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  • responses
  • The ability of the two candidate vaccines to generate antigen-specific cellular and humoral responses, respectively, was studied. (diva-portal.org)
  • Responses were seen in smallpox-vaccinated as well as vaccinia-naive patients, as defined by anti-vaccinia antibody responses demonstrated by ELISA assay. (ox.ac.uk)
  • Ongoing analyses will reveal associations between the levels of different leukocyte populations with T cell responses to tumour-associated antigens. (biomedcentral.com)
  • In the case of BC patients under neoadjuvant therapy, the identification of predictive markers of clinical response using whole blood or PBMCs is desirable because this would help the adjustment of the chemotherapy regimes in trying to achieve pathological complete responses (pCR) in all patients treated. (beds.ac.uk)
  • Although experimental evidence suggests that primary chemotherapy with Doxorubicin induces ICD that favors anti-tumor responses and changes in the contexture of the tumor, the effect of Doxorubicin on T and APC compartments in patients under primary chemotherapy is yet to be demonstrated. (beds.ac.uk)
  • We compared the effect of intradermal versus intranodal administration of a DC-vaccine on induction of immunological responses in melanoma patients and examined if concomitant administration of interleukin-2 (IL-2) increases the efficacy of the DC-vaccine. (aacrjournals.org)
  • Within all GBM patients receiving post-vaccine chemotherapy, however, CD8 + TRECs predicted significantly longer chemotherapeutic responses, revealing a strong link between the predominant T-cell effectors in GBM and tumor chemosensitivity. (aacrjournals.org)
  • Antigen-Specific Antitumor Responses Induced by OX40 Agonist Are Enhanced by the IDO Inhibitor Indoximod. (nih.gov)
  • 90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma. (nih.gov)
  • The research will focus on expanding knowledge of the biological pathways involved in suppressing patients' immune responses to tumors prior to and during immune-based therapeutic exposure. (benfranklin.org)
  • A recurring scenario is that therapeutic maneuvers initially led to measurable antitumor immune responses in cancer patients but ultimately failed to improve patient outcomes. (hindawi.com)
  • gp100
  • HLA-A2.1+ melanoma patients scheduled for regional lymph node-dissection were vaccinated 4 times biweekly via intradermal or intranodal injection with 12-17x10 6 mature DC loaded with tyrosinase and gp100 peptides together with keyhole limpet hemocyanin (KLH). (aacrjournals.org)
  • By enumerating with epitope/HLA tetrameric complexes (tHLA) vaccine-elicited T cell precursor frequencies ( Tc-pf ) in melanoma patients exposed to the modified gp100 epitope gp100:209-217 (g209-2M) we observed in most patients that the Tc-pf increased with number of immunizations. (jimmunol.org)
  • vitro
  • In this prospective study, we designed an in vitro system to monitor various immunological readouts in PBMCs obtained from a total of 17 breast cancer patients before, and after neoadjuvant anti-tumor therapy with A/C. (beds.ac.uk)
  • glioblastoma
  • Cell lines were successfully established for nearly half of patients, with the highest success rates in melanoma, renal cell, sarcoma, and glioblastoma. (springer.com)
  • The median survival for patients with recurrent glioblastoma multiforme in this study ( n = 8) was 133 weeks. (aacrjournals.org)
  • Survival and progression times were analyzed retrospectively in 25 vaccinated (13 with and 12 without subsequent chemotherapy) and 13 nonvaccinated de novo glioblastoma (GBM) patients receiving chemotherapy. (aacrjournals.org)
  • malignant
  • The overwhelming majority of patients with malignant glioma, composed of GBM and anaplastic astrocytoma (AA), experience increasingly rapid tumor recurrence after surgical resection or other treatment and eventually succumb to such events. (aacrjournals.org)
  • Malignant brain tumors are among the gravest forms of cancer. (aacrjournals.org)
  • peripheral blood
  • Similarly, even though CLL therapy by Chlorambucil results in significant reduction in peripheral blood B-cell clonality, CLL patient samples remain distinct from equivalent samples from healthy individuals. (docplayer.net)
  • diagnosis
  • Nearly five of every six patients with newly diagnosed FL will have advanced disease, either due to a long asymptomatic phase prior to diagnosis or early dissemination. (frontiersin.org)
  • cellular
  • Processes that encourage the loss of cellular control may be tumor initiators (directly causing mutations) or promoters (facilitating mutations). (biomedcentral.com)
  • residual
  • Accordingly, the net result of immunoediting after therapy could be either cure (complete tumor eradication), or prolonged remission (persistence of dormant residual tumors), or relapse (tumor escape and progression). (hindawi.com)
  • outcome
  • The host-tumor interactions proceed through the three immunoediting phases either independently or in sequence, and the composite result of the process determines the outcome of tumor rejection, dormancy, or progression. (hindawi.com)
  • Retrospective
  • It was created from a retrospective database analysis of patients not treated with current chemoimmunotherapy, was missing significant amounts of data (ESR, β2M, and performance status), and had an endpoint of OS. (frontiersin.org)