DonorBeta thalassemiaAcuteAntibodiesReactionsAllogeneicSevereBloodHemoglobinHematopoieticGranulocyteTRALIMedicine and HemotherapyRisk of transfusion transmitteAlloimmunizationAdhesion deficiencyRegular transfusionsComplicationsGraft versusNeutrophilInfectionRefractoryFebrilePediatricInfectionsThalassemia patientsRBCsIron chelationRequire transfusionBone marrow traRecipientsDiagnosticClinicalPlatelet countSickle cell diOrganIndicationsAnemiaHumanReductionChronicPlateletsThrombocytopenic patientsEfficacyPatient'sPeripheralTherapyHemostasisCytokineMortalityPulmonaryHemorrhageFiltrationAnaemiaTransplantNeutrophils
Donor20
- Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
- The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
- Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
- Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
- Antibodies directed against white blood cell (WBC) human leukocyte antigen (HLA) in otherwise compatible donor blood are one possible cause. (merckmanuals.com)
- The transfer of leukocytes from a donor to a recipient or reinfusion to the donor. (umassmed.edu)
- Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody. (umassmed.edu)
- Virus-induced abrogation of transplantation tolerance induced by donor-specific transfusion and anti-CD154 antibody. (umassmed.edu)
- Ensure that regulatory agencies and blood transfusion services have clear guidelines and standards for donor screening, testing, and quality control. (researchgate.net)
- Casgevy has been approved to treat patients with sickle cell disease with recurrent vaso-occlusive crises and transfusion-dependent beta-thalassemia aged 12 years or older, for whom a human leukocyte antigen (HLA) matched related hematopoietic stem cell donor is not available. (pharmaceutical-technology.com)
- New Delhi, May 4 : Thanks to his donor brother, a 25-year-old thalassemia patient is now living a transfusion-free life after undergoing a high-risk bone marrow transplant, doctors at BLK Super Speciality Hospital here said on Friday. (india4u.com)
- Bone marrow transplantation (BMT) is the only cure, but non-availability of a suitable HLA (human leukocyte antigen)-matched donor, inherent high risk of procedure and high cost restricts its practicality," Choudhary added. (india4u.com)
- Neither red cell donor was found to have anti-HLA or HNA antibodies nor testing of antibodies against HLA for the patient revealed multiple, high mean-fluorescent intensity class I and II anti-HLA antibodies. (cedars-sinai.edu)
- Blood is selected for transfusion so the blood groups of the donor match those of the patient receiving the blood as closely as possible. (nhsbt.nhs.uk)
- We use molecular polymerase chain reaction (PCR) techniques to identify patient (and donor) HLA antigens, but we also use serology-based techniques to identify antibodies directed again non-self HLA. (bshi.org.uk)
- Laboratories that support solid organ transplant provide a 24-7 oncall service to HLA type potential deceased organ donors and to enable a compatibility assessment (i.e. a crossmatch) to be performed where a patient is offered an organ from a potential donor as part of a national service. (bshi.org.uk)
- It was given approval for patients 12 years or older with transfusion-dependent beta-thalassemia who did not have a β0/β0 genotype and for patients where hematopoietic stem cell (HSC) transplantation wasn't appropriate, but a human leukocyte antigen (HLA)-matched related HSC donor isn't available. (biotechnology.report)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- Type and crossmatch assesses ABO/Rh blood type, the presence of antibodies, and patient and donor blood compatibility. (mhmedical.com)
- In critical situations, where there is no time to perform a complete ABO/Rh-typing, group O/Rh-negative blood ("universal donor") can be given to patients without waiting for a complete type and crossmatch. (mhmedical.com)
Beta thalassemia12
- Vertex and CRISPR's Casgevy has received conditional approval in the UK for treating sickle cell disease and transfusion-dependent beta-thalassemia. (pharmaceutical-technology.com)
- Casgevy has been approved for treating sickle cell disease and transfusion-dependent beta thalassemia patients aged 12 and older in the UK. (pharmaceutical-technology.com)
- The MHRA approval was based on two open-label Phase I/II/III clinical trial data evaluating Casgevy in patients with severe sickle cell disease (NCT03745287) and transfusion-dependent beta-thalassemia (NCT03655678). (pharmaceutical-technology.com)
- The FDA has approved Bluebird Bio's Zynteglo as the first cell-based gene therapy for the treatment of adult and pediatric patients with beta-thalassemia who require regular red blood cell transfusions. (genengnews.com)
- Today's approval is an important advance in the treatment of beta-thalassemia, particularly in individuals who require ongoing red blood cell transfusions," said Peter Marks, MD, PhD, director of the FDA's Center for Biologics Evaluation and Research. (genengnews.com)
- Transfusion-dependent beta-thalassemia, the most severe form of the condition, generally requires life-long red blood cell transfusions as the standard course of treatment. (genengnews.com)
- The FDA approval of Zynteglo offers people with beta-thalassemia the possibility of freedom from burdensome regular red blood cell transfusions and iron chelation, and unlocks new possibilities in their daily lives," said Andrew Obenshain, CEO of Bluebird Bio. (genengnews.com)
- The safety and effectiveness of Zynteglo were established in two multicenter clinical studies that included adult and pediatric patients with beta-thalassemia requiring regular transfusions. (genengnews.com)
- Bluebird bio released updated results from three clinical trials of its LentiGlobin gene therapy for transfusion-dependent Beta-thalassemia (TDT) at the 24thEuropean Hematology Association (EHA) Congress being held in Amsterdam, the Netherlands. (biotechnology.report)
