Patients undergoing high dose chemotherapy and hematopoietic stem cell transplantation treatment of severe peripheral bone marrow transplantation. Medical search. Frequent questions

Oral and gastrointestinal (GI) mucositis affects almost all patients undergoing high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT), 80% of patients with malignancies of the head and neck receiving radiotherapy, and a wide range of patients receiving chemotherapy. (wikipedia.org)
The purpose of this study is to evaluate the effectiveness of vedolizumab when added to background aGvHD prophylaxis regimen compared to placebo and background aGvHD prophylaxis regimen on intestinal aGvHD-free survival by Day +180 in participants who receive allo-HSCT as treatment for a hematologic malignancy or myeloproliferative disorder. (mayo.edu)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
Patient will undergo autologous HSCT next month. (pocketdentistry.com)
Explained to patient the oral complications of HSCT, chemotherapy, and radiation. (pocketdentistry.com)
Donor lymphocyte infusion (DLI) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been widely used in preventing post-transplant relapse. (bvsalud.org)
Donor-specific anti-HLA antibodies (DSA) are a major cause of engraftment failure in patients receiving haploidentical haematopoietic stem cell transplantation (Haplo-HSCT). (bvsalud.org)
however, treatment outcomes in long-term survivors who survive for at least 2 years post-HSCT without relapse are yet to be elucidated. (bvsalud.org)
To explore the life expectancy trends and late complications and to assess the main mortality-related factors, we investigated the characteristics of patients who received allo-HSCT for haematological malignancies from 2007 to 2019 in our centre and survived in remission for 2 years. (bvsalud.org)
Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)
Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. (bvsalud.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Cardiac complications have been described in HSCT with the majority of reported cardiac complications during HSCT attributed to the use of high-dose cyclophosphamide [30]. (slideshare.net)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) after CAR T-cell therapy has emerged as a promising strategy to prolong LFS. (biomedcentral.com)
Nevertheless, which patients are likely to benefit from consolidative allo-HSCT, as well as the optimal therapeutic window, remain to be explored. (biomedcentral.com)
In patients having these risk factors, consolidative allo-HSCT after CAR T-cell therapy may prolong LFS. (biomedcentral.com)
Allo-HSCT provides optimal clinical benefit in patients with MRD-negative complete remission, typically within three months after CAR T-cell therapy. (biomedcentral.com)
Herein, we summarize the clinical data on consolidative allo-HSCT after anti-CD19 CAR T-cell therapy, as well as the potential factors associated with allo-HSCT benefit. (biomedcentral.com)
For decades, allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been regarded as the only well-established curative cellular therapy for patients with B-ALL. (biomedcentral.com)
Furthermore, r/r B-ALL patients may develop severe organ damage or infection after aggressive chemotherapy and, hence, be precluded from allo-HSCT. (biomedcentral.com)
The combination of CAR T-cell therapy and allo-HSCT has been suggested to reduce the relapse rate of leukemia. (biomedcentral.com)
Nonetheless, consolidative allo-HSCT is not recommended for all patients because it will increase the economic burden and bring risk of severe toxicity, such as graft-versus-host disease (GVHD). (biomedcentral.com)
BK virus reactivation has been described as significant and often severe complications occur, especially in patients with hematopoietic stem cell transplantation (HSCT). (uic.edu)
16 According to the 2009 American Society for Blood and Marrow Transplantation (ASBMT) guidelines for preventing infectious complications among hematopoietic cell transplant recipients, evidence is lacking for support of universal prophylactic treatment of BK virus with quinolones or cidofovir, as well as routine testing of HSCT recipients or donors for BK virus antibodies. (uic.edu)

The mutation occurs in hematopoetic stem cells capable of self renewal and additional mutations are associated with clonal progression may occur in progenitor cells conferring a self renewal capability. (standardofcare.com)
The paradox is that the mutation provides advantage at the stem cell level and progenitor cells, with a disadvantage at the level of hematopoietic precursors. (standardofcare.com)
Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
The mobilisation and apheresis procedures should be performed in collaboration with an oncology-haematology centre with acceptable experience in this field and where the monitoring of haematopoietic progenitor cells can be correctly performed. (medicines.org.uk)
B lood cell differentiation begins with multipotent hematopoietic progenitor cells (HPCs), which are located in the marrow spaces of the bone. (nationalacademies.org)
As the cells reproduce, they commit to a particular task or cell line and become known as committed progenitor cells . (nationalacademies.org)
These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Transplanted tissue may be cells (e.g., hematopoietic stem cells Hematopoietic stem cells Progenitor cells from which all blood cells derived. (lecturio.com)

Patients with malignancies and those undergoing chemotherapy are often immunocompromised and are at high risk of acquiring bacterial and viral infections that can cause hemorrhagic cystitis. (medscape.com)
Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E: Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. (karger.com)
a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al. (nationalacademies.org)
It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. (the-medical-dictionary.com)
Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. (lookformedical.com)
Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)

Appropriate management of therapy and complications is only possible when adequate diagnostic and treatment facilities are readily available. (nih.gov)
Patients with myelodysplastic syndromes (MDS) collectively have a high symptom burden and are also at risk of death from complications of cytopenias and acute myeloid leukemia. (standardofcare.com)
Are other atypical white blood cells an asset to address complications? (cryostem.org)
The donor's cells are not as well matched to the patient's cells as in a standard allogeneic transplant, which increases the risk of complications such as graft-versus-host disease (GVHD) and graft rejection. (vanyahealth.com)
To reduce the risk of these complications, special techniques are used to purify the donor's stem cells before transplantation. (vanyahealth.com)
See "HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets)" and "Evaluation and treatment of hypertensive emergencies in adults" and "Catastrophic antiphospholipid syndrome (CAPS)" and "Early complications of hematopoietic cell transplantation", section on 'Thrombotic microangiopathy' . (medilib.ir)

