Patients also receive amifostine. Medical search. Frequent questions

Dr. Buentzel concluded that amifostine could reduce the typical acute chemotherapy-related toxicities and should be able to reduce radiation-induced acute toxicities but must be administered within an interval of no more than 60 minutes following the end of radiotherapy. (cancernetwork.com)
These were the first data to show a reduction of mucositis from amifostine given prior to chemotherapy. (cancernetwork.com)
Amifostine is used protect the kidneys from harmful effects of the chemotherapy drug cisplatin in patients that receive this medication for the treatment of ovarian cancer. (medlineplus.gov)
When amifostine is used to protect the kidneys against the harmful effects of cisplatin, it is usually given over 15 minutes starting 30 minutes before you receive your chemotherapy treatment. (medlineplus.gov)
Amifostine is also sometimes used to prevent and decrease side effects associated with certain chemotherapy medications or radiation treatment and in the treatment of some types of blood cell diseases. (medlineplus.gov)
Amifostine (ethiofos) is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. (wikipedia.org)
Amifostine (WR-2721), a phosphoaminothioate, is capable of providing marked protection from both radiation- and selected chemotherapy-induced damage for a wide variety of tissues in both rodents and humans (1, 2, 3, 4, 5, 6) . (aacrjournals.org)
If a patient has locally advanced cancer, combined chemotherapy and radiation are typically offered if the patient can tolerate both. (beaumont.org)
However, radiation therapy alone can be used to treat localized cancer in patients who cannot tolerate surgery or chemotherapy. (vacancer.com)
Radiation therapy alone can also be used to decrease the symptoms from esophageal cancer in patients with more advanced disease who are medically unable to receive surgery or chemotherapy or for patients who have a recurrence after surgery. (vacancer.com)
However, patients with locally recurrent cancer usually receive simultaneous chemotherapy. (vacancer.com)
Newer chemotherapy drugs that are effective for patients with advanced esophageal cancer are being used in combination with radiation therapy. (vacancer.com)
In the average-risk medulloblastoma patients, this trial tests whether the addition of sodium thiosulfate (STS) to standard of care chemotherapy and radiation therapy reduces hearing loss. (ucsf.edu)
The overall goals of this study are to see if giving STS along with standard treatment (radiation therapy and chemotherapy) will reduce hearing loss in medulloblastoma patients and to compare the overall outcome of patients with medulloblastoma treated with STS to patients treated without STS on a previous study in order to make sure that survival and recurrence of tumor is not worsened. (ucsf.edu)
To evaluate the efficacy of sodium thiosulfate (STS) infusion administered during cisplatin-containing chemotherapy cycles (compared to a historical cohort selected from ACNS0331 which received chemotherapy without STS) in reducing hearing loss in children with newly-diagnosed average-risk medulloblastoma . (ucsf.edu)
For many patients, the medical team will surgically install a central venous line (catheter) in a vein in the chest (subcutaneous port) or arm before chemotherapy starts. (curesearch.org)
80. Pre-chemotherapy, the patient/client should be referred to a dentist for consideration of selective teeth extraction (for [78], Several types of medication seem to be responsible for the appearance of TEN-SJS. (jonnevandermeijden.nl)
Throughout chemotherapy, the dentist must be aware of the degree of immunosuppression of the patient. (jonnevandermeijden.nl)
Confirm with patients who have received chemotherapy that their blood tests are normal prior to providing invasive dental treatment. (jonnevandermeijden.nl)
Induction chemotherapy is typically given to patients with stage III-IVB disease in order to shrink a primary tumor to reduce its bulkiness in preparation for future surgery or radiation therapy. (medscape.com)
What Should be the Optimal Timing for Amifostine Administration Relative to Radiation and Chemotherapy. (tobaccofreenurses.org)

Your doctor will tell you to stop taking your blood pressure medicine 24 hours before you receive amifostine injection. (medlineplus.gov)
If you are taking medicine for high blood pressure, you should stop taking it 24 hours before you receive amifostine. (stjude.org)

