• Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
  • Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT). (kcl.ac.uk)
  • The aim of this study was to analyse the impact of pre-IFD on overall survival (OS) and IFD free survival in patients with myeloid malignancies and aplastic anaemia who underwent allo-HSCT.Methods: A large single centre retrospective analysis was performed on patients with myeloid malignancies and Aplastic anaemia (n=369) who consecutively underwent allo-HSCT between Jan 2012 and June 2016. (kcl.ac.uk)
  • Patients with pre-IFD (n=76) i.e. with history of actively treated IFD within 3 months of HSCT, were compared with those without pre-IFD (n=293). (kcl.ac.uk)
  • Approximately 60-70% of patients undergoing HSCT will reactivate CMV and without prompt antiviral therapy 20-30% will go on to develop CMV end organ disease. (ucl.ac.uk)
  • Peptide mixes were utilised that cover the CMV antigens pp65 and IE1 to study the functionality of CD4+ and CD8+ T cells in patients post HSCT. (ucl.ac.uk)
  • The data presented here demonstrates the importance of a CD4+ T cell response to CMV in the HSCT setting and also highlights the benefit of both a CD8+ T cell responses to both IE1 and pp65. (ucl.ac.uk)
  • Myeloablative allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure usually accompanied by multifactorial malnutrition, prompting the recommendation of systematic artificial nutritional support. (biomedcentral.com)
  • Recently published data suggest that enteral nutrition (EN), given as systematic artificial nutrition support, could decrease grade III-IV graft-versus-host disease (GVHD) and infectious events, which are associated with early toxicity after allo-HSCT and then have an impact on early transplant-related mortality (D100 mortality). (biomedcentral.com)
  • We report on the NEPHA trial: an open-label, prospective, randomised, multi-centre study on two parallel groups, which has been designed to evaluate the effect of EN compared to PN on early toxicity after an allo-HSCT procedure. (biomedcentral.com)
  • Two hundred forty patients treated with allo-HSCT for a haematological malignancy will be randomly assigned to two groups to receive either EN or PN. (biomedcentral.com)
  • Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a major procedure, and is usually conducted to consolidate remission of haematological malignancies. (biomedcentral.com)
  • Allo-HSCT includes administration of a chemotherapy-based conditioning regimen (myelo-ablative or non-myelo-ablative), followed by infusion of alloreactive haematopoietic stem cells, with the aim of inducing an active immunological anti-tumoral effect. (biomedcentral.com)
  • For practical and historical reasons, parenteral nutrition (PN) is often the first option chosen for patients undergoing an allo-HSCT [ 13 ]. (biomedcentral.com)
  • Indeed, allo-HSCT patients all have a central-venous access that facilitates PN administration. (biomedcentral.com)
  • Relapse remains the leading cause of death in acute myeloid leukemia (AML) patients following allogeneic hematopoietic stem - cell transplantation (allo-HSCT), limiting the efficacy of allo-HSCT. (bvsalud.org)
  • We retrospectively enrolled 414 younger patients ( aged 14-60 years) with AML who received allo-HSCT between January 2014 and May 2020. (bvsalud.org)
  • A single-center cohort representing 664 admissions for induction or hematopoietic stem cell transplant (HSCT) from 2006-2014 was selected. (wustl.edu)
  • 1 Intestinal aGvHD is a serious complication characterized by inflammation of the GI tract which can affect patients undergoing allo-HSCT, a common treatment for blood cancers. (businesswire.com)
  • Lower GI aGvHD represents a critical unmet need in patients undergoing allo-HSCT," said Yi-Bin Chen, MD, Director, Hematopoietic Cell Transplant & Cell Therapy Program, Mass General Cancer Center. (businesswire.com)
  • The Phase 3, randomized, double-blind, placebo-controlled, multicenter GRAPHITE study evaluated the efficacy and safety of vedolizumab as prophylaxis for intestinal aGvHD in patients undergoing allo-HSCT from unrelated donors for the treatment of hematological malignancies. (businesswire.com)
  • Effective prevention of aGvHD, especially with lower intestinal involvement, has been an important treatment goal for physicians when patients are undergoing allo-HSCT. (businesswire.com)
  • 1 The study enrolled 333 patients who were randomly assigned in a 1:1 ratio to one of two treatment groups receiving either an intravenous infusion of vedolizumab 300 mg or placebo on days -1 (before allo-HSCT), and on days +13, +41, +69, +97, +125, and +153 following allo-HSCT, alongside a background GvHD prophylaxis regimen. (businesswire.com)
  • Allogeneic hematopoietic stem cell transplantation (HSCT) in thalassemia remains a challenge. (nih.gov)
  • In adult patients, the 23-years OS and TFS after HSCT were 70 ± 5% and 67.3 ± 5%, compared to 71.2 ± 5% of OS in CT (P = NS). (nih.gov)
  • In conclusion, the 30-year survival rate of ex-thalassemia patients after HSCT was similar to that expected in CT thalassemia patients, with the vast majority of HSCT survivors cured from thalassemia. (nih.gov)
  • There is a paucity of data examining the tolerance and outcome of hematopoietic stem cell transplantation (HSCT) for relapse after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • There is a paucity of data examining the tolerance andoutcome of hematopoietic stem cell transplantation (HSCT) for relapse aftertositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • Five patients received autologous HSCT: threemarrow and two peripheral blood stem cells. (cancernetwork.com)