- Frequency of secondary modifiers in Beta Thalassemia intermedia in patients from Northern Punjab. (cdc.gov)
- The Spectrum of HBB Mutations among 2315 Beta Thalassemia Patients of a Reference Clinic in Tehran-Iran. (cdc.gov)
- Mutational analysis of hemoglobin genes and functional characterization of detected variants, through in-silico analysis, in Pakistani beta-thalassemia major patients. (cdc.gov)
Acute11
- Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
- Patients who benefit most from the transfusion of RBCs include those with chronic anemia resulting from kidney failure or gastrointestinal bleeding, and those with acute blood loss resulting from surgery or trauma. (utmb.edu)
- Allergic reactions The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (merckmanuals.com)
- Because fever and chills also herald a severe hemolytic transfusion reaction, all febrile reactions must be investigated as for acute hemolytic transfusion reaction, as with any transfusion reaction. (merckmanuals.com)
- About 20 people die yearly in the US as a result of acute hemolytic transfusion reaction. (merckmanuals.com)
- ABO incompatibility is the most common cause of acute hemolytic transfusion reaction. (merckmanuals.com)
- Acute simple transfu- tance of providing antigen-matched blood sions are usually used to treat sequestration for chronic transfusion patients, such as crisis, aplastic crisis, blood loss and in pre- those with thalassaemia and SCA, in order operative preparation. (who.int)
- Transfusion-related acute lung injury (TRALI) is a serious complication that can develop either during or within 6 hours of blood transfusion. (cedars-sinai.edu)
- Objective: Acute lung injury (ALI) is a well known complication following the transfusion of blood products and is commonly referred to as transfusion-related acute lung injury (TRALI). (mednemo.it)
- [7-10] Acute respiratory distress immediately after the transfusion of blood and/or blood products has been increasingly recognized over the past two decades. (mednemo.it)
- This syndrome known as transfusion-related acute lung injury (TRALI), is considered the most common and serious complication associated with the transfusion of blood products. (mednemo.it)
Antibodies8
- The results were read macroscopi- patients had 1 alloantibody, while others cally and microscopically, and all nega- more than 1 and even multiple antibodies. (who.int)
- There is a higher risk of TRALI from high volume plasma containing blood products due to the presence of antibodies against human leukocyte antigens (HLA) or human neutrophil antigens (HNA). (cedars-sinai.edu)
- 1. Chen S, Cooper N, Müller M, Bein G, Sachs UJ (2020) Piperacillin-dependent anti-platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid-onset thrombocytopenia. (uni-giessen.de)
- 12. Sachs UJ, Wienzek-Lischka S, Duong Y, Qiu D, Hinrichs W, Cooper N, Santoso S, Bayat B, Bein G (2020) Maternal antibodies against paternal class I human leukocyte antigens are not associated with foetal and neonatal alloimmune thrombocytopenia. (uni-giessen.de)
- Having blood group antibodies means that it is harder to match blood and in some cases there is a delay in finding the blood for the patient. (nhsbt.nhs.uk)
- We mostly do this using serology - by using antibodies to different blood groups in patients and donors. (nhsbt.nhs.uk)
- NHS Blood and Transplant (NHSBT) based laboratories also perform HLA testing for patients who are refractory to platelet transfusions to identify if HLA antibodies could be a contributing factor. (bshi.org.uk)
- It is usually caused by anti-leukocyte antibodies, resolves rapidly, and has a low mortality. (mednemo.it)
Reactions2
- The high numbers of leukocytes remaining in a unit of pRBCs during the storage process can fragment, deteriorate, and release cytokines, and they have been implicated as a cause of reactions to a current and subsequent blood transfusions in some transfusion recipients. (utmb.edu)
- 1 transfusion with units of ABO and D reactions (DHTRs) that may occur. (who.int)
Allogeneic6
- Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
- Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)
- In 1971, hepatitis B surface antigen testing heralded the advent of screening to minimize infection transmission complicating allogeneic transfusion. (medscape.com)
- Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic transfusions. (karger.com)
- Allogeneic hematopoietic transplantation may be curative in some patients with thalassemia major. (medscape.com)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
Severe20
- Patient activity may be limited secondary to severe anemia. (medscape.com)
- Patients' quality of life is conditioned by the severity of the disease and, in the most severe cases, prevents them from leading a normal life, with a very high level of suffering due to the acuteness and frequency of the intestinal symptoms. (sciencedaily.com)
- However, over the course of the disease, as much as 70% of severe patients require surgery to remove segments affected by the disease, due to failure of the pharmacologic approach. (sciencedaily.com)
- There have also been a number of research who have cerebrovascular disease, compli- reports exploring the effect of transfusion cated pregnancy, cardiopulmonary disease from different ethnic and racial groups and and severe debilitating vaso-occlusive dis- the variability in rates of alloimmuniza- orders. (who.int)
- Thalassemia Major shows as severe form of anaemia necessitating lifelong blood transfusions and iron chelation. (india4u.com)
- Throughout her ICU stay there were multiple attempts to wean the patient from the ventilator that were ultimately unsuccessful in the setting of severe fibrotic lung disease and pulmonary hypertension. (cedars-sinai.edu)
- Prevention of worsening of severe thrombocytopenia after red cell transfusions by the use of leucocyte-depleted blood. (ox.ac.uk)
- Platelet counts were measured before and after red cell transfusions in 30 patients with anaemia and severe thrombocytopenia resulting from haematological diseases. (ox.ac.uk)
