Patients erythropoiesis. Medical search. Frequent questions

In this work, we assessed the potential of oxidative stress parameters to predict the response to erythropoiesis-stimulating agents (ESAs) in lower-risk MDS patients. (uc.pt)
Background: Functional iron deficiency has been found to be a common cause of poor response to erythropoiesis stimulating agents in anaemic patients with chronic kidney disease (CKD). (bvsalud.org)

β-Thalassemia (BT) is an inherited genetic disorder that is characterized by ineffective erythropoiesis (IE), leading to anemia and abnormal iron metabolism. (thalassaemia.org.cy)
Congenital dyserythropoietic anemia type IV is an autosomal dominant inherited red blood cell disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. (wikipedia.org)
Anemia of cancer is characterized by ineffective erythropoiesis, which is due to a number of factors. (medscape.com)

If left untreated, three main factors are responsible for the clinical sequelae of NTDT: ineffective erythropoiesis, chronic hemolytic anemia, and iron overload. (hindawi.com)
The first one is chronic hypoxia resulting from chronic anemia and ineffective erythropoiesis leading to mitochondrial damage and the second is iron overload also due to chronic anemia and tissue hypoxia leading to increase intestinal iron absorption in thalassemic patients. (hindawi.com)
Thalassemia is an entity involving a collection of inherited diseases caused by defective or absent hemoglobin chain synthesis leading to anemia due to ineffective erythropoiesis. (hindawi.com)

Does hepcidin affect erythropoiesis in hemodialysis patients? (uth.gr)
In a study, the mean hemoglobin level increased significantly in hemodialysis patients with functional iron deficiency. (renalandurologynews.com)
Changes in Metabolomic Profiles Induced by Switching from an Erythropoiesis-Stimulating Agent to a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor in Hemodialysis Patients: A Pilot Study. (bvsalud.org)
In this prospective, single-center study, we comprehensively investigated changes in plasma metabolomic profiles following the switch from an erythropoiesis -stimulating agent (ESA) to an HIF-PHI, daprodustat, in 10 maintenance hemodialysis patients . (bvsalud.org)
Our results provide detailed insights into the systemic biological effects of HIF-PHIs in hemodialysis patients and are expected to contribute to an evaluation of the potential side effects that may result from long-term use of this class of drugs . (bvsalud.org)

The weekly erythropoietin dose, last-month intravenous iron dose and the patients' demographics were recorded. (uth.gr)
A randomized, placebo-controlled trial of pentoxifylline on erythropoiesis-stimulating agent hyporesponsiveness in anemic patients with CKD: the Handling Erythropoietin Resistance With Oxpentifylline (HERO) trial. (ox.ac.uk)
SETTING & PARTICIPANTS: 53 adult patients with CKD stage 4 or 5 (including dialysis) and ESA-hyporesponsive anemia (hemoglobin≤120g/L and ESA resistance index [calculated as weight-adjusted weekly ESA dose in IU/kg/wk divided by hemoglobin concentration in g/L]≥1.0IU/kg/wk/g/L for erythropoietin-treated patients and ≥0.005μg/kg/wk/g/L for darbepoetin-treated patients). (ox.ac.uk)
In several studies reported between 1990 and 2001, recombinant human erythropoietin (r-HuEPO, epoetin alfa) increased haemoglobin (Hb) levels and subsequently ameliorated anaemia in cancer patients. (nature.com)
Anemia in pregnancy and the puerperium should be treated according to a staged regimen, administering either iron alone or in combination with an off-label use of human recombinant erythropoietin in selected patients. (karger.com)
BACKGROUND: Among patients with chronic kidney disease (CKD), the use of recombinant human erythropoietin and its derivatives for the treatment of anemia has been linked to a possibly increased risk of stroke, myocardial infarction, and other adverse events. (nih.gov)
Red cell production in vertebrates is controlled by a glycoprotein hormone known as erythropoietin (Ep), which is produced by the kidney in response to hypoxia and acts on the marrow to selectively stimulate erythropoiesis. (nih.gov)
Red blood cell (RBC) production (erythropoiesis) takes place in the bone marrow under the control of the hormone erythropoietin (EPO). (msdmanuals.com)
however, in the setting of stress erythropoiesis, as in a high erythropoietin level (eg, in persons with severe anemia), reticulocytes are prematurely released from bone marrow to the blood circulation, increasing the number of days that reticulocytes stay in the blood circulation (maturation time of reticulocytes in days) and resulting in a spuriously high reticulocyte count. (medscape.com)