  • CONCLUSION: These data demonstrate the feasibility of allogeneic orautologous HSCT in heavily pretreated lymphoma patients who also receivedtositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • In patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT), however, EFS and OS were not significantly different between FHL2 or iASPP high- and low-expression groups. (nature.com)
  • Fortunately, monotherapy with amphotericin B was effective, and the patient underwent allo-HSCT. (frontiersin.org)
  • Mucormycosis is a rare but life-threatening opportunistic fungal infection associated with immunocompromised patients with hematologic malignancies, persistent neutropenia, poorly controlled diabetes mellitus, iron overload, and trauma, undergoing solid organ or hematopoietic stem cell transplantation (HSCT), or receiving corticosteroid therapy ( 1 ). (frontiersin.org)
  • Hematopoietic stem cell transplantation (HSCT) is increasingly used effectively to treat various hematological diseases. (bvsalud.org)
  • The "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project, was founded at the Dental School of Universidade Federal de Minas Gerais (UFMG) in March 2001 and is responsible for providing dental care to patients who have undergone and will undergo HSCT, in addition to those from the UFMG Clinical Hospitalwho are only undergoing hematological treatment. (bvsalud.org)
  • This study aimed to present the various activities of the "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project, which provides dental care to eligible patients during pre- and post-HSCT. (bvsalud.org)
  • Thus, the "Dental services for HSCT patients from the UFMG Clinical Hospital" extension project plays an important role in teaching, research, and extension activities within the UFMG Dental School, especially concerning HSCT. (bvsalud.org)
  • We sought to confirm the prognostic importance of simple clinically available biomarkers of C-reactive protein, serum albumin, and ferritin prior to allogeneic hematopoietic cell transplantation. (haematologica.org)
  • NEW YORK, Aug. 15, 2023 (GLOBE NEWSWIRE) - IN8bio, Inc. (Nasdaq: INAB), a leading clinical-stage biopharmaceutical company focused on innovative gamma-delta T cell therapies, today announced William Ho, CEO and co-founder, will participate in a fireside chat at the H.C. Wainwright Immune Cell Engager Virtual Conference on Thursday, August 17, 2023 at 2:00 pm ET. (itbusinessnet.com)
  • In 2023, the Lund Stem Cell Center turns 20 years old. (lu.se)
  • STUDY DESIGN AND METHODS: To identify factors independently influencing platelet transfusion efficacy after hematopoietic progenitor cell transplantation, a prospective study was performed to determine the effectiveness of platelet transfusions by estimating posttransfusion (16-hour) corrected count increments (CCI) in 42 consecutive patients (26 who received allogeneic transplants and 16 who received autologous transplants) with 439 available platelet transfusions. (elsevierpure.com)
  • Could enteral nutrition improve the outcome of patients with haematological malignancies undergoing allogeneic haematopoietic stem cell transplantation? (biomedcentral.com)
  • Allogeneic hematopoietic stem cell transplantation (AHSCT) is an established therapy in the treatment of hematological malignancies. (isth.org)
  • It is also expected to provide critical information to further develop this immune cell-based therapy for treatment of multiple other malignancies. (lls.org)
  • Prophylactic donor lymphocyte infusions after haploidentical haematopoietic stem cell transplantation for high risk haematological malignancies: a retrospective bicentric analysis of serial infusions of increasing doses of CD3 cells. (stembook.org)
  • Secondary endpoints will compare EN and PN with regards to the main haematological, infectious and nutritional outcomes. (biomedcentral.com)
  • Thus, the ability to identify high- risk patients in a manner that permits early intervention has the potential to improve survival outcomes. (bvsalud.org)
  • The MRD status at the time of allo-SCT was an important prognostic factor for CIR and EFS in both patient cohorts, with MRD positivity linked to adverse outcomes. (oncpracticemanagement.com)
  • However, MRD-positive patients transplanted in CR1/CR1i had comparable CIR and EFS outcomes as MRD-negative patients transplanted in CR2/CR2i, thus highlighting the worse outcomes of transplantation in CR2/CR2i. (oncpracticemanagement.com)
  • In the European LeukemiaNet intermediate-risk patient cohort, both MRD-negative patients transplanted in first or second CR/CRi had favorable outcomes in terms of CIR and EFS, while MRD-positive patients transplanted in CR1/CR1i showed modest outcomes, and MRD-positive patients transplanted in CR2/CR2i experienced poor outcomes. (oncpracticemanagement.com)
  • infection and for the emergence of oseltamivir-resistant The following patient information was collected by use of virus to inform modifi cations to current recommendations a standardized questionnaire: demographic details, clinical for the use of antiviral drugs for treatment and prophylaxis symptoms, complications, outcomes (hospitalization, of infl uenza A pandemic (H1N1) 2009 virus infection. (cdc.gov)
  • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • Associate Professor Carr hopes to not only elucidate the underlying mechanisms of action of vitamin C, but to also improve the outcomes of patients with these conditions. (otago.ac.nz)
  • The Patient-Reported Outcomes Measurement Information System (PROMIS)-57 and the PROMIS Cognitive Function Short Form were used as research tools. (bmj.com)
