Patients undergoing radiotherapy radiotherapy or concurrent chemoradiotherapy. Medical search. Frequent questions

1 Early clinical studies of the EGFR monoclonal antibody in combination with radiotherapy primarily included head and neck squamous cell carcinoma, and the study of its combination with radiation therapy for NSCLC was performed relatively late. (dovepress.com)
Methods - A cohort of patients treated for head and neck squamous cell carcinoma was developed using administrative data. (ices.on.ca)
Between January 2000 and July 2014, a total of 158 women with cervical squamous cell carcinoma were treated with radiotherapy with or without concurrent chemotherapy at our department. (koreamed.org)
C. C. Wang, C. H. Lai, Y. T. Huang, A. C. Chao, H. H. Chou and J. H. Hong* HPV genotypes predict survival benefits from concurrent chemotherapy and radiation therapy in advanced squamous cell carcinoma of the cervix. (cgmh.org.tw)
Sarcopenia as a Predictor of Neoadjuvant Therapy-Related Toxicity in Esophageal Squamous Cell Carcinoma Patients. (medline.ch)
Prediction of Response to Neoadjuvant Chemoradiotherapy Combined with Pembrolizumab in Esophageal Squamous Cell Carcinoma with CT/FDG PET Radiomic Signatures Based on Machine Learning Classification. (medline.ch)
Chemoradiotherapy Combined with Nab-Paclitaxel plus Cisplatin in Patients with Locally Advanced Borderline Resectable or Unresectable Esophageal Squamous Cell Carcinoma: A Phase I/II Study. (medline.ch)
The diagnosis of cervical squamous cell carcinoma with concurrent T-cell rich B-cell lymphoma in dissected lymph nodes has not been reported to our knowledge. (bmj.com)
This study aimed to investigate the oncologic outcomes and prognostic factors of salvage treatments in patients with recurrent oropharyngeal squamous cell carcinoma (OPSCC) after radiotherapy (RT)-based treatment. (e-crt.org)
A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
whether their expression is associated with clinicopathological factors and prognosis in patients of esophageal squamous cell carcinoma (ESCC) is still under investigation. (gastrores.org)

The number of unplanned hospitalizations or ED visits (per 100 patient days) were 0.69 for surgery, 0.78 for surgery followed by concurrent chemoradiotherapy (CCRT), 0.55 for surgery followed by radiotherapy, 0.86 for CCRT, and 0.50 for radiation. (ices.on.ca)
Patients receiving CCRT had a statistically higher likelihood of treatment period events. (ices.on.ca)
Rates are higher in patients receiving CCRT. (ices.on.ca)
This study investigated treatment outcomes and prognostic factors of survival in CEC patients undergoing definitive radiotherapy or concurrent chemoradiotherapy (CCRT). (bvsalud.org)
To compare patient survival outcomes between completion hysterectomy and conventional surveillance in locally advanced adenocarcinoma of the cervix after concurrent chemoradiotherapy (CCRT). (koreamed.org)
Patients with adenocarcinoma of the cervix after CCRT were identified in a tertiary academic center database from 2004 to 2018. (koreamed.org)
Patients received completion hysterectomy or surveillance after CCRT. (koreamed.org)
A total of 78 patients were assigned to completion surgery and 97 to surveillance after CCRT. (koreamed.org)
Patients age less than 60, tumor size over 4 cm, stage IIB and persistent residual disease after CCRT were most likely to benefit from hysterectomy. (koreamed.org)
For advanced diseases, CRT shows a better prognosis than RT alone, especially sequential CRT and concurrent chemoradiotherapy (CCRT) [ 5 - 7 ]. (e-crt.org)
In particular, studies reported higher survival rates in patients undergoing CCRT than sequential CRT [ 6 , 7 ]. (e-crt.org)
Unlike substantial evidence in the prevention of chemotherapy-induced nausea and vomiting (CINV), research in the prevention of nausea and vomiting caused by concurrent chemoradiotherapy (CCRT) is currently lacking," Sun Yat-Sen University researchers wrote in the JAMA Network Open study, which they posited was to their knowledge, "the first study to assess the efficacy and safety of fosaprepitant during combined radiotherapy-HEC. (curetoday.com)
The study's primary endpoint of complete response (no vomiting or rescue therapy during CCRT) was reached by 20.4% of patients receiving weekly fosaprepitant and 12.5% of patients who received fosaprepitant every three weeks. (curetoday.com)
In the absence of similar research, we endeavored to investigate the prognostic usefulness of posttreatment neutrophil-to-lymphocyte ratio (NLR) in patients treated with definitive concurrent chemoradiotherapy (CCRT) for locally advanced pancreatic adenocarcinoma (LAPAC). (hindawi.com)
Our retrospective research included a sum of 126 LAPAC patients who received CCRT. (hindawi.com)
The NLR was calculated for each patient based on the complete blood count test results obtained on the last day of the CCRT. (hindawi.com)
The present study found that the posttreatment NLR ≥3.1 was independently linked with a higher risk of DM and subsequent degraded survival outcomes in unresectable LAPAC patients managed with exclusive CCRT. (hindawi.com)
however, chemotherapy (CT), concurrent chemoradiotherapy (CCRT), and induction CT followed by CCRT are the most often utilized alternatives [ 6 ]. (hindawi.com)
This study aimed to evaluate whether prophylactic extended-field pelvic radiotherapy (EF-PRT) yields better results than standard whole pelvic radiotherapy (WPRT) in patients with pelvic lymph node-positive cervical cancer treated with concurrent chemoradiotherapy (CCRT). (e-roj.org)
In this study, prophylactic radiotherapy for PALN does not have an additional benefit in patients with pelvic lymph node-positive cervical cancer treated with CCRT. (e-roj.org)