In this scenario, supportive treatment to raise hemoglobin levels and diminish symptoms from anemia, including erythropoiesis-stimulating agents (ESAs), may become necessary. (springermedizin.at)

These functionally high prohepcidin levels may be associated with the factors that inhibit erythropoiesis in HD patients. (uth.gr)
[ 5 ] It is also associated with high levels of PTH, which has been shown to inhibit erythropoiesis, induce hemolysis and cause bone marrow fibrosis in CKD states. (medscape.com)

We performed a prospective observational study of patients with uncomplicated malaria to investigate whether posttreatment hemolysis also occurs after oral artemisinin-based combination therapy. (cdc.gov)
Eight of 20 patients with uncomplicated malaria who were given oral artemisinin-based combination therapy met the definition of posttreatment hemolysis (low haptoglobin level and increased lactate dehydrogenase level on day 14). (cdc.gov)
Five patients had hemolysis persisting for 1 month. (cdc.gov)
Episodes of delayed hemolysis 2-6 weeks after treatment for severe malaria with intravenous artesunate have been observed in non-malaria-immune patients in Europe ( 2 ). (cdc.gov)
This phenomenon, recently referred to as postartemisinin-delayed hemolysis (PADH) ( 3 , 4 ), has been confirmed in other nonimmune patients ( 4 , 5 ) and in children in Africa ( 6 ). (cdc.gov)
Hemolysis is usually self-limiting, but patients need to be actively followed up because transfusion of erythrocytes and rehospitalization might be necessary ( 2 , 5 ). (cdc.gov)
Only 2 single cases and 2 patients in a recent analysis of surveillance data in the United States have been reported with signs of delayed hemolysis after oral ACT treatment ( 11 - 13 ). (cdc.gov)
We hypothesize that delayed hemolysis occurs not only after intravenous treatment for severe malaria but also in a substantial number of patients given oral ACTs for uncomplicated malaria. (cdc.gov)

The Phase 3 portion of the IMerge Phase 2/3 study is a double-blind, 2:1 randomized, placebo-controlled clinical trial to evaluate imetelstat in patients with IPSS Low or Intermediate-1 risk (lower risk) transfusion dependent MDS who were relapsed after, refractory to, or ineligible for, erythropoiesis stimulating agent (ESA) treatment, had not received prior treatment with either a HMA or lenalidomide and were non-del(5q). (businesswire.com)

How to Facilitate Decision-Making for Hematopoietic Stem Cell Transplantation in Patients With Hemoglobinopathies. (thalassaemia.org.cy)
The possible underlying mechanisms are proposed to come mainly from bone marrow, including stimulated erythropoiesis with hyperplasia of the hematopoietic bone marrow, improvement of the hematopoietic microenvironment induced by exercise training, and hormone- and cytokine-accelerated erythropoiesis. (karger.com)
Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
Hematopoietic stem cell transplantation is the only potentially curative therapy, but it is only an option for select patients. (cancernetwork.com)

Erythropoiesis-stimulating agents (ESAs) reduce red blood cell (RBC) transfusions in approximately 40% of patients with myelodysplastic syndrome (MDS) in clinical trials. (aamds.org)
Guillermo Garcia-Manero, MD, from MD Anderson Cancer Center, explores imetelstat trial results of patients with transfusion-dependent lower-risk myelodysplastic syndromes who experience failure to or are ineligible for treatment with erythropoiesis-stimulating agents. (theoncologynurse.com)
Is it safe to use erythropoiesis-stimulating agents to treat anemia in chronic kidney disease patients with active malignancies? (johnshopkins.edu)
Tonelli M, Hemmelgarn B, Reiman T, Manns B, Reaume MN, Lloyd A, Wiebe N, Klarenbach S: Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis. (karger.com)
Epogen, Procrit and Aranesp are known as erythropoiesis-stimulating agents (ESAs). (yourlawyer.com)
The authors wrote that the findings "show that erythropoiesis-stimulating agents increase mortality in all patients with cancer, and a similar increase might exist in patients on chemotherapy. (yourlawyer.com)
Historically, patients with this debilitating disease have had limited treatment options, and disease-modifying agents were not available. (cancernetwork.com)
Patients prescribed the lipid-lowering agents were less likely to exhibit hyporesponsiveness to the medications. (renalandurologynews.com)
Evans M, Carrero JJ, Bellocco R, Barany P, Qureshi AR, Seeberger A, Jacobson SH, Hylander-Rössner B, Rotnitzky A, Sjölander A. Initiation of erythropoiesis-stimulating agents and outcomes: a nationwide observational cohort study in anaemic chronic kidney disease patients. (janusinfo.se)
In controlled trials, patients experienced greater risks for death, serious adverse cardiovascular reactions, and stroke when administered erythropoiesis-stimulating agents (ESAs) to target a hemoglobin level of greater than 11 g/dL. (takeda.com)

