• Seventy-five patients with COPD (44 men) in a stable clinical state with mean age 70 years (SD 9 y), forced expiratory volume in one second 52% (SD 21%) predicted and baseline walking distance 359 meters (SD 104 m). (nih.gov)
  • Also, see eMedicineHealth's patient education articles Pulmonary Embolism , Bronchitis , Bacterial Pneumonia, ChronicObstructivePulmonaryDisease(COPD) , and Deep Vein Thrombosis (Blood Clot in the Leg, DVT) . (medscape.com)
  • Dissemination of good organisational practice and recruitment of more respiratory specialists offers the potential for improved outcomes for hospitalised COPD patients. (bmj.com)
  • 7 This study aimed to explore possible relationships between resources available for the care of COPD patients and organisation of care with the patient outcomes of death, LOS, and readmission. (bmj.com)
  • Pulmonary rehabilitation is a multidisciplinary approach to treating patients with chronic lung disease and is advocated in American, 1 British 2 and European 3 guidelines on the management of chronic obstructive pulmonary disease (COPD) as an important component of medical care. (bmj.com)
  • Since pulmonary rehabilitation has traditionally focused on patients with COPD, its effectiveness in other chronic lung diseases has received little attention, although it has been implemented with clinical success in patients with cystic fibrosis 4 and in those with restrictive pulmonary defects. (bmj.com)
  • 8 Theoretically, one would therefore expect pulmonary rehabilitation to be as effective in bronchiectasis as it is in COPD, but to date only one study has been performed which included only seven patients with the disease. (bmj.com)
  • The reduced exercise capacity and increased dyspnoea in patients with COPD is partly attributable to expiratory flow limitation resulting in dynamic hyperinflation and increased intrinsic positive end expiratory pressure, exacerbated by a reduction in inspiratory muscle force. (bmj.com)
  • Twenty seven patients with COPD‑AE were evaluated using a prospective longitudinal study design. (spandidos-publications.com)
  • Induced sputum, sera and nasal smears were sampled from patients experiencing COPD‑AE and those in a stable condition. (spandidos-publications.com)
  • Eighteen patients who experienced a COPD‑AE were also evaluated while in a stable condition. (spandidos-publications.com)
  • RSV serotype A was detected in 17/27 (63%) patients with COPD‑AE and 10/18 (55.6%) patients in a stable condition. (spandidos-publications.com)
  • Eight/ten patients who were positive for RSV serotype A while in a stable condition, were also positive during COPD‑AE. (spandidos-publications.com)
  • The results of the present study suggested that RSV infection may be prevalent in patients with COPD‑AE and in those in a stable condition. (spandidos-publications.com)
  • The aim of the present study was to investigate the prevalence of adenovirus and RSV A and B among patients with COPD-AE and those in a stable condition. (spandidos-publications.com)
  • The present study evaluated the association between viral infections, functional status and systemic inflammation in patients experiencing COPD-AEs and those in a stable condition. (spandidos-publications.com)
  • Nov. 20, 2023 /PRNewswire/ -- Olympus announced today study results showing the sustained clinical benefits of the Spiration™ Valve System (SVS) in treating patients suffering from the symptoms of severe emphysema, a form of chronic obstructive pulmonary disease (COPD). (whnt.com)
  • MARLBOROUGH, Mass.--( BUSINESS WIRE )-- Sunovion Pharmaceuticals Inc. (Sunovion) today announced that it has submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for SUN-101/eFlow ® , an investigational treatment for the long-term, maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD). (biospace.com)
  • GOLDEN-3 and GOLDEN-4 were Phase 3, 12-week, randomized, double-blind, placebo-controlled, parallel-group, multicenter efficacy and safety trials comparing SUN-101/eFlow ® with placebo in patients with moderate-to-very severe COPD. (biospace.com)
  • GOLDEN-5 was a Phase 3, 48-week, randomized, open-label, active-controlled, parallel-group, multicenter safety trial designed to evaluate the long term safety and tolerability of SUN-101/eFlow ® in patients with moderate-to-very severe COPD. (biospace.com)
  • This is an important milestone for us and the larger respiratory community, as we continue our mission of pioneering innovative treatments and therapies for COPD patients, their caregivers and healthcare providers. (biospace.com)
  • SUN-101 (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator delivered via the innovative, proprietary investigational eFlow ® nebulizer closed system for the treatment of patients with moderate-to-very severe chronic obstructive pulmonary disease (COPD). (biospace.com)
  • The aim of this paper is to assess the health economic consequences of substituting ipratropium with the new, once-daily bronchodilator tiotropium in patients with a diagnosis of chronic obstructive pulmonary disease (COPD). (ersjournals.com)
  • Patients had a diagnosis of COPD and a forced expiratory volume in one second (FEV 1 ) ≤65% predicted normal. (ersjournals.com)
  • In the coming decades, general practitioners, respiratory physicians and other healthcare providers will be confronted with an increasing share of their patient population being COPD patients 2 . (ersjournals.com)