UK Cancer Centre experience of hysterectomy post chemo-radiotherapy treatment for cervical cancer. (koreamed.org)
Six cycles of CHOP (cyclophosphamide, adriamycin, vincristine, and prednisone) chemotherapy for the lymphoma and concomitant pelvic chemo-radiotherapy with cisplatin for cervical cancer were given. (bmj.com)
Aim: The main objective of this study was evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy receiving concurrent chemo radiotherapy for evaluation of the response of treatment,toxicity profile and quality of life of both radiotherapy treatment modalities. (oncologyradiotherapy.com)
Concurrent chemo-radiotherapy is the usual treatment for locally advanced cervical cancer. (oncologyradiotherapy.com)
Evaluation of bone marrow sparing IMRT versus standard IMRT as a planning limitation in cervical cancer therapy cases receiving concurrent chemo radiotherapy. (oncologyradiotherapy.com)

Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy? (biomedcentral.com)
Intensity Modulated Radiotherapy (IMRT)for Whole Pelvic Radiation Therapy (WPRT) is considered superior to 3D conformal radiotherapy in dose distribution to targets and to spare normal tissue as (BM) supported by many dosimetric studies [ 7 ]. (oncologyradiotherapy.com)

In this propensity-score-matched, population-based cohort study, we investigated the survival effects of pretreatment 8-fluorodeoxyglucose positron emission tomography-computed tomography ( 18 FDG-PET-CT) on patients with NPC. (nih.gov)
Pretreatment 18 FDG-PET-CT is associated with longer survival in patients with clinical stage II-IVA NPC but not in stage I NPC. (nih.gov)
After 2 years, researchers found no significant differences in overall and disease-free survival between patients on active surveillance and those who received surgery either immediately following neoadjuvant chemoradiotherapy or who switched from active surveillance to surgery. (medscape.com)
Overall, patients who underwent active surveillance had "noninferior overall survival at 2 years," said Berend J. Van der Wilk, PhD candidate, Erasmus Medical Center, Erasmus University, Rotterdam, the Netherlands, who presented the findings at the European Society for Medical Oncology (ESMO) Annual Meeting 2023 on October 20. (medscape.com)
The potential pitfalls of an active surveillance approach is that patients may develop unresectable tumor regrowths, "possibly resulting in inferior overall survival. (medscape.com)
The aim of this retrospective study was to investigate the general characteristics and survival of our patients receiving CRT. (yyu.edu.tr)
We compared the progression-free survival (PFS) and overall survival (OS) between the patients with or without adjuvant hysterectomy. (koreamed.org)
The reason why performing the SCC-Ag test during post-treatment surveillance is not recommended for asymptomatic patients is that the survival benefit of post-recurrence salvage therapy is still uncertain, except for surgery for central pelvic recurrence after primary radiotherapy [ 8 9 ]. (koreamed.org)
In theory, ERKD is predicted to improve survival of GBM patients simply by restricting tumors of glucose, while providing necessary metabolic fuel in the form of ketones to support vital organs including the brain. (biomedcentral.com)
Of the 10-20% of patients who present with resectable tumors, the 5-year surviva rate is still only about 20%, with a median survival of around 23-43 months with adjuvant therapy ( 2 - 4 ). (iiarjournals.org)
This study was done to identify the influence of pre-treatment inflammatory biomarkers on survival in patients treated with radical chemo-radiation or radiation. (waocp.com)
Hence, we conducted this prospective observational study to identify the effect of pre-treatment inflammatory biomarkers on survival in cervical cancer patients treated by radical radiotherapy or chemo-radiation. (waocp.com)
The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. (cancernetwork.com)
Even among patients who present with localized disease, the 5-year overall survival (OS) is approximately 20%, but potentially higher in patients with complete surgical resection (R0) and uninvolved lymph nodes. (cancernetwork.com)
Despite rigorous therapy, the estimated median survival time of such patients is only around 12 months [ 7 ], and 70% of all cases die as a result of extensive distant metastases (DM) [ 8 ]. (hindawi.com)
In addition, prognostic indicators of recurrence-free survival (RFS) and overall survival (OS) were identified in patients who underwent salvage treatment. (e-crt.org)
[ 36 ] However, a recent phase II trial of sunitinib maintenance therapy in patients with untreated extensive-stage SCLC reported a modest but significant improvement in median progression-free survival, from 2.1 months with placebo to 3.7 months with sunitinib. (medscape.com)
At univariate analysis, the overall survival received benefit from Karnofsky performance status (KPS) $80, three-dimensional conformal radiotherapy, total dose more 60 Gy and ATM 81165C allele. (coek.info)
Delays in surgery for esophageal cancer did not appear to have much impact on patients' relative survival for early-stage cancer compared with patients who had surgery early, but they did reduce the relative survival rate by almost half for patients with more advanced disease, according to an. (ascopost.com)
In the phase III RATIONALE-302 trial reported in the Journal of Clinical Oncology, Shen et al found that the anti-PD-1 antibody tislelizumab significantly improved overall survival vs chemotherapy in the second-line treatment of patients with advanced or metastatic esophageal squamous cell. (ascopost.com)
A phase III randomized trial reported that elective PALN radiotherapy can reduce paraaortic recurrence in these patients and improve survival [ 11 , 12 ]. (e-roj.org)
Favorable long-term survival following induction chemotherapy with cisplatin, fluorouracil, and leucovorin and concomitant chemoradiotherapy for locally advanced head and neck cancer. (uchicago.edu)
Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. (uchicago.edu)
initially reported that the 4-year local progression free survival rate for NPC after IMRT was 97% (in 67 patients, 70% of whom had stage III-IV disease) [ 6 ]. (biomedcentral.com)
The patients who underwent conversion complete radical surgery showed good long-term survival outcomes, with an overall survival time of 29.4-48.8 months and progression-free survival time of 14.7-41.1 months. (kjco.org)
Short-course RT followed by systemic chemotherapy could provide patients with unresectable stage IV rectal cancer a chance to undergo to conversion radical surgery with good long-term survival outcomes. (kjco.org)
Fourteen patients underwent CS (30.4%), and patients who underwent CS had significantly better overall survival than those who did not undergo surgery (p=0.0291). (iiarjournals.org)
To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. (springer.com)
From a biological point of view, there are arguments to support an early as well as a late initiation of RT: οn the one hand, an early start of RT could have a negative impact on survival due to reduced radiosensitivity secondary to postoperative hypoxia or due to the "second-impact" effect leading to a further deterioration of the clinical condition of an already compromised patient [ 19 , 20 ]. (springer.com)
Studies addressing the effect of timing of RT on survival suffer from considerable bias, such as inhomogeneous patient populations, inhomogenous treatment protocols or disregard for tumor location, EOR, and RTV. (springer.com)
Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)

