Patients allogeneic stem cell trans. Medical search. Frequent questions

To date, six patients have relapsed and died, two after a second hematopoietic stem cell transplantation without T-cell depletion or administration of unmodified T-cells. (frontiersin.org)
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is applied successfully to the treatment of many hematopoietic malignancies, but remains limited by severe acute graft-versus-host-disease (aGvHD). (frontiersin.org)
Treatments may include supportive care, drug therapy, and hematopoietic stem cell transplantation. (wikipedia.org)
Some people have a history of exposure to chemotherapy (especially alkylating agents such as melphalan, cyclophosphamide, busulfan, and chlorambucil) or radiation (therapeutic or accidental), or both (e.g., at the time of stem cell transplantation for another disease). (wikipedia.org)
Abstract Introduction: Graft-versus-host disease (GVHD) is a serious complication in allogeneic transplantation. (scielo.org)
Causes of mortality in those patients were severe viral pneumonia, post-transplantation hemophagocytic syndrome and meningeal GVHD refractory to ruxolitinib. (scielo.org)
Background: In our country, transplantation centers differ in the age limit for allogeneic hematopoietic transplantation (ALOHT). (scielo.org)
Currently more than 60% of ALOHT reported to the Center for International Bone Marrow Transplantation Research (CIBMTR) are performed in patients older than 40 years. (scielo.org)
Aim: To report our experience with ALOHT in acute myelogenous leukemia (AML), analyzing patient age at transplantation in different periods and transplant results in different age groups. (scielo.org)
And my specialties are in blood cancers, and stem cell transplantation, and cell therapy. (kickingabs.com)
Pharmacokinetics The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (clustermed.info)
Prospective Clinical Trial of BUSULFEX: The prospective trial was a single-arm, open-label study in 61 patients who received BUSULFEX as part of a conditioning regimen for allogeneic hematopoietic stem cell transplantation. (clustermed.info)
For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
There is a paucity of information to guide selection of the most suitable stem cell donor in haploidentical (Haplo) hematopoietic stem cell transplantation (HSCT). (bvsalud.org)
Cytomegalovirus (CMV) reactivations are strong stimulators of immune-reconstitution (IR) in hematopoietic stem cell transplantation (HSCT) recipients. (bvsalud.org)
INTRODUCTION: In the era of JAK inhibitors, allogeneic stem cell transplantation (HSCT) remains the only curative treatment for patients with Myelofibrosis (MF). (bvsalud.org)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
The use of allogeneic hematopoietic cell transplantation (HCT) is the most potent immunotherapeutic treatment for hematologic diseases, but its practical use is impeded by acute and chronic graft-versus-host disease (GvHD). (cryostem.org)
Given the potential importance of MAIT cells in control of microbial infections and protection of epithelial surfaces, we investigated MAIT cell reconstitution in 43 children who underwent hematopoietic stem cell transplantation (HSCT) after myeloablative conditioning for the treatment of malignant hematological disease. (cryostem.org)
Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease. (unicatt.it)
Transfers are most likely to a bone marrow transplantation unit for stem cell reconstitution. (medscape.com)
Cutaneous manifestations in patients with Wiskott-Aldrich syndrome submitted to haematopoietic stem cell transplantation. (medscape.com)
In recent years, epigenetic therapy has become a treatment option for patients with higher-risk myelodysplastic syndrome (MDS) who are not considered candidates for intensive induction chemotherapy or allogeneic stem cell transplantation (SCT). (biomedcentral.com)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
11. Allogeneic hematopoietic stem cell transplantation in congenital hemoglobinopathies with myeloablative conditioning and rabbit anti-thymocyte globulin. (whocc.org.cn)
17. Busulfan plus melphalan versus high-dose melphalan as conditioning regimens in autologous stem cell transplantation for newly diagnosed multiple myeloma. (whocc.org.cn)
Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)

