AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
Klebsiella pneumoniaeKlebsiella InfectionsStreptococcus pneumoniaeMycoplasma pneumoniaebeta-LactamasesKlebsiella oxytocaMicrobial Sensitivity TestsAnti-Bacterial AgentsCarbapenemsbeta-Lactam ResistanceEnterobacteriaceaeBacterial ProteinsNitrogenaseLiver AbscessNitrogen FixationDrug Resistance, Multiple, Bacterialbeta-LactamsDNA, BacterialDrug Resistance, BacterialEscherichia coliEnterobacteriaceae InfectionsPlasmidsGenes, BacterialCephalosporinsCross InfectionPneumonia, MycoplasmaEnterobacterGram-Negative BacteriaCeftazidimePneumonia, BacterialPneumococcal InfectionsLiver Abscess, PyogenicBacterial CapsulesMolybdoferredoxinMolecular Sequence DataElectrophoresis, Gel, Pulsed-FieldConjugation, GeneticKlebsiellaChlamydophila InfectionsBacteremiaThienamycinsCefotaximeAnti-Infective AgentsAcetyleneImipenemGram-Negative Bacterial InfectionsCephalosporin ResistanceHospitalsColistinPolymerase Chain ReactionSequence Analysis, DNAPolysaccharides, BacterialDrug Resistance, MicrobialEnterobacter cloacaeMultilocus Sequence TypingPneumonia, PneumococcalMinocyclineEscherichia coli InfectionsCefoxitinEnterobacter aerogenesProteus mirabilisIsoelectric FocusingBase SequenceBacterial InfectionsSerotypingFluoroquinolonesQuinolonesPenicillanic AcidGram-Positive BacteriaBacteriaMolecular TypingCiprofloxacinPenicillin ResistancePiperacillinAntibodies, BacterialPorinsGreeceColony Count, MicrobialPenicillinsPseudomonas aeruginosaGene Expression Regulation, BacterialDisease OutbreaksAmino Acid SequenceAzotobacterBacteriological TechniquesCulture MediaAztreonamOperonMutationMolecular EpidemiologyBacterial Typing TechniquesDisk Diffusion Antimicrobial TestsUrinary Tract InfectionsClavulanic AcidCloning, MolecularDNA FingerprintingO AntigensPropanediol DehydrataseSerratia marcescensCommunity-Acquired Infections
IsolatesInfectionsCarbapenemaseStreptococcusEscherichiaPrevalenceBacteriaPseudomonasInclude Klebsiella pneumoniaeMultidrug-resistantAntibioticsInfectionSpeciesEnterobacteriaceaeStrainsPneumoniaBacterialAntibiotic resistanceSusceptibilitySputumEndogenous endophthalmitisBacteremiaCarbapenem-susceptibleColonizationResistanceIsolateClonalOutbreakSepsisRespiratorySevere2016AcuteAnkylosing spondylitisVirulenceMolecularExtended-spectrumForm of bronchopneumoniaPathogensOpportunistic pathogenRectalNosocomialDiabeticPediatricGenusIncidencePulmonaryIntensiveMortalityDiagnosisGenital
Isolates26
  • Resistant Plasmid ducing K. pneumoniae isolates are identifi ed. (cdc.gov)
  • The KPC-3 plasmid was cystitis developed, and the patient underwent cholecys- identical in isolates of both species. (cdc.gov)
  • We examined the clinical data from patients with CPE infections and their outcomes, concentrating on Klebsiella pneumoniae isolates. (biomedcentral.com)
  • Altogether, 88.9% (40/45) of the CPE isolates were K. pneumoniae . (biomedcentral.com)
  • The most abundant carbapenemase gene family in the K. pneumoniae isolates (33/39) was bla OXA-232 , with bla NDM-1 additionally identified in 19 of them. (biomedcentral.com)
  • Here, we analysed the genetic diversity of an ST512 K. pneumoniae population in a single patient.Twelve K. pneumoniae isolates (n = 5 from urine samples and n = 7 from rectal swabs) were recovered from one patient over a 2 month period. (pasteur.fr)
  • The first K. pneumoniae isolate, D1, was used as a reference for phylogenetic analysis.Antimicrobial susceptibility testing, plasmid analysis and WGS revealed concomitant carriage of carbapenem-resistant and carbapenem-susceptible K. pneumoniae isolates of ST512, with the absence of the entire blaKPC-carrying plasmid in the susceptible population. (pasteur.fr)
  • This study focused on the isolation and identification of K. pneumoniae isolates from patients with urinary tract infections. (annalsofrscb.ro)
  • 62 isolates (32 women, 30 men) of K. pneumoniae clinical specimens of mid-stream urine were collected from three hospitals in Baghdad. (annalsofrscb.ro)
  • Umar, U. , Anagor, S. , Aliyu, A. and Suleiman, A. (2016) Hypermucoviscosity in Clinical Isolates of Klebsiella pneumoniae Correlates with High Multiple Antibiotic Resistance (MAR) Index. (scirp.org)
  • The goals of the study were to investigate the virulence factors of hypermucoviscosity phenotype and rmpA gene among the K. pneumoniae isolates causing alcoholic pneumonia and to evaluate the clinical characteristics of these patients. (tmu.edu.tw)
  • However, isolates with the virulence factors were not significantly associated with severity and mortality of the infected patients. (tmu.edu.tw)
  • Conclusion: We confirmed that the virulence factors were highly prevalent in the K. pneumoniae isolates causing alcoholic pneumonia. (tmu.edu.tw)
  • Multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates harboring New Delhi metallo-β-lactamase (NDM-1) were isolated from a patient who had returned to Canada from India. (flutrackers.com)
  • Methods Six hundred and forty-seven K. pneumoniae isolates (2008-2017) with reduced susceptibility to carbapenems were screened for blaBKC-1. (cardiff.ac.uk)
