• 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Data have been limited to this point, prompting us to take a closer look at this issue in a larger, more diverse group of autologous and allogeneic transplant survivors over an extended period. (science20.com)
  • Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor Study. (qxmd.com)
  • High-risk patients do not benefit from stem cell transplant and should be offered alternative therapies. (elsevierpure.com)
  • In research presented in Bone Marrow Transplantation , investigators examined whether the time interval from ending induction therapy to receiving an autologous hematopoietic stem cell transplant (AHSCT) impacted outcomes in patients with multiple myeloma (MM). Lead author, Charalampos Charalampous, MD, noted that the last cycle of induction therapy is typically completed two to four weeks before transplantation. (bloodcancerstoday.com)
  • Based on a retrospective analysis of patients with newly diagnosed MM, Dr. Charalampous and colleagues concluded that a prolonged time to transplant (TTT) was associated with worse outcomes compared with a more rapid schedule. (bloodcancerstoday.com)
  • Bone Marrow Transplant. (bloodcancerstoday.com)
  • Viral infection can lead to fatal complications in patients with weakened immune systems resulting from chemotherapy, bone marrow or cord blood transplant, and other forms of inherited or acquired disorders. (ca.gov)
  • A bone marrow transplant (BMT) takes a donor's healthy stem cells and gives them to a patient so they can grow their own healthy red blood cells, white blood cells and platelets. (discovermagazine.com)
  • In this context, patients experience the first psychological conflicts before this transplant. (bvsalud.org)
  • This comprehensive course will enhance your understanding of hematopoietic stem cell transplant (HSCT) and provide concepts to apply to your care of HSCT patients. (ons.org)
  • You'll learn about concepts of HSCT patient care, outcomes, acute and late effects of transplant as well as resources for effective HSCT programs. (ons.org)
  • Up to 4.25 ILNA points may be applied to Basic Concepts for Transplantation OR Early Post-Transplant Management OR Pre-Transplant Care OR Types of Transplants and Sources of Stem Cells. (ons.org)
  • Patient the initial transplant, the patient received a second SCT from the same donor after a conditioning regimen with antithymocyte globulin. (cdc.gov)
  • Treatment with activated factor 7 and in a patient with multiple myeloma who had received an allogeneic stem cell transplant requiring substantial corticosteroids was given with some clinical improvement immunosuppression. (cdc.gov)
  • in an hyperbilirubinemia and elevation of liver aminotransferases, immunosuppressed patient who received an allogeneic together with diarrhea, abdominal distension, and new stem cell transplant for multiple myeloma. (cdc.gov)
  • Coleman Lindsley (right) and Benjamin Ebert work to identify patients with MDS who are likely to benefit from stem cell transplant. (dana-farber.org)
  • Among patients who underwent a stem cell transplant for myelodysplastic syndrome (MDS) - a family of conditions in which bone marrow doesn't produce enough healthy blood cells - outcomes after stem cell transplantation depend on the mutation profile of their disease. (dana-farber.org)
  • In MDS patients without TP53 mutations, those with abnormalities in one of eight "RAS pathway" genes have improved outcome after more intensive pre-transplant conditioning. (dana-farber.org)
  • Another study led by Dana-Farber researchers sought to determine how CHIP - a condition in which patients' blood cells carry acquired mutations associated with blood cancers, but the patients themselves are healthy - affects patient outcomes after an autologous stem cell transplant for non-Hodgkin lymphoma . (dana-farber.org)
  • In another study, Dana-Farber scientists found that when donor stem cells carrying CHIP abnormalities are used in a donor transplant, the abnormalities often remain detectable in the recipient. (dana-farber.org)
  • A treatment known as anti-T lymphocyte globulin (ATLG), in combination with other drugs, reduced the risk of graft-versus-host disease in patients undergoing a donor stem cell transplant. (dana-farber.org)
  • However, this group of patients had a lower overall survival rate than transplant patients who didn't receive ATLG, according to a phase 3 trial led by Dana-Farber researchers. (dana-farber.org)
  • The negative impact occurred mainly in patients who had received a certain conditioning regimen prior to transplant. (dana-farber.org)
  • Transplant Cell Ther 2021. (harvard.edu)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • The transplant of blood stem cells or bone marrow will be infused one to three days after the last chemotherapy or radiation dose. (ucsfhealth.org)
  • Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
  • Blood and bone marrow transplants have been done for decades and have always had risks of complications, like virtually any treatment for serious diseases, but a new study has found an additional one for the list: sexual health. (science20.com)
  • Angiocrine is developing a cell therapy aimed to improve the availability and engraftment of blood stem cell transplants for cancer patients who have had their cancerous bone marrow removed by chemotherapy. (ca.gov)
