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  • immune
  • A 2nd generation small molecule TPO-agonist, eltrombopag (Promacta ) has been shown to increase platelets in healthy subjects and in thrombocytopenic patients with chronic immune thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infection. (clinicaltrials.gov)
  • Eltrombopag received FDA accelerated approval on Nov 20, 2008 for the treatment of thrombocytopenia in patients with chronic immune (idiopathic) thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. (clinicaltrials.gov)
  • A 2nd generation small molecule TPO-agonist, eltrombopag (Promacta(Registered Trademark)) has been shown to increase platelets in healthy subjects and in thrombocytopenic patients with chronic immune thrombocytopenic purpura (ITP) and hepatitis C virus (HCV) infection. (comparetrials.com)
  • Oral Mucositis
  • OBJECTIVES: I. Determine whether low-energy laser therapy can prevent oral mucositis in patients undergoing bone marrow transplantation. (knowcancer.com)
  • In this study the duration and severity of oral mucositis, and requirements for opioid medication, were evaluated in 95 patients undergoing bone marrow transplantation. (wikipedia.org)
  • Patients were instructed to rinse 4 times per day at the start of cancer treatment and up to 10 times per day if they developed severe oral mucositis. (wikipedia.org)
  • The results showed: More than twice as many bone marrow transplant patients avoided oral mucositis by using Caphosol Duration of oral mucositis was almost halved in patients using Caphosol Caphosol patients used 72% less morphine for pain relief, with nearly 75% of patients requiring no morphine at all. (wikipedia.org)
  • Caphosol has also been associated with low occurrence and severity of oral mucositis in a registry of cancer patients. (wikipedia.org)
  • The registry data provide further evidence to support the use of Caphosol to treat oral mucositis and suggest that Caphosol is associated with a low occurrence and severity of oral mucositis with high adherence to treatment as well as high levels of satisfaction from both patients and physicians. (wikipedia.org)
  • Patients at risk of oral mucositis were given Caphosol and instructed to rinse 4-10 times daily depending on the severity of the mucositis. (wikipedia.org)
  • Patients and physicians completed questionnaires on the symptoms of oral mucositis, mucositis severity and satisfaction with the treatment. (wikipedia.org)
  • The results showed that 88% of patients receiving chemotherapy and/or radiotherapy for head and neck cancer who had used Caphosol experienced no or low grade (mild-moderate) oral mucositis, and 44% experienced mild or no oral pain. (wikipedia.org)
  • THERAPY
  • Patients on both arms with CNS disease at presentation receive CNS therapy comprising hydrocortisone (HC) IT and MTX IT alternating with cytarabine (ARA-C) IT twice a week until CSF clears. (clinicaltrials.gov)
  • Patients with CNS disease at presentation receive CNS therapy comprising HC IT and MTX IT alternating with ARA-C weekly for 6 weeks. (clinicaltrials.gov)
  • Among the patients evaluated for early toxicity, fatal toxicity rate was significantly higher in the gemtuzumab combination therapy group vs the standard therapy group. (wikipedia.org)
  • Later in August 2014, this Administration approved Velcade for the retreatment of adult patients with multiple myeloma who had previously responded to Velcade therapy and relapsed at least six months following completion of prior treatment. (wikipedia.org)
  • The definitive therapy is lung transplantation. (wikipedia.org)
  • The definitive therapy is lung transplantation, though transplant rejection is always a possibility, in this measures must be taken in terms of appropriate treatment and medication. (wikipedia.org)
  • Two randomized, placebo-controlled clinical trials, known as MOTIVATE 1 & 2, compared 209 patients receiving optimized therapy plus a placebo to 426 patients receiving optimized therapy plus 150 mg maraviroc once daily and 414 patients receiving optimized therapy plus 150 mg maraviroc twice daily. (wikipedia.org)
  • Tumor
  • Longer survival of beyond one year was reported in one patient and of up to eight years in one individual whose tumor was well circumscribed and non-metastatic at the time of diagnosis, suggesting that early detection could dramatically improve survival. (wikipedia.org)
  • Serious side effects included severe myelosuppression (suppressed activity of bone marrow, which is involved in formation of various blood cells [found in 98% of patients]), disorder of the respiratory system, tumor lysis syndrome, Type III hypersensitivity, venous occlusion, and death. (wikipedia.org)
  • GVHD
  • Patients receive GVHD prophylaxis with methylprednisolone IV every 12 hours on days 2-21, oral prednisone every 12 hours on days 22-100 and then tapered off over days 101 to 128, and cyclosporine IV over 2 hours every 8-12 hours on days -3 to 100. (clinicaltrials.gov)