However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
In such cases, the transplantation procedure is prioritized during the early stages, provided a suitable donor is identified. (medistateinternational.com)
The decision to proceed with stem cell transplantation for these conditions hinges on a comprehensive evaluation of the disease's course, severity, donor-related attributes, and procedural risks. (medistateinternational.com)
The success of stem cell transplantation pivots on the identification of a donor possessing either a fully-matched or partially-matched tissue group with the patient. (medistateinternational.com)
The primary purpose of this study is to estimate and compare overall survival between the two arms: patients who are Very Likely to find a Matched Unrelated Donor (MUD) versus those who are Very Unlikely to find a MUD. (mayo.edu)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
In this type of transplant, stem cells are taken from a donor (usually a close relative or sibling) and given to the patient. (vanyahealth.com)
Cord blood transplants are an alternative to using stem cells from a matched adult donor. (vanyahealth.com)
Both haploidentical BMT and cord blood transplant are considered alternative options for patients who do not have a suitable matched donor. (vanyahealth.com)
10% of patients undergo transplant due to advanced age, comorbid conditions, or lack of a suitable donor. (dermatologyadvisor.com)

Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
Similarly, the outcomes of myeloablative conditioning and reduced-intensity conditioning regimens for allo-HCT and their relationship with pretransplant consolidation cycles for patients in first complete remission are also unknown. (ascopost.com)
A total of 1,473 patients with a median age of 47 years received myeloablative conditioning, and 1,162 patients with a median age of 63 years received reduced-intensity conditioning. (ascopost.com)
About 328 patients received myeloablative conditioning, and 150 patients, reduced-intensity conditioning. (ascopost.com)
01). Treatment-related mortality was similar for patients with primary induction failure vs those in first complete remission after myeloablative or reduced-intensity conditioning allo-HCT (Table 1). (ascopost.com)
This large retrospective analysis on behalf of the CIBMTR shows again that among patients eligible for allo-HCT, only one induction cycle to achieve first complete remis sion, particularly when combined with one consolidation therapy, is associated with better outcomes after myeloablative conditioning and not reduced-intensity conditioning. (ascopost.com)

We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
Because a major loss or dysfunction of T cells can cause secondary B-cell deficiency, numerous disorders have clinical manifestations of combined B-cell and T-cell deficiency, although the only pathology is in the T cell. (medscape.com)
In other B-cell and T-cell disorders, additional anomalies may predominate, and clinical manifestations suggestive of immunodeficiency may occur late in life. (medscape.com)
Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
In randomised clinical trials, a subcutaneous dose of 230 µg/m 2 /day (4.0 to 8.4 µg/kg/day) was used. (medicines.org.uk)
clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)
Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
These data suggest that with appropriate pre-transplant clinical evaluation, high-dose cyclophosphamide and irradiation in the BMT preparative phase does not result in frequent, clinically relevant short-term cardiac toxicity [31]. (slideshare.net)
Recent clinical data indicate that patients with complex karyotypes, adverse genes, and high pre-infusion minimal residual disease (MRD) by flow cytometry in the bone marrow, were at high risk of relapse after CAR T-cell therapy. (biomedcentral.com)
Patients should be managed according to their individual clinical and biological characteristics and by patient and physician preferences. (researcher.life)
Duration of treatment should be based on the patient's clinical response. (wikidoc.org)
treatment should continue for at least 7 days after both neutropenia and clinical symptoms are resolved. (wikidoc.org)
If the 50-mg dose is well tolerated but does not provide an adequate clinical response, the daily dose can be increased to 70 mg. (wikidoc.org)
Duration of treatment should be dictated by the patient's clinical and microbiological response. (wikidoc.org)
Duration of treatment should be based upon the severity of the patient's underlying disease, recovery from immunosuppression, and clinical response. (wikidoc.org)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
BL-8040 is currently undergoing a Phase 2a clinical trial for the treatment of relapsed or refractory AML. (technologynetworks.com)
Unfortunately, the term is often used to describe any patient with a TMA who does not have severe ADAMTS13 deficiency or a documented Shiga toxin, therefore it has little clinical usefulness. (medilib.ir)
Characteristics of patients in clinical trials may differ from those of real-world patients. (qxmd.com)
The clinical, imaging, and prognosis data for 86 TNBC patients were retrospectively reviewed. (qxmd.com)
1 To date, there are no published guidelines available in the United States to guide clinical decision making for optimal management of patients presenting with this syndrome. (uic.edu)

