Patients study of epirubicin. Medical search. Frequent questions

The incidence and severity was highest in patients receiving trastuzumab with anthracycline-containing chemotherapy regimens. (rxlist.com)
Epirubicin is an anthracycline drug used for chemotherapy. (wikipedia.org)
Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)
We investigated whether the use of ACEI/ARBs affects the clinical outcomes of primary breast cancer patients receiving taxane and anthracycline-based neoadjuvant chemotherapy. (jcancer.org)
We included 1449 patients with diagnosis of invasive primary breast cancer diagnosed at the MD Anderson Cancer Center between 1995 and 2007 who underwent neoadjuvant chemotherapy. (jcancer.org)
No differences in pCR and survival outcomes were seen between ACEI/ARB users and non-users among breast cancer patients receiving neoadjuvant chemotherapy. (jcancer.org)
A venous port was implanted, and 4 courses of rituximab (anti-CD20 monoclonal antibody) plus additional chemotherapy (cyclophosphamide, epirubicin, vicristine and prednisolone) were administered from December 2006 through May 2007. (cdc.gov)
This staging system was used to select the appropriate treatment regimen: chemotherapy in combination with thoracic radiotherapy in patients with LS-SCLC, and chemotherapy alone in patients with ES-SCLC. (ersjournals.com)
If left untreated, patients with SCLC rarely survive longer than a few months 5 , but chemotherapy dramatically prolongs survival compared to the best supportive care 6 . (ersjournals.com)
This has important clinical implications as, in contrast to advanced-stage NSCLC, chemotherapy can also be offered to patients with SCLC and a poor or bad performance status (World Health Organization performance status of 2-3), since a rapid amelioration of the patient's symptoms and general condition can be expected together with an improved outcome 7 . (ersjournals.com)
But this study suggests such tactics may actually be working against the chemotherapy. (naturalmedicinejournal.com)
The study enrolled 60 breast cancer patients who had undergone surgical resection of the tumor and lymph nodes and received adjuvant chemotherapy. (naturalmedicinejournal.com)
All participants received the same chemotherapy FEC-60 (fluorouracil 600 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 600 mg/m2 every 21 days for 6 cycles). (naturalmedicinejournal.com)
On day 14 of chemotherapy, a significant increase of the La/Ma ratio occurred in patients with diarrhea compared to patients without it. (naturalmedicinejournal.com)
[1] Although chemotherapy has improved outcomes for patients, the marginal benefits achieved with cytotoxic agents seem to have reached a plateau. (carcinogenesis.com)
The FDA has accepted and granted priority review for a new sBLA seeking accelerated approval for pembrolizumab in combination with chemotherapy for the treatment of patients with locally recurrent unresectable or metastatic TNBC whose tumors express PD-L1 (combined positive score [CPS] ≥10). (cancernetwork.com)
In addition, the FDA accepted for standard review a new sBLA for pembrolizumab for the treatment of patients with high-risk early-stage TNBC, in combination with chemotherapy as neoadjuvant treatment, and then as a single agent as adjuvant treatment after surgery, based on findings from the phase 3 KEYNOTE-522 trial. (cancernetwork.com)
In total, 847 patients were enrolled and randomized 2:1 to receive 200 mg of pembrolizumab every 3 weeks plus investigator's choice of chemotherapy or placebo plus nab-paclitaxel, paclitaxel, or gemcitabine/carboplatin. (cancernetwork.com)
Pembrolizumab plus chemotherapy demonstrated a statistically significant and clinically meaningful improvement in PFS compared with chemotherapy alone in patients whose tumors expressed PD-L1 at CPS ≥10. (cancernetwork.com)
In the randomized, double-blinded, phase 3 KEYNOTE-522 trial, pembrolizumab was evaluated in combination with chemotherapy compared with placebo plus chemotherapy as neoadjuvant therapy, followed by pembrolizumab monotherapy compared with placebo as adjuvant therapy in patients with TNBC. (cancernetwork.com)
And other studies have shown how certain chemotherapy drugs, for example anthracyclines, such as doxorubicin or epirubicin, or drugs such as cyclophosphamide, can damage the left ventricle of the heart, causing lowered levels of blood to be pumped. (canceractive.com)
As an author of the study (1), he was well aware that chemotherapy drugs could cause dysfunction in the left ventricle, more so if radiotherapy to the chest was used. (canceractive.com)
The effect of post-Cx% on survival outcomes adjusted for the types of chemotherapy and patient characteristics was evaluated by meta-regression. (deepdyve.com)
Trials include participation in the national breast cancer study groups, ECOG and NSABP, as well as the development of new chemotherapy programs. (stanford.edu)
The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)
The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
The study will also evaluate the toxic effects of the chemotherapy combination, including effects on the heart, and will determine survival and progression-free survival 5 years after treatment. (stanford.edu)
In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
Studies that have evaluated the role of multimodality treatment options for these patients include postoperative chemoradiation and perioperative chemotherapy. (medscape.com)
[ 24 ] The MAGIC (Medical Research Council Adjuvant Gastric Infusional Chemotherapy) trial showed that patients treated with perioperative epirubicin, cisplatin, and 5-fluorouracil had a significantly higher overall survival rate compared with patients treated with surgery alone. (medscape.com)
therefore, trastuzumab in combination with chemotherapy is a treatment option for patients with HER2-positive advanced gastric cancer. (medscape.com)
Returning to this case, the patient was scheduled to begin chemotherapy with a combination of capecitabine and oxaliplatin. (medscape.com)
