft-versus-leukemia responses. (medlineplus.gov)
This disease is characterized by the malfunctioning of the DNA repair mechanism, which present an increase in the rate of spontaneous damage, among these spontaneous chromosomal instability, and hypersensitivity of cells to the chromosomal breaking effect induced by clastogenic agents 2-3 . (bvsalud.org)

Biology of Blood and Marrow Transplantation. (wikipedia.org)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018 8 25 (1): 100-106. (cdc.gov)
69 Years with Acute Myelogenous Leukemia: On Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (cdc.gov)
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2019 6 25 (10): 1975-1983. (cdc.gov)

The potential role of elastin in patients with myeloid leukemia treated with hematopoietic stem cell transplantation (HSCT) has not been investigated so far. (medscimonit.com)
EA and EDPc were increased in patients after HSCT. (medscimonit.com)
Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) in thalassemia remains a challenge. (nih.gov)
In adult patients, the 23-years OS and TFS after HSCT were 70 ± 5% and 67.3 ± 5%, compared to 71.2 ± 5% of OS in CT (P = NS). (nih.gov)
In conclusion, the 30-year survival rate of ex-thalassemia patients after HSCT was similar to that expected in CT thalassemia patients, with the vast majority of HSCT survivors cured from thalassemia. (nih.gov)
Hematopoietic stem cell transplantation (HSCT) is an important therapeutic option for patients with non-malignant diseases as well as high-risk and refractory hematopoietic malignancies. (haematologica.org)
1 HSCT may be followed by chronic inflammation due to tissue self-antigen mismatches among the transplant donor and recipient. (haematologica.org)
3 cGvHD has been estimated to develop in 25% of pediatric and 60% of adult HSCT survivors, may cause chronic and often irreversible organ damage, and has a 10-25% mortality rate. (haematologica.org)
Hematopoietic stem cell transplantation (HSCT) remains an important therapy for long term remission of many malignant and nonmalignant hematological disorders [ 1 , 2 ]. (biomedcentral.com)
An estimated 30-70% of allo-HSCT recipients, who survive more than 100 days after transplantation, develop cGVHD. (biomedcentral.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) involves the infusion of stem cells following administration of high-dose chemotherapy or total body irradiation for either tumor control or to prevent solid transplant rejection. (gvhdhub.com)
Allo-HSCT is an important treatment strategy, which allows administration of myeloablative therapy and the elimination of cancer cells by the transplanted donor T and natural killer (NK) cells in a phenomenon known as the graft- versus -leukemia (GvL) effect. (gvhdhub.com)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
However, owing to the immense heterogeneity of patients' cohorts and progress in HSCT techniques in the last decade, many of reported results failed to be independently validated [ 6 , 8 , 9 ]. (hindawi.com)
Autoimmune hemolytic anemia (AIHA) after allogeneic hematopoietic stem cell transplantation (HSCT) is still not well characterized. (elsevierpure.com)
The aim of this study was to analyze the incidence and risk factors for the development of AIHA, as well as its prognosis and response to treatment in a series of patients undergoing allogeneic HSCT at a single institution. (elsevierpure.com)
Between 1996 and 2004, 272 adult patients with a variety of malignant hematopoietic disorders underwent allogeneic HSCT. (elsevierpure.com)
Twelve patients developed AIHA after HSCT at a median time of 147 days (range, 41-170). (elsevierpure.com)
The authors conclude on good efficiency of haploidentical HSCT for this age group, being comparable to HLA-compatible transplantation. (cttjournal.com)
Total body irradiation (TBI)-based-conditioning before allogeneic hematopoietic stem cell transplantation (allo-HSCT) is standard of care in patients with acute myeloid leukemia (AML) but can cause long-term morbidity. (biomedcentral.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment modality for selected patients with acute myeloid leukemia (AML). (biomedcentral.com)
In this study, we analyzed patient-reported CF and QoL focusing on long-term transplant survivors after 1st allo-HSCT applying a standardized TBI-technique as conditioning regimen. (biomedcentral.com)
We analyzed patient-reported QoL, CF, and symptoms of depression and anxiety in patients with primary or secondary AML who received their 1st allo-HSCT with TBI-based protocols at the Department of Hematology of the University Hospital Regensburg between 1999 and 2017. (biomedcentral.com)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only potentially curative option that is currently available for TDT, but it has serious limitations. (bluebirdbio.com)
Pediatric patients undergoing allogeneic hematologic stem cell transplantation (HSCT) may experience gut-localized or extraintestinal microsporidiosis by Encephalitozoon spp ( 3 ). (cdc.gov)
We present a case of E. bieneusi (genotype D) infection in a child who underwent unrelated allogeneic HSCT in Buenos Aires, Argentina. (cdc.gov)
A 12-year-old boy from Buenos Aires who had a January 2018 diagnosis of intermediate-risk pre-B acute lymphoblastic leukemia received an unrelated allogeneic HSCT in February 2022. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)