Long-Term Results of a Phase II Study of Accelerated Hyperfractionated Thoracic Radiotherapy with Dose Escalation to 54 Gy for Limited-Stage Small-Cell Lung Cancer. (medline.ch)
Materials/Methods: 105 non-small cell lung cancer who were inoperable and underwent thoracic radiotherapy at the Cancer Hospital of Peking Union Medical College (PUMC) and Chinese Academy of Medical Sciences (CAMS) between January 2004 and August 2006 were evaluated. (coek.info)

Hysterectomy specimens revealed 64.1% (50/78) of the patients had pathologic residual tumor. (koreamed.org)
However, both patients showed tumor progression while on the ERKD therapy. (biomedcentral.com)
IVIM-DWI could efficiently assess tumor treatment response to fractional radiotherapy and predict the radio-sensitivity for NPCs. (e-crt.org)
However, there are limited effective non-invasive image modalities for the early prediction of tumor response to chemoradiotherapy (CRT). (e-crt.org)
B.S. Huang, N.M. Tsang, S.M. Lin, D. Y. Lin, J. M. Lien, C. C. Lin, W. T. Chen, W.Y. Chen, J. H. Hong* High-dose hypofractionated X-ray radiotherapy for hepatocellular carcinoma: Tumor responses and toxicities. (cgmh.org.tw)
Planning Considerations for the Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Radiotherapy for Locally-Advanced Non-Small Cell Lung Cancer. (medline.ch)
Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
The agent demonstrated acceptable tolerability and durable clinical activity in patients with multiple advanced tumor types, including in those with pretreated endometrial cancer. (onclive.com)
The purpose of this study was to evaluate the prognostic value of maximum primary tumor diameter (MPTD) in patients with nasopharyngeal carcinoma (NPC) treated using IMRT. (biomedcentral.com)
This combination of chemotherapy and radiotherapy has a special role in tumor down staging and in sphincter preservation for lower rectal tumors. (wjgnet.com)
Although the tumor was considered to have been fully resected and had not spread to any nodes, the patient died of recurrent cancer within 1 year. (medscape.com)
Three patients experienced two histologic changes, which the changed tumors returned to its original subtype or changed to a combined tumor after treatments. (e-crt.org)
The standard of care for patients with newly diagnosed GBM comprises maximum safe resection of the tumor followed by radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy [ 3 , 4 ]. (springer.com)
The purpose of this study was to evaluate the timing of RT as a prognostic factor on a homogeneous patient population with only newly diagnosed primary GBM treated with the same treatment scheme, also taking important prognostic factors such as tumor location, MGMT methylation status, EOR and RTV into account. (springer.com)
We retrospectively analyzed all adult patients with a newly diagnosed primary GBM treated according to the EORTC 22981/26981 protocol [ 3 ] at the Brain Tumor Center of the University Hospital of Cologne, Germany between 2010 and 2015. (springer.com)
Generalized least squares (GLS) regression was utilized to predict MTV-voxel midRT-SUV from patient-level (tumor etiology, MTV preRT-SUVáµ?áµ‰áµƒâ? (aapm.org)
Over 19 patients and 8516 voxels, MTV-voxel SUV decreased from 6.3 g/mL to 3.6 g/mL at midRT-PET on average, with large inter-patient (standard deviation [SD]: 2.9 g/mL) and intra-tumor variability (SD: 1.7 g/mL). (aapm.org)
The multiscale model can be extended to predict post-treatment tumor response and normal tissue functional changes, and forms the basis to inversely optimize spatial-temporal dose distributions for precision radiotherapy. (aapm.org)

Prognostic factors and morbidities after completion surgery in patients undergoing initial chemoradiation therapy for locally advanced cervical cancer. (koreamed.org)
Patients and Methods: We conducted a retrospective study of 63 patients diagnosed from 2004-2013 with histopathologically-confirmed stage I/II pancreatic cancer treated with a surgical resection followed by adjuvant concurrent chemoradiation to at least 45 Gy using 3D planning and capecitabine at 1,600 mg/m 2 /day (Monday-Friday) for 6 weeks. (iiarjournals.org)
Conclusion: Concurrent chemoradiation using capecitabine as a radiosensitizer in the adjuvant setting for pancreatic cancer was completed by the vast majority of patients in this series. (iiarjournals.org)
Patients with a CRP-Albumin ratio of more than 0.8 are at significant risk of relapse and death after chemoradiation or radiation. (waocp.com)
Machine Learning-Based Prediction of Hospitalization Using Daily Step Counts for Patients Undergoing Chemoradiation was presented at the 2022 ASTRO Annual Meeting. (roinstitute.org)
Cardiac Dosing Predicts Activity Decline During Concurrent Chemoradiation for Locally Advanced Lung Cancer was presented at the 2018 ASTRO Annual Meeting. (roinstitute.org)