Anemic patients affected by BT suffer from iron overload, even in the absence of chronic blood transfusion, suggesting the presence of ≥1 erythroid factor with the ability to modulate iron metabolism and dietary iron absorption. (thalassaemia.org.cy)
Courneya KS, Jones LW, Peddle CJ, Sellar CM, Reiman T, Joy AA, Chua N, Tkachuk L, Mackey JR: Effects of aerobic exercise training in anemic cancer patients receiving darbepoetin alfa: a randomized controlled trial. (karger.com)
The elderly, along with patients with renal disease, cancer, heart failure, or diabetes mellitus are more likely to be anemic. (lww.com)
The odds of major adverse cardiac events were 46% to 76% higher in anemic vs. non-anemic patients. (renalandurologynews.com)

Dolan LB, Gelmon K, Courneya KS, Mackey JR, Segal RJ, Lane K, Reid RD, McKenzie DC: Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy. (karger.com)
Among other things, the agency mandated that the labeling be modified to say that the drugs shouldn't be used in cancer patients receiving chemotherapy when a cure of their cancer is anticipated. (yourlawyer.com)

We studied the association of timing of ESA initiation, agent (epoetin alfa, darbepoetin) and number of weeks of ESA use with response in MDS patients in routine practice. (aamds.org)
Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer patients receiving non-platinum-based chemotherapy. (nature.com)
These findings provide evidence that increasing haemoglobin levels by epoetin alfa administration can significantly improve cancer patients' quality of life. (nature.com)
In these studies, the efficacy of roxadustat was demonstrated across the spectrum of CKD compared with placebo in nondialysis-dependent patients and compared with epoetin alfa (Epogen Procrit) in dialysis-dependent patients. (medscape.com)
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with methoxy polyethylene glycol-epoetin beta injection and each time you refill your prescription. (medlineplus.gov)

Consequently, the phrase "anemia in the elderly" has come into use, indicating that anemia in an elderly patient mandates a workup to identify correctable causes of anemia, so that treatment can prevent the resulting morbidity and mortality. (medscape.com)
To date, no randomized studies were conducted to analyze whether the morbidity and/or mortality rates in SP patients correlate with the increased red blood cell volume and thrombosis 7 . (nature.com)
To reduce morbidity and mortality as a result of uncontrolled hemorrhage, patients needing a massive transfusion, specifically addressed in detail later in this chapter, must be quickly identified so that immediate interventions can prevent the development of the lethal triad of coagulopathy, hypothermia, and acidosis. (medscape.com)
IntroductionRheumatic diseases are autoimmune, inflammatory diseases often associated with cardiovascular (CV) disease, a major cause of mortality in these patients. (researchgate.net)
Patients with CKD and an insufficient hemoglobin response to ESA therapy may be at even greater risk for cardiovascular reactions and mortality than other patients. (takeda.com)
Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)

The increment in erythrocyte mass in SP patients results from bone marrow stimulation by EPO or abnormal functioning of the mutant EPO receptor. (nature.com)
[ 5 ] In dialysis and kidney transplant patients, hyperphosphatemia is associated with anemia independent of other mineral bone disease components. (medscape.com)

FOSTER CITY, Calif.--( BUSINESS WIRE )--Geron Corporation (Nasdaq: GERN), a late-stage clinical biopharmaceutical company, today announced poster presentations of data from IMerge, the Company's Phase 3 clinical trial evaluating its first-in-class investigational telomerase inhibitor imetelstat vs. placebo in patients with lower risk myelodysplastic syndromes (MDS) at the eleventh annual Society of Hematologic Oncology Annual Meeting (SOHO) held in Houston, Texas and virtually. (businesswire.com)

