Patients primary tumor neoplasm micrometastasis. Medical search. Frequent questions

The most serious complications of carcinoid tumors are carcinoid syndrome /crisis and metastasis, which is often observed in patients who have foregut tumors and high levels of 5-HIAA. (medscape.com)
[ 125 ] In patients with carcinoid tumors located in the appendix, age, primary tumor size, histologic features, lymph node involvement, and distant metastasis are significant factors in predicting survival. (medscape.com)
Overall, localized carcinoid tumor which is completely resected has an excellent prognosis, the outcome for patients with metastasis, however, remains poor. (medscape.com)
Growth factors and cytokines involved in liver regeneration have also been shown to influence tumour growth and metastasis. (nih.gov)
Thyroidectomy can be considered in patients with no other metastasis or in those who present compressive symptoms as a palliative measure. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, with a previously known bone metastasis of renal origin and symptomatic goiter containing a nodule that was found to be a metastasic lesion. (scirp.org)
We expose the case of a patient with clear cell type renal cell carcinoma, thyroid metastasis with a previously known bone metastasis of renal origin and large goiter with compressive symptoms. (scirp.org)
Dr. Welm's group discovered that the Ron kinase pathway is an important facilitator of breast cancer metastasis through its unique dual function in tumor cells and in resident macrophages. (utah.edu)
VCAM-1 expression was demonstrated in human brain metastasis samples, across all three primary tumor types. (ox.ac.uk)
These findings represent an important step forward in the development of a broadly applicable and clinically relevant imaging technique for early diagnosis of brain metastasis, with significant implications for improved patient survival. (ox.ac.uk)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
This is defined by the depth, ulceration status and mitotic rate of the primary tumor, the presence of regional nodal disease or distant metastasis. (amegroups.org)
There was a recent update to the 2002 American Joint Committee on Cancer (AJCC) TNM-tumor, lymph node and metastasis-staging system in 2009 and newer prognostic factors that have clinical implications were added ( 2 ). (amegroups.org)
Contrast computed tomography (CT)/positron emission tomography (PET), contrast nuclear magnetic resonance (MRI) and surgical exploration were used to ensure whether all PC patients meet our resection criteria as Sugiura et al previously reported [9], including: a) no distant metastasis, b) tumor extension to the superior mesenteric artery or celiac trunk was less than 90°and can be completely resected and constructed. (researchsquare.com)
Clinical characteristics and treatment of gestational trophoblastic tumor with vaginal metastasis. (medscape.com)
This study proposes CTC biomarkers and signaling pathways implicated in BCBM that may be used either as a screening tool for brain micro-metastasis detection or for making rational treatment decisions and monitoring therapeutic response in patients with BCBM. (houstonmethodist.org)
IACS-010759 treatment of an RCAS-TVA mouse model of spontaneous MBM and lung metastasis significantly decreased the incidence of detectable MBMs but did not affect primary tumor growth or the incidence of lung metastases. (tmc.edu)
Further, while OXPHOS is not a critical determinant of brain metastasis formation, it plays a crucial role in intracranial tumor growth. (tmc.edu)
Early T stage GBC patients with distant metastasis are proven to have a worse prognosis. (medsci.org)
Younger age, high pathological grade, nonadenocarcinoma, T1, N1 and larger tumor size correlated positively with the risk of distant metastasis. (medsci.org)
A novel nomogram was established to predict distant metastasis in early T stage GBC patients. (medsci.org)
Although some limitations exist in this predictive model, the nomogram revealed the relationship between the clinicopathological characteristics of T1 and T2 GBC patients and the risk of distant metastasis. (medsci.org)
For patients with resected T2 lesions, 16% have been found to have distant metastasis [ 3 ]. (medsci.org)
the liver, an adjacent organ, is the leading metastatic site, accounting for over 50% of GBC patients with metastasis [ 4 ]. (medsci.org)
Particularly for early T stage patients, such as T1 and T2, oncologists or hepatobiliary surgeons may overlook the possibility of distant metastasis, resulting in insufficient preoperative diagnostic examinations, follow-up, and postoperative comprehensive treatment. (medsci.org)
The strongest predictive factor for patient survival in patients with colon cancer is lymph node metastasis ( 2 ). (turkjsurg.com)
It has been estimated that 20-30% patients with early-stage node-negative disease will develop distant metastasis despite adequate surgical resection ( 3 ). (turkjsurg.com)
It is widely accepted that tumor metastasis is a formidable barrier to effective treatment of lung cancer. (hindawi.com)
Bone metastasis is a major determinant of treatment outcome, quality of life, and survival for lung cancer patients [ 12 - 14 ]. (hindawi.com)
Results Methylene blue dye staining and localisation of SLNs were positive in 22 (88%) patients, out of which 10 (45.45%) patients had SLN which were positive for metastasis. (bvsalud.org)
In three patients (12%), the dye failed to reach the axilla with one patient having micro-metastasis in the axillary lymph nodes. (bvsalud.org)
No adjuvant therapy was given because the size of tumour was small, there was no residual tumor in mastectomy specimen and she had no distant metastasis. (bvsalud.org)
Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
Lymph node metastasis is one of the factors in cancer patients that is predictive of prognosis. (biomedcentral.com)
We conducted the present study to determine the relationships between the occurrence of late cervical lymph node metastasis and clinicopathological factors in patients with early TSCC, and we examined the effective factors that could be useful to predict late cervical lymph node metastasis in patients with early TSCC. (biomedcentral.com)
Prior to the initial surgery, all of the patients were confirmed by contrast-enhanced CT, US, contrast-enhanced MRI and/or FDG-PET to be without cervical lymph node metastasis, distant metastasis, or multiple cancers of other organs. (biomedcentral.com)
Therefore, radiologic, endoscopic and pathologic evaluation to predict the risk of lymph node metastasis and local recurrence has been evolving to determine the optimal treatment strategy in the patient-tailored medicine. (pfmjournal.org)

