Patients receive high dose chemotherapy doses of chemotherapy or radiation. Medical search. Frequent questions

A team of medical researchers in Italy have achieved what they are calling "excellent" tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. (survivingmesothelioma.com)
After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
Multiple studies have examined the issue of the optimal dose of radiotherapy in NSCLC but are complicated by the heterogeneity of the disease itself in terms of size and location of the primary tumor, number and size of involved lymph nodes, and the patient's comorbidities, all of which limit the treatment tolerability and risks. (frontiersin.org)
Our findings demonstrate that a non-operative approach with high-dose radiotherapy and concurrent chemoradiotherapy can result in favorable outcomes. (mskcc.org)
Background/Aim: Radiotherapy of locally advanced lung cancer often requires high doses potentially leading to pneumonitis. (iiarjournals.org)
The majority of patients with small-cell lung cancer (SCLC) receive radiotherapy in combination with chemotherapy. (iiarjournals.org)
Also, many patients with locally advanced non-small-cell lung cancer (NSCLC) receive radiotherapy, if they are not candidates for surgery. (iiarjournals.org)
Major goals of radiotherapy include local disease control and improvement of the patients' overall prognoses ( 2 ). (iiarjournals.org)
These patients would require a closer monitoring during the course of radiotherapy and several months following treatment. (iiarjournals.org)
Patients received conventionally fractionated radiotherapy of 5×2 Gy per week (on 5 consecutive days). (iiarjournals.org)
In these patients developing pneumonitis following radiotherapy, clinical and treatment characteristics were analyzed to detect potential risk factors for this treatment-related complication. (iiarjournals.org)
In addition, time to progression (local and/or distant failure) was evaluated in the patients developing pneumonitis, which was calculated from the end of radiotherapy. (iiarjournals.org)
Patients with early stage pancreatic cancer could be given longer to live if they receive radiotherapy at a high enough dose, according to research presented at the ESTRO 36 conference. (blogspot.com)
Previous research has suggested that radiotherapy may be of little help to pancreatic cancer patients but the new research indicates that it may have a role to play if it is given at a high enough dose. (blogspot.com)
Following surgery, all the patients had been treated with chemotherapy combined with radiotherapy. (blogspot.com)
Previous research has not shown a benefit for treating pancreatic cancer with radiotherapy, suggesting that these tumors are somehow resistant to radiation, but this study suggests the situation is more nuanced. (blogspot.com)
For patients with early stage tumors, standard treatment is surgery followed by chemotherapy, sometimes with radiotherapy. (blogspot.com)
For later-stage disease, patients are treated with chemotherapy, which may be combined with palliative radiotherapy as their disease progresses. (blogspot.com)
Dr. Cellini said: "Radiotherapy has benefitted from a number of technological improvements over recent years and it is becoming easier to give higher doses that are targeted to the tumour area. (blogspot.com)
This study suggests radiotherapy should be considered for patients with early stage pancreatic cancer. (blogspot.com)
It may also be worthwhile to investigate whether current radiotherapy techniques could also bring survival benefits to patients with more advanced tumors. (blogspot.com)
Dr Cellini is now working with colleagues under the supervision of Professor Alessio Morganti (leader of the presented research) on a study using high-dose radiotherapy, combined with chemotherapy to treat pancreatic cancer patients ahead of surgery. (blogspot.com)
President of ESTRO, Professor Yolande Lievens, head of the department of radiation oncology at Ghent University Hospital, Belgium, said: "This is an interesting study which raises questions about the role that radiotherapy could play in extending the lives of people diagnosed with pancreatic cancer. (blogspot.com)
In this grim disease, radiotherapy has not been shown to have an impact on survival, but the current study suggests the doses previously tested may have been too low to do so. (blogspot.com)
following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

Prior to the advent of cytotoxic chemotherapy, lung cancer at all stages was treated surgically or by radiation alone ( 5 , 6 ). (frontiersin.org)
BT-ON014 trade name] treatment should only be initiated by a health care provider experienced in the administration of cytotoxic chemotherapy (see section 4.4), and should be administered by a health care provider only. (who.int)