At 5 years after treatment, the survival rate in the amifostine group is a little bit better than in the control group, and we have no sign of tumor protection. (cancernetwork.com)
All patients had definitive radiochemotherapy with a conventional fractionation, linear accelerator using single doses of 2 Gy to a whole dose of 60 Gy to the primary tumor and cervical nodes, with a boost to 70 Gy for sites of tumor. (cancernetwork.com)
Subgroup analysis stratified according to tumor volume showed that patients with tumors smaller than 20 cm³ had better response with the intensified regimen, especially in overall survival (median 22 months vs 15 months) and in time to progression (median 17 months vs 10 months). (cancernetwork.com)
Additional data have shown that amifostine-mediated tumor protection, in any clinical scenario, is unlikely. (wikipedia.org)
Differences in gender, tumor stage, amifostine dose, age, number of days after neck dissection, and smoking history (pack years) exposure were not significant between the three groups, although there was a difference between groups in the primary subsite (P = 0.006). (lvhn.org)
Currently chemotherapeutic agents are the most common clinical treatment strategies employed to suppress tumor growth, but TNBC patient responses differ from case to case. (encyclopedia.pub)
In addition, patients usually suffer from side effects, such as fatigue, emesis, hair loss, and anemia, due to a lack of an effective tumor targeting method. (encyclopedia.pub)
This challenge can be partially solved by applying patient-derived xenograft (PDX) models in the in vivo evaluation of the anti-tumor efficacy of new medicines. (encyclopedia.pub)
Malnutrition is a frequent outcome in head and neck cancer patients, not only by the tumor itself, but also as a result of the treatment which can commonly cause side effects such as dysgeusia, dysphagia, xerostomia and mucositis(7,8). (rb.org.br)

To assess the role of the polyamine transport system in radioprotection by amifostine derivatives, human DU-145 prostate cancer cells were transfected with a cDNA that encodes antizyme (OAZ), a polyamine-inducible protein that suppresses polyamine transport under control of a minimal heat shock promoter. (aacrjournals.org)

The time interval between amifostine administration and the end of daily irradiation was less than 60 minutes, and no cytoprotectant was given on days of radiotherapy alone. (cancernetwork.com)
The first 45 patients in this series received carboplatin (70 mg/m²) on days 1 to 5 and 29 to 33 of radiotherapy. (cancernetwork.com)
The next 31 patients received carboplatin at the same dose on days 1 to 5, 15 to 19, 29 to 33, and 43 to 47 of radiotherapy. (cancernetwork.com)
Amifostine is also indicated to reduce the incidence of xerostomia in patients undergoing radiotherapy for head and neck cancer. (wikipedia.org)
OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. (knowcancer.com)
However, the destructive effects of radiotherapy on native bone preclude the use of nonvascularized bone grafts in head and neck cancer patients. (bvsalud.org)
Could Amifostine Prevent Experimental Radiotherapy-Induced Acute Pericarditis? (waocp.org)
The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million received radiotherapy. (xenomica.eu)
REQUITE aims to develop validated clinical models and incorporate biomarkers to identify before treatment cancer patients at risk of side-effects and use the models to design interventional trials aimed at reducing side-effects and improving QoL in cancer survivors who underwent radiotherapy. (xenomica.eu)
The present study was aimed at analyzing the impact of enteral nutrition on the maintenance of body weight and on the necessity of replanning and/or interruption of treatment of head and neck cancer patients undergoing intensity-modulated radiotherapy (IMRT). (rb.org.br)
5% was observed in 58 patients (70%), with a higher prevalence in the group of patients who had not received pre-radiotherapy enteral nutrition. (rb.org.br)

Another 14 patients received the same regimen plus amifostine 500 mg given prior to carboplatin as a short infusion over approximately 10 minutes. (cancernetwork.com)
Mesna alone and mesna plus amifostine prevented cellular glutathione depletion. (uaeu.ac.ae)

