Patients reduce allogeneic transfusion. Medical search. Frequent questions

To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Liver transplantation has emerged as an increasingly successful treatment for patients with end-stage liver disease (ESLD). (medscape.com)
Historically, significant blood loss at the time of liver transplantation has been treated with large allogeneic and autologous (cell saver) transfusions of packed red blood cells (PRBCs), fresh frozen plasma (FFP), platelets, and cryoprecipitate. (medscape.com)
Because of many transfusion-related complications, especially those from large-volume transfusions, alternative therapies and approaches to transfusion are being investigated in transplantation and other surgical fields. (medscape.com)
Specific advances, including autologous transfusion with cell saver-washed erythrocytes, venovenous bypass, and argon-beam coagulation, have contributed to liver transplantation success. (medscape.com)
As of 2015, there is some evidence that granulocyte transfusions may help to prevent bacteremia and fungemia in adults who have neutropenia caused by chemotherapy or hematopoietic stem cell transplantation. (wikipedia.org)
For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
Prior to the invention of CAR, cell therapies were largely limited to allogeneic hematological transfusion and transplantation. (scienceboard.net)
OBJECTIVE: The effects of intraoperative blood salvage (IBS) on time to tumor recurrence, disease-free survival and overall survival in hepatocellular carcinoma (HCC) patients undergoing liver transplantation were assessed to evaluate the safety of IBS. (bvsalud.org)
However, the safety of IBS during liver transplantation for patients with HCC is questioned due to fear of disseminating malignant cells. (bvsalud.org)
CONCLUSIONS: Based on available observational data, use of IBS during liver transplantation in patients with HCC does not result in impaired disease-free survival, increased HCC recurrence or impaired overall survival. (bvsalud.org)
Therefore, use of IBS during liver transplantation for HCC patients is a safe procedure. (bvsalud.org)
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. (sagepub.com)
Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. (sagepub.com)
Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
These criteria plus the absence of extrahepatic and major vessel involvement satisfy the Milan criteria, used to assess suitability of liver transplantation for patients who have cirrhosis and hepatocellular carcinoma. (msdmanuals.com)
For patients with liver metastases, transplantation is indicated only for neuroendocrine tumors without extrahepatic growth after removal of the primary tumor. (msdmanuals.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)

This study is a randomised controlled trial of red cell rejuvenation for the attenuation of transfusion associated organ injury in cardiac surgery. (nhsbt.nhs.uk)
To determine whether the rejuvenation of stored allogeneic red blood cells prior to transfusion will reduce postoperative organ injury in cardiac surgery patients at risk of large volume blood transfusion. (nhsbt.nhs.uk)
Primary hypothesis: Post-operative organ injury and inflammation will be reduced if patients undergoing cardiac surgery who are at risk of large volume blood transfusion (defined as the administration of ≥4 units of red cells) receive rejuvenated washed cells as compared to standard care (unwashed aged stored cells). (nhsbt.nhs.uk)
Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. (bloodless.com.br)
Therapeutic options to minimize allogeneic blood transfusions and their adverse effects in cardiac surgery: a systematic review. (bloodless.com.br)
Restrictive red blood cell transfusion strategies remain controversial in patients undergoing cardiac surgery. (biomedcentral.com)
We performed a meta-analysis to assess the prognostic benefits of restrictive red blood cell transfusion strategies in patients undergoing cardiac surgery. (biomedcentral.com)
We identified randomized clinical trials through the 9th of December 2017 that investigated a restrictive red blood cell transfusion strategy versus a liberal transfusion strategy in patients undergoing cardiac surgery. (biomedcentral.com)
Whether the restrictive approach to preoperative RBC transfusion in cardiac surgery safely achieves outcomes similar to those achieved by means of more liberal approaches remains unclear. (biomedcentral.com)
Recent studies have demonstrated that a restrictive strategy for RBC transfusion is not inferior to a liberal strategy with respect to death and other outcomes in patients undergoing cardiac surgery [ 9 , 10 ]. (biomedcentral.com)
The aim of this meta-analysis is to assess the effects of restrictive compared to liberal RBC transfusion on the prognoses of adult patients undergoing cardiac surgery. (biomedcentral.com)
We report on a case in which blood collected from a patient with lung cancer was mistakenly administered to a patient undergoing cardiac surgery who should have received his own collected blood. (bvsalud.org)
The purpose of this prospective non-randomised study was to determine the impact of intraoperative cell salvage on postoperative allogeneic blood products transfusion in infant patients undergoing cardiac surgery with cardiopulmonary bypass. (doctime.es)
Conclusion: Intraoperative cell salvage, employed as an adjuvant technique to the residual volume salvage in infants undergoing first time cardiac surgery with cardiopulmonary bypass, was a safe and effective method to reduce postoperative allogeneic blood transfusion. (doctime.es)
Autotransfusion lowers the transfusion rates during and after Cardiac Surgery. (livanova.com)
The rate of allogeneic red blood cell transfusions in non-cardiac surgery settings has been found to be between 21% and 70%, with the majority of authors reporting figures in the middle of the range. (livanova.com)
Blood transfusions in cardiac surgery: indications, risks, and conservation strategies. (livanova.com)
Intraoperative cell salvage is associated with reduced postoperative blood loss and transfusionrequirements in cardiac surgery: a cohort study. (livanova.com)
Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study. (livanova.com)
The use of both tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) is well described in cardiac surgery, and their use has been shown to reduce postoperative bleeding in meta-analyses. (openanesthesia.org)

