TransplantImmunotherapyMultiple myelomaLymphomaDonorPeripheral blood stemRegimenMorbidity and mortaSystemicRadiation therapyMalignanciesAcuteCyclophosphamideInfectionTherapyRadiotherapy and chemotherapyTransplantsSurvivalRefractory diseaseAdultRelapseTumorDiagnosisIntensiveRecipientsMarrowHSCTDonorsMyeloidMalignantLeukemiaClinicalRemissionVersusPlateletsCommonlyDosesInfectionsInductionToxicityTherapies are oftenProcedureProliferationApheresisComplicationsBlood stem cellsMediastinal
Transplant36
- A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
- When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
- When the stem cells are collected from the blood, after stimulating the stem cells with a hormone called G-CSF, the transplant is called a peripheral blood stem cell transplant. (ucsfhealth.org)
- Currently, most transplant procedures involve collecting stem cells from the peripheral blood. (ucsfhealth.org)
- Allogeneic transplants are significantly more dangerous and require more intensive follow-up after the transplant procedure. (ucsfhealth.org)
- Remissions may be brought about with steroids, chemotherapy, targeted therapy, and stem cell transplant. (wikipedia.org)
- Arvin AM . Varicella-zoster virus: pathogenesis, immunity, and clinical management in hematopoietic cell transplant recipients. (nature.com)
- 1 Significant advances have been made by combining novel agents with autologous peripheral blood stem cell transplantation which allows for long-term disease-free survival in the majority of transplant-eligible patients. (haematologica.org)
- Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
- This trial uses a combination of high dose chemotherapy with stem cell transplant using the patient's own cells. (stanford.edu)
- This is followed with non-myeloablative transplant using stem cells from a related or unrelated donor to try and generate an anti-lymphoma response from the new immune system. (stanford.edu)
- 40% prior to the allogeneic transplant. (stanford.edu)
- In this type of transplant, the patient's own stem cells are collected before the high-dose chemotherapy and/or radiation therapy is given. (vanyahealth.com)
- This type of transplant is used when the patient's own cells are not damaged or diseased, but are being used as a rescue therapy after high-dose chemotherapy or radiation therapy. (vanyahealth.com)
- In this type of transplant, stem cells are taken from a donor (usually a close relative or sibling) and given to the patient. (vanyahealth.com)
- This type of transplant is used when the patient's own cells are damaged or diseased. (vanyahealth.com)
- Haploidentical transplant, also known as half-matched transplant, is a type of allogeneic transplant where the donor and the recipient are not a perfect match but share one haplotype (half of the genetic material) in common. (vanyahealth.com)
- The donor's cells are not as well matched to the patient's cells as in a standard allogeneic transplant, which increases the risk of complications such as graft-versus-host disease (GVHD) and graft rejection. (vanyahealth.com)
- Cord blood transplant is a type of allogeneic transplant that uses stem cells from the umbilical cord of a newborn baby. (vanyahealth.com)
- The main advantage is that cord blood cells are less mature than adult stem cells, which makes it less likely for the patient's immune system to reject the transplant. (vanyahealth.com)
- However, cord blood units often have fewer stem cells than a bone marrow or peripheral blood transplant, which can increase the time it takes for the patient's blood counts to recover. (vanyahealth.com)
- Both haploidentical BMT and cord blood transplant are considered alternative options for patients who do not have a suitable matched donor. (vanyahealth.com)
- This occurs when the donated cells attack the patient's own cells in case of allogeneic transplant. (vanyahealth.com)
- Patients who have had a bone marrow transplant are at an increased risk of infections due to the suppression of their immune system. (vanyahealth.com)
- An allogeneic transplant uses someone else's stem cells. (medlineplus.gov)
- Currently, only stem cell transplant utilizing cells from a donor-called an allogeneic transplant-can consistently cure patients with MDS. (hoapb.com)
- In addition to this innovation, a specific programme has been set up to facilitate this autologous transplant for people living outside Madrid . (mdanderson.es)
- While in an autologous transplant there is no donor and the patient is the focus of the whole process, in an allogeneic transplant there is a donor and therefore compatibility studies must be carried out before starting the process ," explains the doctor. (mdanderson.es)
- For its part, an allogeneic transplant does not focus its curative intention on chemotherapy but on the contrary: here, chemotherapy serves to prepare the patient who will receive the cells from a donor and to help him/her nest these cells properly . (mdanderson.es)
- The research team is working to reduce treatment toxicity and improve patient outcomes using leading-edge research to advance hematopoietic stem cell transplant methods. (lovesorghum.com)
- The team has access to a large transplant patient population, rich historical data and a clinical department with a reputation for outstanding transplant outcomes for the past 12 consecutirve years. (lovesorghum.com)
- p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
- some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- Note: For transplant-eligible patients enrolled to Part 1 or Part 2, induction plus conditioning chemotherapy/ASCT +/- maintenance therapy constitute one regimen. (who.int)