  • Tiotropium is a new inhaled bronchodilator for patients with COPD with a sustained duration of action indicated for once daily dosing 4 . (ersjournals.com)
  • This cost-effectiveness analysis was performed alongside two randomised controlled, double-blind, double-dummy, parallel group trials comparing 18 µg tiotropium inhalation capsules administered once daily in the morning via the HandiHaler® device with ipratropium 2 puffs of 20 µg administered four times daily via the metered dose inhaler (MDI) in patients with airway obstruction due to COPD 5 . (ersjournals.com)
  • COPD is a progressive disease in which many patients develop an acute or sustained deterioration. (nature.com)
  • CID was defined as any of the following: ≥100 mL decrease from baseline in pre-dose forced expiratory volume in 1 second (FEV 1 ), ≥4 point increase in St George's Respiratory Questionnaire score or a moderate-to-severe COPD exacerbation occurring after the first dose of study medication. (nature.com)
  • Patients had moderate (62%) or severe (38%) COPD. (nature.com)
  • Glycopyrronium is a once-daily LAMA indicated for the maintenance treatment of patients with COPD. (nature.com)
  • 6 Phase III trials have shown that glycopyrronium produces rapid and sustained improvements in lung function, symptoms, health status, exercise endurance and exacerbation risk in patients with COPD. (nature.com)
  • COPD clinical trials primarily focus on bronchodilator response using minimal clinically important difference (MCID) to determine improvements in lung function and patient-reported outcomes. (nature.com)
  • The clinical trial Towards a Revolution in COPD Health (TORCH) study clearly showed in a three year follow up that patients with good adherence to their inhaler treatment presented a longer time before the first exacerbation, a lower susceptibility to exacerbation and lower all-cause mortality. (mdpi.com)
  • The Latin American Study of 24-h Symptoms in Chronic Obstructive Pulmonary Disease (LASSYC), a real-life study, evaluated the self-reported inhaler adherence in COPD patients in seven countries in a cross-sectional non-interventional study and found that approximately 50% of the patients had good adherence, 30% moderate adherence and 20% poor adherence. (mdpi.com)
  • Objective To evaluate the safety of benzodiazepines and opioids in patients with very severe chronic obstructive pulmonary disease (COPD). (bmj.com)
  • Patients 2249 patients starting long term oxygen therapy for COPD in Sweden between 2005 and 2009 in the national Swedevox Register. (bmj.com)
  • Conclusions Lower dose opioids are not associated with increased admissions or deaths in patients with COPD and might be safe for symptom reduction in severe respiratory disease. (bmj.com)
  • 5 Patients with severe COPD are more breathless than patients with advanced lung cancer and are breathless for longer periods of time. (bmj.com)
  • 9 Benzodiazepines are also used to treat anxiety and opioids to treat pain, conditions that are highly prevalent in patients with severe COPD. (bmj.com)
  • Risks might be higher in frail patients, especially if they have not previously been treated with either or both drugs, and in people with severe COPD and hypercapnia. (bmj.com)
  • Depression is common among patients with chronic obstructive pulmonary disease (COPD). (psychiatrist.com)
  • Patients with COPD may be more likely to have inadequate treatment with antidepressant medications. (psychiatrist.com)
  • We tested the hypothesis that depressed patients with COPD have lower odds of adequate duration of antidepressant therapy in the first 3 months of treatment compared to those without COPD. (psychiatrist.com)
  • The first few months of treatment appears to be a critical period for depressed patients with COPD who are started on antidepressants. (psychiatrist.com)
  • The causes for early antidepressant treatment inadequacy among patients with COPD require further investigation. (psychiatrist.com)
  • More intensive efforts may be necessary early in the course of treatment to assure high-quality pharmacologic therapy of depressed patients with COPD. (psychiatrist.com)
  • BACKGROUND: New parameters in the 6-minute walk test (6 MWT) are required for comprehensive analysis of exercise capacity in patients with chronic obstructive pulmonary disease (COPD). (who.int)
  • The aim of the present study was to apply a novel index, the desaturation distance ratio (DDR), to clinical research on COPD as an estimate of exercise capacity and to examine whether DDR is a potential parameter for manifold analysis of exercise capacity in patients with COPD. (who.int)
  • The Global Initiative for Chronic Obstructive Lung Disease (GOLD) was recently updated, to better meet the needs of patients, with a focus on COPD diagnostic and to identify treatable traits (symptoms and exacerbations) to help guide therapy. (chestnet.org)
  • This case-based two part webinar series is for the community-based pulmonologists and other health-providers seeing COPD patients to help recognize the importance of symptom-based burdens of COPD as a guide to pharmacological choices, that can also help optimize bronchodilation therapy and reduce exacerbations. (chestnet.org)
  • Effect of roflumilast on exacerbation rate in patients with COPD treated with fixed combinations of LABA and ICS. (astrazenecaclinicaltrials.com)
  • The objective of the REACT trial is to investigate the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate and pulmonary function in COPD patients who are concomitantly treated with a fixed combination of long-acting β2-agonists (LABA) and inhaled glucocorticosteroids (ICS). (astrazenecaclinicaltrials.com)
