• High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant (HDC/ABMT or just ABMT), was an ineffective treatment regimen for metastatic breast cancer, and later high-risk breast cancer, that was considered promising during the 1980s and 1990s. (wikipedia.org)
  • 3 The idea for high-dose chemotherapy (HDC) with autologous bone marrow transplant (ABMT) originated in the 1950s as a leukemia treatment, when E. Donnall Thomas had shown that bone marrow could be harvested from a person and transplanted into the same or another person. (wikipedia.org)
  • The treatment of high-dose chemotherapy with autologous bone marrow transplant had serious, lasting, and sometimes deadly side effects for the patient, including cardiac toxicity, sepsis, pulmonary failure, and nephrotoxicity, among others. (wikipedia.org)
  • Fludarabine and melphalan-based conditioning for patients with advanced hematological malignancies relapsing after a previous hematopoietic stem cell transplant. (uchicago.edu)
  • Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
  • Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
  • Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence. (uchicago.edu)
  • Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. (uchicago.edu)
  • Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
  • Clinicopathologic features of late-onset veno-occlusive disease/sinusoidal obstruction syndrome after high dose intravenous busulfan and hematopoietic cell transplant. (uchicago.edu)
  • Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
  • T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. (uchicago.edu)
  • Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
  • 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
  • The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
  • The aim of this study is to measure the differences in quality of life and mood of hematopoietic stem cell transplant (HCT) patients and their caregivers staying at a hospital hospitality house (HHH), such as the Gift of Life Transplant House, the Help in Healing Home, and the Gabriel House of Care versus staying at a hotel/rental apartment or house. (mayo.edu)
  • In research presented in Bone Marrow Transplantation , investigators examined whether the time interval from ending induction therapy to receiving an autologous hematopoietic stem cell transplant (AHSCT) impacted outcomes in patients with multiple myeloma (MM). Lead author, Charalampos Charalampous, MD, noted that the last cycle of induction therapy is typically completed two to four weeks before transplantation. (bloodcancerstoday.com)
  • Based on a retrospective analysis of patients with newly diagnosed MM, Dr. Charalampous and colleagues concluded that a prolonged time to transplant (TTT) was associated with worse outcomes compared with a more rapid schedule. (bloodcancerstoday.com)
  • Bone Marrow Transplant. (bloodcancerstoday.com)
  • Receiving stem cells through this type of transplant replaces the patient's stem cells that may have been harmed by chemotherapy or radiation treatments with healthy stem cells. (cmlalliance.com)
  • Patient the initial transplant, the patient received a second SCT from the same donor after a conditioning regimen with antithymocyte globulin. (cdc.gov)
  • Treatment with activated factor 7 and in a patient with multiple myeloma who had received an allogeneic stem cell transplant requiring substantial corticosteroids was given with some clinical improvement immunosuppression. (cdc.gov)
  • in an hyperbilirubinemia and elevation of liver aminotransferases, immunosuppressed patient who received an allogeneic together with diarrhea, abdominal distension, and new stem cell transplant for multiple myeloma. (cdc.gov)
  • Transplant Cell Ther 2021. (harvard.edu)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
  • Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
  • At the University of Chicago Medicine, our transplant team works side-by-side with the patient, family and referring physician before, during and after transplantation to ensure the best possible outcome. (uchicagomedicine.org)
  • Most patients stay in the hospital during this period to be protected from infection and monitored for side effects, though select patients may be candidates for outpatient stem cell transplant . (uchicagomedicine.org)
  • Post-transplant care - including regular examinations to monitor allogeneic transplant patients for signs of graft vs. host disease (GVHD) and to watch autologous and allogeneic patients for immune system recovery, complications related to chemotherapy or radiation and cancer recurrence (relapse). (uchicagomedicine.org)
  • Select patients may receive outpatient stem cell transplant care in specially designed treatment rooms within the unit. (uchicagomedicine.org)
