• High-dose sequential chemotherapy followed by autologous stem cell transplantation in relapsed and refractory aggressive non-Hodgkin's lymphoma: results of a multicenter phase II study. (smw.ch)
  • Advanced stages of neuroblastoma are treated with intensive chemotherapy in combination with an autologous bone marrow transplant, which is usually followed by a vitamin A derivative administered orally for 6 months. (khcc.jo)
  • All of the study participants had end-state refractory (nonresponsive) multiple myeloma, said Dr. Singhal, and each one had previously relapsed following treatments with other therapeutic modalities, including 75 who had received one bone marrow transplant and 56 who had had two prior transplants. (cancernetwork.com)
  • Current clinical trials at MTRC, under the leadership of Bart Barlogie, MD, address the usefulness of adding thalidomide to primary induction therapy for newly diagnosed patients with myeloma, followed by tandem transplant and consolidation therapy. (cancernetwork.com)
  • Recent transplant, chronic lymphocytic leukaemia, [and] active chemotherapy might all reduce efficacy, but patients should be vaccinated anyway, as should their immediate carers," says Boyle. (cosmosmagazine.com)
  • The more people are willing to donate stem cells the more patients can find a suitable donor and receive a transplant. (oslo-universitetssykehus.no)
  • When a patient needs a transplant, we will search for a donor with the same tissue type as the patient. (oslo-universitetssykehus.no)
  • The purpose of the transplant is that the new stem cells will establish a new production of blood cells and blood platelets in the patient. (oslo-universitetssykehus.no)
  • A short-chain fatty acid made by bacteria in the gut could play an important role in graft-versus-host disease (GVHD) after allogeneic bone marrow transplant in mice. (oncologynurseadvisor.com)
  • Damage to the pelvic area from treatment for any type of cancer in that region-including testicular, prostate, rectal, colon, and bladder cancers-such as radical prostatectomy, radiation therapy, and orchiectomy, as well as stem cell or bone marrow transplant, can lead to erectile dysfunction. (ascopost.com)
  • A bone marrow transplant is the replacement of diseased or damaged bone marrow cells with new bone marrow cells that have been stored, frozen or obtained from a bone marrow donor. (ucsfhealth.org)
  • In essence, a bone marrow transplant uses very high doses of therapy in attempt to cure the cancer. (ucsfhealth.org)
  • When the stem cells are collected from the hip bone by performing many bone marrow aspirations (usually performed in the operating room), the transplant procedure is called a bone marrow transplant. (ucsfhealth.org)
  • However, having a bone marrow transplant remains a dangerous and difficult procedure. (ucsfhealth.org)
  • A bone marrow transplant is a procedure that replaces a person's faulty bone marrow stem cells. (medlineplus.gov)
  • Before you have a transplant, you need to get high doses of chemotherapy and possibly radiation. (medlineplus.gov)
  • What Is a Bone Marrow Transplant? (medlineplus.gov)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • 05). Life-threatening cardiac toxicity was not significantly increased in patients with pathologic results before transplant. (slideshare.net)
  • Since the 1990s, to do a bone marrow transplant, a patient had to have a sibling with a complete tissue match and take a medication that suppresses their immune system (Cyclophosphamide), as well as high dose chemotherapy. (medlineplus.gov)
  • Also, I'd like to figure out why a transplant works in some patients rather than others and also focus our approach instead of generally suppressing the whole immune system. (medlineplus.gov)
  • Not everyone can get a bone marrow transplant. (medlineplus.gov)
  • 0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)
  • Cytomegalovirus Glycoprotein Polymorphisms and Increasing Viral Load in Non-Transplant Patients with Hematological Malignancies Undergoing Chemotherapy: A Prospective Observational Study. (cdc.gov)
  • The problem can also arise in patients after bone marrow transplants, as the clinical and histologic features of PPE can be similar to cutaneous manifestations of acute (first three weeks) graft-versus-host disease. (wikipedia.org)
  • In human patients who receive bone marrow transplants, GVHD can cause severe gut damage from donor cells attacking host cells. (oncologynurseadvisor.com)
  • This study, published in Nature Immunology , first examined chemicals made by gut bacteria after the mice received allogeneic bone marrow transplants. (oncologynurseadvisor.com)
  • Bone marrow transplants can be important components for treating some types of leukemia and lymphoma. (oncologynurseadvisor.com)
  • Sickle cell disease (SCD) specialists have performed bone marrow transplants in children since the 1990s. (medlineplus.gov)
  • Bone marrow transplants are not working in 100% of patients. (medlineplus.gov)
  • Currently, recipients that undergo BMT are treated with toxic agents such as radiation and chemotherapy in order to in order to eliminate their own blood forming stem cells and permit the donor cells to take and develop. (ca.gov)
  • Candida infections in patients treated with chemotherapy or radiation after bone marrow transplantation. (njacs.org)
  • Radiation therapy has been used as part of the treatment for this lymphoma in adults but may not be necessary if high dose chemotherapy is used in the treatment plan. (dana-farber.org)
  • this clinical situation requires adjuvant chemotherapy and radiation therapy. (aao.org)
