• Reports on laparoscopic total mesorectum excision (TME) for cancer are often retrospective and contain heterogeneous patients who had several types of resection (i.e., anterior resection, low anterior resection, all or partially laparoscopic). (sages.org)
  • One week later, the patient was submitted to subtotal tumor resection, and remained asymptomatic in the post-operative period. (thieme-connect.de)
  • in the imaging control 3.5 years after the surgical resection, local recurrence was identified, and the patient was submitted to a local radiation protocol. (thieme-connect.de)
  • He underwent resection of locally advanced squamous cell carcinoma of the tongue base and received adjuvant radiation therapy. (acpinternist.org)
  • A multimodal radiotherapy-containing approach is a well-tolerated component of treatment for patients with osteosarcomas undergoing programed resection, allowing low toxicity rates while maintaining high local control rates. (cun.es)
  • Patients underwent concurrent cisplatin-based chemotherapy and radiation therapy (RT) after maximal transurethral resection of bladder tumor (TURBT) plus neoadjuvant or adjuvant chemotherapy. (urotoday.com)
  • This is a 78-year-old man who was diagnosed with ACC in oral cavity 19 years ago and underwent resection. (hindawi.com)
  • These data led to approval by the US Food and Drug Administration (FDA) for adjuvant nivolumab in patients at high risk for recurrence after undergoing radical resection of UC [2]. (nursingcenter.com)
  • The patient underwent gross total resection with adjuvant chemotherapy and radiation. (surgicalneurologyint.com)
  • PURPOSE: Randomized phase III trial to determine the effectiveness of adjuvant chemotherapy in treating women who have undergone resection for local and/or regional relapsed breast cancer. (stanford.edu)
  • We hypothesized that adding stereotactic body radiation therapy (SBRT) to anti-PD-1 would be safe prior to definitive surgical resection and would enhance pathological response compared with historical cohorts of patients with locoregionally advanced HNSCC treated with checkpoint inhibitor alone. (bmj.com)
  • Eligible patients were treated with neoadjuvant SBRT at a total dose of either 40 Gy in 5 fractions or 24 Gy in 3 fractions, delivered in a 1-week timespan, with or without nivolumab, prior to definitive surgical resection. (bmj.com)
  • The patient was managed with colonic resection and made an uneventful recovery. (scielo.org.za)
  • A total of 245 patients who underwent their first surgical resection for sporadic CRC were enrolled and CIMP status of the CRCs was determined using the quantitative MethyLight assay. (biomedcentral.com)
  • Eight patients underwent SRS as a primary treatment and 15 as adjuvant therapy to the resection cavity. (stanford.edu)
  • Of the 6 patients who underwent surgical resection, five cases were confined to lung tissue (T1), one case had mediastinal invasion (T3), two cases had regional lymph node metastasis (N1), and none had distal metastasis. (bvsalud.org)
  • Tumor recurrence or incomplete resection may occur in some patients with NFPAs, and management strategies for these NFPAs remain unclear. (cns.org)
  • In this review, the authors critically evaluated the evidence to support the options of repeat microsurgical resection, stereotactic radiosurgery (SRS), stereotactic radiotherapy (SRT), and fractionated radiation therapy (XRT). (cns.org)
  • Repeat resection, SRS, SRT, and XRT play a role in the management of patients with recurrent or residual NFPAs. (cns.org)
  • SRS or some type of radiation therapy is typically performed for patients with residual tumor or tumor recurrence after resection. (cns.org)
  • Should patients with recurrent or residual nonfunctioning pituitary adenomas (NFPAs) undergo stereotactic radiosurgery (SRS), fractionated radiation therapy (eg, XRT, fractionated stereotactic radiotherapy [SRT], or intensity modulated radiotherapy[IMRT]), or repeat resection? (cns.org)
  • Radiosurgery or radiation therapy for NFPAs is recommended when residual/recurrent sellar or parasellar tumor exists and the risk of a repeat resection is high. (cns.org)
  • Patients with low-grade pineocytomas can be observed cautiously after complete surgical resection without adjuvant radiation because no clear evidence shows that radiotherapy is beneficial. (medscape.com)
  • It is estimated that more than half of cancer patients undergo radiotherapy during the course of their treatment. (unboundmedicine.com)
  • Although improvements in radiotherapy techniques and instruments could reduce these side effects, there are still important concerns for cancer patients. (unboundmedicine.com)
  • To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. (cun.es)
  • Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to December 2008. (cun.es)
  • earlier cohort exclusively underwent radical mastectomy plus adjuvant radiotherapy, while later cohort had radical mastectomy alone. (scirp.org)
  • During the 50 years, radical mastectomy alone compared with radical mastectomy plus adjuvant radiotherapy is associated with a significantly higher cure rate, and higher survivals regardless of whether the death was from breast cancer, second cancer, benign causes or any causes. (scirp.org)
  • The purpose of the present paper is to gain a new insight into such extraordinarily long-term follow-up information, in particular, on the effects of adjuvant radiotherapy, which would not have been obtained without ordinary follow-up. (scirp.org)
  • Methods The Neoadjuvant Immuno-Radiotherapy Trial was an investigator-initiated single institution phase Ib clinical trial that enrolled patients with previously untreated locally advanced HPV-positive and HPV-negative HNSCC between 2018 and 2019. (bmj.com)