Despite using intraoperative cell salvage (IOCS) can reduce ABT r. (researchgate.net)
Background: For a long time intraoperative cell salvage was considered not to be applicable in paediatric patients due to technical limitations. (doctime.es)
The second cohort consisted of patients operated on from August 2005 to December 2006, with additional use of intraoperative cell salvage. (doctime.es)
Results: Additional intraoperative cell salvage significantly enhanced the amount of cell saving product available for transfusion (183+/-56ml vs 152+/-57ml, p=0.003) and significantly more patients in this group received the cell saving product postoperatively. (doctime.es)

Pre, intra and post-operative anemia control, which may negatively affect patient recovery and quality of life. (com.mk)
To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
Taking iron by mouth during pregnancy reduces the risk of anemia caused by too little iron in the body. (webmd.com)
High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. (bloodless.com.br)
Is it the patient or the physician who cannot tolerate anemia? (bloodless.com.br)
Long-lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient. (bloodless.com.br)
Red blood cell (RBC) transfusions can be lifesaving in patients with severe anemia and the purpose of perioperative RBC transfusion is to improve oxygen delivery in patients with anemia [ 4 ]. (biomedcentral.com)
As collection of autologous whole blood caused overt iron loss and anemia before surgery and intraoperative transfusion of whole blood was not able to prevent the occurrence of persistent iron deficiency after surgery, IV iron therapy was found to have potential benefits for iron homeostasis and subsequent erythropoiesis in healthy patients early after bimaxillary orthognathic surgery. (researchsquare.com)
Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic transfusions. (karger.com)
Anemia in pregnancy and the puerperium should be treated according to a staged regimen, administering either iron alone or in combination with an off-label use of human recombinant erythropoietin in selected patients. (karger.com)
The concept comprises early screening and treatment of anemia and iron deficiency, a transfusion and coagulation algorithm during delivery, as well as cell salvage. (karger.com)
OBJECTIVE: To evaluate the effects of recombinant human erythropoietin (r-HuEPO) in attempting to prevent anemia in acutely burned patients. (weborto.net)
CONCLUSION: In our work the administration of r-HuEPO in acutely burned patients did not prevent the development of postburn anemia or decrease transfusion requirements. (weborto.net)
Anemia associated with Chronic Renal Failure, including patients on dialysis (ESRD) and patients not on dialysis. (lifesaverpharma.com)
Anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitantly administered chemotherapy. (lifesaverpharma.com)
Anemia related to therapy with zidovudine in HIV-infected patients. (lifesaverpharma.com)
Treatment of severe anemia associated with chronic renal failure, anemia in Zidovudine treated HIV infected patients, anemia in cancer patients on chemotherapy.To increase the yield of autologous blood from patients in a predonation programme initiated to avoid the use of homologous blood. (alldrugs.co.il)
Patient activity may be limited secondary to severe anemia. (medscape.com)
before performing an extensive operation with an expected blood loss of 900-1800 ml in adult patients without anemia or with mild to moderate anemia (hemoglobin level 100-130 g / l) to reduce the need for allogeneic blood transfusions and facilitate the restoration of erythropoiesis. (newpharmacy.org)
A 2014 study in pediatric ICU patients demonstrated that nHgb monitoring and invasive Hgb (iHgb) monitoring in children with normal Hgb and mild anemia were positively correlated. (jposna.org)
4. Sometimes (in case of low-risk MDS anemia), chelation removes the toxic effect of iron on erythropoiesis and transforms transfusion dependent anemia in transfusion-independent. (haema-journal.gr)
Chronic transfusion allows to avoid complications in patients suffering from sickle cell anemia, to survive in patients with beta thalassemia major, or with Diamond-Blakfan anemia or with a form of CDA (Congenital Dyserythropoietic Anemia), or even suffering from anemia secondary to MDS, myelofibrosis or aplastic anemia. (haema-journal.gr)
The healthcare system can promote tailored strategies to reduce barriers and increase TCD screening and hydroxyurea use among children with sickle cell anemia. (cdc.gov)

CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Transfusions, however-especially large-volume transfusions-are associated with a range of complications. (medscape.com)
This patient, along with the next 4, died of bleeding complications. (medscape.com)
Increasing focus on patient safety is also expected to promulgate the deployment of patient blood management software in healthcare institutions to reduce complications and medical costs. (factmr.com)
Degenerative lumbar scoliosis (DLS) patients undergoing posterior long-segment spinal fusion surgery often require perioperative blood transfusions, and previous studies have reported that increased complications and additional costs accompany these transfusions. (medscimonit.com)
Bleeding complications should be anticipated and blood loss reduced by interdisciplinary preventive measures and individually tailored care. (karger.com)
Background - Red blood cell (RBC) transfusion is independently associated in a dose-dependent manner with increased intensive care unit stay, total hospital length of stay, and hospital-acquired complications. (edu.au)
Viscoelastic testing that provides rapid, actionable results to help clinicians reduce risks, complications and costs. (haemonetics.com)
To reduce exposure to allogeneic blood transfusions in adult non-iron deficient patients prior to major elective orthopaedic surgery, having a high perceived risk for transfusion complications. (medscape.co.uk)
However chronic transfusion presents risks of serious, sometimes mortal complications. (haema-journal.gr)
Hydroxyurea therapy, which reduces the occurrence of several complications, including severe acute pain episodes and acute chest syndrome. (cdc.gov)

