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  • HSCT
  • Thus, cryotherapy during MTX administration does not reduce severe oral mucositis in patients undergoing myeloablative allogeneic HSCT. (nih.gov)
  • This exploratory natural history study involves a prospective review of the medical records of patients actively enrolled in allo-HSCT protocols at the NIH. (clinicaltrials.gov)
  • The study involved patients treated with HSCT in the Hematology-Oncology Department between 1984 and 2007. (frontiersin.org)
  • We, therefore, performed a retrospective analysis of patients with major or bidirectional ABO incompatible HSCT undergoing two different regimens: (i) pretransplant reduction of anti-donor isoagglutinin titer and post-transplant transfusion of donor-type RBC or (ii) removal of RBC from the graft followed by post-transplant transfusion of recipient-type RBC. (haematologica.org)
  • Most of the diseases for which HSCT is a standard treatment are disorders of blood cell lineage. (parentsguidecordblood.org)
  • We retrospectively evaluated early lymphocyte recovery after HSCT among Japanese adults who received MMF prophylaxis. (springer.com)
  • We conclude that among Japanese patients who received MMF prophylaxis, ALC on day 28 after HSCT was effective in predicting overall survival and non-relapse mortality. (springer.com)
  • MINNEAPOLIS & AMSTERDAM, May 22, 2019 - Be The Match BioTherapies ®, an organization offering solutions for companies developing and commercializing cell and gene therapies, and Kiadis Pharma N.V. ("Kiadis") (Euronext Amsterdam and Brussels: KDS), a clinical stage biopharmaceutical company, today announced a strategic collaboration to support clinical evaluation of an innovative cell therapy product with potential to make haploidentical hematopoietic stem cell transplantations (HSCT) safer and more effective for patients. (globenewswire.com)
  • Kiadis' multinational Phase III clinical trial is evaluating the safety and efficacy of ATIR101 as an adjunctive treatment to HSCT from a half-matched (haploidentical) family donor compared to post-transplant cyclophosphamide (PTCy or "Baltimore" protocol) in adult patients with blood cancers. (globenewswire.com)
  • Administered as an adjunctive immunotherapeutic on top of HSCT, ATIR101 provides a single dose donor lymphocyte infusion (DLI) with functional, mature immune cells from a haploidentical family member. (globenewswire.com)
  • Leukemia
  • Leukemia (Leukaemia) is a cancer of the blood cells. (news-medical.net)
  • Many of the symptoms of leukemia don't become apparent until a large number of normal blood cells are crowded out by leukemia cells. (news-medical.net)
  • Nova Southeastern University researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia patients. (news-medical.net)
  • Advances in rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia. (news-medical.net)
  • More than 30 abstracts presented at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego, December 1-4, featured research highlighting the ability of Bio-Rad's Droplet Digital PCR to provide high sensitivity and accuracy in quantifying minimal residual disease -- those remaining cancer cells after therapy that are associated with relapse -- in blood diseases such as leukemia. (news-medical.net)
  • In addition to the immune response among patients receiving the vaccine, the researchers also observed a small, and surprising, difference between the two groups: Patients who received the vaccine experienced fewer relapses of leukemia (or other underlying disease), and also had a lower risk of mortality from nonrelapse related conditions. (cityofhope.org)
  • Early lymphocyte recovery at 28 d post-transplant is predictive of reduced risk of relapse in patients with acute myeloid leukemia transplanted with peripheral blood stem cell grafts. (springer.com)
  • Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. (wikipedia.org)
  • Currently Aggressive NK-cell leukemia, being a subtype of PTCL, is treated similarly to B-cell lymphomas. (wikipedia.org)
  • We think at least part of the explanation is the drug strips the leukemia cells of their immune defenses, making them more vulnerable to attack by the donor T cells. (eurekalert.org)
  • Simultaneously, the drug makes the leukemia cells more vulnerable to immune attack from the donor T cells, which are now mostly confined to the bloodstream, where the cancer is. (eurekalert.org)