  • Furthermore, 15%-30% of patients treated with BCS do not receive adjuvant radiotherapy [ 3 , 4 ]. (e-roj.org)
  • Treatment of Glioblastoma Multiforme with Radiotherapy and Concomitant and Adjuvant Temozolomide: Translation of Randomised Controlled Trial Evidence into Routine Clinical Practice. (medscape.com)
  • Current treatment protocols for patients older than 3 years who have malignant pineal region tumors include radiotherapy. (medscape.com)
  • Early clinical trials of patients treated with radiotherapy reported significant mortality. (medscape.com)
  • Since 1953, at least 35 cases of radiation-induced meningioma have been reported in children after radiotherapy for pineal region tumors. (medscape.com)
  • Standard radiotherapy protocols for children with malignant pineal cell tumors use 4000 cGy of whole brain radiation followed by 1500 cGy to the pineal region. (medscape.com)
  • For children with malignant germ cell tumors, standard treatment is focal radiotherapy followed by radiation to the ventricular field. (medscape.com)
  • As with radiotherapy, the response to chemotherapy for patients with pineal region tumors varies according to tumor histology. (medscape.com)
  • 2.Patient has received extended-field radiotherapy or limited field radiotherapy = 2 weeks prior to randomization, and has not recovered to grade 1 or better from related side effects of such therapy (with the exception of alopecia or other toxicities not considered a safety risk for the patient at investigator's discretion). (who.int)
  • Treatment is primarily surgical, but in patients with lymph node metastasis, postoperative radiotherapy is recommended as well. (medscape.com)
  • Patients then usually undergo radiation therapy after surgery as an adjuvant treatment to prevent recurrence. (wikipedia.org)
  • Adjuvant therapy is given to patients with cancer as a secondary form of treatment to minimize the risk of recurrence by targeting undetectable metastases. (wikipedia.org)
  • Recurrence developed in 49 patients (47.1 %) including distant or peritoneal metastases (32 patients) and loco-regional recurrence (11 patients). (sages.org)
  • One of these five patients had a regional-only recurrence and did not receive elective radiation to the neck. (cancernetwork.com)
  • however, one patient suffered from rapid recurrence and metastasis. (surgicalneurologyint.com)
  • The therapy is also used, as what is called adjuvant therapy, to prevent the recurrence of hormone-receptor positive breast cancers after patients have undergone surgery and radiation therapy, if necessary. (sharsheret.org)
  • In addition, the three-year recurrence-free survival (RFS) of 124 patients with stage II or stage III CRC was analyzed in order to assess the effectiveness of fluoropyrimidine-based adjuvant chemotherapy with respect to CIMP status. (biomedcentral.com)
  • METHODS: The objective was to analyze a group of 43 patients with diagnosis of synovial sarcoma of the extremities treated surgically and determine (1) global survival rate, (2) survival rate free of events, (3) local recurrence rate and (4) oncological risk factors. (bvsalud.org)
  • Several studies demonstrate that patients receiving less than 5000 cGy are at risk for recurrence, strongly suggesting that this is the optimal total dose of radiation. (medscape.com)
  • These patients' cases should be followed carefully with serial MRIs to assess tumor recurrence or progression. (medscape.com)
  • This study aims to validate the modeled recurrence-free survival against 'gold-standard' estimates from data collected by the National Program of Cancer Registries (NPCR) Patient-Centered Outcomes Research (PCOR) project. (cdc.gov)
  • RESULTS: When grouping patients with stages I-III, the 5-year metastatic recurrence-free modeled and NPCR-PCOR estimates are very similar being respectively, 90.2 % and 88.6 % for female breast cancer, 74.6 % and 75.3 % for colon cancer, and 68.8 % and 68.5 % for rectum cancer. (cdc.gov)
  • This includes patients with muscle-invasive or node-positive disease after receiving neoadjuvant chemotherapy, or those with extravesicular extension or node-positive disease who did not receive neoadjuvant chemotherapy and were ineligible for or refused adjuvant cisplatin-based chemotherapy. (nursingcenter.com)
  • Of the 27 patients, 22 patients received a combination of surgery, radiation therapy, and/or chemotherapy: 9 (41%) underwent surgery plus adjuvant radiation, 8 (36%) underwent surgery plus adjuvant chemoradiation, 4 (18%) were treated with chemoradiation, and 1 (5%) had neoadjuvant chemotherapy followed by surgery and adjuvant radiation. (cancernetwork.com)
  • The patient opted for breast conservation with postoperative radiation and adjuvant systemic treatment. (medscape.com)
  • In a randomized trial among 300 patients with cervical cancer undergoing postoperative radiation, disease-free survival was similar with image-guided IMRT versus 3D-CRT (77 versus 81 percent), but three-year cumulative incidence of late toxicity was reduced (28 versus 49 percent) [3]. (nursingcenter.com)
  • Patients may also undergo postoperative radiation therapy per standard of care or adjuvant therapy at the investigator's discretion. (mycancergenome.org)
  • Right now, the best hope for that is to improve the primary treatments so that women do not develop metastatic disease with better adjuvant and neoadjuvant therapies--and there is considerable positive movement on that front. (tnbcfoundation.org)
  • It's critical though to determine which patients benefit from these approaches and when and how to use these therapies. (tnbcfoundation.org)
  • However, repurposing the use of approved therapies in patients with potentially targetable genomic alterations continues to be an emerging area of interest. (jnccn.org)
