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  • failure
  • Pneumonia caused by Pneumocystis jirovecii is an uncommon infection in kidney transplant patients that can have an acute and rapid progression to respiratory failure and death. (readbyqxmd.com)
  • However, it may occur late, associated with the suspension of prophylaxis with trimethoprim-sulfamethoxazole.We present two cases of renal transplant patients who had severe hypoxemic respiratory failure due to P. (readbyqxmd.com)
  • It is usually offered to patients who have insulin-dependent diabetes mellitus and those with diabetic nephropathy and renal failure that has already been established. (readbyqxmd.com)
  • One patient, heterozygous for a PKP2 nonsense mutation, developed severe heart failure and underwent cardiac transplantation. (nih.gov)
  • We measured CA expression in hypertrophied human hearts to begin to examine the role of carbonic anhydrase in progression of human heart failure. (biomedcentral.com)
  • Identification of basic mechanisms that promote the downward cascade of heart failure holds the promise to develop targeted new therapeutic strategies. (biomedcentral.com)
  • Altered ion homeostasis contributes to hypertrophic heart growth, which impairs the heart's ability to pump effectively and commonly progresses to heart failure. (biomedcentral.com)
  • Background -An increase in oxidative stress is suggested to be intimately involved in the pathogenesis of heart failure. (ahajournals.org)
  • Conclusions -Increased oxidative stress in human end-stage heart failure may result in a specific upregulation of catalase gene expression as a compensatory mechanism, whereas SOD and GPX gene expression remain unaffected. (ahajournals.org)
  • Increasing evidence suggests that oxidative stress mediated by the generation of oxygen free radicals plays a critical role in the pathogenesis of heart failure. (ahajournals.org)
  • During the last decade, considerable research effort has been directed at the identification of changes in oxidative stress and in antioxidative enzymes as one of the mechanisms underlying the development of heart failure. (ahajournals.org)
  • It has been reported that heart hypertrophy in rats and guinea pigs is associated with a decrease in oxidative stress and an increase in antioxidant reserve, 5 6 7 8 whereas heart failure under both acute and chronic conditions is associated with increased oxidative stress and a reduced antioxidant reserve. (ahajournals.org)
  • 6 9 10 11 In humans with chronic heart failure, products of free radical reactions, ie, plasma lipid peroxides, are elevated, whereas plasma thiols, as an index of the oxidative status of the extracellular environment, are decreased. (ahajournals.org)
  • 2 Expired breath pentane levels, as an index of lipid peroxidation, were found to be elevated in patients with heart failure as well. (ahajournals.org)
  • 12 Furthermore, it has been reported that plasma antioxidative enzyme activities were decreased in patients with ischemic heart disease and with heart failure. (ahajournals.org)
  • 16 18 However, gene expression of antioxidants in the human heart with end-stage heart failure has not been investigated. (ahajournals.org)
  • In view of increasing evidence for the involvement of oxidative stress in heart failure, it is of considerable interest to examine whether changes in antioxidative enzymes at the transcriptional or translational level may exist under chronic conditions in human heart failure. (ahajournals.org)
  • OBJECTIVES To document the degree of cognitive impairment in stable heart failure, and to determine its relation to the presence of Cheyne-Stokes respiration during sleep. (bmj.com)
  • SUBJECTS 104 heart failure patients and 21 healthy normal volunteers. (bmj.com)
  • METHODS Overnight oximetry was used (previously validated as a screening tool for Cheyne-Stokes respiration in heart failure). (bmj.com)
  • RESULTS Heart failure patients performed worse than the healthy volunteers in tests that measured vigilance. (bmj.com)
  • Cognitive impairment within the heart failure group was unrelated to either the presence of Cheyne-Stokes respiration, the degree of left ventricular dysfunction, or indices of nocturnal oxygenation. (bmj.com)