In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
Preemptive IV iron therapy provides noninferior hemoglobin levels on postoperative day (POD) 1 compared to autologous whole blood therapy (AWBT) in healthy patients who had undergone bimaxillary orthognathic surgery. (researchsquare.com)
On POD 2, the hemoglobin level became lower in the iron group, which eventually led to greater requirement of allogeneic blood transfusion compared to the whole blood group. (researchsquare.com)
Secondary outcomes included postoperative hemoglobin, length of stay, allogeneic transfusions, and use of local infiltration analgesia (LIA) and tranexamic acid (TXA). (transfusionevidencelibrary.com)
Studies clearly reporting a comparison of oral and intravenous TXA were selected, and total blood loss (TBL), the decline in hemoglobin (DHB), deep vein thrombosis (DVT), intramuscular venous thrombosis (IVT), the length of hospital stay, and the transfusion rate were evaluated. (biomedcentral.com)
There was no significant difference in terms of total blood loss, the decline in hemoglobin, the length of hospital stay, the incidence of DVT or IVT, or the transfusion rate between the oral and intravenous groups, and five studies reported that oral TXA was associated with a lower cost. (biomedcentral.com)
3) examination includes any one among total blood loss, decline of hemoglobin (DHB), DVT, IVT, length of hospital stay, and transfusion rate. (biomedcentral.com)
Perisurgery: Reduction of allogeneic blood transfusion in surgery patients : Eprex is indicated for the treatment of anemic patients (hemoglobin 9-11 g/dl) scheduled to undergo elective, noncardiac, nonvascular surgery to reduce the need for allogeneic blood transfusions. (alldrugs.co.il)
Later, our total joint arthroplasty colleagues demonstrated that nHgB monitoring was more efficient, less expensive, and preferred by patients compared to invasive hemoglobin (iHgb) monitoring. (jposna.org)
These patients usually are stable enough to complete at least a cursory preparation for major spine surgery, including a detailed history and physical exam, complimented by baseline measures of coagulation and hemoglobin, type and cross for blood, and, if possible, an indication of cardiopulmonary function and appropriate functional testing if indicated. (renalandurologynews.com)

One method for decreasing transfusions is the administration of tranexamic acid (TXA). (medscimonit.com)
Tranexamic acid (TXA) has been demonstrated to reduce blood loss following primary total knee and hip arthroplasty. (biomedcentral.com)
This study aimed to compare the efficacy and safety of oral and intravenous tranexamic acid for primary total knee and hip arthroplasty patients. (biomedcentral.com)

METHODS: Thirty-eight patients having total hip joint replacement surgery were randomised to receive either autologous blood transfusion (control group) or autologous transfusion plus preoperative recombinant human erythropoietin treatment (EPO group). (weborto.net)

We report 2 cases of this disease in allogeneic hematopoietic stem cell transplant patients successfully treated with fumagillin. (cdc.gov)
We report 2 cases of E. bieneusi microsporidiosis in allogeneic hematopoietic stem cell transplant (HSCT) recipients who were treated with fumagillin and experienced thrombocytopenia. (cdc.gov)
Platelet counts and clinical and parasitologic characteristics during fumagillin therapy and a 1-month follow-up of 2 allogeneic hematopoietic stem cell recipients with Enterocytozoon bieneusi microsporidiosis. (cdc.gov)

State-of-the-art autotransfusion technology that helps hospitals avoid unnecessary allogeneic transfusions, while helping to reduce related costs. (haemonetics.com)
Autotransfusion supports clinicians and patients in reducing blood transfusions. (livanova.com)
In orthopedics, autotransfusion is safe, effective and reduces the risk of transmission of infections. (livanova.com)
In transplant surgery, autotransfusion can reduce the need for heterologous blood transfusion and the risk of transmissible diseases. (livanova.com)

Strategies to decrease the use of allogeneic blood transfusion include preoperative autologous blood donation and intraoperative hypotensive anesthesia. (researchsquare.com)
[email protected] BACKGROUND: Recombinant human erythropoietin in combination with preoperative autologous blood donation is an established regime for avoiding allogenic blood transfusions. (weborto.net)
We question whether recombinant human erythropoietin treatment facilitates preoperative autologous blood donation in patients with normal haemoglobin levels. (weborto.net)