  • 2 , 3 Additionally, repurposing the use of approved targeted therapies in patients with specific genomic alterations or those with various genomic or metabolic abnormalities continues to be an emerging area of interest. (jnccn.org)
  • Due to the high risk associated with her family history, the patient underwent diagnostic bilateral breast MRI. (medscape.com)
  • 2003) Histology and clinical outcomes in patients with bilateral testicular germ cell tumors: the Memorial Sloan Kettering Cancer Center experience 1950 to 2001. (medscape.com)
  • Patients who have undergone bilateral oophorectomy are not eligible. (who.int)
  • Experts from University of California, Los Angeles Health and Mayo Clinic discuss key data presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting in the gynecologic and gastrointestinal cancer spaces and how they may impact patient care. (cancernetwork.com)
  • It has been said that African patients present late with aggressive tumors and face a lack of therapeutic options, resulting in short survival duration. (karger.com)
  • No differences in pCR and survival outcomes were seen between ACEI/ARB users and non-users among breast cancer patients receiving neoadjuvant chemotherapy. (jcancer.org)
  • 70% of patients while offering long-term survival rates comparable to contemporary cystectomy series. (urotoday.com)
  • It took us forever to do the trials for these agents, in part because we had a kind of false start with the research, but it's hard to ignore the survival improvements we are seeing in some patient groups with PARP inhibitors especially when they are combined with other drugs or immunotherapy. (tnbcfoundation.org)
  • Assuming that in all patients follow-up was terminated at 50 or 25 years after diagnosis, likelihood ratio test and stratified Log-rank tests were performed to evaluate the differences in cure rate and overall survival between the two cohorts. (scirp.org)
  • Although several studies have shown partial or even complete remission, there is no convincing evidence that systemic therapy will improve the survival duration of patients with adrenal cancer. (cancer.gov)
  • Radical open surgical excision is the treatment of choice for patients with localized malignancies and remains the only method by which long-term disease-free survival may be achieved. (cancer.gov)
  • Patients diagnosed with this disease have a poor prognosis, with survival rates of 14 to 15 months after diagnosis. (jnccn.org)
  • In a placebo-controlled phase III trial of over 700 patients with urothelial carcinoma (UC) and high-risk disease after radical cystectomy, one year of adjuvant nivolumab improved disease-free survival (median 21 versus 11 months) [1]. (nursingcenter.com)
  • In a phase III trial of almost 500 patients with unresectable or metastatic treatment-refractory GIST, the tyrosine kinase inhibitor (TKI) avapritinib resulted in similar progression-free survival (PFS) compared with the antiangiogenesis agent, regorafenib [4]. (nursingcenter.com)
  • However, among 13 patients whose tumors harbored a platelet-derived growth factor receptor alpha (PDGFRA) D842V mutation, avapritinib improved progression-free survival (median not reached versus 4.5 months). (nursingcenter.com)
  • In a phase 2 study of 91 patients with HER2 mutation-positive NSCLC that had progressed on standard treatment, the agent was associated with a median progression-free survival of 8.2 months, overall survival of 17.8 months, and response rate of 55 percent [5]. (nursingcenter.com)
  • Investigators report a trend in overall survival improvement among patients with advanced/recurrent endometrial cancer treated with atezolizumab and chemotherapy. (cancernetwork.com)
  • Results from the phase 3 GCIG INTERLACE trial highlight progression-free survival and overall survival improvements with induction chemotherapy plus chemoradiotherapy for patients with locally advanced cervical cancer. (cancernetwork.com)
  • Survival fraction of tumor and tissue were evaluated using a linear quadratic model of radiation dosage modified for thermal treatments. (cornell.edu)
  • Adjuvant breast radiation therapy is associated with increased locoregional control and patient-specific survival [ 1 ]. (allenpress.com)
  • The new standard of care is to combine hormone therapy with medications called CDK4/6 inhibitors to prolong progression-free survival for patients with metastatic cancer. (sharsheret.org)
  • It is unclear whether cytoreductive surgery prolongs the median survival in patients with malignant pleural mesothelioma. (standardofcare.com)
  • A previous study reported that CIMP positivity appears to result in improved survival among patients receiving 5-fluorouracil-based adjuvant chemotherapy for stage III CRC [ 22 ]. (biomedcentral.com)
  • Breast conserving surgery (BCS) and whole breast radiation (WBR) for women with early-stage breast cancer has been shown to be an equivalent alternative to mastectomy for local control and survival. (e-roj.org)
  • Oxaliplatin/5FU/LV in adjuvant colon cancer: updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years [abstract]. (medscape.org)
  • Radiation-induced deficits are an important consideration because many children with pineal region tumors enjoy prolonged survival. (medscape.com)
  • Germinomas are among the most radiosensitive tumors, with patient response rates and long-term tumor-free survival rates greater than 90% in most published series. (medscape.com)
  • Nongerminomatous malignant germ cell tumors are significantly less responsive to radiation, with a 5-year survival rate of 30-40% using this treatment alone. (medscape.com)
  • As modern improvements in surgical and adjuvant therapy are reflected in long-term survival, the rates of spinal metastasis will likely drop significantly, making the need for spinal irradiation obsolete. (medscape.com)