In large patient populations, we have shown a CD56 bright natural killer (NK) population to strongly associate with a lack of cGvHD and we hypothesize that these cells function to suppress cGvHD. (haematologica.org)
We aimed to isolate and define the characteristics of regulatory NK (NK reg ) cells associated with suppression of cGvHD. (haematologica.org)
Moreover, this is the first paper to clearly establish that a CD56 bright CD3 - CD16 - perforin- NK reg population associates with a lack of cGvHD and has several unique characteristics, including the suppression of helper T-cell function in vitro. (haematologica.org)
With further investigation we may decipher the mechanism of NK reg suppression and operationalize expansion of NK reg cells associated with cGvHD suppression. (haematologica.org)
2 cGvHD is a multisystemic disorder that occurs due to foreign donor immune cells attacking the recipient's tissues. (haematologica.org)
Various immune-suppressive cell populations appear to associate with suppression of cGvHD, including T reg cells, B reg cells, M2 macrophages, dendritic cells, and CD56 bright natural killer (NK) cells. (haematologica.org)
Ruxolitinib is likely to be cost-effective from Singapore healthcare system's perspective for patients with SR-cGVHD, which is promising in the management of patients with unmet clinical needs. (biomedcentral.com)
We retrospectively reviewed the data of 120 consecutive patients who received systemic steroid therapy for cGVHD between January 2007 and December 2018 at three institutions. (elsevierpure.com)
Among patients with steroid-responsive cGVHD, those who successfully tapered off corticosteroids within 1 year were defined as the early withdrawal group (EW-cGVHD) and others were defined as the dependent group (Dp-cGVHD). (elsevierpure.com)
Twenty-six patients were classified as EW-cGVHD and 55 as Dp-cGVHD. (elsevierpure.com)
The 5-year overall survival and cGVHD recurrence-free survival rates were significantly higher in EW-cGVHD than Dp-cGVHD (96% vs. 68%, p = 0.017 and 84% vs. 41%, p = 0.002, respectively). (elsevierpure.com)
They occur on a systemic level in systemic sclerosis, they are localized in pregnancy-related diseases and they are induced by an external graft in cGVHD. (cnrs.fr)
Although we expected the rate to be higher than that observed for pediatric AHSCT recipients in studies that did not analyze patients with cGVHD separately, this rate is nonetheless extremely high. (qxmd.com)
Our study, although limited by small patient numbers and lack of a control AHSCT recipient group without cGVHD, indicates that children with cGVHD are at a greater risk for BMD impairment than previously appreciated. (qxmd.com)
In addition, given the high risk of BMD impairment in pediatric AHSCT recipients with cGVHD, such patients should undergo BMD evaluation upon developing cGVHD, with continued monitoring thereafter to allow intervention before progression of the BMD impairment to its severe manifestation, VCF. (qxmd.com)
We studied 1292 patients allografted between 1990 and 2016, alive on day +100 after transplant, without cGVHD, and with full biochemistry laboratory values available. (unicatt.it)
In conclusion, Day100 score predicts cGVHD, TRM, and survival and, if validated in a separate group of patients, could be considered for trials of preemptive therapy. (unicatt.it)
cGVHD is a complication that can occur following allogeneic stem cell transplantation, resulting in significant morbidity and mortality. (medthority.com)
Approximately 14,000 patients in the United States are living with cGVHD. (medthority.com)
REZUROCK represents a new treatment paradigm for thousands of cGVHD patients, including those with difficult-to-treat manifestations like fibrosis,' said Corey Cutler, MD, MPH, FRCPC, Associate Professor of Medicine at Harvard Medical School and Medical Director, Adult Stem Cell Transplantation Program at the Dana-Farber Cancer Institute. (yahoo.com)
REZUROCK has shown robust and durable responses across the spectrum of cGVHD and is safe and well tolerated, allowing patients to stay on therapy and achieve meaningful benefit from treatment. (yahoo.com)
The FDA approval of REZUROCK is based on safety and efficacy results from ROCKstar (KD025-213), a randomized, open-label, multicenter pivotal trial of REZUROCK in patients with cGVHD who had received two to five prior lines of systemic therapy. (yahoo.com)
The median time from cGVHD diagnosis was 25.3 months and 48% of patients had four or more organs involved. (yahoo.com)
Patients receiving REZUROCK reported significant improvements in cGVHD symptoms, showing that not only did treatment result in organ responses, but it also made people feel better. (yahoo.com)
REZUROCK has been well tolerated and adverse events have been consistent with those expected in patients with advanced cGVHD receiving corticosteroids and/or other immunosuppressants. (yahoo.com)
Eleven patients (34.4%) had active cGvHD, 11 (34.4%) resolved cGvHD and 10 (31.3%) never had cGvHD. (biomedcentral.com)
Patients with active cGvHD had poorer FACT-BMT, FACT-Cog and higher PHQ-4 scores compared to patients with resolved cGvHD or who never had cGvHD. (biomedcentral.com)
Outcomes were similar in patients with resolved cGvHD and those who never had cGvHD. (biomedcentral.com)
Patients with active cGvHD had similar FACT-Cog, but lower FACT-BMT in comparison to normative data. (biomedcentral.com)