  • PCR and sequencing identified NDM-1 and OXA-232, a 5-aa variant of OXA-48 recently reported in K. pneumoniae isolates from India ( 9 ). (blogspot.com)
  • All K. pneumoniae and E. coli isolates remained susceptible to fosfomycin and colistin. (blogspot.com)
  • The patient did not receive any antimicrobial drug therapy specific for these isolates because she was deemed to be only colonized with them in the urine. (blogspot.com)
  • Aspiration of the abscess revealed a purulent polymycrobial fluid with isolates of two morphotypes of Klebsiella pneumoniae, Enterococcus faecium, and Candida albicans. (ispub.com)
  • 2020) Antibiotic susceptibility patterns of bacteria isolates from post-operative wound infections among patients attending Mama Lucy Kibaki Hospital, Kenya. (ac.ke)
  • In this study, we molecularly characterized 12 NDM-1 producing clinical Enterobacteriaceae ( Klebsiella pneumoniae , Escherichia coli , Enterobacter cloacae ) isolates that were part of a collection of non-carbapenem susceptible isolates obtained during a one-year period. (who.int)
  • The isolates appear clonally unrelated with MLST, revealing a diversity of clonal types among the Klebsiella pneumoniae and Escherichia coli isolates. (who.int)
  • The first carbapenem-resistant NDM-1 isolates characterized in 2009 were Klebsiella pneumoniae and Escherichia coli isolated from a Swedish patient who had sought medical care in New Delhi, India. (who.int)
  • The 52 isolates comprised the following species: 31 Klebsiella pneumoniae , 13 Escherichia coli , seven Enterobacter cloacae and one Enterobacter aerogenes . (who.int)
  • Two of these isolates (594 and 693) were obtained from the same patient but from different collection sites ( Table 1 ). (who.int)
  • Out of 4014 enterobacteria isolates as cause of urinary infection included, 3224 (80.3%) were from ambulatory samples and 790 (19.7%) from hospitalized patients. (bvsalud.org)
Infections41
  • The clinical characteristics of 33 hospitalised patients with confirmed CPE, including patient-related factors associated with the development of CPE infections, were examined. (biomedcentral.com)
  • Among the CPE-infected patients ( n = 18) and CPE-colonised patients who developed CPE infections during the study ( n = 3), all but one received standard colistin-based combination therapy. (biomedcentral.com)
  • This type of multi-layered analysis can be further exploited in Thailand and elsewhere to modify the regimes used for empirical antibiotic treatment and improve the management strategies for CPE infections in hospitalised patients. (biomedcentral.com)
  • On September 17, 2021, an Idaho hospital (hospital A) Treatment of carbapenemase-producing carbapenem-resis- collected sputum by endotracheal tube aspiration of a woman tant Pseudomonas aeruginosa (CP-CRPA) infections is chal- aged 50-65 years (patient 1), who received mechanical ven- lenging because of antibiotic resistance. (cdc.gov)
  • In recent years, Klebsiella species have become important pathogens in nosocomial infections. (wikipedia.org)
  • In addition to pneumonia, Klebsiella can also cause infections in the urinary tract, lower biliary tract, and surgical wound sites. (wikipedia.org)
  • Klebsiella ranks second to E. coli for urinary tract infections in older people. (wikipedia.org)
  • Results indicate that hospitalized patients become infected with their colonizing strains, supporting the strong association between colonization and bloodstream infections. (amr-insights.eu)
  • K. pneumoniae causes suppurative infections, bacteremia and septicaemia. (scirp.org)
  • The bacteria accounts for a great majority of hospital associated infections in neonates, immunocompromised patients, patients undergoing respiratory therapies and patients hospitalized in urology and burn wards. (scirp.org)
  • Example of serious community associated infections due to K. pneumoniae is Friedlander's pneumonia, a severe form of lobar pneumonia with high mortality, and in some countries the organism is the leading cause of pneumonia. (scirp.org)
  • In the infected site of lung caused by Klebsiella pneumoniae, inadequate lymphocyte recruitment links to weaken clearance of K. pneumoniae from lung infections, thus leading to severe pneumonia. (tmu.edu.tw)
  • The intestinal inhabitant Klebsiella pneumoniae is one of the most dreaded hospital germs, as it can cause severe pneumonia, urinary tract infections or even sepsis in weakened patients. (eurekalert.org)
  • Sections on the prevention of bacterial pneumonia in mechanically ventilated and/or critically ill patients, care of respiratory-therapy devices, prevention of cross-contamination, and prevention of viral lower respiratory tract infections (e.g., respiratory syncytial virus {RSV} and influenza infections) have been expanded and updated. (cdc.gov)