While alternative therapeutic techniques persist, bone marrow/peripheral stem cell transplantation emerges as a transformative option, particularly when other methods display limited efficacy. (medistateinternational.com)
Antibody- and T-cell-based approaches to targeting of B-cell maturation antigen have shown efficacy. (merckmanuals.com)
The safety and efficacy of Neupogen are similar in adults and children receiving cytotoxic chemotherapy. (medicines.org.uk)
Although anti-CD19 chimeric antigen receptor (CAR) T-cell therapy shows good efficacy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL), it fails to improve long-term leukemia-free survival (LFS). (biomedcentral.com)
Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (worldsbest.rehab)
The efficacy of caspofungin at this higher dose was not significantly better than the efficacy of the 50-mg daily dose of caspofungin. (wikidoc.org)
The efficacy of doses higher than 50 mg daily in the other adult patients for whom caspofungin is indicated is not known. (wikidoc.org)
Accordingly, pre-conditioning of MSCs is strongly suggested to upgrade their performances in vivo, leading to more favored transplantation efficacy in regenerative medicine. (biomedcentral.com)
The efficacy of adjuvant chemotherapy combined with immunotherapy in patients with resected cholangiocarcinoma needs to be substantiated. (qxmd.com)

Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)
Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
There is clonal proliferation of malignant hematopoietic stem cells, dysregulated cellular differentiation, and compromised tissue function. (standardofcare.com)
Epstein-Barr virus (EBV) infection has been prominently associated with HPS, with clonal proliferation and the hyperactivation of EBV-infected T cells. (biomedcentral.com)
Hemophagocytic syndrome (HPS) is a potentially fatal condition due to dysregulated lymphocyte activation and proliferation, mainly characterised by impaired or inactive natural killer (NK) cells and cytotoxic T cells, which leads to macrophage hyperactivation and over-expression of cytokines [ 1 ]. (biomedcentral.com)
SOX9 promotes nasopharyngeal carcinoma cell proliferation, migration and invasion through BMP2 and mTOR signaling. (cancerindex.org)
Overexpression of SOX9 promoted NPC cell proliferation, migration and invasion. (cancerindex.org)
They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation. (lookformedical.com)

The myelodysplastic syndromes are a group of clonal bone marrow neoplasms characterised by ineffective haematopoiesis and manifested by dysplasia of haematopoietic cells and by peripheral cytopenia(s).2 They have a variable predilection for the development of acute myeloid leukaemia (AML). (researcher.life)
The myelodysplastic syndromes (MDS) include a heterogeneous group of clonal bone marrow failure syndromes characterized by cytopenias, clonally restricted hematopoiesis (associated with an abnormal G-banded metaphase karyotype in about 50% of cases), genomic instability, and a risk of progression to acute myeloid leukemia (AML). (dermatologyadvisor.com)

All patients in DSA group achieved haematopoietic reconstitution and the median neutrophils and platelets engraftment times were 13 (10-21) and 13 (10-29) days respectively. (bvsalud.org)

These 3 syndromes are associated with decrease circulating levels of T cells (but circulating levels of B cells are normal) and often decreased levels of IgA, IgE, and IgG subclasses. (medscape.com)
This document represents an update of the British Society of Haematology Guideline published in 2014 due to advances in understanding the biology and therapy of the myelodysplastic syndromes (MDS).1 The objective of these guidelines is to provide healthcare professionals with clear guidance on the management of adult patients with MDS. (researcher.life)
INTRODUCTION - The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on distinguishing these primary syndromes from other systemic disorders that can present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. (medilib.ir)
These syndromes require urgent, targeted treatment directed at the TMA pathophysiology. (medilib.ir)

Clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis and peripheral cytopenias. (standardofcare.com)
Criteria for diagnosis of MDS consist of anemia, thrombocytopenia, or neutropenia that persist for six months or longer, dysplasia greater than 10% in at least one bone marrow cell lineage, and MDS associated clonal cytogenetic abnormalities or molecular markers. (standardofcare.com)
The clonal outgrowth of mutant stem cells favors and abnormal hematopoietic stem cell niche. (standardofcare.com)

Since the first successful organ transplant in 1954, advancements in medical technology, immunology, and pharmacology have increased the success rate of solid organ transplantation. (pocketdentistry.com)

The most severe manifestations occur within the first 2 years of life as various types of severe combined immunodeficiency (SCID). (medscape.com)
At these high doses, serious cardiotoxicity may occur [32]. (slideshare.net)
It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
Splenomegaly is present in approximately 50% of patients at presentation, and hepatosplenomegaly may occur. (medscape.com)

Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

I am scheduled to undergo stem cell transplantation and chemotherapy in the next month due to recurrence of lymphoma in the lymph nodes surrounding my spleen. (pocketdentistry.com)
Lymphoma was treated bi‐weekly with ABVD combination chemotherapy (A = Doxorubicin Hydrochloride (Adriamycin), B = Bleomycin, V=Vinblastine Sulfate, D = Dacarbazine). (pocketdentistry.com)
3 , 4 Since 2020, older or unfit patients are treated by a non-intensive approach combining the hypomethylating agent azacitidine and the B-cell lymphoma 2 (BCL2) inhibitor venetoclax given orally until progression. (dovepress.com)
This procedure is typically used to treat blood cancers such as leukemia, lymphoma, and multiple myeloma, as well as other disorders such as sickle cell anemia and thalassemia. (vanyahealth.com)
Obinutuzumab and reduced bendamustine is effective for elderly patients with follicular lymphoma. (u-tokyo-hemat.com)
Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Because the chromosomal t(14;18) translocation is found in the majority of patients with follicular lymphoma, bone marrow aspiration and chromosome analysis can also help establish the diagnosis. (medscape.com)
Most patients with follicular lymphoma present at an advanced stage, and most patients have bone marrow involvement at diagnosis. (medscape.com)
Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)
Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)