- In thalassaemia, people cannot produce enough haemoglobin, causing severe anaemia, which can be fatal if not treated with blood transfusions. (nhsbt.nhs.uk)
- These can be severe conditions and sometimes people need regular blood transfusions. (nhsbt.nhs.uk)
- Sickle cell disorder affects about 17,000 patients in England with 250 new cases per year, and there are approximately 800 people with severe thalassemia, with about 50 new cases per year. (nhsbt.nhs.uk)
- Association of SARS-CoV-2 nucleocapsid viral antigen and the receptor for advanced glycation end products with development of severe disease in patients presenting to the emergency department with COVID-19. (ucsf.edu)
- Twenty minutes into the transfusion, the patient starts complaining of severe flank pain and chills. (prospectivedoctor.com)
- thalassemia major patients with severe iron overload to SARS-CoV-2 infection and vaccination: a prospective cohort study. (cdc.gov)
- 2. The cardiovascular stability of patients with hypotension and severe water and sodium retention receiving hemofiltration therapy is significantly better than that of hemodialysis. (dajimed.com)
- Patients have a history of delayed separation of the umbilical cord, severe periodontitis, often with early tooth decay, and recurrent infections of the oral and genital mucosa, skin, and intestinal and respiratory tract. (lu.se)
- Severe gingivitis and periodontitis are major features among all patients who survive infancy. (lu.se)
- Patients with less than 1% of the normal CD18 surface expression have a severe form of disease with earlier, more frequent, and more serious episodes of infection, often leading to death in infancy. (lu.se)
- No dose adjustment is required, including in patients with severe renal impairment (creatinine clearance less than 30 mL/minute) (see sections 4.4 and 5.2). (who.int)
- However, linezolid should be used with special caution in patients with severe renal insufficiency, and only when the anticipated benefit is considered to outweigh the theoretical risk, because the clinical significance of higher exposure (up to 10 fold) to the two primary metabolites of linezolid is unknown. (who.int)
Blood78
- Any licensed independent practitioner can order a blood transfusion and obtain consent to do so. (medscape.com)
- In spite of widespread use, data supporting specific practice paradigms for whole blood and component therapy transfusion are lacking, the notable exception being in the primary treatment of hemorrhagic shock. (medscape.com)
- Opinions are embraced and defended, but transfusion of red blood cells has not reliably demonstrated increased survival, other than in 2 specific populations, as follows: (1) those with active hemorrhage, and (2) those with active cardiac ischemia. (medscape.com)
- [ 1 ] Massive transfusion protocols (MTPs) should be institutionally monitored by a blood utilization committee that can track initiation, cessation, component wastage, storage of blood products outside of the blood bank, transport standards, and compliance with applicable Food and Drug Administration (FDA) standards. (medscape.com)
- The history of blood transfusion originated with William Harvey's discovery of blood circulation in 1628. (medscape.com)
- The earliest known blood transfusions occurred in 1665, and the first human blood transfusion was performed by Dr. Philip Syng Physick in 1795. (medscape.com)
- The first transfusion of human blood for the treatment of hemorrhage was performed by Dr. James Blundell in London in 1818. (medscape.com)
- Fresh whole blood has long been thought of as the criterion standard for transfusion, but the advent of whole blood fractionation techniques subsequent to World War II provided a means of more efficient use of the various components (i.e., packed red blood cells [PRBCs], fresh frozen plasma [FFP], individual factor concentrates, platelet concentrates, cryoprecipitate). (medscape.com)
- The most widespread use of whole blood transfusion is the US military buddy transfusion system. (medscape.com)
- [ 2 ] Additionally, whole blood transfusion in civilian pre-hospital settings and in the trauma bay is seeing a resurgence in some regions. (medscape.com)
- Leukapheresis - leukocytes (white blood cells). (wikipedia.org)
- Leukocyte-reduced red blood cells are prepared using special filters and have special indications. (utmb.edu)
- Patients undergoing fludarabine therapy (purine analog) , bone marrow transplantation or peripheral blood stem cell transplantation. (utmb.edu)
- Patients receiving granulocyte components, components that are HLA matched, or directed donations (from blood relatives) . (utmb.edu)
- Blood banking considerations for these patients include completely typing their erythrocytes for Rh and ABO antigens prior to the first transfusion. (medscape.com)
- Transfusion of washed, leukocyte-poor red blood cells (RBCs) at approximately 8-15 mL RBCs per kilogram (kg) of body weight over 1-2 hours is recommended. (medscape.com)
- Early recognition of symptoms suggestive of a transfusion reaction and prompt reporting to the blood bank are essential. (merckmanuals.com)
- Further transfusion should be delayed until the cause of the reaction is known, unless the need is urgent, in which case type O Rh-negative red blood cells (RBCs) should be used. (merckmanuals.com)
- ABO and Rh typing There has been a gradual decrease in overall transfusion due to patient blood management programs. (merckmanuals.com)
- Mislabeling the recipient's pretransfusion sample at collection and failing to match the intended recipient with the blood product immediately before transfusion are the usual causes. (merckmanuals.com)
- Avoiding and monitoring transfusion-transmissible diseases (TTDs) is crucial to ensure the safety of blood transfusions and protect both donors and recipients. (researchgate.net)
- With this, why is transfusion transmissible infection (TTI) such as Cytomegalovirus not routinely tested among blood donors in several countries like Nigeria? (researchgate.net)