  • Patients to be included are required to have severe COPD associated with chronic bronchitis and a history of frequent exacerbations and must be concomitantly treated with a fixed combination of LABA and ICS. (astrazenecaclinicaltrials.com)
  • This study investigated the effect of roflumilast 500 μg tablets once daily versus placebo on exacerbation rate, pulmonary function, and major adverse cardiovascular events (MACE) in COPD patients who were concomitantly treated with a fixed combination of long-acting beta-agonists (LABA) and inhaled glucocorticosteroids. (astrazenecaclinicaltrials.com)
  • Background Chronic obstructive pulmonary disease (COPD) is one of the most common comorbidities in community acquired pneumonia (CAP) patients. (medscape.com)
  • We aimed to investigate the characteristics and mortality risk factors of COPD patients hospitalized with CAP. (medscape.com)
  • Logistic regression analysis was performed to screen mortality risk factors of COPD patients hospitalized with CAP. (medscape.com)
  • Results Of the total 520 CAP patients, 230 (44.2%) patients had been diagnosed comorbid with COPD (COPD-CAP). (medscape.com)
  • CAP patients comorbid with COPD patients had higher rate of need for ICU admission (18.3% vs 13.1%) and need for NIMV (26.1% vs 1.4%) than without COPD (nCOPD-CAP). (medscape.com)
  • 2.0 μg/mL and CURB-65 ≥ 3 were risk factors associated with in-hospital mortality ((odd ratio) OR = 5.678, OR = 4.268, OR = 20.764, respectively) in COPD-CAP patients. (medscape.com)
  • The risk factors associated with 60-day mortality in COPD-CAP patients were comorbid with coronary heart disease, aspiration, need for NIMV (non-invasive mechanical ventilation) and CURB-65 ≥ 3 (OR = 5.206, OR = 7.921, OR = 3.974, OR = 18.002, respectively). (medscape.com)
  • Conclusions COPD patients hospitalized with CAP had higher rate of need for NIMV, need for ICU admission and severity scores than those without COPD. (medscape.com)
  • 2.0 μg/mL, comorbid with coronary heart disease, need for NIMV and CURB-65 ≥ 3 were mortality risk factors in CAP patients comorbid with COPD. (medscape.com)
  • 2005). Asthma patients usually show improvements in post-bronchodilator spirometry testing, while patients with COPD exhibit little, if any, response to the medication. (cdc.gov)
  • Secondary endpoints were mean changes from baseline in post-bronchodilator forced expired volume in 1 s (FEV(1)) and CCQ scores. (nih.gov)
  • More than 90% of all patients showed good medication compliance at baseline and after 1 year. (cdc.gov)
  • The primary endpoint was the change from baseline in trough Forced Expiratory Volume in 1 second (FEV 1 ) at Week 12. (biospace.com)
  • Secondary endpoints included standardized change from baseline at Week 12 in FEV 1 area under the curve (AUC), change from baseline in trough forced vital capacity (FVC) at Week 12, change from baseline in health status measured by St. George's Respiratory Questionnaire and change in rescue medication use. (biospace.com)
  • Trough FEV 1 was improved above baseline by 120 mL after 1 yr for patients receiving tiotropium, whereas it was declined by 30 mL for patients receiving ipratropium. (ersjournals.com)
  • After antibiotics, the NS therapy group had a greater return toward baseline forced expiratory volume at 1 second and forced expiratory flow 25%-75% values than the BS group. (lww.com)
  • Patients must be pre-treated with LABA and ICS for at least 12 months before baseline Visit V0. (astrazenecaclinicaltrials.com)
  • In the last 3 months before baseline Visit V0 patients must be pre-treated with fixed combinations of LABA and ICS at a constant dose (maximum approved dosage strength of the combination). (astrazenecaclinicaltrials.com)
  • Single-blind baseline period (4 weeks) during which all patients received placebo. (astrazenecaclinicaltrials.com)
  • Physician judgment that the patient is likely to require surgical intervention of any kind for UC within 12 weeks of baseline. (who.int)
  • Phase II trials for asthma treatment showed increased lung function with increased forced expiratory volume for patients. (wikipedia.org)
  • The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. (ingentaconnect.com)
  • However, some patients with this condition have neutrophilic inflammation, whereas, conversely, some patients without asthma have eosinophilic inflammation. (cmaj.ca)
  • In genetically susceptible individuals, these interactions can lead the patient with asthma to symptoms of breathlessness, wheezing, cough, and chest tightness. (medscape.com)
  • Diary based assessments: morning and evening peak expiratory flow, visual analogue scale of severity of asthma, quality of life, and daily mood. (bmj.com)
  • Homoeopathic immunotherapy is not effective in the treatment of patients with asthma. (bmj.com)
  • In a previous study 28 patients with allergic asthma, primarily to house dust mite, were treated for 12 weeks with homoeopathic doses of allergen (homoeopathic immunotherapy) given as an ultramolecular preparation-that is, in dilutions in which there were probably no molecules of active ingredient present. (bmj.com)
  • Correcting hypokalemia may help to wean an intubated patient with asthma from mechanical ventilation. (medscape.com)