In February 1998 she joined the CRCTU as a Trial Coordinator coordinating a national, multicentre, phase III, trial called SECRAB which was designed to determine the optimal sequence of chemotherapy and radiotherapy in patients with early breast cancer. (birmingham.ac.uk)
In studies, breast cancer was half as likely to come back in patients who received Herceptin than in patients who received chemotherapy alone. (columbian.com)
Adding panitumumab to a carboplatin-containing neoadjuvant chemotherapy regimen yielded a higher rate of pathologic complete response (pCR) in patients with triple-negative inflammatory breast cancer (IBC), a small study found. (medpagetoday.com)
The authors noted that the current study is the first to indicate that an anti-EGFR antibody may enhance sensitivity to neoadjuvant chemotherapy. (medpagetoday.com)
A randomized phase II trial is currently ongoing, testing the carboplatin-containing chemotherapy used in the study with or without the EGFR inhibitor panitumumab in patients with triple-negative IBC. (medpagetoday.com)
A preliminarily study of carcinogenesis and chemosensitivity suggests that this cell model carries a tumor suppressor gene mutation and is sensitive to chemotherapy drugs. (oncotarget.com)
BACKGROUND: Adjuvant chemotherapy for patients with early breast cancer improves outcomes but its toxicity affects patients' quality of life (QOL). (icr.ac.uk)
In the largest trial so far to be conducted in frail elderly patients with advanced gastroesophageal cancer, a lower dose of chemotherapy produced similar outcomes but with less toxicity than the standard dose used for patients with this condition. (medscape.com)
Many elderly or frail patients are unable to tolerate the standard combination chemotherapy regimen, he said. (medscape.com)
The influence of adjuvant chemotherapy on the survival of gastric adenocarcinoma patients in a stage-specific manner is controversial. (springeropen.com)
To further explore this topic, we retrospectively analyzed the impact of adjuvant chemotherapy on the clinical outcomes of 77 stage II and 117 stage III patients diagnosed between January 2008 and December 2012. (springeropen.com)
Higher overall survival from adjuvant chemotherapy in stage II patients with node involvement did not reach the level of statistical significance ( P = 0.102). (springeropen.com)
75 years were included in a subgroup analysis in which the benefit of adjuvant chemotherapy on relapse-free survival and overall survival were demonstrated for patients with stage III disease. (springeropen.com)
Adjuvant chemotherapy prolongs relapse-free and overall survival for patients with stage III gastric cancer in a real-world situation. (springeropen.com)
Data from a recent randomized trial enrolling only patients with II-IIIB gastric cancer revealed a 36 % recurrence rate in 5 years for patients without adjuvant chemotherapy after D2 dissection (Noh et al. (springeropen.com)
Before 2000, there was no large-scaled randomized phase III trial to evaluate the benefit of adjuvant chemotherapy on the survival of patients with gastric cancer after operation. (springeropen.com)
Although some meta-analyses suggested a positive effect of adjuvant chemotherapy on survival of patients with gastric cancer (Hejna et al. (springeropen.com)
Some studies suggested that adjuvant chemotherapy only be recommended for patients with positive lymph node (Earle and Maroun 1999 ), or not recommended because the benefit was small (Janunger et al. (springeropen.com)
The aim of this study is to evaluate the prognostic factors of the group who received neoadjuvant chemotherapy with a taxane-anthracycline combination regimen. (kjco.org)
We retrospectively analyzed for locally advanced breast cancer patients who received neoadjuvant chemotherapy with adjuvant extension with taxane-anthracycline combination regimen. (kjco.org)
101 patients received neoadjuvant chemotherapy with docetaxel and doxorubicin, 46 patients received with epirubicin and paclitaxel. (kjco.org)
In order to predict an oncologic outcome from locally advanced breast cancer patients who are treated with neoadjuvant chemotherapy with taxane-anthracycline based regimen, we can use pathologic complete response, an early response to neoadjuvant chemotherapy. (kjco.org)
Neoadjuvant chemotherapy (NC) is a standard therapy for locally advanced breast cancer patients [ 1 ]. (kjco.org)
Many studies have reported that there are no differences in the oncologic outcomes between NC and adjuvant chemotherapy [ 2 ]. (kjco.org)
If the bone marrow has between 5% and 20% blasts (higher-risk MDS), patients are discussed with the hematopoietic stem cell transplantation (HSCT) team for consideration to receive chemotherapy before HSCT. (sparkcures.com)
Patients must have recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, HSCT or radiotherapy prior to entering this study. (sparkcures.com)
1. Myelosuppressive chemotherapy: Must not have received myelosuppressive chemotherapy within 3 weeks of entry onto this study (excluding hydroxyurea). (sparkcures.com)
Purpose: To evaluate the activity and toxicity of the combination of paclitaxel given by three-hour infusion, and carboplatin as first- line chemotherapy in patients with advanced breast cancer (ABC). (ucy.ac.cy)
Subsequently, 13 patients (61.9%) successfully received systemic chemotherapy. (hindawi.com)
PSE with selective TACE made it possible for patients with HCC and severe thrombocytopenia to receive systemic chemotherapy. (hindawi.com)
9 weeks vs 1 year adjuvant trastuzumab in combination with chemotherapy: final results of the phase III randomized Short-HER study. (unimore.it)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
To assess the feasibility of QOL assessment in a cohort of Tunisian cancer patients, the EORTC QLQ-C30 questionnaire was administered to 23 women treated with adjuvant chemotherapy for early breast cancer on an outpatient basis at baseline and during the 3rd cycle of chemotherapy. (who.int)