In adult patients, factors associated with poor survival include persistence of plasma neurokinin A (NKA), urinary 50-hydroxyindolacetic acid output, age, and 5 or more liver metastases. (medscape.com)
Clear cell renal carcinoma (CCRC) is a tumor with great metastatic capacity, although the presence of metastases in the thyroid gland is very uncommon. (scirp.org)
At a time when modern radiation treatment like intensity-modulated radiotherapy (IMRT) are accomplishing great good local control, distant metastases are getting to be the transcendent design of treatment failure, particularly in patients with locally progressed illness. (intechopen.com)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
Eleven of the 23 patients were alive 24 months later, suggesting that brain metastases is not an imminent death sentence. (medscape.com)
This is consistent with the data we have seen from the CheckMate 204 study that was relatively recently published in New England Journal of Medicine, [ 4 ] which suggests that patients with brain metastases can clearly have benefit from immunotherapy. (medscape.com)
The growth of solid tumors and the formation of metastases depend on angiogenesis. (elsevierpure.com)
Radiation therapy may provide palliative relief from symptomatic metastases, control recurrent tumors, and prevent recurrence of advanced resected tumors. (medscape.com)
We recently showed via RNA-sequencing (RNA-seq) analysis of clinical samples that melanoma brain metastases (MBMs) have higher expression of oxidative phosphorylation (OXPHOS) genes (including PPARGC1A or PGC1α ) than patient-matched extracranial metastases (ECMs). (tmc.edu)
To clarify if OXPHOS promotes the formation of MBMs or the outgrowth of micrometastases, we used an imageable experimental MBM model to demonstrate that IACS-010759 treatment prevented the growth of MBMs but did not prevent their formation, and had no effect on the formation or growth of lung metastases. (tmc.edu)
A large part of the mortality rate from cancer, as well as tumor recidivism, is due to the staging and the presence or absence of metastases, where it has metastasized and whether there are micro- or macro-metastases. (encyclopedia.pub)
Bone metastases can cause a wide range of symptoms that could impair quality of life of lung cancer patients and shorten their survival. (hindawi.com)
We strongly believe that molecular targets (tumor-related and bone microenvironment based) that have been implicated in lung cancer bone metastases hold great promise in lung cancer therapeutics. (hindawi.com)
In fact, over two-thirds of lung cancer patients have regional lymph-node involvement or distant metastases at the time of presentation [ 3 ]. (hindawi.com)
Although there are currently some available palliative treatment options for patients with bone metastases from any solid tumor origin such as radiation therapy and bone targeted/bone strengthening treatments (bisphosphonates and denosumab) that are used in clinical practice, none of them is specific for lung cancer metastases and they do not affect the poor survival outcome of this disease. (hindawi.com)
Using current diagnostic methods, we are still unable to identify patients especially prone to metastases. (czytelniamedyczna.pl)
The presence of such cells in the blood coexists with micrometastases, which are clinically silent, and/or precedes the clinical emergence of metastases (4). (czytelniamedyczna.pl)
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)

Hricak et al (1991) used MRI for diagnostic evaluation of the female urethra in a series of patients and found that primary or metastatic urethral neoplasms were detected in every patient who was clinically found to have disease. (medscape.com)
and (4) refining "precision medicine" for metastatic breast cancer using functional assays in patient-derived breast tumor grafts. (utah.edu)
Kluger and colleagues [ 3 ] treated 23 patients with metastatic melanoma, the majority (70%) of whom had received prior therapy. (medscape.com)
In in vivo experiments antiangiogenic agents with cytotoxic anticancer drugs formed a highly effective modulator combination for the treatment of the Lewis lung carcinoma against primary and metastatic disease. (elsevierpure.com)
One of the drugs in multiagent chemotherapy regimens used to treat patients with high-risk metastatic GTN. (medscape.com)
What is the best protocol of single-agent methotrexate chemotherapy in nonmetastatic or low-risk metastatic gestational trophoblastic tumors? (medscape.com)
Roberts JP, Lurain JR. Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. (medscape.com)
The enumeration of EpCAM-positive circulating tumor cells (CTCs) has allowed estimation of overall metastatic burden in breast cancer patients. (houstonmethodist.org)
Nevertheless, radioactive iodide treatment is used for most patients with Hürthle cell cancers after total and near-total thyroidectomy and in the treatment of patients with recurrent and metastatic Hürthle cell carcinoma. (medscape.com)
ICG guided SLN biopsy can identify metastatic lymph nodes in colon cancer patients that can be missed on H & E staging with relatively higher sensitivity for early (T1/T2) tumours. (turkjsurg.com)
The bone is one of the frequent metastatic sites for lung cancer occurring in a large number of patients. (hindawi.com)
For instance, the five-year survival rate for patients with (stage IA) after surgical resection is close to 70% but the five-year survival rate for patients with stage IV (metastatic disease) is as low as 2% [ 4 ]. (hindawi.com)
In spite of the advances in treatment of primary malignancy, cases of relapse and metastatic spread have created major hurdles to reaching the desired treatment outcome [ 7 ]. (hindawi.com)
A real-world survival analysis showed that patients with metastatic RCC treated with axitinib plus pembrolizumab did not experience significantly improved survival outcomes compared with patients treated with ipilimumab plus nivolumab. (oncnursingnews.com)
Circulating Tumour Cells (CTC) are a population of cells that have detached from the tumour mass and are able to disseminate via the vascular system and create metastatic foci in the body (1). (czytelniamedyczna.pl)