Polycythemia vera (PV) and secondary polycythemia (SP) are hematological diseases characterized by erythropoiesis exacerbation. (nature.com)
To reveal the risk factors, the symptom distribution characteristics, the clinical values of white blood cell counts (WBC counts), red blood cell distribution width (RDW), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and monocyte-to-lymphocyte ratio (MLR) in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with depression and/or anxiety. (dovepress.com)

Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
8 , 12 Ferritin is also an acute phase reactant and can be elevated in patients with chronic inflammation or infection. (aafp.org)
In patients with chronic inflammation, iron deficiency anemia is likely when the ferritin level is less than 50 ng per mL (112.35 pmol per L). 7 Ferritin values greater than or equal to 100 ng per mL (224.70 pmol per L) generally exclude iron deficiency anemia. (aafp.org)
Inflammation affects three major steps essential for normal erythropoiesis and can, therefore, lead to the development of anemia of inflammation. (haematologica.org)
Hyperphosphatemia is associated with inflammation and may affect normal cellular physiology including erythropoiesis. (medscape.com)

Patients share chronic anemia of variable severity and jaundice, frequently associated with splenomegaly and/or hepatomegaly. (orpha.net)

Erythropoiesis is always dysfunctional, as revealed by cellular anomalies and erythroid hyperplasia. (orpha.net)

These findings indicate a need for increased vigilance for hemolytic events in malaria patients, particularly those with predisposing factors for anemia. (cdc.gov)

The study cohort consisted of patients with new-onset transfusion dependence (TD). (aamds.org)
All patients received an ESA at least once during the study period, which began the week that criteria for TD were met and continued until transfusion independence (TI). (aamds.org)
In this observational, population-based study, variations in ESA administration impacted response in transfusion-dependent MDS patients, with higher response rates with early administration and use of darbepoetin, and low response likelihood in non-responders beyond 16 weeks of therapy. (aamds.org)
Hemoglobin is very low and patients are transfusion dependent. (wikipedia.org)
To be eligible for IMerge Phase 3, patients were required to be transfusion dependent, defined as requiring at least four units of packed red blood cells (RBCs), over an eight-week period during the 16 weeks prior to entry into the trial. (businesswire.com)
The primary efficacy endpoint of IMerge Phase 3 is the rate of red blood cell transfusion independence (RBC-TI) lasting at least eight weeks, defined as the proportion of patients without any RBC transfusion for at least eight consecutive weeks since entry to the trial (8-week TI). (businesswire.com)

The latter are approved for the treatment of patients with symptomatic anemia caused by palliative chemotherapy to reduce the number of RBC transfusions and gradually improve anemia-related symptoms. (springermedizin.at)
In some patients with cancer, causes of anemia remain unclear or are inevitable (e.g., myelotoxic chemotherapy). (springermedizin.at)
This short review focuses on indications, advantages, and risks of ESAs in patients with chemotherapy-associated anemia that develops during treatment of nonhematologic malignancies. (springermedizin.at)
In another study, 187 patients receiving chemotherapy and with serum ferritin of greater than or equal to 100 ng/dl or TfSat of greater than or equal to 15% were randomized to EPO without iron, oral iron or intravenous iron. (medscape.com)
There is a need for further investigation into the effects of and guidelines for exercise interventions (especially strength training) in this population of patients, particularly among cancer patients who are undergoing or have undergone chemotherapy or radiation treatments. (karger.com)
Dimeo F, Schwartz S, Fietz T, Wanjura T, Boning D, Thiel E: Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. (karger.com)
Dimeo FC, Tilmann MH, Bertz H, Kanz L, Mertelsmann R, Keul J: Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. (karger.com)
They are approved in the U.S. to treat anemia in cancer patients undergoing chemotherapy. (yourlawyer.com)
Patients undergoing chemotherapy had a 10% increased risk of dying. (yourlawyer.com)

Many cancer patients require therapeutic intervention to correct the underlying anaemia. (nature.com)
Therapeutic phlebotomy is used to remove excess iron and maintain low normal body iron stores in patients with hemochromatosis. (aetna.com)
Time in Therapeutic Range and Outcomes After Warfarin Initiation in Newly Diagnosed Atrial Fibrillation Patients With Renal Dysfunction. (janusinfo.se)
As we anticipated, there is interest from some of the world's leading dialysis providers to offer a new therapeutic option for the treatment of anemia in chronic kidney disease patients on dialysis," said Nicole Mowad-Nassar, vice president, marketing at Takeda. (takeda.com)

