Patient s baseline dyspnea. Medical search. Frequent questions

cough, dyspnea, or wheeze), gastroesophageal reflux symptoms (GERS) and selfreported clinician-diagnosed asthma and GERD history were obtained from surveys. (cdc.gov)
4 The American Thoracic Society (ATS) and European Respiratory Society (ERS) define an exacerbation as an acute change in a patient's baseline dyspnea, cough, or sputum that is beyond normal variability, and that is sufficient to warrant a change in therapy. (aafp.org)
4 , 5 In addition to the hallmark symptoms of a COPD exacerbation (cough, dyspnea, and increased sputum), systemic inflammation also causes extrapulmonary symptoms ( Table 2 ). (aafp.org)
Bronchiectasis is a chronic (often suppurative) lung disease not traditionally included in the definition of COPD, but also characterised by airflow obstruction and symptoms including cough, sputum production, wheeze, dyspnoea, and decreased exercise tolerance. (bmj.com)
Patients with IPF typically present with symptoms of nonproductive cough and progressive dyspnoea. (ersjournals.com)
Pre-specified key symptoms were fatigue, appetite loss, cough, chest pain and dyspnoea, scored using the European Organisation for Research and Treatment of Cancer QLQ-C30 and QLQ-LC13 questionnaires (≥ 10-point difference = clinically relevant). (bvsalud.org)
The presence of dyspnoea or cough was independent of COPD severity. (unl.pt)

COPD clinical trials primarily focus on bronchodilator response using minimal clinically important difference (MCID) to determine improvements in lung function and patient-reported outcomes. (nature.com)
For patients with poor health care outcomes, the provision and participation in rehabilitation may increase their functional reserve and make a difference between surviving or succumbing to an acquired COVID-19 infection. (physio-pedia.com)
Nosocomial pneumonia serves as a paradigm for all severe infections, and appropriate antibiotic therapy is the key determinant of patient outcomes. (mims.com)
In this naturalistic outcome study, we investigated the effects of baseline anxiety and dyspnea-related fear on perceived dyspnea and other outcomes of a well-established pulmonary rehabilitation program for COPD. (nih.gov)
Substituting tiotropium for ipratropium in chronic obstructive pulmonary disease patients offers improved health outcomes and is associated with increased costs of 180 per patient per year. (ersjournals.com)
The meaningful outcomes observed reinforce the value of this precision medicine in treating RET -driven NSCLC and thyroid cancer and underscore Lilly's commitment to helping patients with cancer live healthier lives. (prnewswire.com)
Several studies comparing IPF with CTD-ILD indicate that patients with IPF experience poorer outcomes and survival 6 , 7 , 8 . (jrheum.org)
We hypothesized that patients with SSc-ILD may experience better outcomes than patients with other CTD-ILD because these patients undergo routine screening for ILD at our center. (jrheum.org)
The study aimed to demonstrate a significant difference in clinical, economic, and quality of life (QoL) outcomes in asthma patients who received enhanced pharmaceutical care compared with those who received usual care. (cdc.gov)
Outcomes measured included the percentage predicted forced expiratory volume in 1 second (FEV1%), percentage predicted carbon monoxide diffusion capacity (DLCO%), and dyspnea score per the University of California San Diego Shortness of Breath Questionnaire. (elsevierpure.com)
Outcomes were measured at baseline and 3 months. (elsevierpure.com)
PURPOSE: The clinical relevance of different time-to-deterioration (TTD) definitions for patient-reported outcomes were explored. (bvsalud.org)

81 dyspnoea descriptors were administered to 123 patients with chronic obstructive pulmonary disease (COPD), 129 with interstitial lung disease and 106 with chronic heart failure. (bmj.com)
Validity and reliability of the new instrument were further assessed in a separate group of 53 patients with COPD. (bmj.com)
COPD is a progressive disease in which many patients develop an acute or sustained deterioration. (nature.com)
