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  • surgery
  • I do know that patients requiring surgery from the Republic of Ireland have come to the UK for surgery as 1. (arrse.co.uk)
  • According to the study, hard-to-match transplant candidates who receive a new treatment designed to make their bodies more accepting of incompatible organs are twice as likely to survive eight years after transplant surgery as those who stay on dialysis for years waiting for compatible organs. (redorbit.com)
  • Dr. Montgomery believes that the widespread use of a pre-surgery protocol developed at Johns Hopkins, which removes problematic antibodies from a patient's blood prior to transplant, could lead to potentially 3,000 more kidney transplants from living donors each year. (redorbit.com)
  • The pre-surgery process cannot be used at this point with patients receiving cadaver organs because several days of treatment are needed before surgery can take place. (redorbit.com)
  • This process, which conditions the body to accept the new organ, is performed every other day for several days before transplant and then for up to 10 days following the surgery. (redorbit.com)
  • In the new research, the team transplanted 211 HLA-sensitized patients between February 1998 and December 2009 using plasmapheresis and IVIg before and after surgery. (redorbit.com)
  • When a donor organ becomes available, another CMV test takes place hours before surgery so that the transplant team has the most current information about the patient's CMV status. (roche.com)
  • Norris had dozens of surgeries to repair his face, but eventually reached the limits of what conventional surgery could do for him, said Dr. Eduardo Rodriguez, who performed some of those operations and later led the surgical team that performed Norris' face transplant. (yahoo.com)
  • The doctor, who is head of plastic surgery at the University of Maryland Medical Center's R Adams Cowley Shock Trauma Center, had been following advancements in the face transplant field for years. (yahoo.com)
  • The team carefully lays out all of the dangers for patients: Norris' mother, Sandra, remembers Rodriguez saying there was a 50-50 chance her son would survive the surgery. (yahoo.com)
  • A group of MUSC researchers in the College of Medicine's Department of Surgery and the College of Nursing has been awarded a $1.11 million National Institutes of Health grant to examine a novel use of mobile health technology to reduce kidney transplant recipient premature graft loss. (eurekalert.org)
  • John McGillicuddy, M.D., associate professor of surgery in the Division of Transplant Surgery, is leading a collaborative team to study an innovative approach using individually tailored mobile health (mHealth) technology to help patients take their medications as directed and monitor their blood pressure. (eurekalert.org)
  • There are 2,000 to 2,500 heart transplants a year in the U.S. and many people die waiting," says Arman Kilic, M.D., a surgical resident at The Johns Hopkins Hospital and leader of the study published in The Annals of Thoracic Surgery . (medindia.net)
  • Kilic says that nearly half of heart transplant recipients in the study were over 55 and there is debate over how old is too old to undergo the surgery. (medindia.net)
  • The researchers noted that patients who were on ventilators before their transplants were 47 percent more likely to die within 10 years of surgery. (medindia.net)
  • People who require breathing machines before surgery are much sicker than those who do not, so it makes sense that those patients would do poorly, Kilic says. (medindia.net)
  • CHICAGO, Illinois (CNN) -- The woman who received the first-ever near-total face transplant in the United States told her doctor she has regained her self-confidence, said Dr. Maria Siemionow, head of plastic surgery research at the Cleveland Clinic and leader of the transplant team. (cnn.com)
  • The surgery gave the patient a nose with nasal lining, as well as a palate. (cnn.com)
  • Only one of the patients survived after having a synthetic trachea, designed and implanted by Macchiarini, removed during a surgery in Russia in 2014. (thelocal.se)
  • So while there are standard exclusion criteria for some forms of organ transplant -- for example, a patient in need of a liver may be denied a spot on the UNOS waiting list if he cannot abstain from alcohol for six months before surgery -- there are currently no such restrictions for face transplant candidates. (go.com)
  • Although this is the second face transplant Rodriguez has performed at NYU, this surgery is unique in that Cam waited only 18 months after his injury to receive a face transplant. (menshealth.com)
  • Cam also spent less time in the hospital and in rehabilitation after his surgery than the first face transplant performed at NYU Langone. (menshealth.com)