Thus, prophylactic transfusion of donor T-cells has been included in many protocols, despite the increased risk for acute GvHD ( Kolb, 2008 ). (frontiersin.org)
Eight patients from the first NGFR-HSV-TK-studies developed acute ( n = 6) or chronic GvHD ( n = 2), which resolved after treatment with GCV alone in seven of eight patients. (frontiersin.org)
Results: Since 2014, seventeen patients with GVHD were treated with ruxolitinib due to refractoriness to corticosteroids and immunosuppressants and a few to extracorporeal photopheresis, 8 with acute GVHD (1 pulmonary, 4 cutaneous grade IV and 3 digestive grade IV) and 9 with chronic GHVD (5 cutaneous sclerodermiform, 2 pulmonary and 1 multisystemic). (scielo.org)
It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
For this reason, we conducted a retrospective analysis in order to evaluate the impact of Haplo family donors characteristics on HSCT outcomes in patients with acute myeloid leukemia (AML) who received graft-versus-host disease prophylaxis with post-transplant cyclophosphamide (PTCy). (bvsalud.org)
Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all- trans retinoic acid (ATRA). (nature.com)
Acute myeloid leukemia (AML) is a disease with diverse genetic features of the leukemic cells and with variable outcome. (cancercentrum.se)
Patients with acute promyelocytic leukemia (APL) are treated according to a separate protocol (included in the care program) based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). (cancercentrum.se)
In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
Using proteomics, it has been shown that plasma concentration of Suppression of Tumorigenicity 2 (ST2), accurately stratified patients according to risk of non-response to acute GvHD therapy in large retrospective sets. (cryostem.org)
Patients with acute myelogenous leukemia (AML) present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
Some patients, particularly younger ones, present with acute symptoms that develop over a few days to 1-2 weeks. (medscape.com)
In fact, myocardial infarction may be the first presenting symptom of acute leukemia in an older patient. (medscape.com)
Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
Liver GvHD is measured by the bilirubin level in acute patients. (wikipedia.org)
According to WHO classification, 5 patients had MDS, 2 had MDS/MPD, and 17 had acute myeloid leukemia (AML). (biomedcentral.com)
The demethylating agent 5-azacytidine (AZA) can achieve substantial survival benefit for patients with higher-risk MDS and patients with acute myeloid leukemia (AML) who have a bone marrow blast count of 20-30% (RAEB-T according to the FAB classification) (Fenaux et al. (biomedcentral.com)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
20. Long-term control of refractory follicular lymphoma after treatment of secondary acute promyelocytic leukemia with arsenic trioxide (As₂O₃) and all-trans retinoic acid (ATRA). (whocc.org.cn)
In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)

Some people can be cured by chemotherapy followed by a stem-cell transplant from a donor. (wikipedia.org)
For low- and intermediate-risk patients, induction therapy should consist of ATRA and arsenic trioxide (ATO) without chemotherapy. (medscape.com)
ATRA plus ATO with a certain amount of chemotherapy is a possible option, but ATO is not approved for use in high-risk patients. (medscape.com)
Seventy-six percent of patients were treated with intensive chemotherapy. (scielo.org)
The median survival of patients treated with intensive chemotherapy aged less than 60 years and 60 years and above was 3.4 and 1 year, respectively. (scielo.org)
Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
Furthermore, with ATRA-ATO combinations, chemotherapy may safely be omitted in low-risk patients. (nature.com)
In the past two decades, therapy for newly diagnosed APL has evolved from an all- trans retinoic acid (ATRA)+chemotherapy backbone for all patients to the addition of arsenic trioxide (ATO) to ATRA with omission of chemotherapy in low-risk patients as a new standard of care. (nature.com)
Most patients up to the age of approximately 75 years should be considered for intensive combination chemotherapy with the aim to induce complete remission. (cancercentrum.se)
Seven patients (29%) had previously received intensive chemotherapy, and five had previous HDAC inhibitor treatment. (biomedcentral.com)
In patients, primary or acquired resistance to chemotherapy is associated with the expression of P-gp. (ashpublications.org)
14. Effectiveness of darbepoetin alfa in multiple myeloma patients receiving chemotherapy including novel agents. (whocc.org.cn)

The major component of induction therapy is all-trans retinoic acid (ATRA), which is commonly combined with other agents. (medscape.com)
In 2001, two independent groups showed that the antiepileptic drug valproic acid (VPA) also has HDAC inhibitory activity and induces differentiation of malignant myeloid cells, an ability that is enhanced by all-trans retinoic acid (ATRA) (Göttlicher et al. (biomedcentral.com)