Pathological response to neoadjuvant 5-FU, oxaliplatin, and docetaxel (FLOT) versus epirubicin, cisplatin, and 5-FU (ECF) in patients with locally advanced, resectable gastric/esophagogastric junction (EGJ) cancer: Data from the phase II part of the FLOT4 phase III study of the AIO. (springermedizin.at)
Sequential Treatment with Epirubicin/Cyclophosphamide, Followed by Docetaxel vs. FEC120 in the Adjuvant Treatment of Breast Cancer Patients with Extensive Lymph Node Involvement: Final Survival Analysis of the German ADEBAR Phase Ill Study. (uni-koeln.de)
This study sought to retrospectively characterize outcomes for patients with node-negative and node-positive breast cancer receiving adjuvant trastuzumab in combination with docetaxel/cyclophosphamide (DCH), docetaxel/carboplatin/trastuzumab (TCH), or fluorouracil/epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (FEC-DH) chemotherapy in Alberta, Canada, from 2007 through 2014. (jnccn.org)
Concurrent weekly epirubicin and docetaxel was the NAC regimen. (bvsalud.org)
BACKGROUND:The correlation of the oncological outcomes of docetaxel and cabazitaxel in Japanese metastatic castration-resistant prostate cancer (mCRPC) patients has not been unclear. (shengsci.com)
MATERIALS AND METHODS:This study included a total of 47 consecutive Japanese mCRPC patients treated with cabazitaxel and assessed the prognostic significance of cabazitaxel, focusing on patient age and the correlation of efficacy between docetaxel and cabazitaxel. (shengsci.com)
A 30% PSA response to cabazitaxel was achieved in 13 (46.4%) and 7 (36.8%) patients with and without that to docetaxel, respectively. (shengsci.com)
A 30% PSA response to cabazitaxel was achieved in 5 (16.6%) and 7 (41.2%) patients who had treated with less than 10 cycles docetaxel or 10 ≦ cycles, respectively. (shengsci.com)
Univariate and multivariate analyses revealed that there were no significant correlation of patient age (p = 0.537), the response to prior docetaxel therapy (p = 0.339) or cycles of docetaxel therapy (p = 0.379) with shorter OS. (shengsci.com)
CONCLUSION:These results indicate that the introduction of cabazitaxel for Japanese mCRPC patients could result in oncological outcomes without any association with patient's age and the profiles of previous docetaxel therapy. (shengsci.com)

In comparison to this the Epirubicin therapy contains fluorouracil/epirubicin/cyclophosphamide (FEC). (wikipedia.org)
Three large randomized studies have directly compared the epirubicin-containing regimen fluorouracil/epirubicin/cyclophosphamide (FEC) with CMF in the adjuvant setting. (wikipedia.org)
The effects of fluorouracil, epirubicin, and cyclophosphamide (FEC60) on the intestinal barrier function and gut peptides in breast cancer patients: an observational study. (naturalmedicinejournal.com)
Multicenter phase III comparison of cisplatin/S-1 with cisplatin/infusional fluorouracil in advanced gastric or gastroesophageal adenocarcinoma study: the FLAGS trial. (springermedizin.at)
Many studies have reported anthracycline-based regimens increase the benefits compared to cyclophosphamide, methotrexate, and fluorouracil combinations. (kjco.org)
As with other cytotoxic agents, Epirubicin Hydrochloride Injection at the recommended dose in combination with cyclophosphamide and fluorouracil can produce severe leukopenia and neutropenia. (recallguide.org)
HER complexes were analyzed by PLA in a further 321 tumours from the BR9601 trial comparing cyclophosphamide, methotrexate and fluorouracil (CMF) with epirubicin followed by CMF (epi-CMF). (ed.ac.uk)
Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)

It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. (wikipedia.org)
It was also more effective than a three-drug regimen that included epirubicin ( Ellence , Pfizer) in addition to oxaliplatin and capecitabine. (medscape.com)

Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)
Background: The aim of this retrospective study was to present the epidemiological, pathological and clinical characteristics and treatment results of Greek women with epithelial ovarian cancer (EOC). (ucy.ac.cy)
4-Demethoxydaunorubicin (IMI-30) in refractory epithelial ovarian cancer: a pilot study. (unimore.it)

The purpose of the study was to investigate the antitumour activity and toxicity of high dose (120 mg m-2) single agent epirubicin therapy in untreated extensive small cell lung cancer patients. (nih.gov)

A previous retrospective study reported a 12.4% rate of pCR among 139 triple-negative IBC patients specifically, though this study used an anthracycline-containing regimen. (medpagetoday.com)
A combination of capecitabine and oxaliplatin is a commonly used regimen in my clinic, and to know that we can reduce doses without sacrificing benefit will allow me to give this therapy to more patients than before," he said. (medscape.com)
That regimen proved to be too toxic in this patient population. (medscape.com)

In-depth characterization analysis of Penl1 cell line revealed tumorigenicity in immunodeficient mice, negative human papilloma virus (HPV) and mycoplasma infection, TP53 mutations and sensitivity to cisplatin and epirubicin. (oncotarget.com)