  • centers
  • This kind of accident is unheard of in organ transplant centers and it was a good decision not to use the kidney, Dr. William Harmon, director of kidney transplantation at Boston Children's Hospital, told the Blade. (twincities.com)
  • An Office of Naval Research grant for the purpose of helping wounded warriors made it possible for him and his team to attempt their first face transplant, an operation that previously had been performed by only two other centers in the United States. (yahoo.com)
  • recipient
  • A ) The time course of expansion of pp65 NLV tetramer + cells (right y axis, solid lines, absolute number of CD8 + pp65 NLV + T cells/μl in recipient peripheral blood at days 28, 56, and 80 after HCT) in relation to blood CMV copy number (left y axis, dashed lines) for 3 representative patients. (nih.gov)
  • The pre-transplant test is a blood (serology) test that identifies whether the donor or patient receiving the transplant has already been infected with CMV and provides information about the level of potential risk to the recipient from the virus (see chart). (roche.com)
  • However, even when there is a good donor-recipient immunologic match, the recipient's immune system can attack the transplanted organ's blood vessels. (medindia.net)
  • In addition, the importance of various recipient characteristics to post-transplant survival isn't fully understood. (rxpgnews.com)
  • For the 20,301 patients who remained, including 6,477 with hepatitis C (HCV), he used statistical models to examine the relationship between donor and recipient characteristics and survival after transplant. (rxpgnews.com)
  • For patients with HCV, the best model included the same donor characteristics, and all recipient characteristics except cause of liver disease and serum albumin. (rxpgnews.com)
  • For example, he suggests, "if two donors are expected to be available at approximately the same time, it would be more equitable for the recipient with worse predicted post-transplant survival to receive the donor with the better predicted survival and vice versa since that would make the post transplant survival of the two recipients more similar. (rxpgnews.com)
  • Dr. Guleria further insisted, 'Despite enjoying a high success rate in the transplantation of the kidney from a donor to recipient, a transplant can fail due to multiple reasons. (mid-day.com)
  • The issue of face transplantation garnered renewed interest on Thursday, when James Maki, 59, the country's second-ever face transplant recipient , appeared before reporters and cameras gathered at Brigham and Women's Hospital in Boston. (go.com)
  • donors
  • There were 16,816 kidney transplants nationwide last year from live donors and from those who consented to organ donation through state registries should they die from an illness or accident, the newspaper reported. (twincities.com)
  • Paired donor exchange kidney transplantation is a process in which unrelated kidney donors are matched to recipients so that compatible transplants can be performed. (medindia.net)
  • In view of the hypothesis that NKG2C could be directly involved in NK cell maturation driven by HCMV infection, we analyzed the maturation and function of NK cells developing in three patients with hematological malignancies given umbilical cord blood transplantation from donors carrying a homozygous deletion of the NKG2C gene. (jimmunol.org)
  • acute
  • Our aim was to investigate the effect of acute administration of nitroglycerin in heart-transplanted patients with cyclosporine-induced hypertension. (bioportfolio.com)
  • Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above sea level) on pulmo. (bioportfolio.com)
  • PITTSBURGH - Elizabeth Burns, 14, the nation`s youngest patient to survive a heart-lung transplant, died Thursday of an acute infection, a hospital spokesman said. (chicagotribune.com)
  • stem cell
  • This study will evaluate a treatment regimen that alternates two different 3-drug regimens every eight weeks for patients that have previously completed autologous stem cell transplant. (clinicaltrials.gov)
  • The rate of MRD negativity from this study will be compared to historical control data from the Total Therapy 4 trial which used continuous VRD maintenance therapy after stem cell transplant(s). (clinicaltrials.gov)
  • Patients must have completed a stem cell transplant regimen for newly diagnosed multiple myeloma (MM) consisting of (at least) induction chemotherapy and single or tandem autologous stem cell transplant (ASCT) within eight months of study enrollment. (clinicaltrials.gov)
  • The two most common types of transplants are solid organ transplants and hematopoietic stem cell transplants 5 . (roche.com)
  • Hematopoietic stem cell transplants are used to treat leukaemias, lymphomas and some non-cancerous disorders like severe immunodeficiencies. (roche.com)