  • Traditional preventive measures for nosocomial pneumonia include decreasing aspiration by the patient, preventing cross-contamination or colonization via hands of personnel, appropriate disinfection or sterilization of respiratory-therapy devices, use of available vaccines to protect against particular infections, and education of hospital staff and patients. (cdc.gov)
  • Klebsiella pneumoniae ( K. pneumoniae ) causes a wide range of infections, including pneumonia, urinary tract infections, bacteremia and liver abscesses, and mainly infects immunocompromised people. (krqe.com)
  • The incidence of K. pneumoniae resistances is evaluated between 90-100,000 patients in the US and EU5 2 , mainly in Urinary Tract infections and Respiratory Tract infections. (krqe.com)
  • A total of 23 sJIA patients (13 males, median age 8.2), 20 acute lymphoblastic leukemia (ALL) patients, 18 patients with severe infections (SIF), 26 Kawasaki disease (KD) patients, 18 juvenile idiopathic arthritis (JIA) patients, and 25 healthy control patients were selected for this study. (scielo.br)
  • In the present study, the serum concentrations of IL-6, IL-18, S100A8, and S100A9 were measured and comparatively analyzed in pediatric patients with sJIA and other diseases that can be easily misdiagnosed as sJIA, including acute lymphoblastic leukemia (ALL), severe infections (SIF), KD, and juvenile idiopathic arthritis (JIA) with multiple joint involvement. (scielo.br)
  • Patients with these infections have similar presentations to those with infections caused by other organisms. (medscape.com)
  • Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
  • Patients have leukocytosis , recurrent infections (more prominent in infants and toddlers), and severe growth and mental retardation . (medscape.com)
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
  • The infections in patients with SLE, primarily involving the skin, respiratory tract, and urinary tract, can significantly complicate disease management. (medscimonit.com)
  • This study aimed to evaluate the occurrence, management, and patient outcomes associated with infections in a group of 74 SLE patients at a single center in Saudi Arabia, spanning a 5-year period. (medscimonit.com)
  • All adult SLE patients (age >14 years, as per hospital policy), confirmed by SLICC criteria, and admitted due to infections (determined by quick Sequential Organ Failure Assessment or qSOFA scores) were included in the study. (medscimonit.com)
  • C. difficile has become a scourge of hospitals and infection is often made possible when patients are heavily treated with antibiotics to fight other infections. (pakalertpress.com)
  • Hospital-acquired acute infections are more often bacterial, typically involving Staphylococcus aureus , Klebsiella pneumoniae , Pseudomonas aeruginosa , Proteus mirabilis, and Enterobacter . (msdmanuals.com)
  • Invasive Sinusitis in Immunocompromised Patients Sinusitis is inflammation of the paranasal sinuses due to viral, bacterial, or fungal infections or allergic reactions. (msdmanuals.com)
  • Fungal infections ( Aspergillus , Sporothrix , Pseudallescheria ) may be chronic and tend to strike older and immunocompromised patients. (msdmanuals.com)
  • However, a significant difference in death rates was not detected between the 2 compared groups in studies reporting on patients with undetermined infections, patients with infections other than bacteremia, or patients among whom the percentage of bacteremia cases was low. (cdc.gov)
  • Therefore, it could be suggested that the higher rate of death among patients with CRE infections, compared with CSE infections, is due to the higher rate of death among patients with bacteremia caused by CRE. (cdc.gov)
  • Many factors other than underlying concurrent condition or severity of illness at the initial medical visit could be responsible for the higher rate of death among patients with infections caused by CRE. (cdc.gov)
  • Those studies showed that patients with infections caused by CRE were significantly more likely than those infected by CSE to receive inappropriate antibiotic treatment. (cdc.gov)
  • Njoroge Gender and Socal-demographic factors of urinary tract infections among diabetic patients in Kisii referral Hospital, Kenya. (ac.ke)
  • The mcr-1 gene makes bacteria resistant to the antibiotic colistin, which is used as a last-resort drug to treat patients with infections caused by multidrug-resistant bacteria, including carbapenem-resistant Enterobacteriaceae (CRE). (cdc.gov)
  • For example, Escherichia coliurinary tract infections, and respiratory infections by Streptococcus pneumoniae or Haemophilus influenzae may not respond to antibiotics commonly used and require the use of more complex and expensive treatments. (paho.org)
  • The cost of health care for patients with resistant infections is higher than care for patients with non-resistant infections due to longer duration of illness, additional tests and use of more expensive drugs. (paho.org)
  • The study findings demonstrate the potential value of the V. corymbosum extract as an alternative treatment for K. pneumoniae infections. (blueberry.org)