The incidence of grade 2/3 bacterial or grade 3 fungal infections 100 days following transplant was 39% with omidubicel, vs 60% with standard transplants. (medscape.com)
Abbey Jenkins, president and CEO of Gamida, called the approval "a major advancement in the treatment of patients with hematologic malignancies that we believe may increase access to stem cell transplant and help improve patient outcomes. (medscape.com)
Transplant Cell Ther 2021. (harvard.edu)
[ 14 ] The first successful allogeneic stem cell transplant from an HLA-identical sibling donor was reported in 1982. (medscape.com)
Before undergoing an allogeneic stem cell transplant, the patient will receive high doses of chemotherapy or radiation to destroy the diseased cells and prepare the body for the donor cells. (researchandmarkets.com)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)
Kadmon, a Sanofi Company, will present the results at the 2022 American Society for Transplantation and Cellular Therapy (ASTCT) and the Center for International Blood & Marrow Transplant Research (CIBMTR) Tandem Meetings in Salt Lake City, Utah. (medthority.com)
The final objective remains to increase the quality and survival of the lung transplant patient. (researchportal.be)
Survival after LTx is limited due to development of chronic rejection of the transplant lungs, also termed chronic lung allograft dysfunction (CLAD), affecting 50% of patients within 5 years. (researchportal.be)
The project integrates clinical data and advanced molecular profiling of patients newly transplanted at major European kidney transplant centers. (researchportal.be)
Instruments included the Functional Assessment of Cancer Therapy-Bone marrow transplant (FACT-BMT, version 4), the FACT-Cognition Function (FACT-Cog, version 3) and the Patient Health Questionaire-4 (PHQ-4). (biomedcentral.com)
We report a case of Enterocytozoon bieneusi infection in a pediatric hematopoietic stem cell transplant recipient in Argentina. (cdc.gov)
The most identified species of Microsporidia in humans are Enterocytozoon bieneusi and Encephalitozoon intestinalis , which have emerged as opportunistic pathogens in immunosuppressed persons, such as those infected with HIV, organ transplant recipients, and cancer patients. (cdc.gov)
This type of transplant is called allogeneic. (medlineplus.gov)
Before a transplant, tissue and cells from possible donors are checked to see how closely they match the recipient. (medlineplus.gov)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation. (cdc.gov)

Vascular endothelial cells form the interface between recipient tissues and circulating alloreactive donor T cells after allogeneic stem cell transplantation. (nih.gov)
Host endothelial cells are a target of alloreactive donor cytotoxic T lymphocytes. (nih.gov)
Omidubicel is made from umbilical cord donor stem cells that are processed with nicotinamide, a form of vitamin B3, to enhance and expand the number of progenitor cells, the product's maker, Israel-based Gamida Cell, explained in a press announcement . (medscape.com)
Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
The main risk still remains the "graft-versus-host reaction", in which donor cells attack the patient's own cells, which are foreign to them. (disabled-world.com)
It is crucial to control the transplanted donor immune cells so that the effect is strong enough to eliminate the leukemia cells but not strong enough to lead to complications in other tissues and organs. (disabled-world.com)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
The graft usually comes from a human leukocyte antigen (HLA)-matched donor and contains hematopoietic cells as well as immune cells, including T lymphocytes. (gvhdhub.com)
Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil. (cdc.gov)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Because only one fourth of patients have such a sibling donor, mismatched related or matched unrelated donors (identified through international registries) are often used. (msdmanuals.com)