There are two main types of Bone Marrow Transplantation (BMT): autologous and allogeneic. (vanyahealth.com)

Pediatric dose is calculated based on the child's body surface area. (rxlist.com)
In a pharmacokinetic study of BUSULFEX in 24 pediatric patients, the population pharmacokinetic (PPK) estimates of BUSULFEX for clearance (CL) and volume of distribution (V) were determined. (nih.gov)
For pediatric patients aged 12 to 14 years weighing greater than or equal to 50 kg and those aged 15 years and older regardless of body weight use adult dosage. (nih.gov)
9) and in pediatric patients with any degree of hepatic impairment. (wikidoc.org)
Alibegashvili T, Clifford GM, Vaccarel a S et col . in pediatric high-grade gliomas. (who.int)

The only curative therapy is hematopoietic stem cell transplantation. (frontiersin.org)
Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (worldsbest.rehab)
Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (worldsbest.rehab)

To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)

Patients who undergo hematopoietic stem cell transplantation frequently have hemorrhagic cystitis because most are exposed to cyclophosphamide, total-body irradiation, or both. (medscape.com)

In this month's Pharmacy SIG Literature Update: Impact of anti-T-lymphocyte globulin dosing on GVHD in MUD SCT, impact of MRD status before alloHCT on outcomes in secondary AML, low-dose post- transplant cyclophosphamide with low-dose antithymocyte globulin for prevention of GVHD in MUD SCT and more. (astct.org)
An important and unanswered question concerns the impact of the number of conventional AML chemotherapy induction cycles to achieve first complete remission on transplant outcomes. (ascopost.com)
Compared with the poor outcomes of patients who received allo-HCT during refractory (active) disease, the outcomes of patients who received more than one induction cycle to achieve complete remission is somewhat better but remains unsatisfactory. (ascopost.com)
Our objective was to describe biomarker testing and outcomes among patients with advanced non-small cell lung cancer (aNSCLC) in a real-world setting. (qxmd.com)

Data from the United Network of Organ Sharing ( UNOS ) and the Organ Procurement and Transplantation Network ( OPTN ) catalog over 175,000 transplants between the years 2000 and 2015 (Optn.transplant.hrsa.gov 2016 ). (pocketdentistry.com)
High-dose chemoradiotherapy is the major cause of organ toxicity. (slideshare.net)
Transplantation is a procedure that involves the removal of an organ or living tissue and placing it into a different part of the body or into a different person. (lecturio.com)
Organ transplantations have become the therapeutic option of choice for many individuals with end-stage organ failure. (lecturio.com)
Over the past half-century, organ transplantation has become a successful and evolving practice which provides benefit to over 100,000 individuals yearly worldwide. (lecturio.com)
Tolerance Tolerance Pharmacokinetics and Pharmacodynamics of the transplanted organ by the immune system Immune system The body's defense mechanism against foreign organisms or substances and deviant native cells. (lecturio.com)
Observation is recommended for patients with advanced disease until they develop systemic symptoms or disease that threatens organ function. (medscape.com)

Noninfectious hemorrhagic cystitis most commonly occurs in patients who have undergone pelvic radiation (see the image below), chemotherapy, or both. (medscape.com)
There is a need for further investigation into the effects of and guidelines for exercise interventions (especially strength training) in this population of patients, particularly among cancer patients who are undergoing or have undergone chemotherapy or radiation treatments. (karger.com)
In this type of transplant, the patient's own stem cells are collected before the high-dose chemotherapy and/or radiation therapy is given. (vanyahealth.com)
After the chemotherapy and radiation therapy, the stored stem cells are thawed and returned to the patient's body. (vanyahealth.com)
This type of transplant is used when the patient's own cells are not damaged or diseased, but are being used as a rescue therapy after high-dose chemotherapy or radiation therapy. (vanyahealth.com)
More than 85% of MDS cases are idiopathic or "de novo", while 10-15% are secondary to a recognized prior exposure to a DNA damaging agent such as alkylating agent / topoisomerase inhibitor chemotherapy, or ionizing radiation. (dermatologyadvisor.com)
Hemorrhagic cystitis (HC) may be a complication of infection (particularly in immunocompromised patients), chemotherapy, or radiation to the pelvic area. (uic.edu)

The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
The bone marrow microenvironment and inflammatory signaling can also determine the rate of development and progression of MDS. (standardofcare.com)
Early loss or exhaustion of CAR T cells, selection of CD19-negative clones, downregulation of CD19 expression, lineage switch of leukemia, and tumor microenvironment are important factors contributing to relapse after CAR T-cell therapy [ 9 , 10 ]. (biomedcentral.com)
Cancer is a complex and dynamic disease, initiated by a multitude of intrinsic mutations and progressed with the assistance of the tissue microenvironment, encompassed by stromal cells including immune cell infiltration. (qxmd.com)
The spatial distribution and interactions of cells in the tumor immune microenvironment (TIME) might be related to the different responses of triple-negative breast cancer (TNBC) to immunomodulators. (qxmd.com)

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Most patients with myelodysplastic syndrome have greater than one mutation and a unique pattern of mutation with marked heterogeneity. (standardofcare.com)
Somatic mutation is not a static process in myelodysplastic syndrome and additional mutations will accumulate leading to more profound phenotypic worsening cytopenias, and approximately 30% of patients will eventually experience progression to secondary AML. (standardofcare.com)
Are you sure your patient has a myelodysplastic syndrome? (dermatologyadvisor.com)