  • This study aimed to identify the effect of multidrug-resistant microorganism (MDRO) infections before LT on survival after LT. METHODS: Retrospective study that included patients who underwent LT between 2010 and 2019. (bvsalud.org)
  • 351 infections were identified in 259 (30%) patients, of whom 75 (29%) had ≥1 pre-LT MDRO infection. (bvsalud.org)
Carbapenemase10
  • Klebsiella pneumoniae carbapenemase (KPC) 3-pro- below the knee. (cdc.gov)
  • Phylogenetic analysis revealed the polyclonal spread of carbapenemase-producing K. pneumoniae (CPKP) within the patient population, with the following two major subclades identified: ST16 ( n = 15) and ST231 ( n = 14). (biomedcentral.com)
  • However, a survey from the National Antimicrobial Resistance Surveillance, Thailand from 2008 to 2016 revealed that carbapenemase-producing Klebsiella pneumoniae (CPKP) had increased in prevalence from 0.4% in 2008 to 5.4% in 2016 [ 3 ]. (biomedcentral.com)
  • Dipòsit Digital de la Universitat de Barcelona: CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3. (ub.edu)
  • CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3. (ub.edu)
  • CARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain. (ub.edu)
  • The most concerning carbapenem resistance mechanism corresponds to carbapenem-inactivating beta-lactamases, especially the K. pneumoniae carbapenemase (KPC) distributed worldwide, showing the highest prevalence. (biorxiv.org)
  • Objective To describe the undetected circulation of an epidemic BKC-1-producing Klebsiella pneumoniae ST442 clone, occasioning the first reported outbreak of the infrequent carbapenemase BKC-1. (cardiff.ac.uk)
  • However, in the United States, Klebsiella pneumoniae carbapenemase (KPC)-type β-lactamase is the most common carbapenemase among Enterobacteriaceae , especially K . pneumoniae . (blogspot.com)
  • Among the known carbapenemases are Klebsiella pneumoniae carbapenemase, or KPC, and Verona integrin-encoded metallo-Beta-lactamase, or VIM. (cdc.gov)
Streptococcus4
Escherichia4
  • to Escherichia coli The Study in Patient In April 2008 a carbapenem-nonsusceptible E. coli strain, marked as Eco2, was recovered from the gall blad- der drainage of a 91-year-old man with dialysis-dependent end-stage renal disease, congestive heart failure, anemia, Moran G. Goren, Yehuda Carmeli, and peptic ulcer disease. (cdc.gov)
  • The patient was treated with ertapenem, ducing Escherichia coli was isolated from a carrier of KPC- metronidazole, colistin, and vancomycin. (cdc.gov)
  • New Delhi metallo-β-lactamase in Klebsiella pnemoniae and Escherichia coli, Canada. (flutrackers.com)
  • We report K. pneumoniae co-producing NDM-1 and OXA-232, a variant of OXA-48, and Escherichia coli producing NDM-1 that were isolated from the same patient. (blogspot.com)
Prevalence7
  • A K. pneumoniae prevalence of 24% (15/62) was obtained of which 47% (7/15) were mucoid (hypermucoviscous) and 53% (8/15) were non-mucoid. (scirp.org)
  • Future prevalence of colonization with extended-spectrum betalactamase (ESBL-) producing K. pneumoniae in humans and the potential of public health interventions against the spread of these resistant bacteria remain uncertain. (biomedcentral.com)
  • To what extent antimicrobial consumption and local and external sources of colonization have contributed to the spread of ESBL-producing K. pneumoniae, and the magnitude of their effect on the future prevalence of colonization with this pathogen, is not yet understood. (biomedcentral.com)
  • This study aimed to compare the effect of different types of public health interventions on the future course of prevalence of colonization with ESBL-producing K. pneumoniae . (biomedcentral.com)
  • Prevalence of glaucoma in patients suffering from. (annals.edu.sg)
  • Mumbo MT, Nyaboga EN, Kinyua J, Muge EK, Mathenge SGK , Muriira G, Rotich H, Njiraini B and Njiru JM (2023) Prevalence and antimicrobial resistance profile of bacterial foodborne pathogens in Nile tilapia fish (Oreochromis niloticus) at points of retail sale in Nairobi, Kenya. (ac.ke)
  • Prevalence of Klebsiella pneumoniae among patients attending Africa Inland Church Hospital Kijabe, Kenya. (ac.ke)
Bacteria13
  • Also, the use of antibiotics can be a factor that increases the risk of nosocomial infection with Klebsiella bacteria. (wikipedia.org)
  • The most common condition caused by Klebsiella bacteria outside the hospital is pneumonia, typically in the form of bronchopneumonia and also bronchitis. (wikipedia.org)
  • Klebsiella pneumoniae is a gram negative bacteria and an opportunistic pathogen. (scirp.org)
  • FES patients showed significantly higher IgA to C1q, cadherin, catenin, plasmalemma vesicle-associated protein , and IgA/IgM to Gram-negative bacteria than FES patients and controls. (immunoscienceslab.com)
  • K. oxytoca can specifically force out multiresistant K. pneumoniae bacteria because it effectively blocks the niche to be occupied by the hospital germ", explains Strowig. (eurekalert.org)