Methods Between 2001 and 2011, we treated 207 patients with resectable pharyngeal cancer, including 98 patients with oropharyngeal cancer (OPC) and 109 patients with hypopharyngeal cancer (HPC) who received definitive RT or CRT. (elsevierpure.com)
Patients and Methods: Forty-six patients with cT4b esophageal cancer, including borderline cT4b lesions, were eligible. (iiarjournals.org)

MADRID - More than one third of patients with locally advanced esophageal cancer who have a complete clinical response to neoadjuvant chemoradiotherapy may be able to safely avoid major surgery, findings from the Dutch SANO-trial suggest. (medscape.com)
Develop a Deep Radiomics Model for Predicting the Response to Neoadjuvant Chemoradiotherapy (nCRT) in Patients with Locally Advanced Esophageal Cancer Using Three-Stage Longitudinal CT Images. (medline.ch)

Patient received single fraction radiation and underwent percutaneous nephrostomy. (jpalliativecare.com)
Ninety-one CEC patients were treated by intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3DCRT) between July 2007 and September 2017. (bvsalud.org)
We aimed to evaluate the safety and efficacy of adding capecitabine (a known radiosensitizer by direct and abscopal effects) to concurrent radiation in the adjuvant setting after resection of pancreatic adenocarcinoma. (iiarjournals.org)
In addition, as seen in other disease sites (head and neck cancer, sarcoma), postoperative radiation for patients with incompletely resected malignancies continues to play an important role ( 6 ). (iiarjournals.org)
Selected patients with advanced or metastatic disease may receive additional therapy (radiation or neck dissection) depending on their response to first-line therapy. (medscape.com)
Patients with biopsy proven carcinoma cervix treated with Radiotherapy or Chemo-radiation from January 1st, 2016 to September 30th, 2017 were included. (waocp.com)
But in advanced cases, patients are treated by radical chemo-radiation and hence these adverse pathological features cannot be determined. (waocp.com)
Effect of Segmental Abutting Esophagus-Sparing Technique to Reduce Severe Esophagitis in Limited-Stage Small-Cell Lung Cancer Patients Treated with Concurrent Hypofractionated Thoracic Radiation and Chemotherapy. (medline.ch)
Daily Adaptive vs. Non-Adaptive External Beam Radiation Therapy with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer (NSCLC): A Prospective Randomized Trial of an Individualized Approach for Toxicity Reduction (ARTIA-Lung). (medline.ch)
In the CRT arm, there were issues of compliance, with 32% of patients assigned to CRT receiving inappropriate radiation and 25% of patients failing to initiate treatment within 10 weeks post surgery, the protocol-specified time limit. (cancernetwork.com)
In recurrent OPSCC after RT-based treatment, successful salvage was achieved in 56.4% patients who had undergone salvage surgery and radiation treatment. (e-crt.org)
For the approximately 30% of patients with SCLC who have limited-stage disease at the time of diagnosis (ie, tumors confined to the hemithorax of origin, the mediastinum, or the supraclavicular lymph nodes), management typically involves combination platinum-based chemotherapy and thoracic radiation therapy given with curative intent. (medscape.com)
Purpose/Objective(s): Institutional experience over the 10-year period of the use of hyperfractionated radiation therapy (Hfx RT) with or without concurrent chemotherapy (CHT) in stage III non-small cell lung cancer (NSCLC) was reviewed. (coek.info)
Results from their pilot study suggested that step counts may serve as dynamic predictors of short-term hospitalization risk during chemoradiotherapy, and with his Innovative Projects in Radiation Oncology award, Dr. Ohri explored whether physical activity could also be used as a treatment. (roinstitute.org)
Over half of cancer patients undergo radiation therapy (RT). (nature.com)

Out of 91 patients, 34 received concurrent cisplatin-based chemotherapy (CT) including 18 patients who also received neoadjuvant CT. (bvsalud.org)
All patients received concurrent cisplatin-based chemotherapy. (e-roj.org)

Can Some Patients With Esophageal Cancer Avoid Surgery? (medscape.com)
To compare active surveillance with standard surgery, the team conducted a phase 3 noninferiority stepped-wedge cluster randomized trial involving patients with locally advanced esophageal cancer. (medscape.com)
Insurance Request and Approval Process for Proton Beam Therapy in Patients with Esophageal Cancer. (medline.ch)
Using whole-genome sequencing to contrast genomic alterations in patients with stable Barrett's esophagus compared to patients whose Barrett's progressed to esophageal adenocarcinoma, Paulson et al reported that DNA changes presaging esophageal cancer can be spotted years before cancer develops. (ascopost.com)
Background/Aim: This study analyzed the outcomes of docetaxel, cisplatin, and 5-fluorouracil (DCF) therapy and DCF plus concurrent radiotherapy (DCF-RT), both followed by conversion surgery, if possible, in patients with cT4b esophageal cancer. (iiarjournals.org)
We reviewed 100 consecutive patients who underwent thoracoscopic esophagectomy with gastric tube reconstruction and placement of a jejunostomy feeding catheter for esophageal cancer. (biomedcentral.com)
This was a retrospective observational study of 100 consecutive patients who underwent TSE for esophageal cancer, followed by gastric tube reconstruction, with placement of a jejunostomy feeding catheter, at our institution, between July 2009 and May 2017. (biomedcentral.com)