Immunotherapy6
- Most important aspect of therapy is anti CD20 antibody, the Rituximab, which is a kind of immunotherapy or targeted therapy and attacks the CD20 antigen on the cancer cells. (lymphomaindia.com)
- Multiagent chemotherapy + immunotherapy should be reserved for patients who are having advanced stages of disease and having symptoms/ difficulties related to it. (lymphomaindia.com)
- 1 , 7 Consensus guidelines in this difficult-to-treat population are challenging to create given the small numbers of patients and multiple treatment options in this era of burgeoning cellular and immunotherapy. (jnccn.org)
- Treatment is curative in most cases and consists of chemotherapy with or without other treatment modalities, including antibody-drug conjugates, immunotherapy, and radiation therapy. (msdmanuals.com)
- Involving the direct use of whole cells or cellular material in patients, cell therapy is an umbrella term for many subdivisions of biological research, encompassing fields such as stem cell therapy, gene therapy and immunotherapy. (ddw-online.com)
- The cross-talk of cancer-associated fibroblasts assist in prognosis and immunotherapy in patients with breast carcinoma. (cdc.gov)
Multiple myeloma14
- Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood cell that normally produces antibodies. (wikipedia.org)
- Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibody proteins - (often using electrophoretic techniques revealing the presence of a monoclonal spike in the results - termed an m-spike), bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)
- Multiple myeloma (MM) is a malignant plasma cell disorder with debilitating symptoms related to anemia, immunosuppression, bone destruction, and renal failure. (haematologica.org)
- Background: The mainstay of therapy for newly diagnosed multiple myeloma patients remains systemic chemotherapy. (drugpatentwatch.com)
- Donor immunization with myeloma Id in the setting of a non-myeloablative allogeneic SCT may represent a novel strategy for the treatment of multiple myeloma. (drugpatentwatch.com)
- To determine the efficacy of a novel conventional chemotherapy regimen (Fludarabine-EPOCH) in the setting multiple myeloma. (drugpatentwatch.com)
- To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- This procedure is typically used to treat blood cancers such as leukemia, lymphoma, and multiple myeloma, as well as other disorders such as sickle cell anemia and thalassemia. (vanyahealth.com)
- Multiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. (medlineplus.gov)
- In people with multiple myeloma, abnormal plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. (medlineplus.gov)
- Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - health professional version. (medlineplus.gov)
- In addition to systemic treatments and/or targeted therapies, both autologous and allogeneic haematological progenitor transplantation (commonly called bone marrow transplantation) continues today to be part of the treatment plan for many patients with various haematological diagnoses such as leukaemia, lymphoma and multiple myeloma . (mdanderson.es)
Lymphoma21
- Lymphoma was initially treated with chemotherapy, but relapse required autologous peripheral stem cell transplantation in July 2005. (cdc.gov)
- The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
- Diffuse large B-cell lymphoma (DLBCL) is the most common form of NHL, accounting for more than 30 percent of newly diagnosed cases. (lymphomaindia.com)
- Another example is "primary mediastinal B-cell lymphoma" which often occurs in younger patients and grows rapidly in the chest (mediastinum) Often, the first sign of DLBCL is a painless rapid swelling in the neck, armpit, or groin, which is caused by enlarged lymph nodes. (lymphomaindia.com)
- Most patients with DLBCL are adults, although this lymphoma is sometimes seen in children. (lymphomaindia.com)
- Follicular lymphoma (FL), a B-cell lymphoma, is the most common indolent (slow-growing) form of NHL, accounting for approximately 20 percent to 30 percent of all NHLs. (lymphomaindia.com)
- Approximately 30-40 % of patients with FL will eventually transform to a more aggressive form of lymphoma like Diffuse Large B Cell Lymphoma and may require intensive chemotherapy followed by autologous stem cell transplantation. (lymphomaindia.com)
- Therapy of lymphoblastic lymphoma (LL) has evolved with use of chemotherapy regimens modeled after those for acute lymphocytic leukemia (ALL). (ashpublications.org)
- Hodgkin lymphoma (HL) is a unique hematopoietic neoplasm characterized by cancerous Reed-Sternberg cells in an inflammatory background. (johnshopkins.edu)
- Adult T-cell leukemia/lymphoma (ATLL) is a rare and aggressive disease caused by human T-cell lymphotropic virus type 1 that predominantly affects Japanese and Caribbean populations. (oncotarget.com)
- Adult T-cell leukemia/lymphoma (ATLL) is a rare mature T-cell malignancy first described in Japan in 1977 [ 1 ]. (oncotarget.com)
- The purpose of this trial is to develop an alternative treatment for patients with poor risk non-Hodgkin's lymphoma. (stanford.edu)
- Although children, adolescents, and young adults with newly diagnosed B-cell non-Hodgkin's lymphoma enjoy excellent overall survival with current chemoimmunotherapy, those with relapsed and/or refractory disease have a dismal prognosis. (jnccn.org)