  • First we wanted to find out how susceptible healthy adults and children are to colonisation with multi-resistant K. pneumoniae bacteria", says lead author Lisa Osbelt to explain the study approach. (eurekalert.org)
  • Most bacterial nosocomial pneumonias occur by aspiration of bacteria colonizing the oropharynx or upper gastrointestinal tract of the patient. (cdc.gov)
  • K. pneumoniae bacteria represents a new target with a high medical need, affecting a large population worldwide, and for which antibiotics offer only a limited therapeutic solution. (krqe.com)
  • Also, SATURN had as mission to improve methodological standards and conduct research to better understand the impact of antibiotic use on acquisition, selection and transmission of antibiotic-resistant bacteria (ARB) in different environments, by combining state-of-the-art analyses of molecular, ecologic and individual patient-level data. (europa.eu)
  • Sera were tested either unabsorbed or following absorption with whole Klebsiella pneumoniae bacteria. (bmj.com)
  • It can cause unstoppable diarrhea and the latest treatment doesn't even involve antibiotics, but a transplant of so-called good bacteria from healthy patients. (pakalertpress.com)
  • Healthcare providers should follow Standard and Contact Precautions ( https://www.cdc.gov/hicpac/2007IP/2007ip_part3.html ) for any patients colonized or infected with antibiotic resistant bacteria, including patients who are found to have mcr-1 mediated resistant organisms. (cdc.gov)
  • BACKGROUND: Our aim in this retrospective cohort study was to assess the impact on mortality of the empirical use of polymyxin as therapy for carbapenem-resistant gram-negative bacteria (CR-GNB) in septic patients. (bvsalud.org)
Pseudomonas1
Include Klebsiella pneumoniae1
Multidrug-resistant4
  • It is indicated for community-acquired pneumonia, including multidrug-resistant S pneumoniae . (medscape.com)
  • Multidrug-resistant (MDR) and hypervirulent Klebsiella pneumoniae , particularly carbapenem-resistant strains (CR- Kp ) causing high mortality and morbidity, are critical concerns[ 1 ]. (biorxiv.org)
  • The extract significantly inhibited biofilm formation and bacterial adhesion to HT-29 colorectal cells by a highly adherent multidrug-resistant K. pneumoniae. (blueberry.org)
  • At baseline, both screening test results were not reported, and patients were put under contact precautions (CP) based on previous colonization or infection by multidrug-resistant organisms. (bvsalud.org)
Antibiotics5
  • The patient was treated with intravenous antibiotics, and total parenteral nutrition to provide bowel rest, and CT guided percutaneous drainage. (ispub.com)
  • All patients treated with antibiotics experienced a new UTI during the scoring period of 12 months, being 19 days the median number of days free of UTIs (range 5-300). (frontiersin.org)
  • The E. coli isolate from the patient was also resistant to antibiotics in at least five additional antibiotic classes, including cephalosporins, fluoroquinolones, sulfonamides, aminoglycosides, and tetracyclines. (cdc.gov)
  • In settings where a prescription is required to access antibiotics, the prescriber-patient encounter is a logical target for improving appropriate use. (hindawi.com)
  • BACKGROUND: Cirrhotic patients are highly exposed to healthcare services and antibiotics. (bvsalud.org)
Infection16
  • During his hospital stay, the patient underwent contained a carbapenem-susceptible E. coli strain isogenic screening for carriage of carbapenem-resistant Enter- with the KPC-3-producing isolate, which suggests horizon- obacteriacae (CRE) as part of a routine infection control tal interspecies plasmid transfer. (cdc.gov)
  • Infection with carbapenem-resistant K. pneumoniae is as- genes, plasmid isolation, transformation, and Southern sociated with an increased proportion of deaths compared analysis) were performed as described ( 2,4,7 ). (cdc.gov)
  • Health Laboratory (UPHL), and CDC was undertaken to No patients were placed in room X after the second clinical identify the etiology of the infection. (cdc.gov)
  • Although patients receiving mechanically assisted ventilation do not represent a major proportion of patients who have nosocomial pneumonia, they are at highest risk for acquiring the infection. (cdc.gov)
  • In Western countries, we estimate that between 3% and 5% of pneumonias are linked to an infection caused by K. pneumoniae . (krqe.com)
  • In high-risk patients (alcoholics and septicemics), the mortality rate associated with this kind of infection is between 50 and 100% 1 . (krqe.com)
  • The presence of invasive devices in hospitalized patients greatly increases the likelihood of infection. (medscape.com)
  • As for OXA-48-group β-lactamase, 2 cases of infection with OXA-48-producing K. pneumoniae were recently reported from Virginia ( 7 ). (blogspot.com)
  • In the early days of the pandemic when information on COVID-19 infection was lacking, all COVID-19 positive patients were admitted into acute hospitals for. (annals.edu.sg)
  • is an aggressive, sometimes fatal, infection in immunocompromised patients, usually caused by Aspergillus or Mucor species. (msdmanuals.com)