Continuous infusion paclitaxel, 5-fluorouracil, and hydroxyurea with concomitant radiotherapy in patients with advanced or recurrent head and neck cancer. (uchicago.edu)
Perspectives on combination chemotherapy with concomitant radiotherapy for poor-prognosis head and neck cancer. (uchicago.edu)
Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. (uchicago.edu)
Neoadjuvant PFL augmented by methotrexate and piritrexim followed by concomitant chemoradiotherapy for advanced head and neck cancer: a feasible and active approach. (uchicago.edu)
A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)

Patients received neoadjuvant chemoradiotherapy with carboplatin and paclitaxel for 5 weeks. (medscape.com)
Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer. (cancernetwork.com)
Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer. (uchicago.edu)

In patients who had taken definitive CRT, average 50.4 Cy (1.8 Gy/fx/day) dose was given. (yyu.edu.tr)
Objectives/Hypothesis Local residual or recurrent pharyngeal cancer after definitive radiotherapy (RT) or chemoradiotherapy (CRT) is correlated to poor prognosis. (elsevierpure.com)
A cancer registry was used to retrieve the records of 337 patients treated with definitive RT or concurrent chemoradiotherapy (CRT) from 2008 to 2018 at a single institution. (e-crt.org)
The other 10 patients failed to receive a definitive resection because of unresectable disease. (biomedcentral.com)

1 - 3 In patients with node-negative small tumors, chemotherapy burden can be de-escalated by administering weekly paclitaxel for 3 months and concurrent trastuzumab for 1 year. (jnccn.org)
The patients had primary rectal tumors involving the MRF and unresectable distant metastases. (kjco.org)
Daily Step Counts to Predict Hospitalizations During Concurrent Chemoradiotherapy for Solid Tumors was presented at the 2019 ASCO Quality Care Symposium. (roinstitute.org)
E-mail: [email protected] ular and histological features of tumors and clinical characteristics of patients. (bvsalud.org)

Patients with nasopharyngeal carcinoma treated with concurrent chemoradiotherapy reported higher quality of life and were less likely to experience vomiting when receiving fosaprepitant every week as opposed to every three weeks. (curetoday.com)

Long-course radiotherapy (RT) with concurrent systemic chemotherapy followed by total mesorectal excision after 6-10 weeks is a standard treatment for patients with locally advanced mid-to-low rectal cancer [ 1 ]. (kjco.org)

In preclinical experiments, effective drug therapies for curative modalities are under investigation for pancreatic cancer patients. (yyu.edu.tr)
Role of microRNA (miRNA) in identifying the patients of ESCC and monitoring the response to treatment modalities like chemotherapy, radiotherapy and chemoradiotherapy (CRT) is recently emerging. (gastrores.org)

All patients underwent curative resection of pancreatic adenocarcinoma without evidence of intraperitoneal disease. (cancernetwork.com)

This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer. (biomedcentral.com)
Curative treatment is challenging in patients with locally advanced rectal cancer and unresectable metastases. (kjco.org)
The aim of this study was to evaluate the clinical outcomes of short-course radiotherapy (RT) followed by systemic chemotherapy for patients with rectal cancer with mesorectal fascia (MRF) involvement and unresectable distant metastases. (kjco.org)
The study included consecutive patients diagnosed as having metastatic mid-to-low rectal cancer treated with short-course RT followed by systemic chemotherapy for conversion radical or palliative surgery between 2014 and 2019 at Gil Medical Center. (kjco.org)
However, no optimal treatment has been established yet for patients with initially unresectable metastatic rectal cancer [ 2 ]. (kjco.org)
Information from this questionnaire collected from you and other patients may help improve the quality of life of rectal cancer patients in the future. (stanford.edu)

As adjuvant treatment dose, 45 Cy (1,8 Gy/fx/day) radiotherapy was administered to pancreas and regional lymph nodes. (yyu.edu.tr)
In 2016 single-dose injectable Emend, when combined with other drugs treating nausea and vomiting, was approved by the FDA to prevent delayed CINV in patients who'd received moderately emetogenic chemotherapy (MEC). (curetoday.com)
Irradiation Dose to the Swallowing Muscles Impacts Nutritional Status in Head and Neck Cancer Patients: The Prospective Randomized HEADNUT Trial. (medline.ch)
Split-course radiotherapy (RT) was administered to a total dose of 40 Gy, with a 2-week treatment break. (cancernetwork.com)
The median dose to the PALN area in patients treated with EF-PRT was 45 Gy. (e-roj.org)
Patient characteristics and irradiated dose were not significantly different, except the dose to the para-aortic area, between the two groups. (e-roj.org)
Ninety-five percent patients completed a full-dose chemoradiotherapy as planning. (biomedcentral.com)
Patients enrolled to cohort H of the study received retifanlimab at a dose of 500 mg every 4 weeks. (onclive.com)
To assess dose-limiting toxicities (DLTs) of capecitabine +/- oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 2. (stanford.edu)
To determine the maximum-tolerated dose (MTD) when capecitabine - oxaliplatin in a combination regimen with capecitabine and radiotherapy (Phase 1) 3. (stanford.edu)