  • 0.001).DiscussionThe use of AHSCT in people with active SPMS is associated with a slowing of disability progression and a higher likelihood of disability improvement compared with standard immunotherapy.Classification of EvidenceThis study provides Class III evidence that autologous hematopoietic stem cell transplants prolonged the time to CDP compared with other DMTs. (mssm.edu)
  • The Ochsner Leukemia, Blood, and Bone Marrow Transplantation Program is accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) for adults undergoing autologous stem cell transplants. (ochsner.org)
  • Both autologous and allogeneic transplants are performed in our center. (ochsner.org)
  • A randomized clinical trial at Memorial Sloan Kettering Cancer Center (MSK) has shown that fecal microbiota transplants (FMTs) can reestablish the health-promoting bacteria that are often damaged by intense antibiotic treatment in people who have stem cell or bone marrow transplants for blood cancer. (mskcc.org)
  • Earlier work from MSK physician-scientists Eric Pamer, MD, and Marcel van den Brink, MD, PhD , has shown that out-of-balance intestinal microbes can contribute to serious side effects that can affect outcomes after stem cell transplants. (mskcc.org)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of blood and marrow transplants (BMT). (ucsfhealth.org)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • Nonrelapse-related mortality was increased after carmustine (RR = 2.3) and with use of peripheral blood stem cells (RR = 2.4). (qxmd.com)
  • Microangiopathic hemolytic anemia (MAHA) - MAHA is a descriptive term for non-immune hemolysis (ie, Coombs-negative hemolysis) resulting from intravascular red blood cell fragmentation that produces schistocytes on the peripheral blood smear ( picture 1 ) [ 1 ]. (medilib.ir)
  • HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
  • Peripheral blood mononuclear cells were obtained after admission by leukapheresis. (cellsurgicalnetwork.com)
  • The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
  • Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)
  • Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
  • Therapeutic Candidate or Device Hematopoietic stem and progenitor cells collected from X-CGD patients modified with a highly regulated lentiviral vector Indication X-linked Chronic Granulomatous Disease Therapeutic Mechanism Lentiviral vector (LV) modification of autologous hematopoietic stem and progenitor cells (HSPCs) to restore physiologic gp91phox expression. (ca.gov)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Our aim was to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). (biomedcentral.com)
  • Body iron disorders have been reported after myeloablative conditioning in patients undergoing hematopoietic stem cell transplantation (HSCT). (karger.com)
  • In order to better understand the LPI kinetics and its determinants and implications, we undertook sequential LPI determinations before and after conditioning until engraftment in 25 auto-HSCT patients. (karger.com)
  • The risk of IFD in allo-HCT patients is much higher than in auto-HSCT and PHO patients. (viamedica.pl)
  • The second type , allogeneic hematopoietic stem cell transplantation (HSCT), is more common and involves finding a donation from another person. (discovermagazine.com)
  • Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
  • Data were collected between March and September of 2016, through the evaluation of the medical records of 43 patients who underwent HSCT and developed some type of psychological distress. (bvsalud.org)
  • HSCT) has significantly modified the prognosis of when the pathological process involves BM or when patients with hereditary or acquired hematological, hematopoietic toxicity is the limiting factor in the oncological and immunological diseases and it is the aggressive treatment of the disease. (bvsalud.org)
  • Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
  • The learner will apply evidence-based care concepts of hematopoietic stem cell translant into nursing care to improve outcomes for HSCT patients. (ons.org)
  • Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the optimal treatment for pediatric patients with high-risk or intermediate-acute myeloid leukemia. (blood-genomics.com)
  • This study analyzed the clinical outcomes of 119 pediatric acute leukemia patients who underwent haploidentical HSCT ( n =68) or human leukocyte antigen (HLA)-matched HSCT ( n =51). (blood-genomics.com)
  • There was no difference in transplantation-related toxicity (TRT) in terms of infection, hepatic dysfunction, oral mucositis, and engraftment syndrome between the haploidentical HSCT and HLA-matched HSCT groups. (blood-genomics.com)
  • The study suggests that haploidentical HSCT shows comparable OS, LFS, and GRFS to HLA-matched HSCT in pediatric patients with acceptable complications, and can therefore be recommended as an effective alternative for this population. (blood-genomics.com)
  • Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
  • HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)
  • however Keefe et al reviewed the reported toxicity data from 99 published clinical trials including patients with non-Hodgkin lymphoma, breast, lung, or colorectal cancer. (medscape.com)
  • Despite these clinical improvements, the vast majority of patients eventually experience disease relapse and progression. (biomedcentral.com)
  • Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
  • However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
  • Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
  • Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
  • In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
  • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
  • The extension of bone marrow and extramedullary involvement should be carefully evaluated to establish prognosis and clinical management [ 4 ]. (hindawi.com)
  • All he has to do is succeed in his ongoing clinical trials using cell therapy in congestive heart failure. (cellmedicine.com)
  • The U.S. Food and Drug Administration (FDA) has made Amit the only individual in the entire nation to gain its endorsement to undertake clinical trials for treating heart patients by directly injecting adult stem cells into the heart. (cellmedicine.com)
  • The clinical trial for 'Autologous Bone Marrow Progenitor Cell Treatment for Heart Failure,' at the University of Pittsburgh Medical Center is lead by Dr. Amit. (cellmedicine.com)
  • LICs give rise to drug-resistance and relapse and remain unsolved clinical problems in B cell tumors. (ca.gov)
  • To date, the FDA has shown some interest in stem cell therapy, providing approval for several clinical trials that looked at how effective this treatment is in providing a regenerating effect on the impact that certain conditions has in the human body. (stemcellsgroup.com)
  • Unfortunately, the term is often used to describe any patient with a TMA who does not have severe ADAMTS13 deficiency or a documented Shiga toxin, therefore it has little clinical usefulness. (medilib.ir)
  • Recent scientific studies and clinical trials have demonstrated the effectiveness of stem cell therapy in relieving pain and improving joint function in individuals with arthritis. (arthritistreatmentlab.com)
  • In this clinical trial, a team of MSK researchers led by MSK infectious diseases specialist Ying Taur, MD, MPH , explored whether the microbiota could be restored through the use of autologously derived FMTs (meaning the sample comes from the individual undergoing treatment). (mskcc.org)
  • Targeted therapies, new combinations of therapies, and treatments that enhance the immune system's innate cancer-fighting ability are producing solid results in clinical research involving patients who may be resistant to numerous other treatments. (dana-farber.org)
  • In a phase 1 clinical trial, the targeted drug gilteritinib generated prolonged beneficial responses in many patients with relapsed, treatment-resistant AML that carried a mutation in the FLT3 gene, researchers at the University of Pennsylvania reported. (dana-farber.org)
  • The targeted agent venetoclax combined with low doses of the drug cytarabine produced remissions in 70 percent of the elderly patients with AML participating in a phase 2 clinical trial led by Australian scientists. (dana-farber.org)
  • We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
  • The authors confirm chronic graft-versus-host disease (GVHD), a serious complication that occurs when donor cells attack the recipient's cells, as a potential source of sexual dysfunction and say they are the first to demonstrate an association between total body irradiation and sexual dysfunction in men. (science20.com)
  • Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
  • Factors contributing to an increased risk of IFD in allo-HCT patients were: CMV replication, and acute and chronic graft-versus-host disease (GvHD). (viamedica.pl)
  • Over the next 10 days, despite treatment with broad- fl udarabine and cyclophosphamide), followed by spectrum antimicrobial drugs and corticosteroids, the prophylaxis against graft-versus-host disease (alemtuzumab patient had intermittent fever, continued elevation of liver and cyclosporine). (cdc.gov)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • The combination with the pan PI3K inhibitor ZSTK-474 was the most effective in inhibiting the growth of T-ALL cells and was synergistic in decreasing cell survival and inducing apoptosis in nelarabine-resistant T-ALL cells. (bvsalud.org)
  • Anti-CD45 radioimmunotherapy using (211)At with bone marrow transplantation prolongs survival in a disseminated murine leukemia model. (fredhutch.org)
  • Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
  • As blood or bone marrow transplantation survival rates have steadily increased, researchers are seeking to study and maximize survivors' quality of life. (science20.com)
  • Therapeutic Candidate or Device TriLeukeVax, an autologous AML vaccine designed to stimulate induction of anti-leukemic cytolytic activity and improve relapse free survival (RFS). (ca.gov)
  • Survival from IFD was 91.9% in PHO, and 78.1% in HCT patients. (viamedica.pl)
  • The survival of treated patients was statistically higher (P=0.01) than untreated control patients. (cellsurgicalnetwork.com)
  • By analyzing blood samples from more than 400 patients, the researchers found that about 30 percent had CHIP, and that those patients had an increased risk of therapy-related myeloid neoplasms and inferior overall survival. (dana-farber.org)
  • The survival rate in these patients was better than would have been expected with standard therapy. (dana-farber.org)