  • Our stem cell transplant physicians are members of the nationally renowned UChicago Medicine Comprehensive Cancer Center , one of only two National Cancer Institute (NCI)-designated Comprehensive Cancer Centers in Chicago. (uchicagomedicine.org)
  • The Greater Accra Regional Hospital - Ridge's BMT Ghana Transplant Unit has previously handled several bone marrow transplants. (bonemarrowtransplantations.com)
  • The initial step in this kind of transplant is the extraction or harvesting of your stem cells. (bonemarrowtransplantations.com)
  • Stem cells from a donor whose tissue is comparable to yours are used in the most popular allogeneic transplant. (bonemarrowtransplantations.com)
  • What's the Process Involved in a Stem Cell Transplant? (dana-farber.org)
  • A stem cell transplant is an infusion of healthy stem cells. (dana-farber.org)
  • In this case, the transplant replaces the stem cells lost during treatment. (dana-farber.org)
  • This is an autologous transplant. (dana-farber.org)
  • An allogeneic transplant uses stem cells from a donor (related or unrelated to the patient) whose human leukocyte antigens (HLA) are acceptable matches to the patient's. (dana-farber.org)
  • When a patient is identified as a stem cell transplant candidate, the care team will create a treatment plan based on your type of cancer, the type of transplant, and your treatment history. (dana-farber.org)
  • The time it takes to reach engraftment depends on several factors, including stem cell source, the type of transplant, and your pre-transplant therapies. (dana-farber.org)
  • Learn more about the different types of stem cell transplants and stem cell transplant services at Dana-Farber. (dana-farber.org)
  • The National Bone Marrow Transplant Link helps patients, caregivers, and families by providing information and support services before, during, and after transplant. (dana-farber.org)
  • The procedure is based on an autologous bone-marrow transplant (when patients receive a transplant of their own stem cells) and now constitutes a treatment option to cure an intestinal disease that sometimes does not successfully respond to drugs and requires highly complex surgery that does not provide a cure. (sciencedaily.com)
  • With this therapy, in an average follow-up period of 6 years, 80% of transplant patients are in a phase of total remission of the disease and the remaining 20% have shown considerable improvement following the transplant, and are now responding favorably to drugs. (sciencedaily.com)
  • The transplant requires several weeks of admission to hospital before patients receive their own cells. (sciencedaily.com)
  • in Italy, the treatment has been applied to 4 patients, 3 of whom are also showing excellent progress following the transplant. (sciencedaily.com)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • All patients will be treated with a pre-phase rituximab-MTX (R-MTX) cycle followed by re-assessment of transplant eligibility. (biomedcentral.com)
  • Patients judged transplant eligible will be randomized (1:1). (biomedcentral.com)
  • In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
  • The FACT accredited Adult Stem Cell transplant and cellular therapy program has grown to become the largest in the tri-state and among the top ten in the nation. (hackensackmeridianhealth.org)
  • Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (uchicago.edu)
  • Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • Over the next 10 days, despite treatment with broad- fl udarabine and cyclophosphamide), followed by spectrum antimicrobial drugs and corticosteroids, the prophylaxis against graft-versus-host disease (alemtuzumab patient had intermittent fever, continued elevation of liver and cyclosporine). (cdc.gov)
  • HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
  • Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
  • The primary purpose of this study is to estimate and compare overall survival between the two arms: patients who are Very Likely to find a Matched Unrelated Donor (MUD) versus those who are Very Unlikely to find a MUD. (mayo.edu)
  • Allogeneic stem-cell transplants refer to a procedure in which a patient receives stem cells from a donor who is genetically similar to the patient, as defined by the National Cancer Institute. (cmlalliance.com)
  • In such cases, the transplantation procedure is prioritized during the early stages, provided a suitable donor is identified. (medistateinternational.com)
  • The decision to proceed with stem cell transplantation for these conditions hinges on a comprehensive evaluation of the disease's course, severity, donor-related attributes, and procedural risks. (medistateinternational.com)
  • The success of stem cell transplantation pivots on the identification of a donor possessing either a fully-matched or partially-matched tissue group with the patient. (medistateinternational.com)
  • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • However, HLA-identical sibling stem cell infusions in ADA-SCID result in some donor stem cell engraftment and long-term thymopoiesis. (frontiersin.org)
  • She received a matched sibling donor unconditioned stem cell infusion at 16 months of age. (frontiersin.org)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
  • To determine whether antigen-specific immunity, induced in the stem cell donor, can be passively transferred to the allogeneic SCT recipient in the setting of a non-myeloablative conditioning regimen. (drugpatentwatch.com)
  • Identification of the appropriate type of transplantation - autologous (from the patient), syngeneic (from an identical twin), or allogeneic (from a related, unrelated or cord blood donor). (uchicagomedicine.org)
  • Bone marrow stem cells are harvested from the donor in an operating room. (uchicagomedicine.org)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • Donor stem cells are used in allogeneic stem cell transplantation. (bonemarrowtransplantations.com)
  • A stem cell donor undergoes stem cell collection. (dana-farber.org)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • Its severity depends on the differences in tissue type between patient and donor. (drcremers.com)
  • The drying and scarring effects of the attack by the donor cells can affect the inside of the mouth and the esophagus (from the throat to the stomach), causing them to become excessively dry and damaged. (drcremers.com)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • Patients with Burkitt leukemia/lymphoma are treated with regimens specific for this diagnosis. (medscape.com)
  • 3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
  • Several factors hinder the identification of risk factors for central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL), including the retrospective nature of most studies, the relatively low frequency of CNS relapse in DLBCL, and the heterogeneity of CNS prophylaxis methods used in these studies. (haematologica.org)
  • Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
  • To investigate effects of the preautografting administration of rituximab on the mobilization and engraftment of peripheral blood stem cells (PBSC), we retrospectively analyzed the outcomes of 43 newly diagnosed diffuse-large B-cell lymphoma patients who received CHOP chemotherapy with or without rituximab as a first-line treatment before autologous PBSC transplantation (PBSCT). (elsevierpure.com)
  • Specifically, patients with lymphoma who were two to five years post-BMT had reported attending routine check-ups 88% of the time. (cmlalliance.com)
  • For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)
  • [9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challenging due to comorbidities and reduced performance status. (biomedcentral.com)
  • It is used as a form of chemotherapy for malignancies such as lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme. (the-medical-dictionary.com)
  • Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • They then believed that STAMP produced more durable remissions than those by conventional chemotherapy, and so Peters left to set up a randomized clinical trial at Duke University. (wikipedia.org)
  • However, only women who were healthier and responded better to conventional chemotherapy were eligible for the Phase II studies. (wikipedia.org)
  • To belabour the point further Hortobagyi, using data from the University of Texas M. D. Anderson Cancer Center in Houston, reported in May 1995 that those eligible for high-dose chemotherapy survived 65% longer on conventional chemotherapy than those who would not have been eligible for the protocol. (wikipedia.org)
  • Additional information could be provided by computed tomography (CT) and magnetic resonance imaging (MRI), while conventional bone scintigraphy is affected by low sensitivity because of inadequate osteoblastic activity in MM lesions [ 1 - 3 ]. (hindawi.com)
  • All patients initially underwent conventional infertility treatment for 2 consecutive cycles in which the priming group but not controls received a subcutaneous G-CSF priming injection during the early luteal phase. (biomedcentral.com)
  • For certain types of leukemia, conventional chemotherapy methods present a viable treatment avenue. (medistateinternational.com)
  • Often, conventional medical treatment options are limited, leaving stem cell transplantation as a potential game-changer. (medistateinternational.com)
  • To determine the efficacy of a novel conventional chemotherapy regimen (Fludarabine-EPOCH) in the setting multiple myeloma. (drugpatentwatch.com)
  • High-dose chemotherapy and autologous stem cell transplantation (HCT-ASCT) after high-dose methotrexate (MTX)-based immuno-chemotherapy has become an increasingly used treatment approach in eligible elderly PCNSL patients with promising feasibility and efficacy, but has not been compared with conventional chemotherapy approaches. (biomedcentral.com)