Out of 80 patients entered, 71 were evaluable for both antitumour activity and toxicity, 4 only for toxicity and 5 were lost for follow-up. (nih.gov)
The high antitumour activity and no increase in toxicity justify the incorporation of high dose epirubicin into combination therapy. (nih.gov)
Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. (wikipedia.org)
However, the risk of toxicity is greater in this group than in patients with good performance status. (ersjournals.com)
Nine patients died on study (one of which was deemed to be treatment related), and three patients ceased treatment due to toxicity or distant metastasis. (medpagetoday.com)
BACKGROUND: This study was designed to identify common genetic susceptibility and shared genetic variants associated with acute radiation-induced toxicity across 4 cancer types (prostate, head and neck, breast, and lung). (icr.ac.uk)
A dose-dependent, reversible leukopenia and/or neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin and represents the most common acute dose-limiting toxicity of this drug. (recallguide.org)
Early cardiac toxicity of epirubicin consists mainly of sinus tachycardia and/or ECG abnormalities such as non-specific ST-T wave changes, but tachyarrhythmias, including premature ventricular contractions and ventricular tachycardia, bradycardia, as well as atrioventricular and bundle-branch block have also been reported. (recallguide.org)
This toxicity appears to be dependent on the cumulative dose of Epirubicin Hydrochloride Injection and represents the cumulative dose-limiting toxicity of the drug. (recallguide.org)

Pathologic complete response rates were significantly increased in the pembrolizumab group in the intention-to-treat population, with the addition of pembrolizumab being associated with an increase to 64.8%, compared with 51.2% in the control arm (placebo plus paclitaxel and once weekly or every-3-week carboplatin, followed by doxorubicin or epirubicin plus cyclophosphamide). (ascopost.com)

However, nine of the first 17 patients developed grade 3 or higher neutropenia, and four developed grade 3 or higher thrombocytopenia while on weekly panitumumab, nab-paclitaxel, and carboplatin. (medpagetoday.com)
The aim of this study is to investigate the feasibility and determine the pharmacokinetics of low-dose paclitaxel in cancer patients with severe hepatic dysfunction. (ucy.ac.cy)
A dose-finding study of epirubicin in combination with paclitaxel in the treatment of advanced breast cancer. (unimore.it)

For the phase 1 study, researchers enrolled 40 patients with advanced solid tumors. (cancertherapyadvisor.com)
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma [published online ahead of print February 21, 2016]. (cancertherapyadvisor.com)
The dual primary end points were progression-free survival (PFS) and overall survival (OS) in patients whose tumors expressed PD-L1 (CPS ≥1 and CPS ≥10) and in all participants (intention-to-treat population). (cancernetwork.com)
Notably, approximately 38% of patients enrolled in KEYNOTE-355 had tumors expressing PD-L1 at CPS ≥10. (cancernetwork.com)
The secondary end points included pCR rate using alternative definitions of no invasive or noninvasive residual cancer in breast or nodes at the time of definitive surgery, OS, EFS in patients whose tumors express PD-L1 (CPS ≥1), safety, and patient-reported outcomes. (cancernetwork.com)
In a retrospective survey, including 9144 patients, mostly with solid tumors in advanced stages, the probability of developing CHF increased with increasing cumulative doses of Epirubicin Hydrochloride Injection (Figure 5). (recallguide.org)

Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
Researchers also conducted a dose expansion at the maximum tolerated dose of panobinostat in the 20 patients with sarcoma. (cancertherapyadvisor.com)
The investigators collected tumor tissue during the study, both before and after the first dose of panitumumab, to identify biomarkers that could predict pCR. (medpagetoday.com)
Level C produced the best OTU results, owing to lower side effects and better quality of life for the patients who received the lower dose. (medscape.com)
A dose-finding study of ifosfamide by three-day continuous infusion in pretreated, advanced breast cancer patients. (unimore.it)
Patient 6 received a 1,200-mg tion from the European Medicines surveillance network, TropNetEurope, loading dose of quinine before transfer Agency (www.emea.europa.eu/pdfs/ and the Advisory Committee on Malar- to one of the study hospitals (Table). (cdc.gov)

In summary, UFT/leucovorin/etoposide is effective and moderately toxic in patients with advanced gastric cancer. (cancernetwork.com)
Forty-six patients with locally advanced or metastatic gastric cancer received a median of 3 courses each. (cancernetwork.com)
Approximately one-third of patients with gastric cancer undergoes an avoidable lymph node dissection. (frontiersin.org)
Untreated metastatic diffuse gastric adenocarcinoma (DGAC): Randomized phase III study of S-1 and cisplatin vs. 5-FU and cisplatin (the DIGEST trial). (springermedizin.at)
Gastric cancer treatment depends on tumor type, stage, and general health of the patient. (medscape.com)
Patients with recurrence mainly present with distant metastasis, but localized recurrence is seen in 20%-40% of cases and involves the "gastric bed," the lymph nodes and/or the anastomosis, or the duodenal stump. (medscape.com)
Unfortunately, most patients in clinical practice present with advanced or metastatic gastric cancer. (medscape.com)
HER2 protein is overexpressed in approximately 22% of patients with gastric cancer. (medscape.com)
Tailoring therapy based on different characteristics for patients with stage II gastric cancer may produce better outcomes. (springeropen.com)
2009 ). The GLOBOCAN database from 1993 to 2001 showed that 933,293 patients were diagnosed with and 699,803 patients died of gastric cancer yearly (Kamangar et al. (springeropen.com)
2010 ). In the study, more than 40 % of patients had stage I gastric cancer in either the D1 or D2 group. (springeropen.com)
Patients with stage II gastric cancer accounted only for 24 and 23 %, and patients with stage III for 22 and 22 % in the D1 and D2 groups, respectively [staging according to American Joint Committee on Cancer (AJCC), 5th edition] (Fleming et al. (springeropen.com)
Patients with personal or family history of diffuse gastric cancer and/or lobular breast cancer in multiple family members, especially if they were diagnosed before age 50, should be referred for genetic counseling and testing. (msdmanuals.com)