  • However, in a recent COG report, the authors demonstrated that intensive multimodal therapies-including high-dose chemotherapy, radiation, and bone marrow transplantation-have enabled improved efficacy for curing patients with regional extraocular retinoblastoma (87% event-free survival [EFS] at 36 months) and metastatic retinoblastoma not involving the CNS (79% EFS at 36 months), while rates for patients with CNS disease continue to be dismal (8% EFS at 36 months). (aao.org)
  • It is recommended that patients with germline RB1 mutations adhere to lifelong risk-modification practices, such as not smoking, avoiding unnecessary radiation exposure, and applying sunscreen. (aao.org)
  • For both men and women, changes in body image that are caused by surgery, radiation, and chemotherapy, such as alopecia, scars, and deformities, can affect the sense of sexual attractiveness and reduce interest in sexual activity and intimacy. (ascopost.com)
  • The NCCN, MASCC/ESMO, and ASCO guidelines include management recommendations for both chemotherapy-induced nausea and vomiting (CINV) and radiation-induced nausea and vomiting (RINV). (medscape.com)
  • He has carried out studies of stem cell transplantation following high-dose chemotherapy and radiation for acute myelogenous leukemia, one of the most common types of leukemia in adults. (uclahealth.org)
  • The administration of bone marrow usually occurs after a patient has received high-dose chemotherapy or radiation. (ucsfhealth.org)
  • The new bone marrow cells are infused after the toxic effects of the chemotherapy or radiation have cleared, and these cells will re-create a healthy bone marrow. (ucsfhealth.org)
  • For autologous transplantation, the patient receives his or her own bone marrow or stem cells that were collected and frozen before admission for high-dose chemotherapy or radiation. (ucsfhealth.org)
  • Acral erythema is a common adverse reaction to cytotoxic chemotherapy drugs, particularly cabozantinib, cytarabine, doxorubicin, and fluorouracil and its prodrug capecitabine. (wikipedia.org)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • The safety and efficacy of Neupogen are similar in adults and children receiving cytotoxic chemotherapy. (medicines.org.uk)
  • The first dose of Neupogen should be administered at least 24 hours after cytotoxic chemotherapy. (medicines.org.uk)
  • Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
  • In patients receiving cytotoxic chemotherapy, a transient increase in neutrophil counts is typically seen 1 to 2 days after initiation of Neupogen therapy. (medicines.org.uk)
  • The use of combination chemotherapy after initial surgery has dramatically improved the prognosis for many women with these tumors. (kaiserpermanente.org)
  • A review of the literature in 1979 prior to the widespread use of combination chemotherapy found only 27% of 96 patients with stage I endodermal sinus tumor alive at 2 years after diagnosis. (kaiserpermanente.org)
  • Stage III and IV patients of these patients with low-grade Hodgkin's disease were first treated with combination chemotherapy and then with radiotherapy, if indicated. (nethealthbook.com)
  • TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
  • Aetiology of cancer, influence of nutrition on cancer development, nutrition of oncology patients Pharmacotherapy of malignant diseases and adverse effects of these drugs- Radiotherapy of malignant diseases, adverse effects of radiotherapy Basic information's about most frequent cancer diseases Urological cancer Digestive tract cancer Lung cancer Gynaecologic cancer Bone marrow transplantation, indication, methods, results. (muni.cz)
  • Treatment may include surgery, chemotherapy, radiotherapy and/or bone marrow transplantation. (khcc.jo)
  • Stage III and IV needs quite sophisticated multi drug chemotherapy followed often by radiotherapy. (nethealthbook.com)
  • Note: Patients in the table above were only treated with radiotherapy for stage I and II. (nethealthbook.com)
  • A New Complex Karyotype Involving a KMT2A-r Variant Three-Way Translocation in a Rare Clinical Presentation of a Pediatric Patient with Acute Myeloid Leukemia. (cancerindex.org)
  • Patients with childhood acute myeloid leukemia (AML) with complex karyotypes (CKs) have a dismal outcome. (cancerindex.org)
  • Acute leukemia affects cells in bone marrow before they fully develop. (carle.org)
  • As Assistant DCOS for Acute Care Hospital Operations, he provides administrative and clinical guidance to clinical service staff in the areas of inpatient performance, patient flow optimization, policy review, project planning, and process improvement initiatives. (stanford.edu)
  • Dr. Schiller is a well-published clinical investigator in acute and chronic leukemias, multiple myeloma, and other hematologic malignancies, as well as in stem cell and bone marrow transplantation. (uclahealth.org)
  • A male 13-year-old patient with chondroblastic osteosarcoma in the left distal thigh and acute lymphoblastic leukemia undergoing cancer treatment with methotrexate presented with severe oral mucositis. (bvsalud.org)
  • AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
  • Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. (cdc.gov)
  • High-dose therapy (HDT) combined with autologous stem-cell transplantation (ASCT) provides superior response and survival outcomes versus standard chemotherapy in patients with newly diagnosed (ND) multiple myeloma (MM). 1 , 2 Standard induction chemotherapy regimens, however, are often associated with hematologic stem-cell toxicity, which may compromise the collection of stem cells for ASCT. (haematologica.org)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
  • Unlike allogenic bone marrow transplantation, where you use cells from the immune system of another person to fight the cancer and run the risk of the donor immune system attacking patient's organs, CAR-T therapy uses the patient's own cells," said Dr. Gerhard Hildebrandt , division chief of Hematology and Blood and Marrow Transplantation at UK. (uky.edu)