  • A randomized controlled trial, incorporating a GA and comparing age-adapted HCT-ASCT treatment with conventional chemotherapy is needed. (biomedcentral.com)
  • The primary objective is to demonstrate that intensified chemotherapy followed by consolidating HCT-ASCT is superior to conventional chemotherapy with rituximab, MTX, procarbazine (R-MP) followed by maintenance with procarbazine in terms of progression free survival (PFS). (biomedcentral.com)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • Patients aged 15-39 years are referred to as "AYA" (adolescent and young adult) and are eligible for more intensive pediatric-style treatment regimens. (medscape.com)
  • Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
  • The following regimens can be used for patients diagnosed with ALL. (medscape.com)
  • For example, George Canellos, one of the original members of the NCI, had noticed that a long-term side effect of megadose chemotherapy regimens was myelodysplasia, a condition that tended to progress to leukemia. (wikipedia.org)
  • The study reviewed the duration and dosing of participants' induction regimens, the date of final chemotherapy, and any biochemical response achieved before transplantation. (bloodcancerstoday.com)
  • With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ∼ 80%, even higher among low-risk patients. (nature.com)
  • 6 , 9 The demonstrated efficacy, lack of myelosuppression, and overall tolerability of thalidomide provide a strong rationale for its incorporation in standard induction regimens for patients presenting with NDMM who may be eligible for ASCT. (haematologica.org)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • Validation of prognostic factors and survival of patients with multiple myeloma in a real-life autologous stem cell transplantation setting: a Swiss single centre experience. (smw.ch)
  • The problem with Phase II studies was explained thus: If you have a hundred patients and you give them a treatment applicable to all 100, and two are alive after 10 years, that is a 2% absolute survival rate. (wikipedia.org)
  • If you have 100 patients and you have a treatment applicable to 20 of the 100, and 20% of those 20 are alive after 10 years, that's only a 4% absolute survival rate, not a 20% survival rate. (wikipedia.org)
  • Cilta-cel improved survival outcomes compared with standard care in patients with lenalidomide-refractory multiple myeloma. (bloodcancerstoday.com)
  • Therapeutic Candidate or Device TriLeukeVax, an autologous AML vaccine designed to stimulate induction of anti-leukemic cytolytic activity and improve relapse free survival (RFS). (ca.gov)
  • Larger studies are required to determine the impact of rituximab on the mobilization and function of PBSC as well as whether a survival advantage exists in patients who undergo auto-PBSCT with rituximab. (elsevierpure.com)
  • A trend toward an overall survival advantage for cyclophosphamide-thalidomide-dexamethasone over cyclophosphamide-vincristine-doxorubicin-dexamethasone was also observed in a subgroup of patients with favorable interphase fluorescence in situ hybridization. (haematologica.org)
  • A study from the Mayo Clinic looked at multiple myeloma patients who were on a beta-blocker while undergoing chemotherapy and found that the use of a beta-blocker resulted in improved patient survival outcomes. (healthtree.org)
  • Stem cell transplants offer some patients the possibility of a cure, and others a longer period of disease-free survival. (dana-farber.org)
  • The 2-year and 5-year survival rates were 72% and 55% in patients with LD and 43% and 0% in patients with extensive disease, respectively. (the-medical-dictionary.com)
  • In patients with limited disease (LD), the CR rate is 16 to 18%, with a median survival of 11.7 to 12.4 months. (the-medical-dictionary.com)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
  • The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
  • BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • The researchers from the study also found that patients who received autologous stem-cell transplants were aged 65 and older and identified as Black, compared with patients who received allogeneic stem-cell transplants. (cmlalliance.com)
  • Autologous stem-cell transplants are when the patient's stem cells are collected and stored before treatment and are returned to the patient after treatment, according to the National Cancer Institute. (cmlalliance.com)
  • Growing technology and facilities for bone marrow transplants in Greater Accra Regional Hospital are enticing patients to receive BMT in their home country rather than fly overseas at a low cost. (bonemarrowtransplantations.com)