Study the HBS1L-MYB (rs4895441 and rs9376090) genetic polymorphisms in Egyptian patients with β -thalassemia major and sickle cell disease and its relation to Hb F and severity of the disease. (scirp.org)

In the present study prohepcidin levels were determined in the serum of hemodialysis (HD) patients and its correlations with iron metabolism markers, C-reactive protein (CRP) and hematocrit (Hct) were assessed. (uth.gr)
Results: In comparison to the healthy volunteers, the HD patients had higher serum ferritin, transferrin receptors and CRP, lower serum iron and similar transferrin saturation and prohepcidin levels. (uth.gr)
17% of the patients had serum ferritin levels of less than 100 ng/ml, 59% had TfSat of less than 20% and 27% had CHr of less than 32 g/dl. (medscape.com)
2 , 6 - 11 A serum ferritin level should be obtained in patients with anemia and a mean corpuscular volume less than 95 μm 3 . (aafp.org)
[ 17 ] Another study of kidney transplant patients showed that a one standard deviation higher of serum phosphorous level (0.8 mg/dL) was associated with 77% greater odds for anemia. (medscape.com)
We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). (who.int)
Full blood count, serum ferritin, soluble transferring receptor, C-reactive protein, serum iron and total iron binding capacity were measured in the patients and healthy controls. (bvsalud.org)

If you are a dialysis patient, aspirin may also be given to stop your dialysis access becoming blocked. (kidney.org.uk)

In this sense, we examined whether analysis of the cytokine production profile of SP and PV patients would help to distinguish them, despite their clinical similarities. (nature.com)
Baseline data and clinical measurement data [spirometry, arterial blood gas analysis, and COPD evaluation test (the CAT scale)] from patients with AECOPD were collected. (dovepress.com)
The term Nontransfusion dependent thalassaemia (NTDT) was suggested to describe patients who had clinical manifestations that are too severe to be termed minor yet too mild to be termed major. (hindawi.com)
Nontransfusion-dependent thalassemia (NTDT), as its name implies, is a term coined to describe those patients that do not require lifelong transfusions who instead may need emergent transfusions for specific clinical settings [ 8 ]. (hindawi.com)
If there is insufficient relief of symptoms in such patients, the dose may be cautiously increased to 1200 mg, but only with close monitoring [see CLINICAL PHARMACOLOGY ]. (globalrph.com)
Bergqvist J, Iderberg H, Mesterton J, Bengtsson N, Wettermark B, Henriksson R. Healthcare resource use, comorbidity, treatment and clinical outcomes for patients with primary intracranial tumors: a Swedish population-based register study. (janusinfo.se)
In controlled clinical trials of ESAs in patients with cancer, increased risk for death and serious adverse cardiovascular reactions was observed. (takeda.com)
these patients is commonly avoided in screening method [9] and confirmed Statistical significance was accepted clinical practice. (who.int)

Patient blood management (PBM) is a multidisciplinary and patient-centered treatment approach, comprising the detection and treatment of anemia, the minimization of blood loss, and the rational use of allogeneic transfusions. (karger.com)
Patients who have anemia or sickle cell anemia are at increased risk for postoperative complications, including the need for blood transfusions and delayed healing. (lww.com)
however, these patients can be optimized using preoperative red blood cell transfusions to dilute sickle cells and elevate the hemoglobin level. (lww.com)
Despite known safety risks, drugs like Procrit continue to be used because it is believed that they help reduce the number of blood transfusions some cancer patients need, while improving quality of life. (yourlawyer.com)
The report, published in the April 30 online edition of the Canadian Medical Association Journal, concluded that ESAs should not routinely be used as an alternative to blood transfusions in patients with anemia related to cancer. (yourlawyer.com)
Those patients are not entirely dependent on transfusions for survival. (hindawi.com)
Patients who carry the trait are often asymptomatic and continue to live a normal life, while β -thalassemia major patients suffer from many complications that may be ameliorated due to lifelong transfusions. (hindawi.com)
OMONTYS is not indicated, and is not recommended, for use in patients with CKD not on dialysis, in patients receiving treatment for cancer and whose anemia is not due to CKD, or as a substitute for red blood cell (RBC) transfusions in patients who require immediate correction of anemia. (takeda.com)
Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. (who.int)
Sur 75 patients, 44 n'avaient jamais été transfusés, 31 avaient reçu des transfusions sanguines mais pas dans les trois mois précédents l'étude. (who.int)