  • About a week prior to a stem cell transplantation, the patient receives pre-treatment to eradicate the patient's own bone marrow cells. (oslo-universitetssykehus.no)
  • The transfused stem cells find their way to the patient's bone marrow and 'settle down' there. (oslo-universitetssykehus.no)
  • The patient's clinical condition deteriorated over the next 36 hours despite steroid and antibiotic therapy, and the patient had to undergo a total colectomy and ileostomy. (medscape.com)
  • With chemotherapy, however, considerable improvement in the duration and quality of the patient's life can be expected. (vin.com)
  • Chemotherapy-induced mucositis is one of the most important undesirable side effects of cancer treatment, promoting the worst cases of morbidity, increasing length of hospital stay, and frequently reducing the odds of controlling the tumor and the patient's life expectancy 1 . (bvsalud.org)
  • Low-dose filgrastim significantly enhances neutrophil recovery following autologous peripheral-blood stem-cell transplantation in patients with lymphoproliferative disorders: evidence for clinical and economic benefit. (smw.ch)
  • If you are receiving Nivestym because you are also receiving chemotherapy, your dose of Nivestym should be injected at least 24 hours before or 24 hours after your dose of chemotherapy. (drugs.com)
  • Treatment for primary central nervous system lymphoma requires high doses of chemotherapy that enter the central nervous system, such as high-dose methotrexate and high-dose cytarabine. (dana-farber.org)
  • The problem is, most adults can't tolerate high doses of chemotherapy because their organs are already damaged and they don't have a sibling with an exact tissue match. (medlineplus.gov)
  • He also noted that thalidomide was also effective in patients with high grade myeloma, including those who had chromosome 13 deletion, which is usually refractory to high-dose chemotherapy and transplantation. (cancernetwork.com)
  • Other risk factors for survival were primary refractory disease, initial lymphoma stage, number of previous chemotherapy lines, and high amounts of blood product transfusions. (smw.ch)
  • High dose sequential chemotherapy and autologous stem cell transplantation in patients with relapsed/refractory lymphoma. (smw.ch)
  • The role of intensive therapy and autologous blood and marrow transplantation for chemotherapy-sensitive relapsed and primary refractory non-Hodgkin's lymphoma: identification of major prognostic groups. (smw.ch)
  • NCT04131621), patients relapsed or refractory after platinum-based chemotherapy received nivolumab and ipilimumab following TMBhigh vs. TMBlow stratification. (bvsalud.org)
  • For example, the presence of anemia along with thrombocytopenia with a low or high white blood cell count may suggest bone marrow involvement by leukemia. (medscape.com)
  • If marrow involvement is still present at harvest, then 2 additional courses of induction chemotherapy are given. (knowcancer.com)
  • The extension of bone marrow and extramedullary involvement should be carefully evaluated to establish prognosis and clinical management [ 4 ]. (hindawi.com)
  • Currently, whole-body X-ray scan is the most commonly used diagnostic tool in the evaluation of bone involvement in patients with MM, due to the rare occurrence of extraosseous sites. (hindawi.com)
  • The association with thyroid disease in the proband was explained partially by the involvement of the pituitary, with the relative risk decreasing when patients with diabetes insipidus and thyroid involvement were excluded from analysis. (thedoctorsdoctor.com)
  • Involvement of other organs, such as spleen, liver, or bone marrow is an indication of advanced disease. (vin.com)
  • Zhang QY, Foucar K. Bone marrow involvement by Hodgkin and non-Hodgkin lymphomas. (medscape.com)
  • Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. (kaiserpermanente.org)
  • Dr. Fakhri has co-authored numerous publications on topics including CLL, novel targeted agents, and cellular therapies for patients with hematologic malignancies. (stanford.edu)
  • recipients constituted 42% of those patients, while underlying malignancies were found in 26% (Table 1). (who.int)
  • Dr. Barlogie, the principal investigator of the thalidomide projects, added: We are extremely pleased with the efficacy of thalidomide in these patients that had failed all other therapies. (cancernetwork.com)
  • Those under hematological malignancy therapies such as bone-marrow transplantation and CAR T-cell therapy might need to wait longer for their immune system to recover. (cosmosmagazine.com)
  • In addition, the activation of haematopoiesis after antitumoral therapies could increase bone marrow FDG uptake diffusely. (hindawi.com)
  • As the only National Cancer Institute-designated cancer center in the state, it's our responsibility to bring innovative therapies like this to our patients, allowing them to receive the latest, greatest cancer care without having to cross state lines. (uky.edu)
  • As a clinical scientist, Dr. Fakhri is dedicated to caring for patients, teaching trainees, and researching novel therapies for patients with CLL/SLL. (stanford.edu)
  • Blood transfusion also plays a key role in the management of conditions such as haematological disorders (including leukaemia, haemophilia, thalassaemia), cancer chemotherapy, open heart surgery, and bone marrow and organ transplantation. (who.int)
  • CAR-T cell therapy is very promising - you can really bring about a complete remission in patients who have failed several other lines of treatment," Hildebrandt said. (uky.edu)