  • Larger studies are needed to confirm these findings and determine if other variables such as family history of depression or subjective assessment of asthma severity explain the high prevalence of depressive symptoms in these patients. (psychiatrist.com)
  • All patients in economic costs for families and nations on childhood asthma. (who.int)
  • 4 ings highlight the critical need for spirometry services to identify lung abnormalities in patients with chronic res- piratory symptoms. (who.int)
  • All patients were instructed in the correct use of their inhaled medication and the use of a peak flow meter. (cdc.gov)
  • Before the intervention and after 1 year, patients were asked to keep a diary for 2 weeks reporting on symptoms, medication use, and peak expiratory flow (PEF) rates. (cdc.gov)
  • The peak frequency of snoring was significantly lower in OSA patients, with all but one OSA patient and only one simple snorer showing a peak frequency below 150 Hz. (researchgate.net)
  • There was a different pattern of change over the trial for three of the diary assessments: morning peak expiratory flow (P=0.025), visual analogue scale (P=0.017), and mood (P=0.035). (bmj.com)
  • This study aimed to explore associations between resources and organisation of care and patient outcomes. (bmj.com)
  • Substituting tiotropium for ipratropium in chronic obstructive pulmonary disease patients offers improved health outcomes and is associated with increased costs of 180 per patient per year. (ersjournals.com)
  • Likewise, whether specific patient and disease characteristics predict perioperative outcomes for these patients is not well known. (researchsquare.com)
  • The American College of Chest Physicians (CHEST) is the global leader in advancing best patient outcomes through innovative chest medicine education, clinical research, and team-based care. (chestnet.org)
  • The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. (spandidos-publications.com)
  • Only intervention group patients showed improvements in both self-treatment and self-management behavior when presented with a hypothetical scenario of a slow-onset exacerbation. (cdc.gov)
  • Incremental cost-effectiveness ratios were 667 per exacerbation avoided and 1084 per patient with a relevant improvement on the SGRQ. (ersjournals.com)
  • This document compiles updated information available on the definition, risk factors, evaluation methods, treatment and special situations in cancer patients with febrile neutropenia. (ijpsonline.com)
  • Static lung volumes measured by plethysmographic or helium dilution methods. (cdc.gov)
  • METHODS: We included 161 patients with infrainguinal critical limb ischemia (CLI). (scielo.br)
  • Methods 822 newly diagnosed patients with OSA referred for PAP treatment were recruited. (researchgate.net)
  • ABSTRACTBackground: This study aimed to compare paravertebral block and continuous intercostal nerve block after thoracotomy.Methods: Forty-six adult patients undergoing elective posterolateral thoracotomy were randomised to receive either acontinuous intercostal nerve blockade or a paravertebral block. (bvsalud.org)
  • These data support the use of 6MWD as a patient-important outcome in research and clinical practice. (nih.gov)
  • The data emanating from the EMPROVE trial underscore the clinical advantages that the Spiration Valve holds for patients and illustrate that this BLVR treatment significantly enhances the daily lives of patients," said Dr. Stephanie Nsiah-Dosu , Respiratory Global Medical Manager for Medical and Scientific Affairs at Olympus Corporation. (whnt.com)
  • Several risk factors can lead to the development of FN in cancer patients, the most representative were listed in the clinical practice guideline developed by the American Society of Clinical Oncology along with the Infectious Diseases Society of America (ASCO/IDSA). (ijpsonline.com)
  • Patients are at the heart of everything we do at Sunovion," said Antony Loebel, M.D., Executive Vice President and Chief Medical Officer at Sunovion, Head of Global Clinical Development for Sumitomo Dainippon Pharma Group. (biospace.com)
  • Our primary aim was to evaluate morbidity and mortality in a contemporary cohort of adult patients with PH undergoing noncardiac surgery and to explore the association between clinical and diagnostic parameters and morbidity and mortality. (researchsquare.com)
  • We evaluated the clinical and arteriographic (number and presence of opacification of leg arteries) of the two groups of patients. (scielo.br)
  • Aim To study the effect of positive airway pressure (PAP) treatment on nocturnal gastroesophageal reflux (nGER) and respiratory symptoms among clinical OSA patients. (researchgate.net)
  • however, many patients present with metastatic disease with or without any clinical symptoms. (msdmanuals.com)
  • Clinical and demographic data in patients diagnosed with CAP were collected between January 2015 and June 2016. (medscape.com)
  • showed that zinc supplements had the 345 patients assessed for eligibility, tract system and is more common in no effect on the clinical manifestations 30 did not meet the inclusion criteria, children than adults ( 1 ). (who.int)
  • The risk model was more accurate at predicting operative mortality in adult patients undergoing congenital cardiac surgery (C statistic, 0.815) than the existing Society of Thoracic Surgeons adult risk model without congenital variables (C statistic, 0.79). (ctsnet.org)
  • This will support an online risk calculator for adult patients undergoing congenital cardiac surgery. (ctsnet.org)
