Patients undergoing neoadjuvant therapy before surgery. Medical search. Frequent questions

Neoadjuvant therapy may improve chances for complete resection and prevent or delay recurrence after surgery, but the absolute difference in 5-year recurrence-free survival and OS with neoadjuvant chemotherapy alone is only about 6%, they noted. (medscape.com)
more patients receive systemic treatment, fewer patients undergo futile surgery, and R0 resection rates are higher, thereby possibly improving overall survival (OS). (nih.gov)
Although surgical resection remains the cornerstone of treatment, local and distant failure rates are high after complete resection, and debate continues as to the appropriate adjuvant therapy. (cancernetwork.com)
Even among patients who present with localized disease, the 5-year overall survival (OS) is approximately 20%, but potentially higher in patients with complete surgical resection (R0) and uninvolved lymph nodes. (cancernetwork.com)
2,3] Local and/or distant recurrence is common following resection, highlighting the importance of adjuvant therapy. (cancernetwork.com)
All patients underwent curative resection of pancreatic adenocarcinoma without evidence of intraperitoneal disease. (cancernetwork.com)
Currently, neoadjuvant chemo-radiotherapy (nCRT) followed by low anterior resection or abdominoperineal resection are the standard treatments for locally advanced rectal cancer. (sages.org)
Five patients underwent abdominoperineal resection and 76% fell within group A. Six patients had lymph nodes involved. (sages.org)
PRINCIPLES: Trimodal therapy results in long term survival in a small fraction of patients with malignant pleural mesothelioma, particularly in patients having epithelial histology, R0-resection and no nodal involvement. (smw.ch)
CONCLUSIONS: The majority of patients considered for surgical resection of malignant pleural mesothelioma have regionally advanced disease. (smw.ch)
Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients. (smw.ch)
The latter procedure, along with peritoneal lavage is recommended for stage IB-III patients before surgical resection ( 9 ). (frontiersin.org)
Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
To review our outcomes of gluteal VY plasty in the reconstruction of the pelvic floor after extensive abdominoperineal resection (conventional or extralevator abdominoperineal resection, total pelvic exenteration, or salvage surgery). (bvsalud.org)
For instance in RTOG 0229, 66% of patients underwent surgical resection of their tumors. (cornell.edu)
The LEADER trial, together with matched industry-sponsored therapeutic trials, aims to develop data that will support oncologists in their targeted treatment planning for cancer patients prior to the patient undergoing surgical resection. (lungcancerresearchfoundation.org)
However, the prognosis of HCC patients after surgical resection is poor, and the survival rate is not optimistic. (xiahepublishing.com)
Besides, patients are in the terminal stages of HCC when diagnosed, unsuitable for surgical resection, and often have other liver diseases, resulting in a poor prognosis. (xiahepublishing.com)
Furthermore, patients eligible for surgical resection often experience recurrence. (rarediseaseadvisor.com)
however, the effectiveness of this regimen has only been tested in patients who underwent up-front resection. (rarediseaseadvisor.com)
Adjuvant radiation therapy should be used to treat margins that are positive or close to the resection bed. (medscape.com)
27% of patients achieved a complete response, and all of the remaining patients were able to undergo surgical resection. (medscape.com)
Conclusion Failure to complete neoadjuvant therapy and eventual pancreatic resection is associated with BLR stage, increased posttreatment/preoperative CA19-9, and CCI ≥6, but not older age. (johnshopkins.edu)
Older patients who completed neoadjuvant therapy and underwent resection experienced a survival benefit compared with those who did not complete all intended therapy. (johnshopkins.edu)
We hypothesized that adding stereotactic body radiation therapy (SBRT) to anti-PD-1 would be safe prior to definitive surgical resection and would enhance pathological response compared with historical cohorts of patients with locoregionally advanced HNSCC treated with checkpoint inhibitor alone. (bmj.com)
Eligible patients were treated with neoadjuvant SBRT at a total dose of either 40 Gy in 5 fractions or 24 Gy in 3 fractions, delivered in a 1-week timespan, with or without nivolumab, prior to definitive surgical resection. (bmj.com)
A total of 1128 patients who underwent major pulmonary resection for pathologic N1 or N2 NSCLC between 2004 and 2014 were analyzed in this study. (iaslc.org)
Patients treated by elective rectal resection were included. (lu.se)
In this study, we aimed to investigate the prognostic factors of patients with thymoma who received radical resection and establish the nomogram to predict the prognosis of these patients. (biomedcentral.com)
Patients who underwent radical resection for thymoma with complete follow-up data between 2005 and 2021 were enrolled. (biomedcentral.com)
Patients who underwent radical resection for thymoma at our hospital with complete follow-up and histopathological data from 2005 to 2021 were enrolled and analyzed retrospectively. (biomedcentral.com)
The following data were collected from the electronic medical record system: age, gender, presence of autoimmune disease, surgical approach, extent of resection, adjuvant therapy, tumor size, tumor histology according to WHO current classification, and Masaoka-Koga stage. (biomedcentral.com)
A multimodal radiotherapy-containing approach is a well-tolerated component of treatment for patients with osteosarcomas undergoing programed resection, allowing low toxicity rates while maintaining high local control rates. (cun.es)
Patients were carefully selected to participate in the trial if they had undergone a successful surgical resection of their tumor and were in very good health. (pancan.org)
Deep Learning for Fully Automated Prediction of Overall Survival in Patients Undergoing Resection for Pancreatic Cancer: A Retrospective Multicenter Study. (cdc.gov)

Patients receive 8 cycles of neoadjuvant FOLFIRINOX chemotherapy followed by surgery without adjuvant treatment (arm A), or 3 cycles of neoadjuvant gemcitabine with hypofractionated radiotherapy (36 Gy in 15 fractions) during the second cycle, followed by surgery and 4 cycles of adjuvant gemcitabine (arm B). The primary endpoint is OS by intention-to-treat. (nih.gov)
These important studies have illuminated the extent to which postoperative radiotherapy (RT) may provide benefit to patients with adverse pathologic features (extraprostatic extension, seminal vesicle invasion, or positive surgical margins) or biochemical recurrence after radical prostatectomy. (jnccn.org)
2 The argument for postoperative radiotherapy (RT) is predicated on the assumption that some patients may have residual local disease of a potentially lethal phenotype after surgery and that the delivery of secondary local therapy may interrupt the natural history of disease and prevent progression to systemic disease. (jnccn.org)
16 patients (76%) received postoperative adjuvant radiotherapy. (smw.ch)
Methods The Neoadjuvant Immuno-Radiotherapy Trial was an investigator-initiated single institution phase Ib clinical trial that enrolled patients with previously untreated locally advanced HPV-positive and HPV-negative HNSCC between 2018 and 2019. (bmj.com)
Yet, prospective studies that dynamically evaluating the respective roles of radiotherapy, chemotherapy and surgery on anorectal function are lacking. (sagepub.com)
Discussion We expect the program to provide more information of neoadjuvant radiotherapy and/or chemotherapy on anorectal function, and to optimize the treatment strategy to reduce anorectal dysfunction for LARC patients. (sagepub.com)
manometry, Wexner continence score and LARS score However, NCRT, especially neoadjuvant radiotherapy, before and after the treatment and at follow-up visits. (sagepub.com)
Treatment options for thymoma include surgery, radiotherapy, and systemic therapy. (biomedcentral.com)
Radiation therapy, or radiotherapy, uses high-energy rays to damage or kill cancer cells by preventing them from growing and dividing. (kahlertregionalcancer.org)
To assess long-term outcomes and toxicity of adjuvant radiotherapy in the post-surgical management of patients with resected high-grade skeletal osteosarcomas. (cun.es)
Seventy-two patients with primary resected osteosarcomas underwent adjuvant radiotherapy after neoadjuvant chemotherapy from December 1984 to December 2008. (cun.es)
In the past two decades, a multi-therapy approach has increased the rates of clinical response through neoadjuvant chemotherapy, particularly usinga nthracyclines and taxanes-based combination, surgery, radiotherapy and hormone-based therapy 5 . (bvsalud.org)