  • Patients who do not respond with a complete remission or who relapse within 6 to 12 months following initial chemotherapy, have a very poor prognosis. (nethealthbook.com)
  • Overall, COP chemotherapy causes complete remission in about 70% of dogs with lymphoma for a median of 130 days. (vin.com)
  • With each subsequent cycle of chemotherapy, the reaction will appear more quickly, be more severe and will take longer to heal. (wikipedia.org)
  • patients with severe chronic neutropenia. (drugs.com)
  • Chemotherapy safety and severe adverse events in cancer patients: strategies to efficiently avoid chemotherapy errors in in- and outpatient treatment. (ahrq.gov)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
  • ALPS 0 patients have the severe form of disease, characterized by neonatal or prenatal onset with marked hyperlymphocytosis. (lu.se)
  • The use of a treatment protocol consisting of a mucositis solution associated with low-level laser therapy effectively resolved a case of severe chemotherapy-induced oral mucositis. (bvsalud.org)
  • Bone marrow is spongy tissue in the middle of bones. (carle.org)
  • Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. (medlineplus.gov)
  • This is an English translation of the recruitment and consent brochure published in Norwegian by The Norwegian Bone Marrow Donor Registry (NBMDR), Department of Immunology, Oslo University Hospital. (oslo-universitetssykehus.no)
  • After you have been tissue typed, your data will be entered into the database of The Norwegian Bone Marrow Donor Registry. (oslo-universitetssykehus.no)
  • The 24-year-old woman, who was registered as a volunteer donor in the German Bone Marrow Donor Registry, was selected. (cdc.gov)
  • Thousands of patients undergo BMT yearly to successfully cure cancers or disorders of blood formation. (ca.gov)
  • Bone Marrow Transplantation (BMT) Bone marrow transplantation is done to treat blood cell cancers. (cancerquest.org)
  • these include an annual physical examination, with an assessment of the skin to identify second-primary skin cancers, as well as education regarding the signs and symptoms of bone and soft-tissue sarcomas. (aao.org)
  • Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect management, and new developments in specific cancers. (oncologynurseadvisor.com)
  • His approach is to put into clinical trials new treatments developed in the laboratory for patients with blood stem cell diseases or cancers of the bone marrow and blood. (uclahealth.org)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • Overview of Immunodeficiency Disorders Immunodeficiency disorders are associated with or predispose patients to various complications, including infections, autoimmune disorders, and lymphomas and other cancers. (msdmanuals.com)
  • Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer. (wikipedia.org)
  • However, the treatment for the underlying cancer of the patient must not be neglected. (wikipedia.org)
  • Psychological problems of cancer patient. (muni.cz)
  • Psychology of cancer patients, their families and nursing personal Informing patients about their malignant diseases. (muni.cz)
  • Chemotherapy Chemotherapy is a term for many different drugs used to treat cancer. (cancerquest.org)
  • The Drug Discovery and Development Process Cancer drugs take years to make their way to patients. (cancerquest.org)
  • The treatment given for cancer is variable and dependent on a number of factors including the type, location and amount of disease, and the health status of the patient. (cancerquest.org)
  • note that there are important differences in how these treatments affect the cancer cells and the patient (described below). (cancerquest.org)
  • Taking Care of Your Health features cancer-related information, health tips, patient stories and more. (moffitt.org)
  • The data were presented at the 40th annual meeting of the American Society of Hematology by Seema Singhal, MD, of the Myeloma and Transplantation Research Center (MTRC) of the Arkansas Cancer Research Center (ACRC), part of the University of Arkansas for Medical Sciences, Little Rock. (cancernetwork.com)
  • A male cancer patient receives a COVID vaccine injection in a Ukraine hospital. (cosmosmagazine.com)
  • But none of the COVID-19 vaccines has been trialled in cancer patients so far. (cosmosmagazine.com)
  • Many cancer organisations worldwide recommend that cancer patients, including those undergoing therapy, receive their COVID-19 jabs with priority. (cosmosmagazine.com)
  • The Australian Technical Advisory Group on Immunisation (ATAGI) has given a similar recommendation, but the federal government's Cancer Australia advises that the decision about whether to be immunised against COVID-19 should be made by the individual patient in consultation with their healthcare team. (cosmosmagazine.com)
  • Very few cancer patients were involved in the trials, mostly with the Pfizer vaccine, and not on active chemotherapy," says Professor Fran Boyle, the president of the Clinical Oncology Society of Australia and a professor of medical oncology at the University of Sydney. (cosmosmagazine.com)
  • But now that a huge number of people around the world have had vaccines, it's very reassuring that there hasn't been a signal that they are not safe in cancer patients. (cosmosmagazine.com)
  • The evidence from cancer patients' response to other vaccines suggests that, in principle, COVID-19 vaccines place no safety concerns. (cosmosmagazine.com)
  • Boyle says that live virus vaccines are generally avoided in cancer patients, but neither the Pfizer (an mRNA vaccine) nor the AstraZeneca (a non-replicating viral vector vaccine) fall into this category. (cosmosmagazine.com)
  • But the biggest concern at the moment is whether vaccines will offer cancer patients the same level of protection against COVID-19 as they do in the general population. (cosmosmagazine.com)