  • The type of transplant also affects the CMV risk - lung, heart and multi-organ transplants carry the highest risk, kidney and stem cell transplants the lowest. (roche.com)
  • CAMBRIDGE, Mass.--( BUSINESS WIRE )-- Magenta Therapeutics , a biotechnology company developing novel medicines to bring the curative power of bone marrow transplant to more patients, today announced treatment of the first patient with an inherited metabolic disorder in a Phase 2 study of MGTA-456, an expanded cord blood stem cell product. (biospace.com)
  • MGTA-456 is a first-in-class allogeneic stem cell therapy consisting of a single umbilical cord blood unit expanded with an aryl hydrocarbon receptor (AHR) antagonist then administered to a patient through a bone marrow transplant. (biospace.com)
  • transplantation
  • Norris' 36-hour transplant operation is still considered the most extensive ever conducted because it included transplantation of the teeth, upper and lower jaw, a portion of the tongue and all of the tissue from the scalp to the base of the neck, Rodriguez said. (yahoo.com)
  • More than five million Americans suffer from heart failure and, while the majority of these patients can be managed with lifestyle modifications and medication, for those who suffer from severe, end-stage heart failure, transplantation remains the gold standard treatment. (medindia.net)
  • More than 89,000 patients are waiting for a kidney transplant in the United States, according to the Organ Procurement and Transplantation Network, which is overseen by HHS' Health Resources and Services Administration. (drugs.com)
  • Methods: We included 18 hypertensive patients (HT) scheduled for elective cardiac catheterization after heart transplantation and treated with cyclosporine, as well as 6-matched HT. (bioportfolio.com)
  • We believe transplantation utilizing a larger number of stem cells with MGTA-456 may reduce risk and enhance recovery post transplant, thereby providing these children and their families the best opportunity to achieve an optimal outcome. (biospace.com)
  • The primary endpoint is engraftment after transplantation and the secondary endpoint is transplant-related safety and tolerability. (biospace.com)
  • Poor nutritional status is a common problem in patients waiting for liver transplantation and it is a risk factor for post‐transplant morbidity and mortality. (nih.gov)
  • More research is needed to identify effective nutritional interventions for patients before and after liver transplantation . (nih.gov)
  • The aim of this review was to assess the beneficial and harmful effects of enteral and parenteral nutrition as well as oral nutritional supplements administered to patients before and after liver transplantation . (nih.gov)
  • Randomised clinical trials of parallel or cross‐over design evaluating the beneficial or harmful effects of enteral or parenteral nutrition or oral nutritional supplements for patients before and after liver transplantation were eligible for inclusion. (nih.gov)
  • Adult to child liver transplantation refers to removing a small segment of liver from an adult and transplanting this segment into a child. (medindia.net)
  • People who undergo organ transplantation are always at a risk that their immune system may recognize the transplanted organ as foreign and launch an attack against it. (medindia.net)
  • following transplantation, patients are put on medications to suppress immunity. (medindia.net)
  • Most programs do exclude patients who are non-compliant or not adherent with medical therapy, and most exclude patients who continue to engage in the same behaviors that resulted in end-organ damage -- intravenous drug abuse, continued alcoholism, et cetera," said Dr. David Cronin, director of liver transplantation at Froedtert Memorial Lutheran Hospital in Milwaukee. (go.com)
  • researchers
  • On the day each patient received his or her incompatible transplant, researchers identified five patients on the kidney waiting list who most closely matched the characteristics of the person who got the new organ. (redorbit.com)
  • Examining data from the more than 22,000 American adults who got new hearts between 1987 and 1999, researchers found that roughly half were still alive a decade after being transplanted and further analysis identified factors that appear to predict at least 10 years of life after the operations. (medindia.net)
  • Symptom-specific acupressure points were selected according to patient needs and the massage protocol instructions," report the researchers. (massagemag.com)
  • After the patients were discharged from the hospital, researchers used open-ended interview questions to gather qualitative data about the massage intervention from both parents and practitioners. (massagemag.com)