  • To understand the impact of COVID-19 on ADL performance of adult patients and to describe the common scales used to assess performance of ADL on patients post-COVID-19. (peerj.com)
  • Consecutive adult patients aged 18 and above with chronic respiratory symptoms (lasting more than 8 weeks) and no evidence of active tuberculosis were recruited. (who.int)
  • In conclusion, this study demonstrates significant differences in the sound power spectrum of snoring sound between subjects with simple snoring and obstructive sleep apnoea patients. (researchgate.net)
  • The study on twelve male patients with obstructive pulmonary disease showed transient improvement in general lung function. (fleetfeet.com)
  • Since patients with severe AATD may have a very different prognosis and AT requires intravenous infusions for life, the decision to initiate AT may be challenging. (dovepress.com)
  • The EMPROVE study is the first randomized controlled trial to present a rigorous comparison of bronchoscopic lung volume reduction (BLVR) using endobronchial valve (EBVs) with standard-of-care controls for up to 24 months in severe emphysema patients. (whnt.com)
  • Patients with severe heterogeneous emphysema were randomly assigned treatment with the Spiration™ Valve System or to the control group. (whnt.com)
  • [ 3 ] In Western countries, the financial burden on patients ranges from $300 to $1,300 per patient year, increasing with more severe disease. (medscape.com)
  • more than half of all expenditures are attributed to the 10-20% of patients with the most severe disease. (medscape.com)
  • Two patients in the CCB group received a rescue interscalene block due to severe postoperative pain. (unboundmedicine.com)
  • Ramelteon Tablets are not recommended in patients with severe hepatic impairment. (nih.gov)
  • For the intervention group only, during the last 2 weeks of the study, there was an increase in the proportion of patients who adjusted their medication in response to an increase in symptoms or a decline in PEF. (cdc.gov)
  • The effect of each treatment on the forced expiratory volume in 1 s (FEV 1 ), provocative concentration of methacholine causing a 20% decline in FEV 1 (PC 20 ), early and late asthmatic responses, and allergen-induced inflammation were measured.RESULTS: Seventeen subjects completed the study. (hindawi.com)
  • There is an acute need for more effective treatment options to reduce the burden of this disease for patients, caregivers and society. (ersjournals.com)
  • All included studies found a reduction of ADL beyond the test or scale used, revealing a vital worsening of functional ability in ADL performance and consequently loss of independence in COVID-19 patients after the acute phase of infection. (peerj.com)
  • In these trials 38% and 36% of patients respectively, met the primary efficacy goal of the trial, compared to 8% and 10% under placebo. (wikipedia.org)
  • Patients in the 100 and 150 mg combination dose groups showed statistically significant mean relative improvements in lung function, versus placebo, of 9.0 percent (p=0.01) and 7.5 percent (p=0.02), respectively, at Day 28. (vrtx.com)
  • In contrast, patients who received placebo showed a 0.03 percent mean relative change in lung function at Day 28 (within-group). (vrtx.com)
  • One group of patients was randomized to receive either VX-661 (10, 30, 100 and 150 mg dosed once daily), or placebo, alone for 28 days. (vrtx.com)
  • A separate group of patients was randomized to receive the combination of VX-661 (10, 30, 100 and 150 mg dosed once daily) and ivacaftor (150 mg dosed twice daily), or placebo, for 28 days. (vrtx.com)
  • In the current study, Dr. Taylor-Cousar and colleagues from 91 study sites in the United States, Canada and Europe, evaluated 475 patients with two copies of 508del who took the ivacaftor-tezacaftor combination or a placebo for 24 weeks. (nationaljewish.org)
  • Patients taking the ivacaftor-tezacaftor combination also experienced fewer respiratory adverse events, including respiratory infections, cough, headache and fatigue, than did those taking placebo. (nationaljewish.org)
  • Dans un essai clinique randomisé d'une durée de 8 semaines, en double aveugle et contrôlé contre placebo, 284 enfants sous corticostéroïdes inhalés ont été répartis entre un groupe recevant une supplémentation en zinc (50 mg/jour) (n = 144) et un groupe sous placebo (n = 140). (who.int)
  • Denver - Researchers at National Jewish Health and around the world report in the New England Journal of Medicine that a novel combination of medications improves lung function and reduces disease exacerbations in cystic fibrosis patients with the most common form of the disease. (nationaljewish.org)
  • Patients were randomised to tiotropium (18 µg once daily) or ipratropium (2 puffs of 20 µg administered four times daily) in a ratio of 2:1. (ersjournals.com)
  • The European Society for Medical Oncology (ESMO, 2016) reported an incidence of approximately 8 cases of FN per 1000 patients who received chemotherapy[ 1 ]. (ijpsonline.com)
  • Patients with PH, 18 years and older, were identified from the Mayo Clinic Pulmonary Hypertension database with rationale that patients in registry have complete and detailed assessments of their PH. (researchsquare.com)
  • Patients treated with the Spiration Valve System experienced a significant improvement in lung function, respiratory symptoms and quality-of-life scores at 24 months, according to published study results. (whnt.com)