CID was defined as any of the following: ≥100 mL decrease from baseline in pre-dose forced expiratory volume in 1 second (FEV 1 ), ≥4 point increase in St George's Respiratory Questionnaire score or a moderate-to-severe COPD exacerbation occurring after the first dose of study medication. (nature.com)
Patients had moderate (62%) or severe (38%) COPD. (nature.com)
5 The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 strategy now recommends that COPD management should consider both disease impact (i.e., assessment of symptoms) measured by the COPD Assessment Test (CAT) or modified Medical Research Council (mMRC) dyspnea scale, and exacerbation history. (nature.com)
Glycopyrronium is a once-daily LAMA indicated for the maintenance treatment of patients with COPD. (nature.com)
6 Phase III trials have shown that glycopyrronium produces rapid and sustained improvements in lung function, symptoms, health status, exercise endurance and exacerbation risk in patients with COPD. (nature.com)
The Standards for the Diagnosis and Treatment of Patients with COPD document 2004 updates the position papers on chronic obstructive pulmonary disease (COPD) published by the American Thoracic Society (ATS) and the European Respiratory Society (ERS) in 1995 1 , 2 . (ersjournals.com)
The main goals of the updated document are to improve the quality of care provided to patients with COPD and to develop the project using a disease-oriented approach. (ersjournals.com)
The current Standards for the Diagnosis and Treatment of Patients with COPD document is unique in that it also had input from patients suffering from COPD. (ersjournals.com)
However, more specific measures of dyspnea-related fear may be more closely related to critical processes involved in pulmonary rehabilitation (perception of dyspnea and avoidance of physical activity) and may have a predictive value for COPD outcome beyond general anxiety measures. (nih.gov)
The aim of this paper is to assess the health economic consequences of substituting ipratropium with the new, once-daily bronchodilator tiotropium in patients with a diagnosis of chronic obstructive pulmonary disease (COPD). (ersjournals.com)
Patients had a diagnosis of COPD and a forced expiratory volume in one second (FEV 1 ) ≤65% predicted normal. (ersjournals.com)
In the coming decades, general practitioners, respiratory physicians and other healthcare providers will be confronted with an increasing share of their patient population being COPD patients 2 . (ersjournals.com)
Tiotropium is a new inhaled bronchodilator for patients with COPD with a sustained duration of action indicated for once daily dosing 4 . (ersjournals.com)
This cost-effectiveness analysis was performed alongside two randomised controlled, double-blind, double-dummy, parallel group trials comparing 18 µg tiotropium inhalation capsules administered once daily in the morning via the HandiHaler® device with ipratropium 2 puffs of 20 µg administered four times daily via the metered dose inhaler (MDI) in patients with airway obstruction due to COPD 5 . (ersjournals.com)
In patients with known chronic obstructive pulmonary disease (COPD), exacerbations occur an average of 1.3 times per year. (aafp.org)
Inhaled bronchodilators (beta agonists, with or without anticholinergics) relieve dyspnea and improve exercise tolerance in patients with COPD. (aafp.org)
Short courses of systemic corticosteroids in patients with COPD increase the time to subsequent exacerbation, decrease the rate of treatment failure, shorten hospital stays, and improve FEV 1 and hypoxemia. (aafp.org)
Low-dosage corticosteroid regimens are not inferior to high-dosage regimens in decreasing the risk of treatment failure in patients with COPD. (aafp.org)
Oral prednisolone is equivalent to intravenous prednisolone in decreasing the risk of treatment failure in patients with COPD. (aafp.org)
Antibiotics should be used in patients with moderate or severe COPD exacerbations, especially if there is increased sputum purulence or the need for hospitalization. (aafp.org)
The choice of antibiotic in patients with COPD should be guided by symptoms (e.g., presence of purulent sputum), recent antibiotic use, and local microbial resistance patterns. (aafp.org)
Smoking cessation reduces mortality and future exacerbations in patients with COPD. (aafp.org)