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
We have seen few advances over the last three decades that have improved historically poor survival outcomes for patients with esophageal cancer," said Professor Antoine Adenis, Department of Medical Oncology, Montpellier Cancer Institute, France. (merck.com)
Lenzilumab binds to and neutralizes GM-CSF, potentially improving outcomes for patients hospitalized with COVID-19. (businesswire.com)
Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life. (cdc.gov)
Histology is a well-established prognostic factor in mesothelioma, with non-epithelioid patients generally experiencing poorer outcomes. (bms.com)
What matters to you as a clinician is the downstream value of the test-how it will help your management and improve the outcomes of patients. (bmj.com)
Rezurock patient-reported outcomes correlated with. (medthority.com)

Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)

In CAR-T, lenzilumab successfully achieved the pre-specified primary endpoint at the recommended dose in a Phase 1b study with Yescarta® in which the overall response rate was 100% and no patient experienced severe cytokine release syndrome or severe neurotoxicity. (businesswire.com)
Patient activity may be limited secondary to severe anemia. (medscape.com)
Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
In the most severe form of beta-thal, also referred to as transfusion dependent thalassemia (TDT), patients require lifelong regular red blood cell transfusions to survive. (bluebirdbio.com)
To treat chronic anemia, the hallmark symptom of severe beta-thal, patients currently depend on regular blood transfusions-as often as every 3-4 weeks. (bluebirdbio.com)

Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)

Moreover, recognizing the significant mortality rate, the report also presents insights on the number of living patients receiving or eligible for treatment. (researchandmarkets.com)
The mortality-adjusted treatment rate is used to estimate the number of living patients who are receiving treatment or who will be eligible for treatment. (researchandmarkets.com)
Chronic lung allograft dysfunction (CLAD), the clinical correlate of chronic rejection, is the principal cause of late morbidity, mortality and excessive health-care costs following lung transplantation. (researchportal.be)
Cardiovascular and metabolic morbidity and mortality following liver transplantation are a major problem. (researchportal.be)

In aggregate, the available data suggest autologous hematopoietic stem cell transplantation (AHSCT) has potent, durable efficacy to treat relapsing multiple sclerosis (MS). Safety issues and financial costs are significant but largely associated with the procedure itself. (bvsalud.org)
The means of the allogeneic group were lower than those of the autologous group in all domains, showing a significant difference in relation to additional concerns (p=0.01) and in the treatment evaluation index (p=0.04). (bvsalud.org)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)