  • Early results from a study conducted in the UK on the Pfizer vaccine found that cancer patients had lower levels of protection after the first dose of the vaccine, compared to people without cancer. (cosmosmagazine.com)
  • Keefe says people undergoing chemotherapy should consider taking the vaccine one or two weeks after their cancer treatment. (cosmosmagazine.com)
  • Each cancer patient on therapy should discuss with their oncologist," she says. (cosmosmagazine.com)
  • Until a sufficiently large proportion of the community is vaccinated, cancer patients should take care after vaccination because it's difficult for a person to know whether the vaccine has worked in them," says Keefe. (cosmosmagazine.com)
  • But vaccines help reduce the severity of the infection, which is why it's really important that cancer patients get it. (cosmosmagazine.com)
  • Dana-Farber/Boston Children's also offers a wide array of support services and programs for pediatric patients and their families during and after cancer treatment. (dana-farber.org)
  • O'Brien C, Fogarty E, Walsh C, Dempsey O, Barry M, Kennedy MJ, McCullagh L, , The cost of the inpatient management of febile neutropenia in cancer patients - a micro-costing study in the Irish healthcare setting. (tcd.ie)
  • The most common type of second-primary cancer in these patients is osteosarcoma (also called osteogenic sarcoma ). (aao.org)
  • At Markey, this therapy will be used specifically for patients whose cancer has not responded to standard treatment, including chemotherapy and bone marrow transplantation. (uky.edu)
  • When these modified T-cells are infused back into the patient, these cells lock onto cancer cells using a "key - keyhole" approach, where their new receptor binds to a specific structure on the cancer cells. (uky.edu)
  • Most of the patients suffer from leukaemia (blood cancer) or other serious blood diseases, but patients with certain rare inborn metabolic disorders, inborn immunodeficiencies or extensive irradiation damage may also be treated. (oslo-universitetssykehus.no)
  • I have had patients at nationally ranked, research-based cancer centers and friends and family treated at MSTI. (stlukesonline.org)
  • Several genes have been found to be defective in some breast cancer patients. (stopgettingsick.com)
  • Relatives of breast cancer patients who carry these defective genes may be more likely to develop breast or ovarian cancer. (stopgettingsick.com)
  • The psychological distress of a cancer diagnosis and treatment, caused by changes in body image, depression, and anxiety, can further conspire to tamp down sexual desire and patients' ability to achieve arousal and orgasm. (ascopost.com)
  • Because oncologists rarely broach the subject with their patients and patients are often hesitant to raise the issue themselves, fearing embarrassment and the possibility of interfering with their cancer treatment, sexual dysfunction remains largely undiagnosed and untreated. (ascopost.com)
  • The ASCO Post talked with Patricia A. Ganz, MD , Director of the Division of Cancer Prevention and Control Research at UCLA's Jonsson Comprehensive Cancer Center and Director of the UCLA-LIVESTRONG Survivorship Center of Excellence, about how a cancer diagnosis and treatment affect the sexual health of men and women, and how oncologists can start a dialogue about sexual dysfunction with their patients. (ascopost.com)
  • Some patients may not feel comfortable talking about these issues with their oncologist, but asking the question lets them know that the oncologist is aware that sexual dysfunction is a potential problem during and after cancer treatment and that it is okay to talk about it. (ascopost.com)
  • Nausea and vomiting (N/V) is a common complication of cancer treatment and a common cause of anxiety and distress in patients, in some cases even prior to their first chemotherapy session. (medscape.com)
  • A case study for the shift in ethical focus is the treatment of advanced, metastatic breast cancer with high-dose chemotherapy followed by autologous bone marrow transplantation. (healthworkscollective.com)
  • Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of bone marrow transplantation. (ucsfhealth.org)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • This phase II trial studies how well olaparib works in treating patients with bladder cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. (bcan.org)
  • I. To evaluate the efficacy of olaparib in two cohorts of patients with metastatic/advanced non prostate genitourinary (GU) cancer pre-selected by DNA-repair defects as measured by overall response rate (ORR). (bcan.org)
  • I. To determine the proportion of patients with DNA-repair pathway-mutated genes in metastatic non-prostate GU cancer (patient cohort referred for screening). (bcan.org)
  • To determine the effectiveness of using next-generation sequencing (NGS) to identify DNA-repair pathway gene defects in tumor samples and circulating DNA and identify patients with non-prostate GU cancer suitable for PARP inhibition. (bcan.org)
  • COHORT I: Patients that have cancer-associated DNA-repair gene mutations receive olaparib orally (PO) twice daily (BID) on days 1-28 of each cycle. (bcan.org)
  • COHORT II: Patients that do not have cancer-associated DNA-repair gene mutations undergo blood sample collection at baseline. (bcan.org)
  • Of the SCCUP patients, 22 had cancer in a single area, and 14 in multiple areas. (bvsalud.org)
  • Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-based chemotherapy. (bvsalud.org)
  • 10-20% of patients have a high tumor mutational burden (TMB), which predicts response to immunotherapy in many cancer types. (bvsalud.org)