  • Successful outcomes following allogeneic hematopoietic cell transplant (HCT) may be offset by risks of transplant-related morbidity and mortality. (haematologica.org)
  • Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
  • In the current study, the authors investigated whether patients expressed regret after undergoing HCT and the relationships between clinical outcomes and quality of life. (cdc.gov)
  • Implementing rapid, culture free diagnostic PCR methods improves patient outcomes. (bruker.com)
  • Impact of second-degree related donor on the outcomes of T cell-replete haploidentical transplantation with post-transplant cyclophosphamide. (stembook.org)
  • Impact of donor age and kinship on clinical outcomes after T-cell-replete haploidentical transplantation with PT-Cy. (stembook.org)
  • Associations with outcomes were analyzed for the 32 mutations found in ≥ 20 patients. (ascopost.com)
  • In this population-cohort study, Arshad and coworkers analyzed deceased-donor kidney transplant outcomes stratified by donor-to-recipient size ratios in 11720 adult patients that were transplanted in the UK between 2013 and 2015. (tts.org)
  • Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
  • In pediatric patients, one fourth of fungal endocarditis cases have systemic candidal infection with cardiac involvement. (medscape.com)
  • A novel risk model for predicting early relapse in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem-cell transplantation. (bvsalud.org)
  • This retrospective analysis was conducted in a large academic medical center in Germany to gain insights into the prognostic value of measurable residual disease (MRD) in patients with acute myeloid leukemia (AML) who underwent allogeneic stem-cell transplantation (allo-SCT) consolidation after first morphologic complete remission (CR)/CR with incomplete recovery (CRi) (CR1/CR1i) or after second CR/CRi (CR2/CR2i) achieved following first relapse. (oncpracticemanagement.com)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
  • The study population consisted of 784 adults with acute myeloid leukemia in remission or myelodysplastic syndromes undergoing unrelated donor transplant reported to the Center for International Blood and Marrow Transplant Research. (haematologica.org)
  • Disease relapse is the most frequent cause of treatment failure and mortality after hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL). (lls.org)
  • Invasive fungal diseases (IFDs) are common in patients with acute myeloid leukemia (AML), but no recent data on incidence without antifungal prophylaxis are available. (stanford.edu)
  • We report a survival case of invasive splenic mucormycosis involving the liver caused by Rhizopus microsporus in a patient during consolidation therapy for acute monocytic leukemia (AML-M 5 ). (frontiersin.org)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • For chronic or acute liver failure, as well as some cardiorespiratory conditions, the only alternative to transplantation is death. (who.int)
  • Compared with patients transplanted in CR1/CR1i, patients in CR2/CR2i were administered a significantly lower number of chemotherapy cycles prior to allo-SCT (71% of patients received ≥1 cycles from relapse to allo-SCT) than those in CR2/CR2i (61% of patients received ≥2 cycles from diagnosis to allo-SCT). (oncpracticemanagement.com)
  • Caphosol (EUSA Pharma) is a mouth rinse designed to moisten, lubricate and clean the oral cavity including the mucosa of the mouth, tongue and oropharynx which has been shown to prevent and treat oral mucositis in patients receiving radiation therapy or chemotherapy for the treatment of cancer. (wikipedia.org)
  • The results showed that 88% of patients receiving chemotherapy and/or radiotherapy for head and neck cancer who had used Caphosol experienced no or low grade (mild-moderate) oral mucositis, and 44% experienced mild or no oral pain. (wikipedia.org)
  • Patients received a median of 3(range: 2-6) prior chemotherapy regimens (exclusive of tositumomab/iodine-131tositumomab) before or after tositumomab/iodine-131 tositumomab. (cancernetwork.com)
  • Oncogene iASPP enhances self-renewal of hematopoietic stem cells and facilitates their resistance to chemotherapy and irradiation. (nature.com)
  • Moreover, 99% of patients had an ECOG performance status of 0, 3% had secondary CNS lymphoma, 67% were refractory to chemotherapy, and 44% had never achieved a CR. (onclive.com)
  • We evaluated the incidence of IFDs in patients with AML undergoing induction chemotherapy at Stanford University Hospital from 2012 to 2017, for up to 12weeks after induction. (stanford.edu)
  • In spite of the development of growth factors, new broad spectrum antibiotics and antifungal drugs against nearly all known pathogens, severe neutropenia associated with bacterial or invasive fungal infections remains a major cause of morbidity and mortality in patients undergoing aggressive cancer chemotherapy or hematopoietic stem cell transplantation. (elis.sk)
  • In patients undergoing chemotherapy with cyclophosphamide, which is known to cause hemorrhagic cystitis, use of antidotes may have prophylactic benefit. (medscape.com)
  • Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
  • The case-group underwent oral hygiene control associated with the use of chamomile tea before starting the first cycle of chemotherapy, while the control group, there were no previous guidelines and prescriptions. (bvsalud.org)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The impacts of nutritional support should exceed the limits of nutritional status improvement: EN may directly reduce immunological and infectious events, as well as decrease early transplant-related morbidity and mortality. (biomedcentral.com)