The patient population consisted of 77 adults with DHL/THL who received APBHSCT between January 2012 and December 2020 following a BEAM (carmustine, etoposide, cytarabine, melphalan) conditioning regimen. (astct.org)
This retrospective cohort study included patients ≥18 years old, diagnosed with stage IIIB/C or IV NSCLC, and in the TEMPUS oncology dataset from January 1, 2012, to December 31, 2020. (qxmd.com)
Data from 101 patients with cholangiocarcinoma treated at the Sun Yat-sen University Cancer Center between 2015 and 2020 were studied. (qxmd.com)

Conditions associated with bone marrow failure such as aplastic anemia with hypocellular marrow, typical bone marrow findings of MDS are a hypercellular marrow for a persons age, dysplasia in 1 to 3 lineages manifested by pseudo Pelger-Huet nuclei, hypogranular neutrophils, micro megakaryocytes, and/or ringed sideroblasts, glass Siri glass, and increased myeloblasts in a subset of patients. (standardofcare.com)
The bone marrow in MDS is usually hypercellular for age, but about 10% of cases are accompanied by a hypocellular marrow, and such cases may be difficult to distinguish from aplastic anemia. (dermatologyadvisor.com)

Severe infections are emerging as major risk factors for death among children with juvenile idiopathic arthritis (JIA). (cdc.gov)
In particular, children with refractory JIA treated with long-term, multiple, and often combined immunosuppressive and antiinflammatory agents, including the new biological disease-modifying antirheumatic drugs (DMARDs), are at increased risk for severe infections and death. (cdc.gov)
Reporting all cases of severe infections and especially deaths in these children is of paramount importance for accurate surveillance. (cdc.gov)
Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (SCID). (frontiersin.org)
The patient presented at 14 months of age following recurrent infections, from early infancy, with persistent irritability, developmental delay, and hypotonia. (frontiersin.org)
Male patients with thrombocytopenia and eczema may have Wiskott-Aldrich syndrome with defective T-cell function and resultant recurrent infections. (medscape.com)
In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
Neupogen is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 × 10 9 /l) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate. (medicines.org.uk)
Patients who have had a bone marrow transplant are at an increased risk of infections due to the suppression of their immune system. (vanyahealth.com)
Caspofungin is an antifungal that is FDA approved for the treatment of fungal infections , candidemia , esophageal candidiasis , invasive aspergillosis refractory or intolerant to other therapies. (wikidoc.org)
Treatment of candidemia and the following Candida infections: intra-abdominal abscesses, peritonitis and pleural space infections. (wikidoc.org)
median: 14 days) have been studied in 100 adult patients with candidemia and other Candida infections. (wikidoc.org)
Because of the risk of relapse of oropharyngeal candidiasis in patients with HIV infections, suppressive oral therapy could be considered. (wikidoc.org)
In patients who were treated empirically or who had candidemia or other Candida infections (intra-abdominal abscesses, peritonitis, or pleural space infections), a similar modest effect of age was seen in older patients relative to younger patients. (theodora.com)

Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)
In patients with unexplained anemia, thrombocytopenia, or neutropenia without dysplasia in the bone marrow but with abnormal chromosome activity in 5, 7 or 13 the diagnosis is consistent with MDS and occurs in less than 10% of patients with MDS. (standardofcare.com)
MDS with lower risk transformation to AML are typically characterized by low myeloblast percentages, fewer genetic variants, or by genetic variants associated with a better prognosis, less severe anemia, thrombocytopenia, or neutropenia. (standardofcare.com)
MDS with higher risk of transformation to AML are typically characterized by a higher percentage of myeloblasts, more genetic variants or genetic variants associated with the worse prognosis with a greater degree of anemia, neutropenia, or thrombocytopenia. (standardofcare.com)
It's also rare to have isolated thrombocytopenia without anemia in MDS, so other causes (such as immune thrombocytopenia or a drug effect) should be ruled out if a patient presents with isolated thrombocytopenia and no anemia or neutropenia. (dermatologyadvisor.com)
Symptoms related to bone marrow dysfunction, such as anemia, leukopenia, or thrombocytopenia, are rare at presentation but can also be observed in the later stages of the disease. (medscape.com)
INITIAL EVALUATION (ALL PATIENTS) - Individuals with a TMA may come to medical attention with any of a variety of presentations including unexplained anemia or thrombocytopenia, unexplained neurologic findings (suspected stroke or transient ischemic attack), or other acute illness. (medilib.ir)