  • In the first study, researchers found that 16 percent of liver transplant patients with a history of alcoholism started drinking again if they received substance-abuse treatment before and after the transplant. (medicinenet.com)
  • relapse
  • However, some patients still relapse early during maintenance treatment meaning that better options are still needed. (clinicaltrials.gov)
  • The relapse rates were 41 percent for those who received substance-abuse treatment before their transplant and 45 percent for those who received no substance-abuse treatment, according to James Rodrigue, of The Transplant Institute at Beth Israel Deaconess Medical Center in Boston, and colleagues. (medicinenet.com)
  • Immunotherapy agents known as checkpoint inhibitors have shown considerable promise in patients with hematologic cancers who relapse after a transplant with donor stem cells. (medicalxpress.com)
  • infection
  • Transplant patients are among those most vulnerable to CMV infection, especially in the critical few months after the transplant. (roche.com)
  • Between 20% and 60% of people with a solid organ transplant develop a symptomatic CMV infection 4 . (roche.com)
  • Common adverse reactions observed in transplant patients in the trials included low red blood count (anemia), constipation, kidney or bladder infection, and swollen legs, ankles, or feet. (drugs.com)
  • Any transplant patients, including those receiving Nulojix, should limit the amount of time spent in sunlight because of the risk of skin cancer and should not get live vaccines because of the risk of infection. (drugs.com)
  • The Food and Drug Administration has approved a new genetically engineered drug to boost the infection-fighting ability of patients who get transplants of their own bone marrow. (deseretnews.com)
  • Some forms of cancer treatment using radiation and chemotherapy kill the marrow, leaving the patient less able to fight infection. (deseretnews.com)
  • Some of these patients still die of infection in "failed" transplants, estimated at 10 percent to 15 percent of those undertaken. (deseretnews.com)
  • For a patient who has undergone a kidney transplant, diagnosis of any infection is essential at an early stage. (mid-day.com)
  • These receptors allow NK cells to spare HLA class I + autologous normal cells and to kill cells in which HLA class I expression is downregulated (e.g., by tumor transformation or viral infection) or cells expressing non-self HLA class I alleles unable to engage inhibitory KIRs (e.g., in the allogeneic transplant settings). (jimmunol.org)
  • survival
  • Ivanhoe Newswire) -- A new treatment for hard-to-match kidney transplant patients is providing dramatic survival benefits. (redorbit.com)
  • After the first year, each group of patients had about the same chance for survival, in the low 90 percentile range. (redorbit.com)
  • The patients who waited on the list with the possibility of receiving a compatible kidney had a 49.1 percent chance of eight-year survival. (redorbit.com)
  • Despite significant advances in the care of kidney transplant patients, long-term graft survival remains poor, largely due to medications not being taken as directed. (eurekalert.org)
  • HCT has resulted in improved survival rates among children with certain cancers, immune deficiency syndromes or bone marrow failure, but it can be an agonizing ordeal for patients and their families," state the study's authors. (massagemag.com)
  • He then created two models that predict survival after liver transplant one for patients without HCV and one for those with HCV. (rxpgnews.com)
  • PTLD
  • Nulojix carries a Boxed Warning for an increased risk of developing post-transplant lymphoproliferative disorder (PTLD), a type of cancer where white blood cells grow out of control after an organ transplant. (drugs.com)
  • The risk of PTLD is higher for transplant patients who have never been exposed to Epstein-Barr virus (EBV), the cause of mononucleosis. (drugs.com)
  • The side effect of post-transplant lymphoproliferative disorder (PTLD) was more common with the belatacept groups. (medindia.net)
  • world's
  • The world's first partial face transplant was performed in France in 2005 on a woman who was mauled by her dog. (yahoo.com)
  • The surgeon gained worldwide fame in 2011 by carrying out the world's first graft of an artificial plastic trachea, which was to be colonized by the patients' stem cells. (thelocal.se)
  • By the same token, the world's first face transplant patient, Frenchwoman Isabelle Dinoire, in a much-publicized story, continued her smoking habit as her grafted tissue healed. (go.com)
  • Nulojix
  • Nulojix is a new option for kidney transplant patients," said Edward Cox, M.D., M.P.H., director, Office of Antimicrobial Products in the FDA's Center for Drug Evaluation and Research. (drugs.com)