KEYTRUDA plus chemotherapy is the first anti-PD1 therapy approved in Europe in this first-line setting, allowing these patients to be treated with immunotherapy earlier in the course of their treatment," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
As a leader in lung cancer research, we continue to try to advance science for our patients by building upon the standard we set several years ago with KEYTRUDA," said Dr. Gregory Lubiniecki, Vice President, Global Clinical Development, Merck Research Laboratories. (streetinsider.com)
The German CLL Study Group proved this in a multi-centric clinical phase II study led by Professor Dr. Peter Dreger, senior consultant and head of the division of stem cell transplantation at the Department of Internal Medicine V at Heidelberg University Hospital. (disabled-world.com)
Oral lichen planus (OLP) is a chronic mucocutaneous disorder that presents in a wide range of clinical forms, such as unilateral or bilateral white striations, papules, or plaques on the buccal mucosa, labial mucosa, tongue, and gingiva. (medscape.com)
These methods and results can help us to better understand immune reconstitution following hematopoietic cell transplantation, leading to future studies on the clinical application of adoptive T-cell therapies. (nature.com)
A better and deeper understanding of immune reconstitution following allo-HCT is required for further clinical application of these adoptive T-cell therapies. (nature.com)
Appropriate clinical protocols for children and adolescents using non-manipulated hematopoietic grafts, and evaluation of medium- and long-term results are reported by Dr. O. Paina et al. (cttjournal.com)
Most patients exhibited appreciable clinical response, thus confirming efficiency of this drug in HD. (cttjournal.com)
The case is quite instructive to oncohematologists since it compares clinical course, cytogenetic and molecular evolution in the patient. (cttjournal.com)
This issue also contains a concise comment by Professor Axel R. Zander, who presents the available clinical criteria for risk prediction in AML patients that was vividly discussed in two previous CTT journals. (cttjournal.com)
PRINCETON, N.J.--(BUSINESS WIRE)-- Bristol Myers Squibb (NYSE: BMY) today announced that Opdivo ® (nivolumab) plus Yervoy ® (ipilimumab) demonstrated a significant improvement in overall survival (OS) in patients with previously untreated, unresectable malignant pleural mesothelioma (MPM) in the Phase 3 CheckMate -743 clinical trial. (bms.com)
These data in malignant pleural mesothelioma follow on the established long-term efficacy of Opdivo plus Yervoy in patients with non-small cell lung cancer and further demonstrate the combination's potential to change survival expectations in thoracic cancers," said Sabine Maier, Vice President, Oncology Clinical Development, Bristol Myers Squibb. (bms.com)
In a study reported in the Journal of Clinical Oncology, Phillips et al found that immune-related cutaneous adverse events in patients receiving immune checkpoint inhibitors generally responded to symptom- and phenotype-directed dermatologic therapies, and that biologic therapies were effective in. (ascopost.com)
The pooled analysis of the ROCKstar (KD025-213) and KD025-208 studies demonstrates a very strong, but not universal, correlation between organ clinical response measures and clinically meaningful changes in PROs in patients treated with Rezurock. (medthority.com)
We designed this study to determine if dual immunotherapy has the potential to bring additional benefits to patients in this setting, understanding the high benchmark we would need to exceed with this trial," said Sabine Maier, M.D., vice president, Head of Oncology Clinical Development, Bristol Myers Squibb. (bms.com)
Bristol Myers Squibb thanks the patients and investigators who were involved in the CheckMate -915 clinical trial. (bms.com)
Monitor patients closely for symptoms and signs that may be clinical manifestations of underlying immune-mediated adverse reactions. (keytrudahcp.com)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)

Functionality of HSV-TK gene expressing T-cells was shown by loss of bcr-able gene expression as well as by control of cytomegalovirus-reactivation. (frontiersin.org)
Cytomegalovirus reactivation is still a critical concern following allogeneic hematopoietic cell transplantation, and cellular immune reconstitution of cytomegalovirus-specific cytotoxic T-cells is necessary for the long-term control of cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation. (nature.com)

Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. (scielo.br)
3 The study began in October 2020 and was comprised of hospitalized patients who need medical care for COVID-19 pneumonia and randomized (1:1) to the treatment groups. (businesswire.com)

Lee is the Director of the Fred Hutchinson Cancer Research Center Long-Term Follow-Up (LTFU) program, which tracks over 5,000 patients who have undergone bone marrow or stem cell transplants. (wikipedia.org)
What are some common complaints after a patient has undergone lung surgery? (podbean.com)

Conclusions: Among patients who underwent alloHCT and lived to 100 days, the majority did not report regretting their transplantation. (cdc.gov)

Lee studies bone marrow and stem cell transplantation, and ways to prevent complications during transplants. (wikipedia.org)
Para la recolección de datos, se utilizaron los cuestionarios Functional Assessment Cancer Therapy Bone Marrow Transplantation y el COmprehensive Score for financial Toxicity. (bvsalud.org)
For data collection, the Functional Assessment Cancer Therapy Bone Marrow Transplantation and COmprehensive Score for Financial Toxicity questionnaires were used. (bvsalud.org)
Para coleta de dados, utilizaram-se os questionários Functional Assessment Cancer Therapy Bone Marrow Transplantation e COmprehensive Score for financial Toxicity. (bvsalud.org)
Bone Marrow Transplantation , 39 (9), 555-561. (elsevierpure.com)
Source of stem cells were peripheral blood, bone marrow or cord blood. (biomedcentral.com)
People who receive closely matched bone marrow tissue and cells usually do better. (medlineplus.gov)
Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
Some of these diseases develop mainly after bone marrow transplantation. (bvsalud.org)
An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)