  • Long-term survival is poor except for patients with local disease. (msdmanuals.com)
  • We applied the modeling method to relative survival for patients diagnosed with female breast and colorectal cancer in 2000-2015 in the SEER-18 areas. (cdc.gov)
  • Among California breast cancer patients diagnosed from 1988–2013, nipple-sparing mastectomy was not associated with worse survival than non-nipple-sparing mastectomy. (cdc.gov)
  • We took advantage of the large population-based California Cancer Registry (CCR) to compare survival of stage 0–III female breast cancer patients treated with NSM versus non-NSM from 1988 to 2013. (cdc.gov)
  • Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
  • We investigated whether the use of ACEI/ARBs affects the clinical outcomes of primary breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy. (jcancer.org)
  • Report long-term outcomes of patients with muscle-invasive BCa treated by CMT. (urotoday.com)
  • To report the treatment outcomes of patients with sinonasal neuroendocrine tumors who were treated with a combination of surgery, radiation therapy, and/or chemotherapy at the Mayo Clinic in Arizona. (cancernetwork.com)
  • Researchers have investigated combining immunotherapy with SRS to enhance treatment outcomes in patients with brain metastasis. (stanford.edu)
  • The purpose of this study was to evaluate the safety and effectiveness of SRS for sarcoma BM.The authors retrospectively reviewed the clinical and radiological outcomes of patients with BM secondary to histopathologically confirmed sarcoma treated with SRS, either as primary treatment or as adjuvant therapy after surgery, at their institution between January 2005 and September 2022. (stanford.edu)
  • They also compared the outcomes of patients with hemorrhagic lesions and of those without.Twenty-three patients (9 females) with 150 BMs secondary to sarcoma were treated with CyberKnife SRS. (stanford.edu)
  • Our colleagues at the agency do a spectacular job determining the analytic accuracy, reproducibility, and reliability of the devices under evaluation, but they are not charged with the heavier burden of determining whether use of the diagnostic device actually improves patient outcomes. (ascopost.com)
  • A conceptual model of patients outcomes. (medscape.org)
  • Of particular interest are adjuvant therapy, treatment of metastatic disease, methods for treatment of locally advanced breast cancer and inflammatory breast cancer. (stanford.edu)
  • as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
  • 92% to 100% of patients with Paget's disease of the breast have an underlying breast cancer. (wikipedia.org)
  • Whether adjuvant therapy is needed depends upon the type of cancer and its staging. (wikipedia.org)
  • Another, related category of post are early alternative cancer cure testimonials, in which a recently diagnosed cancer patient is featured in the newspapers, usually in a credulous story that frames her (and it's usually a breast cancer patient) as "bravely" going against the establishment. (scienceblogs.com)
  • Anything that might influence new cancer patients to try quackery instead of effective medicine enrages me. (scienceblogs.com)
  • I heard about just such a story the other day, as I was perusing my e-mail after getting out of the operating room after a long day operating on breast cancer patients. (scienceblogs.com)
  • Two years prior, the patient was diagnosed with and treated for breast cancer . (medscape.com)
  • The patient subsequently underwent a 3-needle localized right lumpectomy (2-needle localization bracketing the area of cancer in the additional 8-o'clock position, with additional needle localization of the 4-o'clock mass) with sentinel lymph node biopsy and possible axillary node dissection. (medscape.com)
  • The patient was upstaged to a T2/N1mic/M0 stage IIB cancer, with an oncotype score of 26. (medscape.com)
  • 2005) Risk-adapted management for patients with clinical stage I seminoma: the second Spanish Germ Cell Cancer Cooperative Group Study. (medscape.com)
  • We included 1449 patients with diagnosis of invasive primary breast cancer diagnosed at the MD Anderson Cancer Center between 1995 and 2007 who underwent neoadjuvant chemotherapy. (jcancer.org)
  • To evaluate the effect of follow-up length on the outcome of breast cancer patients, we compared the 50- and 25-year follow-up results in terms of cure rate, overall mortality and mortalities from breast cancer, second cancer, and benign diseases. (scirp.org)
  • 763 patients treated for breast cancer between February 1953 and September 1976, were followed up until December 2014. (scirp.org)
  • The advantage of his model is that its parameters provide the information for clinicians and patients eagerly seek, such as the patient's chance of being cured, and if not cured, the time to death from the cancer. (scirp.org)
  • This is particularly true for breast cancer patients who have much longer times to death than those with other malignancies. (scirp.org)
  • Since the registration of breast cancer started at the Kyoto University Hospital in 1953, the first author of the present paper (Y.Y.) assumed the responsibility to follow all patients who were surgically treated. (scirp.org)
  • Because metformin has been reported to reduce prostate cancer-related death in patients with prostate cancer and type 2 diabetes , researchers at the University of Maryland in Baltimore sought to explore the effects of metformin with abiraterone or enzalutamide in preclinical models. (renalandurologynews.com)
  • The authors noted that further studies are warranted to evaluate the clinically efficacy of metformin in combination with either of these agents in patients with prostate cancer. (renalandurologynews.com)