- Children, adolescents, and young adults (CAYAs) with newly diagnosed B-cell non-Hodgkin's lymphoma (B-NHL) enjoy excellent overall survival (OS) with current frontline chemoimmunotherapy. (jnccn.org)
- Kaplan-Meier curve showing probability of overall survival in children and adolescents with mature B-cell non‐Hodgkin's lymphoma with refractory or relapsed disease during or after therapy in the FAB/LMB96 international study. (jnccn.org)
- Overall survival of children and adolescents with mature B cell non-Hodgkin lymphoma who had refractory or relapsed disease during or after treatment with FAB/LMB 96: a report from the FAB/LMB 96 study group. (jnccn.org)
- Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
- Hodgkin lymphoma results from the clonal transformation of cells of B-cell origin, giving rise to pathognomic binucleated Reed-Sternberg cells. (msdmanuals.com)
- Most patients with Hodgkin lymphoma present with painless cervical adenopathy. (msdmanuals.com)
- Newly diagnosed lymphoma patients are required to undergo a number of tests and procedures to ensure accurate diagnosis and staging. (hoapb.com)
- If properly performed, a bone marrow biopsy should not cause patients significant pain and should provide useful information for the appropriate management of lymphoma. (hoapb.com)
Donor11
- For allogeneic transplantation, the patient receives bone marrow or stem cells from a donor who may or may not be a relative. (ucsfhealth.org)
- Application prospect of low-dose porcine anti-thymocyte globulin in HLA-matched sibling donor transplantation. (stembook.org)
- Hematopoietic stem cell transplantation from an infected SARS-CoV2 haploidentical donor: A case report. (stembook.org)
- To determine whether antigen-specific immunity, induced in the stem cell donor, can be passively transferred to the allogeneic SCT recipient in the setting of a non-myeloablative conditioning regimen. (drugpatentwatch.com)
- Alternate donor sources and reduced-intensity conditioning have made allogeneic hematopoietic stem cell transplantation a viable option for more patients. (johnshopkins.edu)
- No contra-indication for the donor to collection by apheresis of mononuclear cells mobilized by G-CSF at a dose of 16 µg/kg of body weight. (stanford.edu)
- Cord blood transplants are an alternative to using stem cells from a matched adult donor. (vanyahealth.com)
- The cells used in transplantation can either be derived from an individual patient (autologous cell therapy) or from another donor (allogeneic cell therapy). (ddw-online.com)
- It is these donor cells that, once infused into the patient, will populate the bone marrow and rebuild the immune system, which is called the graft-versus-disease effect ," highlights this specialist. (mdanderson.es)
- The high doses of therapy lead to destruction of patient's marrow and immune system, which is then replaced by healthy marrow from self (autologous) or donor (allogeneic) hematopoietic stem cells that have been harvested from bone marrow or peripheral blood before therapy. (lovesorghum.com)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Peripheral blood stem2
- Citation: Mera T, Heimfeld S, Faustman DL (2014) The Spleen Contributes Stem Cells to Peripheral Blood Stem Cell Transplants. (fliphtml5.com)
- TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
Regimen7
- Determine the toxic effects of this regimen in these patients. (knowcancer.com)
- Determine whether this regimen can induce cell apoptosis in these patients. (knowcancer.com)
- Efficacy of venetoclax combined with decitabine conditioning regimen for allogeneic hematopoietic stem cell transplantation in high-risk and elderly patients with myeloid neoplasms. (stembook.org)
- Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)
- Although the same doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapeutic regimen has been the mainstay of therapy over the last 30 years, risk-adapted approaches have helped de-escalate therapy in low-risk patients while intensifying treatment for higher risk patients. (johnshopkins.edu)
- Patients must have received at least one prior chemotherapy regimen for their acute myeloid leukemia (AML) and they may have received any type of chemotherapy. (stanford.edu)
- A chemotherapy regimen typically consists of a specific number of cycles over a set period. (zenonco.io)
Morbidity and morta1
- 1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)
Systemic4
- Patients are commonly diagnosed with HL in their 20s and 30s, and they present with supradiaphragmatic lymphadenopathy, often with systemic B symptoms. (johnshopkins.edu)
- INTRODUCTION - The initial evaluation of a patient with suspected thrombotic thrombocytopenic purpura (TTP) or another primary thrombotic microangiopathy (TMA) syndrome must focus on distinguishing these primary syndromes from other systemic disorders that can present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. (medilib.ir)
- Other systemic disorders that can present with MAHA and thrombocytopenia include pregnancy-associated syndromes (eg, preeclampsia with severe features and HELLP syndrome), severe hypertension, systemic infections and malignancies, autoimmune disorders such as systemic lupus erythematosus, and complications of hematopoietic stem cell or solid organ transplantation. (medilib.ir)
- Systemic chemotherapy gets into the bloodstream to reach cancer cells in the body. (zenonco.io)
Radiation therapy7
- In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
- Radiation therapy is good enough for a patient who is having an early stage disease/ localized disease (stage-1) and having some symptoms because of it. (lymphomaindia.com)