The European Commission's approval of KEYTRUDA plus chemotherapy for the treatment of certain patients with esophageal and HER2-negative GEJ cancer provides a new option in the first-line setting that has shown significant improvements in progression-free and overall survival. (merck.com)
Positive data from LIVE-AIR demonstrated lenzilumab improved the likelihood of survival without the need for mechanical ventilation in hospitalized COVID-19 patients (HR=1.54, p=0.040). (businesswire.com)
[ 16 ] This group's research documented a 90% long-term survival rate in patients with favorable characteristics (young age, HLA match, no organ dysfunction). (medscape.com)
For more than 15 years, no new systemic treatment options that can extend survival have been approved for patients with malignant pleural mesothelioma. (bms.com)
While chronic transfusions are critical for patients' survival, they are associated with serious challenges. (bluebirdbio.com)

CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)

The incidence of pneumonitis is higher in patients who have received prior thoracic radiation. (keytrudahcp.com)
The incidence of new or worsening hypothyroidism was higher in 389 adult patients with cHL (17%) receiving KEYTRUDA as a single agent, including Grade 1 (6.2%) and Grade 2 (10.8%) hypothyroidism. (keytrudahcp.com)

AIHA was never the primary cause of death but added morbidity in patients with other concomitant complications. (elsevierpure.com)

The dense subepithelial mononuclear infiltrate in oral lichen planus is composed of T cells and macrophages, and there are increased numbers of intraepithelial T cells. (medscape.com)
We observed that IL-1β-activated microvascular endothelial cells from SSc patients induce monocytes to differentiate into DC-SIGN+-, alternatively activated macrophages producing high levels of CCL18, CCL2 and CXCL8, but no IL-10. (cnrs.fr)
In the skin of SSc patients, DC-SIGN+ macrophages are enriched in the perivascular region and their numbers correlate to skin fibrosis. (cnrs.fr)
Our ongoing and future studies aim to characterize immune functions of endothelial cell-induced DC-SIGN+ alternatively activated macrophages and to test whether DC-SIGN targeting could alter these functions both in vitro and in mouse models of SSc. (cnrs.fr)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)

The FDA's "approval is an important advance in cell therapy treatment in patients with blood cancers. (medscape.com)
Cite this: FDA OKs Stem Cell Therapy to Reduce Infection Risk in Blood Cancer Patients - Medscape - Apr 18, 2023. (medscape.com)
KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
MRK ), known as MSD outside of the United States and Canada, and Eisai today provided updates on two Phase 3 trials, LEAP-006 and LEAP-008, evaluating KEYTRUDA, Merck's anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, in patients with certain types of metastatic non-small cell lung cancer. (streetinsider.com)
Successful treatment of therapy-resistant chronic leukemia using allogeneic stem cell transplantation. (disabled-world.com)
Our study is the largest so far for this patient population and proved that allogeneic stem cell transplantation is a promising therapy option for high-risk CLL and has the potential to cure for this otherwise incurable kind of leukemia," says Professor Dreger, head of the study. (disabled-world.com)
Allogeneic stem cell transplantation is a very stressful and risky form of therapy, which could previously not be carried out on the generally older patients affected by CLL. (disabled-world.com)
Vaginal Dilator Therapy: A Guide for Providers for Assessing Readiness and Supporting Patients Through the Process Successfully. (soulsource.com)
Patients receiving long-term transfusion therapy also require iron chelation. (medscape.com)
Mario E. Lacouture, MD, of Memorial Sloan Kettering Cancer Center, discusses the effect on patients of dermatologic toxicities associated with targeted therapies: their psychosocial impact, financial burden, physiological pain, and potential to alter therapy. (ascopost.com)
Patients enrolled in the trial had no prior systemic anti-cancer treatment for melanoma, except surgery for the melanoma lesion(s) and/or adjuvant radiation therapy after neurosurgical resection for central nervous system lesions. (bms.com)
Patients had cycled through a median of 3 prior lines of systemic therapy and 78% were refractory to their last therapy. (yahoo.com)
This means that the treatment itself can cause serious complications - including progressive multi-organ damage and organ failure - and requires chronic treatment with chelation therapy to remove iron. (bluebirdbio.com)
Transfusions and iron chelation therapy only provide temporary relief, and despite intense treatment regimens patients may still experience a wide range of symptoms, including fatigue and weakness to heart failure, diabetes or organ malfunction. (bluebirdbio.com)
Effect of anticoagulant/antifibrinolytic combination therapy on enhanced-fibrinolytic-type DIC in end-of-life stage solid tumor patients. (kanazawa-u.ac.jp)
Possibility of PMX-DHP therapy as a principal strategy against cytokine storm in COVID-19 - Insights from reconstructed coagulation data. (kanazawa-u.ac.jp)
Consider administration of other systemic immunosuppressants in patients whose adverse reactions are not controlled with corticosteroid therapy. (keytrudahcp.com)