  • We report a 61 years old male patient with the diagnosis of gastric cancer. (nepjol.info)
  • For adjuvant radiation for cervical cancer, newer techniques such as intensity- modulated radiation therapy (IMRT) are being evaluated as less toxic options compared with three-dimensional conformal radiation therapy (3D-CRT). (nursingcenter.com)
  • When adjuvant radiation is indicated for cervical cancer, we suggest image-guided IMRT, but 3D-CRT is an acceptable alternative. (nursingcenter.com)
  • Findings from the phase 2 SKYSCRAPER-04 trial support dual targeting of TIGIT and PD-L1 in patients with PD-L1-positive cervical cancer, says Ritu Salani, MD. (cancernetwork.com)
  • The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • It is not yet known whether chemotherapy is effective in treating women who have undergone surgery and radiation therapy for relapsed breast cancer. (stanford.edu)
  • Conclusion These data demonstrate that radiation delivered only to the gross tumor volume combined with immunotherapy was safe, resulted in a high rate of mPR and should be further evaluated as a locally focused neoadjuvant therapy for patients with head and neck cancer. (bmj.com)
  • This phase II trial studies how well biopsy of breast after chemotherapy works in predicting pathologic response in patients with stage II-IIIA breast cancer undergoing breast conserving surgery. (mycancergenome.org)
  • Recent approvals of immunotherapy agents for adjuvant and neoadjuvant therapy may support wider use among patients with non-small cell lung cancer treated with pneumonectomy. (medpagetoday.com)
  • Atrioventricular (AVN) and sinoatrial (SAN) nodes were retrospectively delineated according to published guidelines on the simulation computed tomography scans of 12 breast cancer patients having undergone conserving surgery and adjuvant locoregional volumetric modulated arc therapy. (allenpress.com)
  • Intensity-modulated proton therapy treatment was replanned on the simulation computed tomography scans for all breast cancer patients. (allenpress.com)
  • CDK4/6 inhibitors interrupt the growth of breast cancer cells and give patients more time before they must begin to receive chemotherapy. (sharsheret.org)
  • Raimonda Goldman, DO, cares for patients at Holy Name Medical Center's Patricia Lynch Cancer Center in Teaneck. (sharsheret.org)
  • UC San Diego Health is the first hospital system in San Diego to offer a new, highly targeted and precisely placed radiation therapy that delays tumor regrowth while protecting healthy tissue in patients with brain cancer. (medicalxpress.com)
  • As the only academic medical center in the region, UC San Diego Health is committed to offering patients with brain cancer the most innovative and effective treatments available," said Marc Schwartz, MD, neurosurgeon at UC San Diego Health. (medicalxpress.com)
  • The number of radiation sessions patients with brain cancer undergo can be stressful and time-consuming. (medicalxpress.com)
  • This new radiation therapy will allow us to provide select patients with recurrent brain tumors an alternative option," said Parag Sanghvi, MD, radiation oncologist at Moores Cancer Center at UC San Diego Health. (medicalxpress.com)
  • Multiple prospective randomized clinical trials, with decades of follow-up, have demonstrated that more than one-half of women with newly diagnosed early-stage breast cancer, when carefully evaluated by standard mammographic and pathologic techniques, can be safely treated with breast-conserving therapy with limited surgery and adjuvant radiation-arguably one of the great advances in breast cancer treatment of the 20th century. (ascopost.com)
  • Recently, accelerated partial breast radiation (APBR) was proposed as an alternative to WBR for patients with early stage breast cancer as it reduces treatment time. (e-roj.org)
  • In this study, a granulocyte PIG-A-mutant assay was evaluated in patients undergoing radiation therapy (RT) for breast cancer. (hal.science)
  • Actual breast cancer and breast reconstruction patient with Natrelle INSPIRA® Breast Implants. (natrelle.com)
  • This cancer occurs more commonly in patients with textured breast implants than smooth implants, although rates are not well defined. (natrelle.com)
  • Hewitt M, Greenfield S, Stovall E. From cancer patient to cancer survivor: lost in transition. (medscape.org)
  • Health-related quality of life of cancer and noncancer patients in Medicare managed care. (medscape.org)
  • Comparison of changes in physical functioning of elderly patients with new diagnoses of cancer. (medscape.org)
  • Given BA, Given C, Azzouz F, Stommel M. Physical functioning of elderly cancer patients prior to diagnosis and following initial treatment. (medscape.org)
  • Predictors of depressive symptomatology of geriatric patients with colorectal cancer: a longitudinal view. (medscape.org)
  • Patients with personal or family history of diffuse gastric cancer and/or lobular breast cancer in multiple family members, especially if they were diagnosed before age 50, should be referred for genetic counseling and testing. (msdmanuals.com)
  • 2.Patient has a histologically and/or cytologically confirmed diagnosis of estrogen-receptor positive and/or progesterone receptor positive breast cancer based on the most recently analyzed tissue sample and all tested by local laboratory. (who.int)
  • 6.Patients must have not received any prior hormonal therapy and chemotherapy for advanced breast cancer, except LHRH agonist. (who.int)
  • Patients who received = 14 days of tamoxifen or a NSAI (letrozole or anastrozole) with or without LHRH agonist for advanced breast cancer prior to randomization are eligible. (who.int)
  • 1.Patient has received prior systemic anti-cancer therapy (including hormonal therapy and chemotherapy, or any CDK4/6 inhibitor for advanced breast cancer. (who.int)
