• Beginning July 2000, Janssen Pharmaceutica will no longer be marketing cisapride (Propulsid). (drgreene.com)
  • tell your doctor if you are taking astemizole (Hismanal) (not available in the U.S.), cisapride (Propulsid) (not available in the U.S.), dihydroergotamine (DHE 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), pimozide (Orap), or terfenadine (Seldane) (not available in the U.S.). Your doctor will probably tell you not to take erythromycin if you are taking one or more of these medications. (medlineplus.gov)
  • Propulsid (cisapride) is a "prokinetic" agent that increases muscle contractions of the lower esophagus and the lower esophagus sphincter used to treat gastric reflux (the regurgitation of stomach acid into the esophagus), which is usually experienced as heartburn . (rxlist.com)
  • Our Propulsid (cisapride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Generic name: cisapride [ SISS-a-pride ] Brand name: Propulsid Drug class: GI stimulants. (urlbacklinks.com)
  • Cisapride is available under the following different brand names: Propulsid What Are Dosages of Cisapride? (urlbacklinks.com)
  • Since cisapride has been discontinued in human medicine, the pharmaceutical company that used to market it under the trade name "propulsid" has decided to stop making it available. (github.io)
  • Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, cisapride. (nih.gov)
  • Coadministration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4 such as cisapride, astemizole, pimozide, quinidine, and erythromycin are contraindicated in patients receiving fluconazole (see sections 4.4 and 4.5). (tajgenerics.com)
  • The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics. (nih.gov)
  • Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride. (nih.gov)
  • Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. (nih.gov)
  • Interindividual variations in the absorption of erythromycin are, however, observed, and some patients do not achieve optimal serum levels. (nih.gov)
  • 2, 3 Erythromycin, which has motilin analogue properties, is also of some value in a subset of patients. (bmj.com)
  • QT prolongation, torsades de pointes (cisapride removed from us market) (sometimes with syncope), cardiac arrest, and sudden death have been reported in patients taking cisapride without the above-mentioned contraindicated drugs. (rxlist.com)
  • A conference drawing together psychologists, social workers and scientists will hear evidence this week that a drug called cisapride - used to treat digestive problems and now withdrawn from the UK market - has resulted in hundreds of cases of wrong diagnosis. (newmediaexplorer.org)
  • It will hear calls for a full investigation into cisapride, which was withdrawn in the US and the UK three years ago after it was linked to 136 deaths worldwide, including those of two British children. (newmediaexplorer.org)
  • Cisapride was withdrawn from the human market because when it was combined with any of several commonly prescribed drugs, heart rhythm disturbances ensued. (vin.com)
  • Toremifene should not be prescribed to patients with congenital/acquired QT prolongation, uncorrected hypokalemia, or uncorrected hypomagnesemia. (drugs.com)
  • During post-marketing surveillance, there have been very rare cases of QT prolongation and torsade de pointes in patients taking fluconazole. (tajgenerics.com)
  • Because of its effect on smooth muscle contraction, cisapride can also be used in urinary retention situations to strengthen bladder contraction. (vin.com)
  • The key to treating most patients with constipation is correction of dietary deficiencies. (medscape.com)
  • If the patient experiences further episodes of constipation, a more detailed evaluation may then become appropriate (see Workup ). (medscape.com)
  • [ 20 ] Surgical intervention for constipation should be avoided in a patient with an underlying psychiatric cause. (medscape.com)
  • An international expert consensus (Delphi Survey) established five symptoms and their severities to define treatment failure to provide adequate relief in patients with chronic constipation. (medscape.com)
  • The key to treating most patients with constipation is correction of dietary deficiencies, which generally involves increasing intake of fiber and fluid and decreasing the use of constipating agents (eg, milk products, coffee, tea, alcohol). (medscape.com)
  • In March 2001, we urged the Food and Drug Administration (FDA) not to approve tegaserod (Zelnorm) because it was only marginally effective in treating constipation-predominant diarrhea in patients with irritable bowel syndrome and because of serious safety concerns. (citizen.org)
  • This drug is also preferred as a preventive medication in patients susceptible to fungal infections while undergoing chemotherapy or radiation therapy before bone marrow transplantation. (lybrate.com)
  • Cisapride is a prescription medication used for treating gastrointestinal dysmotility. (urlbacklinks.com)
  • Patients on oral hypoglycemics should be instructed to take their usual morning dose of hypoglycemic medication shortly before the radioactive meal. (henryford.com)