However, long-term survival in these patients is limited by the high incidence of tumor recurrence. (nih.gov)
The risk of recurrence and death after complete surgical resection of clinically detectable primary cutaneous melanoma ranges from low, intermediate to high risk depending on the stage of disease at diagnosis. (amegroups.org)
For high-risk melanoma, adjuvant therapy aims at eradicating melanoma micrometastases in those patients that carry an unacceptable risk of mortality from melanoma recurrence. (amegroups.org)
Giant cell tumor (GCT) of bone is a benign but locally aggressive tumor with tendency for local recurrence [2]. (jbstjournal.com)
Goals of treatment are to achieve satisfactory removal of the tumor, lessen the chance of local recurrence and to preserve as much wrist function as possible. (jbstjournal.com)
One of the reasons for recurrence in pathologically node-negative patients could be missed micrometastasis and occult tumor cells on routine histopathological examination or inadequate lymph node harvesting leading to understaging ( 4 ). (turkjsurg.com)
The presence of micrometastases may cause osteosarcoma recurrence following local treatment with surgery alone. (radiationoncologyassociates.co)

Immunologically "cold" triple negative breast cancers engraft at a higher rate in patient derived xenografts. (utah.edu)
I+II vs III+IV, P=0.002) were closely associated with the progression of pbt cancers compared with that in ph cancer patients. (researchsquare.com)
Moreover, tumor size≥3cm (P=0.012), 8th AJCC stage (III+IV) (P=0.025) and PLM (P=0.010) were identified as independent risk factors in pbt cancers in logistic analysis. (researchsquare.com)
Patients with pbt cancers had a significantly worse overall survival compared with ph cancer patients (P=0.007). (researchsquare.com)
Conclusion: Pbt, as an independent unfavorable factor for the prognosis of PC patients, are much more aggressive than that in ph cancers according to 8th AJCC staging system. (researchsquare.com)
it represents one of the most common cancers, and is among the leading causes of tumor death. (encyclopedia.pub)
Hemangiosarcoma accounts for 5% of all visceral neoplasms 3 (organ cancers) and about 50% of splenic malignancies (spleen cancers) in dogs. (dogcancer.com)
Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)
Prospective studies have demonstrated the effectiveness of identifying and quantifying CTCs in the prediction of malignant tumour treatment outcomes, including cancers of the breast, colon and prostate (3). (czytelniamedyczna.pl)
CTCs can be isolated from patients' blood in the course of most cancers due to the ease of identification of the epithelial phenotype of the cancer. (czytelniamedyczna.pl)
Tumors or cancers of the KIDNEY. (lookformedical.com)
The overall effectiveness ranges from being curative for some cancers, such as some leukemias, to being ineffective, such as in some brain tumors, to being needless in others, like most non-melanoma skin cancers. (worldsbest.rehab)