- Whole blood is primarily used for transfusion in adults with massive blood loss and active bleeding, who generally require all the blood components. (medicinenet.com)
- Whole blood may also be reconstituted using stored plasma, red blood cells (RBCs), and platelets, usually used for cardiovascular surgeries and exchange transfusions in newborn babies . (medicinenet.com)
- Fresh whole blood is not commonly used or available any longer in most of the U.S. Currently, the most common use of whole blood is for the donor's own transfusion (autologous) when needed during or after elective surgery. (medicinenet.com)
- Whole blood contains all the blood components including red blood cells, platelets, stable clotting factors and plasma, providing volume and all the necessary components to control bleeding in rapidly hemorrhaging patients. (medicinenet.com)
- Whole blood transfusions should not be used when only a specific blood component is required and available. (medicinenet.com)
- Whole blood can cause volume overload and other complications in patients who have adequate volume and only require a specific blood component. (medicinenet.com)
- ABO blood group should be matched to the recipient and only the identical group should be used for transfusion, because whole blood contains plasma and red blood cells. (medicinenet.com)
- Transfusion should not be delayed waiting for reconstituted whole blood in emergency transfusions, because reconstitution is a time-consuming process. (medicinenet.com)
- All whole blood transfusions must be given using blood administration sets containing 170- to 260-micron filters or 20- to 40-micron microaggregate filters, unless transfusion is given via a bedside leukocyte reduction filter. (medicinenet.com)
- Monitor patients for signs of transfusion reaction, including vital signs, before, during, and after whole blood transfusion . (medicinenet.com)
- If transfusion reaction is suspected, stop the transfusion, assess and stabilize the patient, and notify the blood bank to initiate an investigation. (medicinenet.com)
- Massive or rapid transfusion of whole blood may lead to arrhythmias, hypothermia , hypocalcemia, hyperkalemia , metabolic alkalosis, and heart failure . (medicinenet.com)
- Whole blood transfusions carry the risk for non-septic infections including human immunodeficiency virus ( HIV ) hepatitis B and C viruses ( HBV and HCV ), human T-lymphotropic virus (HTLV), cytomegalovirus ( CMV ), West Nile virus (WNV), parvovirus B19, Lyme disease , babesiosis , malaria , Chagas disease and variant Creutzfeldt-Jakob disease ( vCJD ). (medicinenet.com)
- Consult with the blood bank medical director or a hematologist if you have questions regarding special transfusion requirements. (medicinenet.com)
- After ABO and Rh blood grouping by the patients develop multiple alloantibodies, standard tube method, the following were which further complicate their situation. (who.int)
- Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population. (jamanetwork.com)
- Thalassemia patients generally have to get frequent blood transfusions to manage their condition. (india4u.com)
- He used to manage his condition with regular blood transfusions, but after marriage he started exploring options to put a stop to it in the hope of preventing the future generation from inheriting the disorder. (india4u.com)
- Berwal had undergone blood transfusions since he was three-and-a-half years old. (india4u.com)
- Effectiveness was established based on achievement of transfusion independence, which is attained when the patient maintains a pre-determined level of hemoglobin without needing any red blood cell transfusions for at least 12 months. (genengnews.com)
- There had been no additional blood transfusion or evidence of infection or cardiovascular dysfunction. (cedars-sinai.edu)
- This case report highlights rare but significant adverse effect of blood transfusion. (cedars-sinai.edu)
- Sickle cell disorder and thalassaemia are both inherited blood disorders where people are often treated with blood transfusions. (nhsbt.nhs.uk)
- We are only offering testing in these disorders if patients need regular blood transfusions - there are about 200 patients in England who fit these criteria. (nhsbt.nhs.uk)
- Before a person receives a transfusion, they have a test in the hospital to check their basic blood groups. (nhsbt.nhs.uk)
- When the blood laboratory team choose blood for patients, they check that the blood group of the donors matches your blood groups as closely as possible. (nhsbt.nhs.uk)
- As we don't match for all the blood groups, transfused may contain blood groups present which the patient does not have. (nhsbt.nhs.uk)
- Most of the time, the patients' immune system ignores this, but sometimes the immune system recognises the difference and makes an antibody against the blood group. (nhsbt.nhs.uk)
- For some patients, blood can be found, but not enough blood. (nhsbt.nhs.uk)
- How do we find out the blood groups for donors and patients? (nhsbt.nhs.uk)
- COHORT II: Patients that do not have cancer-associated DNA-repair gene mutations undergo blood sample collection at baseline. (bcan.org)
- There was no prior history of blood transfusion. (ispub.com)
- OBJECTIVE: There is mixed evidence regarding the association of perioperative blood transfusion to disease recurrence and mortality in head and neck cancer patients. (bvsalud.org)
- The presented study was undertaken to ascertain whether perioperative transfusion of leukodepleted blood is associated with recurrence and survival in head and neck cancer surgery patients. (bvsalud.org)
- In addition to age, T stage, and N stage, multivariate analysis revealed leukodepleted blood transfusion to be an independent predictor of both recurrence (odds ratio 1.6) and survival (hazard ratio 1.5). (bvsalud.org)
- CONCLUSION: Perioperative transfusion of leukodepleted blood is associated with higher recurrence rates and decreased survival in head and neck cancer surgery. (bvsalud.org)
- Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. (phcogj.com)
- PCs were transfused into 48 blood malignancy patients, Yogyakarta, consisting of two groups i.e the group transfused with nonleucodepleted PCs (24 patients) and the group transfused with leucodepleted PCs (24 patients). (phcogj.com)
- Data synthesis: The classic TRALI syndrome is an uncommon condition characterized by the abrupt onset of respiratory failure within hours of the transfusion of a blood product. (mednemo.it)
- While the delayed TRALI syndrome can develop after the transfusion of a single unit, the risk increases as the number of transfused blood products increase. (mednemo.it)
- Conclusions: Both the classic and delayed TRALI syndromes are among the most important complications following the transfusion of blood products and are associated with significant morbidity and increased mortality. (mednemo.it)
- The risk and benefits of all blood products should be assessed before transfusion. (mednemo.it)
- In recent years blood transfusion requirements have been increasing because of the increasing burden of chronic disease in an aging population, improvement in life-support technology with an increasing severity of illness and blood-intensive surgical procedures. (mednemo.it)
- [2] This increased use has occurred despite growing concern regarding the safety of blood transfusions and the benefits of a restrictive transfusion strategy. (mednemo.it)
- Two recent observational studies conducted in intensive care units' in Europe and the United States observed that red blood cell (RBC) transfusions were administered in approximately 40% of all patients studied. (mednemo.it)
- Historically blood transfusion has been viewed as having obvious clinical benefit. (mednemo.it)
- [11-13] However, it has recently been recognized that the transfusion of blood and blood products increases the risk of critically ill patients developing delayed respiratory failure. (mednemo.it)
- Respiratory complications after blood transfusion consistent with the syndrome now known as TRALI have been reported since the 1950s. (mednemo.it)
- [13] to refer to pulmonary edema complicating blood transfusion. (mednemo.it)
- Great care must be taken to ensure that the correct blood product is delivered to the correct patient. (mhmedical.com)
- There are few indications for the use of whole blood transfusion. (mhmedical.com)
- 2.Refractory hypertension patients with hemodialysis treatment of refractory hypertension can be up to 50% (high renin type), and blood filtration treatment, can be reduced to 1%, some can stop using antihypertensive drugs. (dajimed.com)
- However, the virus can also be transmitted by transfusion of infected blood products or by solid organ transplantation. (cdc.gov)
- Respiratory examination revealed as a prophylaxis, blood transfusion and coides infection is intestinal obstruction, bilateral air entry with no added sounds analgesics. (who.int)
- Other modes of transmission for dengue virus are less common but include vertical transmission from a mother to a baby, blood transfusion or organ transplantation, needle stick, mucocutaneous exposure, or hospital or laboratory accidents, breast milk, and rarely, sexual transmission. (cdc.gov)
- Weak blood transfusion systems facilitate the spread of both hepatitis B and C virus infections. (bvsalud.org)
Hemoglobin2
- One unit of RBCs in an adult and 10mL/Kg in a pediatric patient will increase the hematocrit by approximately 3% or the hemoglobin by 1 g/dL in a normovolemic patient. (utmb.edu)
- oxygen delivery in healthy normovolemic patients can be maintained with hemoglobin levels as low as 7 grams/dL, although patients with comorbid conditions may require transfusion at higher levels of hemoglobin. (mhmedical.com)
Hematopoietic4
- To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
- Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)
- NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment. (umassmed.edu)
- vs., versus Characterization of HD/ASCT treatment according to the Baloxavir number of transplanted CD34+ cells To answer the clinically important question whether the number of transplanted CD34+ cells impacts hematopoietic reconstitution after HD/ASCT therapy and achieving homogenization, we focused on the first HD/ASCT therapy in the patients course of treatment (groups 1 and 2). (exposed-skin-care.net)
Granulocyte3
- There is limited data to suggest the benefit of granulocyte transfusion. (wikipedia.org)
- Experimental pneumonia due to Pseudomonas aeruginosa in leukopenic dogs: prolongation of survival by combined treatment with passive antibody to Pseudomonas and granulocyte transfusions. (umassmed.edu)
- Granulocyte transfusion in case of life-threatening situations when all other measures have failed. (lu.se)
TRALI2
- The incidence of TRALI is estimated to occur with1 in 4500-5000 transfusions and has a fatality rate of 5-50%, however patients may recover with appropriate supportive care. (cedars-sinai.edu)
- Even though our patient initially recovered from TRALI and got extubated, the ARDS recurred and progressed into pulmonary fibrosis. (cedars-sinai.edu)
Medicine and Hemotherapy1
- Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 47 (1): 14-22. (uni-giessen.de)
Risk of transfusion transmitte1
- Although the risk of transfusion transmitted infections has received considerable attention, [6] it is now becoming clear that there are other important, less recognized, risks of RBC transfusion related to RBC storage effects and to immunomodulating effects of RBC transfusions in almost all recipients. (mednemo.it)
Alloimmunization2
- SCA patients managed in a university hos- complicated by a high incidence of RBC pital in Saudi Arabia, in order to provide alloimmunization and other transfusion re- appropriate recommendations for the care lated complications [1-7]. (who.int)
- January 1996 to 31 December 2004 of the patients know the problems associated with transfusion history and medical files of alloimmunization, mainly the difficulty in 350 patients with SCA. (who.int)