  • CONCLUSION: Platelet transfusion efficacy in hematopoietic progenitor cell transplant recipients is markedly influenced by clinical factors specific to the procedure as well as those already recognized in other settings. (elsevierpure.com)
  • The results showed: More than twice as many bone marrow transplant patients avoided oral mucositis by using Caphosol Duration of oral mucositis was almost halved in patients using Caphosol Caphosol patients used 72% less morphine for pain relief, with nearly 75% of patients requiring no morphine at all. (wikipedia.org)
  • Transplant Cell Ther 2021. (harvard.edu)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • 1 Traditional factors used to gauge transplant risks include conditioning regimen intensity, 2 immunosuppression and HLA matching, 3 along with hematopoietic cell source, and graft cell yield. (haematologica.org)
  • 5 4 The importance of patient factors on morbidity and transplant-related mortality (TRM) has gained greater appreciation, particularly in the era of HCT for older and/or more fragile patients. (haematologica.org)
  • 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
  • Epidemiology of lower respiratory tract infections and community-acquired respiratory viruses in patients with bronchiolitis obliterans syndrome after hematopoietic cell transplant: a retrospective cohort study. (stanford.edu)
  • Comparison of Three Distinct Prophylactic Agents Against Invasive Fungal Infections in Patients Undergoing Haplo-identical Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide. (stembook.org)
  • Haploidentical T-cell replete transplantation with post-transplant cyclophosphamide for patients in or above the 6(th) decade of age compared with allogeneic hematopoietic stem cell transplantation from an HLA-matched related or unrelated donor. (stembook.org)
  • The study involved targeted mutational analysis of samples obtained before stem cell transplant from 1,514 MDS patients enrolled at the Center for International Blood and Marrow Transplant Research Repository between 2005 and 2014. (ascopost.com)
  • Opportunistic infections such as cryptococcosis and aspergillosis affect cancer patients , organ transplant recipients , and people with HIV . (cdc.gov)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
  • The overall survival rate for patients who relapsed within 1-year was 4.1% at 3 years after relapse . (bvsalud.org)
  • After multivariable adjustment , statistically significant associations between primary resistance, pre- transplantation measurable residual disease , DNMT3A mutation , or white blood cell count at diagnosis and early relapse were observed. (bvsalud.org)
  • Patients deemed to have a high risk or a low risk of early relapse had early relapse rates of 26.2% and 6.8%, respectively (P (bvsalud.org)
  • The prediction model could be used to help identify patients at risk for early relapse and to guide personalized relapse prevention . (bvsalud.org)
  • We aim to address the unmet need to improve high relapse rate in patients with ALL undergoing hematopoietic cell transplantation (HCT) from a matched or mismatched unrelated/related donors. (lls.org)
  • most patients received nonmyeloablative (66%) conditioning regimens, followed by myeloablative (28%) regimens. (oncpracticemanagement.com)
  • Investigators will assess LP-284 as a treatment for those with B-cell non-Hodgkin lymphoma in a phase 1 trial. (cancernetwork.com)
  • The proposed strategy is design to enhance proliferation, lengthen persistence and augment the anti-lymphoma activity of adoptively transferred CMV-CD19 CAR T cells. (lls.org)
  • The LLS mission: Cure leukemia, lymphoma, Hodgkin disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
  • The European Medicines Agency's Committee for Medicinal Products for Human Use has recommended the approval of lisocabtagene maraleucel for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and follicular lymphoma grade 3B following 2 or more lines of systemic therapy. (onclive.com)
  • liso-cel) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), and follicular lymphoma grade 3B (FL3B) following 2 or more lines of systemic therapy. (onclive.com)
  • Patients who previously underwent hematopoietic stem cell transplantation were permitted, as well as those with secondary central nervous system (CNS) lymphoma. (onclive.com)
  • Checkpoint inhibition before haploidentical transplantation with posttransplant cyclophosphamide in Hodgkin lymphoma. (stembook.org)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • The American Society of Parenteral and Enteral Nutrition (ASPEN) and the French-speaking society of clinical nutrition and metabolism (SFNEP) recommend nutritional support during haematopoietic transplantation for patients who are malnourished or have decreased intake or decreased intestinal absorption over a prolonged period (grade B) [ 11 , 12 ]. (biomedcentral.com)
  • Data related to the patient, the hematological disease, AHSCT and follow-up were collected through clinical and laboratory data. (isth.org)
  • This report describes the epidemiologic, clinical, and For all reported cases of oseltamivir-resistant demographic characteristics of patients with oseltamivir- pandemic (H1N1) 2009 virus infection, epidemiologic data resistant pandemic (H1N1) 2009 virus infections in England were gathered from the responsible clinician by the local and Scotland. (cdc.gov)
  • The safety and efficacy of Caphosol has been demonstrated in a double-blind prospective, randomized clinical trial in patients undergoing bone marrow transplantation. (wikipedia.org)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • Here, we report clinical features and genetic alterations in patients with MNKPL. (confex.com)