  • Patients who received (neo) adjuvant therapy for breast cancer are eligible. (who.int)
  • Patients who are receiving = 14 days of tamoxifen or NSAI or LHRH agonists = 28 days for advanced breast cancer prior to randomization are eligible. (who.int)
  • 3.Patient has a concurrent malignancy or malignancy within 3 years of randomization, with the exception of adequately treated, basal or squamous cell skin carcinoma, non-melanomatous skin cancer or curatively resected cervical cancer. (who.int)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
  • These results may inform the decisions of patients and doctors deliberating between these surgical approaches for breast cancer treatment. (cdc.gov)
  • Patients with endometrioid cancer and grade 1 or 2 histology localized to the uterus may undergo hysterectomy only and require no extensive dissection of lymph nodes. (medscape.com)
  • Both patients had tumors involving deeper than the inner third of the cervical wall. (nih.gov)
  • One hundred two patients (29%) underwent RC-60 for less than CR and 42 for recurrent invasive tumors. (urotoday.com)
  • Patients who have low-grade tumors without evidence of invasion into local tissues or spread to lymph nodes have an improved prognosis. (cancer.gov)
  • Unresectable or widely disseminated tumors may be palliated by adrenolytic therapy with mitotane, antihormonal drugs (i.e., ketoconazole and metyrapone), systemic chemotherapy, and/or radiation therapy. (cancer.gov)
  • In a phase II trial of the hypoxia-inducible factor-2alpha inhibitor belzutifan in 61 patients with VHL disease, objective response rates were 49 percent in systemic therapy-naive renal cell carcinoma (RCC), 30 percent in central nervous system (CNS) hemangioblastomas, and 91 percent in pancreatic neuroendocrine tumors (pNET) [6,7]. (nursingcenter.com)
  • It is known that the rare occurrence of malignant peripheral nerve sheath tumors (MPNSTs) in the background of NF1 is associated with a lifetime risk of developing MPNST in up to 13% of NF1 patients. (surgicalneurologyint.com)
  • Zhang, Michelle dc.description.abstract: Radiation therapy offers the ability to kill and shrink tumors non-invasively and serves as adjuvant therapy post-surgery and as primary therapy for patients unable to undergo surgery. (cornell.edu)
  • Tumors exposed to elevated temperatures of 40-45C during hyperthermia exhibit increased sensitivity to radiation therapy and are more likely undergo ablation. (cornell.edu)
  • The novel, FDA-cleared approach, called GammaTile, utilizes small radiation seeds, or brachytherapy, which are implanted at the tumor site during surgery and naturally absorbed into the body to treat malignant and recurrent brain tumors , including gliomas, glioblastomas and meningiomas. (medicalxpress.com)
  • In a clinical trial evaluating the treatment, the approach resulted in nearly twice as many tumor-free months compared to prior treatment for patients with recurring brain tumors located in the same area. (medicalxpress.com)
  • The previous standard of care for patients with operable brain tumors is surgical removal of the tumor followed by adjuvant therapy , including radiation and chemotherapy. (medicalxpress.com)
  • While the most common mutation was in TP53 , the OTSCC genetic landscape differed from previously described cohorts of patients with head and neck tumors: OTSCCs demonstrated frequent mutations in DST and RNF213 , while alterations in CDKN2A and NOTCH1 were significantly less frequent. (biomedcentral.com)
  • Methods: We identified 27 tumors from either the buccal mucosa patients or RMT patients who underwent surgery followed by radiation. (mssm.edu)
  • Chemotherapy has evolved as an attractive means of minimizing the amount of radiation needed to effectively treat children with pineal region tumors. (medscape.com)
  • Patients with extracranial nongerminomatous germ cell tumors respond well to treatment with a wide array of chemotherapeutic agents. (medscape.com)
  • Patients with intracranial nongerminomatous germ cell tumors have demonstrated response rates as high as 78% with some regimens. (medscape.com)
  • Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
  • Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)
  • In most cases, adjuvant treatment is part of the treatment schema. (wikipedia.org)
  • Postoperatively, adjuvant treatment was administered to patients with UICC stage II/III disease. (sages.org)
  • Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. (medscape.com)
  • Evidence on treatment from prospective randomized trials that address the specific characteristics of African patients is lacking. (karger.com)
  • Six patients (8%) developed grade ⩾3 treatment-related chronic toxicity events. (cun.es)
  • No patient required cystectomy for treatment-related toxicity. (urotoday.com)
  • Actinic keratosis is the premalignant precursor for cSCC, and early treatment will save the patient morbidity. (medscape.com)
  • Serial MRI scans are performed during the six weeks of prescribed treatment and some patients go on to receive six additional months of chemotherapy, following a discussion with their oncologist. (fusfoundation.org)
  • Given the rare incidence of RET alterations in GBM, findings from this report can help guide and support optimal treatment strategies for patients with RET -altered GBM. (jnccn.org)
  • 4 The selective RET inhibitor selpercatinib is poised to alter the treatment landscape for patients with RET -altered malignancies. (jnccn.org)
  • For patients with advanced gastrointestinal stromal tumor (GIST), novel agents are being evaluated in the treatment-refractory setting. (nursingcenter.com)
  • For patients with von Hippel-Lindau (VHL)-associated cancers, systemic treatment options are limited. (nursingcenter.com)