Adhesion deficiency1
- Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
Regular transfusions2
- He needed regular transfusions every 25-30 days. (india4u.com)
- These regular transfusions can be associated with multiple health complications of their own, including problems in the heart, liver, and other organs due to an excessive build-up of iron in the body. (genengnews.com)
Complications3
- Chronic transfusion to decrease the frequency of alloimmuniza- therapy, which is being used with increas- tion and its related complications [2,11,12]. (who.int)
- Given the potential health complications associated with this serious disease, this action highlights the FDA's continued commitment to supporting the development of innovative therapies for patients who have limited treatment options. (genengnews.com)
- Data extracted included (i) patient demography (age and gender), (ii) clinical characteristics including vaccination status and presence of co-morbidities, (iii) clinical management including the use of sequential organ failure assessment (SOFA) scores, oxygen requirement, use of mechanical ventilation, and (iv) disease outcomes including length of hospital and intensive care unit (ICU) admission, recovery, complications with sequelae, or death. (bvsalud.org)
Graft versus2
- Leukoreduced RBCs still contain enough leukocytes capable of producing transfusion-associated graft versus host disease (TAGVHD) in susceptible patients. (utmb.edu)
- HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
Neutrophil1
- The leukocyte, neutrophil and platelet recovery over time was calculated and plotted using Kaplan-Meier survival analysis. (exposed-skin-care.net)
Infection3
- Investigate and analyze any suspected transfusion-transmitted infection cases to identify the source and prevent future occurrences. (researchgate.net)
- Additionally, Dr. Hendrickson has leadership and site director roles in three other COVID-19-related randomized controlled clinical trials studying anticoagulation strategies, anti-inflammatory medications, and novel cell-based therapy for patients hospitalized with SARS-CoV-2 infection. (ucsf.edu)
- In 1994, the U.S. Public Health Service (USPHS) and the Infectious Diseases Society of America (IDSA) recognized that, although strategies were available to reduce the frequency of opportunistic infections in patients who have human immunodeficiency virus (HIV) infection, information regarding prevention of both exposure and disease often was published in journals not regularly reviewed by health-care providers. (cdc.gov)
Refractory4
- We have observed significant responses to trametinib in patients with refractory PLGG in our institutions and results from the phase I study are promising. (biomedcentral.com)
- Group 1 includes NF1 patients with progressing/refractory glioma. (biomedcentral.com)
- Group 3 includes patients with progressing/refractory glioma with KIAA1549-BRAF fusion. (biomedcentral.com)
- Group 4 includes other patients with progressing/refractory glioma with activation of the MAPK/ERK pathway. (biomedcentral.com)
Febrile1
- the empirical treatment of presumed fungal infections in febrile neutropenic patients, where the fever has failed to respond to broad spectrum antibiotics and appropriate investigations have failed to define a bacterial or viral cause. (medicines.org.uk)
Pediatric1
- Characterization of pediatric transfusion-dependent thalassemia patients in a large academic center. (cdc.gov)
Infections6
- Report all cases of transfusion-transmitted infections promptly to the relevant public health authorities. (researchgate.net)
- In accordance with the research titled 'Transfusion Services in Tropical Africa: Challenges and Prospects from the Nigerian Perspective' conducted by Sagir Gumel Ahmed in 2022, unlike other routinely tested transfusion transmissible infections such as HIV, & hepatitis B and C viruses, Cytomegalovirus is said to be highly contagious and prevalent especially in developing countries such as Nigeria. (researchgate.net)
- In response, USPHS/IDSA developed comprehensive guidelines for health-care providers and patients that consolidated information pertaining to the prevention of opportunistic infections in persons infected with HIV. (cdc.gov)
- Initially this was driven by concerns over transfusion related infections, human immunodeficiency virus in particular. (mednemo.it)
- LAD1 patients have recurrent bacterial infections, impaired pus formation and impaired wound healing. (lu.se)
- Patients with some surface expression of CD18 (2,5-10%) have a moderate to mild phenotype with fewer serious infections and survival into adulthood. (lu.se)
Thalassemia patients2
- These cells produce higher levels of foetal haemoglobin (HbF), which can remove the need for transfusion in thalassemia patients and prevent vaso-occlusive crises in sickle cell patients. (pharmaceutical-technology.com)
- The trials met their primary endpoint with 16 out of 17 sickle cell patients showing freedom from vaso-occlusive crises and 24 out of 27 thalassemia patients being transfusion-independent for at least 12 consecutive months, as per a 9 June press release . (pharmaceutical-technology.com)
RBCs3
- In the absence of hemorrhage or active bleeding, the initial recommended dose is one unit for adults and 10mL/Kg for pediatrics with a reassessment post transfusion to determine the need for additional RBCs. (utmb.edu)
- In their study of 116 patients (51 males and 65 females) with thalassemia major, males were receiving more units of RBCs per transfusion and had a higher annual transfusion volume, but with correction for weight, females were receiving a higher transfused volume per kg: 225 versus 202 mL/kg in males ( P =0.028). (medscape.com)
- [4,5] On average, critically ill patients received almost 5 units of RBCs. (mednemo.it)
Iron chelation2
- Patients receiving long-term transfusion therapy also require iron chelation. (medscape.com)