The neoadjuvant treatment of breast cancer requires a coordinated effort amongst surgical oncology, medical oncology, radiation oncology, nursing, pathology, radiology and clerical booking staff. (bccancer.bc.ca)
The patient should be seen before or at the beginning of NAT by a surgeon to determine the tentative surgical plan and to ensure all essential biopsies and imaging (e.g. axillary), and clip placement have been organized and/or completed. (bccancer.bc.ca)
Patients should be seen by their surgeon halfway through NAT and prior to their last cycle of chemotherapy to determine final surgical plan. (bccancer.bc.ca)
Twelve patients (27%) developed surgical site infection (SSI), eight of which were classified as deep SSI with wound breakdown. (scielo.org.za)
Advances in the surgical management of the axilla in patients treated with neoadjuvant chemotherapy, especially those with node positive disease at diagnosis, have led to changes in practice and more judicious use of axillary lymph node dissection that may minimize morbidity from surgery. (nature.com)
As clinical trials involving neoadjuvant systemic therapy which include pathologic complete response as the primary endpoint increase, standardizing the surgical management in these trials is important in the face of evolving surgical techniques, in particular as it relates to the management of the axilla. (nature.com)
Herein, we present surgical standards for management of the axilla in patients treated with neoadjuvant chemotherapy on clinical trials. (nature.com)
One significant advance in the surgical management of patients treated with neoadjuvant chemotherapy is the potential to allow less invasive surgical intervention in the axilla for those patients who have an excellent response to neoadjuvant chemotherapy. (nature.com)
SECONDARY OBJECTIVES: I. To collect axillary pathology results, surgical staging methods (sentinel lymph node biopsy and/or axillary lymph node dissection ), and management ( surgery and/or radiation) in order to determine axillary nodal response to neoadjuvant chemotherapy and its relationship to breast pCR. (mycancergenome.org)
Besides, 13% of patients were found to be complete pathologic responders upon examination of the surgical specimen. (sages.org)
Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries. (kumc.edu)
In view of the time consuming and intensive treatment it should be offered only in carefully selected patients as new surgical approaches such as pleurectomy/decortication have shown high efficacy rates regarding patients' survival. (smw.ch)
For each eligible patient, clinical history and surgical pathology details were also recorded, including whether the posterior margins were clear, close or positive for tumor involvement, as well as whether tumor invasion of the pectoralis muscle was seen on surgical pathology. (breastcancertalk.net)
Patients with cholangiocarcinoma (CCA) undergoing curative intent surgery appear to have prolonged overall survival and disease-free survival if they receive perioperative chemotherapy, according to a recently published study in the European Journal of Surgical Oncology . (rarediseaseadvisor.com)
They noted that lymph node involvement and positivity of surgical margins could also impact the prognosis of patients receiving preoperative chemotherapy, suggesting that the benefits of perioperative chemotherapy are not observed uniformly, as it benefits particular subgroups of patients. (rarediseaseadvisor.com)
All surgeries were performed using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA). (cancerdiagnosisprognosis.org)
Therefore, an improved predictor is needed to assess whether the patient can tolerate such a complex surgical intervention. (biomedcentral.com)
We hypothesized that if surgical complications following RC are largely due to impaired resilience and recovery, then a lower SMI could potentially serve as an important prognostic indicator for high-risk surgical patients. (biomedcentral.com)
A patient may be diagnosed with stage III cancer following surgical removal of the pancreas and surrounding lymph nodes or after surgical sampling of the lymph nodes. (kahlertregionalcancer.org)
When complete surgical removal of the cancer is possible, stage III pancreatic cancer is best managed by surgery. (kahlertregionalcancer.org)
Despite undergoing surgical removal of all visible cancer, a majority of patients will still experience a recurrence of their cancer because prior to surgery a small amount of cancer spread outside the pancreas and therefore, was not removed by surgery. (kahlertregionalcancer.org)
Much of Wexner's work has been focused on improving surgical techniques for the avoidance of permanent stomas in patients with colorectal cancer, ulcerative colitis, and fecal incontinence. (wikipedia.org)

Two recent randomized trials have suggested benefit of neoadjuvant chemoradiotherapy over upfront surgery, both including single-agent chemotherapy regimens. (nih.gov)
The PREOPANC-2 trial investigates whether neoadjuvant FOLFIRINOX improves OS compared with neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine in resectable and borderline resectable pancreatic cancer patients. (nih.gov)
In this article, we review the data surrounding the use of chemotherapy (CT) and chemoradiotherapy (CRT) in patients with resectable pancreatic cancer. (cancernetwork.com)
Fan, Xin-Juan 2023-05-22 00:00:00 Background Neoadjuvant chemoradiotherapy (NCRT ) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). (sagepub.com)
BMC Cancer (2023) 23:467 Page 2 of 7 Keywords Anorectal function, Locally advanced rectal cancer, Neoadjuvant chemoradiotherapy, Total mesorectal excision, Sphincter preservation treatments Introduction and Wexner continence score or LARS score after differ - Background and rationale ent treatment regimens would be investigated. (sagepub.com)
After providing written informed consent, these adjuvant chemoradiotherapy (NCRT) is being used in patients will undergo sphincter-preserving therapies patients with LARC (T3-T4 or N0-N1), with the pur- including either NCRT with surgery, or NCT with sur- pose of reducing the local recurrence rates and increas- gery or surgery only. (sagepub.com)
Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). (lu.se)
RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. (lu.se)