  • In a trial involving older patients with untreated secondary AML, CPX-351 - an agent that combines the chemotherapy drugs cytarabine and daunorubicin at a 5:1 ratio - produced a longer median survival than did the standard treatment of the drugs in a 7:3 ratio. (dana-farber.org)
  • The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
  • Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
  • The area of research for our group is malignant lymphomas - all possible aspects, aiming for the improvement of the quality of life and survival of these patients. (lu.se)
  • We then studied the combination of nelarabine with the PI3K inhibitors (both pan and dual γ/δ inhibitors), with the Bcl2 specific inhibitor ABT199, and with the MEK inhibitor trametinib on both T-ALL cell lines and patient samples at relapse, which displayed constitutive activation of PI3K signaling and resistance to nelarabine alone. (bvsalud.org)
  • Relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT) remains one of the leading causes of mortality in patients with leukemia. (bvsalud.org)
  • We treated 18 patients with acute leukemia for marrow ± extramedullary relapse after a previous alloHSCT with a myeloablative cytoreductive regimen including clofarabine, melphalan, and thiotepa followed by a second or third transplantation from the same or a different donor. (bvsalud.org)
  • 3 - 5 This report by the Spanish Lymphoma Group (GELTAMO) aims to provide useful guidelines and recommendations for the prevention, diagnosis, and treatment of central nervous system diffuse large B-cell lymphoma patients with, or at risk of, leptomeningeal and/or brain parenchyma lymphoma relapse. (haematologica.org)
  • Several factors hinder the identification of risk factors for central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL), including the retrospective nature of most studies, the relatively low frequency of CNS relapse in DLBCL, and the heterogeneity of CNS prophylaxis methods used in these studies. (haematologica.org)
  • Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)
  • Oral mucositis leads to pain and restriction of oral intake, and, in severe cases (eg, patients undergoing myeloablative therapy prior to HCT), necessitates total parenteral nutrition and increased use of narcotic analgesics. (medscape.com)
  • The procedure involves the transplantation of cells taken either from a patient's own blood or bone marrow (autologous transplantation) or from a matched donor (allogeneic transplantation) which effectively "replaces" damaged cells with healthy cells. (science20.com)
  • Nuclear transfer efficiency is enhanced by introduction of compatible cytoplasm or mitochondrial DNA (same species or similar to donor cell or nucleus). (justia.com)
  • About 70 percent of patients do not have a match within their family and need help from an unrelated donor. (discovermagazine.com)
  • In this process, the donor lays on their stomach so the physician can insert a needle into the iliac crest, located at the back of the pelvic bone. (discovermagazine.com)
  • Depending on the concentration of stem cells in the marrow, the donor would give between 0.5 and 1.5 liters of marrow. (discovermagazine.com)
  • The process begins a few days before donation when the donor is given an injection of granulocyte-colony-stimulating factor to increase the movement of stem cells from the bone marrow into the bloodstream. (discovermagazine.com)
  • The donor's blood is taken from a vein in the arm and travels up a tube into an apheresis machine, removing the stem cells and returning the blood to the donor. (discovermagazine.com)
  • Patients are more likely to match with a donor who has a similar ethnic background. (discovermagazine.com)
  • Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
  • For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The recent emergence of cell-based therapies such as autologous bone marrow-derived mesenchymal stem cells (ABM-MSCs) and mononuclear cells (ABM-MNCs) seems to offer a pragmatic approach to augment β-cell function/mass. (drcalapai.com)
  • Improvement in insulin sensitivity with MSCs and increase in C-peptide response with MNCs provide newer insights in cell-based therapies. (drcalapai.com)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • The present invention provides stem cells enriched with healthy functional mitochondria, and therapeutic methods utilizing such cells for the alleviation of debilitating conditions, including aging, and age-related diseases as well as the debilitating effects of anti-cancer therapies in subjects in need thereof. (justia.com)
  • In addition, the activation of haematopoiesis after antitumoral therapies could increase bone marrow FDG uptake diffusely. (hindawi.com)
  • Routine stem cell therapies for certain types of heart disease will become a reality in 3-5 years according to Dr. Amit of the University of Pittsburgh Medical Center. (cellmedicine.com)
  • Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
  • Many cancers resist current therapies due to therapy-resistant cancer stem cells (CSCs). (ca.gov)
  • Within the last few months, we have seen several concerning publications made by the FDA regarding stem cell therapies, reducing the hope that some patients might have gained. (stemcellsgroup.com)
  • In this study, we compared the effect of AHSCT with that of other anti-inflammatory disease-modifying therapies (DMTs) on long-Term disability worsening in active SPMS.MethodsWe collected data from the Italian Bone Marrow Transplantation Study Group and the Italian Multiple Sclerosis Register. (mssm.edu)