  • Nulojix was evaluated in two open-label, randomized, multicenter, controlled Phase 3 studies that enrolled more than 1,200 patients and compared two dose regimens of Nulojix with another immunosuppressant, cyclosporine. (drugs.com)
  • Patients should be tested for EBV and should only receive Nulojix if the test shows they have already been exposed to EBV. (drugs.com)
  • immunosuppressant
  • After the transplant, patients begin their lifelong immunosuppressant therapy - usually a combination of many different drugs. (roche.com)
  • Of the 27 other transplants that have followed, four recipients have died, and the survivors face a lifetime of immunosuppressant drugs, which can take a toll on their health. (yahoo.com)
  • The immunosuppressant medications carry risks for the patients, who don't know how long the transplant will last. (yahoo.com)
  • He continued, 'Patients are put under strong immunosuppressant medicines to suppress immunity to some extent so that the new kidney can adjust and function in the body. (mid-day.com)
  • immune
  • Apart from the scarcity of donor kidneys, the biggest barrier to kidney transplant right now is the percentage, nearly one in three, of patients on the waiting list whose immune systems make them likely to reject most kidneys available to them," Robert A. Montgomery, M.D., D. Phil. (redorbit.com)
  • Then, the patient receives low-dose intravenous immune globulin (IVIg), which intends to replace those problematic antibodies and prevent their return. (redorbit.com)
  • Several months ago I was switched from prograf (tacrolimus) to rapamune (Sirolimus) for immune suppression roughly a year after liver transplant. (drugs.com)
  • clinical
  • In a single-arm clinical trial, we transplanted 35 patients with high-risk leukemia with TN-depleted PBSC grafts following conditioning with total body irradiation, thiotepa, and fludarabine. (nih.gov)
  • McGillicuddy said Treiber and his colleagues bring expertise in health technology and patient-centered clinical research to the team. (eurekalert.org)
  • MGTA-456 has demonstrated clinical proof of concept in 36 patients with blood cancers, and we are now exploring its potential in patients with inherited metabolic diseases," said John Davis, M.D., M.P.H., chief medical officer, Magenta Therapeutics. (biospace.com)
  • MGTA-456 is currently being studied in a Phase 2 clinical trial in patients with inherited metabolic disorders. (biospace.com)
  • This systematic review of 13 randomised clinical trials found that there is no convincing evidence for beneficial effects of nutritional interventions for livertransplanted patients. (nih.gov)
  • Cam also received counseling from a clinical psychologist, who he still sees, which is important for transplant recipients to ensure they're able to cope with the changes. (menshealth.com)
  • hospitals
  • European law requires that NHS hospitals give EU patients the same access to services as UK patients. (arrse.co.uk)
  • Probably some European law has a specific clause (although nobody can find it) relating to the British NHS that rerequires that NHS hospitals give EU patients and especially immigrants - probably the same access to services as UK patients. (arrse.co.uk)
  • Some other hospitals have begun using it, as well, but many others were awaiting data indicating long-term benefit to patients," Dr. Montgomery said. (redorbit.com)
  • pediatric
  • This data revealed that parent and professional massage may reduce the suffering associated with HCT among pediatric patients and their parent caregivers. (massagemag.com)
  • bone
  • A bone marrow transplant is a process to replace unhealthy bone marrow with healthy bone marrow stem cells. (biospace.com)
  • Currently bone marrow transplant is still associated with risk, toxic side effects, and complexity for patients that could benefit from the procedure. (biospace.com)
  • By creating a platform focused on critical areas of unmet need, Magenta Therapeutics is pioneering an integrated approach to extend the curative power of bone marrow transplant to more patients, by making the process more effective, safer, and easier. (biospace.com)
  • Founded by internationally recognized leaders in bone marrow transplant medicine, Magenta Therapeutics was launched in 2016 by Third Rock Ventures and Atlas Venture and is headquartered in Cambridge, Mass. For more information, please visit www.magentatx.com . (biospace.com)
  • years
  • Patients must be at least 18 years of age and not older than 75 years of age at the time of enrollment. (clinicaltrials.gov)
  • The patient undergoes extensive testing and may spend months, even years, on a transplant waiting list. (roche.com)
  • BALTIMORE (AP) -- In the 15 years between a shotgun blast that ravaged the bottom half of Richard Norris' face and the face transplant that ended a hermit-like life for him, the man from rural southwest Virginia faced cruelty from strangers, fought addiction and contemplated suicide. (yahoo.com)