  • According to the medical record, the patient had been undergoing cancer treatment for one year and eight months. (bvsalud.org)
  • This explains why the assessment of eventual disease recurrence, persistence, or progression should not be performed shortly after the completion of chemotherapy cycles. (hindawi.com)
  • As time progresses, patients with graft-versus-host disease progress to have other body parts affected, while PPE is limited to hands and feet. (wikipedia.org)
  • 110 dogs were treated with a sequential chemotherapy protocol that used the above drugs (Madison-Wisconsin Protocol or AMC protocol). (vin.com)
  • V. Study the possible associations among patient- and disease-specific factors and family sociodemographic characteristics that mediate treatment outcome. (knowcancer.com)
  • We have developed a comprehensive plan for the treatment of SCID patients that we hope in the near future will replace the toxic treatments required to cure this disease. (ca.gov)
  • If the antibody treatment results a stronger blood system originating from a donor in SCID patients, this result would prove that the antibody could be used to optimize engraftment of gene-therapy modified cells and could be applied to the treatment the many other diseases that need a BMT. (ca.gov)
  • Physicians and researchers work close together to provide innovative treatment options for patients. (moffitt.org)
  • The epidemiology, mechanisms, diagnosis and treatment of cardiovascular disease in adult patients with HIV. (moffitt.org)
  • Access to safe blood and blood products for all patients whose treatment depends on transfusion will result in reductions in morbidity and mortality. (who.int)
  • These studies have identified candida, but not other enteric pathogens, in the stools of patients with diarrhoea and have reported symptom resolution following treatment. (bmj.com)
  • The scientific literature about the role of FDG-PET or PET/CT in evaluating the response to treatment in patients affected by MM was systematically reviewed. (hindawi.com)
  • FDG-PET or PET/CT seems to be helpful in assessing the response to treatment in patients with MM and in the evaluation of possible sites of recurrent or progressive disease. (hindawi.com)
  • Molecular imaging modalities such as Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT have emerged in the recent years as useful methods in the initial staging and treatment planning of patients affected by MM. (hindawi.com)
  • Therefore, patients receiving CAR-T therapy will be carefully screened prior to and monitored closely following their treatment. (uky.edu)
  • Hildebrandt notes that currently the therapy isn't approved as a first-line option for treatment but rather as a "rescue" when the standard of care has failed the patient. (uky.edu)
  • Communication matters when it comes to adverse events: associations of adverse events during implant treatment with patients' communication quality and trust assessments. (ahrq.gov)
  • Stem cell transplantation may be a life saving treatment in these conditions. (oslo-universitetssykehus.no)
  • You may withdraw at any time before the pre-treatment of the patient starts, and you do not need to give a reason. (oslo-universitetssykehus.no)
  • Outcome data are in line with previously reported studies, especially the data for salvage treatment and BEAM conditioning in DLBCL patients confirmed the outcome reported recently in a phase III study. (smw.ch)
  • Initial lymphoma stage and number of previous treatment lines were identified as independent risk factors for EFS in DLBCL and HL patients. (smw.ch)
  • Treatment for this condition remains difficult and largely ineffective, because the growth of cells in the wound is inhibited ( 2 ) and chemotherapy usually leads to myelosuppression, the latter of which further compromises the migration of multipotent cells from the bone marrow ( 3 ). (ijbs.com)
  • Following established chemotherapy for solid tumours, lymphomas, and lymphoid leukaemia, it is expected that the duration of treatment required to fulfil these criteria will be up to 14 days. (medicines.org.uk)
  • In addition, each patient should be individually assessed for this risk before the initiation of treatment and should be re-assessed regularly throughout treatment. (medscape.com)
  • 3) use new techniques, such as next-generation sequencing, RNAseq or signal cell sequencing, to explore key factors affecting liver disease and treatment in patients. (stanford.edu)
  • Under this program, eligible patients will incur no out of pocket costs for their first Nplate or Neulasta treatment associated with a new treatment regimen and will pay a maximum of $25 for subsequent injections. (amgen.com)
  • Patients were referred to our center when their family physician or general internist was stumped in making a diagnosis or referred for an expert treatment or to receive specialized treatment from a specialist who had multiple experiences with a particular disease or surgeries. (healthworkscollective.com)
  • This treatment was initially thought to offer perhaps a 10% chance of a significant extension of life for patients who would otherwise be fated to die very soon. (healthworkscollective.com)
  • Data now suggest that the actual chance of meaningful benefit from this treatment is zero and that the only effect of the treatment was to make patients' remaining months of life miserable. (healthworkscollective.com)
  • Once a definitive diagnosis has been obtained and after the patient has been staged accurately, the veterinarian should schedule a discussion with the owner regarding prognosis and treatment. (vin.com)
  • After completion of study treatment, patients are followed up at 4 weeks, every 2 months for 1 year, then every 3 months thereafter. (bcan.org)