  • The findings revealed worsening of physical function and ADL performance in all patients post COVID-19 infection. (peerj.com)
  • We know that lung function correlates with survival, so that is great news for patients with cystic fibrosis and the doctors who care for them. (nationaljewish.org)
  • The patient has maintained long-term remission since the haplo-PBSCT, and his kidney function was restored by the kidney transplantation from his father. (bvsalud.org)
  • This study aimed to characterize the common chronic respiratory diseases, along with their lung function and possible determinants in symptomatic patients attending clinics at Bishoftu General Hospital, Ethiopia. (who.int)
  • Conclusion: This study demonstrated a high burden of abnormal lung function in patients attending clinics due to chronic respiratory symptoms. (who.int)
  • These findings suggest that in the patient sample studied, depressive symptoms appear to be common. (psychiatrist.com)
  • Some patients have had additional symptoms such as dyspnea, throat closing, or nausea and vomiting that suggest anaphylaxis. (nih.gov)
  • The NCCN advises that patients are not eligible for lung cancer screening if they have symptoms of lung cancer, a past history of lung cancer, or functional status and/or comorbidity that would prohibit curative intent treatment. (medscape.com)
  • In a number of studies, β -carotene supplementation in CF patients led to positive effects such as increase of total antioxidant capacity and decrease of pulmonary exacerbations [ 15 - 17 ]. (hindawi.com)
  • Twenty patients, 6-20 years of age, experienced 30 exacerbations. (lww.com)
  • The role of pulmonary rehabilitation (PR) and inspiratory muscle training (IMT) has not been investigated in this group of patients. (bmj.com)
  • This results in delivery of 375 mcg aclidinium bromide from the mouthpiece, based on in vitro testing at an average flow rate of 63 L/min with constant volume of 2 L. The amount of drug delivered to the lungs will vary depending on patient factors such as inspiratory flow rate and inspiratory time. (rxlist.com)
  • Despite recent therapeutic advances, febrile neutropenia is still a major cause of morbidity and mortality among cancer patients in Latin America and worldwide. (ijpsonline.com)
  • Febrile Neutropenia (FN) is a common complication of chemotherapy and a main cause of morbidity and mortality in cancer patients[ 1 ]. (ijpsonline.com)
  • We aimed to determine predictors of perioperative morbidity and mortality after noncardiac surgery for patients with precapillary PH. (researchsquare.com)
  • Patients with pulmonary hypertension (PH) are at increased risk for perioperative morbidity and mortality [1-3], and PH is an independent risk factor for complications after noncardiac surgery [4]. (researchsquare.com)
  • β -Carotene is a major source of retinol and therefore is of particular significance in CF. The aim of this study was to investigate the effect of daily intake of red palm oil (RPO) containing high amounts of β -carotene on the antioxidant levels in CF patients. (hindawi.com)
  • This study points to the significant and positive long-term impact SVS treatment can have on the day-to-day functions of emphysema patients," said Dr. John de Csepel , Chief Medical Officer at Olympus Corporation. (whnt.com)
  • Objective The study objective was to assess in a randomized controlled study NCT00566839 the comparative results of awake nonresectional or nonawake resectional lung volume reduction surgery. (pulsus.com)
  • A multicenter study in Argentina reported 515 episodes of FN in 346 patients, of which 77 % were secondary to chemotherapy. (ijpsonline.com)
  • The study group included 56.5 % of patients with hematological malignancies and 20.2 % with solid neoplasms [ 7 ]. (ijpsonline.com)
  • The study enrolled 1,087 patients at 111 investigational sites in the United States and Europe. (biospace.com)
  • Patients with a history of autoimmune disease resulting in end-organ injury are not eligible unless attributable to primary disease which is target of this study. (moffitt.org)
  • Patient is currently participating in another investigation treatment study or has participated in a study of an investigational agent within 4 weeks prior to leukapheresis. (moffitt.org)
  • All included patients gave consent to be included in the study. (researchsquare.com)
  • This study included patients with groups 1, 3, or 4 PH. (researchsquare.com)
  • The study also evaluated a separate group of patients who received VX-661 (10, 30, 100 and 150 mg) dosed without ivacaftor for 28 days. (vrtx.com)
  • There has been one study that showed minimal to no effect of using montelukast in the emergency department setting for patients with status asthmaticus. (medscape.com)
  • The study was targeted to enroll approximately 1934 patients. (astrazenecaclinicaltrials.com)
  • Patients who underwent single lung transplantation in our center (Marseille, France) between January 2009 and January 2022 were retrospectively included. (frontiersin.org)
  • All patients (except the control group) underwent an 8 week training programme of either PR or PR plus targeted IMT. (bmj.com)
  • Previous audits have shown wide variability in the length of stay and mortality between units not explained by patient factors. (bmj.com)
  • Hospital admissions carry a high mortality and patients may have extended lengths of stay. (bmj.com)