The trial design will include an initial feasibility phase of 20 patients to assess whether the intervention can be delivered on time, and to review recruitment rates, protocol compliance rates and withdrawal rates. (nhsbt.nhs.uk)
The number of patients in need of revision surgery due to wound healing disorders was low in both groups (control group: 4/53 vs intervention group: 4/79). (bvsalud.org)
Only one patient in the control group and two patients in the intervention group underwent revision surgery due to hemorrhage. (bvsalud.org)
Designing an intervention to help people with colorectal adenomas reduce their intake of red and processed meat and increase their levels of physical activity: a qualitative study. (nuffieldhealth.com)
Studies show that this intervention comeswith largely underestimated service cost and unacceptably highutilisation variability for matched patients, thus adding billions ofunnecessary dollars to the health-care expenditure each year.Moreover, a large and increasing body of literature points to adose-dependent increase of morbidity and mortality and adverselong-term outcomes associated with transfusion whereas publishedevidence for benefit is extremely limited. (edu.au)
At baseline, data were gathered for 924 patients from 10 intervention and 1040 patients from 11 control hospitals undergoing hip or knee arthroplasty. (transfusionevidencelibrary.com)
After the intervention, data were gathered for 997 patients from the intervention and 1096 patients from the control hospitals. (transfusionevidencelibrary.com)
RESULTS The use of blood salvage (OR 0.08, 95% CI 0.02 to 0.30) and erythropoietin (OR 0.30, 95% CI 0.09 to 0.97) reduced significantly over time, but did not differ between intervention and control hospitals (blood salvage OR 1.74 95% CI 0.27 to 11.39, erythropoietin OR 1.33, 95% CI 0.26 to 6.84). (transfusionevidencelibrary.com)
Transfusions did not differ between the intervention and control hospitals (OR 1.06, 95% CI 0.63 to 1.78). (transfusionevidencelibrary.com)
CONCLUSIONS Blood salvage and erythropoietin use reduced over time, but not differently between intervention and control hospitals. (transfusionevidencelibrary.com)

To decrease these risks, as well as the risk of serious cardiovascular and thromboembolic reactions, use the lowest dose needed to avoid RBC transfusions [see DOSAGE AND ADMINISTRATION ]. (rxlist.com)

The following variables were analysed: peri- and postoperative blood loss, transfusion of homologous blood products and cell salvage product, haematological and coagulation data, measured before, during and after the operation. (doctime.es)
Adverse events are still found in clinical practice related either directly or indirectly to homologous blood transfusion. (livanova.com)

Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
Patients with acute or chronic liver failure do not synthesize normal amounts of clotting factors II (prothrombin), VII, IX, and X. Decreased production of these factors may lead to a coagulopathy, which is typically identified by a prolonged prothrombin time (PT). (medscape.com)
Blood donations across the world have increased substantially in recent years owing to rising demand for blood transfusions while treating several chronic diseases that are expected to rise across the forecast period. (factmr.com)
Enterocytozoon bieneusi , the most common cause of microsporidiosis in humans ( 1 ), causes chronic diarrhea and severe wasting syndrome in immunocompromised patients ( 2 ). (cdc.gov)
Because human beings do not possess effective mechanisms to get rid of iron, chronic transfusion leads to iron overload responsible of lesions in parenchymal organs and or in dysfunctions of endocrine glands. (haema-journal.gr)
Chronic transfusion exceeds loading capacity of iron in macrophages and hepatocytes. (haema-journal.gr)
These patients should be prepared by ensuring that a detailed history and physical exam is performed and all chronic conditions have been maximally optimized prior to surgery. (renalandurologynews.com)

Growing focus on healthcare cost reduction is also expected to drive the demand for patient blood management (PBM). (factmr.com)
The reduction in blood salvage and erythropoietin did not lead to a deterioration in patient-related secondary outcomes. (transfusionevidencelibrary.com)
The benefit of transfusion reduction may be especially advantageous in situations where allogeneic transfusion is unacceptable or undesired (Jehovah's witnesses, transplant candidates, etc. (openanesthesia.org)
Symptomatic anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient's general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy). (medscape.co.uk)

Adverse effects from granulocyte transfusions include fever, chills, respiratory symptoms, transfusion-transmitted infections, and the development of antibodies against human leukocyte antigens, which can interfere with subsequent transfusions. (wikipedia.org)
However, it is unclear whether this has any impact on mortality or major adverse events, and the use of granulocyte transfusions to prevent infections is considered controversial because of the potential for serious side effects. (wikipedia.org)
Thrombocytopenia is the main adverse event of fumagillin therapy, occurring in up to 33% of patients ( 3 ) and raising concerns about fumagillin use in patients with hematologic disorders. (cdc.gov)
Antifibrinolytic agents are commonly used as part of a comprehensive blood management strategy to reduce bleeding, allogeneic blood administration, and transfusion-related adverse events. (openanesthesia.org)

Case report: intraoperative management of extreme hemodilution in a patient with a severed axillary artery. (bloodless.com.br)
BACKGROUND Acute normovolemic hemodilution (ANH) decreases transfusion rates but adds to the complexity of anesthetic management during hepatectomy. (transfusionevidencelibrary.com)