All patients visited the Department of Hematology of the University Hospital Regensburg for routine follow-up visits. (biomedcentral.com)

At the study's final analysis, there was not an improvement in OS for patients treated with KEYTRUDA plus LENVIMA with chemotherapy compared to KEYTRUDA with chemotherapy. (streetinsider.com)
For conditioning for transplantation, patients were given a reduced dosage of chemotherapy so that the acute tolerance of the transplantation was very good. (disabled-world.com)
At two years, 41% of patients treated with the Opdivo plus Yervoy combination were alive, compared to 27% of patients treated with chemotherapy. (bms.com)
CheckMate -743 is an open-label, multi-center, randomized Phase 3 trial evaluating Opdivo plus Yervoy compared to chemotherapy (pemetrexed and cisplatin or carboplatin) in patients with previously untreated malignant pleural mesothelioma (n=605). (bms.com)
KEYTRUDA is indicated for the treatment of patients with high-risk early-stage triple-negative breast cancer (TNBC) in combination with chemotherapy as neoadjuvant treatment, and then continued as a single agent as adjuvant treatment after surgery. (keytrudahcp.com)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)

KEYTRUDA is approved for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (businesswire.com)
Objective: to evaluate and correlate the quality of life and financial toxicity of adult patients undergoing hematopoietic stem cell transplantation during the COVID-19 pandemic. (bvsalud.org)
22] Oral lichen planus is a common noninfectious oral mucosal disorder among adult patients who attend oral pathology and oral medicine clinics. (medscape.com)
Pneumonitis rates for adult patients with cHL were similar in patients with and without prior thoracic radiation. (keytrudahcp.com)
Adult patients with cHL who developed pneumonitis received high-dose corticosteroids for a median duration of 10 days (range: 2 days-53 months). (keytrudahcp.com)
Adult patients with resected NSCLC who were treated with KEYTRUDA as adjuvant monotherapy and developed pneumonitis received high-dose corticosteroids for a median duration of 10 days (range: 1 day to 2.3 months). (keytrudahcp.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)

Eosinophilia and pulmonary infiltrates have been reported in patients with AIDS, lymphoma, a variety of inflammatory lung diseases, and collagen vascular diseases (see Etiology ). (medscape.com)
Which patient should not undergo surgery for lung cancer? (podbean.com)
How many days do patients spend in the hospital with various types of lung surgery? (podbean.com)
Translational research on chronic rejection after lung transplantation: towards better treatment in patients. (researchportal.be)
My BOF−ZAP project is part of the BREATHE research group and includes research into rejection after lung transplantation focusing on structural changes of the lung and the allo-immune response. (researchportal.be)
This research ranges from basic experimental research in cell cultures and laboratory animals to translation to the human lung and the patient. (researchportal.be)

Gastrointestinal toxicities were the most frequent (97.1%) and all patients received antineoplastic/chemotherapeutic and antiemetic treatment. (bvsalud.org)

This accelerated approval was based on efficacy data from patients enrolled in one of five open-label, multi-cohort trials, including KEYNOTE-158. (businesswire.com)
The efficacy and safety of caplacizumab in Japanese patients with immune-mediated thrombotic thrombocytopenic purpura: an open-label phase 2/3 study. (kanazawa-u.ac.jp)

One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)

The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)

Adverse events are consistent with allogeneic hematopoietic stem cell transplantation . (medscape.com)

Affected patients are usually middle-aged, are nonatopic, and have no history of smoking. (medscape.com)

KEYTRUDA plus LENVIMA is approved in the U.S., the EU, Japan and other countries for the treatment of advanced renal cell carcinoma (RCC) and certain types of advanced endometrial carcinoma. (streetinsider.com)
Imoxin attenuates high fructose induced oxidative stress and apoptosis in renal epithelial cell via downregulation of PKR Pathway. (uib.no)

It is estimated approximately 5-15% of colorectal cancer patients have tumors that score as either MSI-H or dMMR when testing is performed. (merck.com)