  • As a result, the rate of Bone Marrow transplants is lower than in any other developed country. (bonemarrowtransplantations.com)
  • Greater Accra Regional Hospital employs doctors who perform bone marrow transplants utilizing cutting-edge technology and equipment. (bonemarrowtransplantations.com)
  • Stem cell transplants can be a difficult process. (dana-farber.org)
  • The patient was a 33-year-old woman with multiple biopsy samples showed nonspecifi c infl ammation and a myeloma. (cdc.gov)
  • With an overall idea that more is better, this process involved taking cells from the person's bone marrow to store in a lab, then to give such high doses of chemotherapy drugs that the remaining bone marrow was destroyed, and then to inject the cells taken earlier back into the body as replacement. (wikipedia.org)
  • It permits the administration of exceedingly high doses of chemotherapy, a practice that becomes viable due to the subsequent infusion of the patient's own stem cells. (medistateinternational.com)
  • A patient's disease is treated with such high-doses of chemotherapy and/or radiation therapy which destroys cancer and healthy stem cells at the same time. (dana-farber.org)
  • 2016). The high doses of chemotherapy used in al. (bvsalud.org)
  • Shortly after conditioning, LPI levels were increased in 23 patients, with peak at day 0, returning to normal range upon engraftment in 21 patients. (karger.com)
  • Engraftment and recovery - transplanted stem cells begin to grow and reproduce healthy blood cells. (uchicagomedicine.org)
  • While the origin of these tumors is still not definitively known, the two theories with the most support suggest that these tumors arise from a primitive cell derived either from an embryologic tissue called the neural crest, or from resident cells in the body (called mesenchymal stem cells) that have a capability to become one of a variety of tissue types. (sarcomahelp.org)
  • Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
  • The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
  • Randomized clinical trials reported treatment-mortality rates from 0% to 7% for women who received the HDC/BMT treatment, versus no such deaths within the control groups that received the typical chemotherapy regimen. (wikipedia.org)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) is well recognized as a powerful diagnostic tool in the initial staging of patients with multiple myeloma (MM). The aim of this paper is to perform a systematic review about the usefulness of FDG-PET or PET/CT in evaluating the response to treatment in patients with MM. Methods . (hindawi.com)
  • The scientific literature about the role of FDG-PET or PET/CT in evaluating the response to treatment in patients affected by MM was systematically reviewed. (hindawi.com)
  • FDG-PET or PET/CT seems to be helpful in assessing the response to treatment in patients with MM and in the evaluation of possible sites of recurrent or progressive disease. (hindawi.com)
  • Molecular imaging modalities such as Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT have emerged in the recent years as useful methods in the initial staging and treatment planning of patients affected by MM. (hindawi.com)
  • We investigated whether G-CSF priming before treatment with assisted reproductive technology (ART) improved embryo development and pregnancy rate while increasing serum AMH in patients with poor ovarian reserve. (biomedcentral.com)
  • G-CSF priming improved embryonic development and pregnancy rate during ART treatment and increased AMH in patients with poor ovarian reserve. (biomedcentral.com)
  • Research Objective We will use integrated gene editing techniques to develop a new CAR-T cell therapy for multiple myeloma treatment Impact Develop an improved CAR-T cell therapy for patients with refractory multiple myeloma and a new manufacturing strategy that circumvents the costs and inefficiencies of viral production. (ca.gov)
  • Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
  • See "HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets)" and "Evaluation and treatment of hypertensive emergencies in adults" and "Catastrophic antiphospholipid syndrome (CAPS)" and "Early complications of hematopoietic cell transplantation", section on 'Thrombotic microangiopathy' . (medilib.ir)
  • In this regard, the essential hematopoietic stem cells are removed, whilst treatment with the chemotherapeutic agent, the dose of which is elevated by three to five times, takes place. (leading-medicine-guide.com)
  • This complex treatment offers a huge benefit for patients: even more resistant cancer cells are killed by the more intensive treatment process. (leading-medicine-guide.com)
  • Indication AiPSC-RPE cell product will be indicated for the treatment of maculopathies related to RPE atrophy. (ca.gov)