Combining IO with surgery I think is a new standard of care and will almost certainly improve overall survival [OS] in early-stage disease, for the first time in decades, in my entire career," he said while discussing the new data here at the American Association for Cancer Research (AACR) Annual Meeting 2022. (medscape.com)
Among 358 patients in the trial, the median event-free survival (EFS) was 31.6 months for patients randomly assigned to the combination of the immune checkpoint inhibitor nivolumab and platinum-base chemotherapy, compared with 20.8 months for patients assigned to chemotherapy alone. (medscape.com)
Event-free survival was improved in patients with a pathological complete response compared with those without, suggesting pCR is a surrogate endpoint for long-term outcomes in resectable non-small cell lung cancer, and this is the first time [this has been shown] in a randomized phase 3 study," he said. (medscape.com)
The key landmark study by Wolmark et al in 2001 (NSABP B-18) demonstrated that NAT (with chemotherapy) was safe, with no difference in outcomes of disease free survival (DFS) or overall survival (OS) in patients who received either pre-operative chemotherapy or post-operative chemotherapy 2 . (bccancer.bc.ca)
The NSABP B-6 trial found no significant difference in overall survival (OS) or disease-free survival (DFS) between patients undergoing lumpectomy or a modified radical mastectomy for early breast cancer. (scielo.org.za)
The 5-year overall survival of patients with pancreatic cancer is approximately 5%, with potentially resectable disease representing the curable minority. (cancernetwork.com)
The patients with a complete clinical response expect good survival, but they may still harbor residual disease. (sages.org)
In those receiving trimodal therapy long term survival is achieved only in a minority of patients. (smw.ch)
Objective: The objective of this study was to compare overall survival (OS) and disease free survival (DFS) among patients who underwent minimally invasive esophagectomy (MIE), trans thoracic esophagectomy (TTE) or trans hiatal esophagectomy (THE) for esophageal cancer. (sages.org)
No differences in pCR and survival outcomes were seen between ACEI/ARB users and non-users among breast cancer patients receiving neoadjuvant chemotherapy. (jcancer.org)
The researchers hypothesized that adding bevacizumab (Avastin, Genentech/Roche) to standard chemotherapy (pemetrexed and carboplatin) would increase response rates, improve resectability and potentially prolong survival in this patient cohort. (cornell.edu)
Have short-term oncological outcomes been impacted and how will delays in surgery change long-term reductions in survival? (medjournal360.com)
This number stands to grow following the recent publication of data demonstrating a survival benefit, which will likely prompt more centers to adopt neoadjuvant therapy as a standard of preoperative care (4). (chk1inhibitor.com)
This study aimed to develop a nomogram incorporating non-tumoral liver volume (non-TLV) and liver function markers to predict the patients' overall survival (OS) and disease-free survival (DFS). (xiahepublishing.com)
3 Currently, new antitumor therapies accompanied by various (neo)adjuvant treatments have significantly improved patient survival. (xiahepublishing.com)
Results revealed that median disease-free survival was prolonged in patients receiving perioperative chemotherapy, with a mean disease-free survival of 2.5 years compared to 1.7 years in patients who received surgery alone. (rarediseaseadvisor.com)
Similarly, patients who received perioperative chemotherapy experienced a statistically significant improvement in overall survival compared to patients who received therapy alone. (rarediseaseadvisor.com)
A trend was seen towards better cancer-specific survival in patients with CA-9 positive carcinomas (HR 0.51, p=0.07) on univariate analysis. (ox.ac.uk)
DISCUSSION: MVD was higher in more advanced T- and N-stages and may be used as a determinant of survival in patients with rectal adenocarcinomas. (ox.ac.uk)
A pathological complete response (pCR) is defined as complete disappearance of the tumor before surgery and correlates with 5-year overall survival of the treated patient. (columbia.edu)
Median overall survival for all study patients was 26.1 and 19.7 months (P =.13) for younger and older patients, respectively. (johnshopkins.edu)
Of the 177 patients who completed all therapy, the difference in survival between younger and older patients was not statistically significant (36.5 months vs 27.2 months, P =.47). (johnshopkins.edu)
Clinical trials are ongoing to evaluate neoadjuvant chemotherapy administered alone or in combination with adjuvant therapy, and the results of some small studies suggest that neoadjuvant therapy may improve survival. (kahlertregionalcancer.org)
Similarly, the phase III JAVELIN Ovarian 200 trial of avelumab alone or in combination with pegylated liposomal doxorubicin (PLD) failed to provide a statistically significant improvement in overall survival or progression-free survival versus PLD alone in patients with platinum resistant/refractory ovarian cancer, missing its primary endpoint. (targetedonc.com)
Editor's note: You may have heard breakthrough news that came out of the American Society of Clinical Oncology (ASCO) Annual Meeting yesterday, describing positive results from two phase III clinical trials aimed to improve survival for pancreatic cancer patients who are eligible for surgery. (pancan.org)
Please see the link above to learn more about a study that found that patients treated with chemotherapy and radiation therapy prior to surgery (known as neoadjuvant treatment) had a survival advantage compared to patients who went straight to surgery. (pancan.org)
The median overall survival for patients treated with mFOLFIRINOX was 54.4 months, compared to 38.4 months for patients treated with gemcitabine. (pancan.org)
Surgery offers the best opportunity for long-term survival, and the newly announced results from ASCO can impact clinical practice and further improve outcomes for this patient population. (pancan.org)

He started with a single-arm, single institution phase 2 trial of neoadjuvant axitinib (Inlyta), an oral TKI, in patients with locally advanced, nonmetastatic clear cell RCC. (urologytimes.com)
In the study by Ou and colleagues, the researchers describe the results of a phase 2 trial of neoadjuvant therapy in patients with "unresectable" stage IIIA/IIIB lung adenocarcinoma. (cornell.edu)

2 Therefore, for clinical trials of novel agents in which pCR is the primary endpoint, these definitions-the absence of tumor in the breast as well as in the axillary lymph nodes-are the preferred definitions, reinforcing the importance of accurate assessment of axillary nodes for disease after neoadjuvant chemotherapy. (nature.com)
Tumor tissue collected from biopsy before surgery may help to check if chemotherapy destroyed the breast cancer cells and may be compared to the tumor removed during surgery to check if they are the same. (mycancergenome.org)
PRIMARY OBJECTIVES: I. To assess the accuracy of post-neoadjuvant systemic therapy (NST) image-directed tumor bed biopsy for pathologic complete response (pCR), defined as resolution of both invasive disease and ductal carcinoma in situ ( DCIS ), in cases of clinical and radiologic complete response with trimodality imaging. (mycancergenome.org)
To improve identification and selection of patients with breast and possible axillary pCR for future trial planning, routine biomarkers (estrogen receptor [ER], progesterone receptor [PR], HER2 neu, and Ki67) will be collected to allow comparison to image/clinical complete response (CR), and tumor bed biopsies. (mycancergenome.org)
Our data did not entirely support this policy although it might be the best strategy, based on the predictors of tumor regression, to avoid the complications associated with surgery in elderly patients with significant medical comorbidities and fear of a permanent stoma. (sages.org)
These data helped inform the launch of the phase 2 NAXIVA trial, a single-arm, multi-center trial that included 20 patients with RCC with venous tumor thrombus. (urologytimes.com)
No patients had progression of their primary tumor. (urologytimes.com)
Matching therapies to the oncogenic driver present in a lung tumor has improved outcomes for patients with advanced lung cancer. (lungcancerresearchfoundation.org)
The prognosis of HCC patients is influenced by many factors, the most important of which lie in the tumor itself and the underlying liver condition. (xiahepublishing.com)
9 Imaging findings also showed that poorly differentiated HCC had a shorter tumor volume doubling time, 10 suggesting that the growth rate before surgery can be used to determine the biological characteristics of HCC. (xiahepublishing.com)
Combination radiation therapy with brachytherapy and EBRT is usually employed to deliver a combined dose of 70-80 Gy to the primary tumor volume. (medscape.com)
This will facilitate future virotherapy strategies targeting replicative tumor destruction and stimulation of systemic anti-tumor immunity as possible strategies for neoadjuvant and bladder-sparing therapy. (bcan.org)
Conclusion These data demonstrate that radiation delivered only to the gross tumor volume combined with immunotherapy was safe, resulted in a high rate of mPR and should be further evaluated as a locally focused neoadjuvant therapy for patients with head and neck cancer. (bmj.com)
Many patients only see a doctor when there is some sort of injury to the area or when the tumor weakens a bone so much that it breaks (this is called a pathological fracture). (sarcomahelp.org)
Smoking status and tumor size are risk factors for PFS in patients with thymoma. (biomedcentral.com)
ldquo;But there is synergy between nab-paclitaxel plus anti-PD L1 therapy in mouse tumor models. (targetedonc.com)
Artificial Intelligence-Based Segmentation of Residual Tumor in Histopathology of Pancreatic Cancer after Neoadjuvant Treatment. (cdc.gov)
9. Willingness and ability to provide tissue from one archival tumor tissue sample (either from diagnostic biopsy, primary surgery, or where available from a residual disease post-neoadjuvant therapy). (who.int)