Determine the toxicity and response to cisplatin, paclitaxel and radiation therapy in these patients. (knowcancer.com)
Purpose: To test whether intrarectal amifostine limits symptoms of radiation proctitis, measured by using the Radiation Therapy Oncology Group (RTOG) gastrointestinal (GI) toxicity score and the Expanded Prostate Cancer Index Composite (EPIC) score. (johnshopkins.edu)
Methods and Materials: Patients with localized prostate cancer received amifostine as a rectal suspension 30-45 minutes before daily three-dimensional conformal radiation therapy. (johnshopkins.edu)
Seven weeks after the start of radiation therapy, the incidence of RTOG Grade 2 toxicity was 33% in the 1-g group (6/18 patients) compared with 0% (0/12 patients) in the 2-g group and trended toward statistical significance (p = 0.06). (johnshopkins.edu)
However, since esophageal cancer is not exclusively treated with radiation therapy, it is important for patients to be treated in an environment that can offer multi-modality treatment involving radiation oncologists, surgeons, gastroenterologists, medical oncologists and nutritionists. (vacancer.com)
Treatment with radiation therapy alone results in an approximate18% survival at one year, an 8% survival at two years and less than 5% survival at 5 years in patients with localized esophageal cancer (stage I-III). (vacancer.com)
Some patients who respond to radiation therapy will develop strictures or narrowing of the esophagus that will require treatment in the future. (vacancer.com)
Ethyol® is a radiation protector and the only drug that has been approved by the FDA for xerostomia (dry mouth) in patients receiving radiation therapy for cancers of the head and neck. (illinoiscancercare.com)
It is not yet known whether radiation therapy is more effective when given alone or together with cetuximab in treating patients with head and neck cancer that has been removed by surgery. (stanford.edu)
PURPOSE: This randomized phase III trial is studying radiation therapy to see how well it works compared with radiation therapy given together with cetuximab in treating patients who have undergone surgery for locally advanced head and neck cancer. (stanford.edu)
He has personally treated 3200 head and neck patients, and gained leading technical expertise and judgement in the formulation and delivery of radiation therapy. (mdanderson.org)

ZUHL, Germany-Amifostine (Ethyol) used as cytoprotective therapy can reduce the occurrence of xero-stomia, loss of taste, and fibrosis associated with radiochemotherapy for head and neck cancer. (cancernetwork.com)

Amifostine is an organic thiophosphate prodrug which is hydrolysed in vivo by alkaline phosphatase to the active cytoprotective thiol metabolite, WR-1065. (wikipedia.org)
Although patients did not receive a full dose of amifostine due to side effects, varying doses of amifostine had no apparent evident cytoprotective effects in three groups of cancer patients treated with primary chemoradiation. (lvhn.org)

this recipe has been used in clinical practice, particularly for patients requiring small doses (e.g., young children). (pdr.net)
Conclusions: Higher doses of amifostine produced significant improvements in acute and late bowel QoL (up to 1 year after therapy), measured using the EPIC score. (johnshopkins.edu)
Rats in groups 4 and 5 received two different doses of O. gratissimum orally by gavage at 250 mg/kg and 500 mg/kg respectively for ten consecutive days before administering CP (200 mg/kg) on the tenth day. (researchwap.com)

Determine the toxicity of amifostine in these patients. (knowcancer.com)
Amifostine was originally indicated to reduce the cumulative renal toxicity from cisplatin in non-small cell lung cancer. (wikipedia.org)
Assess the nature and degree of toxicity of this regimen in these patients. (knowcancer.com)
In spite of the clear dosimetric gain which can be translated into late toxicity reduction, patients undergoing IMRT may present important acute toxicity during or immediately after the treatment completion, which may adversely impact on nutritional status maintenance and cause interruptions of the treatment. (rb.org.br)

However, while nephroprotection was observed, the probability that amifostine could protect tumors could not be excluded. (wikipedia.org)

Patients with severe acute radiation sickness receive reverse isolation, antimicrobial and anti-inflammatory agents, and bone marrow support. (msdmanuals.com)
virtually every patient has some manifestation of acute radiation-induced injury of the GI tract in the form of abdominal cramping, tenesmus, urgency, bleeding, diarrhea, and incontinence. (medscape.com)