  • Those 10 years of hell I lived through, it has given me such a wealth of knowledge," Norris recently told The Associated Press, one of only two news outlets granted interviews since his transplant last year. (yahoo.com)
  • Kilic and his colleagues used information collected by the United Network of Organ Sharing (UNOS) and compared the 9,404 heart transplant recipients who survived for 10 or more years with the 10,373 who did not. (medindia.net)
  • In addition, diabetics were one-third more likely to die within 10 years of transplant. (medindia.net)
  • Siemionow, who has been working on face transplant research for 20 years, received approval from the Institutional Review Board in 2004 to conduct a full facial transplant. (cnn.com)
  • With the number of people on the liver transplant waiting list increasing every day, the wait for a liver transplant can take months or even years. (upmc.com)
  • common
  • At this point, the patient doesn't want to face the 'common world,' but she is facing her family, the surgeon said. (cnn.com)
  • Thorough care should be taken to prevent the patient from getting exposed to viral, fungal, or bacterial infections, even common cold or flu. (mid-day.com)
  • surgeon
  • European news media recently reported that a surgeon in Spain received approval for another face transplant, which would be the fifth in the world. (cnn.com)
  • A seventh patient of Italian surgeon Paolo Macchiarini, who was fired from a Swedish university over accusations of misconduct, has died. (thelocal.se)
  • survive
  • and white patients were 35 percent more likely to survive a decade than minority patients. (medindia.net)
  • Under current regulations and policies, UNOS gives available hearts to the sickest patients on its national waiting list, typically those whose doctors predict they will not survive a month without a new organ. (medindia.net)
  • Kilic agrees with the policies, but suggests it may be useful to give priority within this sickest group to patients who using his data would likely survive the longest. (medindia.net)
  • treatment
  • Now, at 38, he's starting a new life: taking online classes in pursuit of a degree in information systems and contemplating a foundation to help defray future transplant patients' everyday expenses during treatment. (yahoo.com)
  • The study evaluates the technique of non-drug treatment of residual pulmonary hypertension in patients with chronic thromboembolic pulmonary hypertension after pulmonary thromboendarterect. (bioportfolio.com)
  • Doctors sometimes take marrow from such patients, store it during treatment, then re-inject it. (deseretnews.com)
  • Because of the ability of MGTA-456 to significantly expand a single cord blood unit into higher cell doses, which increases the likelihood and speed of engraftment, we believe it will represent a compelling treatment option for these patients. (biospace.com)
  • A transplant is not any longer a treatment to save a life momentarily. (medindia.net)
  • It is a treatment to give an excellent quality of life back to our patients. (medindia.net)
  • predict
  • They help predict which patients have the best chance to derive the longest and most sustainable benefit from the limited number of hearts that become available each year. (medindia.net)
  • blood
  • TUCSON - A young car mechanic who endured two heart transplants and 11 hours on a stopgap artificial blood pump died at 1:20 p.m. today, doctors at the University of Arizona Medical Center said. (latimes.com)
  • The new protocol removes the problem antibodies from the blood before the transplant takes place through plasmapheresis, a process that removes, filters, and replaces a patient's plasma supply. (redorbit.com)
  • For people needing an organ transplant, testing provides essential information about the urgency of the need for the organ, the patient's blood and tissue type, and body size - this data helps the donor computer programme find the best match. (roche.com)
  • An initial study showed patients using the mobile technology dramatically improved their medication adherence and blood pressure levels, but the study was too small to show an impact on the kidney graft. (eurekalert.org)
  • In these patients, the secretion of LG3 by the new kidney stimulates the activity of these antibodies which attack and injure the blood vessels of the transplanted organ. (medindia.net)
  • The objective of the present study is to assess blood coagulation disorders in patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. (bioportfolio.com)
  • Leading a healthy life by controlling weight through regular exercise, low salt diet, and with blood pressure medicines can together help a patient manage blood pressure', said Dr. Guleria. (mid-day.com)