Patients with adenocarcinoma. Medical search. Frequent questions

The Canadian Task Force on Preventive Health Care recommends not screening adults with chronic gastroesophageal reflux disease (GERD) for esophageal adenocarcinoma and precursor conditions (Barrett esophagus or dysplasia), because there is an absence of evidence for benefit, and there are uncertain harms, important resource implications and variable patient values and preferences. (cmaj.ca)
A single retrospective cohort study (very low-certainty evidence) found that screening patients with chronic GERD identified more cases with esophageal adenocarcinoma at an early stage, but found no difference in long-term survival (all-cause mortality). (cmaj.ca)
WEDNESDAY, Sept. 20, 2023 -- Patients with nonerosive gastroesophageal reflux disease (GERD) do not have an increased risk for esophageal adenocarcinoma compared with the general population, according to a study published online Sept. 13 in The. (medworm.com)
MedPage Today) -- Patients with non-erosive gastroesophageal reflux disease (GERD) appear to have a similar incidence of esophageal adenocarcinoma as the general population, according to a large Nordic population-based cohort study with up to. (medworm.com)
Necropsy revealed a disseminated esophageal adenocarcinoma. (cdc.gov)
Gastroesophageal reflux disease (GERD) can increase risk of esophageal adenocarcinoma, increase need for medication, negatively impact quality of life (QOL) and is among the most common conditions in World Trade Center (WTC) first responders. (cdc.gov)
WEDNESDAY, Sept. 20, 2023 (HealthDay News) -- Patients with nonerosive gastroesophageal reflux disease (GERD) do not have an increased risk for esophageal adenocarcinoma compared with the general population, according to a study published online Sept. 13 in The BMJ . (msdmanuals.com)
Dag Holmberg, M.D., Ph.D., from Karolinska Institutet in Stockholm, and colleagues conducted a population-based cohort study to examine the incidence rate of esophageal adenocarcinoma among patients with nonerosive GERD versus the general population. (msdmanuals.com)

Wei LL, Zhang ST, Liao Y, Zhang Y, Yu Y, Mi N. Factors influencing spiritual wellbeing among pancreatic ductal adenocarcinoma patients receiving chemotherapy. (wjgnet.com)
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with 1 and 5-year survival rates of ~18% and 7% respectively. (nih.gov)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest human malignancies, with a 5-year survival rate of only 5% and a median survival of less than 6 months[ 1 ]. (oncotarget.com)
Laparoscopic pancreaticoduodenectomy for ductal adenocarcinoma of common bileduct: A case report and literature review. (medscimonit.com)
We present a case of a 65-year-old man with pancreatic ductal adenocarcinoma who received renally modified FOLFIRINOX every 14 days at doses of oxaliplatin 42.5 mg/m 2 , irinotecan 90 mg/m 2 , and leucovorin 400 mg/m 2 given intravenously on day 1, and fluorouracil 2400 mg/m 2 given via continuous infusion over 46 hours. (jhoponline.com)
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. (tmu.edu.tw)
Background: The prevalence of different periampullary cancers (pancreatic ductal adenocarcinoma, distal cholangiocarcinoma, ampullary cancer and duodenal cancer) is heterogeneous in the literature. (lu.se)
Results: Among non-curative patients, 3704 (83.6 per cent) were diagnosed with pancreatic ductal adenocarcinoma. (lu.se)
Among patients treated with pancreatoduodenectomy, diagnosis was pancreatic ductal adenocarcinoma in 1380 (50.0 per cent), distal cholangiocarcinoma in 284 (10.3 per cent), ampullary cancer in 376 (13.6 per cent), duodenal cancer in 160 (5.8 per cent) and other diagnoses in 560 (20.3 per cent) patients. (lu.se)
The preoperative diagnosis corresponded to the postoperative in 1177 (67.5 per cent) patients for pancreatic ductal adenocarcinoma, 162 (37.4 per cent) patients for distal cholangiocarcinoma, 220 (61.3 per cent) patients for ampullary cancer and 120 (53.6 per cent) patients for duodenal cancer. (lu.se)
A higher rate of pancreatic ductal adenocarcinoma was seen in surgical specimens who underwent standardized evaluation, from 56.8 per cent to 64.3 per cent (P = 0.003). (lu.se)
Conclusion: The proportion of pancreatic ductal adenocarcinoma was higher in patients in a non-curative setting compared with patients who underwent surgery. (lu.se)
Standardized evaluation of the surgical specimen has increased pancreatic ductal adenocarcinoma, R1 and N1 rates. (lu.se)
Purpose Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. (medscape.com)
Pancreaticoduodenectomy Among Patients With Pancreatic Ductal Adenocarcinoma. (cancercentrum.se)
Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe. (cancercentrum.se)