  • In forty-eight consecutive patients undergoing explants of transcatheter aortic valve replacement (TAVR) at a single center between 2011 and 2021, at a median of 2.3 years after TAVR, the most common indications for surgery were nonstructural valve dysfunction (patient-prosthesis mismatch or paravalvular leak) in 35 percent, structural valve deterioration in 29 percent, and mitral valve disease in 29 percent. (ctsnet.org)
  • Seventy patients, aged 20 to 70 years with ASA Physical Status classifications I to III and scheduled for elective arthroscopic rotator cuff repair were recruited. (unboundmedicine.com)
  • Most of the guidelines recommend offering annual screening with low-dose computed tomography (LDCT) scanning to patients aged 50 to 80 years who have at least a 20 pack-year smoking history and either continue to smoke or have quit within the past 15 years. (medscape.com)
  • [ 1 ] The USPSTF recommends discontinuing screening once 15 years have gone by since the patient stopped smoking, or if the patient develops a health problem that "substantially limits life expectancy or the ability or willingness to have curative lung surgery. (medscape.com)
  • However, the patient needed dialysis for end-stage renal disease due to thrombotic microangiopathy 3 years and 2 months after haplo-PBSCT. (bvsalud.org)
  • Recent reports, however, are more favorable, with 71% of affected patients alive at 10 years. (medscape.com)
  • Augmentation therapy (AT) is the only specific treatment licensed for patients with alpha-1 antitrypsin deficiency (AATD) associated lung disease. (dovepress.com)
  • Patients were randomized into a self-treatment group or an active control group. (cdc.gov)
  • Physicians and researchers work close together to provide innovative treatment options for patients. (moffitt.org)
  • Patient requires treatment with warfarin. (moffitt.org)
  • 98% of patients with end stage respiratory disease experience breathlessness, which persists at rest or on minimal exertion, despite optimal treatment of the underlying disease (chronic refractory breathlessness). (bmj.com)
  • Patients who develop angioedema after treatment with Ramelteon Tablets should not be rechallenged with the drug. (nih.gov)
  • Since sleep disturbances may be the presenting manifestation of a physical and/or psychiatric disorder, symptomatic treatment of insomnia should be initiated only after a careful evaluation of the patient. (nih.gov)
  • The guideline set of more than 275 recommendations includes an executive summary of current recommendations for diagnosis and treatment, along with additional recommendations for screening, chemoprevention and treatment of tobacco use in patients with lung cancer. (medscape.com)
  • Pulmonary complications occur much more often than cardiac complications in patients undergoing elective surgery to the thorax and upper abdomen. (medscape.com)
  • Patients were excluded if PH was attributable to left-sided heart disease or they had undergone cardiac or transplant operations. (researchsquare.com)
  • 95% in pregnant patients or those with cardiac disease). (medscape.com)
  • Sixty-three patients were randomly assigned by computer to receive unilateral video-assisted thoracic surgery lung volume reduction surgery by a nonresectional technique performed through epidural anesthesia in 32 awake patients awake group or the standard resectional technique performed through general anesthesia in 31 patients control group. (pulsus.com)
  • Conclusions: Patients with PH undergoing noncardiac surgery with general anesthesia have a high frequency of perioperative complications. (researchsquare.com)
  • These patients were cross-referenced with those in the anesthesia electronic database to identify all patients who had undergone noncardiac, nontransplant operations with general anesthesia between February 10, 2010, and December 8, 2017. (researchsquare.com)
  • In most cases of pulmonary agenesis, surgical resection is performed to remove the malformed lobe or the entire defected lung of the patient depending on the severity of the respiratory impairment. (wikipedia.org)
  • Patients who have contraindication to the lymphodepletion chemotherapy regimen. (moffitt.org)
  • Gilteritinib was discontinued, and the patient achieved CR with salvage chemotherapy. (bvsalud.org)
  • In combination with neuromuscular blockers, anesthetic agents cause diaphragm and chest wall relaxation, which results in a marked reduction in the functional reserve capacity and, thereby, thoracic volume. (medscape.com)
  • The results from the EMPROVE trial demonstrate the positive impact the Spiration Valve can have on emphysema patients," said Dr. Gerard Criner , Chair and Professor of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine at Temple University and director of the Temple Lung Center, who is lead investigator of the EMPROVE trial. (whnt.com)
  • This decrease in lung volume promotes atelectasis in the dependent lung regions and persists for more than 24 hours in 50% of patients. (medscape.com)
  • Thirty two patients with idiopathic bronchiectasis were randomly allocated to one of three groups: PR plus sham IMT (PR-SHAM), PR plus targeted IMT (PR-IMT), or control. (bmj.com)
  • Moreover, the following report allows to classify patients according to their risk level and to provide the best pharmacological strategy with their respective doses and routes of administration. (ijpsonline.com)
  • Rare cases of angioedema involving the tongue, glottis or larynx have been reported in patients after taking the first or subsequent doses of Ramelteon Tablets. (nih.gov)