- Consolidative radiation therapy was given to patients with mediastinal disease at presentation. (ashpublications.org)
- The common treatment for Ewing sarcoma involves chemotherapy, surgery, radiation therapy, and stem cell transplantation or bone marrow transplantation. (zenonco.io)
- Radiation therapy uses high-energy X-rays to kill cancer cells. (zenonco.io)
- After this first chemotherapy is finished, the doctor can use localized surgery or radiation therapy followed by more chemotherapy to eliminate any remaining cancer cells. (zenonco.io)
- After the chemotherapy and radiation therapy, the stored stem cells are thawed and returned to the patient's body. (vanyahealth.com)
Malignancies6
- Determine the clinical effectiveness of bevacizumab, cytarabine, and mitoxantrone in patients with poor-risk hematologic malignancies. (knowcancer.com)
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
- Khouri IF , Fernandez Curbelo I, Turturro F , Jabbour EJ , Bassett RL, Vence LM, Allison JP , Gulbis AM, Sharma P , Milton DR. Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies. (viictr.org)
- Hematopoietic stem cell transplantation is a procedure that involves the infusion of stem cells to treat patient malignancies or to repair diseased or defective bone marrow. (lovesorghum.com)
- The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
Acute21
- Application of prophylactic or pre-emptive therapy after allogeneic transplantation for high-risk patients with t(8;21) acute myeloid leukemia. (stembook.org)
- The outcome of acute leukemia patients with SET-NUP214 fusion after allogeneic stem cell transplantation. (stembook.org)
- Refractory patients with favorable/intermediate-risk acute myeloid leukemia benefit from azacytidine maintenance therapy following allogeneic hematopoietic stem cell transplantation. (stembook.org)
- Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
- Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
- I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
- This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
- Patients with acute lymphoblastic leukemia (ALL) present with either symptoms relating to direct infiltration of the marrow or other organs by leukemic cells, or symptoms relating to the decreased production of normal marrow elements. (medscape.com)
- Although patients may present with symptoms of leukostasis (eg, respiratory distress, altered mental status) because of the presence of large numbers of lymphoblasts in the peripheral circulation, leukostasis is much less common in people with ALL than those with acute myelogenous leukemia (AML), and it occurs only in patients with the highest WBC counts (ie, several hundred thousand per μL). (medscape.com)
- Patients with acute lymphoblastic leukemia (ALL) commonly have physical signs of anemia, including pallor and a cardiac flow murmur. (medscape.com)
- In acute leukemia, cancer cells multiply quickly. (healthline.com)
- PURPOSE: This phase II trial is studying how well giving idarubicin and cytarabine together with pravastatin works in treating patients with relapsed acute myeloid leukemia (AML). (stanford.edu)
- ADDITIONAL BACKGROUND: S0919 was initially designed for patients with relapsed acute myeloid leukemia (AML), where the patient's preceding remission had lasted ≥ 3 months. (stanford.edu)
- Patients must have a previous morphologically confirmed diagnosis of acute myeloid leukemia (AML). (stanford.edu)
- Patients with acute promyelocytic leukemia (APL, FAB, M3) or blastic transformation of chronic myelogenous leukemia (CMML) are not eligible. (stanford.edu)
- INITIAL EVALUATION (ALL PATIENTS) - Individuals with a TMA may come to medical attention with any of a variety of presentations including unexplained anemia or thrombocytopenia, unexplained neurologic findings (suspected stroke or transient ischemic attack), or other acute illness. (medilib.ir)
- Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS. (hoapb.com)
- It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
- Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)
- The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
- Impact of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation. (cdc.gov)
Cyclophosphamide6
- Patients with uveitis who are not responding well to steroid treatment and patients who have side effects from other medicines used to treat uveitis (such as cyclosporine, cyclophosphamide, methotrexate or azathioprine) or have refused treatment because of possible side effects of these medicines may be eligible for this study. (drugpatentwatch.com)
- We treated 33 patients with LL with the intensive chemotherapy regimens hyper-CVAD (fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone) or modified hyper-CVAD used for ALL at our institution. (ashpublications.org)
- Herein we characterized human fetal bone marrow stromal cells (hBMSCs) during wound healing in mice treated with cyclophosphamide (CTX). (ijbs.com)
- Cyclophosphamide (CTX) is a common drug widely used in chemotherapy. (ijbs.com)
- Patients with known allergy to etoposide or a history of Grade 3 hemorrhagic cystitis with cyclophosphamide are not eligible. (stanford.edu)
- Conditioning with targeted busulfan and cyclophosphamide for hemopoietic stem cell transplantation from related and unrelated donors in patients with myelodysplastic syndrome. (hoapb.com)
Infection13
- Appropriate cultures, in particular blood cultures, should be obtained in patients with fever and in those with other signs of infection even if fever is absent. (medscape.com)