Arrington AK, Nelson R, Patel SS, Luu C, Ko M, Garcia-Aguilar J, Kim J. Timing of chemotherapy and survival in patients with resectable gastric adenocarcinoma. (wjgnet.com)
Chemotherapy-naïve patients with advanced PDAC were eligible for the study. (nih.gov)
The efficacy and benefit of second-line chemotherapy in advanced pancreatic adenocarcinoma has never been demonstrated although it is regularly used. (nih.gov)
The results of this trial bring arguments to support a modest value of second-line chemotherapy for advanced pancreatic adenocarcinoma. (nih.gov)
Treatment with docetaxel + nintedanib may be appropriate post-durvalumab in refractory patients or following progression to first-line chemotherapy + immunotherapy, or second-line chemotherapy after first-line immunotherapy, or first-line chemotherapy in some patients with low/negative PD-L1 expression, or second-line immunotherapy after first-line chemotherapy. (gencat.cat)
A randomized clinical trial REGATTA which aimed to evaluate whether the addition of gastrectomy to chemotherapy improves survival for advanced gastric cancer patients with a single non-curable factor was terminated ahead of time due to the negative results from the interim analysis [ 2 ]. (biomedcentral.com)
The aim of this study was to evaluate the clinical efficacy and safety of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy. (elsevierpure.com)
Less than 20 % of patients with resectable oesophageal adenocarcinoma obtain a pathological response following neoadjuvant chemotherapy. (rcsi.com)
Tumours from 144 patients treated with platinum-based neoadjuvant chemotherapy followed by surgical resection were assembled into tissue microarrays prior to immunohistochemical analysis. (rcsi.com)
The combination of these markers is an independent indicator of outcome in neoadjuvant chemotherapy treated oesophageal adenocarcinoma. (rcsi.com)
The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adult patients with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction adenocarcinoma. (ajmc.com)
The FDA has approved pembrolizumab (Keytruda) in combination with fluoropyrimidine- and platinum-containing chemotherapy for the first-line treatment of adults with locally advanced unresectable or metastatic, HER2-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma. (ajmc.com)
Patients were defined as having received chemotherapy (CTX), chemoradiation (CRT), or observation (OBS). (ices.on.ca)
But this modality is reserved for patients who can tolerate this multicomponent chemotherapy regimen and may be limited in patients with significant comorbidities, including renal insufficiency. (jhoponline.com)
The patient received 3 cycles of chemotherapy and declined further treatment because of intolerable associated adverse events (including nausea, diarrhea, and fatigue). (jhoponline.com)
The use of chemotherapy in patients with cancer and renal impairment, especially in those with end-stage renal disease (ESRD), presents clinicians with multiple issues to consider. (jhoponline.com)
7 A careful review of the literature and an evaluation of each agent's pharmacokinetics should be performed before the administration of chemotherapy in patients with ESRD. (jhoponline.com)