  • Fungal endocarditis is often difficult to diagnose because the presentation may be nonspecific, and the disease typically occurs in otherwise critically ill patients with confusing clinical pictures. (medscape.com)
  • Objectives To classify subgroups of cancer-related symptoms in patients with multiple myeloma (MM) during treatment and examine between-group differences in demographic and clinical characteristics in addition to functional status. (bmj.com)
  • The identification of patients with high symptom burden management should focus on the assessment of demographic and clinical characteristics, in addition to functional status. (bmj.com)
  • This study assessed between-group differences in the demographic and clinical characteristics and functional status of patients with MM. (bmj.com)
  • Patient clinical characteristics did not include the evaluation of treatment response. (bmj.com)
  • In some immunocompromised patients, who shed the virus for long periods, the diagnosis can be of little clinical significance. (medscape.com)
  • In a study reported in The New England Journal of Medicine , R. Coleman Lindsley, MD, PhD , of Dana-Farber Cancer Institute, and colleagues found that a number of mutations present in patients with myelodysplastic syndromes (MDS) were associated with poorer clinical outcome after allogeneic hematopoietic stem cell transplantation. (ascopost.com)
  • Catalent is the leading global provider of advanced delivery technologies, development, manufacturing and clinical supply solutions for drugs, biologics, cell and gene therapies and consumer health products. (catalent.com)
  • Mayo Clinic recently announced data on the first clinical use of lenzilumab in 12 patients with severe and critical COVID-19 pneumonia, the majority of whom showed rapid recovery and hospital discharge. (catalent.com)
  • Catalent Biologics' Madison facility provides development and drug substance manufacturing, including GPEx cell line development, process development, process validation, formulation development, and clinical and commercial cGMP manufacturing. (catalent.com)
  • IN8bio is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of gamma-delta T cell product candidates for solid and liquid tumors. (itbusinessnet.com)
  • Therefore, the clinical use of granulocyte trasfusions, as a potential life saving treatment option in patients with severe neutropenia and uncontrolled infection in spite of appropriate antimicrobial therapy should be considered, with regard to possible benefits and risks (Ref. 74). (elis.sk)
  • Avidor Y, Nadu A, Matzkin H. Clinical significance of gross hematuria and its evaluation in patients receiving anticoagulant and aspirin treatment. (medscape.com)
  • Randomized pilot clinical study, with 35 patients assigned to two groups. (bvsalud.org)
  • A recent and high-profile example of this is the recently launched clinical trial for the treatment of Parkinson's disease through stem cell transplantation. (lu.se)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • The primary endpoint will assess the effect of EN on D100 mortality. (biomedcentral.com)
  • In recent years, different studies have reported thromboembolic complications with increased morbidity and bleeding complications with higher mortality in patients undergoing AHSCT. (isth.org)
  • Adjusted 1-year mortality and length of stay were significantly higher in patients with VRE BSI. (wustl.edu)
  • All patients except two who received reduced intensity had severe mucositis.Reversible veno-occlusive disease of the liver also developed in two patients.There was one death from graft-vs-host disease and no regimen-related mortality.Engraftment was prompt, with a median recovery of absolute neutrophil count to ³ 500/µL of 12 days (range: 11-18 days). (cancernetwork.com)
  • Among 55 patients with bronchiolitis obliterans syndrome, 34 (61.8%) developed lower respiratory tract infections, which were associated with impaired lung function and a trend toward increased mortality. (stanford.edu)
  • Mucormycosis is a rare opportunistic fungal infection associated with high mortality that typically occurs in immunocompromised patients. (frontiersin.org)
  • However, when it comes to patient mortality further studies are in need. (tts.org)
  • Majority of patients (97%) were taking newer tri-azole prophylaxis (posaconazole) as per standard centre protocol.Results: Pre-IFD cases were similar to those without pre-IFD in gender, age, disease type, stem cell source, conditioning regimen and donor source whereas conditioning intensity, donor matching and HCTCI scores were significantly different. (kcl.ac.uk)
  • All patients who underwent a related donor AHSCT between 2010 and 2019 at the Miguel Servet University Hospital (Zaragoza, Spain) were included. (isth.org)
  • Intestinal aGvHD can occur after stem cell transplantation when the immune cells of the donor (the graft) consider the recipient's body (the host) as foreign and attack the organs and tissue. (businesswire.com)
  • Four patients were alive withno evidence of disease (three matched unrelated donor and one matched relateddonor). (cancernetwork.com)
  • The aim of their study was to determine whether mismatching weight is an independent risk factor for poor outcome following deceased donor renal transplantation. (tts.org)
  • Percentage weight difference in each transplantation was calculated as follows: (donor weight/recipient weight) × 100. (tts.org)
  • Among seven allogeneic transplants,three received matched related peripheral blood stem cells and four receivedmatched unrelated marrow (n = 3) or peripheral blood (n = 1) stem cells.Allogeneic recipients received tacrolimus and methotrexate for graft-vs-hostdisease prophylaxis. (cancernetwork.com)