The new results suggest that adding neoadjuvant immunotherapy to chemotherapy will improve upon this, although so far, the OS data from this trial are immature. (medscape.com)

No difference in AT between groups was observed post-neoadjuvant therapy. (nih.gov)

The use of systemic and or radiation therapy prior to surgery (neoadjuvant therapy or NAT) has been studied since the early 1970s. (bccancer.bc.ca)
Patients may also undergo postoperative radiation therapy per standard of care or adjuvant therapy at the investigator's discretion. (mycancergenome.org)
In the CRT arm, there were issues of compliance, with 32% of patients assigned to CRT receiving inappropriate radiation and 25% of patients failing to initiate treatment within 10 weeks post surgery, the protocol-specified time limit. (cancernetwork.com)
Larson, K. (May 2023) Pictorial Review: Breast Conserving Therapy with Intraoperative Radiation Therapy (IORT), Breast Imaging Symposium, National Harbor, Maryland. (kumc.edu)
Adjuvant therapy for mesothelioma often includes radiation and/or chemotherapy. (mesotheliomahub.com)
Preoperative radiation therapy, often included in neoadjuvant protocols, was omitted given the lack of safety data with bevacizumab. (cornell.edu)
Many biologic drugs, including targeted therapies and immune checkpoint inhibitors, have been primarily used in the setting of stage IV disease without radiation therapy. (cornell.edu)
However, Ou and colleagues have shown - albeit in a small trial - that a biologic can be used in place of radiation therapy and that such patients can safely undergo surgery for local control. (cornell.edu)
In some instances, such drugs could prove to be competitive financially to radiation therapy and may actually have less toxicity when combined with chemotherapy. (cornell.edu)
By "saving" it, radiation therapy could then be used in a directed fashion in the adjuvant setting when appropriate for R1 resections or close margins. (cornell.edu)
After establishing the diagnosis and discussing possible treatment options, the patient elected for antiestrogen therapy, palliative tracheostomy, radiation therapy, and hospice services. (breastcancertalk.net)
Most lesions in the middle and distal portions of the vagina are treated with both interstitial and intracavitary radiation therapy. (medscape.com)
Radiation therapy is the standard treatment for patients with stage II vaginal carcinoma. (medscape.com)
Neoadjuvant chemotherapy followed by radical surgery may be an alternative to radiation therapy. (medscape.com)
Osteosarcoma is often treated with a combination of therapies that can include surgery, chemotherapy and radiation therapy. (sarcomahelp.org)
When the cancer cannot be removed by surgery, a combination of anticancer drugs and/or radiation therapy may be given instead. (kahlertregionalcancer.org)
Similar to surgery, radiation therapy is a local treatment used to eliminate or eradicate visible cancers. (kahlertregionalcancer.org)
Radiation therapy is not typically useful in eradicating cancer cells that have already spread to other parts of the body. (kahlertregionalcancer.org)
Clinical studies that have evaluated adjuvant radiation therapy have yielded conflicting results and there currently remains no consensus whether radiation should be used as adjuvant therapy or combined with chemotherapy for the treatment of pancreatic cancer although it is offered to many patients. (kahlertregionalcancer.org)
4 Patients should clearly understand the risks and benefits of being treated with radiation and discuss them with their physician. (kahlertregionalcancer.org)
In an effort to increase the chance that a cancer may be surgically removed, some cancer centers use radiation therapy and chemotherapy before surgery to shrink the cancer. (kahlertregionalcancer.org)
Approximately 25% to 33% of patients are unable to receive chemotherapy or radiation treatment following surgery. (kahlertregionalcancer.org)
In some instances, radiation therapy is also used. (msdmanuals.com)

All of the patients underwent gemcitabine-based neoadjuvant therapy and 71% of the patients eventually underwent surgery. (chk1inhibitor.com)

Potentially, the multi-agent FOLFIRINOX regimen (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) may further improve outcomes in the neoadjuvant setting for localized pancreatic cancer, but randomized studies are needed. (nih.gov)
Oncoplastic breast surgery permits tumours traditionally requiring total mastectomy to be excised with acceptable oncological and aesthetic outcomes. (scielo.org.za)
The purpose of this study was to evaluate outcomes following oncoplastic breast surgery in the breast unit at Inkosi Albert Luthuli Central Hospital in Durban. (scielo.org.za)
Breast-conserving surgery (BCS) using oncoplastic techniques results in favourable oncological outcomes in patients treated in a resource-constrained setting. (scielo.org.za)
This improves subjective patient outcomes regarding body image, psychosocial score and return to work function. (scielo.org.za)
Forty-three patients were enrolled in this clinical trial comparing outcomes of surgery alone to CRT. (cancernetwork.com)
IV pertuzumab in combination with IV trastuzumab and chemotherapy has demonstrated improved outcomes for patients with HER2-positive breast cancer compared with IV trastuzumab and chemotherapy alone. (onclive.com)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study. (smw.ch)
Is neoadjuvant therapy a pathway to improved outcomes in localized kidney cancer? (urologytimes.com)
How can mental health services and primary care best collaborate to enhance physical health outcomes among patients presenting with first episode of psychosis? (hrb.ie)
These findings can contribute to formulating lifestyle advice to improve treatment outcomes and prognosis in patients having CRC in the future. (bvsalud.org)
The aim of this qualitative study was to provide insights into the most important functional outcomes and QoL features experienced by patients during our W&W programme. (bvsalud.org)
Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
We investigated whether the use of ACEI/ARBs affects the clinical outcomes of primary breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy. (jcancer.org)
Imaging features for these 43 eligible patients were recorded according to the Breast Imaging Reporting and Data System lexicon by the single reader blinded to clinical and pathology outcomes. (breastcancertalk.net)
Pancreatic cancer patients who participate in clinical research have better outcomes. (pancan.org)