Among patients undergoing head and neck radiotherapy, pain and decreased oral function may persist long after the conclusion of therapy. (wikipedia.org)
citation needed] As a result of cell death in reaction to chemo- or radio-therapy, the mucosal lining of the mouth becomes thin, may slough off and then become red, inflamed and ulcerated. (wikipedia.org)
The decision to proceed with transplantation hinges on a thorough assessment of patients' chances for successful results, along with a comprehensive understanding of therapy-related risks. (medistateinternational.com)
The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
Neupogen therapy should only be given in collaboration with an oncology centre which has experience in G-CSF treatment and haematology and has the necessary diagnostic facilities. (medicines.org.uk)
In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of Neupogen therapy. (medicines.org.uk)
Discovery and availability of biomarkers suitable for screening high risk patients using early, non-invasive, blood tests specific for GvHD-therapy resistance would significantly aid in the management of patients with this disease and would allow for rational drug development and drug approval by regulatory authorities. (cryostem.org)
Using proteomics, it has been shown that plasma concentration of Suppression of Tumorigenicity 2 (ST2), accurately stratified patients according to risk of non-response to acute GvHD therapy in large retrospective sets. (cryostem.org)
0.5 x 109 cells/kg and being transplanted in CR1 versus CR/PR from second-line therapy were identified as independent predictors for OS and PFS. (astct.org)
In a combined analysis of categorical groups, the patients in the high A- ALC group transplanted in CR1 had the best prognosis for OS and PFS and patients in the low A- ALC group transplanted in CR/PR after second-line therapy had the worse prognosis for OS and PFS. (astct.org)
When data are from a reference laboratory that is likely to receive referral isolates from patients who are intolerant of therapy or for whom therapy has failed, there is a potential for bias in their interpretation. (antimicrobe.org)
Consolidative allogeneic hematopoietic stem cell transplantation after chimeric antigen receptor T-cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia: who? (biomedcentral.com)
High pre-lymphodepletion lactate dehydrogenase, low pre-lymphodepletion platelet count, absence of fludarabine in lymphodepletion, persistent leukemic sequence by high throughput sequencing in bone marrow after CAR T-cell infusion, and early loss of CAR T cells have also been linked to relapse after CAR T-cell therapy. (biomedcentral.com)
Finally, and most importantly, we provide recommendations for the assessment and management of r/r B-ALL patients undergoing anti-CD19 CAR T-cell therapy. (biomedcentral.com)
Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (worldsbest.rehab)
Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
Patients who remain persistently neutropenic may warrant a longer course of therapy pending resolution of the neutropenia. (wikidoc.org)
In addition to typical cardiovascular treatment for patients with angina pectoris or myocardial infarction, we perform specialized surgeries and other forms of medical services, such as ablation therapy, using advanced devices (e.g., catheters, pacemakers, and implantable cardioverter-defibrillators) for patients with various types of arrhythmia, as well as proper postoperative management. (keio.ac.jp)
We also diagnose and treat adrenal hypertension and adrenal incidentaloma, perform insulin therapy for diabetic patients, and provide general care for patients with metabolic disorders. (keio.ac.jp)
The trial aims to improve the response of AML patients to the second stage of AML treatment, termed consolidation therapy, by eliminating the minimal residual disease left in the bone marrow after the first stage of the standard treatment regimen, called induction therapy. (technologynetworks.com)
CARTITUDE-4 ( NCT04181827 ) is the first international, randomized, open-label Phase 3 study investigating the treatment of adult patients with relapsed and lenalidomide-refractory multiple myeloma who have received cilta-cel vs standard-of-care regimens, including pomalidomide, bortezomib and dexamethasone (PVd) or daratumumab, pomalidomide and dexamethasone (DPd), following one to three prior lines of therapy. (wedbush.com)
It is the longest follow-up for any BCMA-targeted CAR-T cell therapy study to be presented at the meetings. (wedbush.com)
Mesenchymal stem/stromal cells (MSCs)‐based therapy brings the reassuring capability to regenerative medicine through their self‐renewal and multilineage potency. (biomedcentral.com)
Although there is no particular quantitative assay to provide MSCs identification in mixed cells population [ 8 ], the International Society for Cellular Therapy (ISCT) has provided minimum principles to determine MSCs. (biomedcentral.com)
Stem cell therapy has been the subject of many studies for its potential to cure many disorders. (biomedcentral.com)

The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
US 2012/0058091 discloses diagnostic and therapeutic treatments related to mitochondrial disorders. (justia.com)
Collectively, these results identify a novel role for SOX9 as a potential therapeutic marker for the prevention and treatment of NPC. (cancerindex.org)
Hence, the development of new therapeutic strategies that overcome these obstacles and achieve durable remission in r/r B-ALL patients are urgently warranted. (biomedcentral.com)

Daratumumab plus lenalidomide and dexamethasone for relapsed POEMS syndrome with bone plasmacytoma harboring 17p deletion. (u-tokyo-hemat.com)

Under this program, eligible patients will incur no out of pocket costs for their first Nplate or Neulasta treatment associated with a new treatment regimen and will pay a maximum of $25 for subsequent injections. (amgen.com)
The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx ) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (worldsbest.rehab)

What biomarkers for diagnosis and monitoring of treatment of GvHD? (cryostem.org)
The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)

Stem cell transplantation is considered when these approaches prove ineffective, emphasizing the importance of exhausting all available options. (medistateinternational.com)
Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at excessive doses, the toxicity (side-effects) will be intolerable to the person receiving it. (worldsbest.rehab)