  • Even brisk walking may help stimulate bowel motility and, certainly, is unlikely to hurt most patients. (medscape.com)
  • Cisapride represents an improvement over metoclopramide in that the entire GI tract from stomach to colon can gain improved motility. (vin.com)
  • It is particularly helpful in patients who have adverse neurologic reactions to metoclopramide but still require stomach motility treatment. (vin.com)
  • Cisapride has been found helpful in some cases of megaesophagus and is a common treatment for feline megacolon . (vin.com)
  • tell your doctor and pharmacist if you are allergic to cisapride or any other drugs. (medlineplus.gov)
  • Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. (drugs.com)
  • Minor) Zafirlukast inhibits the CYP2C9 isoenzymes and should be used cautiously should be used cautiously in patients stabilized on drugs metabolized by CYP2C9, such as ibuprofen. (pdr.net)
  • Cisapride enhances the sedating properties of the benzodiazepine drugs (such as diazepam or alprazolam ). (vin.com)
  • Cisapride works less well with the concurrent use of medications with anticholinergic side effects (antihistamines, some heart medications, some psychoactive drugs). (vin.com)
  • Many of these patients also took drugs expected to increase cisapride blood levels by inhibiting the cytochrome P450 3A4 enzymes that metabolize cisapride. (rxlist.com)
  • Cisapride is contraindicated in patients taking any of these drugs. (rxlist.com)
  • AIDS patients are more prone to the development of severe cutaneous reactions to many drugs. (tajgenerics.com)
  • Children who are receiving the investigationally dispensed cisapride must be followed by a GI (gastrointestinal) specialist in addition to their regular doctor. (drgreene.com)
  • We pointed out that cisapride, a gastrointestinal drug which also caused fainting and was taken off the market because of cardiac arrhythmias, also affected this same receptor in the heart. (citizen.org)
  • Fluconazole should not be used in patients with known hypersensitivity to fluconazole, to related azole compounds or to any of the excipients listed in section 6.1. (tajgenerics.com)
  • Co-administration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400 mg per day or higher based upon results of a multiple dose interaction study. (tajgenerics.com)
  • Fluconazole should be administered with caution to patients with liver dysfunction. (tajgenerics.com)
  • Fluconazole has been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. (tajgenerics.com)
  • In cases of fluconazole-associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex or age of patient has been observed. (tajgenerics.com)
  • Patients who develop abnormal liver function tests during fluconazole therapy must be monitored closely for the development of more serious hepatic injury. (tajgenerics.com)
  • Treatment of fluconazole should be immediately discontinued and the patient should consult a physician. (tajgenerics.com)
  • Patients have rarely developed exfoliative cutaneous reactions, such as Stevens-Johnson Syndrome and toxic epidermal necrolysis, during treatment with fluconazole. (tajgenerics.com)
  • If a rash develops in a patient treated for a superficial fungal infection which is considered attributable to fluconazole, further therapy with this agent should be discontinued. (tajgenerics.com)
  • If patients with invasive/systemic fungal infections develop rashes, they should be monitored closely and fluconazole discontinued if bullous lesions or erythema multiforme develop. (tajgenerics.com)
  • Fluconazole should be administered with caution to patients with these potentially proarryhthmic conditions. (tajgenerics.com)
  • These FDA guidelines do not prevent the widespread use of many of the medications, nor does it give the practitioner the information needed to adequately treat the patient. (ispub.com)
  • and patients who are using medications that may affect kidney function. (medscape.com)
  • These reports included seriously ill patients with multiple confounding risk factors, such as structural heart disease, electrolyte abnormalities and concomitant medications that may have been contributory. (tajgenerics.com)
  • The FDREST study demonstrated that patients who took COLM-SST ® (FDgard) on a daily and proactive basis 30 to 60 minutes before meals, along with commonly used off-label FD medications, compared to patients who took placebo along with commonly used off-label FD medications, experienced a statistically significant, rapid reduction of FD symptoms within 24 hours across the FD study population. (pharmiweb.com)
  • Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. (nih.gov)
  • We present the results of a double blind, placebo controlled, crossover study of ghrelin in gastric emptying in patients with diabetic gastroparesis. (bmj.com)
  • Ten insulin requiring diabetic patients (five men, six type I) referred with symptoms indicative of gastroparesis received a two hour infusion of either ghrelin (5 pmol/kg/min) or saline on two occasions. (bmj.com)
  • Ghrelin increases gastric emptying in patients with diabetic gastroparesis. (bmj.com)