Over the 2-year follow-up, at least 35% of patients on active surveillance were spared surgery. (medscape.com)
Patients on active surveillance who experienced locoregional regrowth could still undergo surgery, Van der Wilk said. (medscape.com)
Van der Wilk said those strong outcomes create some uncertainty as to whether all patients need standard surgery after chemoradiotherapy. (medscape.com)
More than 300 patients who achieved a complete clinical response 12 weeks after completing chemoradiotherapy were randomly assigned to undergo standard surgery or active surveillance. (medscape.com)
Overall, 198 patients underwent active surveillance, and 111 patients underwent standard surgery. (medscape.com)
Overall, 101 of 111 patients in the standard surgery arm and 83 of 198 (42%) in the active surveillance group had surgery. (medscape.com)
5. Platt SL, Patel A, Humphrey PJ, Al-Booz H, Bailey J. Completion surgery after chemoradiotherapy for cervical cancer - is there a role? (koreamed.org)
Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. (koreamed.org)
The primary therapy for early stage cervical cancer is surgery and that for locally advanced disease is concurrent chemoradiotherapy. (koreamed.org)
We analyzed the efficacy of salvage surgery for patients with local residual or recurrent pharyngeal cancer after RT or CRT. (elsevierpure.com)
24 with HPC) underwent salvage surgery. (elsevierpure.com)
At present, combined modality treatment (chemotherapy followed by surgery or radio-/chemotherapy) for patients with locally advanced non-small-cell lung cancer (NSCLC) is being studied extensively. (biomedcentral.com)
Radical Chemoradiotherapy vs. Radical Surgery plus Adjuvant Chemotherapy or Chemoradiotherapy in Locally Advanced Primary Small Cell Carcinoma of the Esophagus: A Multicenter Retrospective Study in China. (medline.ch)
Forty-three patients were enrolled in this clinical trial comparing outcomes of surgery alone to CRT. (cancernetwork.com)
Of these, 63 patients received salvage treatment (surgery 57.2%, re-(C)RT 23.8%, and chemotherapy 19.0%), and the salvage success rate was 47.6% at the last follow-up. (e-crt.org)
Salvage surgery patients with negative resection margins had better oncologic outcomes than those with close/positive resection margins. (e-crt.org)
However, successful application of organ preservation protocols in advanced laryngopharyngeal cancer treatment has led to increased utilization of upfront RT or chemoradiotherapy (CRT) over upfront surgery in OPSCC management [ 3 , 4 ]. (e-crt.org)
Then 53 and 57 patients received a radical surgery, and 8 and 14 cases were confirmed as ypCR in two groups ( P = 0.157). (biomedcentral.com)
During the median follow-up period of 29.4 months, three patients underwent conversion radical surgery with R0 resection, two underwent palliative surgery, and two could not undergo surgery. (kjco.org)
The incidence of BOFJ was evaluated and the change in body weight after surgery was compared between patients with and without BOFJ. (biomedcentral.com)
SqCa in a patient treated with surgery was changed into combined AdenoCa and SqCa. (e-crt.org)
RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery. (springer.com)
The laparoscopic approach for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (L-CRS + HIPEC) in highly selected patients was previously reported from the PSOGI registry with a demonstrable reduction in length of stay and post-operative morbidity. (unav.edu)
The purpose of this study is to determine whether the gentamicin-collagen sponge is safe and effective for preventing surgical wound infections in patients undergoing colorectal surgery. (stanford.edu)
Chemotherapy and/or radiotherapy are frequently given before or after surgery. (stanford.edu)
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)

Conclusions - Patients undergoing treatment for head and neck cancer have significant unplanned hospitalizations and visits to the emergency department in the treatment period. (ices.on.ca)
Measurement of functional outcomes in head and neck cancer patients. (mdanderson.org)

87.5% (456/521) of patients with Stage T3-T4/N1-N3 disease also received cisplatin-based chemotherapy. (biomedcentral.com)

1. Kokka F, Bryant A, Brockbank E, Powell M, Oram D. Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer. (koreamed.org)
As such, prophylactic extended-field pelvic radiotherapy (EF-PRT), including the para-aortic region, has been suggested to treat occult metastases in locally advanced cervical cancer, particularly in patients with pelvic LN involvement. (e-roj.org)

During post-treatment surveillance, 53 patients were diagnosed as having recurrent cervical cancer based on biopsy or a radiological test showing progression of a lesion. (koreamed.org)
The poor-responder group (PRG) was defined as patients with residual or recurrent disease after primary treatment, and the oncologic outcomes for each salvage treatment method were analyzed. (e-crt.org)
Retifanlimab demonstrated encouraging antitumor activity with favorable tolerability in patients with recurrent microsatellite instability-high or mismatch repair deficient endometrial cancer, according to data from the phase 1 POD1UM-101 trial. (onclive.com)
Retifanlimab (INCMGA 0012) demonstrated encouraging antitumor activity with favorable tolerability in patients with recurrent microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) endometrial cancer, according to data from the phase 1 POD1UM-101 trial (NCT03059823), presented during the 2021 SITC Annual Meeting . (onclive.com)
Limited treatment options are available to patients with recurrent or metastatic endometrial cancer. (onclive.com)
Data from a preplanned interim analysis of the trial showed that the agent had promising activity specifically in patients with recurrent MSI-H or dMMR endometrial cancer. (onclive.com)
In the analysis featured in the poster, investigators shared the results regarding the safety and clinical activity of retifanlimab in patients with MSI-H or dMMR recurrent endometrial cancer, which was cohort H of the POD1UM-101 study. (onclive.com)
The trial enrolled patients who were at least 18 years of age with histologically proven, unresectable recurrent endometrial cancer that was MSI-H or dMMR based on local testing. (onclive.com)
Therefore, ESCC must be detected at an early stage, and recurrent disease must be diagnosed when it is clinically occult, in order to improve the prognosis of patients with ESCC. (gastrores.org)

After initial (C)RT, the PRG comprised 71 of the 337 patients (21.1%): 18 patients had residual disease, and 53 had recurrence after primary treatment (mean time to recurrence 19.5 months). (e-crt.org)

The identification of these inflammatory biomarkers is a cost-effective method of identifying patients at high risk of recurrence after radical treatment for carcinoma cervix, especially in a developing country like India. (waocp.com)