From various cancer types like leukemia to congenital or acquired hematologic conditions leading to bone marrow insufficiency and immune system deficiencies, this method addresses diverse health concerns. (medistateinternational.com)
The immune system's lymphocyte component is divided into B cells and T cells. (medscape.com)
Symptoms in affected patients indicate the crucial involvement of MHC proteins in the immune recognition of self and nonself. (medscape.com)
Genetic HPS is heterogeneous and arises from defects in the critical regulatory pathways responsible for the natural termination of immune responses that lead to the failure of the homeostatic removal of cells that are superfluous or dangerous to the host. (biomedcentral.com)
The main advantage is that cord blood cells are less mature than adult stem cells, which makes it less likely for the patient's immune system to reject the transplant. (vanyahealth.com)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components. (lecturio.com)
Microangiopathic hemolytic anemia (MAHA) - MAHA is a descriptive term for non-immune hemolysis (ie, Coombs-negative hemolysis) resulting from intravascular red blood cell fragmentation that produces schistocytes on the peripheral blood smear ( picture 1 ) [ 1 ]. (medilib.ir)
The novel finding that tumors can evade anti-cancer immune functions shaped the field of immunotherapy, which has been a revolutionary approach for the treatment of cancers. (qxmd.com)
However, the development of predominantly T cell-targeted immunotherapy approaches, such as immune checkpoint inhibition, also brought about an accumulation of evidence demonstrating other immune cell drivers of tumor progression, such as innate immune cells and notably, neutrophils. (qxmd.com)

The complete results from a 5-year open-label extension study of Nplate in the adult chronic ITP setting show that Nplate increases and sustains platelet counts in these patients and that adverse event rates were consistent with those reported in previous studies," said Sean Harper, M.D., senior vice president, Global Development and Chief Medical Officer at Amgen. (amgen.com)
The usual adult dose of Cancidas is one 70 mg loading dose, followed by 50 mg once daily, continuing for at least 14 days after symptom resolution. (rxlist.com)
Adult patients with mild hepatic impairment (Child-Pugh score 5 to 6) do not need a dosage adjustment. (wikidoc.org)
For adult patients with moderate hepatic impairment (Child-Pugh score 7 to 9), caspofungin 35 mg once daily is recommended based upon pharmacokinetic data. (wikidoc.org)
Adult patients on rifampin should receive 70 mg of caspofungin once daily. (wikidoc.org)
Adult patients on nevirapine , efavirenz , carbamazepine , dexamethasone , or phenytoin may require an increase in dose to 70 mg of caspofungin once daily. (wikidoc.org)

The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
All patients with a diagnosis of MDS must be discussed at a multidisciplinary team meeting (MDT), which should include allogeneic stem cell transplant representation. (researcher.life)

It permits the administration of exceedingly high doses of chemotherapy, a practice that becomes viable due to the subsequent infusion of the patient's own stem cells. (medistateinternational.com)
An A-ALC cell infusion containing 0.5 x 109 cells/kg was chosen as a cutoff to evaluate for prognosis. (astct.org)

Seventy-five to eighty percent of bone marrow transplantation recipients experience mucositis, of which oral mucositis is the most common and most debilitating, especially when melphalan is used. (wikipedia.org)

Although the cumulative incidence of II-IV aGVHD (41.4% vs. 28.1%) and 3-year moderate to severe cGVHD (16.8% vs. 7.2%) were higher in DSA cohort than in the control, no statistical significance was observed. (bvsalud.org)
This trial confirmed the results of other trials that demonstrated a substantial incidence of symptomatic hypotension in MM patients in the peri-transplant period following ASCT. (astct.org)
Golestan Province, Iran, a high incidence area. (who.int)

The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
She experienced nausea and vomiting during treatment phase and was confined for long periods of time to her house or the hospital because of her immunocompromised state. (pocketdentistry.com)

Lesions are caused by bone replacement by expanding plasmacytomas or by cytokines that are secreted by malignant plasma cells that activate osteoclasts and suppress osteoblasts, leading to bone loss. (merckmanuals.com)

High-dose melphalan followed by autologous peripheral blood stem cell transplantation may also be used. (merckmanuals.com)
Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
Later, they were administered high-dose etoposide, 1,500 mg/[m.sup.2], followed by granulocyte colony-stimulating factor for collection of peripheral blood stem cells. (the-medical-dictionary.com)

This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)

and were called hematopoiesis-supporting cells in BM [ 3 ]. (biomedcentral.com)

Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)

When the bone marrow hematopoietic cells are mostly clonally derived cells, the disease is clinically manifested as cytopenia and morphologic dysplasia. (standardofcare.com)

Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
Impact of autograft-absolute lymphocyte count on survival in double/triple hit lymphomas post-autologous stem cell transplantation. (astct.org)
Despite the fact that most follicular lymphomas are advanced at the time of diagnosis, many patients may not require treatment for prolonged periods of time, and the median survival of patients with follicular lymphomas has historically been approximately 8-10 years. (medscape.com)

Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
Risk factors for the development of orthostatic hypotension during autologous stem cell transplant in patients with multiple myeloma. (astct.org)
Toxic shock like syndrome caused by Streptococcus agalactiae bacteremia during treatment for multiple myeloma. (u-tokyo-hemat.com)
This was the study that showed - in front of the international community back in 2017 -promising results in heavily pretreated patients with multiple myeloma. (wedbush.com)
CARTITUDE-1 is a Phase 1b/2 study evaluating cilta-cel for the treatment of heavily pretreated patients with relapsed or refractory multiple myeloma. (wedbush.com)
This first-in-human, Phase 1 study evaluates LCAR-B38M CAR-T cells in patients with relapsed and refractory multiple myeloma. (wedbush.com)

most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
A common reference range for the absolute neutrophil count (ANC), which is calculated on the basis of the percentage of neutrophils in the white blood cell count (see the Absolute Neutrophil Count calculator) is 2500-8000/µL. (medscape.com)
Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)