  • Is Gastroparesis Found More Frequently in Patients with Cystic Fibrosis? (atlantichc.com)
  • Colchicine (anti-gout medicine) - patients with renal or hepatic impairment. (who.int)
  • metoclopramide and cisapride. (vin.com)
  • Furthermore, cisapride does not cross into the brain, thus providing an alternative for patients who experienced hyperexcitability on metoclopramide. (vin.com)
  • Metoclopramide also had the disadvantage of causing neurologic side effects in the occasional patient by virtue of its ability to act on the brain. (vin.com)
  • Decrease dosage in patients with impaired renal function. (cdc.gov)
  • Need to decrease dose in patients with renal impairment. (cdc.gov)
  • Dose adjustment is needed in patients with renal impairment. (lybrate.com)
  • Use with caution in patients with renal dysfunction ( see section 4.2). (tajgenerics.com)
  • Use is contraindicated in patients with hepatic impairment including hepatic cirrhosis as drug exposure is increased (see Contraindications). (pdr.net)
  • The patient should be informed of suggestive symptoms of serious hepatic effect (important asthenia, anorexia, persistent nausea, vomiting and jaundice). (tajgenerics.com)
  • Patients should be advised not to stop taking or decrease the use of other asthma treatments when starting zafirlukast unless otherwise directed by their health care prescriber. (pdr.net)
  • If zafirlukast is discontinued, hydrocodone plasma concentrations will decrease resulting in reduced efficacy of the opioid and potential withdrawal syndrome in a patient who has developed physical dependence to hydrocodone. (pdr.net)
  • Although preliminary data from 12 patients with sickle cell anemia showed a decrease in PAH, a larger clinical trial (n = 134) investigating the use of sildenafil for pulmonary hypertension in adults with sickle cell anemia was stopped early due to an increased risk of severe adverse effects, especially sickle cell pain crises, compared to placebo (38% vs. 8%, respectively). (empowerpharmacy.com)
  • The positive effects seen from cisapride in cats include accelerated gastric emptying of both liquids and solids, and a decrease in transit time. (github.io)
  • Cisapride works well by smoothening the digestive tract muscles. (github.io)
  • Risks outweighed the benefits and now cisapride must be obtained from a compounding pharmacy for veterinary use. (vin.com)
  • also, most veterinary patients see only one veterinary practice so the interaction issue is much easier to control for pets. (vin.com)
  • Cisapride enhances the sedating properties of alcohol (generally not a concern in veterinary patients). (vin.com)
  • Limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation. (pdr.net)
  • Perphenazine and amitriptyline hydrochloride is not approved for the treatment of patients with dementia-related psychosis. (drugs.com)
  • Older patients are usually more sensitive than younger adults to the effects of perphenazine and amitriptyline combination. (drugs.com)
  • Amitriptyline is used to treat depression that is causing sadness, low mood, and loss of interest in patients. (tabletwise.net)
  • Read the directions on the product label, patient guide, or medicine guide provided by the medicine company or your pharmacist before starting to use Amitriptyline . (tabletwise.net)
  • If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. (pdr.net)
  • If zafirlukast is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. (pdr.net)
  • It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. (drugs.com)
  • According to an article in the Observer today, cisapride, a drug that has been linked to deaths world wide is also implicated in many of the apparent 'child abuse' cases that are being reviewed in the UK. (newmediaexplorer.org)
  • Given the amount of cases where cisapride has played a significant part in the child's treatment and the child's parents have been diagnosed as having MSBP, it is imperative the Government launches an investigation into this drug,' said Penny Mellor an anti-MSBP campaigner. (newmediaexplorer.org)
  • Patients receiving this drug should be informed by the physician of the risk and should be closely monitored. (nih.gov)
  • Assess patients for risks of addiction, abuse, or misuse before drug initiation, and monitor patients who receive benzodiazepines routinely for development of these behaviors or conditions. (pdr.net)
  • To discourage abuse, the smallest appropriate quantity of the benzodiazepine should be prescribed, and proper disposal instructions for unused drug should be given to patients. (pdr.net)
  • 1 Impaired gastric emptying in diabetic patients can be associated with a number of possible metabolic consequences: poor glycaemic control, increased risk of postprandial hypoglycaemia, and variable drug absorption. (bmj.com)
  • Inserting a product disclaimer does not increase drug safety for children because it does not give any information to the patient other than the fact that risks and side effects in children are unknown. (ispub.com)
  • 1 After thorough consideration of the learned intermediary doctrine in light of the current state of the prescription drug industry and physician/patient relationships, we decline to adopt this doctrine. (findlaw.com)