OBJECTIVES: I. Assess the efficacy and role of amifostine as a cytoprotection agent with concurrent chemoradiotherapy in advanced, previously irradiated or metastatic head and neck cancer. (knowcancer.com)
Saline or 6% dextrose in cm) (6.9 age in a decrease in breast can- ploidy have a metastatic evaluation and management of patients are in treating pain. (umbc.edu)
The Pediatric Oncology Group study for metastatic Ewing's sarcoma used amifostine and mesna with the alkylating agents. (uaeu.ac.ae)

Inside cells, amifostine detoxifies reactive metabolites of platinum and alkylating agents, as well as scavenges free radicals. (wikipedia.org)
Amifostine metabolites WR-1065 and the disulfide WR-33278are thiol-containing polyamine analogues with potent radio- and chemoprotective properties. (aacrjournals.org)

Some studies suggest that amifostine exerts differential cytoprotection in normal versus neoplastic tissues, but this finding remains controversial. (aacrjournals.org)
Selective exclusion of amifostine derivatives by the polyamine transporter could account for differential radio- or chemoprotection in normal versus neoplastic tissues in specific situations. (aacrjournals.org)
Surrounding tissues receive minimal radiation. (beaumont.org)

Patients receive paclitaxel by continuous infusion on days 0-3. (knowcancer.com)
Amifostine administration during mesna infusion caused transient increase in mesna levels. (uaeu.ac.ae)

Amifostine is a prodrug that is dephosphorylated by alkaline phosphatase to its active component (12) . (aacrjournals.org)

per the labeled instructions to patients, the medication is formulated to release slowly. (pdr.net)
This medication bears a heightened risk of causing significant patient harm when it is used in error. (unboundmedicine.com)

Amifostine is also used to decrease dryness in the mouth caused by radiation treatment after surgery for head and neck cancer. (medlineplus.gov)
When amifostine is used to reduce the severe dry mouth caused by radiation treatment, it is usually given over 3 minutes starting 15-30 minutes before your radiation treatment. (medlineplus.gov)

Serious side effects include: hypotension (found in 62% of patients), erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis, immune hypersensitivity syndrome, erythroderma, anaphylaxis, and loss of consciousness (rare). (wikipedia.org)
Contraindications to receiving amifostine include hypersensitivity to amifostine and aminothiol compounds like WR-1065. (wikipedia.org)

Heart failure is not the same as heart attack, and may start off with mild or no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after light physical activity such as walking. (mydr.com.au)
Determining the underlying etiology, education/reassuring the patient/family and treating the symptoms should occur simultaneously. (chestervetclinic.com)
The symptoms of most patients resolve within weeks of RT cessation. (medscape.com)
Patients may present with symptoms within months or even decades after the injuring RT. (medscape.com)
A patient who worked with x-rays had developed abdominal pain and diarrhea, symptoms that resolved with the use of a lead shield. (medscape.com)
She is recognized for her scholarship promoting nursing involvement in tobacco control and in oncology nursing research focused on quality of life and symptoms of patients with lung cancer. (tobaccofreenurses.org)

The pilot trial was a controlled phase II study involving 14 patients randomized to receive standard radiochemotherapy, with radiation administered in 2-Gy fractions to a total dose of 60 Gy plus carboplatin (Paraplatin) 70 mg/m² as a radiosensitizer weeks 1 and 5. (cancernetwork.com)
This study was followed by a controlled, phase II dose-intensification study to evaluate the role of intensified carboplatin dosage with amifostine protection and concomitant radiochemotherapy in locally advanced pharyngeal cancer. (cancernetwork.com)
OUTLINE: Patients receive paclitaxel IV over 3 hours, then amifostine IV over 10 minutes, followed fifteen minutes later by carboplatin IV over 30-60 minutes on day 1. (knowcancer.com)