Subsequently, lapatinib, an orally bioavailable small molecule dual HER2- and EGFR/HER1-specific tyrosine kinase inhibitor, received Food and Drug Administration (FDA) approval in combination with capecitabine for patients with advanced HER2+ breast cancer. (carcinogenesis.com)
Multicenter phase 2: Capecitabine (CAP) + oxaliplatin (OX) + bevacizumab (BEV) + trastuzumab (TRAS) for patients (pts) with metastatic esophagogastric cancer (MEGCA). (springermedizin.at)
Hall and his team had previously conducted a phase 2 trial in a similar population of older, frail patients with advanced gastroesophageal cancer and found that the combination of oxaliplatin ( Eloxatin , Sanofi-Aventis) and capecitabine ( Xeloda , Hoffman-LaRoche) was more effective than capecitabine alone. (medscape.com)
Patients in level A received oxaliplatin 130 mg/m 2 once every 21 days and capecitabine 625 mg/m 2 twice a day given continuously. (medscape.com)
The goal of the study was to find the optimum dosage of capecitabine and oxaliplatin for use in older or frail patients and to determine the optimal clinical benefit, tolerability, quality of life, and patient satisfaction. (medscape.com)

The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)
Consequently, endocrine therapy, including tamoxifen or aromatase inhibitors (AIs), has become an effective treatment for these patients. (spandidos-publications.com)
More recently, postmenopausal patients have also had the option of receiving AIs as an alternative to tamoxifen, or following tamoxifen treatment ( 10 ). (spandidos-publications.com)

Select patients for therapy based on an FDA-approved companion diagnostic for a trastuzumab product [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)
With the addition of trastuzumab, a monoclonal antibody targeting the human epidermal growth factor receptor-2 (HER2), improvements in overall survival have been observed among patients with advanced HER2-positive disease. (carcinogenesis.com)
Then, pertuzumab in 2012 and ado-trastuzumab emtansine in 2013 were approved in the US and elsewhere based on evidence showing an improvement in survival outcomes in patients with mostly trastuzumab naïve or trastuzumab-exposed metastatic disease. (carcinogenesis.com)
Trastuzumab will also be given to all patients after surgery. (stanford.edu)
Comparative real-world outcomes for patients with HER2-positive (HER2+) breast cancer receiving adjuvant trastuzumab outside of clinical trials are lacking. (jnccn.org)

Similarly to other anthracyclines, epirubicin acts by intercalating DNA strands. (wikipedia.org)

Background: Although maintenance bacillus Calmette-Guérin (BCG) is the recommended treatment in high-risk non-muscle-invasive bladder cancer (NMIBC), its efficacy in older patients is controversial. (eur.nl)
Objective: To determine the effect of age on prognosis and treatment outcome in patients with stage Ta T1 NMIBC treated with maintenance BCG. (eur.nl)
Design, setting, and participants: A total of 957 patients with intermediate- or high-risk Ta T1 (without carcinoma in situ) NMIBC were randomized in European Organization for Research and Treatment of Cancer (EORTC) trial 30911 comparing six weekly instillations of epirubicin, BCG, and BCG plus isoniazid followed by three weekly maintenance instillations over 3 yr. (eur.nl)
Evaluate left ventricular function in all patients prior to and during treatment with HERZUMA. (rxlist.com)
Patients with FEC100 treatment of the study were relapse-free and an overall survival rate at 5 years higher as in FEC 50 treatment. (wikipedia.org)
We initiated treatment of the patient with moxifloxacin, minocycline, and amikacin 1 day after the athroscopy and the patient's fever subsided within 72 hours. (cdc.gov)
Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma. (cancertherapyadvisor.com)
Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma who are refractory to anthracycline-based therapy, a study published in the journal Annals of Oncology has shown. (cancertherapyadvisor.com)
Treatment options are limited for patients with sarcoma. (cancertherapyadvisor.com)
Panobinostat and epirubicin treatment…may reverse anthracycline resistance," the authors wrote. (cancertherapyadvisor.com)
The study also demonstrated that increased mononucleocyte histone acetylation in the peripheral blood and reduced neutrophil count on day 5 correlated with treatment benefit, suggesting a role as predictive biomarkers. (cancertherapyadvisor.com)
Cancer patients undergoing treatment frequently develop diarrhea and it is fair to assume this is linked to increased intestinal permeability. (naturalmedicinejournal.com)
If confirmed by further study, genotyping for CYP19A1 rs1008805 polymorphism may provide predictive information to improve the selection of endocrine treatment. (spandidos-publications.com)
Conclusion: In this randomised trial, no differences in the efficacy study end points were observed between the two treatment arms. (figshare.com)
Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. (medscape.com)
In this retrospective study, 15 patients who received EPI-TMZ for LMS, including 6 as a first-line treatment, 7 as a second- or third-line treatment, and 2 as a fourth-line treatment, were included. (medjournal360.com)
Efficacy and Safety of Epirubicin Combined with Temozolomide for Treatment of Advanced Leiomyosarcoma. (medjournal360.com)
The purpose of this study is to learn the effects of treatment with an investigational drug, CPX-351 in patients with secondary myeloid neoplasms (SMNs). (sparkcures.com)
See Section 4.2.5 or Appendix II (of protocol) for concomitant therapy restrictions for patients during treatment. (sparkcures.com)
Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
Patients should be carefully monitored during treatment for possible clinical complications due to myelosuppression. (recallguide.org)
These effects do not usually predict subsequent development of delayed cardiotoxicity, are rarely of clinical importance, and are generally not considered an indication for the suspension of epirubicin treatment. (recallguide.org)
If it occurs, delayed cardiotoxicity usually develops late in the course of therapy with Epirubicin Hydrochloride Injection or within 2 to 3 months after completion of treatment, but later events (several months to years after treatment termination) have been reported. (recallguide.org)
Thrombocytopenia often makes the introduction of systemic treatment difficult in patients with cirrhosis and hepatocellular carcinoma (HCC). (hindawi.com)
Therefore, there have been minimal differences in treatment strategy between patients with or without severe thrombocytopenia. (hindawi.com)
The objective of the present study was to and on-treatment questionnaire. (who.int)
Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
because of the rapid improvement af- a water-soluble artemisinin derivate Four patients were Norwegian tour- ter artesunate treatment. (cdc.gov)
ia Prevention in UK Travelers advocate None of the patients needed exchange pdf) and may be obtained from IDIS artesunate as the fi rst-line treatment for transfusions. (cdc.gov)