  • Given its availability and ease of use, several studies have focused on the assessment of the diaphragm thanks to CT, particularly in patients undergoing chronic respiratory diseases. (frontiersin.org)
  • These diseases are typically characterized by a reduction in expiratory air flow rates. (cdc.gov)
  • The goal of perioperative pulmonary management is to identify patients at high risk of significant postoperative pulmonary complications, so that appropriate interventions can be provided to minimize that risk. (medscape.com)
  • 4 , 5 however, hospital-based health care providers infrequently engage patients and families in such conversations. (cmaj.ca)
  • Patients and families come to National Jewish Health from around the world to receive cutting-edge, comprehensive, coordinated care. (nationaljewish.org)
  • A risk model was developed using forty-seven congenital variables in 192,196 patients operated on between 2011 and 2019. (ctsnet.org)
  • In most cases, even in high-risk patients, the procedure can be performed safely as planned, but occasionally postponement, modification, or cancellation are warranted. (medscape.com)
  • Not all of these risk factors are modifiable, although strategies exist to reduce the risk of postoperative pulmonary complications even among high-risk patients. (medscape.com)
  • This classification allows patients to be categorized into risk groups for their management[ 3 ]. (ijpsonline.com)
  • The FDA recommends that healthcare providers be aware of the risk of SVD with Trifecta valves, discuss risk with patients, and monitor patients who have undergone implantation with Trifecta valves.Because of the potential risk of early structural valve deterioration, the FDA has sent notice about Abbott's decision to stop selling and distributing Trifecta aortic surgical heart valves in the United States. (ctsnet.org)
  • The FDA recommends that healthcare providers be aware of the risk of SVD with Trifecta valves, discuss risk with patients, and monitor patients who have undergone implantation with Trifecta valves. (ctsnet.org)
  • Sweating it out via regular exercise reduces the risk of high blood pressure by making the heart stronger, pumping blood with less effort and reducing the force on arteries. (fleetfeet.com)
  • The NCCN guidelines recommend starting screening at age 50 in patients with at least a 20 pack-year smoking history who are at high risk. (medscape.com)
  • Chronic pulmonary infection of CF patients results in a chronic activation of immune cells, especially neutrophilic granulocytes, leading to a permanent production of free radicals and lipid peroxidation (LPO) products, thus triggering inflammation [ 3 - 6 ]. (hindawi.com)
  • Results: Of 196 patients with PH undergoing noncardiac operations, 53 (27%) experienced 1 or more complications, including 5 deaths (3%) within 30 days. (researchsquare.com)
  • Results 1681 (76%) patients were admitted to hospital, and 1129 (50%) died under observation. (bmj.com)
  • None of the guidelines recommend using chest radiography or sputum cytology to screen asymptomatic patients for lung cancer. (medscape.com)
  • Postoperative pulmonary complications are also more common in patients with preexisting lung disease, medical comorbidities, poor nutritional status, overall poor health, and in those who smoke. (medscape.com)
  • For excellent patient education resources, visit eMedicineHealth's Lung Disease and Respiratory Health Center . (medscape.com)
  • The nutritional status of CF patients is recognized as strong predictor of the severity of CF lung disease. (hindawi.com)
  • Patients were encouraged to ask questions and discuss personal matters related to their disease. (cdc.gov)
  • Lorig KR, Sobel DS, Ritter PL, Laurent D, Hobbs M. Effect of a self-management program on patients with chronic disease. (cdc.gov)
  • Self-management programs also provide patients with the knowledge, skills, and confidence to manage disease-related problems. (cdc.gov)
  • Patients with a history of immunodeficiency (except for acquired hypogammaglobulinemia), patients with active autoimmune disease requiring systemic immunosuppressive therapy (i.e. (moffitt.org)
  • Despite it being widely studied all over the world, little is known about the impact of the disease on functional ability related to performing activities of daily living (ADL) in patients post COVID-19 infection. (peerj.com)
  • Although primarily a disease of women of childbearing age, lymphangioleiomyomatosis (LAM) has also been reported in postmenopausal patients. (medscape.com)
  • 8] The statistics may improve further as patients are diagnosed earlier (lead-time bias) or with more benign disease. (medscape.com)
  • Inform patients about their disease because education is an important issue in this condition. (medscape.com)
  • Most cases were recommended AT according to guidelines, but a significant number of patients with genotype Pi*SZ and almost 10% Pi*MZ were recommended to initiate AT despite the lack of evidence of efficacy in these genotypes. (dovepress.com)
  • In primarily depressed patients, worsening of depression (including suicidal ideation and completed suicides) has been reported in association with the use of hypnotics. (nih.gov)
  • Recent studies have suggested that the acoustic characteristics of snoring sound may differ between simple snorers and OSA patients. (researchgate.net)
  • We have studied a small number of patients with simple snoring and OSA, analysing the acoustic characteristics of the snoring sound. (researchgate.net)