After one rest day, allogeneic hematopoietic progenitor cells were infused. (clustermed.info)
This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Independent origins of fetal liver haematopoietic stem and progenitor cells. (u-tokyo-hemat.com)
In vitro differentiation of GS-2 iPSCs into hematopoietic stem and progenitor cells was done using Op9 feeder layers and specified media. (biomedcentral.com)

CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
This study describes the first comparative phosphoproteome analysis of growing erythroid cells (gECs), derived from human haematopoietic stem cells, exposed to lysates of infected erythrocytes (IE)/uninfected erythrocytes (UE) for 24, 48 and 72 h. (biomedcentral.com)
Moreover, in vitro cultures of erythroid cells derived from haematopoietic stem cells has demonstrated that P. vivax is able to directly inhibit erythroid cell proliferation and differentiation [ 22 ]. (biomedcentral.com)

HSCT patients are presumed immunocompetent if they are at least 24 months post-HSCT, are not receiving immunosuppressive therapy, and do not have graft- versus-host disease (GVHD). (cdc.gov)
All patients received a conditioning backbone based on treosulfan and fludarabine, with post-transplant cyclophosphamide (PTCy) and sirolimus as graft-versus-host disease (GvHD) prophylaxis. (bvsalud.org)

Thus, we studied the safety, efficacy, and feasibility of transfer of gene modified donor T-cells shortly after allo-HSCT in two clinical trials between 2002 and 2007 and here we compare the results to unmodified donor leukocyte infusion (DLI). (frontiersin.org)
The aim of these trials was to provide patients with the protection of T-cells after T-cell-depleted allo-HSCT in the matched or mismatched donor setting with an option to delete transduced T-cells, if severe aGvHD occurred within the trial period. (frontiersin.org)
Donor-T-cells were transduced with the replication-deficient retrovirus SFCMM-3, expressing HSV-TK and the truncated ΔLNGFR for selection of transduced cells. (frontiersin.org)
Donor chimerism was stabilized after transfusion of the transduced cells in all patients treated. (frontiersin.org)
In conclusion, donor-related variables significantly influence AML patient outcomes following Haplo-HSCT with PTCy. (bvsalud.org)
METHODS: We conducted a retrospective analysis on 14 patients with MF who underwent HSCT with SI from any donor source at our center between June 2016 and March 2021. (bvsalud.org)
With a median post-transplant follow-up of 25 months, 6 patients remain in CR with full-donor chimerism, 3 patients died due to NRM. (bvsalud.org)
At Cellebration, we have mastered the technology for isolating the maximum number of viable stem cells from either the autologous sources of your own body or allogeneic with the matched donor to treat various patients with Scleroderma. (cellebrationlifesciences.com)
Immune cells, meanwhile, suffer from large donor-to-donor variability, making both process characterization and development and the establishment of process control strategies difficult, particularly for autologous applications, according to Matuszczyk. (biopharminternational.com)
Process development work is often done using health donor cells, which characteristically could be very different compared to patient cells," he says. (biopharminternational.com)
[10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
All GS-2 iPSC clones displayed a normal karyotype (46XX or 46XY) and were shown to express the same RAB27A gene mutation that was present in the original somatic donor cells. (biomedcentral.com)
the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)

Patients received 16 BUSULFEX doses of 0.8 mg per kg every 6 hours as a two-hour infusion for 4 days, followed by cyclophosphamide 60 mg per kg once per day for two days (BuCy2 regimen). (clustermed.info)
All patients received 100% of their scheduled BUSULFEX regimen. (clustermed.info)

In our program, transplants with age- adjusted conditioning are performed in patients until 70 years old. (scielo.org)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
The idea to use transplants of dopa- ment of protocols that allow generation of fully functional mine-producing cells to substitute for the lost midbrain and safe midbrain dopamine neurons from stem cells. (lu.se)

Forty-eight percent of patients (29/61) were heavily pretreated, defined as having at least one of the following: prior radiation, greater than or equal to 3 prior chemotherapeutic regimens, or prior hematopoietic stem cell transplant. (clustermed.info)
Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)