Two died while receiving high-dose systemic corticosteroids, methotrexate, and after recent exposure to anti-tumor necrosis factor-α biological DMARDs, and 2 during hematopoietic stem cell transplantation procedure. (cdc.gov)
In the case of low-risk HPS, corticosteroids and/or intravenous immunoglobulin or cyclosporine A may be sufficient to control the biological process, but etoposide is recommended as a means of reversing infection-dependent lymphohistiocytic dysregulation in high-risk cases. (biomedcentral.com)
Carefully monitor patients receiving Voriconazole for injection and corticosteroids (via all routes of administration) for adrenal dysfunction both during and after Voriconazole for injection treatment. (nih.gov)

For certain types of leukemia, conventional chemotherapy methods present a viable treatment avenue. (medistateinternational.com)
Often, conventional medical treatment options are limited, leaving stem cell transplantation as a potential game-changer. (medistateinternational.com)
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)

The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
The pathognomonic characteristic of HPS is the activation of well-differentiated macrophages, phagocyting erythrocytes, leukocytes and platelets in bone marrow, lymph nodes, spleen, liver and other organs, which can infiltrate almost anybody district and may account for many of its systemic features [ 3 ]. (biomedcentral.com)
It can affect the skin, liver, and gut and can be severe or life-threatening in some cases. (vanyahealth.com)

PNP is expressed at high levels in lymphocytes and causes the release of ribose phosphate by converting inosine to hypoxanthine, guanosine to guanine, and deoxyguanosine to guanine. (frontiersin.org)
Traditionally, B cells have been believed to be the lymphocytes responsible for antibody production via maturation into plasma cells (ie, humoral immunity), and T cells have been believed to be the lymphocytes responsible for killing other cells or organisms (ie, cellular immunity). (medscape.com)
Currently, certain T lymphocytes (ie, T-helper cells) are known to be responsible for helping immature B cells develop into mature B cells. (medscape.com)
Other T lymphocytes (ie, T-suppressor/cytotoxic cells) possess the killing function and also inhibit B-cell development. (medscape.com)
1] Deoxyguanosine and deoxyadenosine are more toxic in lymphocytes than in other cell types. (medscape.com)
Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS. (lookformedical.com)

The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)
Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
Since 1999, various genetic loci related to the activity of perforin and granzyme granules have been associated with genetic autosomal recessive HPS, thus explaining the impaired or absent function of NK cells and cytotoxic T cells [ 2 , 6 ]. (biomedcentral.com)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. (lookformedical.com)

Ulcers may act as a site for local infection and a portal of entry for oral flora that, in some instances, may cause septicaemia (especially in immunosuppressed patients). (wikipedia.org)
We report a patient with PNP deficiency, who received HLA-identical sibling marrow without chemotherapy because of disseminated cytomegalovirus (CMV) infection. (frontiersin.org)
In view of the disseminated CMV infection, the decision was made to infuse stem cells without any pre-conditioning chemotherapy. (frontiersin.org)
Mucosal candidias is well documented, and patients can also present with disseminated BCG infection if they have been vaccinated. (frontiersin.org)
NBS is characterized by microcephaly with growth retardation, normal or impaired intelligence, birdlike facies, increased susceptibility to infection, humoral and cellular immunodeficiency, and high risk for lymphatic tumor development. (medscape.com)
Patients are generally advised to call their doctor in case of fever, symptoms of infection or painful injection sites, as these may progress severely without adequate medical attention. (the-medical-dictionary.com)
The Department of Pulmonary Medicine provides high-quality medical care for patients with lung diseases or respiratory symptoms, such as COPD (chronic obstructive pulmonary disease), bronchial asthma, respiratory infection, interstitial pneumonia, lung cancer, and sleep apnea syndrome. (keio.ac.jp)

The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease. (lookformedical.com)

The MDS cell of origin is a hematopoetic stem cell that proliferates and escapes apoptosis. (standardofcare.com)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
Positive data from the dose-escalation stage of the study, which was recently presented at the 2014 ASH (American Society of Hematology) Conference, has shown substantial mobilization of AML cancer cells from the bone marrow to the peripheral blood and robust apoptosis of these cells, as well as an excellent safety and tolerability profile. (technologynetworks.com)

Anatomy33

Organisms13

Diseases57

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Psychiatry and Psychology2

Phenomena and Processes37

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science4

Named Groups6

Health Care18

Geographicals1

HSCT35

Progenitor cells11

Malignancies6

Complications6

Donor13

Myeloablative7

Clinical21

Efficacy9

Proliferation8

Group of clonal bone2

Reconstitution1

Syndromes4

Clonal3

Solid organ transplantation1

Occur4

Transplant Recipients1

Lymphoma11

Autologous and allogeneic1

Pediatric5

Curative3

Hematologic neoplasms1

Total-body irradi1

Outcomes4

Organ7

Radiation7

Microenvironment5

Myelodysplastic4

20203

Hypocellular marrow2

Infections14

Thrombocytopenia7

Therapy26

Therapeutic4

Lenalidomide1

Regimen3

GVHD2

Ineffective2

Immune10

Adult6

Allogeneic stem cell trans2

Infusion2

Recipients1

Incidence3

Hospital2

Malignant1

Blood stem3

Immunosuppression1

Hematopoiesis1

Stromal1

Cytopenia1

Lymphomas3

Multiple Myeloma6

Neutrophils3

Corticosteroids3

Conventional3

Liver3

Lymphocytes6

Cytotoxic5

Infection7

Tumors1

Apoptosis3