  • 718 patients, along with the considerable heterogeneity among the included studies, but not among the type of infection, may justify the absence of statistical significance. (cdc.gov)
  • Antibiotic Susceptibility Pattern among Male Patients with Urinary Tract Infection in Special Treatment Centre Nairobi County, Kenya. (ac.ke)
  • This strain, responsible for a large outbreak of infection in Spain, was selected on the basis of its remarkable capacity to colonize the gastrointestinal tract of patients. (blueberry.org)
  • Compared to survivors, non-survivors were older patients, non-insured, had a higher frequency of hypertension, diabetes, heart disease, and were more prone to suffer from a severe form of COVID-19 infection. (bvsalud.org)
  • Clinical charts of ambulatory and hospitalized patients diagnosed with urinary infection at the Central Hospital of IPS from March 2015 to August 2016were retrospectively reviewed. (bvsalud.org)
  • Which postop patients are at the highest risk of developing a hospital-acquired C. diff infection? (medscape.com)
Species7
  • In humans K. pneumoniae is an important species of medical importance of the genus Klebsiella and is found as saprophyte in the nasopharynx and in the gastrointestinal tract. (scirp.org)
  • Some encapsulated Klebsiella species form glistening mucoid colonies of viscid consistency. (scirp.org)
  • This species, identified as Klebsiella oxytoca , uses the same sugars as the pathogen, but it does it more efficiently so that there is not enough left for the pathogen to survive. (eurekalert.org)
  • These three species were endemic in the ICU with a few clones circulating among ICU patients and the environment. (eur.nl)
  • Most reports to date have identified the mcr-1 gene in E. coli , but it has also been reported from Salmonella species, Shigella sonnei , and Klebsiella pneumoniae . (cdc.gov)
  • Thirty-four extracts from 13 South African plant species traditionally used for the treatment of inflam mation were investigated for their ability to control a microbial trigger for ankylosing spondylitis ( Klebsiella pneumoniae ). (springer.com)
  • Conclusion: The results support the traditional use of anticancer species as nutritional and dietary supplements, whose bioactive compounds are relevant in managing cancer patients. (who.int)
Enterobacteriaceae2
Strains4
  • citation needed] New antibiotic-resistant strains of K. pneumoniae are appearing. (wikipedia.org)
  • In collaboration with partners in Magdeburg and Hannover, the HZI department led by Till Strowig, was able to isolate strains of a related bacterium from the intestine that are highly effective against K. pneumoniae . (eurekalert.org)
  • Recent studies in Europe and the United States 3 , 4 also revealed the existence of K. pneumoniae strains with an exceptionally high level of antimicrobial resistance, making them even more difficult to treat. (krqe.com)
  • This level of antimicrobial resistance in K. pneumoniae strains had never been observed before. (krqe.com)
Pneumonia9
  • The term "typical" CAP refers to a bacterial pneumonia caused by pathogens such as S pneumoniae , H influenzae , and M catarrhalis . (medscape.com)
  • Community-acquired pneumonia caused by Klebsiella pneumoniae may occasionally be called Friedländer's pneumonia. (wikipedia.org)
  • In terms of the pathophysiology of Klebsiella pneumonia the neutrophil myeloperoxidase defense against K. pneumoniae is often seen. (wikipedia.org)
  • Therefore, alcoholic patients with K. pneumoniae pneumonia are highly fatal. (tmu.edu.tw)
  • Material and Methods: The alcoholic patients admitted to intensive care units (ICUs) with K. pneumoniae pneumonia were enrolled. (tmu.edu.tw)
  • However, these virulence factors of the causative organisms did not further contribute to the disease severity and mortality of alcoholic patients with K. pneumoniae pneumonia. (tmu.edu.tw)
  • Because intubation and mechanical ventilation alter first-line patient defenses, they greatly increase the risk for nosocomial bacterial pneumonia. (cdc.gov)
  • Worldwide, K. pneumoniae is responsible for 11.8% of hospital-acquired pneumonia. (krqe.com)
  • ABSTRACT This study evaluated the role of periodontal pathogens in 50 hospitalized patients with hospital- acquired pneumonia compared with 30 healthy controls. (who.int)
Bacterial5
  • The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)
  • found an association between high levels of carbapenem-resistant Klebsiella pneumoniae in the gut microbiome and an increased risk of bacteremia, suggesting either bacterial translocation from the gut into the bloodstream or a tendency for this dominant state to lead to skin contamination resulting in catheter-associated bacteremia. (cdc.gov)
  • In the group treated with the bacterial preparation, 35 (9.7%) patients experienced an UTI in the same period. (frontiersin.org)
  • Randomized, double-blind and placebo-controlled, clinical trials are needed to establish, more accurately, the clinical impact of this bacterial preparation in patients with rUTIs. (frontiersin.org)