Overall, the present study demonstrated a correlation between oxidative stress levels and the response to ESA treatment in lower-risk MDS patients, with the plasmatic peroxides levels a good predictive biomarker of drug (ESA) response. (uc.pt)
Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)

Reactive oxygen species (ROS) generation in NTDT patients is caused by 2 major mechanisms. (hindawi.com)

Daprodustat for the Treatment of Anemia in Patients Undergoing Dialysis. (nih.gov)
OMONTYS was approved by the FDA on March 27, 2012, for the treatment of anemia due to CKD in adult patients on dialysis. (takeda.com)

Anemia and its resulting symptoms like fatigue have a great impact on the quality of life (QoL) of patients suffering from cancer. (springermedizin.at)
Although the physiopathology of SP and PV is distinct, patients with these diseases share similar symptoms. (nature.com)
While not a curative option, ruxolitinib offers great palliative potential and results in significant reduction in splenomegaly and improvement in constitutional symptoms in the majority of treated patients, thus improving their quality of life and performance status. (cancernetwork.com)
Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity. (drugs.com)
Of the 307 patients with AECOPD included, 63.5% (N=195) had depressive and/or anxiety symptoms, and 36.5% (N=112) had no symptoms. (dovepress.com)

Patient-reported outcomes (PRO) data reported a sustained meaningful improvement in fatigue for imetelstat-treated patients vs. placebo. (businesswire.com)

Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction, blood loss, or a combination of these factors. (msdmanuals.com)

These results may have implications for future metabolomics research in this patient cohort. (mdpi.com)
Forslund T, Wettermark B, Andersen M, Hjemdahl P. Stroke and bleeding with NOAC or warfarin treatment in patients with non-valvular atrial fibrillation: a population based cohort study. (janusinfo.se)

Hypoxia -inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are a new class of medications for managing renal anemia in patients with chronic kidney disease (CKD). (bvsalud.org)

There is also 'functional failure' due to retention of iron in macrophages and decreased iron availability for erythropoiesis despite adequate iron stores in the reticuloendothelial system. (medscape.com)
As opposed to thalassemia major, where transfusional induced iron overload is targeted towards the reticuloendothelial system and parenchyma, iron is amassed in patients with NTDT that differ, primarily occurs in hepatocytes [ 10 - 13 ]. (hindawi.com)

Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
Patients with severe renal impairment or on dialysis should also initiate therapy with 600 mg once daily. (globalrph.com)

BACKGROUND: Erythropoiesis-stimulating agent (ESA)-hyporesponsive anemia is common in chronic kidney disease (CKD). (ox.ac.uk)
In this article, we provide updated data on ruxolitinib therapy for patients with myelofibrosis and offer expert opinion on the appropriate use of this agent in the community practice. (cancernetwork.com)
Additionally, ruxolitinib is the only agent that has demonstrated a survival benefit in patients with MF. (cancernetwork.com)
OMONTYS is the only once-monthly erythropoiesis-stimulating agent (ESA) for anemia available to this patient population in the United States. (takeda.com)
Collectively, they support the efficacy of roxadustat in achieving and maintaining target hemoglobin levels between 10 to 12 g/dL in patients with symptomatic anemia associated with CKD regardless of dialysis status and irrespective of prior treatment with an erythropoiesis-stimulating agent. (medscape.com)

Patients with vs. without protein-energy wasting syndrome had a significantly lower mean hemoglobin level. (renalandurologynews.com)

In sickle cell disease patients, Genetic polymorphisms in HBS1L-MYB (rs9376090 & rs4895441) affect the level of Hb F which could improve the prognosis of these patients. (scirp.org)
ABSTRACT Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. (who.int)

Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. (drugs.com)
In patients without one of those indications for dialysis, initiating renal replacement therapy (RRT) prophylactically offers no benefit over performing RRT as and when required. (medscape.com)

0.001), and cellular GR activity (p = 0.001) when compared to patients who did not respond to ESA treatment. (uc.pt)

The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes. (elifesciences.org)
They looked at the findings from 53 cancer trials that included a total of almost 14,000 patients. (yourlawyer.com)
Imaging findings and cognitive function in glioblastoma patients. (lu.se)