  • Six patients relapsed, includingall five autologous and one allogeneic recipients. (cancernetwork.com)
  • PURPOSE OF REVIEW: Fever is a common manifestation of both infectious and noninfectious processes in recipients of hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy. (stanford.edu)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
  • From June 2020 to June 2021, 110 consecutive patients were included prospectively in the validation cohort. (bvsalud.org)
  • Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. (scielo.br)
  • Integrating VRE colonization status with risk factors for developing BSI is a promising method of guiding rational use of empiric anti-VRE antimicrobial therapy in patients with hematological malignancy. (wustl.edu)
  • We propose to develop an innovative adaptive cellular immunotherapy (ACIT) utilizing Chimeric Antigen Receptor (CAR)-engineered T cells, which respond to both CD19+ cells and cytomegalovirus (CMV) antigen, namely CMV-CD19 bi-specific T cells, followed by CMV vaccine to further expand the T cells in vivo. (lls.org)
  • The method entails isolating patient's immune cells (T cells) and genetically engineering them to recognize and kill cancer cells using a Chimeric Antigen Receptor (CAR). (lls.org)
  • BACKGROUND: Platelet transfusion refractoriness remains problematic in the management of patients who have undergone hematopoietic progenitor cell transplantation. (elsevierpure.com)
  • However, a prospective analysis assessing factors affecting platelet transfusion efficacy in the setting of hematopoietic progenitor cell transplantation has yet to be conducted. (elsevierpure.com)
  • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. (nature.com)
  • Most CD8 cells are directed to lytic antigens initially, and these cells rapidly undergo apoptosis ( 7 ). (frontiersin.org)
  • Kok LP. Boon's disease: hemorrhagic cystitis in conjunction with massive exfoliation of degenerated urothelial cells (apoptosis? (medscape.com)
  • Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
  • A latent class analysis was used to categorise cancer-related symptoms in Chinese patients undergoing treatment for multiple myeloma (MM). (bmj.com)
  • Patients were instructed to rinse 4 times per day at the start of cancer treatment and up to 10 times per day if they developed severe oral mucositis. (wikipedia.org)
  • Caphosol has also been associated with low occurrence and severity of oral mucositis in a registry of cancer patients. (wikipedia.org)
  • The registry analysed the effects of Caphosol in head and neck cancer patients along with the frequency of patient dosing, adherence to treatment, and patient and physician global satisfaction assessments. (wikipedia.org)
  • Furthermore, the vast majority of head and neck cancer patients (79%) and physicians (78%) were satisfied with Caphosol as a treatment for mucositis. (wikipedia.org)
  • Efficacy of a supersaturated calcium phosphate oral rinse for the prevention and treatment of oral mucositis in patients receiving high‐dose cancer therapy: a review of current data. (wikipedia.org)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • Interventions The patients were categorised into subgroups based on cancer-related symptoms using a latent class analysis. (bmj.com)
  • Govindarajan Narayanan, MD, speaks to the potential time-saving advantages of using the Epione robot for microwave ablation, cryoablation, and other surgical strategies in patients with liver cancer and other tumors. (cancernetwork.com)
  • If approved, UGN-102 may become the first non-surgical option for patients with low-grade intermediate-risk non-muscle invasive bladder cancer, says Sandip Prasad, MD. (cancernetwork.com)
  • We sincerely thank the patients and investigators for their participation in this study and are committed to helping patients diagnosed with this common and difficult-to-treat type of liver cancer. (merck.com)
  • Eighty-four AML patients with FHL2 and iASPP expression data from The Cancer Genome Atlas database were enrolled in the study. (nature.com)
  • Kreso A, Dick J. Evolution of the cancer stem cell model. (nature.com)
  • LLS funds lifesaving blood cancer research around the world, provides free information and support services, and is the voice for all blood cancer patients seeking access to quality, affordable, coordinated care. (lls.org)
  • Russo P. Urologic emergencies in the cancer patient. (medscape.com)
  • The oral mucositis (OM) represents a frequent inflammatory condition in cancer patients, and poor oral hygiene has been related as a predisposing factor for its onset. (bvsalud.org)
  • Therein lies the ability to repair damaged tissue, inhibit cancer cells, and replace cells or organs that have stopped functioning. (lu.se)
  • Initial control of EBV in healthy persons involves NK cells that can kill virus-infected cells ( 3 , 4 ) and secrete IFN-γ, which inhibits B cell proliferation, and monocytes, which release chemokines in response to virus infection ( 5 ). (frontiersin.org)
  • The median age among the 270 patients who received treatment with liso-cel was 63 years (range, 18-86), with 41% of patients 65 years of age or older and 10% who were 75 years of age or older. (onclive.com)
  • IN8bio's DeltEx platform employs allogeneic, autologous, iPSC and genetically modified approaches to develop cell therapies, designed to effectively identify and eradicate tumor cells. (itbusinessnet.com)
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
  • Recent advances in research give renewed hope that innovative cell therapies may soon be used to treat and cure a range of other chronic diseases. (lu.se)