  • Phase
  • PURPOSE: This phase II trial is studying the side effects of giving a bone marrow transplant together with chemotherapy and to see how well it works in treating patients with refractory non-Hodgkin's lymphoma, Hodgkin's lymphoma, or multiple myeloma. (clinicaltrials.gov)
  • The drug (PS-341) was tested in a small Phase I clinical trial on patients with multiple myeloma. (wikipedia.org)
  • Two open-label, phase II trials (SUMMIT and CREST) established the efficacy of bortezomib 1.3 mg/m2 (with or without dexamethasone) administered by intravenous bolus on days 1,4,8, and 11 of a 21-day cycle for a maximum of eight cycles in heavily pretreated patients with relapsed/refractory multiple myeloma. (wikipedia.org)
  • cancer
  • Chemotherapy-induced acral erythema (also known as palmar-plantar erythrodysesthesia, palmoplantar erythrodysesthesia, or hand-foot syndrome) is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer. (wikipedia.org)
  • refractory
  • In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease. (wikipedia.org)
  • regimen
  • In this study, we propose to prospectively evaluate the efficacy of a fludarabine- and antibody-based conditioning regimen in HCT for DC patients, with the goals of maintaining donor hematopoiesis and transfusion independence while decreasing early and late complications of HCT for DC. (knowcancer.com)
  • To determine feasibility, in terms of the proportion of patients who survive to Day+100 post-transplant, of a reduced intensity conditioning regimen in allogeneic HCT for BMF due to DC. (knowcancer.com)
  • In this protocol we will test whether a regimen that avoids DNA alkylators and radiation can permit successful BMT without compromising survival in patients with DC. (clinicaltrials.gov)
  • Symptoms
  • Symptoms of Richter's transformation in a CLL patient include fever (without infection), an elevated serum levels of lactate dehydrogenase, and rapidly enlarging lymph nodes. (wikipedia.org)
  • In a case series of 34 patients, Davis and colleagues reported the following signs and symptoms: macroscopically visible (gross) hematuria (60%) abdominal or back/flank pain (50%) significant weight loss (25%) Other researchers have reported a palpable renal mass or enlarged lymph nodes. (wikipedia.org)
  • therapy
  • In a recent Blood article, Anja Möricke , from the Department of Pediatrics at the Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, in Germany, and colleagues reported results from the open-label AIEOP-BFM ALL 2000 trial, which compared induction therapy with dexamethasone versus prednisone in 3,720 pediatric ALL patients. (ashclinicalnews.org)
  • Patients who have had radiation therapy in more than 35% of the bone marrow. (careacross.com)
  • however, some patients fail to respond to this cell therapy. (ahajournals.org)
  • Called the "Multicenter Study of Cryoablation for Palliation of Painful Bone Metastases", or MOTION, the study aims to assess the effectiveness and safety of cryoablation therapy to treat patients with painful bone metastases and document the effects the procedure has on their condition. (advancingyourhealth.org)
  • Among the patients evaluated for early toxicity, fatal toxicity rate was significantly higher in the gemtuzumab combination therapy group vs the standard therapy group. (wikipedia.org)
  • In a large study of 225 patients, 82% initially responded to this therapy, although many side effects were noted. (wikipedia.org)
  • laboratory
  • this disorder is a form of plasma cell dyscrasia in which no myeloma protein is detected in serum or urine (at least as determined by conventional laboratory methods) of individuals who have clear evidence of an increase in clonal bone marrow plasma cells and/or evidence of clonal plasma cell-mediated tissue injury (e.g. plasmacytoma tumors). (wikipedia.org)
  • Treatment
  • OUTLINE: Patients are assigned to 1 of 2 treatment arms. (clinicaltrials.gov)
  • After completion of study treatment, patients are followed up every 6 months for 2 years and then annually for 3 years. (clinicaltrials.gov)
  • HIV-infected patients 21 years of age and older with chronic hepatitis B infection and liver cirrhosis who have received lamivudine treatment for at least 1 year may be eligible for this 48-week study. (clinicaltrials.gov)
  • Patients who meet the study criteria and decide to participate will then start treatment with one 10-mg adefovir pill per day by mouth. (clinicaltrials.gov)
  • Monthly visits beyond week 48 - Based on the HBV response to treatment and the availability of the drug from the sponsor, patients may be offered to extend their treatment with adefovir. (clinicaltrials.gov)
