• 2) Antilymphocyte Globulin (ALG) . (nanomedicine.com)
  • ALG is produced by immunizing a large animal such as a horse with human lymphocytes, then purifying the gamma globulin fraction of the serum. (nanomedicine.com)
  • In patients with Bruton-type agammaglobulinemia the percentage of cells sensitive to the antiserum was above normal (77-89%), whereas it was decreased in some patients with lepromatous leprosy or under antilymphocyte globulin therapy. (bvsalud.org)
  • Patients receiving in vivo antithymocyte globulin, Campath, or ex vivo T cell depletion were excluded. (unisr.it)
  • Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease. (1library.co)
  • this has created a theoretical basis for the use of antithymocyte globulin to target T cells in these patients. (elsevierpure.com)
  • We present a case of acute fulminant influenza B myocarditis in a pediatric patient that required mechanical circulatory support and improved only after treatment with antithymocyte globulin. (elsevierpure.com)
  • Name Anti-Human Lymphocyte Globulin Included Drug Anti-Human Lymphocyte Globulin (Generic Name) Anti-Human Lymphocyte Globulin LYMPHOCYTOTOXIC AUTOANTIBODIES Disease Association Lymphocytotoxic antibodies were first described in patients with infectious agents: bacteria (Mycobacterium tuberculosis, M. leprae), virus (Influenzae, herpes virus, Epstein-Barr virus), fungi and parasite. (pharmapedia.pk)
  • Background A combination of horse anti-thymocyte globulin and cyclosporine produces responses in 60-70% of patients with severe aplastic anemia. (haematologica.org)
  • Design and Methods Twenty patients with severe aplastic anemia treated with rabbit anti-thymocyte globulin were compared to 67 historical control cases with matched clinical characteristics treated with horse anti-thymocyte globulin. (haematologica.org)
  • Results Response rates at 3, 6 and 12 months were similar for patients treated with rabbit anti-thymocyte globulin or horse anti-thymocyte globulin: 40% versus 55% ( P =0.43), 45% versus 58% ( P =0.44) and 50% versus 58% ( P =0.61), respectively. (haematologica.org)
  • [ 1 ] Recipients were treated with intensive conventional immunosuppression , including combinations of prednisone , azathioprine , and antilymphocyte globulin. (medscape.com)
  • Human Rho(D) immune globulin is a solution of antibodies used to prevent isoimmunization of Rho(D) negative patients exposed to Rho(D) positive blood in pregnancy or transfusion. (drugbank.com)
  • Rho immune globulin increase platelet counts and reduce bleeding in Rho-positive patients with ITP by inhibiting autoantibody-mediated platelet clearance. (drugbank.com)
  • To date, there are no studies comparing patient and graft outcomes based on rabbit anti-thymocyte globulin (rATG) or IL-2 receptor antagonist (IL-2 RA) induction in this population. (atcmeetingabstracts.com)
  • Regular treatment for patients with aplastic anemia who have a matched sibling (brother or sister), or family donor is a bone marrow transplant. (ucsf.edu)
  • Typically, anemia refers to low red blood cell counts, but aplastic anemia patients have lower counts of all three blood cell types: red blood cells, white blood cells, and platelets, termed pancytopenia. (webdicine.com)
  • Aplastic anemia is present in up to 2% of patients with acute viral hepatitis. (webdicine.com)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • For patient education information, see What Is Aplastic Anemia? . (medscape.com)
  • Between 1963 and 1974, 36 patients underwent lung transplantation but only two recipients lived longer than a month. (clinicalgate.com)
  • The number of patients on the waiting list for lung transplantation in the United States is about 3500, 3 but only about 1000 patients undergo the procedure each year, resulting in a median waiting time of just over 3 years. (clinicalgate.com)
  • 2 Furthermore, because of the limited number of transplants performed, only a small proportion of patients who could benefit from lung transplantation are actually listed for surgery. (clinicalgate.com)
  • In the United States, approximately 15% of patients die each year while awaiting lung transplantation. (clinicalgate.com)
  • In this chapter the preoperative assessment and perioperative management of patients undergoing lung transplantation are reviewed, with emphasis on the early postoperative period. (clinicalgate.com)
  • Compliance with a pulmonary rehabilitation program is a prerequisite for lung transplantation in patients with chronic obstructive pulmonary disease (COPD) and has been shown to improve outcomes of surgery. (clinicalgate.com)
  • However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). (nih.gov)
  • Heterologous polyclonal antibodies are obtained from the serum of animals (e.g., rabbit, horse), and injected with the patient's thymocytes or lymphocytes. (wikipedia.org)
  • An antihuman T-cell has been prepared in rabbits by infecting lymphocytes from a patient with Bruton-type agammaglobulinemia and absorption with cultured B-lymphoblast cells. (bvsalud.org)
  • This anti-T-cell serum killed 66% (range 49-78) of normal blood lymphocytes. (bvsalud.org)