Several authors have studied the potential of sentinel lymph node (SLN) tumor burden as prognostic factor but the microscopic classifications used in different study groups were variable. (bvsalud.org)
The aim of this study was to correlate tumour burden in SLNs with that in the residual lymph node basin to determine the likelihood of residual disease in patients with micro- and macrometastasis in the SLN. (ox.ac.uk)
Sentinel lymph node (SLN) biopsy technique has been described in colon cancer to detect micrometastasis (MM) ( 6 ). (turkjsurg.com)
This study was conducted to evaluate the role of SLN biopsy using NIR-fluorescence in colon cancer patients with respect to detection rate, upstaging rate, frequency of aberrant lymph node drainage, accuracy, and sensitivity of the SLN biopsy procedure. (turkjsurg.com)
The aim of this study was to investigate the ease and the effectiveness of using methylene blue dye in the localisation of sentinel lymph node (SLN) and biopsy (SLNB) in patients undergoing surgery for breast cancer at RIPAS Hospital. (bvsalud.org)
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Patients with early TSCC generally achieve good outcomes by undergoing the surgical resection of primary sites, [ 2 ] but there some cases of stage I/II TSCC metastasize to one or more cervical lymph nodes after the surgical resection of the primary site and become difficult to control. (biomedcentral.com)
There is no evidence of a breast tumor, but there are small areas of cancer in the underarm (axillary) lymph nodes measuring at least 0.2 millimeters but are no larger than 2 millimeters in size, called micrometastasis . (lbbc.org)
There is a breast tumor that is 2 centimeters or less across, including as small as 1 millimeter or less (microinvasive breast cancer), and there are small areas of cancer in the axillary lymph nodes (micrometastasis) measuring at least 0.2 millimeters but are no larger than 2 millimeters in size. (lbbc.org)
There isn't any evidence of a breast tumor, but there is cancer in one to three axillary lymph nodes or internal mammary lymph nodes (near the breastbone, identified with sentinel lymph node biopsy ). (lbbc.org)
The tumor is 2 centimeters or less across and there is cancer in one to three axillary lymph nodes and/or internal mammary lymph nodes. (lbbc.org)
The tumor is between 2 and 5 centimeters across and there is no cancer in the lymph nodes. (lbbc.org)
The tumor is between 2 and 5 centimeters across and there is cancer in one to three axillary lymph nodes or internal mammary lymph nodes (near the breastbone, sometimes identified with sentinel node biopsy ). (lbbc.org)
The tumor is more than 5 centimeters across and there is no cancer in the lymph nodes, or a tiny amount of cancer has been detected in lymph nodes at a size smaller than 0.2 millimeters. (lbbc.org)
There is no evidence of a tumor , or there is a tumor of any size and cancer is found in four to nine axillary lymph nodes, or the cancer has caused the internal mammary lymph nodes near the breastbone to become enlarged. (lbbc.org)

CONCLUSION: Patients may be advised to forgo cALND where the SLN contains isolated tumour cells or micrometastasis. (ox.ac.uk)

thus, tumors with a high cell turnover are most susceptible (certain leukemias and lymphomas, small proliferating tumors, "recruited" tumor cells, and micrometastases). (doctorlib.info)

We included all patients with cutaneous melanoma that underwent SLN biopsy between 2002 and 2012 at Complejo Hospitalario de Navarra (Spain). (bvsalud.org)
Between 2002 and 2012, there were 348 patients who underwent SLN biopsy in our centre (308 were eligible for the study). (bvsalud.org)
A benign neoplasm cannot be distinguished from a malignant neoplasm on the basis of cytologic analysis of a fine-needle aspiration (FNA) biopsy specimen. (medscape.com)
The aim of this study was to evaluate the role of ICG guided SLN biopsy in Indian colon cancer patients. (turkjsurg.com)
Previous published studies have elucidated the role of SLN biopsy in Caucasian and East Asian patients ( 6 , 10 ). (turkjsurg.com)
Biopsy proven colon cancer patients with age at least 18 years old who were scheduled for elective laparoscopic/open colectomy were recruited. (turkjsurg.com)
PSA testing not only helps identify men in whom a prostate biopsy would be appropriate but also assists in assessing the response to therapy, determining tumor progression, and, in its most controversial role, screening for prostate cancer. (medscape.com)

Neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence. (medscape.com)
Clear cell type renal cell carcinoma is a malignant tumor that can metastasize to many locations, but unusually spreads to thyroid. (scirp.org)
The anatomopathological analysis of the surgical specimen described micrometastasis by clear cell renal carcinoma. (scirp.org)
Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)
Nasopharyngeal carcinoma (NPC) is a rare disease and one of the most common types of malignancies that appear in the nasopharynx, which is the narrow tube passage behind the nasal cavity and one of the malignancies associated with the Epstein-Barr virus (EBV) and is considered one of the malignant and rare tumors in most parts of the world and is distinguished by distribution geographical and ethnic [ 1 ]. (intechopen.com)
The aim of this study was to evaluate the potential of vascular cell adhesion molecule 1 (VCAM-1)-targeted MRI for early detection of brain micrometastases in mouse models across multiple primary tumor types.Experimental Design: Xenograft models of brain micrometastasis for human breast carcinoma (MDA231Br-GFP), lung adenocarcinoma (SEBTA-001), and melanoma (H1_DL2) were established via intracardiac injection in mice. (ox.ac.uk)
Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)
[ 5 ] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)
Surgical excision is the main treatment for patients with Hürthle cell carcinoma. (medscape.com)
thus, radioactive iodide treatment, which is the most useful nonsurgical therapy for recurrent well-differentiated thyroid carcinoma, is not always useful in patients with Hürthle cell carcinoma. (medscape.com)
Jillard et al reported that post-thyroidectomy 131 I therapy improves survival in patients with Hürthle cell carcinoma. (medscape.com)
[ 35 , 36 ] Retinoic acid therapy also may be considered in patients with Hürthle cell carcinoma that does not take up radioactive iodide, although this is not yet a standard form of therapy. (medscape.com)
therefore, T4 should be administered to all patients with thyroid carcinoma, regardless of the extent of thyroid surgery and other treatments. (medscape.com)
Hürthle cell carcinoma is considered a radiosensitive tumor. (medscape.com)
Indications for pancreatoduodenectomy in patients undergoing lymphadenectomy for advanced gallbladder carcinoma. (cancercentrum.se)
This is a current review on the circulating tumour cells (CTC) in patients with renal cell carcinoma as a potential diagnostic tool that will allow for more accurate assessment of advanced disease and the monitoring of treatment effects. (czytelniamedyczna.pl)