  • CONCLUSIONS Vigilance was impaired in heart failure but this did not appear to be related to the presence of Cheyne-Stokes respiration during sleep. (bmj.com)
  • The issue of fitness to drive in heart failure requires further attention. (bmj.com)
  • Clinical experience tells us that cognitive function is impaired in heart failure. (bmj.com)
  • Bornstein and colleagues documented significant levels of cognitive impairment in 50% of patients with end stage heart failure undergoing assessment for cardiac transplantation. (bmj.com)
  • The pathophysiology of cognitive impairment in heart failure is unclear. (bmj.com)
  • In an earlier study we showed that Cheyne-Stokes respiration was seen in 21% of patients with compensated heart failure, and that these episodes of disordered breathing were associated with blood oxygen desaturation and fragmentation of normal sleep architecture. (bmj.com)
  • In this paper we set out to document the degree of cognitive impairment typically experienced in medically treated stable heart failure of mild to moderate severity. (bmj.com)
  • We recruited 104 patients from a specialist heart failure clinic over a 12 month period. (bmj.com)
  • All patients had compensated heart failure with no change in drug treatment for four weeks. (bmj.com)
  • Cardiovascular magnetic resonance (CMR) has gained an important role in the diagnosis of patients presenting with systolic heart failure. (biomedcentral.com)
  • Patients with end-stage heart failure have poor quality of life and prognosis. (frontiersin.org)
  • End-stage heart failure (NYHA class IV or stage D) is a vastly growing problem, with a poor prognosis and limited therapeutic options. (frontiersin.org)
  • heart failure allowing long-term assistance and an adequate standard of living (Destination Therapy/Bridge to Life). (frontiersin.org)
  • Advanced heart failure is an epidemic contributing considerably to the overall cost of health care in developed nations. (frontiersin.org)
  • End-stage heart failure may present as an acute event or as the terminal stage of a chronic heart disease. (frontiersin.org)
  • In the case of patients with terminal chronic heart failure, the therapeutic procedure is more complex. (frontiersin.org)
  • Although cardiac transplantation remains the gold standard for the treatment of end-stage heart failure, the demand for transplantable hearts exceeds the supply. (hindawi.com)
  • Background A local renin-angiotensin system in the heart is often invoked to explain the beneficial effects of ACE inhibitors in heart failure. (ahajournals.org)
  • Conclusions These data in patients with heart failure support the concept of local angiotensin production in the heart by renin that is taken up from the circulation. (ahajournals.org)
  • Agents that interfere with Ang II formation, the ACE inhibitors in particular, are now widely used for the treatment of hypertension and heart failure. (ahajournals.org)
  • Clinical studies indicate that the beneficial effects of ACE inhibitor treatment in heart failure and left ventricular hypertrophy are not solely determined by the effect of ACE inhibition on systemic arterial pressure. (ahajournals.org)
  • 10 11 12 13 Angiotensinogen mRNA is increased during postinfarction ventricular remodeling in the rat, 11 and ACE mRNA is increased during pressure overload-induced ventricular hypertrophy in the rat 12 and heart failure in humans. (ahajournals.org)
  • 2 4 Most data suggest that the presence of scar is predictive of heart failure rather than sudden cardiac death, but larger unbiased cohort studies are required. (scielo.org.mx)
  • In all three areas, treatments remain suboptimal, particularly in the prevention of progressive heart failure. (scielo.org.mx)
  • However, the range of plasma BNP levels present in the setting of chronic, stable systolic heart failure (HF) is unclear. (ahajournals.org)
  • Plasma B-type natriuretic peptide (BNP) measurement has been established as a helpful aid in the diagnosis of heart failure (HF). (ahajournals.org)
  • She completed a post-doctorate fellowship in heart failure/heart transplantation at Stanford University. (wikipedia.org)
  • Ross specializes in issues related to end-of-life in patients with advanced heart failure, targeting gaps in end-of-life care. (wikipedia.org)