Patients receive no treatment on days 6-13. (knowcancer.com)
You should not breast-feed during your treatment with amifostine. (medlineplus.gov)
Advances are continually being made in the treatment of head and neck cancer, and patients at Beaumont may be eligible for clinical trials, either approved within the hospital or sponsored by national organizations dedicated to advancing cancer treatment. (beaumont.org)
The nonparametric Cuzick's test for histologic parameters with varied amifostine treatment showed no significance among the three groups. (lvhn.org)
The progress that has been made in the treatment of esophageal cancer has resulted from improved development of adjuvant treatments and doctor and patient participation in clinical studies. (vacancer.com)
We also conducted analogous measurements on two patients who received mesna alone and a volunteer's blood following in vitro treatment. (uaeu.ac.ae)
Treatment of eczema herpeticum † [off-label] in patients with a history of atopic dermatitis. (drugs.com)
Treatment of HSV keratitis † [off-label] in HIV-infected patients. (drugs.com)
Treatment of herpes zoster ophthalmicus † in HIV-infected patients. (drugs.com)
Treatment of dermatomal herpes zoster in immunocompromised patients † including transplant recipients and HIV-infected patients. (drugs.com)
The Foundation is able to help patients receiving treatment for indications for which we currently have an open fund. (healthwellfoundation.org)
The patient must receive treatment in the United States. (healthwellfoundation.org)
4. You are receiving treatment in the United States. (healthwellfoundation.org)
If you are receiving treatment in the U.S. and have met the eligibility criteria as listed, you are ready to apply! (healthwellfoundation.org)
Anticipate the need to change treatment options if agitation develops, particularly in cases where patient, family and staff safety may become threatened. (chestervetclinic.com)
Treatment of these patients is extremely challenging. (medscape.com)
Infants and toddlers with ALL or neuroblastoma who receive anthracyclines have more frequent echocardiographic abnormalities than older children who receive the same treatment. (medscape.com)
Only five patients (6%) had their treatment interrupted for a period ranging from 4 to 18 days, and in 19 cases (23%) required replanning. (rb.org.br)

It is also used for patients who have rectal bleeding or abnormal bowel movements to identify the causes of these problems. (oncolink.org)

2. Patients with carcinoma of the head and neck in whom the submandibular glands are enclosed completely in the clinical target volume. (who.int)
Dr. William Morrison is a Professor of Radiation Oncology at M.D. Anderson Cancer Center, with 31 years of clinical experience treating patients with head and neck cancer. (mdanderson.org)

The purpose of this study was to assess the effects of amifostine on submandibular gland histology in patients receiving chemoradiation therapy. (lvhn.org)
To assess the difference in the maximum salivary uptake (U max) between patients whose submandibular glands were spared compared to those in whom they were not spared at 6 months post-radiation.Timepoint: To assess the difference in the maximum salivary uptake (U max) between patients whose submandibular glands were spared compared to those in whom they were not spared at 6 months post-radiation. (who.int)

Your doctor will give you medicine to reduce nausea while you receive amifostine. (stjude.org)

Evaluate response (confirmed and unconfirmed partial response and complete response) rate to this regimen in this patient population. (knowcancer.com)

At Beaumont, interstitial brachytherapy is used to treat recurrent neck disease in patients previously treated with external beam radiation. (beaumont.org)

Amifostine may cause side effects. (medlineplus.gov)
Side effects not only cause patients discomfort, but also may prevent the optimal delivery of therapy at its planned dose and schedule. (vacancer.com)
1. Itraconazole is rarely used, but serious side effects can occur in patients with cardiovascular problems, especially those who receive cisapride, pimozide, and guanidine therapy. (jonnevandermeijden.nl)
This led to the realisation that he could often treat his patients with nutritional therapies, thus avoiding pharmaceutical drugs and their inevitable side effects. (thecancerrevolution.co.uk)

Monitor for development of hemorrhagic cystitis in patients receiving ifosfamide. (drugguide.com)

If you become pregnant while receiving amifostine, call your doctor. (medlineplus.gov)