Irinotecan hydrochloride is under development for the treatment of small cell lung cancer (SCLC), triple-negative breast cancer (TNBC), pancreatic cancer, metastatic adenocarcinoma of biliary tract, including intrahepatic cholangiocarcinoma (IHCC), extrahepatic cholangiocarcinoma (EHCC) and gallbladder carcinoma, HER2 negative breast cancer and metastatic adenocarcinoma of the pancreas. (pharmaceutical-technology.com)
Abstract Background The prognosis of patients with pancreatic cancer remains poor and novel therapeutic targets are required urgently. (hal.science)
Conclusion In patients with resected left-sided pancreatic cancer, a tumour microenvironment characterized by a high CD4/CD3 lymphocyte ratio along with a low αSMA/vimentin ratio is correlated with poorer survival. (hal.science)
Working with colleagues from the Cancer Registry of Norway, Gauthier Bouche and Pan Pantziarka of the Anticancer Fund have investigated the effects of different drugs on pancreatic cancer patients. (anticancerfund.org)
The results, as reported in a new paper ' Use of non-cancer drugs and survival among patients with pancreatic adenocarcinoma: a nationwide registry-based study in Norway ' (Støer et al, Acta Oncologica), show that patients treated with statins and non-selective beta blockers had better survival than pancreatic cancer patients not treated with those drugs. (anticancerfund.org)
Resection remains the only cure for pancreatic cancer, which is available only to the minority of patients diagnosed at early stage. (jhoponline.com)
This case demonstrates that oxaliplatin 42.5 mg/m 2 (ie, 50% dosing) could be safely administered in patients with pancreatic cancer immediately before hemodialysis. (jhoponline.com)
1,2 Surgical resection remains the only cure for pancreatic cancer, which is only possible for patients with localized disease and without significant vascular involvement. (jhoponline.com)
5 According to a meta-analysis review of clinical trials examining the use of neoadjuvant FOLFIRINOX therapy for patients with pancreatic cancer, an estimated 68% of patients with borderline resectable disease will successfully undergo resection after 4 to 9 cycles of neoadjuvant FOLFIRINOX, with each cycle administered every 14 days. (jhoponline.com)
Patients and Methods Screening outcomes were collected from three European centers that conduct prospective screening in high-risk groups including families with clustering of PDAC (familial pancreatic cancer [FPC]) or families with a gene defect that predisposes to PDAC. (medscape.com)
Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease: A national cohort study. (cancercentrum.se)

Association between Contrast-Enhanced Computed Tomography Radiomic Features, Genomic Alterations and Prognosis in Advanced Lung Adenocarcinoma Patients. (cdc.gov)

However, the application of amino acid metabolism in the prognosis of colon adenocarcinoma (COAD) has not yet been explored. (frontiersin.org)
Effects of concurrent TP53 mutations on the efficacy and prognosis of targeted therapy for advanced EGFR mutant lung adenocarcinoma. (cdc.gov)

Hereditary factors play a role in the development of PDAC in 3% to 5% of all patients. (medscape.com)
Currently, surgical resection is the only potentially curative treatment for PDAC, but in approximately 80% of symptomatic patients, the tumor is already unresectable at the time of diagnosis. (medscape.com)

More than 9 in 10 stomach cancers (95%) are adenocarcinoma. (macmillan.org.uk)
It represents 1.64% of intervention could reduce the risk for amination using a long forward viewing all cancers in Egypt, according to the adenocarcinoma of the distal stomach instrument (Fuji, EG 250D video). (who.int)
CDC analyzed data carcinomas of the cervix (i.e., squamous cell cancers [SCC], for 2013-2017 from central cancer registries linked with the adenocarcinomas, and other carcinomas) and SCC of the vulva, Indian Health Service (IHS) patient registration database to vagina, penis, oropharynx, and anus (including rectal SCC) ( 1 ). (cdc.gov)