Overall, in our study the use of LTV was associated with a slight improvement of B-cell and NK-cells reconstitution, with only minor impact on T-cell subsets, giving new insights on polyclonal IR for HSCT recipients in the LTV era. (bvsalud.org)

With considerable advances in therapy, including the introduction of ATRA initially as a single agent and then in combination with anthracyclines, and more recently by development of arsenic trioxide (ATO)-containing regimens, APL is now characterized by complete remission rates of 90% and cure rates of ∼ 80%, even higher among low-risk patients. (nature.com)
a Three cases that received an allogeneic transplant in the first complete remission. (jamanetwork.com)
Some patients also showed complete remission according to FISH on bone marrow mononuclear cells and CD34 + peripheral blood cells, as well as by follow-up of somatic mitochondrial DNA mutations. (biomedcentral.com)

Mesenchymal stem cells are known to have angiogenic, trans differentiation and homing properties which are useful for forming new blood vessels, differentiating into required targeted cells and creating a microenvironment for the faster secretion of immune cells. (cellebrationlifesciences.com)
Induced pluripotent stem cells (iPSCs) are another modality on the horizon with process challenges particularly associated with inducement, directed differentiation, and banking steps, comments Avi Nandi, VP and head of process development at the Center for Breakthrough Medicines. (biopharminternational.com)
In vivo differentiation to cells from all three germlines was tested using a teratoma assay. (biomedcentral.com)
Differentiation capacity into cells from all three germ layers was confirmed using the teratoma assay. (biomedcentral.com)
2017). MMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells. (sciendo.com)
Osteogenic proliferation and differentiation of canine bone marrow and adipose tissue derived mesenchymal stromal cells and the influence of hypoxia. (sciendo.com)
Abnormal proliferation, clonal expansion, aberrant differentiation, and diminished apoptosis (programmed cell death) lead to replacement of normal blood elements with malignant cells. (msdmanuals.com)
In previously reports , Plasmodium vivax was found to be able to directly inhibited erythroid cell proliferation and differentiation. (biomedcentral.com)

Malignant transformation usually occurs at the pluripotent stem cell level, although it sometimes involves a committed stem cell with more limited capacity for self-renewal. (msdmanuals.com)

Remission is when there are less than 5% blast cells in the bone marrow. (oncolink.org)

[ 1 ] The combination of arsenic trioxide with ATRA may be considered for patients who are not candidates for anthracycline-based therapy. (medscape.com)
2001 ). Stimulated by these findings, we studied the clinical effect of VPA at serum concentrations of 50-100 μg/ml in 23 patients with AML or MDS as monotherapy or in combination with (ATRA) (Kuendgen et al. (biomedcentral.com)
Interestingly, response rate was 44% for patients receiving VPA monotherapy, while none of five patients receiving VPA + ATRA from the start responded. (biomedcentral.com)

A myelodysplastic syndrome (MDS) is one of a group of cancers in which immature blood cells in the bone marrow do not mature, and as a result, do not develop into healthy blood cells. (wikipedia.org)
Some types of MDS cause an increase in the production of immature blood cells (called blasts), in the bone marrow or blood. (wikipedia.org)
The different types of MDS are identified based on the specific characteristics of the changes in the blood cells and bone marrow. (wikipedia.org)
The prognosis depends on the type of cells affected, the number of blasts in the bone marrow or blood, and the changes present in the chromosomes of the affected cells. (wikipedia.org)
This study aimed at assessing the effectiveness and safety of repeated administrations of allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) primed with tumor necrosis factor (TNF)-α and interferon-γ in an equine model of chemically-induced osteoarthritis. (biomedcentral.com)
Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
In all patients that might become considered for intensive treatment, the AML diagnosis should be based on morphologic and immunophenotypic features of bone marrow aspirates as well as on genetic characteristics of the leukemic blasts. (cancercentrum.se)
Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)
Patients with a high leukemic cell burden may present with bone pain caused by increased pressure in the bone marrow. (medscape.com)
Four additional patients achieved at least marrow remissions. (biomedcentral.com)
Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
The potential of intra-articular injection of chondrogenic-induced bone marrow stem cells to retard the progression of osteoarthritis in a sheep model. (sciendo.com)
Intra-articular injection of expanded autologous bone marrow mesenchymal cells in moderate and severe knee osteoarthritis is safe: a phase I/II study. (sciendo.com)
Adipose Tissue- and Bone Marrow-Derived Mesenchymal Stem Cells from Sheep: Culture Characteristics. (sciendo.com)
Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. (appliedstemcell.com)