CONCLUSIONS: In patients with normal preoperative haemoglobin levels, recombinant human erythropoietin treatment did not improve haemoglobin levels, or reduce the need for allogenic blood transfusion. (weborto.net)
Allogenic blood transfusion associates the currently decreased risk of infectious disease transmission. (openorthopaedicsjournal.com)
2/60 (3.3%) patients required an allogenic blood transfusion perioperatively. (jposna.org)
Guidelines for an Allogenic Blood Transfusion (ABT) at our institution were developed through consensus between the surgical and anesthesia teams. (jposna.org)

as well as efficiency of the already existing blood supply of the patient undergoing a surgical procedure. (com.mk)
Methods ASD patients enrolled in a prospective, multicenter surgical database who had complete preoperative and surgical data were identified. (umn.edu)
Washed cell salvage in surgical patients. (livanova.com)
Trends in blood utilization in United States cardiac surgical patients. (livanova.com)
Total knee/hip arthroplasty (TKA/THA) is a reliable surgical procedure for patients suffering from moderate to severe degenerative knee or hip joint diseases and osteoarthritis pain, but perioperative bleeding is a major challenge for surgeons. (biomedcentral.com)
Patients in both groups underwent cemented TKA with the same system, surgical technique, and multimodal protocol (MIS approach, plug in the femoral canal, tourniquet removal after wound closure and compressive bandage, analgesic periarticular infiltration with vasoconstrictor, postoperative drain at atmospheric pressure, opened 2 hours after the end of the surgical procedure and removed after 24 hours). (openorthopaedicsjournal.com)
As a conclusion, implementing a TXA-based multimodal protocol produced significant decrease in the transfusion rate, visible blood loss, and cost per patient, thus proving effectiveness and efficiency in the surgical management of TKA. (openorthopaedicsjournal.com)
The risk factors associated with the development of a surgical site infection (SSI) varies according to specific patient factors and clinical characteristics, in addition to the nature of the surgical procedure. (bmj.com)
Improvements in immune-modulating therapy, critical care medicine, and surgical techniques have led to the increased success of organ transplantations, and more patients are now eligible for these procedures. (cdc.gov)

Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review. (bloodless.com.br)
Acheson A, Brookes MJ and Spahn D. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery - Systematic review and meta-analysis. (nuffieldhealth.com)
Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-analysis of randomised clinical trials. (hkjgom.org)

Restrictive and liberal red cell transfusion strategies in adult patients: reconciling clinical data with best practice. (bloodless.com.br)
Severe symptomatic anaemia of renal origin in adult patients with renal impairment not yet undergoing dialysis. (medscape.co.uk)

N = 1,927) demonstrated reduced odds of transfusion after erythropoietin, but higher-quality trials reported smaller odds reductions. (cancernetwork.com)
1.A double-blinded prospective evaluation of recombinant human erythropoietin in acutely burned patients. (weborto.net)
BACKGROUND Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used. (transfusionevidencelibrary.com)
The most common side effects during treatment with erythropoietin are myocardial infarction, stroke, and thromboembolism, increased mortality and/or increased risk of tumor progression or recurrence in patients with cancer, hypertension, seizures, serious allergic reactions etc. (lifesaverpharma.com)
Erythropoietin should be used with caution in those patients with controlled hypertension, ischaemic vascular disease, history of seizures, or suspected allergy to the product. (lifesaverpharma.com)

ESAs are not indicated for patients receiving myelosuppressive chemotherapy when the anticipated outcome is cure [see INDICATIONS AND USAGE]. (rxlist.com)
Active hemorrhage resulting in shock is one of the few evidence-based established indications for transfusion. (medscape.com)
We analyzed the knowledge of general and specialists doctors from the Caja Nacional de Salud, about indications, benefits and risks of blood transfusions and blood derivatives before the implementation of the new blood transfusion application form or blood derivatives of the National Blood Program and the Caja Nacional de Salud. (scienceopen.com)
90.8% of professionals expected to find clinical improvement with transfusion, 99.3% know the transmission of infection risks through these, 92.9% evaluated benefits and risks before commanding the blood transfusion, 66.6% of register in the clinical history the reasons for the indication, however, there is a few knowledge about the therapeutic alternatives before transfuse and the blood transfusion indications are not uniform. (scienceopen.com)
The transfusion-saving strategy has to begin with the training of medical personnel related to indications, the development of a adequate user manual of blood derivatives and stimulants haematinics and folates use protocols in preoperative rescue cases, ferropenic, megaloblastic anemias and the creation hemosurveillance committee in accordance with the policies of the National Blood Program. (scienceopen.com)

For patient education information, see Cirrhosis and Liver Transplant . (medscape.com)
The transplant procedure is similar to a simple blood transfusion and will be done in your hospital room. (ucsfhealth.org)
In 2002, oral fumagillin was established as an effective treatment for E. bieneusi microsporidiosis in HIV-infected and solid organ transplant (SOT) patients ( 3 ). (cdc.gov)
Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. (sagepub.com)
Although this is presumed to be a curative strategy, many patients relapse after transplant, prompting us to examine various ways that we can improve outcomes. (sagepub.com)
The hope is that improvement in these steps will ultimately improve survival and decrease relapse rates for AML patients after transplant. (sagepub.com)
[ 14 ] The first successful allogeneic stem cell transplant from an HLA-identical sibling donor was reported in 1982. (medscape.com)
Both meetings agreed minimum criteria for suitability of live donors and defined the obligations of transplant professionals to treat donors as patients, including appropriate follow-up and treatment for problems caused by the donation. (who.int)
Reduced intensity treatment, also called a mini transplant -- Lower doses of chemotherapy and radiation are given before a transplant. (medlineplus.gov)
Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)