BACKGROUND: The addition of dendritic cell vaccines (DCV) to NAC could induce immune responses in those patients with residual disease (RD) by transforming the tumor microenvironment. (bvsalud.org)

The prognosis for patients with completely resected localized disease is excellent. (medscape.com)
As with other imaging modalities, MRI is unable to detect micrometastases and cannot definitively determine prognosis. (medscape.com)
In addition to 8th AJCC stage, vascular invasion and PLM, increasing tumor size and advanced T stage were also closely associated with the poor prognosis in 131 cases of pbt cancer patients compared with Ph cancer patients. (researchsquare.com)
The poor prognosis of PC is mainly due to the late diagnosis and advanced progression, most patients with PC are diagnosed at stages III and IV [5]. (researchsquare.com)
The prognosis is much better for skin hemangiosarcoma, with a stage 1 tumor having a median survival time of about 26 months. (dogcancer.com)

[ 126 ] In one retroactive study, survival of patients with sigmoid colon was only 33% while 99% of those with appendiceal tumor had survived. (medscape.com)
We examined the prognostic role of tumor burden in SLN on melanoma specific-survival and competing causes of death. (bvsalud.org)
Survival rates significantly differ between NPC patients according to stages of disease. (intechopen.com)
Survival rates of ulcerated tumors are proportionately lower than non-ulcerated melanoma of equivalent T category but are similar to patients with a non-ulcerated melanoma of the subsequent T category. (amegroups.org)
As a target, antiangiogenic therapy may therefore be potentially able to prolong survival time of patients with gastric cancer. (elsevierpure.com)
Likewise, knockdown of PGC1α significantly extended the survival of mice challenged by intracranial injection of melanoma cell lines but had no effect on subcutaneous tumor growth. (tmc.edu)
The 5-year survival rate of Stage IV patients is only 1% [ 6 ]. (medsci.org)
After 6 months of additional follow-up, patients with resected high-risk stage II melanoma continued to experience improved relapse-free survival following treatment with adjuvant pembrolizumab. (oncnursingnews.com)
Sintilimab, a bevacizumab biosimilar injection, met the primary end point of the phase 3 ORIENT-31 trial by significantly increasing progression-free survival in patients with EGFR-mutated, nonsquamous, non-small cell lung cancer. (oncnursingnews.com)
Engaging a multidisciplinary team at one of these centers helps ensure that the patient receives treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life. (radiationoncologyassociates.co)

88 patients died during the follow-up period and 66 (75%) died from melanoma. (bvsalud.org)
The cumulative probability of death from melanoma was associated with gender, histological subtype, Breslow thickness, mitotic rate, ulceration and SLN tumor burden. (bvsalud.org)
More prospective studies would be necessary to analyze these variables and to be able to make recommendations in management of melanoma patients. (bvsalud.org)
In 2014, it is estimated that 76,100 patients will be diagnosed with melanoma in the US, and about 9,710 will die from this disease ( 1 ). (amegroups.org)
Pembrolizumab has been approved for the adjuvant treatment of adults and pediatric patients with stage IIB or IIC melanoma who have underwent complete resection. (oncnursingnews.com)

Recent clinical and experimental studies have indicated that cellular and molecular mechanisms associated with liver regeneration after partial hepatectomy may have a proliferative effect on occult micrometastases and circulating tumor cells and are thus responsible for recurrent disease. (nih.gov)

Giant cell tumor is a benign bone tumor, locally aggressive with low malignant potential. (jbstjournal.com)
Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. (bookbaz.ir)

Gestational trophoblastic tumors are sensitive to many antineoplastic agents, especially those that act in the S phase or the M phase of the cell cycle. (medscape.com)

Ominoe G, Kodish E, Herman R. Neuroendocrine tumors of the appendix in adolescents and young adults. (medscape.com)
de Lambert G, Lardy H, Martelli H, Orbach D, Gauthier F, Guérin F. Surgical Management of Neuroendocrine Tumors of the Appendix in Children and Adolescents: A Retrospective French Multicenter Study of 114 Cases. (medscape.com)
Patients with neuroendocrine tumors across various origins experienced favorable responses after receiving tidutamab. (oncnursingnews.com)

A forest plot for RFS for dabrafenib and trametinib versus placebo looking at virtually every prognostic factor (eg, gender, age, macrometastases, micrometastases, ulceration, tumor burden, substage) found that the HRs did not overlap 1, and they were all in favor of dabrafenib and trametinib. (medscape.com)
RESULTS: Of 155 patients, 115 (74%) had macrometastases and 40 (26%) micrometastases in the SLNs. (ox.ac.uk)
Residual axillary disease was detected in 55/155 (35%) patients with macrometastases and 4/40 (10%) with micrometastases. (ox.ac.uk)

Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)