  • Despite treatment with a protocol that results in better EFS despite similar OS, it is counterbalanced by a large proportion of patients who do not benefit from the intensified first-line treatment, but are subjected to the risk of more toxicity," Dr. Möricke and colleagues wrote. (ashclinicalnews.org)
  • Development of the new methods of treatment of children with acquired and inherited bone marrow failures. (fnkc.ru)
  • Aggressive treatment with antibiotics is required and bone marrow transplant is common. (wikipedia.org)
  • One ACI treatment, called Carticel, is designated for young, healthy patients with medium to large sized damage to cartilage and is not applicable to osteoarthritis patients. (wikipedia.org)
  • syndrome
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • liver
  • This study will evaluate the safety and effectiveness of adding the experimental drug adefovir dipivoxil to lamivudine for treating hepatitis B virus (HBV) infection in HIV-infected patients with liver cirrhosis. (clinicaltrials.gov)
  • chemotherapy
  • Since chemotherapy tolerance is lower in adult and adolescent patients - who generally experience more toxic effects compared with pediatric patients - we would be cautious with a general recommendation to treat adult patients with dexamethasone instead of prednisone in induction," she said. (ashclinicalnews.org)
  • However, the potential benefit of dexamethasone for adult ALL patients may depend on a number of other factors including the underlying chemotherapy regimen, the biologic ALL subset or clinical features. (ashclinicalnews.org)
  • 1997
  • In 1997, a patient was identified who carried a rare balanced chromosomal translocation involving chromosome 19 and the X chromosome. (wikipedia.org)
  • diagnostic
  • While some parts of the Queen Elizabeth University Hospital have their own distinct identity and dedicated specialist staff, such as the Royal Hospital for Children, each is completely integrated with linkages for patient transfer, diagnostic services, emergency care and even a rapid access lift from the emergency helicopter pad on the roof of the adult hospital. (wikipedia.org)
  • cells
  • Then these cells are injected into the patient. (wikipedia.org)
  • Diamond-Blackfan anemia is characterized by normocytic or macrocytic anemia (low red blood cell counts) with decreased erythroid progenitor cells in the bone marrow. (wikipedia.org)
  • Some previously undiagnosed relatives of DBA patients were found to carry mutations, and also had increased adenosine deaminase levels in their red blood cells, but had no other overt signs of disease. (wikipedia.org)
  • results
  • The results indicate that dexamethasone should not be used in the childhood ALL population and should only be used with caution in adult patients with ALL, according to Dr. Möricke. (ashclinicalnews.org)
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • Primary
  • Dr. Steward has recently obtained permission from the National Health Service in England to provide a national specialist service for the disease, primary aims of which will be to increase recognition of the disease and to provide more consistent quality of care for patients whilst minimizing hospital visits. (barthsyndrome.org)
  • 3. Primary bone sarcomas. (careacross.com)
  • hospital
  • Finally, the patient was discharged from the hospital on day 203 of the illness without sequelae except for a coronary aneurysm. (paperity.org)
  • pinyin: Táiběi Róngmín Zǒngyī Yuàn) is a national first class medical center and a teaching hospital which provides tertiary patient care, undergraduate medical education programs and residency programs in Taiwan. (wikipedia.org)
  • analysis
  • The researchers also performed a retrospective analysis of the clinical risk subgroups finding that, among patients with T-ALL, dexamethasone provided a significant survival benefit over prednisone. (ashclinicalnews.org)
  • common
  • Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. (wikipedia.org)
  • research
  • First Neurological Institute (Department of Neurology and Department of Neurosurgery) in Taiwan (1989), has been pioneering in neurocritical medicine, headache, cerebellar ataxia, dementia, neural regeneration and repair, and epilepsy research and patient care of the nation. (wikipedia.org)
  • Medical
  • 1 Despite recent advances in medical intervention, the symptoms of some patients with critical limb ischemia fail to be controlled. (ahajournals.org)
  • care
  • Be confident in your decisions by checking out your provider's top areas of care, education, patient reviews and more. (healthgrades.com)
  • Our efforts are focused on development of new multi-centre studies and clinical centers, education of young physicians and providing high-level care to our patients. (fnkc.ru)
  • Mutations
  • Patients who present with unique immunological phenotypes provide an opportunity to better understand defect-driving mutations. (jci.org)