If the patient has a decline in his or her ability to ambulate or in his or her ADL function, and if he or she may benefit from a rehab stay at a Skilled Nursing Facility (SNF) or Acute Rehab Facility (ARU), please consult PT/OT early to assist in determining a more appropriate next level of care for the patient, prior to eventually returning home. (uclahealth.org)
Schmidt-Mende K, Andersen M, Wettermark B, Hasselström J. Educational intervention on medication reviews aiming to reduce acute healthcare consumption in elderly patients with potentially inappropriate medicines -A pragmatic open-label cluster randomized controlled trial in primary care. (janusinfo.se)
The first step in the management of acute tubular necrosis (ATN) is identification of patients at risk for it. (medscape.com)

Furthermore, we demonstrate that administration of the Ac inhibitor carmofur to wildtype mice has similar effects on P. yoelii infection and erythropoiesis. (elifesciences.org)

The early differential diagnosis may improve the quality of life and decrease the disease burden in PV patients, as well as enable curative treatment for SP patients. (nature.com)

In the patient group prohepcidin levels were negatively correlated with Hct but not with any other of the examined parameters. (uth.gr)
Conclusions: Taking into account the low Hct levels in the HD patients of our study, it seems plausible that the prohepcidin levels assessed in this group are inappropriately high. (uth.gr)
Further studies are warranted to determine whether pentoxifylline therapy represents a safe strategy for increasing hemoglobin levels in patients with CKD with ESA-hyporesponsive anemia. (ox.ac.uk)
PV is considered an oncoinflammatory disease because PV patients exhibit augmented levels of several pro-inflammatory cytokines. (nature.com)
Here we reported that SP patients exhibited decreased plasma levels of, IL-17A, IFN-γ, IL-12p70 and TNF-α when compared with PV patients, suggesting that analysis of the cytokine production profile may be an useful diagnostic biomarker to distinguish PV from SP patients. (nature.com)
In contrast to PV patients, SP patients do not have increased leukometry, platelet levels or splenomegaly. (nature.com)
One small study with 67 patients with lymphoproliferative diseases and hemoglobin levels between 9 and 11 g/dl has also demonstrated an increase in hemoglobin levels with the use of parenteral iron, along with decreased global need for EPO. (medscape.com)
ACD) 1 which is caused by negative effects of an activated immune system at different levels of erythropoiesis. (haematologica.org)

CDA I patients have a moderate macrocytic anemia with frequent splenomegaly and occasional hepatomegaly. (orpha.net)

This study provides evidence that murine acid ceramidase (Ac) is required for normal erythropoiesis and the development of rodent malaria. (elifesciences.org)

Anemia is a common finding in patients with solid or hematological malignancies. (springermedizin.at)

The complete results from a 5-year open-label extension study of Nplate in the adult chronic ITP setting show that Nplate increases and sustains platelet counts in these patients and that adverse event rates were consistent with those reported in previous studies," said Sean Harper, M.D., senior vice president, Global Development and Chief Medical Officer at Amgen. (amgen.com)

Two more studies have found that anemia drugs like Epogen, Procrit and Aranesp raise the risk of death among cancer patients. (yourlawyer.com)
Last summer, the Food & Drug Administration (FDA) ordered the labeling changes because several studies have shown that Procrit and other ESAs increased tumor growth and shortened survival time in some cancer patients. (yourlawyer.com)

Anatomy19

Organisms3

Diseases23

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes17

Anthropology, Education, Sociology and Social Phenomena1

Response to Erythropoiesis-Stimul2

Characterized by ineffective erythropoiesis3

Ineffective erythropoiesis3

Hemodialysis patients5

Erythropoietin9

Including erythropoiesis-stimul1

Inhibit erythropoiesis2

Hemolysis8

Refractory1

Hematopoietic4

Agents10

Anemic4

Cancer patients receiving ch2

Epoetin5

Mortality6

Bone2

Myelodysplastic1

Exacerbation2

Inflammation5

Chronic Anemia1

Hyperplasia1

Hemolytic1

Transfusion6

Chemotherapy9

Therapeutic4

Severity1

Serum7

Dialysis patient1

Clinical8

Transfusions10

Oxidative2

Reactive oxygen1

Treatment of anemia2

Symptoms5

Outcomes1

Hematocrit1

Cohort2

Hypoxia1

Reticuloendothelial system2

Severe2

Agent5

Hemoglobin level1

Sickle cell di2

Renal2

Cellular1

Findings3

Acute3

Infection1

Decrease1

Levels8

Splenomegaly1

Normal1

Hematological malignancies1

Adult1

Procrit2