  • Antibiotic sensitivity patterns showed concordance of bacterial cultures from dental plaque and oropharyngeal cavity in 13 patients. (who.int)
Antibiotic resistance2
  • ANRESIS prospectively collects routine and patient-specific antibiotic resistance data representing around 80% of annual hospitalization days across Switzerland. (biomedcentral.com)
  • These results provide baseline knowledge for the detailed understanding of molecular and genetic determinants behind antibiotic resistance and virulence of K. pneumoniae in Chile and South America. (biorxiv.org)
Susceptibility1
Sputum2
  • Patients with typical CAP classically present with fever, a productive cough with purulent sputum, dyspnea, and pleuritic chest pain. (medscape.com)
  • Individuals with Klebsiella pneumoniae tend to cough up a characteristic sputum, as well as having fever, nausea, tachycardia, and vomiting. (wikipedia.org)
Endogenous endophthalmitis1
Bacteremia2
  • Five patients had concurrent K. pneumoniae bacteremia. (tmu.edu.tw)
  • A critical finding of our metaanalysis is that the number of deaths was 2-fold higher among patients with bacteremia caused by CRE than among patients with bacteremia caused by CSE. (cdc.gov)
Carbapenem-susceptible1
  • The car- to carbapenem-susceptible K. pneumoniae ( 5 ). (cdc.gov)
Colonization2
  • Therefore, it is likely that the patient was already colonized by NDM-1-producing E. coli ST95 at the time of the first admission, but this colonization was not detected in a clinical culture at that time. (blogspot.com)
  • The present study investigated the anti-adhesive and anti-biofilm activity of a saline extract of blueberry (Vaccinium corymbosum) targeting intestinal colonization by a highly adherent Klebsiella pneumoniae strain. (blueberry.org)
Resistance2
  • Multidrug and carbapenem-resistant K. pneumoniae (CR- Kp ) are considered critical threats to global health and key traffickers of resistance genes to other pathogens. (biorxiv.org)
  • Ashayeri-Panah M, Feizabadi MM, Eftekhar F (2014) Correlation of multi-drug resistance, integron and blaESBL gene carriage with genetic fingerprints of extended-spectrum β-lactamase producing Klebsiella pneumoniae . (springer.com)
Isolate1
  • The isolate belonged to sequence type (ST) 14, as determined by multilocus sequence typing, and has been reported to be common among NDM-1-producing K. pneumoniae in Europe ( 10 ). (blogspot.com)
Clonal1
Outbreak1
Sepsis1
Respiratory5
  • Fever with associated respiratory distress or air hunger occurs in most patients. (medscape.com)
  • This patient population is believed to have impaired respiratory host defenses, including persons with diabetes, alcoholism, malignancy, liver disease, chronic obstructive pulmonary diseases, glucocorticoid therapy, kidney failure, and certain occupational exposures (such as papermill workers). (wikipedia.org)
  • neonatal ward devices, respiratory support equipment, and urinary catheters put patients at increased risk. (wikipedia.org)
  • All patients needed mechanical ventilator for respiratory support. (tmu.edu.tw)
  • Patients present with a purulent nasal discharge with crusting and nodule formation that leads to respiratory obstruction. (medscape.com)
Severe3
  • 4 - 7 Up to 35% of patients with uveitis have severe visual impairment, and roughly 10% are legally blind. (aafp.org)
  • This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
  • The patient is unable to bear weight secondary to the severe pain. (ispub.com)
20163
  • A recent retrospective cohort study from a 1200-bed university hospital in Bangkok reported on an increased incidence of CPE from 3.37 per 100,000 patient-days in 2011 to 32.49 per 100,000 patient-days between 2011 and 2016 [ 4 ]. (biomedcentral.com)
  • Patient medical records from January 2016 to December 2020 were examined. (medscimonit.com)
  • Se realizó la revisión retrospectiva del expediente clínico de pacientes ambulatorios y hospitalizados diagnosticados como infección urinaria que ingresaron en el Hospital Central del IPS entre marzo del 2015 y agosto del 2016.Se incluyeron 4014 aislamientos de enterobacterias de infecciones urinarias, 3224 (80,3%) fueron muestras ambulatorias y 790 (19,7%) de pacientes hospitalizados. (bvsalud.org)
Acute3
  • Patients typically present with chronic diarrhea, abdominal pain, and weight loss, but may present with more acute abdominal symptoms. (ispub.com)
  • Acute sinusitis in immunocompetent patients in the community is almost always viral (eg, rhinovirus, influenza, parainfluenza). (msdmanuals.com)
  • Blankenberg-Sprenkels SD, Fielder M, Feltkamp TW et al (1998) Antibodies to Klebsiella pneumoniae in Dutch patients with ankylosing spondylitis and acute anterior uveitis and to Proteus mirabilis in rheumatoid arthritis. (springer.com)
Ankylosing spondylitis5
  • Research conducted at King's College, London has implicated molecular mimicry between HLA-B27 and two Klebsiella surface molecules as the cause of ankylosing spondylitis. (wikipedia.org)