- A predictive model of varicella-zoster virus infection after autologous peripheral blood progenitory cell transplantation. (nature.com)
- Atkinson K, Meyers J, Storb R, Prentice RL, Thomas ED . Varicella-zoster virus infection after marrow transplantation for aplastic anemia or leukemia. (nature.com)
- Infection with varicella-zoster virus after marrow transplantation. (nature.com)
- Han CS, Miller W, Haake R, Weisdorf D . Varicella zoster infection after bone marrow transplantation: incidence, risk factors and complications. (nature.com)
- Varicella zoster virus infection associated with high-dose chemotherapy and autologous stem-cell rescue. (nature.com)
- Fever is one of the most common symptoms of ALL, and patients with ALL often have fever without any other evidence of infection. (medscape.com)
- Patients known to be human immunodeficiency virus (HIV)-positive are ineligible because the concern for opportunistic infection and hematologic reserve are considered to be significantly greater in this population. (stanford.edu)
- Patients with uncontrolled infection. (stanford.edu)
- White blood cells help the body fight infection. (zenonco.io)
- Human Immunodeficiency Virus (HIV) Infection Human immunodeficiency virus (HIV) infection results from 1 of 2 similar retroviruses (HIV-1 and HIV-2) that destroy CD4+ lymphocytes and impair cell-mediated immunity, increasing risk of certain. (msdmanuals.com)
- Plasma cells help your body fight infection by producing proteins called antibodies . (medlineplus.gov)
- p>Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). (nemours.org)
Therapy24
- Patients achieving partial or complete remission may receive a second course of therapy beginning approximately 30 days after the completion of the first course. (knowcancer.com)
- We also provide cancer pain therapy and psychooncological support for our patients and their relatives, as well as an explicit internal check-up. (uniklinikum-dresden.de)
- For Treatment we use different, state of the art therapy Options as Immune Therapy, Chemotherapy and the treatment with targeted therapies. (uniklinikum-dresden.de)
- Adult patients with mucoviscidosis receive comprehensive Treatment including the departments of Endocrinology, physical Therapy, gastroenterology, medical psychology, microbiology etc. (uniklinikum-dresden.de)
- New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
- Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
- A main challenge of NK cell therapy is that it requires a high amount of functional NK cells. (frontiersin.org)
- Induction consolidation was administered with 8 or 9 alternating cycles of chemotherapy over 5 to 6 months with intrathecal chemotherapy prophylaxis, followed by maintenance therapy. (ashpublications.org)
- Walking with patients through this journey from start to finish, and offering therapy and guidance along the way, is a source of professional and personal satisfaction for me. (rochester.edu)
- Even patients who are not cured with initial therapy can often be salvaged with alternate chemotherapy combinations, the novel antibody-drug conjugate brentuximab, or high-dose autologous or allogeneic hematopoietic stem cell transplantation. (johnshopkins.edu)
- This is the first analysis to describe ATLL pathological features, cytogenetics, and response to standard therapy and transplantation in the Caribbean cohort. (oncotarget.com)
- She has always worked in the area of oncology and, in addition to that, has worked with cell and gene therapy protocols for over 15 years. (bcm.edu)
- Although most clinicians would agree that hematopoietic progenitor cell transplantation after reinduction therapy is frontline therapy for these patients, there is no consensus as to what type of hematopoietic progenitor cell transplantation promises the best event-free and overall survival. (jnccn.org)
- This review outlines the disparate types of stem cell therapy that have been used in this difficult-to-treat population as well as the role of maintenance and CAR T-cell therapy in conjunction with stem cell therapy. (jnccn.org)
- 1 - 3 However, those with relapsed and/or refractory (R/R) disease have had a historically dismal OS of ≤30% despite reinduction therapy and autologous hematopoietic progenitor cell transplantation (autoHCT) ( Figure 1 ). (jnccn.org)
- HCT, whether it be autologous, allogeneic, or tandem, has been and continues to be an integral part of therapy, with varying outcomes as delineated in Table 2 . (jnccn.org)
- and the role of CAR T-cell therapy as it relates to HCT as therapies for R/R B-NHL. (jnccn.org)
- Cell therapy is poised to play a pivotal role in the development of precision and personalised medicines that will transform healthcare for millions of patients worldwide. (ddw-online.com)
- Immuno-oncology approaches have been found to be more effective at long-lasting tumour regression than alternatives such as surgery, radiotherapy, chemotherapy and targeted therapy (1,2). (ddw-online.com)
- This article discusses the challenges facing cell therapy research, and how the latest cell culture technologies are delivering enhanced safety capabilities, improved laboratory performance and, ultimately, optimised cell therapy processes. (ddw-online.com)
- Because of the huge potential for variability within treatments, an additional challenge in cell therapy is the need for robust manufacturing processes that consistently deliver safe and effective products. (ddw-online.com)