  • Although there are various treatment options available, some patients may not respond to conventional therapies. (arthritistreatmentlab.com)
  • A compound named ABL001, designed to block a key site in the abnormal cell protein BCR-ABL, produced strong responses in a phase 1 trial involving patients with CML that failed to succumb to previous targeted therapies. (dana-farber.org)
  • The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
  • High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • Moreover, none of the patients with an EF less than 50% developed cardiac toxicity. (slideshare.net)
  • Although the occurrence of cardiac toxicity is correlated with a reduction of EF before BMT, life-threatening cardiac toxicity cannot be predicted in individual patients [33]. (slideshare.net)
  • Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
  • Of the NHL patients, 59 (44%) had diffuse large B-cell lymphoma (DLBCL). (smw.ch)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • 211At conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model. (fredhutch.org)
  • Stem cell transplantation is an increasingly effective form of treatment for patients with blood cancer such as leukemia, lymphoma, and myeloma. (science20.com)
  • Angiocrine Bioscience Inc. will use genetically engineered cells, derived from cord blood, to see if they can help alleviate or accelerate recovery from the toxic side effects of chemotherapy for people undergoing treatment for lymphoma and other aggressive cancers of the blood or lymph system. (ca.gov)
  • While lymphoma and leukemia are the conditions where patients most frequently seek a clinic that can perform stem cell therapy on them, there are many other conditions that are treated with this procedure today. (stemcellsgroup.com)
  • For the gene family, see B-cell CLL/lymphoma . (wikipedia.org)
  • [9] If enlarged lymph nodes are caused by infiltrating CLL-type cells, a diagnosis of small lymphocytic lymphoma (SLL) is made. (wikipedia.org)
  • Mantle cell lymphoma (MCL) is a lymphoproliferative disorder derived from a subset of naive pregerminal center cells localized in primary follicles or in the mantle region of secondary follicles. (medscape.com)
  • Mantle cell lymphoma (MCL) is recognized in the Revised European-American Lymphoma and World Health Organization classifications as a distinct clinicopathologic entity. (medscape.com)
  • it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
  • Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
  • See "HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets)" and "Evaluation and treatment of hypertensive emergencies in adults" and "Catastrophic antiphospholipid syndrome (CAPS)" and "Early complications of hematopoietic cell transplantation", section on 'Thrombotic microangiopathy' . (medilib.ir)
  • Most complications can be managed with close attention to the patient and manipulation of the procedure, but some severe reactions and a few deaths have occurred. (msdmanuals.com)
  • He also conducted research on the peritumoral vasculature in head and neck cancer, revealing that patients with metastatic disease were more likely to have high peritumoral blood microvessel density (MVD). (wikipedia.org)
  • There are no routine hematologic or blood chemistry laboratory investigations needed in the workup of a patient with chemotherapy-induced oral mucositis. (medscape.com)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • They further say that this study is one of the longest and is the most inclusive to date evaluating sexual well-being in blood or bone marrow transplantation (stem cell transplantation, SCT) survivors using rigorous, well-validated sexual function assessment tools. (science20.com)
  • median age 48) who underwent SCT at City of Hope for blood cancer between February 2001 and January 2005 about their sexual activity. (science20.com)
  • MM is often discovered through routine blood screening when patients are being evaluated for unrelated problems. (medscape.com)
  • Therapeutic Candidate or Device Autologous blood stem cells edited to restore iduronidase expression Indication Severe Mucopolysaccharidosis Type 1 (MPS1/ Hurler's syndrome) Therapeutic Mechanism Autologous blood stem cells undergo genome editing to restore the production of the missing enzyme. (ca.gov)
  • Research Objective Our research will determine how aging of human blood stem cells leads to dramatic increases in disorders of platelets, cells that normally prevent bleeding but form harmful clots when dysregulated. (ca.gov)
  • Research Objective Our goal is to develop and optimize novel drugs that can attack blood cancer stem cells. (ca.gov)
  • Impact By targeting blood cancer stem cells, these compounds can be used to treat and prevent recurrence of cancer in patients. (ca.gov)
  • By 2012, the Worldwide Network for Blood and Marrow Transplantation, also known as the WBMT, announced that a total of one million stem cell therapy procedures had been done throughout the world. (stemcellsgroup.com)
  • Most donors give stem cells that are harvested from the bloodstream before the blood is returned to the body. (discovermagazine.com)
  • Advocates are calling for more people - especially people of color - to join bone marrow registries to help the 18,000 patients each year who are diagnosed with blood diseases and need donated stem cells. (discovermagazine.com)