  • In 2006, Ross founded Test Your Limits, an organization that has raised over 2.5 million dollars for heart failure research and included expeditions to Antarctica (2006), Nepal (2008), North Pole (2010), South Pole (2013), Bhutan (2014), Nahanni (2015) and Tibet (2017). (wikipedia.org)
  • Under his influence, the Harefield group was the first group in Europe to implant the Jarvik 2000, in addition to other assist devices as destination therapy or as bridge-to-recovery in case of heart failure. (wikipedia.org)
  • The other 30 to 40% of people develop further symptoms 10 to 30 years after the initial infection, including enlargement of the ventricles of the heart in 20 to 30%, leading to heart failure. (wikipedia.org)
  • Subspecialities include: Those based in the Bernhard Baron Building, also called the Chest Medical Unit: the Respiratory Support and Sleep Centre, providing services for patients with sleep disorders (including common disorders such as obstructive sleep apnea and less common ones such as narcolepsy) and those with ventilatory failure (from conditions such as COPD or neuromuscular disorders including motor neuron disease and poliomyelitis). (wikipedia.org)
  • The valves function becomes affected, which leads to heart failure. (wikipedia.org)
  • According to the Center for Disease Control and Prevention, about 5.1 million people in the United States have heart failure. (wikipedia.org)
  • Approximately half of people who develop heart failure die within five years of diagnosis. (wikipedia.org)
  • In addition, it is estimated that heart failure costs the U.S. $32 billion each year. (wikipedia.org)
  • Play media Restoring adequate blood flow to the heart muscle in people with heart failure and significant coronary artery disease is strongly associated with improved survival, some research showing up to 75% survival rates over 5 years. (wikipedia.org)
  • Manual of Heart Failure Management. (wikipedia.org)
  • Philip Alexander Poole-Wilson FRCP, FESC, FACC, FMedSci (26 April 1943 - 4 March 2009) was a British academic cardiologist of international reputation who had particular interest in the management of heart failure. (wikipedia.org)
  • His research helped to identify the cellular mechanisms behind heart failure and was also important in improving treatment for patients. (wikipedia.org)
  • He was instrumental in raising the profile of heart failure as a major public health problem. (wikipedia.org)
  • Poole-Wilson was interested in heart failure, coronary heart disease and the global prevention of heart disease and stroke. (wikipedia.org)
  • Heart failure was his major research focus and his work covered both basic science (laboratory studies) and clinical research. (wikipedia.org)
  • At the same time his clinical work with George Sutton at Hillingdon Hospital led to them writing a letter to the BMJ highlighting a concern with the prevalence of heart failure in the community. (wikipedia.org)
  • The overall process led to him becoming an expert in the manifestations of heart failure at the cellular, organ, and whole body levels, an expert in designing therapies appropriate for dealing with the symptoms of the disease and an expert in the disease implications for healthcare worldwide. (wikipedia.org)
  • Further research, with others, helped elucidate the body's neurohormonal response in heart failure. (wikipedia.org)
  • This in turn helped development of modern drug therapy for heart failure which has markedly improved the prognosis for patients. (wikipedia.org)
  • He made a major start to the study of muscle changes in heart failure, which he carried on for many years with colleague, Professor Andrew Justin Stewart Coats under the banner "The Muscle Hypothesis" the accepted explanation for the generation of exercise-limiting symptoms in chronic heart failure, but at the time a radical theory. (wikipedia.org)
  • centre
  • Ross is a scientific lead for the Ted Rogers Centre for Heart Research, the director of the Ted Rogers Centre of Excellence in Heart Function and Director of the Cardiac Transplant Program at Toronto General Hospital. (wikipedia.org)
  • Ross began her career in 1996 at Toronto General Hospital's Peter Munk Cardiac Centre. (wikipedia.org)