A recently conducted clinical trial by the University of Cincinnati showed that by adding an immunotherapy drug to the standard of care treatment regimens, the survival rates for head and neck cancer patients with intermediate-risk features has increased. (nepalnews.com)
Background Preclinical evidence suggests that low-dose radiation may overcome the inhibitory effects of the tumor stroma and improve a tumor's response to immunotherapy, when combined with high-dose radiation to another tumor. (bmj.com)
Conclusions Low-dose radiation may increase systemic response rates of metastatic disease treated with high-dose radiation and immunotherapy. (bmj.com)
By building on the proven concept of conventional chemoradiation for patients with locally advanced NSCLC with a subsequent radiation dose intensification to residual disease with SBRT concurrent with immunotherapy, we hope address the issues of metastatic and local failures. (frontiersin.org)
Seventeen patients (81.0%) received chemotherapy and/or immunotherapy, 12 (57.1%) had significant cardiovascular disease (all 21 patients had risk factors), 11 (52.4%) were heavy smokers (≥40 pack years), 7 (33.3%) were aged ≥74 years, 5 (23.8%) had chronic inflammatory disease and 4 (19.0%) had previous tumors. (iiarjournals.org)
These are slow growing tumors that may be treated with surgery, radiation therapy , the immunotherapy drug rituximab, or occasionally with antibiotics. (dana-farber.org)

The complete remissions have been seen in both patients naïve to CAR T therapies as well as those with CD19 negative relapse after prior CD19-directed CAR T therapy. (centerwatch.com)
The patient had progressed after multiple therapies, including chemotherapy and radiation, prior to receiving JTCR016. (centerwatch.com)
We literally bring surgery, chemotherapies and radiation therapies inside cancer cells. (medicalxpress.com)
Oral complications from cancer therapies are commonly of significant morbidity to the patient and may cause disruption of cancer treatment compromising the prognosis and increase health care costs. (pocketdentistry.com)
An interdisciplinary approach, including dental professionals, is required to work in close collaboration with the patient in order to regularly-and by validated outcome measures-evaluate, prevent, and treat oral complications of cancer therapies. (pocketdentistry.com)

Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)

These results are exciting not only for the positive clinical responses reported but also because they add to the body of data on the lack of renal and other non-hematologic toxicity associated with the use of these very high doses of QUADRAMET. (salesandmarketingnetwork.com)
Dose limiting toxicity was observed at higher doses, so dosing continues at dose level 2 (1 x 10 6 cells/kg). (centerwatch.com)
Our patients are asking us to do better and reduce toxicity. (ascopost.com)
An estimated 80% of patients will have grade 3 toxicity with current treatments, and up to 25% to 60% will "continue to suffer from grade 3 toxicity. (ascopost.com)
According to Sandeep Samant, MD , Chief of Head and Neck Surgery at Northwestern Medicine and symposium Chair, "The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
The goal of deintensification is to reduce late toxicity, while maintaining high survival and normal functioning related to swallowing, saliva, and taste. (ascopost.com)
Additional components include staging (solid tumors), age and performance status of the patient, projected efficacy in relation to toxicity, and patient preferences. (pocketdentistry.com)
The goal of this seminar is to increase your knowledge of asbestos toxicity and your ability to evaluate potentially exposed patients. (cdc.gov)

In the study conducted by independent investigators, four high-risk acute myeloid leukemia (AML) patients (age range 15 to 20 years) received a significantly higher dose of QUADRAMET than the standard palliative dose in combination with chemotherapy conditioning regimens with melphalan (n = 3) or busulfan/cyclophosphamide (n = 1) as preparatory conditioning regimens prior to hematopoietic stem cell transplantation. (salesandmarketingnetwork.com)

For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (nih.gov)
JTCR016, a T cell receptor (TCR) cell product candidate targeting Wilms tumor-1 (WT-1), had data from a phase I trial in patients with acute myelogenous leukemia (AML) at high risk of relapse following an allogeneic hematopoietic stem cell transplant and patients with either mesothelioma or non-small cell lung cancer. (centerwatch.com)
In a phase I dose-escalation trial in patients with AML following allogeneic hematopoietic stem cell transplantation, 11 patients with no measurable disease but at high risk of relapse have been treated to date. (centerwatch.com)
Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)

After surgeons removed as much of the visible mesothelioma tumor and surrounding tissue as possible, patients received 50Gy of radiation to the effected side of their chest, delivered in 25 fractions. (survivingmesothelioma.com)
Delivery of tumoricidal doses to the primary tumor and involved lymph nodes is balanced by treatment-related toxicities, namely esophagitis, pneumonitis, and cardiac injury. (frontiersin.org)
Additionally, JTCR016 continues to show an encouraging safety profile and signals of clinical activity, including evidence of tumor reduction as well as significant T cell expansion and persistence in a patient with mesothelioma. (centerwatch.com)
Frequent characteristics included high mean lung doses, systemic treatment, cardiovascular disease (and risk factors), heavy smoking, older age, chronic inflammatory disease and history of a previous tumor. (iiarjournals.org)
But in a small study in children with a rare kidney tumor, lower doses may have no effect . (kevinmd.com)