Reports on laparoscopic total mesorectum excision (TME) for cancer are often retrospective and contain heterogeneous patients who had several types of resection (i.e., anterior resection, low anterior resection, all or partially laparoscopic). (sages.org)
The patient was treated by tumor resection. (hindawi.com)
endoscopic polypectomy may allow curative resection of invasive adenocarcinoma on colorectal adenoma. (isciii.es)
Our goal is was to determine the factors associated with complete endoscopic resection of invasive adenocarcinoma. (isciii.es)
Finally, the resection was in one piece in 73.5% and incomplete in 8.6% of the adenocarcinomas. (isciii.es)
endoscopic polypectomy allows complete resection of 91.4% of invasive adenocarcinomas on colorrectal adenoma in our series. (isciii.es)
Background - In the present study, we aimed to describe, at the population level, patterns of adjuvant treatment use after curative-intent resection for pancreatic adenocarcinoma (PCC) and to identify independent predictors of adjuvant treatment use. (ices.on.ca)
Methods - In this observational cohort study, patients undergoing PCC resection in the province of Ontario (population 13 million) during 2005-2010 were identified using the provincial cancer registry and were linked to administrative databases that include all treatments received and outcomes experienced in the province. (ices.on.ca)
5 Neoadjuvant therapy is also recommended by the National Comprehensive Cancer Network (NCCN) for patients with high-risk clinical and laboratory features to promote successful resection. (jhoponline.com)
High resection rate improves overall survival in elderly patients with pancreatic head cancer - A cohort study. (cancercentrum.se)

Primary adenocarcinomas of the vulva are rare and especially the villoglandular mucinous adenocarcinoma of intestinal type is rare variant of vulvar adenocarcinoma. (hindawi.com)
In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
In the published articles [ 2 ], intestinal type mucinous adenocarcinoma was also taken as a synonymous with villoglandular mucinous adenocarcinoma. (hindawi.com)
Villoglandular mucinous adenocarcinoma arises in the surface epithelium of the vulva. (hindawi.com)
But still the mechanisms of development of villoglandular mucinous adenocarcinoma in vulva are controversial. (hindawi.com)
P =0.04) and more likely to have mucinous adenocarcinomas ( P= 0.003), and tended to survive longer ( P =0.11) than those with sporadic cases. (oncotarget.com)

In China, which has the largest number of smokers and lung cancer cases in the world, the acinar tissue architectural pattern is by far the most common histological subtype of adenocarcinoma, comprising about 40% of all adenocarcinomas, and its incidence has increased significantly in recent decades. (wikipedia.org)
Despite the declining incidence of cervical carcinoma, the proportion of adenocarcinomas arising from the uterine cervix has risen steadily ( 8 , 9 ). (iiarjournals.org)
To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
The researchers found that during 2,081,051 person-years of follow-up, 228 of the patients with nonerosive GERD developed esophageal adenocarcinomas (incidence rate, 11.0/100,000 person-years). (msdmanuals.com)
Among those with erosive esophagitis at endoscopy, there were 542 esophageal adenocarcinomas during 1,750,249 person-years (incidence rate, 31.0/100,000 person-years), with an increased overall standardized incidence ratio of 2.36, which became more pronounced with longer follow-up. (msdmanuals.com)

Patients and Methods: We reviewed 18 cytological samples obtained from 14 patients with GEA. (iiarjournals.org)
Methods: Data from patients diagnosed with periampullary cancer from 2010 to 2019 were retrieved from the. (lu.se)

However, a substantial proportion of gastric adenocarcinomas are advanced or metastatic disease at the time of diagnosis. (biomedcentral.com)
The multicenter, randomized, double-blind, placebo-controlled KEYNOTE-859 trial enrolled patients with histologically or cytologically confirmed locally advanced or metastatic adenocarcinoma of the stomach or GEJ who received no prior treatment, had a known PD-L1 status, were HER2 negative and had an ECOG performance status of 0 or 1. (ajmc.com)