  • Historically, blood stem cells were harvested from the bone marrow. (discovermagazine.com)
  • The second and more common option is to take stem cells from the donor's blood. (discovermagazine.com)
  • In addition to joining a bone marrow registry, parents can donate their newborn's umbilical cord blood and the child's part of the placenta. (discovermagazine.com)
  • and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
  • Treatment of blood-related, or hematologic, cancers is seizing on insights into the basic genetic wiring of cancer cells and the body's system for finding and attacking those cells. (dana-farber.org)
  • and 75 percent had a cytogenic response - involving the bone marrow, not just the circulating blood. (dana-farber.org)
  • In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • [2] [9] Enlargement of the spleen and low red blood cells ( anemia ) may also occur. (wikipedia.org)
  • [4] [9] CLL results in the buildup of B cell lymphocytes in the bone marrow, lymph nodes, and blood . (wikipedia.org)
  • [4] These cells do not function well and crowd out healthy blood cells . (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Most people are diagnosed as having CLL based on the result of a routine blood test that shows a high white blood cell count, specifically a large increase in the number of circulating lymphocytes . (wikipedia.org)
  • [17] Less commonly, the disease comes to light only after the cancerous cells overwhelm the bone marrow, resulting in low red blood cells, neutrophils, or platelets. (wikipedia.org)
  • The blood stem cells will be infused through your central venous catheter just like a regular blood transfusion. (ucsfhealth.org)
  • Usually there are no side effects, but occasionally patients may experience chills, flushing of the face, nausea and vomiting, headache, and changes in blood pressure and breathing. (ucsfhealth.org)
  • The stem cells of the transplanted marrow will travel to the bones, reseed the marrow space, and go through a growth process before the mature cells are released from the bone marrow into the blood stream. (ucsfhealth.org)
  • It takes approximately two to three weeks for your marrow to start producing white blood cells, red blood cells and platelets. (ucsfhealth.org)
  • Engraftment is the term used to describe when your new marrow begins to function and produce blood cells. (ucsfhealth.org)
  • While awaiting engraftment, no mature cells leave the marrow and enter the blood stream. (ucsfhealth.org)
  • The goal is to support you with red blood cell and platelet transfusion until you are producing cells again. (ucsfhealth.org)
  • eg, red blood cells [RBCs], platelets, plasma based on specific gravity) to use for transfusion in different patients. (msdmanuals.com)
  • Particularly in hematopoietic cell transplantation (HCT) patients, biopsy is indicated if a deep fungal infection is suspected. (medscape.com)
  • The patient was a 33-year-old woman with multiple biopsy samples showed nonspecifi c infl ammation and a myeloma. (cdc.gov)
  • 184 had no cardiac events after stem cell transplantation. (slideshare.net)
  • Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
  • He is the director of the Center for Cardiac Cell Therapy at the university. (cellmedicine.com)
  • In an earlier study he had shown that "Autologous stem cell transplantation led to significant improvement in cardiac function in patients undergoing off-pump coronary artery bypass grafting for ischemic cardiomyopathy. (cellmedicine.com)
  • In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
  • Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
  • Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being. (qxmd.com)
  • however, Lalla et al, while reviewing published trials for the 2014 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines, found that mucositis occurs in approximately 20-40% of patients receiving conventional chemotherapy and in 80% of patients receiving high-dose chemotherapy. (medscape.com)
  • We analyzed the epidemiology and outcomes of treatment of invasive fungal disease (IFD) in children during anticancer therapy (PHO, pediatric hematology and oncology) or after hematopoietic cell transplantation (HCT) over a period of eight consecutive years in a single-center study. (viamedica.pl)
  • Since 1975, ONS has provided a professional community for oncology nurses, developed evidence-based education programs and treatment information, and advocated for patient care, all in an effort to improve the quality of life and outcomes for patients with cancer and their families. (ons.org)
  • Shortly after conditioning, LPI levels were increased in 23 patients, with peak at day 0, returning to normal range upon engraftment in 21 patients. (karger.com)
  • The presence of inflammatory cytokines after high-dose chemotherapy leads to proliferation and activation of MDSCs originating from autologous hematopoietic progenitors at the time of engraftment. (biomedcentral.com)
  • METHODS: The effectiveness of nelarabine as single agent or in combination with PI3K, Bcl2, and MEK inhibitors was evaluated on human T-ALL cell lines and primary T-ALL refractory/relapsed lymphoblasts. (bvsalud.org)
  • The present invention relates to stem cells enriched with functional mitochondria, and therapeutic methods utilizing such cells to diminish the debilitating effects of various conditions, including aging and age-related diseases as well as the debilitating effects of anti-cancer therapy treatments. (justia.com)