The drug has been developed as a treatment for multiple cancers, and Wise-Draper said that it has shown early success as a treatment for head and neck cancers that have spread or returned after initial treatment, with early studies reporting effectiveness for about 20 per cent of patients treated. (nepalnews.com)
Patients with head and neck cancer -- that are treated with the standard surgery, radiation, and potentially chemotherapy if risk factors warrant it -- typically see the cancers return about 30 per cent-50 to cent of the time, Wise-Draper said. (nepalnews.com)
Treatment of various cancers increasingly involves cytoreductive therapy, including high dose chemotherapy or radiation therapy. (justia.com)
Over the last 17 years, stereotactic body radiation therapy (SBRT) has shown a high degree of safety and local control for stage I lung cancers and other localized malignancies. (frontiersin.org)
Chemotherapy for decades was considered "the rule, the dogma," for treating breast cancer and other cancers, said Dr. Gabriel Hortobagyi, a breast cancer specialist. (wanttoknow.info)
The diminution of chemotherapy treatment is happening for some other cancers, too, including lung cancer. (wanttoknow.info)
Radiation is often a key part of cancer treatment for cancers of the esophagus, stomach or pancreas - all near the spleen. (kevinmd.com)
But we don't even know what dose the spleen receives in abdominal cancers, because it hasn't been published. (kevinmd.com)
I tried publishing a small IRB-exempt study measuring spleen dose for abdominal cancers, but peer reviewers at two journals didn't see the relevance. (kevinmd.com)
These patients have a long life expectancy-you can expect them to live 30 to 50 years or even longer as life expectancy continues to increase-vs head and neck cancer patients with disease related to smoking, who are diagnosed in their 60s and have maybe another 10 to 20 years to live because of other smoking-related cancers and medical comorbidities. (ascopost.com)

Because QUADRAMET can provide substantial amounts of radiation specifically to the marrow, the use of this agent in AML may improve the therapeutic index of transplant regimens. (salesandmarketingnetwork.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

Patients and Methods: This study included 278 patients irradiated for locally advanced lung cancer between 2016 and 2019. (iiarjournals.org)
In this retrospective study, which was approved by the ethics committee of the University of Lübeck, 278 patients irradiated for locally advanced lung cancer between 2016 and 2019 were evaluated with respect to the development of symptomatic (grade ≥2) pneumonitis. (iiarjournals.org)

The disease is highly resistant to standard cancer treatments, including chemotherapy, and claims the lives of an estimated 2,500 people in the U.S. each year. (survivingmesothelioma.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
Furthermore it is impossible to predict who will develop severe, erosive disease or who will respond to treatment thus patients are subjected to several rounds of "exploratory" treatments until the right treatment is identified. (dcu.ie)
These rectal cancer patients had faced grueling treatments - chemotherapy, radiation and, most likely, life-altering surgery that could result in bowel, urinary and sexual dysfunction. (wanttoknow.info)
Lapotko said quadrapeutics differs from other developmental cancer treatments in that it radically amplifies the intracellular effect of drugs and radiation only in cancer cells . (medicalxpress.com)
Prior chemotherapy must have included at least an anthracycline and a taxane unless patients are unsuitable for these treatments. (who.int)

For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
Figure 8‐2 ) may be treated by moderate or high‐dose chemotherapy, with or without hematopoietic stem cell transplantation (HSCT). (pocketdentistry.com)

However, this can potentially destroy all the stem-cells in the bone marrow and leave the patient at very high risk for infection. (lymphoma.ca)