Neuropathological diagnosis was performed in accordance with the 2016 WHO classification and patients with a mutation encoding for the isocitrate dehydrogenase (IDH) were not included, since they most probably represented secondary GBM with a completely different prognosis [ 23 , 24 ]. (springer.com)

MPTD was an independent prognostic factor in patients with NPC treated using IMRT, and significantly improved the prognostic value of the current T classification criteria for NPC. (biomedcentral.com)

Aim: Pancreatic cancer is a highly lethal malignancy and in locally advanced disease, chemotherapy (CT) or chemoradiotherapy (CRT) are implemented. (yyu.edu.tr)
Material and Method: Between the years 2009-2013, 62 pancreatic cancer patients were taken into study who admitted to Van Training and Research Hospital. (yyu.edu.tr)
Discussion: According to our single center experience, our data in pancreatic cancer patients were parallel with international data. (yyu.edu.tr)
Eight patients with non-small-cell lung cancer underwent PET scans. (biomedcentral.com)
S. Y. Lin, C. S. Tsai, Y. C. Chang, K. K. Ng, T. C. Chang, W. H. Kao and J. H. Hong* The role of pretreatment FDG-PET in managing cervical cancer patients with enlarged pelvic lymph node(s) shown on MRI: a phase III randomized trial with long-term follow-up. (cgmh.org.tw)
D. L. Tsan, K. H. Fan, Y.C. Chen, C. K. Chuang, C. C. Lee and J.H. Hong* Pre-radiotherapy PSA level as a predictor for biochemical control in prostate cancer patients receiving radiotherapy after radical prostatectomy. (cgmh.org.tw)
P.F. Tsai, S. M. Lin, S. H. Lee, C. Y. Yeh, Y. T. Huang, C. C. Lee, J. H. Hong* The feasibility study of using multiple partial volumetric-modulated arcs therapy in early stage left-sided breast cancer patients. (cgmh.org.tw)
The inflammation based prognostic markers namely platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), serum albumin, CRP, CRP albumin ratio (CAR) have been studied in cervical cancer patients also [4,15-17]. (waocp.com)
Some complex nutrition and inflammation based scores like Cervical Cancer Systemic Inflammation Score, Prognostic Nutritional Index, modified Glasgow Prognostic Score, Systemic Immune Inflammation Index have been evaluated in cervical cancer patients [4,18-20]. (waocp.com)
The randomized clinical trial of 100 patients, with a mean age of 46.6 years and of whom 83% were male, ran from November 2020 to November 2022 at Sun Yat-sen University Cancer Center in China and was sponsored by Sun Yat-sen University, according to the trial's listing on clinicaltrials.gov. (curetoday.com)
In this article, we review the data surrounding the use of chemotherapy (CT) and chemoradiotherapy (CRT) in patients with resectable pancreatic cancer. (cancernetwork.com)
Gulam A. Manji, MD, PhD, of Columbia University Medical Center, discusses phase II results on perioperative combination chemotherapy and pembrolizumab in patients with resectable gastric cancer. (ascopost.com)
Background: This phase 2 prospective randomized double-arm study carried out at Clinical Oncology Department Tanta University, Radiotherapy Department, NCI, Cairo University and Gharbia cancer society through the period from May 2018 to December 2019 and enrolled 60 patients with cervical carcinoma. (oncologyradiotherapy.com)
The response of sixty cervical cancer patients was 70% had no signs of illness after a median of 24 months of follow-up (range 13 months - 36 months),15% still had local residual tumour and 15% had distant metastases. (oncologyradiotherapy.com)
Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. (wjgnet.com)
Laboratory findings in patients with pancreatic cancer are usually nonspecific. (medscape.com)
Patients with advanced pancreatic cancer and weight loss have laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
Nitin Ohri, MD, and his team at the Montefiore Einstein Center for Cancer Care and Albert Einstein College of Medicine conducted a randomized clinical trial to determine if giving cancer patients daily customized step count goals as measured and guided through fitness trackers could improve their ability to tolerate concurrent chemoradiotherapy. (roinstitute.org)
Daily Step Counts Predict Outcomes for Locally Advanced Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy was presented at the 2019 ASTRO Annual Meeting. (roinstitute.org)
This survey, addressed to breast cancer surgeons in Spain, has the objective of assessing current clinical trends on axillary staging of cN + patients treated with NAC. (unav.edu)
Conclusion This survey confirms a trend toward a less invasive approach for axillary staging in cN + patients treated with NAC among breast cancer surgeons in Spain. (unav.edu)
Patients who are radioresistant respond poorly to RT and may experience cancer progression. (nature.com)
Nineteen patients with stage IIB-IIIB non-small cell lung cancer enrolled on the FLARE-RT trial underwent FDG-PET/CT imaging prior to (preRT-PET) and during week 3 (midRT-PET) of concurrent chemoradiotherapy. (aapm.org)

1] Patients generally present with locally advanced or metastatic disease that precludes cure, since symptoms frequently prompt the diagnosis in the absence of effective screening strategies. (cancernetwork.com)
As reported in the Journal of Clinical Oncology by Maron et al, a retrospective study found that use of EGFR inhibitor therapy was associated with benefit in patients with unresectable or metastatic EGFR-amplified gastroesophageal adenocarcinoma. (ascopost.com)
Five-hundred and sixty-six patients with non-metastatic, histologically-confirmed NPC were retrospectively reviewed. (biomedcentral.com)
Fourthly, radiotherapy (RT) is the first choice and main treatment method for non-metastatic NPC. (biomedcentral.com)
In these patients, the conventional long-course concurrent chemoradiotherapy is not suitable because of the risk of progression of the metastatic lesions. (kjco.org)