  • Patients were then planned for treatment with adjuvant nivolumab for 3 months. (bmj.com)
  • Results Twenty-one patients underwent neoadjuvant treatment, which was well tolerated and did not delay surgery, thus meeting the primary endpoint. (bmj.com)
  • This project models the treatment of subcutaneous squamous carcinoma using AuNP controlled hyperthermia and X-ray radiation therapy. (cornell.edu)
  • By optimizing the heating time and radiation dosage combination, we can reduce the total radiation exposure and the length of treatment, allowing for overall faster and less harmful treatments for patients. (cornell.edu)
  • This new treatment option may extend the lifespan for certain patients and improve their quality of life. (medicalxpress.com)
  • Does this increased treatment do these patients any good? (ascopost.com)
  • Patients were assessed for treatment related toxicities, and cosmesis, before APBR, during, and after completion of the treatment. (e-roj.org)
  • This prolonged duration presents obstacles particularly for elderly patients and those who reside long distance from treatment facilities. (e-roj.org)
  • Patients harboring mutations in actionable pathways were more likely to succumb from recurrent disease compared with those who did not, suggesting that the former should be considered for treatment with targeted compounds in future trials. (biomedcentral.com)
  • Radiosurgery and radiation therapy are recommended for treatment of residual or recurrent NFPAs to lower the risk of subsequent tumor progression. (cns.org)
  • Radiosurgery using single-session doses of 12 or more Gy or radiation therapy with fractionated doses of 45 to 54 Gy is recommended for greater local tumor control rate of 90% or higher at 5 years after treatment. (cns.org)
  • If the prior neo (adjuvant) therapy included aromatase inhibitors, the disease free interval must be greater than 12 months from the completion of aromatase inhibitor treatment until randomization. (who.int)
  • The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
  • Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
  • 5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
  • Before the mucositis lesions appeared, the patient had been given a treatment protocol that included methotrexate (50mg) at 8-day intervals. (bvsalud.org)
  • We obtained CCR information regarding patient and tumor characteristics, initial treatment course and patient vital status through December 31, 2013. (cdc.gov)
  • All patients underwent radical hysterectomy with pelvic lymphadenectomy. (nih.gov)
  • CONCLUSIONS: Approximately one in five U.S. women overall and half of U.S. women aged70years reported undergoing a hysterectomy. (cdc.gov)
  • She subsequently underwent adjuvant chemotherapy with docetaxel anhydrous, cyclophosphamide, and pegfilgrastim and postchemotherapy reexcision of her margins, with all new margins reported as negative. (medscape.com)
  • Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • He underwent distal subtotal gastrectomy with D2 lymphadenectomy. (nepjol.info)
  • A 64-year-old man with history of elevated PSA (8.5 ng/mL) and previous negative prostate biopsies underwent multiparametric prostate magnetic resonance imaging (MRI). (renalandurologynews.com)
  • To improve identification and selection of patients with breast and possible axillary pCR for future trial planning, routine biomarkers (estrogen receptor [ER], progesterone receptor [PR], HER2 neu, and Ki67) will be collected to allow comparison to image/clinical complete response (CR), and tumor bed biopsies. (mycancergenome.org)
  • Oncotype DX 21 ® generates a score of 0-100 based on 21 specific genes in breast tissue samples from patients' biopsies or surgery samples. (sharsheret.org)
  • Despite its beneficial therapeutic effects on tumor cells, exposure to high doses of ionizing radiation (IR) is associated with several side effects. (unboundmedicine.com)
  • The clinic pathological correlation of G9a and S SPRY 1 Immuno-histochemical expression was assessed in tumour specimens of paraffin blocks retrieved from 50 colorectal carcinoma patients. (omicsonline.org)
  • Because MRI is more sensitive than mammography and detects deposits of previously unrecognized cancers in up to 15% of patients who were considered good candidates for breast-conserving therapy. (ascopost.com)
  • Based on her family history of malignancy, the patient underwent further genetic testing. (medscape.com)
  • [ 3 ] An endometrial sample can be obtained with office biopsy, hysteroscopy , or D&C. The initial histologic test can differentiate between benign and malignant causes and in case of malignancy may determine the surgery the patient has to undergo. (medscape.com)
  • In the cases with lymph node metastasis, adjuvant radiation therapy was also given. (nih.gov)
  • SECONDARY OBJECTIVES: I. To collect axillary pathology results, surgical staging methods (sentinel lymph node biopsy and/or axillary lymph node dissection ), and management ( surgery and/or radiation) in order to determine axillary nodal response to neoadjuvant chemotherapy and its relationship to breast pCR. (mycancergenome.org)
  • We evaluated the feasibility and toxicity of APBR delivered using intensity-modulated radiation therapy (IMRT) in elderly patients with stage I BC, using a novel fractionation schedule. (e-roj.org)
  • The acceptable toxicity profile and cosmetic results of this study support the use of IMRT planned APBR with daily schedule in elderly patients with early stage BC. (e-roj.org)
  • The exposition of cardiac conduction system during breast radiation therapy has never been studied, despite the increasing use of intensity-modulated radiation therapy, which exposes larger volume to low-dose bath. (allenpress.com)