Although total mesorectal excision is the standard treatment for advanced rectal cancer, recent trends in minimally invasive treatments led to an increase in local excision or "watch and wait" in patients with an excellent response to nCRT. (sages.org)
A total of 29 patients with rectal cancer, who where treated with nCRT from January to August 2017 at "Carlo Urbani" district Hospital in Jesi (Italy), were retrospectively reviewed. (sages.org)
SETTING: An academic hospital and tertiary referral centre for the treatment of locally advanced or locally recurrent rectal cancer, and salvage surgery in The Netherlands. (bvsalud.org)
There is no suitable PROM for rectal cancer patients following a watch-and-wait (W&W) programme. (bvsalud.org)
METHOD: Patients with locally advanced rectal cancer who are enrolled in the W&W programme in the Netherlands were interviewed by telephone using a semistructured interview guide. (bvsalud.org)
Aim To define the distribution, size, location and metastasis of lymph nodes (LNs) within the mesorectum from rectal cancer specimens following total mesorectal excision (TME) surgery without neoadjuvant therapy. (bmj.com)
MATERIALS AND METHODS: Patients (n=101) who underwent surgery for rectal adenocarcinoma without previous neoadjuvant therapy or metastatic disease were selected. (ox.ac.uk)
Effects of neoadjuvant radiochemotherapy for anorectal function in locally advanced rectal cancer. (sagepub.com)
Rectal cancer represents an important public health problem that compromises patients' health-related Methods quality of life. (sagepub.com)
gold standard method in sphincter-preserving therapy The eligible patients will be informed about the study in for locally advanced rectal cancer (LARC) [2, 3]. (sagepub.com)
In 1988 he completed a fellowship in colon and rectal surgery at the University of Minnesota Medical School in Minneapolis, MN. (wikipedia.org)
He also popularized the colonic j-pouch for patients with rectal cancer. (wikipedia.org)
This is now the standard of care for patients with rectal carcinoma across the country and world. (wikipedia.org)

From the viewpoint of drug development, assessment of response to neoadjuvant chemotherapy remains paramount and appropriate assessment of residual disease-the primary endpoint of many drug therapy trials in the neoadjuvant setting-is critical. (nature.com)

Specifically, adaptive trials can efficiently discover new treatments by reducing the number of patients enrolled in treatment groups that show minimal efficacy or higher adverse-event rates. (wikipedia.org)
NEW ORLEANS - For patients with resectable non-small cell lung cancer (NSCLC), further clinical data continue to show benefit from preoperative treatment with the immune checkpoint inhibitor nivolumab (Opdivo) with chemotherapy. (medscape.com)
Treatment protocols for colon cancer are provided below, including adjuvant and neoadjuvant therapy for resectable disease and therapy for advanced or metastatic colon cancer. (medscape.com)
Our study will provide evidence on the neoadjuvant treatment of choice for patients with resectable and borderline resectable pancreatic cancer. (nih.gov)
2 Surgery is an important component in the multimodal treatment of breast cancer. (scielo.org.za)
Definitive Treatment - The term for the best treatment plan for the patient, after considering all options. (newhopemedicalcenter.com)
Dr. Hurvitz indicated that all patients, prior to treatment, will have a clinical prognostic stage calculated, including those undergoing neoadjuvant therapy. (ascopost.com)
If patients have surgery as their initial treatment, they will have pathologic prognostic staging performed. (ascopost.com)
The use of neoadjuvant systemic treatment in the clinical care of patients with breast cancer has increased dramatically over recent years. (nature.com)
For neoadjuvant breast cancer treatment they proposed the rate of pathological complete response (pCR)-the complete eradication of disease-as a surrogate. (nature.com)
However, several newer hormonal therapy drugs, referred to as aromatase inhibitors, have proven to be superior to tamoxifen for the treatment of postmenopausal patients with ER-positive breast cancer and are associated with fewer side effects. (texasoncology.com)
In some cases, participation in a clinical trial utilizing new, innovative therapies may provide the most promising treatment. (texasoncology.com)
The information on this website is intended to help educate patients about their treatment options and to facilitate a mutual or shared decision-making process with their treating cancer physician. (texasoncology.com)
Further therapeutic advances and prospective trials are needed to better define the optimal role of adjuvant and neoadjuvant treatment in patients with resectable pancreatic cancer. (cancernetwork.com)
4,5] Despite the use of neoadjuvant and adjuvant therapies, little progress has been made in the last three decades, and the search for more efficacious treatment continues. (cancernetwork.com)
7] Additionally, the inclusion of both CRT and adjuvant CT after surgery evaluated two treatment variables, making it difficult to discern the true effect of either treatment alone. (cancernetwork.com)
Colorectal liver metastasises were once considered as incurable disease but with better treatment options and valuable input from multi-disciplinary teams, this disease can be cured in a proportion of patients. (wjgnet.com)
AIM: Patient-reported outcome measures (PROMs) are increasingly being used in routine cancer care to evaluate treatment and monitor symptoms, function and other aspects of quality of life (QoL). (bvsalud.org)
An additional - or 'add-on' - therapy given after the original mesothelioma treatment to improve results, prevent recurrence, and relieve pain or other symptoms. (mesotheliomahub.com)
It's designed to make the main treatment more effective and is helpful for patients diagnosed in the early stages of the disease. (mesotheliomahub.com)
It also used as a neoadjuvant treatment - administered before a patient undergoes surgery - in early HER2-positive breast cancer. (pharmaphorum.com)
The use of Perjeta as an adjuvant - a treatment to follow surgery - led to a 27% increase in sales. (pharmaphorum.com)
Hepatectomy is an effective treatment for selected patients with large hepatocellular carcinoma (HCC). (xiahepublishing.com)
Neoadjuvant chemotherapy (NAC) has become a well-established therapy in the treatment of patients with locally advanced or primarily inoperable breast cancer. (columbia.edu)
Subsequent patients will be treated earlier before RC (up to 29 days prior), thereby reducing the interval between TURBT and virus administration to maximize the treatment duration before RC. (bcan.org)
Background Treatment sequencing in older patients is difficult because of concomitant comorbidities and often decreasing performance status. (johnshopkins.edu)
Balancing the toxicity of sequential therapies with their cumulative effect on tolerance and risk for pancreatic surgery will be the key to developing optimal treatment sequencing in older patients with PC. (johnshopkins.edu)
Patients were then planned for treatment with adjuvant nivolumab for 3 months. (bmj.com)
The primary safety endpoint was unplanned delay in surgery considered to be at least possibly related to neoadjuvant treatment. (bmj.com)
The primary efficacy endpoints included pathological complete response (pCR), major pathological response (mPR), and the rate of clinical to pathological downstaging after neoadjuvant treatment. (bmj.com)
Results Twenty-one patients underwent neoadjuvant treatment, which was well tolerated and did not delay surgery, thus meeting the primary endpoint. (bmj.com)
Therefore, a considerable number of patients with suspected #LN5 or #LN6 receive multimodal treatment or, upfront surgery based on imaging staging only. (iaslc.org)
Radical cystectomy (RC) is the standard treatment for patients with muscle-invasive bladder cancer (BC), and it is also a valid option for selected patients with high-risk non-muscle-invasive BC. (biomedcentral.com)
Osteosarcomas range from low grade tumors that only require surgery to high grade tumors that require an aggressive treatment regimen. (sarcomahelp.org)
Pre-treatment neutrophil and lymphocyte counts were obtained from the routine blood test within 1 week before surgery. (biomedcentral.com)
A clinical trial is often recommended following surgery because these standard treatment options are not very effective. (kahlertregionalcancer.org)
It is particularly effective as an adjuvant therapy (therapy given in addition to the primary treatment) to surgery by helping to eliminate any microscopic cancer cells leftover after surgery. (kahlertregionalcancer.org)
Most new treatments are developed in clinical trials, which are studies that evaluate the effectiveness of new treatment strategies in cancer patients. (kahlertregionalcancer.org)
The use of treatment before surgery is referred to as "neoadjuvant therapy. (kahlertregionalcancer.org)
A treatment plan that includes neoadjuvant therapy guarantees that systemic therapy is delivered immediately, which may increase the chance of eradicating small amounts of cancer that may have already spread to distant locations in the body and cannot be removed by surgery. (kahlertregionalcancer.org)
There are 3 principle emerging treatment strategies for ovarian cancer: antiangiogenic therapy, PARP inhibitors, and immunotherapy, said Eskander, assistant clinical professor in the department of reproductive medicine at the University of California, San Diego School of Medicine. (targetedonc.com)
Overall, 23 patients responded to treatment, including 6 (19%) complete responses and 14 PRs. (targetedonc.com)
INTRODUCTION: Treatment of patients with multiple myeloma (MM) in first relapse remains a challenge. (bvsalud.org)
Treatment of acute lymphoblastic leukemia (ALL) requires both systemically and locally directed therapies to prevent central nervous system (CNS) recurrence. (bvsalud.org)
Six patients (8%) developed grade ⩾3 treatment-related chronic toxicity events. (cun.es)
Below, please find answers to frequently asked questions about the trial comparing chemotherapy regimens offered after surgery (known as adjuvant treatment). (pancan.org)
The trial , which took place in France, compared adjuvant treatment options (after surgery ). (pancan.org)
Although a clinical trial had previously shown that FOLFIRINOX is superior to gemcitabine alone in the treatment of patients with metastatic pancreatic cancer, clinicians and researchers did not know if these results would also apply to patients whose tumors are confined to their pancreas and who underwent surgery. (pancan.org)
Therefore, an additional clinical trial was necessary to rigorously compare the new treatment options in this patient population. (pancan.org)
Based on the clinical trial results presented at the ASCO Annual Meeting, health care professionals can immediately start integrating revised neoadjuvant and adjuvant treatment strategies into their practice - while carefully deciding which patients are the best candidates and thoroughly discussing the patient's treatment goals and benefits and risks of various therapeutic options with them. (pancan.org)
A total of 584 patients were included, of whom 347 started treatment. (cancercentrum.se)
The low proportions of patients starting treatment within the target times indicates a great need for improvement. (cancercentrum.se)
Receiving LHRH agonist therapy alongside the same ET treatment for at least 90 days prior to initiation of one of the available study treatments if male or pre-menopausal. (who.int)
Many patients do not access treatment due to financial difficulties. (bvsalud.org)