  • Young, ineffective white blood cells in leukemia. (childrensnational.org)
  • tissue
  • The tissue was then sent to Piero Anversa, of Harvard University and Brigham & Women's Hospital in Boston, for processing and to grow cardiac stem cells from Jones' tissue. (bio-medicine.org)
  • A woman who received a donor windpipe seeded with her own stem cells five years ago in groundbreaking surgery is healthy, said a report Wednesday, hailing progress in tissue engineering. (medindia.net)
  • Fat tissue yields many more stem cells than bone marrow (which has been studied before) and is much easier to access. (drugs.com)
  • By contrast, 100 cc's of fat tissue yield millions of stem cells, plenty to work with. (drugs.com)
  • Within 24 hours of the heart attack, doctors performed liposuction to remove fat tissue, isolated 20 million stem cells and gave them back to the patients through a catheter. (drugs.com)
  • Among its other strengths, the PDC is emerging as a world center for the study of stem cells, which are precursor cells with the ability to grow into any tissue and have the capability for treating a variety of human diseases. (innovations-report.com)
  • The phase 1 study of 53 patients found that stem cells from donor bone marrow promoted the growth of new blood vessels in heart tissue damaged by heart attack. (drugs.com)
  • Like in the Berlin patient we were also able to test tissue and we could only find a trace of HIV in tissues of these patients. (natap.org)
  • The study also supports findings from previous, smaller studies, which showed reduced scar tissue in the hearts of patients who received the stem cell treatment, offering additional confirmation that the treatment stimulates the growth of new heart muscle cells. (eurekalert.org)
  • outcomes
  • Dedicated to sound and responsible medical research and collaboration, the Pittsburgh Development Center of Magee-Womens Research Institute explores the molecular biology of cell function to determine the origins of developmental diseases, the causes and prevention of adverse pregnancy outcomes and the potential of stem cells for treating human disease. (innovations-report.com)
  • The researchers will continue to monitor the patients to assess their long-term outcomes. (eurekalert.org)
  • recipients
  • In the results of a phase 1b clinical trial published Dec. 23 in The Lancet Haematology , City of Hope researchers report that an anti-CMV vaccine, known as CMVPepVax, is safe and elicits a protective immune response when administered to stem cell transplant recipients. (cityofhope.org)
  • Design and Methods We investigated the effect of pretransplant anti-donor isoagglutinin reduction by in vivo absorption and/or plasmapheresis on the incidence of pure red cell aplasia and the time to red blood cell engraftment in 153 hematopoietic stem cell transplant recipients with major ABO incompatibility. (haematologica.org)
  • post-transplant
  • At 100 days post-transplant, the researchers found that vaccinated patients had 2.5-fold more protective T cells against CMV, showed less CMV reactivation, and used fewer antiviral drugs. (cityofhope.org)
  • 1 - 3 These incompatibilities include major and bidirectional ABO incompatibility, defined by the presence of isoagglutinins in the recipient against donor red blood cells (RBC) and carry the risk of post-transplant hemolysis. (haematologica.org)
  • researchers
  • She was discharged from hospital 10 days after the operation, but researchers said only a long-term follow-up of the patient could show how succesful the operation had been. (medindia.net)
  • TUESDAY, Nov. 16 -- Stem cells taken from the belly fat of 10 heart attack patients managed to improve several measures of heart function, Dutch researchers report. (drugs.com)
  • The researchers however point out that there are limited number of studies and patients available for analysis and this gap does not allow for 100% accuracy of results. (medindia.net)
  • Comparing data between ET (49 patients) and LT (51 patients) groups, the researchers conclude that ET reduced the length of weaning after tracheostomy and the time to remove the tracheostomy cannula but found no difference in the length of ICU stay and clinical outcome. (medindia.net)
  • Researchers led by Woo Suk Hwang, D.V.M., Ph.D., professor at Seoul National University, previously made history when they announced the first successful cloning of a human embryonic stem cell line in February 2004 at the American Association for the Advancement of Science meeting in Seattle. (innovations-report.com)