- Cell therapy manufacturing processes can range from the simple expansion of autologous cells that will be administered back to patients, to the complex genetic manipulation of allogeneic cells that could be stored and banked for the treatment of multiple patients. (ddw-online.com)
- In autologous transplantation the tool is chemotherapy, in allogeneic transplantation it is the new immune system and in CAR-T cell therapy it is the patient's own re-educated T-lymphocytes ," concludes this expert. (mdanderson.es)
- HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
Radiotherapy and chemotherapy1
- Further relapses in 2006 and 2007 were treated with radiotherapy and chemotherapy, respectively, before the patient underwent an allogeneic peripheral stem cell transplantation in July 2008. (cdc.gov)
Transplants4
- Identical twin allogeneic transplants are called syngeneic transplants. (ucsfhealth.org)
- Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
- For induce splenomegaly in most donors and in rare, severe cases splenicautologous stem cell transplants, the use of autologous PBSCT from rupture [13,14]. (fliphtml5.com)
- Firstly, precisely these haematopoietic progenitors are key in autologous and allogeneic transplants, but not in CAR-T therapies. (mdanderson.es)
Survival6
- The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases. (stembook.org)
- In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
- There was no difference in survival between patients who received chemotherapy alone versus chemotherapy with antiviral agents. (oncotarget.com)
- Recipients of allogeneic transplantation had significantly improved overall survival compared to non-transplanted patients. (oncotarget.com)
- Treatment is designed to manage the complications associated with ineffective blood cell production, extend survival, and cure the disease when possible. (hoapb.com)
- Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
Refractory disease2
- Allogeneic stem cell transplantation should be considered for refractory disease or for very early relapsing disease. (lymphomaindia.com)
- Allogeneic transplantation was performed in five patients, two of whom achieved complete remission despite residual or refractory disease. (oncotarget.com)
Adult4
- Outcomes of allogeneic or autologous stem cell transplantation followed by maintenance chemotherapy in adult patient with B-ALL in CR1 with no detectable minimal residual disease. (stembook.org)
- In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
- Physicians and scientists work side by side to set standards for stem cell transplantation and improve long-term outcomes for both pediatric and adult patients. (lovesorghum.com)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
Relapse5
- Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. (haematologica.org)
- Even with a reduction in treatment related mortality, success with allogeneic SCT is limited by a significant risk of relapse. (drugpatentwatch.com)
- Some patients may not respond to chemotherapy at all while few patients respond initially but later on relapse. (lymphomaindia.com)
- The patient who relapse or who does not respond to initial treatment, require more intensive treatment. (lymphomaindia.com)
- 1 , 2 , 4 - 6 Specifically, patients with lactate dehydrogenase ≥2 times the upper limit of normal (ULN) at diagnosis, R/R disease within 6 months of diagnosis, multisite relapse, and/or R/R disease with bone marrow involvement experience a significantly decreased OS ( Table 1 ). (jnccn.org)
Tumor2
- Patients with a high tumor burden, particularly those with severe hyperuricemia, can present in renal failure. (medscape.com)
- When possible, surgical removal of the tumor should happen after chemotherapy. (zenonco.io)
Diagnosis4
- The diagnosis and treatment facilities we offer our patients are of the highest standard. (uniklinikum-dresden.de)
- At diagnosis, 80% were T-cell immunophenotype, 70% were stages III to IV, 70% had mediastinal involvement, and 9% had central nervous system (CNS) disease. (ashpublications.org)
- Additionally, approximately 10% of patients with ALL have disseminated intravascular coagulation (DIC) at the time of diagnosis. (medscape.com)
- The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Intensive2
- Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. (frontiersin.org)
- This procedure starts with the patient receiving intensive chemotherapy with or without total body irradiation in an attempt to kill all cancerous cells. (lovesorghum.com)
Recipients2
- Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)
- Allogeneic methods are more akin to the pharmaceutical model of drug manufacturing as products can be produced on a larger scale and can be prepared for 'off the shelf' distribution, provided the recipients have an immunological profile matching the cells or cell products. (ddw-online.com)
Marrow40
- The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
- When these higher doses are used to kill the cancer cells, the normal bone marrow cells will also be destroyed. (ucsfhealth.org)
- The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
- The cells in the bone marrow that develop into all of the different types of blood cells listed above are called stem cells. (ucsfhealth.org)
- These are the important cells that are transferred during bone marrow or stem cell transplantation. (ucsfhealth.org)
- Stem cells are found predominantly in the bone marrow but occasionally can be stimulated to travel out into the blood. (ucsfhealth.org)
- When bone marrow or blood stem cells are infused into the recipient, they are administered through an intravenous catheter or central venous catheter, just like a blood transfusion. (ucsfhealth.org)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