METHODS: From 2000 to 2005 41 patients with histologically verified malignant pleural mesothelioma were included. (smw.ch)
Methods: A retrospective review of a prospectively maintained database was performed to identify patients who underwent an elective esophagectomy for esophageal cancer at a single institution between 1/1/2003 and 12/31/2008. (sages.org)
Methods Specimens from 60 patients who underwent TME were treated with modified fat clearing solution to retrieve LNs. (bmj.com)
Patients and Methods: Overall, 107 patients with D'Amico high-risk PCa underwent robot-assisted radical prostatectomy with extended pelvic LN dissection without neoadjuvant or adjuvant therapy. (cancerdiagnosisprognosis.org)
In this study, the relationship between lower SMI values and early complications following RC was evaluated by standard reporting methods in a patient cohort. (biomedcentral.com)
METHODS: Enrolled patients received Elo-KRd induction for 4 cycles, and Elo-lenalidomide maintenance until progression. (bvsalud.org)

An institutional lung cancer database of consecutive patients between 2007 and 2016 (N=134) was reviewed retrospectively. (iaslc.org)
We retrospectively analysed 503 consecutive patients with PCa who underwent RARP between September 2014 and October 2020 at our hospital. (cancerdiagnosisprognosis.org)
A total of 247 patients who received RC for BC and 204 age-matched healthy population-based controls were retrospectively assessed. (biomedcentral.com)

Many HER2-positive tumors are downstaged with this current system, because the prognosis of these patients in the HER2-targeted era is better. (ascopost.com)
Understanding the biology of tumors under hypoxic conditions is crucial for the development of anti-angiogenic therapy. (ox.ac.uk)
Most patients with high grade tumors receive about three months of chemotherapy, known as neo-adjuvant therapy, before surgery. (sarcomahelp.org)
By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)

Many oncologists advocate for adjuvant chemotherapy alone, given that high rates of systemic metastases are the primary cause of patient mortality. (cancernetwork.com)
Recent developments in the urologic oncology literature suggest that residual local disease-as opposed to the presence of occult metastases at surgery-may characterize a more substantial component of the natural history of the recurrence and progression of initially clinically localized prostate cancer than previously appreciated. (jnccn.org)
A basic question in this context is the extent to which this sequence of events-versus the presence of occult metastases at surgery-characterizes the natural history of recurrent and progressive disease. (jnccn.org)
200 LN metastases (mLNs) were detected in 33 patients. (bmj.com)

When conducted efficiently, adaptive trials have the potential to find new treatments while minimizing the number of patients exposed to the risks of clinical trials. (wikipedia.org)
The following protocols have been adopted as standard procedure by the I-SPY2 trial for management of axilla in patients with node positive disease, and present a framework for prospective clinical trials and practice. (nature.com)
Looking ahead, Stewart said there are 11 ongoing neoadjuvant RCC clinical trials listed on ClinicalTrials.gov, comprised of 1 phase 1 trial and 10 phase 2 trials. (urologytimes.com)

Adding immunotherapy (IO) to chemotherapy in the neoadjuvant setting represents "a quantum leap in lung cancer therapy," commented David P. Carbone, MD, PhD, director of the James Thoracic Center at the Ohio State University in Columbus. (medscape.com)
However, investigators are exploring a variety of combinations in hopes of augmenting the immune response including chemotherapy plus immunotherapy, immunotherapy plus antiangiogenic therapy, immunotherapy plus PARP inhibitors, and the triplet approach of immunotherapy, PARP, and antiangiogenic agents. (targetedonc.com)

This parallel-arm randomized controlled trial assigned patients with locally advanced esophagogastric cancer to receive prehabilitation or usual care. (nih.gov)
NAT may be considered in certain patients with early stage breast cancer, and is the standard of care for patients with locally advanced breast cancer or inflammatory breast cancer. (bccancer.bc.ca)
1] Patients generally present with locally advanced or metastatic disease that precludes cure, since symptoms frequently prompt the diagnosis in the absence of effective screening strategies. (cancernetwork.com)
However, in patients with locally advanced PCa, pathologically positive LNs have been reported not to be a predictor of biochemical recurrence (BCR) after radical prostatectomy, including robot-assisted radical prostatectomy (RARP). (cancerdiagnosisprognosis.org)

Until the past decade, the use of SEMS was discouraged in preoperative pancreatic cancer patients owing to concerns that these stents might interfere with reconstruction during pancreaticoduodenectomy. (chk1inhibitor.com)
Positive clinical trial results were announced at the ASCO Annual Meeting in 2010, comparing FOLFIRINOX to gemcitabine to treat pancreatic cancer patients with metastatic disease, which is cancer that spread to other organs beyond their pancreas. (pancan.org)
Currently, fewer than 20 percent of pancreatic cancer patients are considered eligible for surgery at diagnosis. (pancan.org)
Evaluation of deep learning based implanted fiducial markers tracking in pancreatic cancer patients. (cdc.gov)
Risk Assessment of Liver Metastasis in Pancreatic Cancer Patients Using Multiple Models Based on Machine Learning: A Large Population-Based Study. (cdc.gov)