13 g/dL) scheduled to undergo elective, noncardiac, nonvascular surgery to reduce the need for allogeneic blood transfusions. (lifesaverpharma.com)
Treatment should only be given to patients with moderate anaemia (Hb 10g/dL to 13g/dL, no iron deficiency), if blood conserving procedures are insufficient or when scheduled major elective surgery requires a large volume of blood (4 or more units for females, 5 or more units for males). (medscape.co.uk)
A progression in symptoms from neural impingement or pain that is not responsive to maximal nonoperative therapy usually results in the patient presenting for elective major spine surgery. (renalandurologynews.com)

Purpose of review: Evidence-based patient blood management (PBM) is aimed at achieving better patient outcomes by relying on a patient's own blood rather than on donor blood. (edu.au)
As we all know, transfusions extend not only the patient's rehabilitation time but also the length of hospital stay. (biomedcentral.com)

Previous studies have reported the efficacy and safety of intravenous (IV) iron therapy during perioperative period as an alternative and adjunct to allogeneic blood transfusion. (researchsquare.com)
The objective of this meta-analysis was to determine TXA's efficacy in reducing blood loss and blood transfusion in idiopathic scoliosis surgery. (amegroups.org)
Many randomized controlled trials (RCT) and meta-analyses support the efficacy of these agents in reducing blood loss and transfusion. (openanesthesia.org)
This study investigates the safety and efficacy of ferric derisomaltose (FDI) and its effect on blood transfusion requirements in women with severe anaemia secondary to heavy menstrual bleeding (HMB). (hkjgom.org)
Hydroxyurea has proven clinical efficacy for SCA - treatment significantly reduces disease manifestations and prolongs survival. (cdc.gov)

ESAs shortened overall survival and/or increased the risk of tumor progression or recurrence in clinical studies of patients with breast, non-small cell lung, head and neck, lymphoid, and cervical cancers [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)
Introduction: Intra-operative cell salvage (IOCS) can reduce allogeneic blood transfusion requirements in non-tumour related spinal surgery despite its limited use in metastatic spine tumor surgery (MSTS) due to risk of tumour dissemination. (researchgate.net)
Therefore, the clinical situations in which PFC treatment may be beneficial are those that require a short duration of supplemental tissue oxygenation in patients with a high arterial oxygen tension (≥ 400 mmHg): acute tissue ischemia, organ preservation, cardioplegia, cardiopulmonary bypass pump prime, cerebral protection, tumor sensitization, and temporary red blood cell substitution. (asahq.org)
INTRODUCTION: Resection of musculoskeletal tumors and reconstruction with tumor endoprostheses often results in blood loss requiring transfusion of blood products. (bvsalud.org)

to optimize patient care and minimize the demand for blood and blood products. (com.mk)
In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
For example, when receiving some types of chemotherapy, patients must shower thoroughly twice a day to remove the drug that is excreted through the skin - this is done to help prevent or minimize chemotherapy burns. (ucsfhealth.org)

[ 1 ] Increased blood requirements in OLT are associated with a more frequent occurrence of sepsis, longer stays in the intensive care unit, a higher rate of severe cytomegalovirus infection, and higher rates of graft failure and patient mortality. (medscape.com)
Granulocyte transfusion is still used in some cases, such as when a person has severe neutropenia and an infection that is life-threatening or does not respond to antimicrobial treatment. (wikipedia.org)
Our meta-analysis demonstrates that the restrictive red blood cell transfusion strategy was not inferior to the liberal strategy with respect to 30-day mortality, pulmonary morbidity, postoperative infection, cerebrovascular accidents, acute kidney injury, or acute myocardial infarction, and fewer red blood cells were transfused. (biomedcentral.com)
In 2002, several cases of serologically confirmed West Nile virus infection occurred in persons with little or no known exposure to mosquitoes, and epidemiologic evidence suggested transmission of the virus through blood transfusions. (cdc.gov)

However, the iron group did not require allogeneic blood transfusion during or early after surgery, and the whole blood group showed continuously higher incidence of overt iron deficiency compared to the iron group. (researchsquare.com)
Inform patients that their condition is hereditary and that physicians sometimes mistake the disorder for iron deficiency. (medscape.com)

The literature includes cases of OLT performed without transfusion of any blood products and OLT performed safely without additional blood products if blood loss is limited to 1600-3400 mL. (medscape.com)
Allogeneic blood transfusion (ABT) is the mainstay for replenishing blood loss, placing an undue strain on limited blood bank resources and exposing patients to ABT associated risks. (researchgate.net)
Summary: Metastatic spine tumour surgery (MSTS) is associated with significant blood loss, which is presently replenished by allogeneic blood transfusion (ABT). (researchgate.net)
Mean differences (MDs) of blood loss and blood transfusions in TXA-treated group compared to control and/or placebo group were extracted and combined using random-effect meta-analysis model. (amegroups.org)
Patients treated with TXA had a significantly lower blood loss and lower rates of allogeneic blood transfusion than the control group. (amegroups.org)
TXA inhibits plasminogen activation by binding plasmin to fibrin, which leads to clot stabilization and reduces blood loss. (biomedcentral.com)
Blood loss in TKA patients is multifactorial. (openorthopaedicsjournal.com)
Eprex is indicated for patients at high risk for periopertive transfusions with significant, anticipated blood loss. (alldrugs.co.il)