  • The procedure of bone marrow / peripheral stem cell transplantation serves as a pivotal treatment avenue for patients contending with a spectrum of medical challenges. (medistateinternational.com)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
  • Patients with uveitis who are not responding well to steroid treatment and patients who have side effects from other medicines used to treat uveitis (such as cyclosporine, cyclophosphamide, methotrexate or azathioprine) or have refused treatment because of possible side effects of these medicines may be eligible for this study. (drugpatentwatch.com)
  • Stem cell transplantation is a treatment offered through our pioneering cellular therapy program. (uchicagomedicine.org)
  • Conditioning treatment - administration of chemotherapy and/or radiation to the patient in order to destroy all of the diseased cells in the body and to create space in the bone marrow for the transplanted stem cells to populate. (uchicagomedicine.org)
  • WO 2016/135723 to the present inventors discloses mammalian bone marrow cells enriched with mitochondria for treatment of mitochondrial diseases. (justia.com)
  • The treatment for Sickle Cell Disease and other blood problems is bone marrow transplantation, carried out at BMT cost in Greater Accra Regional Hospital. (bonemarrowtransplantations.com)
  • In some cases, stem cells are harvested from a patient's own blood to be transplanted back after conditioning treatment that kills cancerous cells. (dana-farber.org)
  • Patients are admitted to the hospital for conditioning treatment. (dana-farber.org)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • Cellular therapy with stem cells is revolutionizing the focus of treatment of many serious diseases. (sciencedaily.com)
  • To date, a total of 6 patients are benefiting from this new treatment, of whom 3 I've already completed the process and are in the follow-up face, and a further 3 are at different stages of therapy. (sciencedaily.com)
  • Geriatric assessment (GA) may be helpful in selecting patients for the best individual treatment choice, but no standardized GA exists to date. (biomedcentral.com)
  • The best treatment strategy for elderly PCNSL patients remains unknown. (biomedcentral.com)
  • Treatments range from palliative to curative but more toxic therapies, and there is no standardized measure to select patients for the right treatment. (biomedcentral.com)
  • Research to improve the understanding and treatment of cancer is happening in our laboratories and clinics every day as we harness the technology, genetics, immunology, cell biology and bioengineering to diagnose, prevent and treat cancer and other life-threatening and disabling diseases. (hackensackmeridianhealth.org)
  • Combination chemotherapy with cisplatin and etoposide (cisplatin-etoposide [PE]) has long been the mainstay of treatment for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
  • The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
  • Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
  • Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
  • 5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
  • According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
  • Before the mucositis lesions appeared, the patient had been given a treatment protocol that included methotrexate (50mg) at 8-day intervals. (bvsalud.org)
  • Frei and Peters developed the Solid Tumor Autologous Marrow Program (STAMP) regimen. (wikipedia.org)
  • Regimen-related toxicity after fludarabine-melphalan conditioning: a prospective study of 31 patients with hematologic malignancies. (uchicago.edu)
  • Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)
  • One to two days before your stem cell infusion, you'll take a regimen of drugs to help prevent GVHD. (drcremers.com)
  • Comer Children's Hospital pediatric oncology experts are leaders in stem cell transplantation for children and teens. (uchicagomedicine.org)
  • A comparison of discharge strategies after chemotherapy completion in pediatric patients with acute myeloid leukemia: A report from the Children's Oncology Group. (chop.edu)
  • Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
  • Chemotherapy was resumed without any subsequent relapse of hepatic enzyme elevation. (journaltocs.ac.uk)
  • LICs give rise to drug-resistance and relapse and remain unsolved clinical problems in B cell tumors. (ca.gov)
  • In addition, the activation of haematopoiesis after antitumoral therapies could increase bone marrow FDG uptake diffusely. (hindawi.com)
  • Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)
  • Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • The rehabilitation centres should be qualified and experienced because this patient group exhibits problems that differ from those of patients who have undergone oncological therapies or autologous HCT. (mdpi.com)