  • Before stem cell treatments are developed, PDC researchers will determine the best conditions in which to grow these precious cells. (innovations-report.com)
  • PDC researchers will demonstrate their safety and effectiveness in the laboratory before patients receive stem cell treatments. (innovations-report.com)
  • Many researchers believe that Adipose Stem Cells do cross the Blood/Brain barrier. (cosmeticsurg.net)
  • Researchers then isolated from the marrow a small number of mesenchymal stromal cells and induced the cells to self-replicate. (eurekalert.org)
  • blood
  • The team will continue to evaluate Jones, as well as other patients who have enrolled in the clinical trial, for heart function and blood flow. (bio-medicine.org)
  • ARDS is a lung condition where the patient suffers from sudden breathlessness, low blood oxygen levels and lung inflammation that could progress to respiratory failure. (medindia.net)
  • CD34+ stem cells are the cells that make all the types of blood cells in the body. (clinicaltrials.gov)
  • Six-month results from a 14-patient heart attack trial in the Netherlands and Spain showed not only a reduction in the size of the heart injury but also improvements in the amount of blood supplied to the heart muscle and the amount of blood the heart can pump. (washingtonpost.com)
  • The blood flows through a machine that removes the stem cells. (cancer.gov)
  • Physician-scientists from Children's Hospital of Philadelphia presented updated efficacy and safety data on Kymriah--the first-ever U.S. Food and Drug Administration approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers at the 60th American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance. (news-medical.net)
  • A patient awaiting a kidney transplant has O blood type. (brainscape.com)
  • Rationale 1: If an organ recipient's blood type is O, the only blood type of an organ donator that the recipient can receive must also be O. (brainscape.com)
  • Investigators want to see if special white blood cells, called T cells, that have been trained to kill EBV infected cells can survive in the blood and affect the tumor. (clinicaltrials.gov)
  • After six months, those who got the stem cells were four times more likely to be better off overall, pumped more blood with each heartbeat, and had one-quarter as many irregular heartbeats, when compared to the placebo group. (drugs.com)
  • If you then match with a patient you will be contacted by the ABMDR and asked to confirm your commitment to be a donor and provide another blood sample to confirm this match. (abmdr.org.au)
  • The actual donation method best for you will be assessed by a medical specialist prior to your blood stem cell donation but ultimately you will be able to choose the method of collection. (abmdr.org.au)
  • Normally the number of stem cells circulating in the blood is low. (abmdr.org.au)
  • To increase the number of blood stem cells, a hormone-like substance called Granulocyte Colony Stimulating Factor (G-CSF) is injected under the skin daily for 4 days prior to the collection. (abmdr.org.au)
  • When parents donate cord blood to a public bank, they are supporting patients around the world who are searching for an unrelated Allogeneic donor. (parentsguidecordblood.org)
  • Leukemic cells are invariably present in samples of peripheral blood to a variable extent. (wikipedia.org)
  • Founded in 1997, Kiadis Pharma, is a fully integrated biopharmaceutical company committed to developing innovative therapies for patients with late-stage blood cancers. (globenewswire.com)
  • Red Blood Cells Platelets Fresh Frozen Plasma (FFP) Cryoprecipitated Anti-hemophilic Factor Granulocytes. (slideserve.com)
  • The protein within the red blood cell which carries oxygen. (childrensnational.org)
  • In two of these patients we cannot detect HIV in the blood. (natap.org)
  • Treated patients showed an 8.2-milliliter decrease in the study's primary endpoint, end systolic volume, which indicates the lowest volume of blood in the heart during the pumping cycle and is a key measure of the heart's ability to pump effectively. (eurekalert.org)
  • Therapies
  • Although there are other therapies available for patients with ischemic heart disease, these therapies do not help all patients and many patients continue to face fatigue, shortness of breath and accumulation of fluid in the lungs and legs. (eurekalert.org)