This nationwide multicenter phase III randomized controlled trial includes patients with pathologically confirmed resectable and borderline resectable pancreatic cancer with a WHO performance score of 0 or 1. (nih.gov)
The PREOPANC-2 trial directly compares two neoadjuvant regimens for patients with resectable and borderline resectable pancreatic cancer. (nih.gov)

All patients had histologically-confirmed primary adenocarcinoma of the rectum located within 12 cm from the anal verge. (sages.org)
The addition of bevacizumab to induction chemotherapy appeared associated with high objective response and resectability rates among patients with unresectable stage III lung adenocarcinoma, according to findings from a single-center, single-arm, phase 2 study conducted in China. (cornell.edu)

In an interim analysis, the median OS rate was 83% at 2 years for patients treated with nivolumab plus chemotherapy, compared with 71% for patients treated with chemotherapy alone. (medscape.com)

Forty-five patients with 45 tumours were evaluated. (scielo.org.za)
6 A volume replacement procedure is performed in laterally placed tumours where the patient declines contralateral surgery. (scielo.org.za)
The latest, 8th edition of the TNM Classification of Malignant Tumours ( 8 ) is most frequently used to stage patients. (frontiersin.org)
Most cancers were in stage efforts have been made to find factors oesophageal tumours underwent trans- III, followed by stage II. (who.int)

9) report a retrospective cohort of 52 patients who underwent biliary stent placement for relief of malignant obstruction from pancreas cancer. (chk1inhibitor.com)
Adenocarcinomas of the head of the pancreas cause obstructive jaundice (which can cause pruritus) in 80 to 90% of patients. (msdmanuals.com)

Patients were followed until the surgery occurred or the end of the follow-up period (August 21, 2020). (medjournal360.com)
One report suggests that patients with PCa that have few pathologically positive LNs have a lower risk of BCR ( Int J Clin Oncol 25(7) (2020)">7 ). (cancerdiagnosisprognosis.org)
Uneétude descriptive, transversale portant sur les patientes traitées en radiothérapie à l'Hôpital Général de Douala pour cancer du col de l'utérus a été réalisée d'octobre 2020 à janvier 2021.Résultats. (bvsalud.org)
Il s'agissait d'une étude rétrospective descriptive d'une durée de 2 ans 3 mois allant du 1er janvier 2018 au 31 Mars 2020 portant sur 80 dossiers de malades porteurs d'hémopathies malignes et prise en charge dans le centre. (bvsalud.org)
This was a descriptive retrospective study lasting 2 years 3 months from January 1st, 2018 to March 31st, 2020 concerning 80 patients with hematologic neoplasms who were managed in the CNRAO. (bvsalud.org)

The number of events is expected to be reached after inclusion of 368 eligible patients assuming an accrual period of 3 years and 1.5 years follow-up. (nih.gov)
In this international, prospective, cohort study, 20 006 adult patients with cancer who were eligible for curative surgery during the COVID-19 pandemic were included. (medjournal360.com)
Eligible patients had pathologically confirmed non-small cell lung cancer with clinically suspected #LN5 or #LN6 involvement by CT or PET-CT without clinical or pathological evidence of other N2 station involvement. (iaslc.org)
Eligible patients had no prior exposure to a PARP inhibitor or immune-oncology agent. (targetedonc.com)
Efforts are underway, including Early Detection Targeted Grants awarded by PanCAN, to determine the best strategy to detect the disease earlier and allow more patients to be eligible for surgery. (pancan.org)

This is the goal of hormonal therapy for breast cancer. (texasoncology.com)
Tamoxifen is an anti-estrogen drug that has historically been a mainstay of hormonal therapy. (texasoncology.com)
How Does Hormonal Therapy Work? (texasoncology.com)
The goal of hormonal therapy is to decrease the effect of estrogen on cancer cells. (texasoncology.com)
Among these patients, 36 received neoadjuvant hormonal therapy, while two patients received adjuvant ADT after surgery. (cancerdiagnosisprognosis.org)

To correlate imaging results with pathologic nodal status following neoadjuvant chemotherapy for future planning of axillary management in the next study. (mycancergenome.org)
Diagnosis and nodal status were confirmed by surgery. (smw.ch)

We are living in an era of unprecedented advances in cancer treatments with transformative therapies being regularly approved. (pharmaphorum.com)
Therefore, identification of risk factors associated with complications following RC through individual patient counseling, perioperative management planning and evaluation of new treatments is warranted. (biomedcentral.com)
In addition to potentially shrinking the cancer so that it can be removed, neoadjuvant therapy allows patients to avoid the difficulty of undergoing treatments after surgery, which is a time when they may be experiencing side effects. (kahlertregionalcancer.org)
Spark the scientific breakthroughs that innovate treatments to improve the lives of patients. (pancan.org)

Currently, total mesorectal excision (TME) is the multicentre study of patients diagnosed with LARC. (sagepub.com)

For patients undergoing chemotherapy and surgery for esophagogastric cancer, maintenance of fitness is paramount. (nih.gov)

In a presentation made at the 2018 ESMO Congress, that combination induced 5 (15%) PRs among 35 women with BRCA -mutated recurrent ovarian cancer who received at least 3 prior therapy regimens. (targetedonc.com)

21 patients (51%) underwent trimodal therapy with 655 days (63-2,567 days) of median follow-up. (smw.ch)
Overall, 10% of patients (2003) did not undergo surgery after a median follow-up of 23 weeks due to a COVID-19-related reason. (medjournal360.com)

The enrollment criteria, preoperative workup and delivery of neoadjuvant therapy are not what many centers would consider standard. (cornell.edu)

This is a Phase 1 study designed to test the tolerability and feasibility of intravesical therapy with an attenuated Measles virus (MV-NIS) in patients with urothelial carcinoma who are undergoing radical cystectomy but are ineligible or do not desire neoadjuvant chemotherapy. (bcan.org)
The purpose of this study was to evaluate the effect on the lower skeletal muscle index (SMI) of short-term postoperative complications of radical cystectomy (RC) in patients with bladder cancer (BC). (biomedcentral.com)

Staging of axillary lymph nodes has generally been performed by sentinel lymph node (SLN) surgery. (nature.com)
Is image-guided core needle biopsy of borderline axillary lymph nodes in breast cancer patients clinically helpful? (kumc.edu)

13 patients (62%) had postoperative complications. (smw.ch)
On one hand, insufficient lymphadenectomy may result in understaging and undertreatment of a patient, on the other hand, unnecessary lymph node dissection may result in a higher rate of postoperative complications. (frontiersin.org)
Six patients (14.6%) recovered without any postoperative complications during follow-up. (bvsalud.org)

Overall, 35% of patients (n = 7) had a response and 7 (41.2%) of 17 patients who underwent nephrectomy had less invasive surgery than originally planned. (urologytimes.com)
We included 1449 patients with diagnosis of invasive primary breast cancer diagnosed at the MD Anderson Cancer Center between 1995 and 2007 who underwent neoadjuvant chemotherapy. (jcancer.org)