  • These treatments include antibodies, small molecules and CAR T-cell and other cellular therapies. (hackensackmeridianhealth.org)
  • Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
  • These methods demonstrated a greater diagnostic accuracy compared to whole-body X-ray in diagnosing lytic bone lesions. (hindawi.com)
  • While alternative therapeutic techniques persist, bone marrow/peripheral stem cell transplantation emerges as a transformative option, particularly when other methods display limited efficacy. (medistateinternational.com)
  • Male patients with female partners of child-bearing potential should also use adequate contraceptive methods (see above). (healthtree.org)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • WO 2013/002880 describes compositions and methods comprising bio-energetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures. (justia.com)
  • US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)
  • There was no difference in the number of CD34 + cells among PBSC between the non-rituximab and the rituximab groups. (elsevierpure.com)
  • Although B-cells were completely depleted from PBSC in the rituximab group, we found no difference in the expression of CXCR-4, VLA-4 and c-Kit on PBSC, indicating that rituximab did not affect the expression of these adhesion molecules, which might be involved in the mechanism of mobilization. (elsevierpure.com)
  • Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
  • Surviving longer after transplantation and the belief in lower morbidity led survivors to think that they were cured, the study stated, and Bhatia emphasized that "(every patient) should get a check-up at least once a year after transplantation to prevent any of the bad complications from actually occurring. (cmlalliance.com)
  • Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
  • Research Objective LGR5-antibody drug conjugate to target LIC in B cell tumors that undergo self-renewal Impact LIC were only defined in myeloid leukemia, while LIC populations in B cell tumors remain elusive. (ca.gov)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • From various cancer types like leukemia to congenital or acquired hematologic conditions leading to bone marrow insufficiency and immune system deficiencies, this method addresses diverse health concerns. (medistateinternational.com)
  • Conversely, specific leukemia variants exhibit a limited likelihood of achieving full recovery through chemotherapy alone. (medistateinternational.com)
  • While stem cell transplantation often finds its place in addressing leukemia and cancer cases, its scope extends far beyond these realms, particularly in childhood ailments. (medistateinternational.com)
  • [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
  • Leukemia is a cancer of the blood or bone marrow.It is a form of cancer that affects the body's ability to make healthy blood cells. (rxharun.com)
  • Acute leukemia - is characterized by a rapid increase in the number of immature blood cells. (rxharun.com)
  • Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
  • One subtype is B-cell prolymphocytic leukemia, a more aggressive disease. (rxharun.com)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • Autologous and allogeneic transplantation for aggressive NHL. (uchicago.edu)
  • He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
  • The surgery is occasionally very aggressive for the patient, as it is sometimes necessary to remove the entire colon or large sections of the small intestine, thereby considerably affecting the absorption of food by the intestine, with a resulting deterioration in quality of life and body image (colostomy bag). (sciencedaily.com)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • Patients can also be admitted into clinical trials, which is strongly recommended. (medscape.com)
  • During the early stages of the STAMP clinical trial, the first patients were those who were hopeless cases-women with advanced, metastatic breast cancer that had already received, and did not respond to, existing treatments. (wikipedia.org)
  • The extension of bone marrow and extramedullary involvement should be carefully evaluated to establish prognosis and clinical management [ 4 ]. (hindawi.com)
  • Unfortunately, the term is often used to describe any patient with a TMA who does not have severe ADAMTS13 deficiency or a documented Shiga toxin, therefore it has little clinical usefulness. (medilib.ir)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • This clinical trial investigates the effect of non-chemotherapeutic interventions in patients with multiple myeloma. (healthtree.org)
  • John Theurer Cancer Center is conducting hundreds of clinical trials and is the top enroller of patients in Phase 1 clinical trials in New Jersey. (hackensackmeridianhealth.org)
  • To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