  • Since opening its doors, Lund Stem Cell Center has played an important role in establishing stem cell research and cell therapies in Sweden and has also played an important role in creating collaborations between researchers and clinicians from around the world. (lu.se)
  • In recent years, adverse effects of antimicrobials have highlighted the importance of antimicrobial stewardship in HCT and CAR-T patients, and an antibiotic de-escalation strategy is a safe and important tool in mitigating these adverse events, even in patients with ongoing neutropenia who become afebrile without a known infection. (stanford.edu)
  • Future work should explore regret in other patient groups and use qualitative methods to inform best practices for reducing regret. (cdc.gov)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • Thrombotic and Hemorrhagic Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation [abstract]. (isth.org)
  • abstract = "Purpose: To identify the most effective dressing for covering long-term central venous catheter exit site to prevent catheter-related infections and skin irritation in patients undergoing hematopoietic stem cell transplantation. (athabascau.ca)
  • ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
  • Primary outcome measures were patient and graft survival. (tts.org)
  • Ongoing assessment of treatment effectiveness is essential for a successful patient outcome. (medscape.com)
  • HLA antibodies with restricted specificitY and platelet antibodies were detected transiently in 17 and 14 percent of the patients, respectively. (elsevierpure.com)
  • Vaccines against SARS-CoV-2 are safe to administer in patients with antibodies to pegaspargase. (stjude.org)
  • These patients have modestly elevated antibodies to EBV lytic antigens as well as antibodies to the EBV nuclear antigens (EBNAs), including EBNA1. (frontiersin.org)
  • There are many more highlights from: xeno to stem cells, antibodies to gamma delta T cells. (tts.org)
  • There were no significant differences in overall survival between patients with or without pre-IFD (p=0.34) in keeping with reported similar survival estimates in EBMT study, although a trend for slightly higher survival beyond 5 years was noted without pre-IFD. (kcl.ac.uk)
  • 87 patients, 53 men, were included for the study. (isth.org)
  • In this study the duration and severity of oral mucositis, and requirements for opioid medication, were evaluated in 95 patients undergoing bone marrow transplantation. (wikipedia.org)
  • I'm excited that this study can contribute to the understanding of this common and life-threatening complication in stem cell transplantation. (businesswire.com)
  • Our Phase 3 study in the prevention of lower GI aGvHD is the latest example of Takeda's commitment to advancing the science of vedolizumab, furthering the understanding of its mechanism of action, and exploring new ways to help patients. (businesswire.com)
  • Results: In this study, 113 patients with SCD were followed up, 92% were classified as HbSS and the rest, divided between HbSC and HbS-β-0. (scielo.br)
  • Conclusion: The current study shows iron sufficiency in most cases of pregnancy with SCA and suggests that evaluation of iron status must be made before initiating iron prophylaxis in pregnant women with SCA, especially in regions having a high prevalence of sickle cell hemoglobinopathy. (scielo.br)
  • The study enrolled 413 patients who were randomized to receive either KEYTRUDA (200 mg fixed dose every three weeks for up to 35 cycles of treatment [up to approximately two years]) plus best supportive care (including pain management and management of other potential complications including ascites per local standards of care) or placebo plus best supportive care. (merck.com)
  • Patients above 20 years of age were recruited in this study. (slideshare.net)
  • A recent study showed that patients with CAEBV or infectious mononucleosis have a decrease in the TCR-beta repertoire and expanded T cell clones in their peripheral blood compared with healthy carriers of EBV ( 14 ). (frontiersin.org)
  • Completion of this study has the potential to improve the progression-free survival in patients with AML. (lls.org)
  • A Phase 3 study is currently underway evaluating hospitalized COVID-19 patients. (catalent.com)
  • During the transplantation process, prophylactic anti-mucormycosis therapy with amphotericin B was continued, and the patient achieved hematopoietic reconstruction. (frontiersin.org)
  • Journal of Stem Cell Research and Transplantation is an international, open access, peer reviewed, scholarly journal committed to publish articles in diversified fields of transplantations and applications of stem cell research. (slideshare.net)
  • The Journal of Stem Cell Research and Transplantation publishes latest scientific information, and is generously accessible across the world through internet to go halves the innovations of the researchers for intellectual advancement in this field. (slideshare.net)
  • For two decades, researchers at Lund University's strategic research area, Lund Stem Cell Center, have focused on developing and refining stem cell research to improve human health. (lu.se)
  • Now that the 20th anniversary is approaching, it is time to reflect on the progress made and the possibilities that researchers see for stem cell research in the future. (lu.se)
  • Stem cell research can revolutionize the treatment, cure, and alleviation of serious diseases. (lu.se)
  • 7 patients had graft-versus-host disease, 6 had BK virus cystitis, and 6 had thrombocytopenia at the time of bleeding. (isth.org)