It has replaced the Clark level of invasion as a complementary criterion to ulceration for differentiating T1a versus T1b primary tumor ( 2 ). (amegroups.org)

Because only a fraction of the cells in a tumor die with each treatment (fractional kill), repeated doses must be administered to continue to reduce the size of the tumor. (worldsbest.rehab)

Inguinofemoral radiotherapy may be a safe alternative for patients with vulvar cancer and sentinel node micrometastases who might otherwise face the morbidity of a lymphadenectomy. (oncnursingnews.com)

In primary cultures of mouse embryonic day 14 (E14) striatum, maintained in vitro for 24 hr, 12% of the cells responded to FGF-2, whereas no response to EGF could be detected. (beauty104.com.tw)
Both tumor cells and host cells secrete a variety of factors to stimulate angiogenesis. (elsevierpure.com)
Breast cancer refers to several types of neoplasm arising from breast tissue, the most common being adenocarcinoma of the cells lining the terminal duct lobular unit. (capsulehealth.one)
Hemangiosarcoma, often abbreviated HSA or hemangio, are tumors thought to arise from vascular endothelial cells. (dogcancer.com)
As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
The first published report of circulating tumour cells dates back to 1869 (2). (czytelniamedyczna.pl)
As a result of changes in their adhesion molecules, the cells separate from the primary cell population and gain the ability to migrate independently within the extracellular matrix and, eventually, outside it (7). (czytelniamedyczna.pl)
The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune response, which is intended to target HER-2-expressing tumor cells, and may induce tumor regression or slow progression of disease. (stanford.edu)
The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. (stanford.edu)
To identify early driver mutations in ovarian cancer cells, we used dense whole genome sequencing of micrometastases and microscopic residual disease collected at three time points over three years from a single patient during treatment for high-grade serous ovarian cancer (HGSOC). (ox.ac.uk)
The functional and clinical significance of the identified mutations was examined using a combination of population-based whole genome sequencing, targeted deep sequencing, multi-center analysis of protein expression, loss of function experiments in an in-vivo reporter assay and mammalian models, and gain of function experiments in primary cultured fallopian tube epithelial (FTE) cells. (ox.ac.uk)
Tumor initiation is the process by which normal cells are changed so that they are able to form tumors. (doctorlib.info)
The killing of tumor cells follows first-order kinetics. (doctorlib.info)
Micrometastases are cancer cells that have spread beyond the area of the original cancer. (radiationoncologyassociates.co)

The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)

Liver resection is currently considered to be essential part of the curative treatment of primary and secondary liver malignancies. (nih.gov)
However, the underlying mechanisms explaining the interactions between regenerating liver tissue and tumour cell proliferation remain unclear. (nih.gov)
The most common locations for primary hemangiosarcoma include the spleen, the right atrium of the heart, the liver, and subcutaneous (under the skin) tissues. (dogcancer.com)
The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)
Tumors or cancer of the LIVER. (lookformedical.com)

The small molecule oral immunomodulator EC-18 reduced the duration and incidence of severe oral mucositis in patients with head and neck cancer undergoing concurrent chemoradiation. (oncnursingnews.com)

P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)

Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach. (utah.edu)

A retrospective study of a small number of female patients performed by Gourtsoyianni et al (2011) found that MRI was accurate in the evaluation of tumor extension in all patients after completion of chemoradiotherapy. (medscape.com)
Accurate evaluation of tumor stage is a prerequisite for further treatment and prognostic prediction. (researchsquare.com)

Also, the study will look at whether there are gene expression profiles in the tumor tissue that can predict pathologic complete response. (stanford.edu)
Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
Tumor promoters are not able to cause tumors to form, but increase the frequency of tumor formation in tissue previously exposed to the tumor initiator. (doctorlib.info)
Patients undergo a preoperative examination to determine whether it is possible to achieve wide surgical margins of healthy tissue, thereby avoiding amputation. (radiationoncologyassociates.co)

SLN tumor burden appears to be an important prognostic factor. (bvsalud.org)

MRI is being used increasingly in determining the extent of local invasiveness of urethral neoplasms for accurate staging and preoperative planning. (medscape.com)

The presence of micrometastasis in bone marrow was closely related to vascular endothelial growth factor positivity and microvessel density in the primary gastric cancer. (elsevierpure.com)
The goal of treatment of this tumor at the distal radius is complete removal of the tumor and reconstruction of the bone defect in order to preserve maximum function of the wrist joint. (jbstjournal.com)
Giant cell tumors (GCT) of the bone are aggressive and are recognised for variable clinical behaviour, which is not always related to radiographic or histological appearance [1]. (jbstjournal.com)
Campanacci's staging system for giant cell tumour of the bone [5] was used for cortical breach. (jbstjournal.com)
The multi-modality approach to treatment for osteosarcoma requires that patients be treated by a multi-disciplinary team consisting of the primary care physician, an orthopedic surgeon experienced in bone tumors, a pathologist, radiation oncologists, pediatric oncologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others. (radiationoncologyassociates.co)

Besides, in 70% of CRC cases, it develops from previous neoplasms, such as colorectal bowel adenomatous polyps [ 3 ] . (encyclopedia.pub)