  • WO 2013/002880 describes compositions and methods comprising bio-energetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures. (justia.com)
  • US 20130022666 provides compositions comprising a lipid carrier and mitochondria as well as methods of delivering exogenous mitochondria to a cell and methods of treating or reversing progression of a disorder associated with mitochondrial dysfunction in a mammalian subject in need thereof. (justia.com)
  • Molecular imaging modalities such as Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT have emerged in the recent years as useful methods in the initial staging and treatment planning of patients affected by MM. (hindawi.com)
  • These methods demonstrated a greater diagnostic accuracy compared to whole-body X-ray in diagnosing lytic bone lesions. (hindawi.com)
  • Dr. Coombs discussed the results from a survey of patients with myeloma and APPs who treat myeloma. (bloodcancerstoday.com)
  • It functions by slowing or blocking cell growth and compromising the immune system's response. (ijbs.com)
  • MDSCs are characterized by myeloid origin, immature state, and most importantly by their potent ability to suppress different aspects of immune responses, especially T cell proliferation and cytokine production [ 7 ]. (biomedcentral.com)
  • Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)
  • A team at Children's Hospital of Los Angeles is testing the feasibility of providing these immune suppressed patients with engineered T-cells to fight these viruses. (ca.gov)
  • The cancer cells use that protein to evade the component of our immune system that routinely destroys tumors. (ca.gov)
  • The patient also doesn't have to undergo immune suppression. (discovermagazine.com)
  • Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
  • This radiation therapy is intended to destroy remaining cancer cells and further suppress the immune system. (ucsfhealth.org)
  • Researchers identified 1,055 patients diagnosed with MM from 2004 to 2018 who underwent AHSCT within a year of diagnosis. (bloodcancerstoday.com)
  • In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
  • The donation may require two to three sessions, and donors don't report pain, although the growth factor can cause temporary headaches, joint pain or bone pain. (discovermagazine.com)
  • Problematically, fewer donors of color have signed up with registries, and patients of color are less likely to find a match. (discovermagazine.com)
  • For patients lacking matched sibling donors, haploidentical donors are an option. (blood-genomics.com)
  • Plasmapheresis is often done on healthy donors to obtain plasma only, which is used for transfusion to patients or as a source for plasma derivative preparations (eg, albumin , clotting factor) derived from plasma pooled from thousands of donated units. (msdmanuals.com)
  • Additional processes in which mitochondria are involved include heat production, storage of calcium ions, calcium signaling, programmed cell death (apoptosis) and cellular proliferation. (justia.com)
  • Binds to cell surface receptors on hematopoietic cells and stimulates proliferation, differentiation, and some end-cell functional activation. (hemonc.org)
  • This study aims to examine the efficacy and safety of ABM-MSC and ABM-MNC transplantation in T2DM and explores alterations in glucose-insulin homeostasis by metabolic studies. (drcalapai.com)
  • Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however randomised data about efficacy and safety are missing with curative dose 4 J/cm 2 . (biomedcentral.com)
  • Doxepin hydrochloride in treating oral mucositis pain in patients with head and neck cancer undergoing radiation therapy with or without chemotherapy. (medscape.com)
  • Patients should also be educated about the importance of maintaining good oral hygiene throughout the course of their cancer therapy. (medscape.com)
  • A 78-year-old woman with lung adenocarcinoma and multiple bone metastases received maintenance therapy with pemetrexed + pembrolizumab for a year. (journaltocs.ac.uk)
  • The patient received liver support therapy, and the serum hepatic enzymes recovered to normal levels. (journaltocs.ac.uk)
  • Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
  • As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
  • Increasing evidence indicates that stem cells have the ability of multi-directional differentiation, and it is getting more and more attention that stem cell transplantation serves as a new alternative therapy in repairing damaged myocardium [ 8 ]. (biomedcentral.com)
  • Patients were excluded if they had disease progression during induction therapy were excluded or if they underwent cytoxan pulsing, as that would artificially extend TTT. (bloodcancerstoday.com)
  • Identification of patients at risk of central nervous system disease is critical to accurately identify candidates for central nervous system prophylaxis vs. therapy. (haematologica.org)
  • Stem cell therapy has become a popular type of treatment for a number of conditions, including to assist in the regeneration of injured tissue or diseases cells in the human body. (stemcellsgroup.com)
  • Several advancements have already been made in this medical field, and many had experienced positive results when they underwent stem cell therapy to assist in the treatment of degenerative conditions. (stemcellsgroup.com)