Despite prophylactic treatment of the patients with immunosuppressive drugs after allo-HSCT, GvHD is still associated with non-relapse mortality (NRM) and contributes around 25% of NRM. (frontiersin.org)
There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
and phase mended strategies for preventing OIs in HSCT patients. (cdc.gov)

Methods: A retrospective analysis was performed on patients with severe GVHD refractory to corticosteroids. (scielo.org)
However, the GVHD mortality remains high in refractory patients, showing that better therapeutic strategies are needed. (scielo.org)
Discovery and availability of biomarkers suitable for screening high risk patients using early, non-invasive, blood tests specific for GvHD-therapy resistance would significantly aid in the management of patients with this disease and would allow for rational drug development and drug approval by regulatory authorities. (cryostem.org)
The white blood cells present within the transplanted tissue then attack the recipient's body's cells, which leads to GvHD. (wikipedia.org)
GvHD occurs when the donor's immune system's white blood cells reject the recipient. (wikipedia.org)
Patients with grade IV GvHD usually have a poor prognosis. (wikipedia.org)
If the GvHD is severe and requires intense immunosuppression involving steroids and additional agents to get under control, the patient may develop severe infections [12] as a result of the immunosuppression and may die of infection. (wikipedia.org)
However, a 2016 study found that the prognosis for patients with grade IV GvHD has improved in recent years. (wikipedia.org)

Here are several abstracts selected from the proceedings of this year's American Society of Hematology (ASH) Annual Meeting & Exposition, highlighting newer therapeutics in several different types of non-Hodgkin lymphomas (NHLs), including mantle cell lymphoma and marginal zone lymphoma. (ascopost.com)

Induction therapy should not be modified based on the presence of leukemia cell characteristics that have variably been considered to predict a poorer prognosis (eg, secondary chromosomal abnormalities, FLT3 mutations, CD56 expression, BCR3 PML-RARA isoform). (medscape.com)
The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
Occasionally, patients have skin rashes due to infiltration of the skin with leukemic cells (leukemia cutis). (medscape.com)
A lumbar puncture (spinal tap) to see if there are any leukemia cells in your spinal fluid. (oncolink.org)
The treatment is designed to wipe out the abnormally functioning leukemia cells. (oncolink.org)
2. Granulocytic dysplasia: an indicator of clonal evolution in patients with chronic myeloid leukemia. (whocc.org.cn)
9. Synchronous hairy cell leukemia and chronic lymphocytic leukemia: a case report with a brief review of literature. (whocc.org.cn)
12. Leukemia propagating cells in Philadelphia chromosome-positive ALL: a resistant phenotype with an adverse prognosis. (whocc.org.cn)

Dr. Tallman focuses on the molecular genetics of APL, current curative treatment strategies and approaches for patients with relapsed and refractory disease. (ashpublications.org)

Although rapid confirmation of genetic diagnosis is mandatory, patients in whom APL is suspected (on the basis of clinical presentation and peripheral blood smear results) should be immediately hospitalized and their case managed as a medical emergency. (medscape.com)
Material and Methods: Review of electronic clinical records of 114 patients with AML with a median age of 57 years (59% men). (scielo.org)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)
Clinical and synovial inflammatory signs were quicker reduced in MSC-treated groups and repeated allogeneic administration did not produce adverse reactions, but MSC-primed group showed slight and transient local inflammation after second injection. (biomedcentral.com)
The content of the care program is based on published AML data, on the clinical experience of Swedish hematologists with special interest in AML, and on the Swedish AML registry, which has been collecting data on all Swedish AML-patients since 1997. (cancercentrum.se)
Promising combinations of UniCAR NK cells and distinct targeting molecules will be identified for subsequent translation into a phase clinical study. (unimedizin-mainz.de)
Because any primary immunodeficiency disease is associated with a great complexity of medical problems, most clinical immunologists strongly think an immunologist should manage these patients. (medscape.com)
Immunoselected STRO-3+ mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis. (sciendo.com)
Cryopreserved allogeneic mesenchymal stem cells enhance wound repair in full thickness skin wound model and cattle clinical teat injuries. (sciendo.com)