  • Lymphocytes have been identified as critical mediators of the early innate immune response to ischemia-reperfusion injury, and immunomodulation of lymphocytes may prevent secondary immunologic injury in surgical and trauma patients. (usuhs.edu)
  • Despite its frequent use and efficacy, the heterologous makeup of thymoglobulin can induce the immune system resulting in serum sickness which typically presents with rash, fever, fatigue, and poly-arthralgia in the weeks following drug exposure. (clinnephrologyjournal.com)
  • Herein, we present a case of a patient with a known history of thymoglobulin-induced serum sickness, who presented with evidence of acute cellular and vascular rejection at their 12-month post-operative visit. (clinnephrologyjournal.com)
  • To the author's knowledge, this is the first case report of successful administration of ATGAM in a patient with a documented history of thymoglobulin induced serum sickness, demonstrating a possible treatment option for acute rejection in patients with reactions to thymoglobulin. (clinnephrologyjournal.com)
  • Currently, thymoglobulin is the most commonly used induction agent in immunologically high risk renal transplant patients [1].Thymoglobulin is a polyclonal rabbit-derived antibody that causes lymphocyte depletion by acting at multiple antigenic sites, including molecules on the surface of T-cells and B-cells [2]. (clinnephrologyjournal.com)
  • Despite data that shows fewer rejection and better graft survival using antibody induction, serious side-effects of thymoglobulin have been reported, including cardiopulmonary decompensation, respiratory distress syndrome, hematologic disorders, and serum sickness. (clinnephrologyjournal.com)
  • A retrospective cohort study was performed in elderly patients (age 65 or older) who received either induction with rATG (thymoglobulin) or IL-2 RA (either basiliximab or daclizumab) between January 2001 and January 2015 at a single transplant center. (atcmeetingabstracts.com)
  • Steroids are generally ineffective, though are often used to combat serum sickness caused by ATG use. (webdicine.com)
  • Serum sickness classically occurs in the setting of exposure to heterologous (non-human) serum proteins causing deposition of antigen-antibody complexes in vessels or tissues, resulting in activation of the complement cascade and recruitment of immune cells, specifically neutrophils. (clinnephrologyjournal.com)
  • [ 1 ] Transplantation is the renal replacement modality of choice for patients with end-stage renal disease, especially those with diabetic nephropathy and pediatric patients. (medscape.com)
  • In addition to a thorough medical evaluation, evaluate the psychosocial issues of the patient to determine conditions that may jeopardize the outcome of transplantation, such as financial and travel restraints or a pattern of noncompliance. (medscape.com)
  • The medical workup may reveal circumstances that necessitate surgical intervention to prepare the patient for kidney transplantation. (medscape.com)
  • We analyzed data from a cohort of 889 first kidney graft recipients with ATG induction (86 with SSD [SSD(+)] and 803 without SSD [SSD(-)]) from the Données Informatisées et Validées en Transplantation data bank. (nih.gov)
  • Two subgroups of SSD(+) and SSD(-) patients that had received ATG induction treatment were then assessed for total anti-ATG, anti-Neu5Gc, and anti-Gal antibodies using ELISA assays on sera before and after transplantation. (nih.gov)
  • Unmanipulated haploidentical hematopoietic stem cell transplantation (HCT) with post-transplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis (haplo-PTCY) and unrelated double-unit umbilical cord blood transplantation (dUCBT) are feasible options for treating patients with high-risk acute myelogenous leukemia (AML). (unisr.it)
  • This study compared outcomes after dUCBT and haplo-HCT using peripheral blood stem cells (PBSCs) in adult patients with AML in complete remission (CR) who underwent transplantation in European Society for Blood and Marrow Transplantation (EBMT)-affiliated centers. (unisr.it)
  • All patients underwent transplantation with G-CSF-mobilize blood stem cells. (psu.edu)
  • However, the reality is that although kidney transplantation may have some consequences, it is almost the best treatment for kidney patients. (tebmedtourism.com)
  • Transplantation of patients with underlying cystic fibrosis (CF), whose native airways and sinuses are chronically infected with virulent bacterial pathogens, initially raised unique concerns about the potential excessive risk of postoperative infections. (ersjournals.com)
  • Two recent series from North American centres with extensive experience in transplantation of CF patients have documented 1-yr survival rates of 50% versus 83% and 67% versus 96% among CF patients with and without B. cepacia , respectively 7 , 8 . (ersjournals.com)
  • The introduction of TAC in 1990 improved actuarial graft and patient survival rates following all types of intestine transplantation. (medscape.com)