However, this information was gathered on an adult patient population that underwent joint replacement surgery (hip or knee). (jposna.org)

Although the studies performed to date have been low-quality, a 2016 review suggested that granulocyte transfusion may not be effective for treating infections in adults with neutropenia. (wikipedia.org)

Results showed no transfusion requirements in the TXA series (0%), with 23/61 (37.7%) transfusions in the control, with an average cost decrease of 240 euros per patient. (openorthopaedicsjournal.com)
For anemic patients with inefficient erythropoiesis, the use of these inhibitors of the TGFβ pathway could improve Hb levels and decrease transfusion requirements. (haema-journal.gr)

Some patients receive total body irradiation (TBI) in addition to chemotherapy. (ucsfhealth.org)
Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML. (sagepub.com)

The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit. (lifesaverpharma.com)

5 It can contribute to improved clinical outcomes in a cost-effective manner, either as stand-alone or as part of a Patient Blood Management program. (livanova.com)
Our research suggests that compared with intravenous use of TXA, the oral approach has similar clinical outcomes and is less expensive for total joint replacement patients. (biomedcentral.com)

The blood stem cells will be infused through your central venous catheter just like a regular blood transfusion. (ucsfhealth.org)

Consequently, allogeneic blood transfusion was significantly reduced in volume as well as in frequency. (doctime.es)
In patients with burns from 25% to 35%, the reticulocyte counts were statistically significantly higher. (weborto.net)
FDI significantly reduces the requirement for blood transfusions. (hkjgom.org)

as well as identifying where and when different strategies will be combined to produce the best benefit for the patient. (com.mk)
Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. (scienceopen.com)

If the recipient has antibodies against human leukocyte antigens (HLA), proteins found on the surface of white blood cells, the donor's cells need to be tested for compatibility, because antibodies against donor granulocytes can reduce the effectiveness of the transfusion and cause transfusion reactions. (wikipedia.org)
As the risks of allogeneic blood transfusion (ABT)-transmitted viruses were reduced to exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic transfusion reactions (HTRs), and transfusion-associated sepsis (TAS) emerged as the leading causes of ABT-related deaths. (scienceopen.com)
Immunologic reactions were the first obstacle and risk, related to transfusions. (haema-journal.gr)

Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
However, RBC transfusion has been associated with high rates of mortality and morbidity in critically ill patients [ 6 ]. (biomedcentral.com)
About one-third of severely injured trauma patients are coagulopathic on hospital arrival, and the presence of acute traumatic coagulopathy increases patient mortality by more than 4-fold. (openanesthesia.org)
Infectious causes of ABT-related deaths currently account for less than 15% of all transfusion-related mortality, but the possibility remains that a new transfusion-transmitted agent causing a fatal infectious disease may emerge in the future. (scienceopen.com)
Increasing data indicate that hydroxyurea has a substantial effect on reducing mortality in both adults and children-perhaps the most compelling reason for advocating the drug's widespread use. (cdc.gov)

Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
However, it remains unclear whether these differences in outcome are related to the transfusion as an independent risk factor or the transfusion is a marker for a technically more difficult surgery. (medscape.com)
Using cell saver can reduce ABT requirements but it is contraindicated in tumour surgery due to risk of tumour dissemination. (researchgate.net)
To establish whether patients at increased risk of red cell transfusion can be transfused with rejuvenated red cells. (nhsbt.nhs.uk)
Taking iron during pregnancy doesn't seem to reduce the risk for preterm birth. (webmd.com)
In vascular surgery, it reduces the risk of allogeneic blood transfusion, the length of intensive care unit and hospital length stay. (livanova.com)
The primary end point was appropriate management, defined as avoidance of ANH in patients at low risk or use of ANH in patients at high risk for allogeneic red blood cell transfusions. (transfusionevidencelibrary.com)
Among others, this study's failure may be attributed to the wide utilization of animal models that lack prevalent vascular risk factors (e.g., age, hyperlipidemia, diabetes) and/or the use of treatments that act too unspecifically to achieve clinically sustainable improvements in stroke patients. (explorationpub.com)
Screening tests and viro-inactivation techniques have made transfusion safe (actual residual risk almost zero in Switzerland). (haema-journal.gr)
Consultation with a neurologist may assist in therapeutic recommendations in light of the limitation of their use with imminent surgery, as well as to allow an adequate and informed risk benefit discussion with the patient. (renalandurologynews.com)
Any visual deficits should be documented, given the increased risk of postoperative visual loss (follows) in these patients. (renalandurologynews.com)