- For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
- The plasma cells can also form a mass in the bone marrow or soft tissue. (wikipedia.org)
- Varicella zoster virus infections following allogeneic bone marrow transplantation: frequency, risk factors, and clinical outcome. (nature.com)
- These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
- Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
- Hu G, Liu P, Feng J, Jin Y. Transplantation with Bone Marrow Stromal Cells Promotes Wound Healing Under Chemotherapy through Altering Phenotypes. (ijbs.com)
- Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
- Infiltration of the marrow by massive numbers of leukemic cells frequently manifests as bone pain. (medscape.com)
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
- Bone Marrow Transplantation (BMT) is a medical procedure that involves replacing damaged or diseased bone marrow with healthy bone marrow stem cells. (vanyahealth.com)
- There are two main types of Bone Marrow Transplantation (BMT): autologous and allogeneic. (vanyahealth.com)
- The donor's stem cells will engraft in the patient's bone marrow and start producing new blood cells. (vanyahealth.com)
- This occurs when the donated cells do not engraft or grow properly in the patient's bone marrow. (vanyahealth.com)
- The bone marrow makes blood cells. (medlineplus.gov)
- It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
- As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
- An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)
- The lymph system includes the spleen, thymus, tonsils, bone marrow, lymph nodes and circulating white blood cells called lymphocytes. (hoapb.com)
- Some patients report that of these, the most difficult is the bone marrow biopsy. (hoapb.com)
- Bone marrow, found in the center of most large bones, is a spongy material that produces red blood cells, white blood cells and platelets. (hoapb.com)
- Although a bone marrow biopsy is typically associated with little pain and only takes about 10 to 20 minutes, many patients do have fear, and anxiety before this procedure. (hoapb.com)
- Patients should talk to their doctor before the procedure in order to understand how to manage or minimize any discomfort or anxiety associated with a bone marrow biopsy. (hoapb.com)
- Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
- G-CSF mobilizesCD34+ hematopoietic stem cells from bone marrow into the blood. (fliphtml5.com)
- The findingssupport the hypothesis that G-CSF mobilizes two distinct stem cell populations, one from the bone marrow andthe other from the spleen. (fliphtml5.com)
- After applying high doses of chemotherapy, we rescue the person with his or her own cells to repopulate his or her bone marrow and start the normal production of red blood cells, white blood cells and platelets again ," states the doctor. (mdanderson.es)
- New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
- p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
- Remission is when there are less than 5% blast cells in the bone marrow. (oncolink.org)
HSCT5
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
- and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)
- This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
- The final sample consisted of 35 records patients aged between 2 and 18 years old who underwent HSCT from February 2008 to December 2015 and who presented the data necessary for the study. (bvsalud.org)
Donors1
- Results Natural killer cells from healthy donors and myeloma patients expanded a median of 804- and 351-fold, respectively, without significant T-cell expansion. (haematologica.org)
Myeloid2
- Leukemia involving myeloid cells is called myeloid or myelogenous leukemia. (healthline.com)
- Myeloid cells are immature blood cells that would normally become granulocytes or monocytes. (healthline.com)
Malignant5
- All patients with malignant lung diseases will be supported inderdisciplinarily by the collegues of the University CancerCenter to safeguard the post possible way of treatment. (uniklinikum-dresden.de)
- In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
- With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
- The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
- Cancers that begin in cells of the lymph system are referred to as malignant lymphomas. (hoapb.com)
Leukemia9
- [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
- Leukemia can refer to all cancers affecting the white blood cells. (healthline.com)
- Leukemia is a cancer of the blood cells. (healthline.com)
- Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. (healthline.com)
- Leukemia is also classified according to the type of cell that's affected. (healthline.com)
- Hairy cell leukemia is a very rare subtype of CLL. (healthline.com)
- The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
- A lumbar puncture (spinal tap) to see if there are any leukemia cells in your spinal fluid. (oncolink.org)
- The treatment is designed to wipe out the abnormally functioning leukemia cells. (oncolink.org)
Clinical7
- Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
- Recent clinical studies have shown that highly immunosuppressive yet non-myeloablative doses of fludarabine-based chemotherapy can result in alloengraftment. (drugpatentwatch.com)
- Unfortunately, the term is often used to describe any patient with a TMA who does not have severe ADAMTS13 deficiency or a documented Shiga toxin, therefore it has little clinical usefulness. (medilib.ir)