I worked very closely with Dr. Bishop since he arrived, using a lot of the new therapies that are effective for this particular disease, including immunotherapy, stem cell transplant. (kickingabs.com)

Genetic characteristics of eighty-seven patients with the Wiskott-Aldrich syndrome. (medscape.com)

We observed that IL-1β-activated microvascular endothelial cells from SSc patients induce monocytes to differentiate into DC-SIGN+-, alternatively activated macrophages producing high levels of CCL18, CCL2 and CXCL8, but no IL-10. (cnrs.fr)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
due to their unlimited divisions and ability to differentiate into different cell lineages. (cellebrationlifesciences.com)

Specific Populations Pediatric Patients: In a pharmacokinetic study of BUSULFEX in 24 pediatric patients, the population pharmacokinetic (PPK) estimates of BUSULFEX for clearance (CL) and volume of distribution (V) were determined. (clustermed.info)

So we take a portion of the monoclonal antibody, which targets the cancer, and then we take a portion of an immune cell call a T-cell, and we use its receptor. (kickingabs.com)
And once it expresses that, it targets the cancer cell. (kickingabs.com)
And with that portion for that protein on the surface of the cell, that the cell gets activated, and then it kills the cancer cell. (kickingabs.com)
In patients with metastatic colorectal cancer who have mutations in BRAF V600, the addition of the BRAF inhibitor vemurafenib (Zelboraf) to cetuximab -(Erbitux) and irinotecan significantly improved progression-free survival, results of the phase II Southwest Oncology Group (SWOG) 1406 trial have. (ascopost.com)
Gastric cancer can apparently be added to the growing list of malignancies for which drugs targeting the programmed cell death protein 1 (PD‑1) receptor are effective, according to the results of the phase III ONO-4538 investigation conducted in Asia and presented at the 2017. (ascopost.com)
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. (uni-freiburg.de)
It is classified based on genetic abnormalities (changes) in the cancer cells. (oncolink.org)
Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
To address this need, we will link an ImmuNEO module to the DKTK MASTER program that will include exome and transcriptome-sequenced patients on a pan-cancer basis who receive treatment with checkpoint modulators. (unimedizin-mainz.de)
When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)

Directionally encoded color track density imaging in brain tumor patients: A potential application to neuro-oncology surgical planning. (dana-farber.org)
B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. (lookformedical.com)
If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. (lookformedical.com)
This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
Therapeutic response correlates with the mutational load of the patient tumors, suggesting that neoantigens contribute to tumor rejection. (unimedizin-mainz.de)
T cells and TCR will be obtained from blood and tumor tissue and tested for neoantigen specificity and tumor reactivity. (unimedizin-mainz.de)

Classical Hodgkin lymphoma is one of the malignancies most susceptible to treatment with monoclonal antibodies targeting the programmed cell death protein (PD-1). (ascopost.com)

Glasgow coma scale pupil score (GCS-P) and the hospital mortality in severe traumatic brain injury: analysis of 1,066 Brazilian patients. (dana-farber.org)
These findings suggest that parasite proteins are able to inhibit erythroid cell growth by down-regulation of ezrin phosphorylation, leading to ineffective erythropoiesis ultimately resulting in severe malarial anaemia. (biomedcentral.com)

The problem is, how do you get that chimera into the immune cell that you want to use for treatment. (kickingabs.com)
Through paracrine effects they differentiate into the damaged cells to restore function and continue to regulate the immune system and promote hormonal balance. (cellebrationlifesciences.com)
These cells can regulate the immune system and reduce the impact of autoimmune disorders. (cellebrationlifesciences.com)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
Griscelli syndrome type 2 (GS-2) is a rare, autosomal recessive immune deficiency syndrome caused by a mutation in the RAB27A gene, which results in the absence of a protein involved in vesicle trafficking and consequent loss of function of in particular cytotoxic T and NK cells. (biomedcentral.com)
Our ongoing and future studies aim to characterize immune functions of endothelial cell-induced DC-SIGN+ alternatively activated macrophages and to test whether DC-SIGN targeting could alter these functions both in vitro and in mouse models of SSc. (cnrs.fr)