In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
Of 20 evaluable patients, 12 (60%) had a partial response, 3 had stable disease and 5 had progressive disease," reported Dr. Hassan in a summary of the findings in Cancer. (survivingmesothelioma.com)
Among the mesothelioma patients who responded to the combination treatment, the research team found a significant decrease in serum levels of mesothelin, as well as other cancer indicators. (survivingmesothelioma.com)
Wise-Draper said the drug caused tumours to begin to die before surgery in nearly 50 per cent of patients, a better rate than what was found when the drug was given for metastatic or recurrent head and neck cancer. (nepalnews.com)
The current standard of care for locally advanced non-small cell lung cancer (NSCLC) includes radiation, chemotherapy, and surgery in certain individualized cases. (frontiersin.org)
Presently, stage III lung cancer is managed with a combination of chemotherapy, radiation therapy, and sometimes surgery but the two major challenges in improving outcomes of the treatment of this disease remain local control and metastatic spread. (frontiersin.org)
Together with our colleagues, we analyzed the results for 11 patients who refused surgery and were treated with radiation, with or without chemotherapy, at Memorial Sloan Kettering Cancer Center between January 2000 and July 2018. (mskcc.org)
Terry J. Fry, M.D., investigator, Pediatric Oncology Branch and head of Hematologic Malignancies Section, National Cancer Institute , National Institutes of Health , reported on CD22-directed CAR T cell therapy (JCAR018) in pediatric and young adult patients with r/r B-cell ALL. (centerwatch.com)
Therefore, this study was performed aiming to identify the prevalence of pneumonitis and potential risk factors for this complication in patients with locally advanced lung cancer irradiated with volume-modulated arc therapy (VMAT). (iiarjournals.org)
It was a small trial, just 18 rectal cancer patients, every one of whom took the same drug. (wanttoknow.info)
said he knew of no other study in which a treatment completely obliterated a cancer in every patient. (wanttoknow.info)
But data from a variety of sources offers some confirmation of what many oncologists say anecdotally - the method is on the wane for many cancer patients. (wanttoknow.info)
Plasmonic nanobubbles act as a "mechanical drug" against cancer cells that cannot be surgically removed and are otherwise resistant to radiation and chemotherapy. (medicalxpress.com)
In cancer cells that survive the initial explosions, the bursting nanobubbles greatly magnify the local doses of both chemotherapy drugs and radiation. (medicalxpress.com)
All three effects-mechanical cell destruction, intracellular drug ejection and radiation amplification-occur only in cancer cells and do not harm vital healthy cells nearby. (medicalxpress.com)
Thanks to the magnifying effect of the plasmonic nanobubbles, the intracellular dose-the amount of the drug that is active inside cancer cells-is very high even when the patient receives only a few percent of the typical clinical dose. (medicalxpress.com)
The gold nanoclusters amplify the deadly effects of radiation only inside cancer cells, even when the overall dose to the patient is just a few percent of the typical clinical dose. (medicalxpress.com)
Every time a cervix and uterus are removed during a simple hysterectomy for presumed benign conditions, they undergo certain testing," explained Eugene Hong, M.D., radiation oncologist at the Genesis Cancer Care Center. (genesishcs.org)
Stacey received a referral to a gynecological oncologist at a Columbus hospital, who recommended treatment at the Genesis Cancer Care Center. (genesishcs.org)
Her team of cancer specialists crafted a personalized package of treatment involving external beam radiation therapy, chemotherapy and an internal high-dose radiation therapy called brachytherapy. (genesishcs.org)
Radiation oncologists offer curative cancer treatment to many. (kevinmd.com)
Since we just had World Pneumonia Day to raise awareness for children, I want to do the same for cancer patients. (kevinmd.com)
Vaccination rates have improved when the spleen is surgically removed , but for cancer patients receiving radiation over half may not receive pneumococcal vaccination . (kevinmd.com)
In the U.S., thousands of abdominal cancer patients may receive incidental spleen radiation each year. (kevinmd.com)
According to the latest update of a key cancer textbook, all patients receiving spleen radiation should receive pneumococcal vaccination. (kevinmd.com)
And the textbook broadly applies the recommendation to all cancer patients, many of whom may qualify based on age or receiving chemotherapy . (kevinmd.com)
And HPV-associated oropharyngeal cancer "is a cancer of relatively younger patients," said Nishant Agrawal, MD , Professor and Director of Head and Neck Surgical Oncology, University of Chicago, at the 2016 Multidisciplinary Head & Neck Symposium sponsored by the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago. (ascopost.com)
We have seen a significant increase in the incidence of HPV-associated oropharyngeal cancer in relatively younger patients, with the median age of diagnosis in the 50s, even patients in their 30s," Dr. Agrawal said. (ascopost.com)
A retrospective analysis 4 of 323 patients with advanced oropharyngeal squamous cell cancer enrolled in a randomized clinical trial found a 3-year overall survival rate of 82.4% for HPV-associated disease vs 57.1% for HPV-negative disease, and progression-free survival of 73.7% vs 43.4%, Dr. Agrawal reported. (ascopost.com)
The National Cancer Institute's Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J. (medscape.com)
for example, intense oral and pharyngeal pain induced by a combination of oral mucositis, oropharyngeal candidiasis, salivary gland hypofunction, and xerostomia frequently lead to dysphagia in cancer patients compromising nutritional intake. (pocketdentistry.com)
As with head and neck cancer patients, factors influencing incidence and severity of oral complications across patients with hematologic disease include extent of oral disease prior to cancer treatment, intensity of cancer therapy, genetically‐governed susceptibility to oral mucosal injury, and patient compliance with health professional Recommendations regarding oral hygiene, diet, smoking cessation, and related variables. (pocketdentistry.com)
He told the conference: "Survival rates for pancreatic cancer remain stubbornly low, with most patients given months rather than years to live. (blogspot.com)
One of the reasons why pancreatic cancer has a high mortality rate is that it produces very few symptoms in its early stages and by the time it is diagnosed, it has already spread. (blogspot.com)
Dana-Farber/Boston Children's also offers a wide array of support services and programs for pediatric patients and their families during and after cancer treatment. (dana-farber.org)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)

Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)

While previous studies have shown some promise in SS1P treatment by itself, especially when the immune system is suppressed, the newest study tests the value of SS1P in combination with the most popular mesothelioma chemotherapy drugs, pemetrexed and cisplatin. (survivingmesothelioma.com)
And although we're careful to say cure, it does result in what is called 'durable responses,'" she said, explaining that means patients have a good response to treatment much longer than expected, sometimes for years, "which was a huge advancement over chemotherapy where they may have only been effective for say nine to 10 months at most," Wise-Draper said. (nepalnews.com)
To accomplish this goal, tissue and blood samples were collected before and after administering the drug to analyze factors that contributed to patients responding to the treatment. (nepalnews.com)
Less than 70 per cent of patients in the intermediate group who were treated with radiation alone after surgery was typically disease-free one year following treatment, but more than 95 per cent of patients in the trial reported one-year disease-free survival when treated with both radiation and pembrolizumab. (nepalnews.com)
The success of treatment crucially depends on the mobilization of the bone marrow stem cells, the subsequent return of which permits the patient to achieve reconstitution of a functioning hematopoietic system. (justia.com)
Two high-risk AML patients remain in continuous complete remission with excellent quality of life (one patient greater than 2-years, another greater than 4-years) following the treatment regimen with high dose QUADRAMET. (salesandmarketingnetwork.com)
The group at the Mayo Clinic has pioneered investigations into the use of high dose QUADRAMET in the treatment of hematologic malignancies including multiple myeloma and AML," said William Goeckeler, Ph.D., Senior Vice President of Operations at Cytogen. (salesandmarketingnetwork.com)
Twenty-six (of 155) patients received low-dose radiation (1-20 Gy total), either as scatter from high-dose radiation or from intentional treatment of a second isocenter with low-dose radiation, were evaluated for response. (bmj.com)
However, for patients with more locally advanced NSCLC, 5-year OS after treatment with definitive radiation therapy and concurrent chemotherapy remains modest, at approximately 15-20% ( 4 ). (frontiersin.org)
Examples of secondary immunodeficiency include HIV infection, hematopoietic malignancies, treatment with radiation, and treatment with immunosuppressive drugs. (cdc.gov)
Bone marrow or stem cells that have been removed from a donor are carefully frozen and stored while the patient receives high-dose chemotherapy and sometimes whole-body radiation treatment. (lymphoma.ca)
Limited cytokine release syndrome (CRS) was seen at dose level 2, with two patients at Grade 1 and one patient at Grade No severe neurotoxicity was observed in these treatment cohorts. (centerwatch.com)
In patients experiencing symptomatic pneumonitis, patient and treatment characteristics were analyzed. (iiarjournals.org)
Therefore, it would be desirable to identify patients, who are at high risk of developing radiation pneumonitis, prior to the start of treatment. (iiarjournals.org)
Treatment characteristics included mean dose to the ipsilateral lung and type of systemic treatment. (iiarjournals.org)
The result spares thousands each year from the dreaded chemotherapy treatment, with its accompanying hair loss, nausea, fatigue, and potential to cause permanent damage to the heart and to nerves in the hands and feet. (wanttoknow.info)
Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
Received 18 February 2006 the primary operation, but some will recur in spite of this treatment. (lu.se)
Patients and methods proportion of the patients will recur despite treatment with adjuvant polychemotherapy. (lu.se)
According to treatment guidelines in the regional care pro- recur in spite of chemotherapy. (lu.se)
In order to achieve a more effec- were recommended postoperative radiation and adjuvant tive and individualised chemotherapeutic treatment of breast chemotherapy. (lu.se)

Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
An early dose-finding study by the Radiation Therapy Oncology Group (RTOG) 7301 study was conducted from 1973 to 1978 and studied four different doses and schedules: 40 Gy split course, 40 Gy continuously, 50 Gy, and 60 Gy. (frontiersin.org)
Stem cells, because they divide rapidly, can be killed off by chemotherapy and radiation therapy. (lymphoma.ca)
Therefore, the doses of chemotherapy and radiation therapy used to treat lymphoma are limited due to the risk of damaging these stem cells. (lymphoma.ca)
Patients with lymphomas that are difficult to treat or resistant to standard therapy may benefit from chemotherapy or radiation therapy given in very high doses (myeloablative therapy). (lymphoma.ca)
This means that they receive stem cells (either their own stem cells that were stored prior to myeloablative therapy or stem cells from a donor) to replenish their bone marrow which had previously been destroyed by the high-dose therapy. (lymphoma.ca)
High-dose chemotherapy, with or without myeloablative radiation therapy, is then administered to the patient to destroy the cancerous cells, as well as the healthy cells in the bone marrow. (lymphoma.ca)
I ended up having five rounds of chemotherapy, 25 doses of radiation therapy and two doses of internal radiation. (genesishcs.org)
Even at 2 years after radiation therapy, 15% of patients had grade 2 swallowing dysfunction and 8% had progressive dysphagia, so their swallowing is going to continue to get worse. (ascopost.com)
For a long time, stem cells have been utilized to renew the immune system for radiation or chemo- therapy treated patients. (bmrat.org)
Ionizing radiation is emitted by radioactive elements and by equipment such as x-ray and radiation therapy machines. (msdmanuals.com)
2 cm in diameter, as adjuvant therapy following neoadjuvant chemotherapy and surgery (see sections 4.4 and 5.1). (who.int)

They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
Patients who received a dose less than 45 Gy had an average survival of 13 months, patients with a dose in the range of 45 to less than 50 Gy had an average survival of 21 months. (blogspot.com)
For the next group with a dose range of 50 to less than 55 Gy, average survival was 22 months and for the group with the highest doses of 55 Gy or more, average survival was 28 months. (blogspot.com)
The pattern of increasing survival in this study suggests that tumors of the pancreas are not resistant to radiation, they just need to be tackled with an adequate dose. (blogspot.com)

High-risk features included secondary AML and a chromosomal defect known as monosomy 7 (n = 1), chemotherapy induction failure (n = 1), and AML in relapse (n = 2). (salesandmarketingnetwork.com)
The high‐dose induction chemotherapy regimen that will be used to treat this patient is profoundly myelosuppressive, and typically causes severe ulcerative oral mucositis for at least two weeks duration. (pocketdentistry.com)

Dr. Cellini added: "Even in developed countries, perhaps only a quarter of patients are picked up early enough to have their tumors surgically removed. (blogspot.com)

The harvested stem cells or bone marrow (obtained from either the patient's own healthy cells or from a donor) are then transplanted intravenously into the bloodstream of the patient. (lymphoma.ca)

The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
QUADRAMET is indicated for the relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan. (salesandmarketingnetwork.com)
To combat this problem, the patient receives a bone marrow or a stem-cell transplant. (lymphoma.ca)
Stem cells or bone marrow harvested from the patient (autologous transplant) are generally preserved and stored in a freezer until ready for use. (lymphoma.ca)
Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (msdmanuals.com)

As previously reported, six patients were treated at the lowest dose, with one patient achieving a complete remission (CR) and complete molecular remission as measured by flow cytometry (CmR). (centerwatch.com)
These patients remain in complete remission with follow-up ranging from three to six months. (centerwatch.com)
A complete remission in every single patient is "unheard-of," he said. (wanttoknow.info)

The publication, "Marrow irradiation with high-dose 153 Samarium-EDTMP followed by chemotherapy and hematopoietic stem cell infusion for acute myelogenous leukemia" by Vilmarie Rodriguez, M.D., a Pediatric Oncologist at The Mayo Clinic in Rochester, Minnesota, appears in a recent issue of the peer-reviewed journal Leukemia & Lymphoma (Leuk Lymphoma. (salesandmarketingnetwork.com)
Matthew Katz is a radiation oncologist. (kevinmd.com)
The research was presented by Dr. Francesco Cellini, radiation oncologist at the Fondazione Policlinico Universitario Agostino Gemelli and the Università Cattolica del Sacro Cuore, Rome, Italy. (blogspot.com)

To support evidence-based clinical guidelines on erythropoietin use for anemia in oncology, we conducted systematic reviews of controlled trials on four patient groups. (cancernetwork.com)
I have recently shown that synovial tissue poly-T-cells can predict RA-patient stratification, correlate with disease progression in RA and PsA and importantly, are present at the joints of at risk-individuals prior to development of clinical-inflammation. (dcu.ie)
The positive clinical responses observed in this group of high-risk patients indicate that further evaluation of this therapeutic approach is warranted. (salesandmarketingnetwork.com)
Local and distant failure remains high in this group of patients, so dose escalation has been studied in both single institution and national clinical trials. (frontiersin.org)
Social workers participating in this intermediate to advanced course will receive 5 Clinical continuing education clock hours. (netce.com)
The Working Formulation, originally proposed in 1982, classified and grouped lymphomas by morphology and clinical behavior (ie, low, intermediate, or high grade) with 10 subgroups labeled A to J.{Ref 1} In 1994, the Revised European-American Lymphoma (REAL) classification attempted to apply immunophenotypic and genetic features in identifying distinct clinicopathologic NHL entities. (medscape.com)