- Vitamin C may improve iron excretion in patients receiving iron chelation, especially with deferoxamine. (medscape.com)
Require transfusion1
- Anemia may be cumulative and may require transfusion support. (nih.gov)
Bone marrow tra1
- The procedure is based on an autologous bone-marrow transplant (when patients receive a transplant of their own stem cells) and now constitutes a treatment option to cure an intestinal disease that sometimes does not successfully respond to drugs and requires highly complex surgery that does not provide a cure. (sciencedaily.com)
Recipients1
- In experienced centres, specific patient groups, such as those with cystic fibrosis (CF), can expect a median survival of well over 10 years with some recipients functioning well more than 20 years after their transplant. (ersjournals.com)
Diagnostic2
- A variety of diagnostic tests are prescribed for patients in order to detect various diseases. (biotechnology.report)
- Patients who meet the diagnostic criteria. (who.int)
Clinical8
- After more than a decade of research and clinical development, and through the perseverance of clinicians, patients, and their families, the approval of Zynteglo marks a watershed moment for the field of gene therapy. (genengnews.com)
- Dr. Hendrickson served as a site investigator to offer participation in clinical research studies and access to potential therapeutic agents for patients hospitalized at ZSFG. (ucsf.edu)
- [1] We report two cases of PG in a child and an adult patient, with variations in clinical presentation. (e-ijd.org)
- Clinical significance of mutational variants in beta and alpha genes in patients with hemoglobinopathies from two large Greek centers: a complex interplay between genotype and phenotype. (cdc.gov)
- This prospective, randomized, controlled clinical trial studied the rate of healing of postoperative hand wounds after a single application of leukocyte- and platelet-rich fibrin. (transfusionevidencelibrary.com)
- Exploratory, multicenter, controlled, randomized, double-blind clinical trial to evaluate the quality of life and safety of the nutritional supplement CARMINAL® in combination with conventional therapy vs. placebo in patients with ulcerative colitis in mild or moderate activity. (who.int)
- 4. Patient who is participating in another clinical trial or receiving another investigational product at the time of selection. (who.int)
- The duration of tuberculosis treatment depends on the regimen chosen, the patient's clinical and radiographical responses, smear and culture results, and susceptibility of Mycobacterium tuberculosis isolates from the patient or the suspected source case. (who.int)
Platelet count3
- There was a mean reduction of 1.1 x 109/l (P = 0.43) in the platelet count after transfusions of 2-3 units of leucocyte-depleted red cell concentrates (20 patients). (ox.ac.uk)
- However, there was a mean reduction of 2.7 x 109/l (P = 0.03), approximately 10%, in the platelet count after transfusions of non-leucocyte-depleted red cell concentrates (10 patients). (ox.ac.uk)
- 109/L as a variable for platelet engraftment, as the platelet count in some patients did not drop below 20? (exposed-skin-care.net)
Sickle cell di1
- Monitor for iron overload due to hemoglobinopathies such as sickle cell disease or thalassemia in chronically transfused patients. (medicinenet.com)
Organ1
- [ 16 ] This group's research documented a 90% long-term survival rate in patients with favorable characteristics (young age, HLA match, no organ dysfunction). (medscape.com)
Indications1
- Active hemorrhage resulting in shock is one of the few evidence-based established indications for transfusion. (medscape.com)
Anemia4
- Anemia in pregnancy and the puerperium should be treated according to a staged regimen, administering either iron alone or in combination with an off-label use of human recombinant erythropoietin in selected patients. (karger.com)
- The concept comprises early screening and treatment of anemia and iron deficiency, a transfusion and coagulation algorithm during delivery, as well as cell salvage. (karger.com)
- The peripheral smear report of the patient showed normocytic hypochromic anemia, neutrophilia with a mild shift to the left with thrombocythemia. (e-ijd.org)
- oxygen delivery to tissues, provide intravascular volume expansion, and to replace missing or depleted clotting factors in patients with clinically significant hemorrhage, anemia, thrombocytopenia or coagulopathy. (mhmedical.com)
Human1
- Our focus is on the relevance of Human Leucocyte Antigen (HLA) on transplant, transfusion and disease development. (bshi.org.uk)
Reduction2
- While not a curative option, ruxolitinib offers great palliative potential and results in significant reduction in splenomegaly and improvement in constitutional symptoms in the majority of treated patients, thus improving their quality of life and performance status. (cancernetwork.com)
- We are the Leukocyte Reduction Filter Manufacturer ,if you have any demand ,welcome to contact with us. (dajimed.com)
Chronic4
- Scientists are exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease which has considerable impact on the quality of life of the patients. (sciencedaily.com)
- In this line, Hospital Clínic, Barcelona is exploring an innovative cellular therapy that uses stem cells to treat Crohn's disease, a chronic genetic disease that affects 1% of the population in Spain and which has considerable impact on the quality of life of the patients. (sciencedaily.com)
- Ardelyx scores another FDA win after Xphyozah was approved last month as an add-on therapy for chronic kidney disease patients. (pharmaceutical-technology.com)
- Lung transplantation should be viewed as a potential treatment option for highly selected patients with very advanced chronic lung disease who continue to progress despite maximal medical therapy. (ersjournals.com)
Platelets1
- PCs contain leukocytes, which can pose potential side effects and activate platelets, reducing the efficacy of platelet transfusion. (phcogj.com)