  • As well as this, it contains an outpatients department, a neo-natal Unit, a burns ward and a burns operating theatre, as well as additional classrooms for the Education Centre, allowing children to continue their education whilst undergoing medium to long term care in the hospital. (wikipedia.org)
  • In March 1986, a charity concert was held called "Heart Beat 86" at the nearby National Exhibition Centre, featuring George Harrison, which raised money for the hospital. (wikipedia.org)
  • Today, Papworth is the UK's largest specialist cardiothoracic hospital and main heart and lung transplant centre. (wikipedia.org)
  • cardiology
  • This principle influenced the guidelines of the international societies of Cardiology, may it be the American College of Cardiology / American Heart Association, or the European Society of Cardiology. (wikipedia.org)
  • cardiology, including coronary angiography and coronary angioplasty, plus facilities for cardiac electrophysiology and catheter ablation, pacemaker insertion, implantable cardiac defibrillator, transcatheter structural heart procedures such as valve implantation intensive care services. (wikipedia.org)
  • In 1982 Poole-Wilson was appointed professor of cardiology at the University of London and then in 1988, he became the British Heart Foundation Simon Marks professor of cardiology at NHLI. (wikipedia.org)
  • method of diagnos
  • A method of diagnosing cardiac transplant rejection within a patient comprising, obtaining a sample of a biological fluid from the patient, and determining the level of a brain natriuretic peptide (BNP) or a fragment thereof, within the sample of body fluid. (google.com.au)
  • 1. A method of diagnosing cardiac transplant rejection episode within a patient comprising, obtaining a sample of a biological fluid from said patient, and determining the level of a brain natriuretic peptide (BNP) or a fragment thereof, within said sample of body fluid, wherein an increase in said level of BNP or fragment thereof is an indication of a rejection episode. (google.com.au)
  • acute
  • Coronary care unit (CCU): Also known as Cardiac Intensive Care Unit (CICU) or Cardiovascular Intensive Care Unit (CVICU), this ICU caters to patients specifically with congenital heart defects or life-threatening acute conditions such as cardiac arrest. (wikipedia.org)
  • The MFI system can detect the onset of arrhythmic and ischemic diseases in a very early stage with high accuracy for both acute and asymptomatic patients. (wikipedia.org)
  • Rarely, young children, or adults may die from the acute disease due to severe inflammation/infection of the heart muscle (myocarditis) or brain (meningoencephalitis). (wikipedia.org)
  • Until the routine use of medications to prevent and treat acute rejection, introduced in 1964, deceased donor transplantation was not performed. (wikipedia.org)
  • uneventful
  • Patients with RVFAC >35% had a relatively uneventful perioperative course and good long-term survival, whereas patients with RVFAC ≤35% had a poor early and late outcome. (ovid.com)
  • patient's
  • The current knowledge about destination therapy and some original data from the DAVID Study (an Italian multicenter prospective study designed to evaluate the patient's survival rate and quality of life of patients implanted with these new devices as long-term support or destination therapy) are summarized herein. (frontiersin.org)
  • post heart transplantation patients As MFI is absolutely risk free and harmless for the patient, the procedure can be repeated without any negative effects for the patient, which gives the cardiologist the opportunity to observe a patient's progressive changes. (wikipedia.org)
  • VADs are distinct from artificial hearts, which are designed to assume cardiac function, and generally require the removal of the patient's heart. (wikipedia.org)
  • implantation
  • Further studies have shown that the evolution of VAD technology has reduced device-related complications and consequently improved survival and quality of life of patients with results, according to some authors, similar to cardiac transplantation at least at 2 years from the implantation. (frontiersin.org)
  • Following BiVAD implantation, the patient developed severe hemolysis, with plasma hemoglobin levels peaking at 595 mg/dL (Figure 1 ) on the third postoperative day and a total bilirubin reaching 13.1 mg/dL (Figure 2 ). (hindawi.com)