PATIENTS: Forty-one consecutive patients who underwent a pelvic floor reconstruction with gluteal VY plasty at Maastricht University Medical Centre between January 2017 and February 2021 were included. (bvsalud.org)
NEW YORK, Sept. 28, 2021 /PRNewswire/ - The Lung Cancer Mutation Consortium (LCMC) kicks off its fourth study, facilitated by the Lung Cancer Research Foundation (LCRF), examining targeted drugs given as single agents and combinations as neoadjuvant therapies matched to specific genetic mutations. (lungcancerresearchfoundation.org)

For example, the NeoAvAx trial explored the combination of the PD-L1 inhibitor avelumab (Bavencio) and axitinib (Inlyta) in patients with high-risk, non-metastatic clear-cell RCC. (urologytimes.com)

Perjeta (pertuzumab) is a monoclonal antibody used in combination therapy to treat metastatic HER2-positive breast cancer. (pharmaphorum.com)

This study aimed to assess the association of lifestyle with markers of systemic inflammation at the time of diagnosis in stage I-III colorectal cancer patients. (bvsalud.org)
Patients (n = 298) with stage I-III colorectal cancer from three Dutch hospitals were included at diagnosis. (bvsalud.org)
Surgery occurring 12 weeks after diagnosis increased during lockdown in patients who were not undergoing neoadjuvant therapy. (medjournal360.com)
An x-ray is often the first diagnostic test that osteosarcoma patients receive, and an experienced radiologist may recognize immediately that bone cancer is the likely diagnosis. (sarcomahelp.org)

Most of these patients required hospitalization and suffered a delay in their neoadjuvant regimen (5). (chk1inhibitor.com)
First, I seek to identify breast cancer patients who will not respond to NAC shortly after the initiation of a 5-9 months therapy regimen. (columbia.edu)
Identifying these patients early will allow a switch to a more promising therapy and avoiding months of ineffective therapy with a drug regimen that has considerable side effects. (columbia.edu)
This work analyzed DOT data from 105 patients with stage II-III breast cancer under NAC regimen. (columbia.edu)
FOLFIRINOX is known to be a particularly powerful chemotherapy regimen and can cause severe side effects in patients. (pancan.org)

Results from this trial were the basis of the US Food and Drug Administration's recent approval of neoadjuvant therapy with nivolumab (Opdivo) and platinum-based chemotherapy in this population, which one expert described as a "a turning point in how we treat resectable NSCLC. (medscape.com)
however, he said that in 2 trials of neoadjuvant nivolumab (Opdivo), "none of the patients had a partial response. (urologytimes.com)

About one fourth of all patients who are diagnosed with NSCLC have resectable disease, Girad and colleagues noted. (medscape.com)
However, from 30% to 55% of patients who undergo surgery with curative intent ultimately experience recurrence and die from their disease. (medscape.com)
however, adjuvant therapy may be considered in patients with high-risk disease. (medscape.com)
Male patients, those with contraindications to breast conservation, and those with metastatic disease were excluded. (scielo.org.za)
DR. HURVITZ noted that under the 8th AJCC system, most triple-negative breast cancer is upstaged and more hormone receptor-positive disease is downstaged (especially if patients are HER2-positive). (ascopost.com)
In HER2-negative, hormone receptor-positive disease, many are downstaged as well, and now we're able to use genomic profiling to further downstage some patients who have a low Recurrence Score," she added. (ascopost.com)
The involved patients completed nCRT and had no recurrence disease, distant metastasis, synchronous malignancies. (sages.org)
An emerging body of literature showing efficacy for secondary RT suggests that residual local disease after surgery may represent a much more important avenue of prostate cancer progression than previously appreciated. (jnccn.org)
DFS was defined as the interval between surgery and recurrence in the form of local recurrence or metastatic disease. (sages.org)
Almost half (46%) of patients had a partial response (RECIST) and 13 patients had stable disease. (urologytimes.com)
Among patients with a partial response, 10 (83%) of 12 were disease-free at the study data cutoff. (urologytimes.com)
We analysed whether this is true for patients with chronic kidney disease (CKD). (micrornamimic.com)
We hypothesized that in CKD patients of young age and predominant sole renal disease, aortic stiffness has no predictive value for proteinuria. (micrornamimic.com)
Patients with bulky N2 disease, those with T4N2 disease and those with N3 disease were all included. (cornell.edu)
These patients undoubtedly had very advanced disease, some potentially having metastatic disease at presentation. (cornell.edu)
The most interesting argument to be made is for more trials evaluating novel therapeutics with neoadjuvant chemotherapy for patients with lung cancer and stage III disease. (cornell.edu)
Understanding how this approach can be extended to patients with early-stage lung cancer has the potential to further transform how we treat this disease and have a positive impact on patients," said Katerina Politi, PhD, Associate Professor of Pathology and Internal Medicine at Yale School of Medicine and chair of LCRF's Scientific Advisory Board. (lungcancerresearchfoundation.org)
The effectiveness of combined neoadjuvant therapy and adjuvant therapy (perioperative chemotherapy) in patients with borderline resectable disease has not yet been analyzed. (rarediseaseadvisor.com)
Adequately treated Stage I or II cancer from which the patient is currently incomplete remission or other cancer from which the patient has been disease-free for 2 years. (bcan.org)
Most patients are diagnosed with high grade disease that does not appear to have spread throughout the body. (sarcomahelp.org)
However, it is believed that about 80% of patients with high grade osteosarcoma already have metastatic disease that is not yet visible on imaging tests. (sarcomahelp.org)
Among 36 patients with platinum-resistant disease, 6 patients had partial response (PR) and 12 had stable disease. (targetedonc.com)
Thirteen patients had stable disease lasting at least 4 months. (targetedonc.com)

Patients with PCa and pathologically positive lymph nodes (LNs) are considered to have a worse prognosis than those with negative LNs ( J Urol 178(3 Pt 1) (2007)">4 - Eur Urol 55(6) (2009)">6 ). (cancerdiagnosisprognosis.org)

Anatomy1

Diseases22

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes2

Disciplines and Occupations4

Information Science1

Health Care15

Resection36

Radiotherapy13

Surgical22

Chemoradiotherapy8

Survival28

Phase 2 trial of neoadjuvant2

Tumor18

Suggest that adding neoa1

Post-neoadjuvant therapy1

Radiation23

Gemcitabine-based1

Outcomes16

Rectal13

Response to neoadjuvant1

Treatment54

Methods6

Retrospectively3

Tumors4

Metastases4

Clinical trials3

Immunotherapy2

Locally advanced4

Pancreatic cancer patients5

Resectable pancreatic cancer2

Adenocarcinoma2

Treated with chemotherapy1

Tumours4

Pancreas2

20205

Eligible5

Hormonal therapy5

Nodal status2

Treatments4

Total mesorect1

Chemotherapy and surgery1

Regimens1

Median2

Centers1

Radical cystectomy2

Axillary lymph2

Postoperative complications3

Invasive2

20212

Inhibitor1

Metastatic HER2-positive breast cancer1

Diagnosis4

Regimen5

Opdivo2

Disease23

Lymph nodes1