Thrombocytopenic patients1
- The findings suggest that the forthcoming introduction of universal leucocyte depletion of red cell concentrates will minimize the worsening of thrombocytopenia that occurs in severely thrombocytopenic patients receiving standard non-leucocyte-depleted red cell concentrates. (ox.ac.uk)
Efficacy1
- I. To evaluate the efficacy of olaparib in two cohorts of patients with metastatic/advanced non prostate genitourinary (GU) cancer pre-selected by DNA-repair defects as measured by overall response rate (ORR). (bcan.org)
Patient's1
- Typically, a total treatment duration of 18-20 months and a treatment duration of 15-17 months after culture conversion are suggested for most patients, with the duration being modified according to the patient's response to therapy. (who.int)
Peripheral1
- The same pathway is also activated in plexiform neurofibromas (PNs) which are low-grade tumors involving peripheral nerves in patients with neurofibromatosis type 1 (NF1). (biomedcentral.com)
Therapy6
- Leukopheresis is the removal of PMNs, basophils, eosinophils for transfusion into patients whose PMNs are ineffective or where traditional therapy has failed. (wikipedia.org)
- In this article, we provide updated data on ruxolitinib therapy for patients with myelofibrosis and offer expert opinion on the appropriate use of this agent in the community practice. (cancernetwork.com)
- With this therapy, in an average follow-up period of 6 years, 80% of transplant patients are in a phase of total remission of the disease and the remaining 20% have shown considerable improvement following the transplant, and are now responding favorably to drugs. (sciencedaily.com)
- Dr. Julián Panés and Dr. Elena Ricart over the Gastroenterology Department of Hospital Clínic, Barcelona are the driving force behind this therapy in Spain and began to implement regenerative cellular therapy in patients with Crohn's disease in August 2008. (sciencedaily.com)
- To date, a total of 6 patients are benefiting from this new treatment, of whom 3 I've already completed the process and are in the follow-up face, and a further 3 are at different stages of therapy. (sciencedaily.com)
- 7. No other anti-cancer therapy (chemotherapy, immunotherapy, hormonal anti-cancer radiotherapy [except for palliative local radiotherapy]), biological therapy or other novel agent is permitted while the patient is receiving study medication. (astrazenecaclinicaltrials.com)
Hemostasis1
- The correct diagnosis and treatment of these patients depend on the knowledge of normal hemostasis mechanisms and the results of laboratory tests that evaluate these mechanisms. (bvsalud.org)
Cytokine1
- Secondary endpoints were systemic cytokine concentrations, leukocyte counts, and the phagocytic activity of granulocytes and monocytes. (asahq.org)
Mortality5
- Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
- To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
- Honig LS, Kang MS, Schupf N, Lee JH, Mayeux R. Association of shorter leukocyte telomere repeat length with dementia and mortality. (jamanetwork.com)
- Recurrence and mortality rates were significantly different between transfusion and no-transfusion groups, in favour of the no-transfusion group. (bvsalud.org)
- Majority (74.8%, 199/266) of the patients were discharged without sequelae, 0.8% (2/266) were discharged with sequalae from one study, and mortality of 1.9% (5/266) was reported, also from one study. (bvsalud.org)
Pulmonary1
- When successful, the procedure is also associated with a marked improvement in quality of life and a proven survival advantage in patients with CF, idiopathic pulmonary fibrosis and pulmonary hypertension. (ersjournals.com)
Hemorrhage3
- Patients with a history of hematoma or hemorrhage are a frequent problem in emergency rooms. (bvsalud.org)
- The present paper reports the case of a patient whose promyelocytic leukemia was diagnosed after hemorrhage resulting from the simple extraction a tooth. (bvsalud.org)
- Patient APO, a 43 year-old male, was admitted to the emergency room of Hospital da Restauração Recife/PE, Brazil, presenting alveolar hemorrhage after the extraction of an inferior canine tooth. (bvsalud.org)
Filtration1
- The leucodepletion process can be carried out by filtration to reduce the leukocyte count. (phcogj.com)
Anaemia2
- If you have sickle cell disorder, thalassemia or another inherited anaemia, please see our frequently asked questions for patients . (nhsbt.nhs.uk)
- Rare inherited anaemias include Diamond-Blackfan anaemia (DBA), congenital dyserythropoietic anaemias (CDA), congenital sideroblastic anaemias (CSA), and disorders of red cell membrane and enzymes, such as hereditary spherocytosis and pyruvate kinase deficiency (if transfusion dependent). (nhsbt.nhs.uk)
Transplant6
- The transplant requires several weeks of admission to hospital before patients receive their own cells. (sciencedaily.com)
- in Italy, the treatment has been applied to 4 patients, 3 of whom are also showing excellent progress following the transplant. (sciencedaily.com)
- Given the age of the patient, it was definitely a high-risk challenging case with very less success rate," said Dharma Choudhary who supervised the team of doctors who performed the transplant. (india4u.com)
- What does lung transplant offer patients with advanced lung disease? (ersjournals.com)
- Identifying those patients with end-stage lung disease who might benefit from lung transplant and referring them promptly for specialist assessment is very important. (ersjournals.com)
- Referring clinicians play an essential role in identifying patients who might benefit, but equally need to avoid overwhelming transplant centres with inappropriate referrals which would limit the effectiveness of the centre to assess and list in a timely manner those most likely to benefit. (ersjournals.com)
Neutrophils1
- The leucocyte count was normal with a differential of 65% neutrophils, 30% lymphocytes and 5%monocytes. (ispub.com)