Long-term oxygen therapy decreases the risk of hospitalization and shortens hospital stays in severely ill patients with COPD. (aafp.org)
Pulmonary rehabilitation is a multidisciplinary approach to treating patients with chronic lung disease and is advocated in American, 1 British 2 and European 3 guidelines on the management of chronic obstructive pulmonary disease (COPD) as an important component of medical care. (bmj.com)
Since pulmonary rehabilitation has traditionally focused on patients with COPD, its effectiveness in other chronic lung diseases has received little attention, although it has been implemented with clinical success in patients with cystic fibrosis 4 and in those with restrictive pulmonary defects. (bmj.com)
8 Theoretically, one would therefore expect pulmonary rehabilitation to be as effective in bronchiectasis as it is in COPD, but to date only one study has been performed which included only seven patients with the disease. (bmj.com)
The reduced exercise capacity and increased dyspnoea in patients with COPD is partly attributable to expiratory flow limitation resulting in dynamic hyperinflation and increased intrinsic positive end expiratory pressure, exacerbated by a reduction in inspiratory muscle force. (bmj.com)
Twenty seven patients with COPD‑AE were evaluated using a prospective longitudinal study design. (spandidos-publications.com)
Induced sputum, sera and nasal smears were sampled from patients experiencing COPD‑AE and those in a stable condition. (spandidos-publications.com)
Eighteen patients who experienced a COPD‑AE were also evaluated while in a stable condition. (spandidos-publications.com)
RSV serotype A was detected in 17/27 (63%) patients with COPD‑AE and 10/18 (55.6%) patients in a stable condition. (spandidos-publications.com)
Eight/ten patients who were positive for RSV serotype A while in a stable condition, were also positive during COPD‑AE. (spandidos-publications.com)
The results of the present study suggested that RSV infection may be prevalent in patients with COPD‑AE and in those in a stable condition. (spandidos-publications.com)
The aim of the present study was to investigate the prevalence of adenovirus and RSV A and B among patients with COPD-AE and those in a stable condition. (spandidos-publications.com)
The present study evaluated the association between viral infections, functional status and systemic inflammation in patients experiencing COPD-AEs and those in a stable condition. (spandidos-publications.com)
Pulmonary rehabilitation (PR) treatment is frequently considered for patients with chronic obstructive pulmonary disease (COPD). (e-arm.org)
PR is effective for decreasing symptoms, minimizing disease deterioration, and improving daily activities of patients with COPD [ 1 ]. (e-arm.org)
We excluded patients who were diagnosed with a cardiovascular disease, diabetes mellitus, hypertension, and COPD. (e-arm.org)
To determine the clinical and economic consequences of inhaled corticosteroid doses and particle size in patients on triple-inhalation therapy for COPD. (dovepress.com)
In patients with COPD receiving multi-inhaler triple therapy, higher ICS doses were not associated with a further reduction in exacerbations, whereas we found an increased risk of pneumonia. (dovepress.com)
1 , 2 COPD results in high healthcare costs, with the most severe patients and COPD exacerbations consuming the most resources. (dovepress.com)
1-3 In Spain, the direct mean cost per patient with COPD is estimated at €1712-3238/year, 50-70% of which are in hospital costs. (dovepress.com)
The purpose of this study is to determine the effects of Chinese traditional exercise such as t'ai chi and qigong (TCQ) on patients with chronic obstructive pulmonary disease (COPD). (yang-sheng.com)
All prospective, randomized, controlled clinical trials, published in English or Chinese and involving the use of TCQ by patients with COPD, were searched in 10 electronic databases from their respective inceptions to July 2012. (yang-sheng.com)
Introduction: The aim of this study was to determine patient-perceived characteristics of chronic obstructive pulmonary disease (COPD) in patients participating in a large trial evaluating tiotropium bromide. (unl.pt)
Conclusions: This analysis confirms the importance of dyspnoea as the most common symptom leading to initial COPD diagnosis and the symptom most troublesome to patients. (unl.pt)