The diagnoses were acute myeloid leukemia (AML, n=25) and chronic myeloid leukemia (CML, n=15). (medscimonit.com)
Intermediate doses of unfractionated TBI have been successfully used by other colleagues in diseases such as chronic myeloid leukemia. (haematologica.org)

The safety and effectiveness of KEYTRUDA in pediatric patients with MSI-H central nervous system cancers have not been established. (businesswire.com)
The safety and effectiveness of KEYTRUDA as a single agent have been established in pediatric patients with melanoma, cHL, PMBCL, and MSI⁠-⁠H or dMMR cancer. (keytrudahcp.com)
Use of KEYTRUDA in pediatric patients for these indications is supported by evidence from adequate and well-controlled studies in adults with additional pharmacokinetic and safety data in pediatric patients. (keytrudahcp.com)
In KEYNOTE⁠-⁠051, 173 pediatric patients (65 pediatric patients aged 6 months to younger than 12 years and 108 pediatric patients aged 12 years to 17 years) were administered KEYTRUDA 2 mg/kg every 3 weeks. (keytrudahcp.com)

Here we show the features of repertoire diversity and the gene expression profile of HLA-A24 cytomegalovirus-specific cytotoxic T-cells in actual recipients according to the cytomegalovirus reactivation pattern. (nature.com)

The US Food and Drug Administration (FDA) approved omidubicel-onlv (Omisirge) for reducing infections and hastening neutrophil recovery for blood cancer patients aged 12 years and older who are undergoing allogeneic umbilical cord blood stem cell transplants. (medscape.com)
The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)

Conclusion: The current study shows iron sufficiency in most cases of pregnancy with SCA and suggests that evaluation of iron status must be made before initiating iron prophylaxis in pregnant women with SCA, especially in regions having a high prevalence of sickle cell hemoglobinopathy. (scielo.br)

We thank all the patients, their families and the investigators involved. (streetinsider.com)
Investigators at 16 different treatment centers in Germany included a total of 90 patients with high-risk CLL in the current study. (disabled-world.com)
The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)

It can attack many different organs, and the treatment involves the use of immunosuppressive medications, rendering patients immunocompromised. (wikipedia.org)
KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. (merck.com)
KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
Patients with thalassemia minor usually do not require any specific treatment. (medscape.com)
In 2014, 382 patients with confirmed EVD were admitted to the Ebola treatment centre in Foya, Liberia. (bmj.com)
Additional treatment options are also chronic and still require regular transfusion and chelation. (bluebirdbio.com)
Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment. (who.int)
Note: subjects with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface (HBs) antigen negative-, anti-HBs antibody positive and anti-hepatitis B core (HBc) antibody negative) or positive anti-HBc antibody from intravenous immunoglobulins (IVIG) or patients who have past exposure to HepB (HepB Surface Antigen negative but core antibody positive and DNA negative) who do not require treatment may participate. (who.int)

Determination of prognostic factors for vaginal mucosal toxicity associated with intravaginal high-dose rate brachytherapy in patients with endometrial cancer. (soulsource.com)

Conclusion: Patients diagnosed with SCD who reported perception of prejudice had statistically significant worse QoL, revealing the negative impact, that might lead to sadness and social isolation. (scielo.br)
They have each brought significant benefit as monotherapies for appropriate melanoma patients in the adjuvant setting, and as a dual immunotherapy regimen in the metastatic setting. (bms.com)
Thank you to the patients, their families and caregivers, who are the center of our focus in achieving this significant milestone. (yahoo.com)

Anatomy29

Organisms10

Diseases50

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Psychiatry and Psychology2

Phenomena and Processes29

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science4

Named Groups5

Health Care24

Geographicals1

GVHD41

Disease82

Blood and Marrow Transplantation4

HSCT39

CGvHD29

Transplant16

Haematopoietic stem cell transplant1

Donor13

Outcomes10

20181

Severe5

Curative3

Mortality4

Autologous5

Clinical18

Control of cytomegalovirus-reactivation2

20202

Undergone2

Underwent1

Bone10

Survival5

AGvHD1

Incidence2

Morbidity1

Macrophages5

Therapy18

Hematology1

Chemotherapy6

Adult7

Lung6

Gastrointestinal1

Efficacy2

Immune cells1

Autoimmune1

Adverse1

Middle-aged1

Renal2

Tumors1

Myeloid leukemia2

Pediatric patients4

Recipients1

Umbilical2

Prevalence1

Investigators3

Treatment8

Toxicity1

Significant3