We sought to evaluate the costs and benefits of preoperative administration of 1 g of intravenous TXA, without maintenance, in DLS patients undergoing long-segment spinal fusion surgery. (medscimonit.com)
METHODS: We retrospectively analyzed data of 132 patients (79 interventions, 53 controls) undergoing surgery by one single experienced surgeon in our tertiary referral center between 2012 and 2021. (bvsalud.org)
p = 0.0005), while the transfusion rate after surgery did not change notably. (bvsalud.org)
Authorization for surgery patients will be for a maximum of 4 weeks. (oklahoma.gov)
Objectives To determine if the use of cell saver reduces overall blood costs in adult spinal deformity (ASD) surgery. (umn.edu)
Patients were stratified into (1) cell saver available during surgery, but no intraoperative autologous infusion (No Infusion group), or (2) cell saver available and received autologous infusion (Infusion group). (umn.edu)
Conclusion Compared to transfusing allogeneic blood, cell saver autologous infusion did not reduce the proportion or the volume of allogeneic transfusion for patients undergoing surgery for adult spinal deformity. (umn.edu)
International Spine Study Group 2017, ' Cell Saver for Adult Spinal Deformity Surgery Reduces Cost ', Spine Deformity , vol. 5, no. 4, pp. 272-276. (umn.edu)
Participants Patients undergoing general abdominal surgery. (bmj.com)
Some patients may be on platelet inhibitors, including aspirin or clopidogrel, and it is unlikely that the surgeon would proceed with surgery while a patient is on these agents. (renalandurologynews.com)
Most patients presenting for spine surgery have underlying pain, usually treated with enteral opioids. (renalandurologynews.com)

Clinical decision support promoting restrictive blood transfusion practices. (bloodless.com.br)
Restrictive blood transfusion practices are associated with improved patient outcomes. (bloodless.com.br)

Use the lowest Epogen dose sufficient to reduce the need for red blood cell (RBC) transfusions [see WARNINGS AND PRECAUTIONS ]. (rxlist.com)

The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
A granulocyte transfusion is a medical procedure in which granulocytes (a type of white blood cell) are infused into a person's blood. (wikipedia.org)
Secondary hypothesis: Rejuvenation will attenuate platelet and monocyte activation, oxidative stress, endothelial dysfunction and tissue hypoxia attributable to allogeneic red cell transfusion. (nhsbt.nhs.uk)
The goal is to support you with red blood cell and platelet transfusion until you are producing cells again. (ucsfhealth.org)
July 20, 2021 -- Cellular reprogramming of ex vivo cells may offer improvements on first-generation adoptive cell therapies, which have experienced limited clinical success due to complex manufacturing, potential patient rejection, and availability of clinical cell types. (scienceboard.net)
The clinical success of anti-CD19 CAR T-cell therapies has not only provided efficacious treatment alternatives for cancer patients but also aided the developmental and regulatory precedent for the translation of cell-based therapies for other disease areas. (scienceboard.net)
Techniques such as cellular reprogramming will allow the exploration of scalable allogeneic cell sources and the optimizable generation of cells for therapeutic development. (scienceboard.net)
This circumvents the need for any intermediary steps and reduces the time required to produce a cell type for therapeutic use. (scienceboard.net)
First-generation ex vivo cell therapies, such as autologous anti-CD19 CAR T cells, demonstrated the clinical value and curative potential of enhancing the therapeutic qualities of immune and other patient-derived cell types. (scienceboard.net)
As a result, developmental trends have shifted toward an allogeneic approach, seeking to replace autologous cell sources with consistent and scalable alternatives, such as iPSCs. (scienceboard.net)
The benefits of an allogeneic "off-the-shelf" cell therapy approach are clear: batch-producing cells derived from an unrelated donor or universal cell source that can be used to treat many patients. (scienceboard.net)
If the cost of cell saver blood was transformed into costs of allogeneic blood, total blood costs for the Infusion group would range from $840 to $5,418. (umn.edu)
Thus, cell saver use yielded a mean cost savings ranging from $330 to $422 (allogeneic blood averted). (umn.edu)
It brings together three decades of experience and improvements in cell salvage procedures, treating more than 0.5 million patients per year. (livanova.com)

The silent risks of blood transfusion. (bloodless.com.br)

There was no difference in the requirement for allogeneic blood transfusions between the groups. (weborto.net)

The baseline haemoglobin was >13 g dL-1 in all but four patients. (weborto.net)

Anatomy5

Organisms4

Diseases23

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes16

Technology, Industry, Agriculture1

Humanities1

Information Science1

Named Groups3

Health Care10

Transplantation24

Cardiac Surgery20

Intraoperative cell salvage4

Anemia23

Complications11

Hemoglobin10

Tranexamic3

Autologous transfusion1

Hematopoietic stem3

Autotransfusion4

Preoperative autologous blood donation3

Intervention10

Avoid RBC transfusions1

Homologous blood2

Chronic7

Reduction4

Adverse4

Hemodilution2

Allogenic4

Surgical9

Systematic3

Adult patients2

Erythropoietin5

Indications5

Transplant12

Elective3

Patient's2

Efficacy5

Tumor4

Minimize3

Infection4

Iron deficiency2

Blood loss8

Underwent1

20161

Decrease2

Chemotherapy2

Hematocrit1

Clinical outcomes2

Stem cells1

Significantly3

Strategies2

Reactions3

Mortality6

Risk11

Surgery11

Restrictive blood2

Sufficient to reduce the need1

Cell14

Risks of blood1

Requirement1

Baseline1