Endocervical adenocarcinoma (EAC) accounts for 20-25% of all cervical carcinomas ( 7 ). (iiarjournals.org)
Bioinformatics analysis revealed that ABHD11-AS1 levels are up-regulated in lung adenocarcinomas (LUADs) tissues and associated with worse overall survival of LUAD patients but not in lung squamous cell carcinomas. (cdc.gov)

Current study aimed to develop and validate prognostic nomograms for patients with metastatic gastric adenocarcinoma treated with palliative gastrectomy. (biomedcentral.com)
The development dataset comprised 1186 patients from the Surveillance, Epidemiology, and End Results Program who were diagnosed with metastatic gastric adenocarcinoma in 2004-2011, while the validation dataset included 407 patients diagnosed in 2012-2015. (biomedcentral.com)
Our survival nomograms for patients with metastatic gastric adenocarcinoma undergoing palliative gastrectomy can assist surgeons in treatment decision-making and prognostication. (biomedcentral.com)
FRIDAY, Sept. 1, 2023 -- For patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma, zolbetuximab, a monoclonal antibody that. (medworm.com)
This guidance updates and replaces NICE technology appraisal guidance 669 on trifluridine-tipiracil for treating metastatic gastric cancer or gastro-oesophageal junction adenocarcinoma after 2 or more therapies. (nice.org.uk)

A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023. (medworm.com)

The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
la polipectomía endoscópica puede permitir la resección con intención curativa del adenocarcinoma invasivo sobre adenoma de colon. (isciii.es)
Se incluyeron 151 individuos con un adenocarcinoma invasivo sobre adenoma resecado endoscópicamente entre 1999 y 2009. (isciii.es)
la polipectomía endoscópica permite la resección completa del 91,4% de los adenocarcinomas invasivos sobre adenoma en nuestra serie. (isciii.es)

NSCLC mainly includes the histologic types of adenocarcinoma (ADC) and squamous cell carcinoma (SCC) [ 2 ]. (jcancer.org)
Adenocarcinoma ("adeno" = "gland", "carcinoma" = cancer of epithelium) is the most common type of lung cancer in the U.S., Japan, and most of Western Europe, although it is the second most common form in Eastern parts of Europe (after squamous cell carcinoma). (wikipedia.org)

The prognostic implication of histopathologic subtyping of pulmonary adenocarcinoma according to the classification of the World Health Organization. (wikipedia.org)
Here, we report a severe case of IA with high arthritis disease activity in advanced pulmonary adenocarcinoma, causing permanent withdrawal of pembrolizumab, but the patient remained in complete remission (CR) 20 mo after the development of IA. (wjgnet.com)

Furthermore, compared to the tumor, lymph node, metastasis (TNM) staging system, histone modifications can discriminate the survival difference more accurately, especially for patients with stage I or stage II tumors. (oncotarget.com)
Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. (biomedcentral.com)
Adenocarcinoma accounts for the majority of gastric cancer diagnoses, and patients with gastric adenocarcinoma often experience relatively short survival times. (biomedcentral.com)
A previous systematic review and meta-analysis of 14 studies comprising 3003 patients with incurable advanced gastric cancer revealed that palliative gastrectomy significantly improved overall survival [ 9 ]. (biomedcentral.com)
Moreover, a recent study based on the Surveillance, Epidemiology, and End Results Program (SEER) data demonstrated a survival benefit for palliative gastrectomy in gastric cancer patients with stage IV disease after balancing baseline characteristics using propensity score matching analysis [ 10 ]. (biomedcentral.com)
Generally, survival is better in all stages for patients with the acinar (or papillary) pattern than it is in patients with the solid pattern, but considerably worse than those with the bronchioloalveolar pattern. (wikipedia.org)
Survival is significantly better in patients whose tumors are well differentiated (i.e. the glands and/or tubules are more completely developed) than when poorly differentiated (i.e. with rudimentary glands). (wikipedia.org)
If we compare cancer patients treated with different drugs to those not treated with those drugs we can see if there is a difference in survival. (anticancerfund.org)
High levels of cleaved caspase-3 were found in 14.6 % of patients and this correlated with a significantly better overall survival (p = 0.03). (rcsi.com)
38.9 % of patients had high cytoplasmic LC3B expression, which correlated with poor overall survival (p = 0.041). (rcsi.com)
In addition, a distinct globular pattern of LC3B expression was identified in 40.3 % of patients and was also predictive of overall survival (p (rcsi.com)
When these markers were assessed in combination, it was found that patients who showed low/negative cleaved caspase-3 staining and high/positive staining for both patterns of LC3B had the worst overall survival (p (rcsi.com)
Clinical characteristics and their influences on the survival of leptomeningeal metastasis derived from lung adenocarcinoma harboring epithelial growth factor receptor mutation]. (cdc.gov)
Effect of Different Timing of Local Brain Radiotherapy on Survival of EGFR-Mutated NSCLC Patients with Limited Brain Metastases. (cdc.gov)

Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients. (tcd.ie)

High-mobility group protein box 1 (HMGB1) is overexpressed and reported to be a prognostic factor in patients with non-small-cell lung cancer (NSCLC). (jcancer.org)
This case is reported due to the rarity of cutaneous metastasis at multiple sites from a highly aggressive adenocarcinoma in a young patient, to emphasize the importance of cutaneous metastasis as a poor prognostic sign in patients with a history of cancer. (lww.com)
Prognostic Significance of Volumetric Parameters Based on FDG PET/CT in Patients with Lung Adenocarcinoma Undergoing Curative Surgery. (cdc.gov)
Prognostic value of genes related to cancer-associated fibroblasts in lung adenocarcinoma. (cdc.gov)

Irinotecan hydrochloride is under clinical development by CSPC Pharmaceutical Group and currently in Phase II for Metastatic Adenocarcinoma of The Pancreas. (pharmaceutical-technology.com)
Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
The entire patient chart, including EGD, pathology, manometry, radiographic and clinician reports, was reviewed for demographic and clinical data and to determine the etiology of dysphagia. (who.int)
Clinical and laboratory data over time for a heart-lung transplant patient in France who had cytolytic hepatitis caused by HCirV-1 develop. (cdc.gov)

Lifestyle modification is an effective first-line therapy for GERD, yet patients rarely receive adequate counseling to maximize needed behavioral change. (cdc.gov)

The aim of this study was to explore potential associations between genetic polymorphisms of HMGB1 and EGFR mutations in a cohort that included 280 patients with NSCLC, some of whom were smokers and others who never smoked. (jcancer.org)
We found that after adjusting for other covariates, NSCLC patients who smoked and who respectively had CG, CT, and TC heterozygotes of HMGB1 rs2249825, rs1045411, and rs1360485, were at lower risk of developing mutant EGFR , compared to those patients with wild-type homozygotes. (jcancer.org)
Moreover, significant inverse associations between the CG and CG + GG genotypes of HMGB1 rs2249825 and the EGFR hotspot mutation, an exon 19 in-frame deletion, were also observed among NSCLC patients. (jcancer.org)
Within patients harboring mutant EGFR , HMGB1 rs1360485 C (TC + CC) allele carriers were at higher risk of developing poorly differentiated cancer types (odds ratio=5.493, 95% confidence interval: 1.130~26.696, p =0.019), compared to patients with TT homozygotes. (jcancer.org)
Furthermore, we found that HMGB1 rs1360485 polymorphisms seemed to be related to susceptibility to developing poorly differentiated cancer linked to tobacco consumption in EGFR mutant patients. (jcancer.org)
In conclusion, our results suggested that HMGB1 variants are significantly inversely associated with EGFR mutations among NSCLC patients who smoked. (jcancer.org)
However, 25% to 30% of patients with EGFR -activating mutations show intrinsic resistance, and the responders invariably acquire resistance to gefitinib. (aacrjournals.org)
Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
Concordance of Abundance for Mutational EGFR and Co-Mutational TP53 with Efficacy of EGFR-TKI Treatment in Metastatic Patients with Non-Small-Cell Lung Cancer. (cdc.gov)
Computed Tomography-derived intratumoral and peritumoral radiomics in predicting EGFR mutation in lung adenocarcinoma. (cdc.gov)