  • Even in terms of diagnostics, it is clear that the Clinic for Haematology, Oncology and Gastroenterology boasts outstanding equipment: the full range of modern investigative techniques is on offer here, including cytological bone marrow diagnostics with special staining. (leading-medicine-guide.com)
  • Scientists are exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease which has considerable impact on the quality of life of the patients. (sciencedaily.com)
  • In this line, Hospital Clínic, Barcelona is exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease that affects 1% of the population in Spain and which has considerable impact on the quality of life of the patients. (sciencedaily.com)
  • Dr. Julián Panés and Dr. Elena Ricart over the Gastroenterology Department of Hospital Clínic, Barcelona are the driving force behind this therapy in Spain and began to implement regenerative cellular therapy in patients with Crohn's disease in August 2008. (sciencedaily.com)
  • Hospital Clínic de Barcelona is one of the few hospitals in the world to instate cellular therapy using autologous stem-cell transplantation. (sciencedaily.com)
  • Researchers identified 1,055 patients diagnosed with MM from 2004 to 2018 who underwent AHSCT within a year of diagnosis. (bloodcancerstoday.com)
  • The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
  • In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
  • Stem cells are located within the bone marrow and are the cells from which all other blood cells and the immune system are created. (dana-farber.org)
  • This is when your transplanted stem cells begin to make new blood (red blood cells, platelets, and other components of the immune system) within your body. (dana-farber.org)
  • The next frontier in cancer, immunotherapy harnesses the immune system to eradicate cancer cells. (hackensackmeridianhealth.org)
  • The aim of this study is to explore intensive care nurses' perceptions and experiences about death and dying patient. (bvsalud.org)
  • Our findings suggest that nurses, particularly those working in intensive care, should be educated/trained on death, and dying patient care. (bvsalud.org)
  • After undergoing an allogeneic haematopoietic stem cell transplantation (alloHCT), patients need intensive physiological and psychological rehabilitation. (mdpi.com)
  • The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
  • They will also undergo a procedure called fluorescein angiography to look at the blood vessels of the eye. (drugpatentwatch.com)
  • Most patients undergoing stem cell transplantation are cared for in our dedicated unit for approximately one week before and two to three weeks after the procedure. (uchicagomedicine.org)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
  • [17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
  • Fifteen patients could receive high-dose ICE followed by PBSCT twice, and 3 patients could receive it once. (the-medical-dictionary.com)
  • I have had patients at nationally ranked, research-based cancer centers and friends and family treated at MSTI. (stlukesonline.org)
  • Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however randomised data about efficacy and safety are missing with curative dose 4 J/cm 2 . (biomedcentral.com)
  • Title: Laser Mucite ORL: Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer (LaserMucite). (biomedcentral.com)
  • Oral mucositis (OM) is one of the most common adverse effects of chemotherapy and radiotherapy, especially for head and neck cancer (HNC). (biomedcentral.com)
  • They look blue to a pathologist because of the staining that is used when identifying the cancer, so the cells are referred to as 'small round blue cells. (sarcomahelp.org)
  • A team at Stanford University is using a molecule known as an antibody to target cancer stem cells. (ca.gov)
  • This antibody can recognize and bind to CD47, a protein the cancer stem cells carry on their cell surface. (ca.gov)
  • Research Objective Our goal is to develop and optimize novel drugs that can attack blood cancer stem cells. (ca.gov)
  • Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
  • Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)
  • O'Brien C, Fogarty E, Walsh C, Dempsey O, Barry M, Kennedy MJ, McCullagh L, , The cost of the inpatient management of febile neutropenia in cancer patients - a micro-costing study in the Irish healthcare setting. (tcd.ie)
  • His specialism relating to conditions of the blood and cancer in particular is undergoing huge development on a scale which is quite rare in the medical world. (leading-medicine-guide.com)
  • In general, chemotherapy is known as the third pillar in treating cancer. (leading-medicine-guide.com)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (merckmanuals.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • New Trials in Prostate Cancer: Could Your Patient Benefit? (nih.gov)