  • The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
  • Assessing on-treatment dynamics of circulating tumor DNA using combined targeted hotspot mutation and shallow whole genome sequencing as part of a predefined exploratory analysis identified patients benefiting from immunotherapy irrespective of initial radiologic response. (bvsalud.org)
  • The monitoring and treatment of oral mucositis lesions in children and adolescents undergoing chemotherapy are necessary to prevent the patient from suffering from induced comorbidities. (bvsalud.org)
  • Moreover, oral mucositis induces pediatric patients to reduce food intake, which affects their nutritional status and makes them less responsive to treatment 4-5 . (bvsalud.org)
  • 5 reported that 78% of chemotherapy patients presented with mucositis at some point during treatment. (bvsalud.org)
  • Before the mucositis lesions appeared, the patient had been given a treatment protocol that included methotrexate (50mg) at 8-day intervals. (bvsalud.org)
  • Dasatinib was originally approved in 2006 by the US Food and Drug Administration (FDA) for the treatment of adult patients with chronic-phase CML resistant or intolerant to prior therapy that included imatinib. (medscape.com)
  • In October 2010, the FDA extended approval to include the treatment of newly diagnosed adult patients with Ph1-positive chronic-phase CML. (medscape.com)
  • Courtney Fitzhugh, M.D., is working to expand treatment options for sickle cell patients of all ages. (medlineplus.gov)
  • Evaluate the feasibility and outcome of bone marrow transplantation using family or unrelated donors in infants with the 11q23 abnormality. (knowcancer.com)
  • In Norway new bone marrow donors are only recruited among blood donors. (oslo-universitetssykehus.no)
  • We are trying to create a state where instead of completely replacing bone marrow with that of their donors, we are creating a mixture of donor and patient cells because we now know that as low as 20% donor cells is enough to reverse sickle cell disease. (medlineplus.gov)
  • I wanted to develop a way to have half-match donors contribute bone marrow and for the outcomes to be successful. (medlineplus.gov)
  • Patients with mature teratomas usually experience long-term survival, but survival for patients with immature teratomas after surgery only is related to the grade of the tumor, especially its neural elements. (kaiserpermanente.org)
  • Estimate the post complete/partial remission failure-free survival rate in these patients. (knowcancer.com)
  • OBJECTIVE: To assess the prognostic value of various parameters including positron emission tomography / computed tomography (PET/CT) and identify risk factors for survival of patients with non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL) treated with autologous stem cell transplantation (ASCT). (smw.ch)
  • METHODS: Patient charts and our prospective ASCT database were assessed for the impact of documented variables on event free survival (EFS) and overall survival (OS), including salvage and conditioning regimens used, and PET/CT results before and after ASCT. (smw.ch)
  • The only hope for long-term survival then is a bone marrow transplantation. (nethealthbook.com)
  • To follow patients without the pre-selected DNA-repair defects for survival. (bcan.org)
  • To correlate levels of baseline circulating tumor cells (CTCs) with survival in untreated patients. (bcan.org)
  • accordingly, most patients showed partial response or progression diseases with short survival time. (bvsalud.org)
  • The object of the statistical analysis is to compare the actual survival among the patients with the hypothetical counter-factual survival that would have occurred if no tx had been performed. (lu.se)
  • High-dose chemotherapy with autologous bone marrow transplantation: 11 years' experience in Zurich. (smw.ch)
  • At post transplantation day plus 3, antibiotic drug therapy was switched from piperacillin/tazobactam to meropenem. (cdc.gov)
  • Combination Systemic Chemotherapy plus 3-Drug Combination Intrathecal Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy. (knowcancer.com)
  • Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • 4-Drug Combination Systemic Chemotherapy plus Single-Agent Intrathecal Chemotherapy. (knowcancer.com)
  • Even in the unfavorable subset, local therapy was combined with systemic chemotherapy in only two cases, and four cases showed no recurrences. (bvsalud.org)
  • Painful red swelling of the hands and feet in a patient receiving chemotherapy is usually enough to make the diagnosis. (wikipedia.org)
  • More than 50% of the patients died within a year of diagnosis. (kaiserpermanente.org)
  • Schoenfeld D, Lee D, Arrington JA, Greene J, Klinkova O. Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis. (moffitt.org)
  • The results of a multiorgan workup performed at the time of diagnosis were predictive of which patients in this cohort manifested multisystem disease. (thedoctorsdoctor.com)
  • unreliable and unavailable commercially in most of the world [ 1 ], thus evaluation of A total of 19 patients were identified as appropriate specimens by smear and culture having a culture-proven diagnosis of remains the principal method of diagnosis. (who.int)
  • The results for Yescarta are impressive for these patients: 54 percent achieved remission and 52 percent were alive at 18 months, based on the ZUMA-1 trial published in the New England Journal of Medicine last year. (uky.edu)
  • Evaluate neuropsychologic outcome upon completion of protocol therapy in patients who have reached the ages of 3 and 7 years, with special attention to the outcome in infants who received total-body irradiation. (knowcancer.com)
  • Bone marrow transplantation (BMT) is the oldest and most common form of stem cell-based therapy. (ca.gov)