The latter displays a higher frequency of WHO grade 3 tumors and poorer clinical outcomes. (bvsalud.org)
CONCLUSIONS: VCAM-1-targeted MRI enables the detection of brain micrometastases from the three primary tumor types known to cause the majority of clinical cases. (ox.ac.uk)
However, the results remain controversial and the relationship between tumor location and clinical characters is rarely reported. (researchsquare.com)
Recently, the long-term outcomes of prospective randomized clinical trials provide new hope for organ preservation in patients with ERC. (pfmjournal.org)

In multivariable analysis, Breslow thickness and SLN tumor burden remained as independent prognostic factors. (bvsalud.org)
METHODS: Patients who underwent cALND following a positive SLN were analysed for histopathological features of the primary tumour and burden of axillary disease. (ox.ac.uk)

AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma: By the AFC-IHCC-2009 study group. (cancercentrum.se)

Once the patient was fit for Surgery, wide excision of tumor and reconstruction with ipsilateral non-vascularised proximal fibula was performed. (jbstjournal.com)
Juxta-articular giant cell tumors of the lower end radius are common and present a special problem of reconstruction after tumor excision. (jbstjournal.com)
Complete excision of the tumor offers the best chance of cure but sacrifices the articular surface and presents complex reconstructive problems. (jbstjournal.com)

Materials and Methods Twenty-five patients with confirmed fine needle aspiration cytological diagnosis of breast cancer, who were undergoing planned mastectomy and axillary node clearance, were included in the study. (bvsalud.org)
All patients underwent mastectomy and Level II axillary clearance. (bvsalud.org)
Conclusions In our setting, SLNB using methylene blue dye is also an effective method for accurately identifying SLNs in breast cancer patients and provide an accurate pathological staging without having to do a formal axillary clearance. (bvsalud.org)

Carcinoid tumor of the common bile duct in children: a case report. (medscape.com)
Fourteen-year-old girl with endobronchial carcinoid tumour presenting with asthma and lobar emphysema. (medscape.com)
Murali R, Kneale K, Lalak N, Delprado W. Carcinoid tumors of the urinary tract and prostate. (medscape.com)
Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)

In September 2015 the patient underwent total right laparoscopic nephrectomy and pathological anatomy offered the diagnosis of CCRC pT3 N0 M1. (scirp.org)
After assessing clinic, size increase and the oncologic background, the patient underwent a total thyroidectomy in May 2016. (scirp.org)
Forty-eight patients of clinically staged T1-T3 node negative colon cancer underwent laparoscopic/open resection. (turkjsurg.com)
Importantly, we show that SOX2 overexpression in FTE is nearly ubiquitous in patients with HGSOCs (n=100), and common in BRCA1-BRCA2 mutation carriers (n=71) who underwent prophylactic salpingo-oophorectomy. (ox.ac.uk)
Of the 29 cases of TSCC at stage I/II that were treated between 2008 and 2017 at Kanazawa University Hospital's Department of Oral and Maxillofacial Surgery, we retrospectively analyzed the cases of the 25 patients who underwent surgery at the primary site as their initial treatment. (biomedcentral.com)
Researchers at MD Anderson Cancer Center evaluated 31 pediatric patients who initially underwent treatment with intent-to-cure utilizing chemotherapy alone. (radiationoncologyassociates.co)

[ 122 ] Second primary malignancies of gastrointestinal tract which occurred in up to 33% of cases in adults,are unusual in children and adolescents. (medscape.com)

All patients presented with pain and swelling over distal end radius and were assessed clinically and radiographically. (jbstjournal.com)

The purpose of our study was to develop modern epidemiological data for adult patients completing an appendectomy for UA secondary to an appendiceal neoplasm (AN). (cancerindex.org)

Treatment varies according to the type and stage of tumour. (cancerindex.org)
No thyroid hormone treatment is administered to the patient in the interim. (medscape.com)
If the patient is hospitalized for 131 I treatment, administer antiemetics and adequate hydration. (medscape.com)
The novel nomogram will assist in patient counseling and guide treatment decision making for T1 and T2 GBC patients. (medsci.org)
Brexucabtagene autoleucel is now an FDA approved treatment options for adult patients with relapsed/refractory B-cell precursor acute lymphoblastic leukemia. (oncnursingnews.com)
However, some drugs have a better side-effect profile than others, enabling doctors to adjust treatment regimens to the advantage of patients in certain situations. (wikidoc.org)
The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
We retrospectively analyzed the cases of 25 patients with stage I/II TSCC who had undergone surgical treatment without elective neck dissection. (biomedcentral.com)
Circumstances unique to each patient's situation may influence how these general treatment principles are applied and whether the patient decides to receive treatment. (radiationoncologyassociates.co)
The information on this website is intended to help educate patients about their treatment options and to facilitate a mutual or shared decision-making process with their treating cancer physician. (radiationoncologyassociates.co)
The primary cooperative group evaluating osteosarcoma treatment in the US is the Children's Cancer Study Group. (radiationoncologyassociates.co)
1 After 3 months of treatment, the second phase of the study began in which patients received more chemotherapy instead of surgery. (radiationoncologyassociates.co)
In order to apply these treatment strategies in a patient-specific manner, it is important to establish sophisticated indications that can maximize the therapeutic effect. (pfmjournal.org)