  • [ 9 ] The use of TAC as the primary immunosuppressant in small bowel transplantation as well as improved surgical techniques, the availability of an increased array of potent immunosuppressive medications, infection prophylaxis, and suitable patient selection have contributed to the reality of this procedure for a growing number of patients who are total parenteral nutrition (TPN)-dependent and have permanent intestinal failure. (medscape.com)
  • Malignancy prevalence in waitlisted potential kidney transplant recipients is very low relative to patients after kidney transplantation. (edu.pl)
  • In conclusion, our data indicate that SSD is a major contributing factor of late graft loss following ATG induction and that anti-Neu5Gc antibodies increase over time in SSD(+) patients. (nih.gov)
  • sera from children were tested for antibodies to viral capsid antigens of epstein-barr virus. (liverpool.ac.uk)
  • Following the use of antibodies for induction therapy, patients are typically given maintenance therapy with tacrolimus, mycophenolate and commonly, steroids. (clinnephrologyjournal.com)
  • Studies characterising the immune response in patients with COVID-19 show that the correlates of protection in infected individuals are T-cell responses against the SARSCoV-2 spike protein and neutralising titres of immunoglobin G and immunoglobin A antibodies. (bvsalud.org)
  • In a single arm, phase II study, 62% (13/21) of AA patients responded when treated with rATG/cyclosporine up-front. (haematologica.org)
  • 15 Similarly, a prospective study in China enrolled AA patients into four different ATG-based treatment regimens, including hATG and rATG in combination with cyclosporine and growth factors. (haematologica.org)
  • 2 , 3 When used as a first-line treatment for severe AA, 60-70% of patients have a hematologic response. (haematologica.org)
  • positive serum tests for infectious mononucleosis (im) unaccompanied by the clinical syndrome or blood changes characteristic of the disease were detected in 39/177 (22%) mentally subnormal patients investigated with three different commercially available im slide tests. (liverpool.ac.uk)
  • Elderly patients are known to be at higher risk for malignancies and infectious complications given the reduction of immune surveillance that occurs with age. (atcmeetingabstracts.com)
  • Moreover, SSD(+) patients exhibited significantly elevated titers of anti-ATG (P = 0.043) and anti-Neu5Gc (P = 0.007) IgGs in late post-graft samples compared with SSD(-) recipients. (nih.gov)
  • Thus, under general anesthesia by nasotracheal intubation, the patient underwent the surgical procedure for maxilla reconstruction using calvarial bone graft . (1library.co)
  • Also, there was an association between absence of radiographic signs of osseointegration of the structural graft and failure in this series of patients with large bone defects. (bvsalud.org)
  • based on the MDRD equation), acute rejection, and graft and patient survival. (atcmeetingabstracts.com)
  • Kaplan-Meier event curves were constructed for patient and graft survival. (atcmeetingabstracts.com)
  • Kaplan-Meier survival analyses showed no difference between the two induction agents for graft or patient survival. (atcmeetingabstracts.com)
  • Induction with rATG or IL-RA in elderly transplant recipients showed similar efficacy in terms of preserving patient and graft survival. (atcmeetingabstracts.com)
  • A successful kidney transplant offers enhanced quality of life and increased life expectancy and is more effective (medically and economically) than long-term dialysis therapy for patients with chronic or end-stage kidney disease. (medscape.com)
  • Although antilymphocyte serum was used in the treatment of chronic lymphocytic leukemia and in T-cell and B-cell lymphomas, resulting in temporary decreases in lymphocyte counts or lymph node size, newer humoral immunotherapeutic modalities have been developed. (msdmanuals.com)
  • Also indicated in Rh0(D)-positive, non-splenectomized adult patients with chronic immune thrombocytopenic purpura (ITP) to raise platelet counts. (drugbank.com)
  • However, early diagnosis of the case, the administration of appropriate antibiotic, stereotactic aspiration alone or craniotomy has a successful outcomes even in a post renal transplant patient treated with anti tuberculosis treatment. (biomedcentral.com)
  • Patients without a matched family donor normally are treated with immune suppressive therapy (IST). (ucsf.edu)
  • Nocardiosis is an opportunistic infection in a patient with underlying immune suppression and organ transplant. (biomedcentral.com)
  • The multipotent stem cells in the bone marrow reconstitute all three blood cell lines, giving the patient a new immune system, red blood cells, and platelets. (webdicine.com)
  • 10-33% of all patients develop the rare disease paroxysmal nocturnal hemoglobinuria (PNH, anemia with thrombopenia and/or thrombosis), which has been explained as an escape mechanism by the bone marrow against destruction by the immune system. (webdicine.com)
  • Enteral feeding via a percutaneous gastrostomy tube is commonly used for patients with cystic fibrosis and should be continued during the postoperative period. (clinicalgate.com)