This is defined by their ability to repopulate an individual whose hematopoietic system has been destroyed by radiation or chemotherapy. (justia.com)
In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)

Symptoms may be local (eg, burns) or systemic (eg, acute radiation sickness). (msdmanuals.com)

Publications on infection from spleen radiation date back at least thirty years, but were limited to lymphoma and postsplenectomy patients. (kevinmd.com)
With Hodgkin's lymphoma, high doses to the spleen can cause atrophy . (kevinmd.com)

Results: Pneumonitis was diagnosed in 21 patients (7.6%) after a median of 9 (1-23) weeks. (iiarjournals.org)
For example, polonium-210 (Po-210) has a specific activity of 166 terabecquerels per gm (TBq/g), and 1 mcg (about the size of a grain of salt) of Po-210 delivers a whole body dose of 50 Sv (~20 times the median lethal dose). (msdmanuals.com)

An important new study from one of the country's top mesothelioma research labs has found a way to significantly boost the impact of chemotherapy on mesothelioma patients who are not eligible for surgery. (survivingmesothelioma.com)
Patients enrolled in the trial were given one dose of the drug before surgery and were evaluated for risk status and grouped into intermediate- and high-risk groupings after surgery. (nepalnews.com)
A patient is considered high risk if part of the tumour is still left behind after surgery or is not contained in a lymph node. (nepalnews.com)
All patients continued to receive the appropriate standard of care (radiation alone for intermediate-risk or radiation and chemotherapy for high risk), with six more doses of pembrolizumab also administered after surgery. (nepalnews.com)
Design, Setting, and Participants: Pre/post interventional study of a risk stratification algorithm in patients aged 6 to 21 years undergoing surgery for an ovarian mass in an inpatient setting in 11 children's hospitals in the United States between August 2018 and January 2021, with 1-year follow-up. (bvsalud.org)
Conclusions and Relevance: Unnecessary oophorectomies decreased with use of a preoperative risk stratification algorithm to identify lesions with a high likelihood of benign pathology that are appropriate for ovary-sparing surgery. (bvsalud.org)
The study retrospectively analyzed 514 patients from Europe and the US who were diagnosed when their tumors had not spread and could be removed by surgery. (blogspot.com)

Acute radiation syndromes can be caused by a sufficient dose of some internally deposited radionuclides that are widely distributed in tissues and organs and have a high specific activity. (msdmanuals.com)

In a pharmacokinetic study of BUSULFEX in 24 pediatric patients, the population pharmacokinetic (PPK) estimates of BUSULFEX for clearance (CL) and volume of distribution (V) were determined. (nih.gov)
JCAR018 is a chimeric antigen receptor (CAR) T cell product candidate targeting CD22, and had data from a phase I trial in pediatric and young adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (r/r ALL). (centerwatch.com)
BACKGROUND: Technetium-99 (99m Tc) lymphoscintigraphy with blue dye injection is an accepted method for sentinel lymph node (SLN) mapping, but blue dye has known adverse effects, and injection of 99m Tc may increase time under anesthesia for pediatric patients. (bvsalud.org)

The study concludes, "SS1P given with pemetrexed and cisplatin is safe and well tolerated and exhibits significant antitumor activity in patients with unresectable, advanced pleural mesothelioma. (survivingmesothelioma.com)

Genetic tests can now reveal whether chemotherapy would be beneficial. (wanttoknow.info)
HSCT‐related oral toxicities are additionally influenced by the degree of genetic disparity between donor and patient. (pocketdentistry.com)
which may render the genetic mate doses of NDMA is the kidney, but a Transplacental carcinogenesis rial of fetal cells highly accessible to much lower incidence of tumours is stu dies with ENU in nonhuman pri carcinogens. (who.int)

Results The 26 patients had a total of 83 lesions for comparison (38 receiving low-dose, 45 receiving no-dose). (bmj.com)
The average dose given to low-dose lesions was 7.3 Gy (1.1-19.4 Gy), and the average time to response was 56 days. (bmj.com)
Twenty-two out of 38 (58%) low-dose lesions met the PR/CR criteria for RECIST compared with 8 out of 45 (18%) no-dose lesions ( P = 0.0001). (bmj.com)
Conversely, two (4%) of the no-dose lesions responded without a corresponding response in their low-dose lesion ( P = 0.0004). (bmj.com)

Importantly, this results in severe debilitating trauma for the patients. (dcu.ie)
JTCR016 was generally well-tolerated in these three patients, with no evidence of severe CRS or severe neurotoxicity. (centerwatch.com)

The stem cells are separated from other components of the blood in a process called apheresis, with the rest of the blood being returned to the patient. (lymphoma.ca)