  • Lately, an interest about granulocyte transfusions was renewed, what is a logical approach in the management of patients with prolonged 'reversible' severe neutropenia and severe infection, which is not controlled with appropriate antimicrobial and supportive treatment, including recombinant hematopoietic growth factors. (elis.sk)
  • Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
  • Within 90 days of liso-cel infusion, 99% of patients experienced any-grade toxicities and 79% experienced grade 3 or higher toxicities. (onclive.com)
  • The cell mediated immune response notably that mediated through cytotoxic T lymphocytes (CTL) is essential in the maintenance of viral latency and the resolution of primary infections. (ucl.ac.uk)
  • KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
  • Both the innate immune response (especially NK cells) and the acquired immune response (virus-specific CD4 and CD8 cells) have a critical role in clearing the infection ( 2 ). (frontiersin.org)
  • We look forward to the European Commission's decision as we continue to accelerate our research in cell therapy to develop new treatment options for patients living with difficult-to-treat blood cancers. (onclive.com)
  • This positive CHMP opinion is an important milestone that recognizes [liso-cel] as a differentiated cell therapy with the potential to address unmet needs for patients in the European Union with aggressive lymphomas who have limited treatment options," Anne Kerber, senior vice president of Cellular Therapy Development at Bristol Myers Squibb, stated in a press release. (onclive.com)
  • Based on these results, it was concluded that MRD status at allo-SCT and the number of remissions prior to transplantation were important independent prognostic factors in patients with AML. (oncpracticemanagement.com)
  • Genetic profiling revealed that molecular subgroups of patients undergoing allogeneic hematopoietic stem-cell transplantation for MDS may inform prognostic stratification and the selection of conditioning regimen. (ascopost.com)
  • Three CVID patients developed CMV disease and were then treated with antiviral therapy. (ucl.ac.uk)
  • Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China. (bvsalud.org)
  • Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
  • KEYTRUDA, Merck's anti-PD-1 therapy, plus best supportive care, for the treatment of patients with advanced hepatocellular carcinoma (HCC) who were previously treated with systemic therapy, did not meet its co-primary endpoints of overall survival (OS) and progression-free survival (PFS) compared with placebo plus best supportive care. (merck.com)
  • As monotherapy in second-line HCC, in addition to KEYNOTE-240 and KEYNOTE-224, KEYTRUDA is being investigated in the ongoing Phase 3, KEYNOTE-394 trial, a randomized, double-blind trial evaluating KEYTRUDA in combination with best supportive care, compared to placebo in combination with best supportive care, in Asian patients with advanced HCC who were previously treated with systemic therapy. (merck.com)
  • ClinicalTrials.gov, NCT02702401 ) evaluating KEYTRUDA plus best supportive care compared to placebo plus best supportive care in patients with advanced HCC who were previously treated with systemic therapy. (merck.com)
  • iASPP is a negative regulator of the apoptotic function of p53, and it can enhance the ability of hematopoietic stem cells to self-renew and resist chemo- and radiation therapy. (nature.com)
  • However, the full potential of CAR T therapy is hampered by the lack of long-term persistence of the engineered T cells in patients. (lls.org)
  • Bridging therapy was permitted during the manufacturing of the CAR T-cell product. (onclive.com)
  • Rapid, reliable diagnostic tests for Aspergillus , when incorporated into patient care pathways, allow for the targeted use of antifungal therapy. (bruker.com)
  • among patients without TP53 mutations, survival was similar among those with therapy-related MDS vs primary MDS (HR = 1.10, P = .37). (ascopost.com)
  • PPM1D mutation vs no mutation was not associated with poorer survival in patients with therapy-related MDS without TP53 mutations (HR = 1.26, P = .39). (ascopost.com)
  • If we are able to secure FDA approvals or Emergency Use Authorization, Catalent Biologics' deep expertise and integrated OneBio solution will accelerate our ability to get this therapy to patients that need it most. (catalent.com)
  • The experience we already have with lenzilumab, and our OneBio integrated offering from development to supply, make Catalent uniquely suited to support Humanigen in the journey to make this promising therapy available to COVID-19 patients as soon as possible following receipt of regulatory approvals. (catalent.com)
  • The patient received liver support therapy, and the serum hepatic enzymes recovered to normal levels. (journaltocs.ac.uk)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Treatment-related adverse events were reported in 24.8% versus 28.4%, and treatment related serious adverse events in 8.5% versus 6.5% of patients treated with placebo versus vedolizumab, respectively. (businesswire.com)
  • Common adverse events associated with antibiotics include an increased risk of Clostridiodes difficile infection (CDI), a higher incidence of multidrug-resistant organisms (MDROs), and microbiome dysbiosis.SUMMARY: Clinicians should be aware of noninfectious causes of fever in these immunocompromised patients and utilize best antibiotic practices while managing these patients. (stanford.edu)
  • Results from a clofarabine-busulfan containing reduced-toxicity conditioning regimen prior to allogeneic stem cell transplantation: the phase II prospective CLORIC trial. (stembook.org)