  • Such techniques include rotational intensity-modulated radiation therapy (IMRT) or proton therapy. (allenpress.com)
  • Median follow-up for surviving patients was 7.7 yr. (urotoday.com)
  • The median dose of radiation was 60 Gy (range: 42-66 Gy). (cancernetwork.com)
  • Our patients included 30 men and 20 women, with a median age of years 57 (range, 29 80 years). (omicsonline.org)
  • Results: The median time from surgery to radiation was 50 days (range, 32-133 days). (mssm.edu)
  • Following locoregional failure, 10 of the 12 patients have died, with a median time from local failure to death of 3.6 months (range, 1-17.6 months). (mssm.edu)
  • 1 Surgery, if feasible, followed by radiation therapy in combination with temozolomide is the standard of care for most patients with newly diagnosed GBM. (jnccn.org)
  • Inflammatory polyps may develop in patients taking nonsteroidal anti-inflammatory drug (NSAIDs), and fundic foveolar polyps are common among patients taking proton pump inhibitors. (msdmanuals.com)
  • Is Systemic Therapy Underused in NSCLC Patients Undergoing Pneumonectomy? (medpagetoday.com)
  • Based on these data, we consider avapritinib to be an acceptable option for patients with PDGFRA D842V mutation-positive GIST who have experienced progression on both imatinib and sunitinib. (nursingcenter.com)
  • Inclusion criteria included studies that involved more than 20 patients with a physician confirmed diagnosis of PD and a follow-up of greater than or equal to at least 12 months. (neurologyindia.com)
  • Patients with pleural effusions frequently require draining for symptom relief and diagnosis. (standardofcare.com)
  • Cardiotoxicity studies evaluating conduction node exposure might define dose constraints and criteria for additional cardiac-sparing techniques, such as respiratory techniques or proton therapy, which could benefit patients with underlying rhythmic or conduction disorders. (allenpress.com)
  • Each therapeutic seed, approximately the size of a postage stamp, contains radiation sources embedded in a collagen tile that together deliver a precise, targeted dose of radiation. (medicalxpress.com)
  • Nevertheless, rare observations of abscopal or out-of-field effects have sparked interest in the potential to elicit antitumor immunity via the administration of high-dose radiation. (stanford.edu)
  • Four patients had both local and distant metastases. (sages.org)
  • Initial findings have been encouraging in the management of various intracranial metastases, while further studies are required to determine the optimal order of administration, radiation doses, and fractionation regimens that have the potential for the best tumor response. (stanford.edu)
  • All patients had exophytic friable cervical masses. (nih.gov)
  • Given the central role that ultraviolet radiation (UVR) plays in the pathogenesis of cSCC, methods aimed at decreasing UVR exposure form the cornerstone of cSCC prevention. (medscape.com)
  • Peritoneal mesothelioma accounts for 10-15% of cases.Most patients with malignant pleural mesothelioma present late in the course of their disease, with an asymptomatic early process. (standardofcare.com)
  • More than 10% of patients with malignant mesothelioma have germline variants. (standardofcare.com)
  • A novel UCS cell line (PF338) was established from the malignant pleural effusion of a 59-year-old patient at time of disease progression. (por-journal.com)
  • The clinical picture of BC differs from that of Western countries due to the high proportion of young patients (on account of the African population with a high proportion of young people) and late presentation. (karger.com)
  • Furthermore, good adherence is associated with a better clinical outcome, and statin withdrawal is associated with a poor functional outcome in patients with ischemic stroke. (neurologyindia.com)
  • Clinical to pathological downstaging occurred in 90% of the patients treated. (bmj.com)
  • Based on multiple randomized clinical trials, we now prescribe extended hormone therapy for high-risk patients beyond five years after surgery. (sharsheret.org)
  • The relatively lax requirements for introduction of a new device into practice, compared with a new therapeutic drug, have contrasting implications: (1) faster speed and lower cost of implementation and (2) less confidence that they have clinical utility for patient care. (ascopost.com)
  • No one would argue that we need prospective randomized clinical trials to determine whether chest x rays or body scanning helps patient care. (ascopost.com)
  • During an outbreak of influenza, he found H. influenzae in patients' sputum and proposed a causal association between this bacterium and the clinical syndrome known as influenza. (cdc.gov)
  • Eosinophilic esophagitis (EoE) is uncommon but also underdiagnosed: Patients may not seek care for their symptoms, and physicians may not be aware of the condition. (acpinternist.org)
  • The findings from those studies on motor symptoms, medication requirements, quality of life, and independence in activities of daily living in PD patients are summarized and presented in tabulated form in this paper at the end. (neurologyindia.com)
  • In approximately 60% of patients, symptoms related to excessive hormone secretion are the main reason for seeking medical attention. (cancer.gov)
  • Both patients presented with local pain and myelopathic symptoms. (surgicalneurologyint.com)
  • Individual patient risk for developing these symptoms has not been well established. (natrelle.com)
  • Some patients report complete resolution of symptoms when the implants are removed without replacement. (natrelle.com)
  • Markedly symptomatic non visceral disease if the treating physician opt to give chemotherapy for rapid palliation of patients symptoms. (who.int)