The objective of this study is to explore the long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) expression profiles of monocyte-derived dendritic cells (DCs) obtained from peripheral blood mononuclear cells (PBMCs). (frontiersin.org)
PBMCs were separately isolated from the human peripheral blood of patients with AR and normal person (NP). (frontiersin.org)
The peripheral blood mononuclear cells (PBMCs) have a round nucleus ( Delves, 2016 ). (frontiersin.org)

Ruxolitinib has been shown to induce responses in refractory patients. (scielo.org)
Nivolumab (Opdivo) has been approved by the U.S. Food and Drug Administration (FDA) for use in patients with relapsed/refractory. (ascopost.com)

Korpershoek JV, Rikkers M, Wallis FSA, Dijkstra K, Te Raa M, de Knijff P, Saris DBF , Vonk LA. Mitochondrial Transport from Mesenchymal Stromal Cells to Chondrocytes Increases DNA Content and Proteoglycan Deposition In Vitro in 3D Cultures. (mayo.edu)
Comparison of human mesenchymal stromal cells from four neonatal tissues: Amniotic membrane, chorionic membrane, placental decidua and umbilical cord. (sciendo.com)

So with CAR T-cell therapy, CAR stands for chimerical antigen receptor. (kickingabs.com)
And from that point on, that cell, every time it divides, will express the chimeric antigen receptor. (kickingabs.com)
The mucosa-associated invariant T (MAIT) cells are innate-like T cells with restricted T cell receptor (TCR) usage, which are preferentially localized in mucosal tissues (liver, lung and gut) and respond to microbial infection by rapidly producing cytokines and cytotoxic effectors. (cryostem.org)
Using HLA-A2.1 transgenic mice, we have demonstrated the feasibility of T-cell receptor (TCR) gene transfer into T cells to circumvent self-tolerance to the widely expressed human p53 and MDM2 TAAs. (unimedizin-mainz.de)

Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. (scielo.br)

In Sweden, 350 new adult patients are diagnosed per year - there are slightly more males than females and the ages range from 18 years of age to nonagenarians. (cancercentrum.se)

The efficacy parameters in this study were myeloablation (defined as one or more of the following: absolute neutrophil count [ANC] less than 0.5x109/L, absolute lymphocyte count [ALC] less than 0.1x109/L, thrombocytopenia defined as a platelet count less than 20,000/mm³ or a platelet transfusion requirement) and engraftment (ANC greater than or equal to 0.5x109/L). All patients (61/61) experienced myeloablation. (clustermed.info)
RESULTS: At transplant all patients were transfusion-dependent and had splenomegaly (median bipolar diameter by ultrasound: 20.75 cm). (bvsalud.org)
At last follow-up, nine patients are currently alive and achieved transfusion-independence. (bvsalud.org)

CD34-selection of stem cells reduces the risk of aGvHD, but also leads to increased infectious complications and relapse. (frontiersin.org)
Consolidation therapy is based on the potential risk of relapse in patients who undergo induction therapy. (medscape.com)

Therefore, novel therapeutic methods for patients with ALF are urgently required. (springer.com)
Previous work from the contributing DKTK partner sites has demonstrated the versatility of this approach in T cells, and showed that it is feasible to derive CAR-engineered, established human NK cells as an off-the-shelf cellular therapeutic. (unimedizin-mainz.de)

5-azacytidine (AZA) has become standard treatment for patients with higher-risk myelodysplastic syndrome (MDS). (biomedcentral.com)
18. Del(5q) myelodysplastic syndrome combined with pure red cell aplasia. (whocc.org.cn)