The actual mean survival time calculated on the basis of the data gained from 64 patients was 7.0 months (range 2-22). (nih.gov)
The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
After a mean follow up of 27 months elapse-free survival of patients who received EC 120 was significantly longer than that of patients who received EC 90. (wikipedia.org)
The median survival rates markedly better than those achieved with epirubicin monotherapy. (wikipedia.org)
Median overall survival for these patients was 8.3 months. (cancertherapyadvisor.com)
With the introduction of anthracycline-based regimens, 5-year survival rates have significantly improved in patients with early-stage breast cancer. (carcinogenesis.com)
A preliminary look at event-free survival was performed in the current study (at one-third of the planned events), with fewer distant recurrences seen in the pembrolizumab arm. (ascopost.com)
But looking at outcomes for patients with and without pCR, no significant difference was seen among the 37 evaluable patients for either disease-free survival (HR 0.66, 95% CI 0.18-2.40, P =0.53) or overall survival (HR 0.69, 95% CI 0.14-3.32, P =0.64) at a median follow-up of 19.3 months. (medpagetoday.com)
Sorafenib has shown survival benefit in patients with advanced HCC patients [ 1 , 2 ]. (hindawi.com)
Long-term survival is poor except for patients with local disease. (msdmanuals.com)

The response rate was 50% in patients with an Eastern Cooperative Oncology Group performance status of 0 to 1. (cancernetwork.com)
CancerTherapyAdvisor.com is a free online resource that offers oncology healthcare professionals a comprehensive knowledge base of practical oncology information and clinical tools to assist in making the right decisions for their patients. (cancertherapyadvisor.com)
He was discussing the results at a press briefing ahead of the annual meeting of the American Society of Clinical Oncology, where the study will be presented. (medscape.com)
Patients must have a performance status corresponding to an Eastern Cooperative Oncology Group (ECOG) score of 0, 1 or 2. (sparkcures.com)

A pharmacologically guided phase I study of carboplatin in combination with methotrexate (30 mg/m2) and vinblastine (4 mg/m2) was conducted in ten patients by increment of the area under the plasma concentration versus time curve (AUC). (shengsci.com)

The aim of this retrospective multicentric study was to compare the tumour response rates of Balloon-occluded Transarterial Chemoembolisation (B-TACE) to non-B-TACE using propensity score matching (PSM) in patients with hepatocellular carcinoma and to investigate the clinical benefit, such as lower rates of TACE re-intervention achieved using B-TACE. (springer.com)
Level 3, retrospective study. (springer.com)

The latest, 8th edition of the TNM Classification of Malignant Tumours ( 8 ) is most frequently used to stage patients. (frontiersin.org)

Epirubicin is also capable of generating cytotoxic free radicals, which are very reactive against DNA, cell membranes and mitochondria. (wikipedia.org)
Epirubicin Hydrochloride Injection should be administered only under the supervision of qualified physicians experienced in the use of cytotoxic therapy. (recallguide.org)

In conclusion, the homozygous minor allele (GG) of CYP19A1 rs1008805 was identified to be significantly associated with an inferior clinical outcome of hormone therapy in postmenopausal hormone receptor‑positive patients with early breast cancer. (spandidos-publications.com)
Median patient age was 57, and 72% were postmenopausal. (medpagetoday.com)

Because inhibition of histone deacetylase appears to improve the efficacy of topoisomerase 2 inhibitors, researchers sought to evaluate panobinostat combined with epirubicin in patients with refractory sarcoma. (cancertherapyadvisor.com)

Forty-six patients received a median of five courses. (cancernetwork.com)
In this younger population (median age of 49 years), effects on fertility will require further study. (ascopost.com)
All 194 patients underwent radical operation plus D2 dissection, and were followed a median time of 23.3 (range 0.4-80.2) months. (springeropen.com)
Median patient age was 67.7 (range 33.9-97.5) years. (springeropen.com)

Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
Patients in level B received 80% of doses given to patients in level A. Patients in level C received 60% of the level-A doses. (medscape.com)

Large-scale meta-genome-wide association study reveals common genetic factors linked to radiation-induced acute toxicities across cancer types. (icr.ac.uk)

Of the 20 patients with refractory sarcoma, 1 achieved a partial response and 11 had stable disease. (cancertherapyadvisor.com)

Researchers found that 4 of the 37 evaluable patients achieved a response, all of which were after progression on prior topoisomerase 2 inhibitors, such as doxorubicin and epirubicin. (cancertherapyadvisor.com)
Among the 17 evaluable patients with triple-negative IBC in the single-arm phase II trial, 47% achieved pCR following surgery (95% CI 23%-72%), reported Naoto Ueno, MD, PhD, of MD Anderson Cancer Center in Houston, and colleagues. (medpagetoday.com)
Overall, pCR was achieved in 30% of evaluable patients (11 of 37, 95% CI, 16%-47%), which was the primary endpoint of the study. (medpagetoday.com)

But chemo-therapy and radiation therapy were not taken and the patient remained in a good condition throughout the 9-year follow-up period. (scirp.org)
This may also lead to more patients being eligible for second-line therapies, as they will be in better clinical condition after finishing their first line of therapy. (medscape.com)
Total and differential WBC, red blood cell (RBC), and platelet counts should be assessed before and during each cycle of therapy with Epirubicin Hydrochloride Injection. (recallguide.org)
Since cirrhotic patients with severe thrombocytopenia are at greater risk for bleeding, treatments against HCC such as liver transplantation, resection, local ablation therapy, and transarterial chemoembolization (TACE) can be performed following a platelet transfusion in those patients. (hindawi.com)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
[ 3-5 ] Despite difficulties in empiric therapy selection, it is well recognized that patients with severe SSTIs require source control via surgical debridement. (medscape.com)

Phase II study of 4'-epi-doxorubicin in patients with untreated, extensive small cell lung cancer. (nih.gov)
It can be used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. (wikipedia.org)
Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
Doctors prescribe epirubicin alongside other medications to treat breast cancer in people who have already had surgery to remove the tumor. (medicalnewstoday.com)
Valrubicin treats bladder cancer in patients who are not eligible for surgery right away. (medicalnewstoday.com)
Idarubicin can treat AML in adults, and researchers are studying its use for other types of cancer. (medicalnewstoday.com)
Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette smoking, with patients often presenting with metastatic disease at the time of diagnosis. (ersjournals.com)
Small cell lung cancer (SCLC) is an aggressive malignant disease, with the majority of patients presenting with distant metastasis at diagnosis. (ersjournals.com)
The International Association for the Study of Lung Cancer defines limited-stage SCLC (LS-SCLC) as: "disease restricted to one hemithorax with regional lymph node metastases, including hilar, ipsilateral and contralateral mediastinal, and ipsilateral and contralateral supraclavicular nodes and should also include patients with ipsilateral pleural effusion independent of whether cytology is positive or negative" 2 . (ersjournals.com)
The FDA has accepted 2 new supplemental biologics license applications (sBLAs) for pembrolizumab (Keytruda) to treat certain patients with triple-negative breast cancer (TNBC), according to Merck, the developer of the agent. (cancernetwork.com)
These acceptances mark the first US applications for [pembrolizumab] in breast cancer, and we look forward to working closely with the FDA to bring these new options to patients as quickly as possible. (cancernetwork.com)
It is now well-established that cancer becomes more aggressive in patients with lowered oxygen. (canceractive.com)
6 In previously reported pembrolizumab studies performed in breast cancer, enrichment of preexisting immunity was required, and benefit is increased with higher combined positive PD-L1 scores in the advanced triple-negative breast cancer population. (ascopost.com)
During the study period, 14 patients had their cancer return, with distant recurrence in 13 patients. (medpagetoday.com)
METHODS: Two hundred and sixty-three patients with invasive breast cancer who received NAC followed by mastectomy or breast conserving surgery (BCS) were enrolled. (bvsalud.org)
To establish penile cancer (PeCa) cell lines for the study of molecular mechanisms of carcinogenesis and testing therapeutic reagents. (oncotarget.com)
The average age of patients at the time of diagnosis of advanced, inoperable gastroesophageal cancer is 75 years, and many are frail," Hall told reporters. (medscape.com)
Most use reduced chemo schedules to treat frail and/or elderly gastroesophageal cancer patients, but without a good evidence base to guide them," he said. (medscape.com)
The GO2 study was a phase 3 trial that included 514 patients aged 51 to 96 years who had advanced gastroesophageal cancer and were residing in the United Kingdom. (medscape.com)
13 patients of 17 patients who to be appeared in complete response were triple negative for breast cancer. (kjco.org)
Generally, tumor size and axillary lymph node metastasis status are the most important prognostic factors for breast cancer patients. (kjco.org)
The activity of glufosfamide (β-D-glucopyranosyl-N,N′ -di-(2-chloroethyl)-phosphoric acid diamide) against pancreatic cancer was investigated in a multicentre, phase II clinical study. (ucy.ac.cy)
A pharmacologically guided phase I study of carboplatin in combination with methotrexate and vinblastine in advanced urothelial cancer. (shengsci.com)
Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma. (shengsci.com)
ABSTRACT Limited research has been devoted to quality of life (QOL) of cancer patients in develop- ing countries. (who.int)
Further improvement of cancer care infrastructure and public education is still needed before reliable QOL studies can be performed. (who.int)
Afin d'estimer la faisabilité d'une évaluation de la qualité de vie dans une cohorte de patients cancéreux tunisiens, nous avons présenté le questionnaire QLQ-C30 de l'EORTC à 23 femmes traitées par chimiothérapie adjuvante en ambulatoire pour un cancer du sein à un stade précoce, au début du traitement et pendant le troisième cycle de chimiothérapie. (who.int)
Il est nécessaire d'améliorer encore l'infrastructure de soins et la sensibilisation du public en matière de cancer si l'on veut réaliser des études fiables sur la qualité de vie des cancéreux. (who.int)
QOL was evaluated using the Arabic issues for cancer patients in these areas. (who.int)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