- PACCE: A Randomized, Open-Label, Controlled, Clinical Trial of Chemotherapy and Bevacizumab With and Without Panitumumab in the First-line Treatment of Subjects With A Phase 3 Clinical Trial Comparing Infusional 5 Fluorouracil, Leucovorin, and Oxaliplatin. (med-abstracts.com)
- Enrichment of PBSCT by purification of CD34+stem cells fails to produce superior clinical benefits. (fliphtml5.com)
- The inferior clinical performance of CD34+-enriched and purified PBSCTs compared tounenriched PBSCTs may be explained by the omission of Hox11+ stem cells. (fliphtml5.com)
- clinical conditions of the patient, the existence of a tumors are considered rare (KLUSMANN et al. (bvsalud.org)
Remission1
- For these patients, following additional therapies are often successful in providing another remission. (lymphomaindia.com)
Versus4
- This treatment was complicated by graft-versus-host disease, and the patient required ongoing immunosuppression. (cdc.gov)
- The spleen also uniquely contributes toGraft Versus Host Disease (GVHD) complete B cell memory [11]. (fliphtml5.com)
- The fundamental problem here is that the graft-versus-host effect, that is, the infused cells and the new immune system, reject the patient. (mdanderson.es)
- The Clinically Actionable Molecular Profile of Early versus Late-Stage Non-Small Cell Lung Cancer, an Individual Age and Sex Propensity-Matched Pair Analysis. (cdc.gov)
Platelets2
- There are several broad categories of blood cells, including red blood cells (RBCs), white blood cells (WBCs), and platelets. (healthline.com)
- See "HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets)" and "Evaluation and treatment of hypertensive emergencies in adults" and "Catastrophic antiphospholipid syndrome (CAPS)" and "Early complications of hematopoietic cell transplantation", section on 'Thrombotic microangiopathy' . (medilib.ir)
Commonly1
- G-CSF is a commonly used mobilizing agent for practically all autologous and a majority of allogeneic HSCTs and is known to increase CD34+ concentration. (bdbiosciences.com)
Doses2
- Destruction of abnormal cells through administration of chemotherapy , at either low, conventional, or high doses, depending on the condition of the patient and the aggressiveness of their disease. (hoapb.com)
- Once prepared, the haematopoietic progenitors are infused back into the patient after an intensification process with high doses of chemotherapy . (mdanderson.es)
Infections5
- Endonuclease analysis of viral DNA from varicella and subsequent zoster infections in the same patient. (nature.com)
- However, in these patients, one must assume that all fevers are from infections until proved otherwise, because a failure to treat infections promptly and aggressively can be fatal. (medscape.com)
- Infections are still the most common cause of death in patients undergoing treatment for ALL. (medscape.com)
- Most patients also develop a slowly progressive defect in cell-mediated immunity (T-cell function) that, in advanced disease, contributes to common bacterial and unusual fungal, viral, and protozoal infections. (msdmanuals.com)
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Induction3
- However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
- We found that VZV reactivation occurred in 57 (30%) patients, in 8.5% during induction and in 21.5% after ASCT peaking at 8 months after ASCT. (nature.com)
- Chemotherapy for AML is broken down into three phases: induction phase, consolidation (or intensification), and maintenance phase. (oncolink.org)
Toxicity2
- Nevertheless, myelosuppression can be reversed by autologous stem cell transplantation (SCT), even without additional toxicity ( 4 , 5 ). (ijbs.com)
- Either method for measuring cardiac function is acceptable, however, the same scan must be used throughout treatment and follow-up to monitor the patient for cardiac toxicity. (stanford.edu)
Therapies are often1
- For research purposes, autologous cell therapies are often favoured because they do not require immunological matching and are personalised to the patient. (ddw-online.com)
Procedure2
Proliferation2
- Rps14 upregulation promotes inner ear progenitor proliferation and hair cell regeneration in the neonatal mouse cochlea. (stembook.org)
- Splenomegaly might reflect dramatic G-CSF-inducedG-CSF stimulation also in multiple studies shows faster recovery of Hox11+ stem cell proliferation. (fliphtml5.com)
Apheresis1
- Quantitating the CD34+ cell population can also be useful during mobilization as well as for determining the optimal timing of apheresis sessions to make sure that enough CD34+ cells have been harvested. (bdbiosciences.com)
Complications2
- These patients may present with hemorrhagic or thrombotic complications. (medscape.com)
- To reduce the risk of these complications, special techniques are used to purify the donor's stem cells before transplantation. (vanyahealth.com)
Blood stem cells1
- There are two types of stem cell transplantation depending on the source of the replacement blood stem cells - autologous (AUTO) and allogeneic (ALLO). (zenonco.io)
Mediastinal3
- Chest radiographs may reveal signs of pneumonia and/or a prominent mediastinal mass in some cases of T-cell ALL. (medscape.com)
- Computed tomography (CT) scans can further define the degree of lymphadenopathy in some patients, including those with mediastinal masses. (medscape.com)
- Others, particularly those with T-cell ALL, present with symptoms related to a large mediastinal mass, such as shortness of breath. (medscape.com)