  • A worldwide shortage of organs for clinical implantation causes about 20-35% of patients who need replacement organs to die on the waiting list. (wikipedia.org)
  • The first successful long-term implantation of an artificial LVAD was conducted in 1988 by Dr. William F. Bernhard of Boston Children's Hospital Medical Center and Thermedics, Inc of Woburn, MA under a National Institutes of Health (NIH) research contract which developed Heart-mate, an electronically controlled assist device. (wikipedia.org)
  • clinical
  • The purpose of this pilot trial is to determine the feasibility of a large, multi-center randomized clinical trial aimed to test whether a treatment strategy of percutaneous catheter ablation of ventricular tachycardia (VT) is superior to state-of-the-art pharmacologic therapy at reducing all-cause mortality in patients with an implantable cardioverter defibrillator (ICD) who receive therapy for VT in the absence of any reversible cause. (clinicaltrials.gov)
  • 1 Hence, there is extensive use of these Clinical Perspective p 66 agents for patients in a variety of settings. (ahajournals.org)
  • The objective of this study is to examine the prevalence, clinical characteristics, and predictors of "normal" plasma BNP levels in symptomatic patients with HF in the clinical practice setting. (ahajournals.org)
  • As part of routine care, all patients underwent diagnostic evaluation to establish the diagnosis of HF and to determine the severity (by echocardiogram and clinical history) and the underlying pathogenesis (by stress testing with perfusion imaging and/or coronary angiography) of HF. (ahajournals.org)
  • For patients without NYHA documentation in the clinical notes, 2 collaborating investigators of the study who were blinded to the results (J.P.G., M.J.L.) retrospectively reviewed the description of functional status from the clinical notes at the time of BNP testing to assign the corresponding NYHA class. (ahajournals.org)
  • Cardiomag Imaging, Inc.) . Through clinical research in Europe, Asia and the U.S.(see publications in footnotes), MCG has been proven to have practical application for diagnosis of cardiac disease, and has become the clinically predominant application for recording the heart's magnetic signals. (wikipedia.org)
  • Mesoblast said they were in the process of completing an Investigational New Drug (IND) submission to the United States FDA to commence Phase 2 clinical trials in patients with low back pain due to disc degenerative disease. (wikipedia.org)
  • mitral
  • In 2003, he presented a research paper at the AATS annual meeting with a study population of 311 patients, divided in two subgroups: one underwent isolated mitral valve repair, the other mitral valve repair associated to tricuspid valve repair. (wikipedia.org)
  • Patient had coronary artery disease and severe mitral valve leak. (wikipedia.org)
  • However, operations on the heart valves were unknown until, in 1925, Henry Souttar operated successfully on a young woman with mitral valve stenosis. (wikipedia.org)
  • neonatal
  • Hospitals may have ICUs that cater to a specific medical speciality or patient, such as those listed below: Neonatal intensive care unit (NICU). (wikipedia.org)
  • This specialty unit cares for neonatal patients who have not left the hospital after birth. (wikipedia.org)
  • biopsies
  • Biopsies from patients with ARVC consistently show abnormalities in intercalated discs, with decreased numbers of desmosomes and widening of intercellular gaps between adjacent cardiomyocytes, suggesting that this disease is a disease of intercalated discs. (wikipedia.org)
  • Methods
  • Methods and Results- Under physiological conditions (37°C, pH 7.35, 1.25 mmol/L Ca 2+ ), there was a dose-dependent decrease in contractile force in ventricular trabeculae isolated from end-stage failing human hearts superfused with pantoprazole. (ahajournals.org)
  • echocardiography
  • We describe the use of transesophageal echocardiography to monitor hemodynamic changes induced by laparoscopic for cholecystectomy in a patient with transplanted heart. (asahq.org)
  • Hypoplastic left heart syndrome can be diagnosed prenatally or after birth via echocardiography. (wikipedia.org)
  • Echocardiography is a non-invasive method of quantifying cardiac output using ultrasound. (wikipedia.org)