  • Combination vincristine, doxorubicin, and dexamethasone (VAD) is considered a standard infusional induction therapy for younger MM patients prior to HDT and ASCT. (haematologica.org)
  • In total, 89 patients participated in the trial, all of whom had exhausted conventional forms of therapy, including chemotherapy and bone marrow transplantation. (cancernetwork.com)
  • These recent findings are consistent with the results of an earlier analysis of 26 patients, which determined that over half of all patients with advanced disease developed either stable disease or improved with thalidomide therapy. (cancernetwork.com)
  • The place of high-dose BEAM therapy and autologous bone marrow transplantation in poor-risk Hodgkin's disease. (smw.ch)
  • High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. (smw.ch)
  • I usually raise the issue during adjuvant therapy and will ask patients, "How is your sex life? (ascopost.com)
  • Unfortunately not every patient with a poor prognosis will be eligible for this vigorous therapy. (nethealthbook.com)
  • A high index of suspicion is essential in susceptible patients presenting with pulmonary infiltrate, cerebral abscess or deep soft-tissue abscess and usually requires an active diagnostic workup and early administration of appropriate therapy. (who.int)
  • Staging carries prognostic significance and enables the veterinarian and client to make informed and rational decisions as to the type of therapy best suited for the patient. (vin.com)
  • It has also been used as a therapy for disorders like aplastic anemia, which are associated with bone marrow failure. (ucsfhealth.org)
  • According to the recent clinical trials in patients with metastatic RCC, a combination of immunotherapy and tyrosine-kinase inhibitors exhibited better response than conventional therapy or tyrosine-kinase inhibitors alone. (bvsalud.org)
  • Ponatinib is a kinase inhibitor indicated for patients with CML or Ph+ ALL that is resistant or intolerant to prior tyrosine kinase inhibitor therapy, including those with the T315I mutation. (medscape.com)
  • Because of its high risk for thromboembolic events, it is indicated for patients with T315I-positive, Ph+ ALL for whom no other TKI therapy is indicated. (medscape.com)
  • 6 , 9 The demonstrated efficacy, lack of myelosuppression, and overall tolerability of thalidomide provide a strong rationale for its incorporation in standard induction regimens for patients presenting with NDMM who may be eligible for ASCT. (haematologica.org)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • In contrast, other studies using targeted sequencing of children with idiopathic bone marrow failure or MDS found pathogenic variants in only approximately 10% of patients 16 , suggesting the need for more comprehensive sequencing. (nature.com)
  • Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. (smw.ch)
  • Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial. (smw.ch)
  • In selected patients, who will withstand the initial high chemotherapy dosage to wipe out the Hodgkin's cells in the system, a bone marrow transplantation can yield cure rates in more than 50% of patients. (nethealthbook.com)
  • Martí-Carvajal AJ, Cardona AF, Lawrence A. Interventions for previously untreated patients with AIDS-associated non-Hodgkin's lymphoma. (medscape.com)
  • In adults, PCNSL often occurs in patients with a weakened immune system. (dana-farber.org)
  • Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing, and/or RNA-sequencing of 46 pediatric primary MDS patients. (nature.com)
  • This is not surprising as there are well-accepted clinical and morphologic differences between pediatric and adult MDS (e.g., bone marrow hypocellularity is more common in children) leading the World Health Organization (WHO) to classify MDS differently in adults and in children 10 . (nature.com)
  • In this study we perform tumor and normal whole exome sequencing (WES) on 32 pediatric primary MDS patients and targeted sequencing on another 14 cases through a single institution study focused on defining the genomic landscape of pediatric MDS. (nature.com)
  • We show that Ras/MAPK pathway mutations are common in pediatric primary MDS (45%) while mutations in RNA splicing genes are rare (2%), and that germline SAMD9/SAMD9L mutations are present in 17% of primary MDS patients. (nature.com)
  • We performed next generation sequencing on a cohort of 77 pediatric patients with diagnoses of primary MDS ( n = 46), MDS/MPN ( n = 23, 19 of which were JMML), and AML-MRC ( n = 8) (Fig. 1 , Supplementary Data # 1 and Supplementary Fig. 1 ). (nature.com)
  • 2016 Updated American Society of Clinical Oncology/Oncology Nursing Society Chemotherapy Administration Safety Standards, including standards for pediatric oncology. (ahrq.gov)
  • Genetic and clinical characteristics of pediatric patients with familial hemophagocytic lymphohistiocytosis. (cdc.gov)
  • Lymphoma is the most common haematopoietic malignancy in dogs, and is the most responsive to chemotherapy. (vin.com)
  • Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. (medscape.com)
  • Patients present nonmalignant lymphadenopathy and splenomegaly, autoimmune phenomena and in some cases even malignancy. (lu.se)
  • Additional information could be provided by computed tomography (CT) and magnetic resonance imaging (MRI), while conventional bone scintigraphy is affected by low sensitivity because of inadequate osteoblastic activity in MM lesions [ 1 - 3 ]. (hindawi.com)
  • CONCLUSION: The combination of immunotherapy and tyrosine-kinase inhibitors is at least as effective as a tyrosine-kinase inhibitor alone, and superior to conventional chemotherapy for treating metastatic RCC of unknown primary origin. (bvsalud.org)