We conducted a retrospective submandibular gland histologic slide review of HNSCC patients receiving chemoradiation for head and neck squamous cell carcinoma with three different levels of amifostine exposure. (lvhn.org)
Patients with head and neck cancer receiving submandibular gland plus parotid sparing volumetric modulated arc therapy. (who.int)

The trial enrolled 76 consecutive patients (mean age 55 years) with unresectable locally advanced squamous-cell carcinoma without distant metastases. (cancernetwork.com)

Patients internally contaminated with certain specific radionuclides may receive uptake inhibitors or chelating agents. (msdmanuals.com)
Use with extreme caution in patients receiving MAO inhibitors within 14 days prior (may result in unpredictable, severe reactions-↓ initial dose of morphine to 25% of usual dose). (unboundmedicine.com)

In diabetic or impaired renal patients, risk of hyperkalaemia, worsening of renal function and cardiovascular morbidity and mortality increase. (azurewebsites.net)
simultaneous application of aliskiren or aliskirensoderzhaschimi drugs in patients with diabetes mellitus and / or impaired renal function (glomerular filtration rate of less than 60 ml / min / 1.73m2). (pharmru.com)

Amifostine is used therapeutically to reduce the incidence of neutropenia-related fever and infection induced by DNA-binding chemotherapeutic agents including alkylating agents (e.g. cyclophosphamide) and platinum-containing agents (e.g. cisplatin). (wikipedia.org)
reduce the risk of death or need for hospitalisations due to heart failure in patients with chronic heart failure. (mydr.com.au)
4. use the prospectively validated models and biomarkers to design interventional trial protocols aiming to reduce sideeffects and improve QoL in high-risk patients. (xenomica.eu)

Febrile neutropenic patients with locally advanced the vinca alkaloids, discussed earlier, in experimental systems tubulin from binding and modulation of the british thyroid association task force on prac- match or degeneration of diarrhea, often with a low dosage (11 26 mg 10.5 200 mg orally three times daily, or diphenoxylate with atropine (initial complex is transected distal to the pulmonary artery pressure. (umbc.edu)

To evaluate household material hardship as a social determinant of neurocognitive, quality of life, and psychosocial outcomes in patients with average-risk and low risk medulloblastoma. (ucsf.edu)

To evaluate full scale intelligence neurocognitive outcomes and trajectories of patients with average-risk medulloblastoma treated with STS compared to the control cohort from ACNS0331. (ucsf.edu)
To evaluate quality of life and psychosocial outcomes and trajectories of patients with average-risk medulloblastoma treated with STS compared to published norms. (ucsf.edu)
To evaluate the trajectory of hearing loss in medulloblastoma patients treated with STS. (ucsf.edu)
To evaluate attention, processing speed, memory, and executive function neurocognitive outcomes and trajectories, as well as hearing-related quality of life outcomes and trajectories, of patients with average-risk medulloblastoma treated with STS. (ucsf.edu)

Only 30 percent of patients experience dry mouth with IMRT, compared to 84 percent treated with conventional external beam radiation. (beaumont.org)
Cases of patients submitted to IMRT in the period from January 2005 to October 2008 were retrospectively reviewed, and 83 of them were included in the study. (rb.org.br)

In situations where a patient is not able to complete an assessment by self reporting, then the health professional and/or the caregiver may act as a surrogate. (chestervetclinic.com)

Khouri S, Kotliroff A, Lishner M, Amital H. Imatinib-induced agranulocytosis in a patient with chronic myelogenous leukemia in remission. (jonnevandermeijden.nl)

Amifostine is believed to radioprotect normal tissue via Warburg-type effects. (wikipedia.org)
In addition to preventing cytotoxicity, amifostine derivatives display anticarcinogenic (7, 8) and antimutagenic (9) properties in rodent model systems as well as hematopoiesis-promoting effects (10, 11) . (aacrjournals.org)
The development of improved dosimetry techniques, as well as patient selection and positioning during delivery of RT, were crucial to decrease the harmful effects of radiation on the intestines. (medscape.com)
Mixed agonist/antagonist analgesics , including nalbuphine or butorphanol and partial agonist analgesics , including buprenorphine , may ↓ morphine's analgesic effects and/or precipitate opioid withdrawal in physically dependent patients. (unboundmedicine.com)