The International Endocervical Adenocarcinoma Criteria and Classification (IECC) reliably segregated EACs into human papillomavirus (HPV)-related and HPV-unrelated tumors according to the presence or absence of HPV infection-related morphology (apical mitotic figures and basal apoptotic bodies), which is easily identifiable under scanning magnification ( 12 ). (iiarjournals.org)

Colon adenocarcinoma (COAD) is the most common type of colorectal cancer ( 1 ). (frontiersin.org)
Unveiling the metal mutation nexus: Exploring the genomic impacts of heavy metal exposure in lung adenocarcinoma and colorectal cancer. (cdc.gov)

The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)

Oesophageal adenocarcinoma tumour tissue from the Northern Ireland Biobank at Queens University Belfast was examined retrospectively. (rcsi.com)

These tumors are managed expectantly and surgical management is considered only when the patient becomes symptomatic [ 2 ]. (hindawi.com)

According to GlobalData, Phase II drugs for Metastatic Adenocarcinoma of The Pancreas have a 42% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
Eleven years ago, the patient underwent an open laparotomy for complicated symptomatic gall stone disease and was incidentally detected to have a space occupying lesion of the head of pancreas. (hindawi.com)

Although histopathologic examination is required to arrive at a definitive diagnosis, radiologists must be cognizant of these entities and must be able to provide reasonable differential diagnoses because these can greatly impact patient management decisions. (medscape.com)

Patients with locally advanced rectal carcinoma (uN+/uT4) occasionally underwent preoperative radiation or chemoradiation. (sages.org)

Surgery provides a curative opportunity for a number of patients and is considered the foundation of multimodal management of gastric cancer. (biomedcentral.com)

In this study we assessed microRNA (miRNA) regulation in two populations of malignant Embryonal Carcinoma (EC) stem cell, which differentiate (NTera2) or remain undifferentiated (2102Ep) during tumourigenesis, and compared this to miRNA regulation in ovarian serous carcinoma (OSC) patient samples. (tcd.ie)
Polymorphous low-grade adenocarcinoma (PLGA) is a malignant tumor which occurs predominantly in minor salivary glands and exhibits low tendency for aggressive behavior and metastatic spread. (bvsalud.org)
Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped malignant cells in the neoplastic tissue form acini and tubules. (wikipedia.org)
In 1-2% of endoscopic polypectomies, the adenocarcinoma is observed to be invading the submucosa indicating a malignant polyp (2). (isciii.es)
The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)

The index case is being presented for its rarity and probable poor outcome in young patients and to stress on the fact that the possibility of primary prostatic adenocarcinoma should be investigated in a male presenting with bone metastasis irrespective of the age. (jpalliativecare.com)
Fine-needle aspiration cytology of the nodule revealed it to be metastasis from gastric adenocarcinoma. (lww.com)
Cutaneous metastasis may be the first presentation of internal malignancies even with a short history of disease in young patients. (lww.com)

The goal of this study was to assess the feasibility, safety, and effectiveness with respect to perioperative and oncological outcomes in two prospective series of all laparoscopic total mesorectal excision for rectum adenocarcinoma, one with, the other without anal sphincter preservation. (sages.org)
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o. (medscimonit.com)

Between November 2000 and July 2008, 104 unselected patients had laparoscopic TME for rectal adenocarcinoma. (sages.org)

The specimen of the vulvar biopsy was diagnosed vulvar adenocarcinoma. (hindawi.com)
This photomicrograph revealed some of the histopathologic changes exhibited in a lung tissue specimen, which had been harvested from a patient with adenocarcinoma of the lung. (cdc.gov)