  • While stem cell therapy has been proven to provide an effective protocol in the recovery of stroke, neurological issues, and even to assist in repairing the damage that was dealt by a heart attack, recent reports have caused many to view these treatments in a negative perspective. (stemcellsgroup.com)
  • Even though some have experienced side-effects due to the use of stem cell therapy, it is important to note that there are facilities within the US that can provide professional services that help to minimize the risk of these adverse events. (stemcellsgroup.com)
  • Only one particular treatment that involves stem cell therapy has been officially approved by the Food and Drug Administration , however. (stemcellsgroup.com)
  • While some companies have been found guilty of using unapproved and even misleading products on patients, promoted as stem cell therapy, it is important to consider the reality of the situation as well. (stemcellsgroup.com)
  • Stem cell therapy often referred to simply as Cell therapy, has been proven as a successful regime in the treatment of several conditions. (stemcellsgroup.com)
  • Just in this report, the WBMT refers back to a case of Marta, a girl from Madrid, who had received stem cell therapy at a young age. (stemcellsgroup.com)
  • In 2002, Marta was able to overcome Leukemia, thanks to the cell therapy that was provided to her. (stemcellsgroup.com)
  • He observed that this highly aggressive bone cancer was remarkably sensitive to radiation therapy. (sarcomahelp.org)
  • Stem cell therapy has emerged as a breakthrough treatment option for arthritis. (arthritistreatmentlab.com)
  • While each approach to stem cell therapy has its advantages and limitations, all have shown promising results in improving pain relief, joint function, and overall quality of life in individuals with arthritis. (arthritistreatmentlab.com)
  • [ 2 ] Options for second-line therapy in patients with relapsed/refractory disease include chemotherapy-free regimens with biologic targeted agents such as covalent Bruton tyrosine kinase (BTK) inhibitors, lenalidomide,venetoclax, and chimeric antigen receptor (CAR) T-cell therapy. (medscape.com)
  • The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
  • Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)
  • Research Objective We will develop a biotherapeutic/monoclonal antibody that blocks the growth of human AML cancer stem cells in vitro and in vivo. (ca.gov)
  • Saba is an elected member of the American Head and Neck Society (AHNS) and also specializes in immunotherapy for head and neck cancer, and T cell and B cell activation related to HPV-positive disease. (wikipedia.org)
  • Palifermin reduces the incidence of oral mucositis in patients with metastatic colorectal cancer treated with fluorouracil-based chemotherapy. (medscape.com)
  • Sonis S, Treister N, Chawla S, Demetri G, Haluska F. Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients. (medscape.com)
  • In an interventional study by Rosen et al evaluating patients with colorectal cancer being treated with 5-fluorouracil and leucovorin, the incidence of ulcerative mucositis was approximately 50% in the placebo group. (medscape.com)
  • Large numbers of myeloid-derived suppressor cells (MDSCs), a mixture of monocytic and granulocytic cells, accumulate during many pathologic conditions, including cancer, infectious diseases, trauma, and sepsis. (biomedcentral.com)
  • O'Brien C, Fogarty E, Walsh C, Dempsey O, Barry M, Kennedy MJ, McCullagh L, , The cost of the inpatient management of febile neutropenia in cancer patients - a micro-costing study in the Irish healthcare setting. (tcd.ie)
  • I have had patients at nationally ranked, research-based cancer centers and friends and family treated at MSTI. (stlukesonline.org)
  • A team at Stanford University is using a molecule known as an antibody to target cancer stem cells. (ca.gov)
  • This antibody can recognize and bind to CD47, a protein the cancer stem cells carry on their cell surface. (ca.gov)
  • Impact Treatment of the cancer stem cell driven disease Acute Myelogenous Leukemia (AML) will be impacted. (ca.gov)
  • They look blue to a pathologist because of the staining that is used when identifying the cancer, so the cells are referred to as 'small round blue cells. (sarcomahelp.org)
  • There is a robust outpatient clinic activity with approximately 6000 patients with new cancer diagnoses seen each year. (ochsner.org)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
  • Median time before occurrence of OM ≥ grade 3 in half of the patients was 8 weeks in active laser group (vs. 9 weeks in control group). (biomedcentral.com)
  • Life expectancy of patients diagnosed with new, relapsed-refractory or secondary AML has been improved by drugs targeted at such moieties. (journaltocs.ac.uk)
  • BACKGROUND: Although in recent years, the introduction of novel chemotherapy protocols has improved the outcome of T cell acute lymphoblastic leukemia (T-ALL) patients, refractory and/or relapsing disease remains a foremost concern. (bvsalud.org)
  • In this context, a major contribution was provided by the introduction of the nucleoside analog nelarabine, approved for salvage treatment of T-ALL patients with refractory/relapsed disease. (bvsalud.org)
  • Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)