  • However, elderly patients are more likely to have age-related liver problems, which may require caution and an adjustment in the dose for patients receiving toremifene. (drugs.com)
  • Metronidazole is not recommended for use by patients with liver disease. (livestrong.com)
  • Some patients had no obvious risk factors for liver disease. (nih.gov)
  • ZOMITRA 100MG should be taken with caution in patients with severe liver disease. (crinovahealthcare.com)
  • If you have issues with the health of your liver, a low dose will usually be prescribed to elderly patients. (tabletwise.net)
  • In part 1, we summarize the causes and outcomes of perioperative cardiac arrest, review concepts in resuscitation of the perioperative patient, and propose a set of algorithms to aid in the prevention and management of cardiac arrest during the perioperative period. (medscape.com)
  • Cisapride is used to treat symptoms of nighttime heartburn in people who have not responded to other treatments. (medlineplus.gov)
  • Advise patients to seek immediate medical attention if they experience symptoms such as trouble breathing. (pdr.net)
  • Sildenafil is a vasoactive agent that is commonly prescribed to treat erectile dysfunction (impotence) in men, and to reduce symptoms in patients with pulmonary arterial hypertension (PAH). (empowerpharmacy.com)
  • Not only can FD patients make progress toward normalizing their nutrient intake and uptake, but they now also can deal with the anticipatory anxiety of FD symptoms by taking FDgard before their meals. (pharmiweb.com)
  • In addition, the patient must rarely have loose stools present without use of a laxative and must not meet Rome IV criteria for irritable bowel syndrome (IBS). (medscape.com)
  • Cisapride increases the rate at which your esophagus, stomach, and intestines move during digestion. (urlbacklinks.com)
  • Cisapride may cause side effects. (medlineplus.gov)
  • Cisapride is not able to cross the blood-brain barrier and thus cannot cause such side effects. (vin.com)
  • Older patients may see an increase in the incidence of side-effects with this medicine. (tabletwise.net)
  • and Myleran, or busulfan, an alkylating agent for patients with chronic myelogenous leukemia. (livestrong.com)
  • Delayed gastric emptying occurs in up to 50% of patients with chronic diabetes and is associated with significant impairments in both quality of life and diabetic control. (bmj.com)
  • Such an eventuality might occur in patients institutionalized in nursing homes or in chronic care facilities who require medical consultations to rule out conditions that are more serious. (medscape.com)
  • Coadministration with venetoclax is contraindicated in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) during the dose initiation and ramp-up phase of venetoclax. (guidelinecentral.com)
  • SPORANOX ® (itraconazole) Capsules should not be administered for the treatment of onychomycosis in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF. (guidelinecentral.com)
  • 3] Despite its frequency, it often remains unrecognized until the patient develops sequelae, such as anorectal disorders. (medscape.com)
  • Most patients had disorders that may have predisposed them to arrhythmias with cisapride. (rxlist.com)
  • Cisapride comes as a tablet and liquid to take by mouth. (medlineplus.gov)
  • The starting dose of cisapride is one 10 mg tablet or 10 ml of the suspension 4 times daily at least 15 minutes before meals and at bedtime. (rxlist.com)
  • Most of these cases occurred in patients with known risk factors. (drgreene.com)
  • A potential risk of abuse should not preclude appropriate treatment in any patient, but requires more intensive counseling and monitoring. (pdr.net)
  • The patient is at a high risk for becoming dependent on laxatives and developing a laxative colon. (medscape.com)
  • Stsegment and twave inversion, of these patients had underlying anatomic or vascular risk factors for development of naion unrelated to PDE5 use. (ultimateunderground.com)
  • Cisapride: Risk of prolonged QT interval. (pediatriconcall.com)
  • Always read the patient information leaflet before using this medicine. (travelpharm.com)
  • A randomised comparison of the effect of three patient information leaflet models on older patients' treatment intentions. (mcmaster.ca)
  • The withdrawal of cisapride leaves medical professionals with the task of prescribing a ppropriate alternative therapy for patients. (github.io)
  • Papaverine may reduce tolerance to cold temperatures in elderly patients. (mayoclinic.org)
  • Patients with heart failure, leg swelling, hearing loss, neuropathy and lung edema should be extremely cautious while taking Itraconazole. (medindia.net)
  • Pediatric patients with pseudo-obstruction and neonates with feeding intolerance may also be considered. (drgreene.com)
  • Talk to your doctor or pharmacist about whether you should be taking cisapride. (medlineplus.gov)
  • Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients. (medlineplus.gov)
  • Note: may need higher dose in patients with central nervous system disease. (cdc.gov)