Aim: To Describe our population of patients with AML and report the outcomes of our treatments. (scielo.org)
The outcomes were better in patients under 60 years. (scielo.org)
However, as the outcomes for patients with low- and intermediate-risk disease are similar, these categories have been collapsed into one and considered as low-risk disease. (nature.com)
Internal Fixation of Unstable Osteochondritis Dissecans of the Knee: Long-term Outcomes in Skeletally Immature and Mature Patients. (mayo.edu)

Added to this, there are patients who do not improve on any immunosuppressive treatment, with subsequent deteriorated quality of life and high mortality. (scielo.org)
Ruxolitinib treatment in patients with a very poor prognosis showed encouraging results. (scielo.org)
Elderly patients with secondary AML, high-risk genetics or significant co-morbidites should rather receive treatment with hypomethylating agents such as azacitidine, with or without venetoclax. (cancercentrum.se)
However, the aim of treatment may be dependent on the genetic risk and comorbidity, and some patients may need supportive care for infection before being eligible for treatment decision. (cancercentrum.se)
ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). (scielo.br)
The rationale for the proposed research is that when we are able to identify patients who are at particularly high risk for unresponsiveness to standard treatment and subsequent mortality, we can porpose customized treatment plans. (cryostem.org)
ST2, Reg3α, TNFR1, IL-6 will be validated on 300 matched aGvHD patient samples pre-treatment and 1month post-treatment. (cryostem.org)
We will validate this predictive panel on 300 matched cGvHD patients samples pre-treatment and 3 months post-treatment. (cryostem.org)
As shown in worldwide studies there is a considerable decrease in the antibodies against acetylcholine receptors after stem cell treatment was administered. (cellebrationlifesciences.com)
Patients often have a history of upper respiratory infection symptoms that have not improved despite empiric treatment with oral antibiotics. (medscape.com)
Discordant lymphomas of classic Hodgkin lymphoma and peripheral T-cell lymphoma following dupilumab treatment for atopic dermatitis. (u-tokyo-hemat.com)
Biopharma manufacturers must find solutions to enable the acceleration of the development of the diverse array of novel drug candidates in the pipeline and thus ensure that safe and effective novel treatment options can be brought to patients more quickly. (biopharminternational.com)
some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
But this treatment also destroys many healthy cells. (oncolink.org)
These cells can be used in future studies for the development of novel treatment options and to study the pathophysiology of GS-2 disease. (biomedcentral.com)
Use of a chronic model of articular cartilage and meniscal injury for the assessment of long-term effects after autologous mesenchymal stromal cell treatment in Steep. (sciendo.com)

2018). Development of bovine embryos in vitro in coculture with murine mesenchymal stem clls and embryonic fibroblasts. (sciendo.com)

Lymphoma b cell. (lookformedical.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Obinutuzumab and reduced bendamustine is effective for elderly patients with follicular lymphoma. (u-tokyo-hemat.com)

Bovine fetal mesenchymal stem cells exert antiproliferative efect against mastitis causing pathogen Staphylococcus aureus. (sciendo.com)
VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)

Alternatively, symptoms may be the result of organ infiltration with leukemic cells. (medscape.com)
Signs relating to organ infiltration with leukemic cells include hepatosplenomegaly and, to a lesser degree, lymphadenopathy. (medscape.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

Anatomy37

Organisms12

Diseases43

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

Psychiatry and Psychology2

Phenomena and Processes35

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science6

Named Groups4

Health Care19

Geographicals1

Transplantation29

Acute24

Chemotherapy12

Retinoic acid2

Progenitor4

Haematopoietic3

Graft-versus-2

Donor13

Regimen2

Transplants3

Hematopoietic stem cell2

Reconstitution1

Complete remission3

Differentiation8

Pluripotent stem1

Remission1

ATRA3

Marrow15

HSCT3

GvHD8

Hematology1

Leukemia8

Curative1

Clinical9

Therapies1

Characteristics1

Endothelial cells1

Lineages2

Pediatric1

Cancer10

Tumor7

Monoclonal1

Severe2

Immune6

Peripheral blood3

Refractory2

Mesenchymal Stromal Cells2

Receptor4

20191

Adult1

Transfusion3

Relapse2

Therapeutic2

Myelodysplastic2

Outcomes4

Treatment16

Embryonic1

Lymphoma5

Fetal2

Leukemic cells2

Vitro1