  • A complete cardiac workup, including angiography, is not necessary in every transplant candidate, but patients with a significant history, symptoms, diabetes mellitus, or hypertensive kidney disease should undergo a thorough evaluation to rule out significant coronary artery disease (CAD). (medscape.com)
  • TLI has enabled some transplant patients to quit using other immunosuppressive agents altogether. (nanomedicine.com)
  • Match unrelated donor (URD) bone marrow transplant (BMT) is used as a secondary treatment in patients who did not get better with IST, had their disease come back, or a new worse disease replaced it (like leukemia). (ucsf.edu)
  • For example, antilymphocyte serum, or OKT3, are some of these drugs that can increase the risk of post-transplant lymphoproliferative disorder, or PTLDs, which is one of the most critical possible consequences of organ transplants. (tebmedtourism.com)
  • [ 2 ] Nevertheless, extended survival was seen in a few patients and included a 3-year-old girl who received a multivisceral transplant (stomach, duodenum, pancreas, small bowel, colon and liver). (medscape.com)
  • [ 5 ] In a series of 6 intestine transplant recipients treated with CsA, the mean survival rate was 25.7 months -- 2 patients surviving for 5.5 and 5 years. (medscape.com)
  • Increase urinary biomarkers of kidney injury in patients after allogenic hematopoietic stem cell transplant reflect kidney damage even in normal kidney function. (edu.pl)
  • Kidney transplant recipients have higher malignancy prevalence than hemodialyzed patients. (edu.pl)
  • This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment. (nih.gov)
  • Rapid kidney allograft failure in patients with polyoma virus nephritis with prior treatment with antilymphocyte agents. (mcw.edu)
  • While hATG has been the primary treatment used for severe AA, patients with relapsing or refractory AA often receive rATG after a first course of hATG. (haematologica.org)
  • The study will also address patient-reported outcomes and gonadal function in each arm and explore critical biological correlates including assessing germline genetic mutations associated with pediatric SAA that may lead to a predisposition to the disease and the risk of development of clonal hematopoiesis following IST vs BMT in pediatric and young adult SAA. (ucsf.edu)
  • A chief complain of chest pain, coughing and evening rise of fever was revealed by the patient prior to hospital re-admission. (biomedcentral.com)
  • In UD CYA group one patient had fever and none had glue embolism. (plk-signaling.com)
  • Regular full blood counts are required to determine whether the patient is still in a state of remission. (webdicine.com)
  • Nearly, after 2 month (January 2015) the patient was admitted in TUTH under Nephrology unit with a chief complain of altered sensorium, hyponatremia and twitching of face. (biomedcentral.com)
  • To avoid the increased risk of desensitization and ABO-incompatible transplants, patients with incompatible living donors may chose to participate in kidney paired exchange (KPD) or donor swap programs. (medscape.com)
  • 25 sera from healthy donors were titrated as controls. (liverpool.ac.uk)
  • An extensive experience accrued to date in transplanting CF patients has generally allayed these concerns, demonstrating arate of bacterial pulmonary infections similar to that encountered in other patient populations 5 . (ersjournals.com)
  • Tacrolimus level was assessed as 6.5 micro gm/dl with normal PBS, RFTs, and LFTs and the patient was discharged after 9 days. (biomedcentral.com)
  • Conclusion: despite partial V2 agonist effects, clinically significant hyponatremia did not occur in our cohort of cirrhotic patients with variceal bleeding or hepatorenal syndrome. (plk-signaling.com)
  • Methods: Thirty consecutive patients with bleeding GV between July, 2010 and June, 2014 were treated with CYA injection, 15 with UD CYA method and 15 with undiluted CYA (U CYA group). (plk-signaling.com)
  • Methods: One hundred thirteen consecutive patients with GV treated by B-RTO from December 1994 to March 2014 were retrospectively analyzed in this study. (plk-signaling.com)
  • Methods A total of 40 patients (44 hips) operated from 1995 to 2015 were retrospectively analyzed. (bvsalud.org)
  • Approximately 20% of all renal transplants performed in the US in 2014 occurred in elderly patients. (atcmeetingabstracts.com)
  • the patient had a dramatic recovery after corticosteroid therapy. (liverpool.ac.uk)
  • Clinicians must stress the need for patient compliance with therapy. (medscape.com)
  • This procedure will bring many benefits and convenience for kidney patients compared to other treatments, i.e. dialysis. (tebmedtourism.com)
  • Engraftment speed after RIST was fast and seven of 22 patients did not require platelet transfusion. (psu.edu)
  • Antilymphocyte immunoglobulin from horse serum is classified in L04AA03. (whocc.no)
  • The data collection sought sociodemographic, clinical and immunological information of the patients at the moment diagnosis for HIV infection. (bvsalud.org)
  • production of interferon or interferon-like susbstances in eb3 cultures after inoculation with human serum containing australia antigen]. (liverpool.ac.uk)