Benzodiazepines may paradoxically excite some patients and should be avoided unless the source of delirium is alcohol or sedative drug withdrawal, or when severe agitation is not controlled by the neuroleptic. (chestervetclinic.com)
Severe pain (the 20 mg/mL oral solution concentration should only be used in opioid-tolerant patients). (unboundmedicine.com)

Amifostine IV is administered over 5 minutes on days 1-5. (knowcancer.com)
Amifostine is a liquid given by the vein (IV) for 5-15 minutes. (stjude.org)
If seizure occurs while receiving magnesium, an additional bolus of 2-4 g may be administered over ≥5 minutes. (unboundmedicine.com)

To determine the fate of combined drug thiols, we measured thiol levels in plasma, red blood cells (RBC), and peripheral blood mononuclear cells (PBMC) of four patients. (uaeu.ac.ae)

In the low-risk medulloblastoma patients, the study tests whether a less intense therapy (reduced radiation) can provide the same benefits as the more intense therapy. (ucsf.edu)

Rats in group 1 received only normal saline orally for gavage for ten consecutive days. (researchwap.com)
Rats in group (8) received combination of V. amygdalina and O. gratissimum at a dose of 250 mg/kg each for ten consecutive before administering CP (200 mg/kg) on the tenth day. (researchwap.com)
Excluding the control group, all rats received a human-equivalent dose of radiation. (bvsalud.org)
First study, patients with fulminant present, though the between-group differ- particle whose membrane carries supranormal amounts of a proton-pump inhibitor b. (umbc.edu)
Various useful treatments, utilizing therapies (physiotherapy), surgery and medications have recognized neurological disorders and changes in the patient group. (hilarispublisher.com)
In 1930, researchers reported the development of factitial proctitis in a group of patients who received pelvic radiation to treat malignant disease. (medscape.com)

Amifostine is in a class of medications called cytoprotectants. (medlineplus.gov)
tell your doctor and pharmacist if you are allergic to amifostine, any other medications, or any of the ingredients in amifostine injection. (medlineplus.gov)
Many other medications may also interact with amifostine, so be sure to tell your doctor about all the medications you are taking. (medlineplus.gov)

The staff will check calcium and magnesium levels in the blood throughout the day and for up to one (1) week after you receive amifostine. (stjude.org)
Monitor newborn for hypotension, hyporeflexia, and respiratory depression if mother has received magnesium sulfate. (unboundmedicine.com)
Accidental overdose of IV magnesium has resulted in serious patient harm and death. (unboundmedicine.com)

These data demonstrate that negative regulation of the polyamine transporter, mediated by polyamines or antizyme, suppresses the uptake and radioprotective activity of amifostine derivatives. (aacrjournals.org)

The effect of amifostine on submandibular gland histology after radiat" by Jacqueline C Junn, James J Sciubba et al. (lvhn.org)
The effect of amifostine on submandibular gland histology after radiation. (lvhn.org)

Diseases5

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Health Care2

Chemotherapy21

Hours before you receive amifostine2

Tumor9

Radioprotection by amifostine1

Radiotherapy11

Plus amifostine2

Radiation therapy11

Ethyol1

Cytoprotective2

Doses3

Toxicity4

Tumors1

Acute2

Metastatic3

Metabolites2

Tissues3

Infusion2

Prodrug1

Medication2

Mouth caused by radiation2

Hypersensitivity2

Symptoms6

Carboplatin3

Treatment18

Rectal1

Clinical2

Assess2

Nausea1

Regimen1

Recurrent1

Side effects4

Ifosfamide1

Pregnant1

Neck2

Squamous1

Inhibitors2

Renal2

Reduce3

Locally1

Outcomes in Patients1

Evaluate4

IMRT2

Situations1

Chronic myelogen1

Effects4

Severe2

Minutes3

Determine1

THERAPY1

Group6

Medications3

Magnesium3

Uptake1

Submandibular2