The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)

Eighteen patients had node positive disease, and SLN was false negative in four of these patients resulting in a sensitivity of 77.77% with a trend towards higher sensitivity for T1-T2 tumours (90% vs. 62.5%, p= 0.068). (turkjsurg.com)

METHODS: Core diagnostic biopsies and surgical specimens from 80 patients (38 in the vaccinated group plus NAC (VG) and 42 in the control group (CG, treated only with NAC) were selected. (bvsalud.org)
Methods: 351 patients with curatively resected pancreatic adenocarcinoma (PC) from three center hospitals were entered into this multicenter cohort study. (researchsquare.com)
Materials and Methods: From November 2008 to April 2009, consecutive patients presenting to the Accident & Emergency department or the surgical wards with right iliac fossa pain were recruited for the study. (bvsalud.org)
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)

However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)

A patient-based advocacy organization, founded in 2004, dedicated to serving the needs of those diagnosed with cancer of the appendix. (cancerindex.org)
Despite these drawbacks, MRI is being used increasingly for the staging of urethral cancer and is typically the imaging modality of choice in the evaluation of patients with urethral cancer. (medscape.com)
Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer. (utah.edu)
All patients enrolled from the First hospital of China Medical University, Shengjing hospital of China Medical University and Cancer hospital of China Medical University were histologically proven to be pancreatic ductal adenocarcinomas. (researchsquare.com)
stage of cancer in which the disease has spread from the primary site to other parts of the body. (thewomenofhope.org)
an organization that supports research, educational materials and programs, and offers many other services to cancer patients and their families. (thewomenofhope.org)
Deriving from a comprehensive analysis of CTC transcriptomes, we discovered a unique "circulating tumor cell gene signature" that is distinct from primary breast cancer tissues. (houstonmethodist.org)
Colon cancer patients who met the eligibility criteria were enrolled from June, 2020 to June, 2022. (turkjsurg.com)
CTCs are suspected of being instrumental for dissemination of the cancer during surgery, which involves mechanical manipulation and traumatisation of the primary tumour (5). (czytelniamedyczna.pl)
Tumors or cancer of the PANCREAS. (lookformedical.com)
Tumors or cancer of the SKIN. (lookformedical.com)
Tumors or cancer of the LUNG. (lookformedical.com)
Tumors or cancer of the THYROID GLAND. (lookformedical.com)
Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. (ox.ac.uk)
2(-16)), which was not found in patients without cancer (n=108). (ox.ac.uk)
Substances that cause cancer can be tumor initiators. (doctorlib.info)
The two main types of genes that are now recognized as playing a role in cancer are oncogenes and tumor suppressor genes. (doctorlib.info)
An experienced team is best found in specialty cancer centers that treat many patients with osteosarcoma. (radiationoncologyassociates.co)
The specific type of surgery a patient undergoes depends on the location and extent of the cancer. (radiationoncologyassociates.co)
Overall, 48% of patients survived, 23% were cancer free. (radiationoncologyassociates.co)
This can include very small tumors of less than 1 millimeter (microinvasive breast cancer). (lbbc.org)
however, most urologists would testify that they see far fewer patients with advanced prostate cancer since the PSA era began. (medscape.com)
Urologists obtain PSA measurements for most of their male patients in the appropriate age group because they believe they have an obligation to detect any prostate cancer at the earliest possible stage of its development. (medscape.com)

Cytology of yolk sac tumor in ascitic fluid. (hunimed.eu)

Malignant germ cell tumors of the ovary: a study of 20 cases. (medscape.com)
and human chorionic gonadotropin (hCG), seen in choriocarcinoma testicular germ cell neoplasms. (doctorlib.info)

We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
Once the patient was medically fit, surgery (ORIF with resection of distal end of radius and reconstruction with ipsilateral non vascularised proximal fibula along with plate and 2 k-wires) was performed. (jbstjournal.com)

Anatomy4

Organisms1

Diseases27

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes2

Disciplines and Occupations1

Information Science1

Health Care5

Metastasis37

Metastases18

Metastatic15

Recurrence7

Cancers12

Lymph15

Isolated tumour cells1

Small prolif1

Biopsy7

Carcinoma16

Microenvironment1

Prognosis5

Survival10

Melanoma5

Circulating tumor cells1

Benign2

Antineoplastic agents1

Neuroendocrine Tumors3

Macrometastases3

Malignant tumors2

Ulceration1

Size of the tumor1

Sentinel1

Cells16

Staging laparoscopy1

Liver5

Incidence1

Suppressor Gene1

Biomarkers1

Evaluation of tumor2

Tissue4

Prognostic factor1

Invasiveness1

Bone5

Colorectal1

Clinical4

Burden2

Outcomes1

Excision3

Axillary3

Carcinoid4

Underwent6

Malignancies1

Clinically1

Appendiceal1

Treatment13

Adjuvant1

Tumours1

METHODS4

Immunotherapy1

Cancer23

Yolk1

Germ2

Resection2