Radiation is a feasible option for patients with squamous cell carcinoma of the anterior nasal cavity mucosa who refuse rhinectomy, according to our recent research. (mskcc.org)
However, if that's not feasible, a heterologous additional dose is permitted. (cdc.gov)

Ototoxicity is typically associated with bilateral high-frequency sensorineural hearing loss and tinnitus. (medscape.com)

The data from JCAR018 suggest two paths to improve outcomes-use in patients with CD19 negative disease and a combination of CD19 and CD22 to decrease the risk of resistant cells and increase the percentage of patients that demonstrate a long-term durable remission in B cell malignancies. (centerwatch.com)

We could see that a lot of these tumours were dying even after that first dose of pembrolizumab," Wise-Draper said. (nepalnews.com)
This chapter exposed adults, with a shorter laten onal solid tumours, are observed as summarizes the literature that docu cy period from the time of exposure tumours of adult life in conventional ments this high susceptibility of the to the carcinogen until the appear rodents. (who.int)
Studies in experimental incidence and multiplicity of tumours to Wilms tumour in humans - in the animals increase and the latency period de adult rat after perinatal exposure to a creases with increasing dose. (who.int)

The degree to which immunosuppressive drugs cause clinically significant immunodeficiency generally is dose related and varies by drug. (cdc.gov)
Another surprise, Dr. Venook added, was that none of the patients had clinically significant complications. (wanttoknow.info)

The dose of QUADRAMET administered to the patients was 19 mCi/kg (n = 1) and 30 mCi/kg (n = 3), compared to the approved 1 mCi/kg dose used in the palliative setting. (salesandmarketingnetwork.com)

e) Specific immune globulin: Special preparations obtained from blood plasma from donor pools preselected for a high antibody content against a specific antigen (e.g., hepatitis B immune globulin, varicella-zoster immune globulin, rabies immune globulin, tetanus immune globulin, vaccinia immune globulin, and cytomegalovirus immune globulin). (cdc.gov)

More recently, phase I/II studies using SBRT for dose escalation after conventional chemoradiation in locally advanced NSCLC have been promising with good apparent safety. (frontiersin.org)
Forty percent of these patients present with locally advanced disease ( 3 ). (frontiersin.org)
Patients with locally advanced disease who had distant metastases were also included. (iiarjournals.org)

Patients received between 25 and 55 mcg/kg of SS1P along with their regular chemotherapy on days 1, 3 and 5 during their first and second chemotherapy cycles. (survivingmesothelioma.com)

Chemotherapy and radiation are commonly used to treat the residual portions of these tumors, but some tumors become resistant to chemoradiation. (medicalxpress.com)

In the current prospective study, 20 malignant pleural mesothelioma patients underwent radical pleurectomy/decortication followed by high doses of radiation. (survivingmesothelioma.com)
METHODS: Thirty patients (36 procedures with 96 total specimens) underwent preoperative intradermal injection of 99m Tc, followed by intradermal injection of isosulfan blue and ICG. (bvsalud.org)

Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)
Most experimental studies of the predominant results of earlylife do not develop in rats exposed to the carcinogenesis during prenatal life exposure are what would be expect same carcinogen during adult life and infancy have been conducted ed from a higher effective dose to the (Diwan and Rice, 1995 ). (who.int)

The responses appear to correlate with the pharmacokinetics of the engineered T cells, as the patient with the partial response had the best T cell expansion and persistence. (centerwatch.com)

People exposed to radiation may be divided into "low-risk" and "high-risk" susceptibility groups, based on degree of neutropenia and the presence of comorbidities. (msdmanuals.com)

Anatomy3

Organisms2

Diseases73

Chemicals and Drugs63

Analytical, Diagnostic and Therapeutic Techniques and Equipment84

Phenomena and Processes24

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science5

Health Care42

Radiotherapy27

Cytotoxic chemotherapy2

Immunotherapy6

Therapies5

Requires high doses1

Toxicity8

Acute Myeloid1

Allogeneic6

Tumor5

Cancers10

Regimens2

20192

Treatments6

Transplantation2

Potentially1

Cancer38

Cyclophosphamide1

Treatment22

Therapy12

Survival4

Induction2

Surgically removed1

Patient's1

Bone6

Complete remission3

Oncologist3

Clinical6

Hematopoietic2

Systemic1

Lymphoma2

Median2

Surgery7

Organs1

Pediatric3

Unresectable1

Genetic3

Lesions4

Severe2

Stem cells1

Feasible2

Typically1

Combination1

Tumours3

Clinically significant2

Palliative1

Donor1

Locally advanced3

Cycles1

Residual1

Underwent2

Exposure2

Responses1

Susceptibility1