SD has been shown to develop more frequently in patients with chronic viral hepatitis without precursor lesions, whereas LD lesions have been found more frequently in patients with chronic bile duct disease. (medscape.com)

We report an uncommon association of colon cancer in a patient with VCFS and 22q11.2 microdeletion. (scitechnol.com)

The patient remains free of disease 5 years after surgery. (hindawi.com)
Surgery is generally not a priority recommendation in such circumstances, except for patients with potentially life-threatening complications such as gastrointestinal bleeding, perforation, or obstruction. (biomedcentral.com)
A panel of three genetic markers may help to identify patients with early-stage lung cancer who have a very strong likelihood of their disease returning after surgery, according to findings from a study by NCI researchers. (nih.gov)
The acceptance of colposcopic evaluation as an intermediate step to identify patients who truly require surgical therapy has resulted in a dramatic decrease in such unnecessary surgery. (medscape.com)

Colonoscopy was incomplete in 84% of the patients and 60.3% had synchronous adenomas. (isciii.es)
Lynch syndrome was confirmed in eight patients (4%), all of whom had synchronous/metachronous malignancies without noticeable familial histories. (oncotarget.com)

We included 151 patients with invasive adenocarcinoma on adenomas endoscopically resected between 1999 and 2009. (isciii.es)

A randomized phase II study evaluating oxaliplatin alone (OXA), infusional 5-fluorouracil alone (5-FU) and an oxaliplatin/infusional 5-FU combination (OXFU) in untreated advanced pancreatic adenocarcinoma has been conducted. (nih.gov)

Acinar adenocarcinomas are the most common form of prostate gland malignancy. (wikipedia.org)
Background/Aim: Gastric-type endocervical adenocarcinoma (GEA) is a rare but distinct histological type of gynecological malignancy. (iiarjournals.org)

OSC patient samples displayed decreased expression of miRNA biosynthesis genes, decreased expression of mature miRNAs and prominent clustering to chromosome 14 but not 19. (tcd.ie)

Lung adenocarcinoma (LAC) is the most common form of lung cancer that increases in non-smokers at younger age. (muni.cz)
Prostate cancer is common in older patients. (jpalliativecare.com)
Adenocarcinoma is the most common type of stomach cancer. (macmillan.org.uk)
Although gastric adenocarcinoma is common in middle- and old-aged population, it is rare in young people. (lww.com)
Gastric adenocarcinoma is one of the common causes of cancer death in the world. (lww.com)
Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. (oncotarget.com)
Venous thromboembolism (VTE) as the most common cancer -associated complication has become the second death -causing reason among cancer patients . (bvsalud.org)

Adenocarcinoma starts in the glandular cells of the stomach lining. (macmillan.org.uk)

We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential. (who.int)

Anatomy17

Organisms4

Diseases78

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Psychiatry and Psychology1

Phenomena and Processes19

Disciplines and Occupations2

Information Science5

Health Care15

Esophageal adenocarcinoma8

Ductal16

Chemotherapy17

Pancreatic cancer11

Lung adenocarcinoma patients1

Prognosis2

PDAC2

Cancers3

Resection10

Mucinous6

Incidence5

Methods2

Advanced or metastatic2

Carcinomas2

Metastatic gastric5

20231

Adenoma4

Squamous2

Pulmonary adenocarcinoma2

Survival14

Serous adenocarcinoma1

Prognostic4

Clinical4

GERD1

EGFR10

Classification1

Colorectal cancer2

Proportion1

Tumour1

Tumors1

Pancreas2

Diagnoses1

Locally advanced1

Curative1

Malignant5

Metastasis3

Outcomes2

Laparoscopic1

Specimen2

Precursor1

Colon1

Surgery4

Synchronous2

Invasive1

Phase II1

Malignancy2

Genes1

Common7

Glandular1

Endoscopic examination1