  • Their low toxicity and antibiotic bioactivity against K. pneumoniae indicate their potential for both preventing the onset of ankylosing spondylitis and minimising its symptoms once the disease is established. (springer.com)
  • Baines M, Ebringer A, Avakian H et al (1990) The use of enzyme immunoassay (EIA) and radiobinding assay to investigate the cross-reactivity of Klebsiella antigens and HLA-B27 in ankylosing spondylitis patients and healthy controls. (springer.com)
  • Braun J, Baraliakos X, Listing J et al (2005) Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and entanercept. (springer.com)
  • Chou CT, Uksila J, Toivanen P (1998) Enterobacterial antibodies in Chinese patients with rheumatoid arthritis and ankylosing spondylitis. (springer.com)
Virulence3
  • Klebsiella pneumoniae is an opportunistic pathogen of medical importance and the capsule and mucoid phenotype in this organism are considered as requisite virulence determinants. (scirp.org)
  • However, the virulence nature of the pathogenic K. pneumoniae in alcoholic patients has not been elucidated. (tmu.edu.tw)
  • The virulence of K. pneumoniae for mouse lethality was determined by the medium lethal dose (LD50). (tmu.edu.tw)
Molecular2
  • To gain a handle on the factors that are propelling the problem of AMR, molecular and patient-level investigations are necessary to better elucidate the time-varying and heterogeneous role of antibiotic selection pressure on emergence and selection of AMR. (europa.eu)
  • In summary, the overarching rationale of SATURN was to improve methodological standards and conduct research that will help to better understand the impact of antibiotic use on acquisition, selection and transmission of AMR in different environments, by combining analyses of molecular, individual patient-level and ecologic data. (europa.eu)
Extended-spectrum2
  • A urine culture collected at the time of readmission grew carbapenem-resistant K. pneumoniae and extended-spectrum β-lactamase-producing E. coli . (blogspot.com)
  • Extended spectrum betalactamase (ESBL) was found in 24.4% of E. coli and 50,3% of K. pneumoniae. (bvsalud.org)
Form of bronchopneumonia1
  • Most pulmonary diseases caused by K pneumoniae are in the form of bronchopneumonia or bronchitis. (medscape.com)
Pathogens2
  • The most common viral pathogens recovered from hospitalized patients admitted with CAP include human rhinovirus and influenza . (medscape.com)
  • found that, due to ongoing antibiotic treatment, the majority of their patients in intensive care units had dominance of their gut microbiome by potential pathogens. (cdc.gov)
Opportunistic pathogen1
  • It is also an opportunistic pathogen for patients with chronic pulmonary disease, enteric pathogenicity, nasal mucosa atrophy, and rhinoscleroma. (wikipedia.org)
Rectal1
  • Patients were divided according to whether they were "colonised" or "infected" with CPE and by the timing and frequency of their rectal swab collections, from which 45 swabs were randomly selected for analysis. (biomedcentral.com)
Nosocomial1
  • This within-patient diversity must be taken into account when characterizing transmission chains using WGS during nosocomial outbreaks. (pasteur.fr)
Diabetic1
  • Six patients were diabetic and 2 patients had liver cirrhosis. (tmu.edu.tw)
Pediatric1
  • A total of 23 sJIA patients who visited the Children's Hospital of Chongqing Medical University and the Pediatric Research Institute of Shenzhen Children ' s Hospital between July 2013 and September 2014 were selected for this study, including 13 males and 10 females, with a median age of 8.21 years old (4.56-10.08 years old). (scielo.br)
Genus1
Incidence1
  • The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. (ub.edu)
Pulmonary1
  • In addition, patients with atypical CAP may present with more subtle pulmonary findings, nonlobar infiltrates on radiography, and various extrapulmonary manifestations (eg, diarrhea, otalgia). (medscape.com)
Intensive1
  • Patients were rescreened if they stayed >7 days in the ED or were transferred to an intensive care unit. (bvsalud.org)
Mortality1
  • They are responsible for increased morbidity and mortality of patients admitted to hospitals. (paho.org)
Diagnosis2
  • Primary care physicians may be asked to evaluate patients with uveitis when an underlying systemic diagnosis is suspected but not apparent from eye examination or history. (aafp.org)
  • This review provides a framework for primary care physicians who are asked to examine patients with uveitis when an underlying systemic diagnosis is suspected after ophthalmologic evaluation. (aafp.org)
Genital2
  • Klebsiella chronic genital ulcerative disease presents as a firm papule or subcutaneous nodule that later ulcerates. (medscape.com)
  • METHODS--Sera from patients with proven granuloma inguinale, other sexually acquired genital ulcerations and blood donors from areas where granuloma inguinale is rarely encountered as well as from disease-endemic regions were tested. (bmj.com)