A new trial with UFT/leucovorin/epirubicin is ongoing. (cancernetwork.com)

Multidisciplinary evaluation plays a crucial role in the management of these patients. (medscape.com)
And, there is a report that NC enabled sentinel lymph node biopsy for patients who require axillary dissection during the initial evaluation [ 3 - 5 ]. (kjco.org)
abstract： PURPOSE:M30 and M65 ELISAs are proposed as surrogate biomarkers of tumour cell death in patients and are being applied increasingly in the pharmacodynamic (PD) evaluation of anticancer drugs during clinical trials. (shengsci.com)
However, a wide range of methodological and practical obstacles to routine QOL evaluation were identified through this study. (who.int)

Previous studies had suggested a synergism between cisplatin and etoposide, and some authors had reported interesting response rates with either of the two combinations: etoposide/cisplatin (EP)[4] or etoposide/doxorubicin (Adriamycin)/cisplatin (EAP). (cancernetwork.com)

Patients in level C experienced fewer side effects and achieved better OTU outcomes than those in level A or B. This was the case even for patients who were younger and less frail. (medscape.com)

These sampling methods are internal and were created specifically for this research study. (cdc.gov)

Parsaclisib, a PI3Kδ inhibitor, in relapsed and refractory follicular lymphoma (CITADEL-203): a phase 2 study. (icr.ac.uk)
BACKGROUND: Parsaclisib, a potent and highly selective PI3Kδ inhibitor, has shown clinical benefit in patients with relapsed or refractory (R/R) B-cell malignancies. (icr.ac.uk)

Epirubicin then stabilizes the topoisomerase II-DNA complex, resulting in irreversible DNA strand breakage, leading to cell death. (wikipedia.org)

Patients were eligible to be enrolled in the trial if they had a disease-free interval of at least 6 months or were de novo metastatic. (cancernetwork.com)
Stanford is currently not accepting patients for this trial. (stanford.edu)
CATALYST - A randomised phase II proof of principle multi-arm multi-stage trial designed to guide the selection of interventions for phase III trials in hospitalised patients with COVID-19 infection. (birmingham.ac.uk)
This trial is the largest so far to be conducted in this subgroup of patients, he said. (medscape.com)
This trial is currently open and accepting patients. (sparkcures.com)
The following criteria is a partial list of reasons why patients may be eligible to participate in this clinical trial. (sparkcures.com)

The relationships between HER dimer expression and RFS and OS were investigated, and multivariate regression analysis identified factors influencing patient prognosis. (ed.ac.uk)

Epirubicin combined with temozolomide (EPI-TMZ) is effective in patients with advanced leiomyosarcoma (LMS) and has tolerable adverse effects, according to a study. (medjournal360.com)
We assessed the acceptability of the immediate and long-term adverse effects questionnaire by estimating the rate of miss- which significantly affect patients' QOL. (who.int)

The latter procedure, along with peritoneal lavage is recommended for stage IB-III patients before surgical resection ( 9 ). (frontiersin.org)

Evidence from preclinical and clinical studies indicates that epidermal growth factor receptor (EGFR) might be a promising therapeutic target for IBC," the team noted. (medpagetoday.com)

Patients underwent baseline angiography of the celiac trunk, superior mesenteric artery, hepatic artery, and splenic artery using a peripheral arterial approach. (hindawi.com)

Participants received panobinostat 20 to 60 mg orally on days 1, 3, and 5, followed by epirubicin 75 mg/m 2 intravenously on day 5 in 3-week cycles. (cancertherapyadvisor.com)

Grades 3 to 4 toxicities appeared as follow: 17% of patients had diarrhea, 11% had nausea/vomiting, and 13% of patients had anemia. (cancernetwork.com)

Diseases8

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes1

Information Science1

Health Care4

Chemotherapy68

Docetaxel10

Fluorouracil8

Ellence2

Ovarian Cancer3

Single agent epirubicin1

Regimen3

Cisplatin and epirubicin1

Toxicity9

Doxorubicin or epirubicin1

Paclitaxel3

Tumors6

Dose6

Gastric13

Capecitabine5

Tamoxifen3

Trastuzumab5

Anthracyclines1

Treatment30

Survival10

ONCOLOGY4

Versus1

Retrospective2

Tumours1

Cytotoxic2

Postmenopausal2

Efficacy1

Median4

Doses2

Acute toxicities1

Sarcoma1

Evaluable3

Therapy6

Cancer30

Leucovorin1

Evaluation4

Etoposide1

Fewer side-effects1

METHODS1

Refractory2

Topoisomerase1

Trial6

Prognosis1

Adverse effects2

Surgical resection1

Therapeutic1

Baseline1

Orally on days1

Toxicities1