At the last patient assessment, on July 6, 2023, the median follow-up was 38 months. (medscape.com)
Median follow-up time for all patients was 19 months. (bvsalud.org)
The median follow-up of patients at the time of analysis was 36 months. (iiarjournals.org)
All the patients diagnosed stage III with a median follow-up of 26 months were evaluated. (coek.info)
Median follow-up for all patients was 36 months (range, 1-52 months). (biomedcentral.com)

Fluorouracil has some effect on DNA and is useful in symptom palliation for patients with progressive disease. (medscape.com)
Capecitabine is a prodrug of fluorouracil that undergoes hydrolysis in liver and tissues to form the active moiety (fluorouracil), inhibiting thymidylate synthetase, which in turn blocks methylation of deoxyuridylic acid to thymidylic acid. (medscape.com)

4. Yang J, Shen K, Wang J, Yang J, Cao D. Extrafascial hysterectomy after concurrent chemoradiotherapy in locally advanced cervical adenocarcinoma. (koreamed.org)

Extensive-stage SCLC (ie, SCLC that has spread beyond the supraclavicular areas, or with distant metastases) remains incurable with current management options, and patients are treated with combination chemotherapy. (medscape.com)

None of the patients had paraaortic lymph node (PALN) metastases. (e-roj.org)

Fifty-four patients who were considered to be inoperable underwent CRT. (yyu.edu.tr)

It is commonly used in patients with gastrointestinal malignancies. (medscape.com)

This retrospective review of the literature indicates that numerous drugs have been used for targeted therapy and that the studies of radiotherapy combined with targeted therapy are diverse and complicated by their variable quality. (dovepress.com)
A total of 1,550 serum SCC-Ag tests performed during post-treatment surveillance of the 158 patients were included in this retrospective study. (koreamed.org)

Patients who received preoperative RT in the study had superior local control and reduced toxicity compared with patients in the postoperative group. (biomedcentral.com)
Compared to patients without BOFJ, those with BOFJ had a higher preoperative body mass index (23.3 kg/m 2 versus 20.9 kg/m 2 , P = 0.022), and greater postoperative body weight loss rate: 3 month, decrease to 84.2% of initial body weight versus 89.3% ( P = 0.002). (biomedcentral.com)
Patients of BOFJ had greater preoperative body mass, shorter distance between jejunostomy and midline, and greater postoperative weight loss. (biomedcentral.com)
Therefore, the aim of our study was to clarify the incidence of bowel obstruction associated with a feeding jejunostomy (BOFJ) after thoracoscopic esophagectomy (TSE) and to evaluate the association between BOFJ and the patients' characteristics or postoperative course of change in body weight (BW). (biomedcentral.com)

The significant prognostic factors were stage IV prior to initial therapy (P = .049), development of concurrent local and regional relapse (P = .02), and OPC (P = .04). (elsevierpure.com)
Oropharynx origin, stage IV prior to initial therapy, and concurrent regional relapses were significantly poor prognostic factors. (elsevierpure.com)

Grade 3 neutropenia reported during radiotherapy was significantly difference (p=0.004) as 25% of patients in group A against 0% in group B. (oncologyradiotherapy.com)
Both miRNA-21 and miRNA-18a were highly overexpressed in patients of ESCC and their expressions changed significantly with CRT. (gastrores.org)

Conclusion: Bone marrow sparing improves quality of life and adherence of patients to treatment with reduced adverse events. (oncologyradiotherapy.com)

Many oncologists advocate for adjuvant chemotherapy alone, given that high rates of systemic metastases are the primary cause of patient mortality. (cancernetwork.com)
Patients had to have measurable disease per RECIST v1.1 criteria and have progressed on, or following, 1 to 5 prior systemic treatments. (onclive.com)
Seven patients (five men and two women) underwent short-course RT (5×5 Gy) and preoperative systemic chemotherapy. (kjco.org)

Radiotherapy combined with targeted therapy has considerably furthered the study of non-small-cell lung carcinoma (NSCLC) under the joint efforts of the two disciplines, yielding both exciting results and worrisome reports. (dovepress.com)
Differences in the experimental results prompted this summary for a more comprehensive and rational understanding of radiotherapy combined with targeted therapy. (dovepress.com)
Results: Twenty-four patients (38.7%) were female and 38 (61.3%) were wale. (yyu.edu.tr)
The results to date are promising, and implementing a similar program could be an easy and relatively low cost supportive care measure that almost any clinician could incorporate into his or her practice to help improve outcomes for their patients. (roinstitute.org)

Anatomy9

Diseases84

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment98

Phenomena and Processes11

Disciplines and Occupations5

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science6

Health Care38

Geographicals1

Squamous cell carc11

CCRT20

Chemo-radiotherapy5

Intensity-modulated radiotherapy2

Survival31

Thoracic radiotherapy2

Tumor18

Chemoradiation6

Methods2

Response to neoadjuvant chemoradiotherapy2

Radiation15

Received concurrent cisplatin-based chemotherapy2

Esophageal cancer7

Concomitant5

Neoadjuvant3

Definitive4

Tumors4

Nasopharyngeal carcinoma treated1

Followed by total mesorect1

Modalities2

Pancreatic adenocarcinoma1

Rectal cancer6

Dose10

Surgery26

Head and ne2

Cisplatin1

Locally advanced cervical cancer2

Recurrent9

Recurrence after primary1

Cervix1

20161

IMRT1

Cancer24

Metastatic5

Median5

Fluorouracil2

Adenocarcinoma1

Combination chemotherapy1

Lymph1

Inoperable1

Malignancies1

Retrospective2

Postoperative4

Prognostic factors2

Significantly2

Conclusion1

Systemic3

Results4