Co-morbidities are common among COPD patients, and hence spirometric testing is appropriate in a patient who presents with dyspnoea associated with such a condition. (unl.pt)

Patients completed the EORTC Quality of Life Questionnaire-Core 30 and the Multidimensional Fatigue Inventory questionnaire at baseline and prespecified time points for 1 year. (medscape.com)
Broadly, such patients can be divided into those who may have serious sequelae (such as thromboembolic complications) and those with a non-specific clinical picture, often dominated by fatigue and breathlessness. (bmj.com)
Anxiety/depressive symptoms are common in patients with chronic fatigue syndrome- (CFS-) like illness. (yang-sheng.com)
To investigate the effects of Qigong on fatigue, anxiety, and depressive symptoms in patients with CFS-illness. (yang-sheng.com)
Fatigue, anxiety, and depressive symptoms were assessed at baseline and postintervention. (yang-sheng.com)
Qigong may not only reduce the fatigue symptoms, but also has antidepressive effect for patients with CFS-like illness. (yang-sheng.com)

While on TH, she developed severe dyspnea on exertion, her LVEF declined to 45%, and she developed ST T-wave abnormalities on ECG. (cancernetwork.com)
We conducted pulmonary function testing (PFT) and used a visual analog scale (VAS) to evaluate pain, and the modified Borg Dyspnea Scale (mBS) to measure perceived respiratory exertion shortly before and 2 weeks, 1, 3, and 6 months after surgery. (e-arm.org)
Dyspnea or perceived exertion during exercise is most commonly measured using Borg or visual analog scales, created for use in adults. (springeropen.com)
We sought to validate our newly created, pictorial Dalhousie Dyspnea and Perceived Exertion Scales in adult populations and compare ratings with the Borg scale. (springeropen.com)
Dyspnea and perceived exertion ratings obtained with both modified Borg CR-10 and Dalhousie scales during maximal cycle exercise were compared in 24 healthy adults and 17 with various pulmonary disorders. (springeropen.com)
Scale ratings for perceived exertion were plotted against work while ratings for dyspnea were plotted against ventilation using previously developed alternative models to simple power law. (springeropen.com)
Pictorial ratings of dyspnea and perceived exertion measured by both scale ratings rose as expected with increasing exercise intensity, and individual trajectories obtained by either scale were virtually superimposable in 90 % of subjects. (springeropen.com)
The Dalhousie Dyspnea and Exertion Scales offer an equally good alternative to the Borg scale for measuring dyspnea and perceived exertion in adults. (springeropen.com)
Dalhousie Dyspnea and Perceived Exertion Scales offer an alternative to Borg CR-10 scale in adults and were preferred by half our healthy subjects. (springeropen.com)
Most healthy subjects appear to have a lag or delay below which they report minimal changes in dyspnea or perceived exertion during incremental exercise, whereas most pulmonary patients do not, particularly for dyspnea. (springeropen.com)
Quadratic-delay model display improved fitting of observed trajectories of dyspnea perceived exertion during incremental, maximal exercise over simple power function. (springeropen.com)
We created an alternative scale for use in children and adolescents, Dalhousie pictorial scales [ 11 ], to measure dyspnea and perceived exertion during work requiring leg exercise such as cycling or running. (springeropen.com)
We reported that the Dalhousie scales accurately track dyspnea and perceived exertion during a maximal exercise test in a pediatric population of individuals with and without respiratory disease [ 12 ]. (springeropen.com)
We now report validation studies for our Dalhousie Dyspnea and Perceived Exertion Scales in adults, both healthy and with pulmonary disease, via three steps: (1) comparison with the current "gold standard," i.e. (springeropen.com)

The SENSCIS® trial demonstrated a significant reduction of lung function decline in patients with SSc-associated interstitial lung disease (SSc-ILD) treated with nintedanib, but no significant effect on health-related quality of life (HRQoL). (nih.gov)
At baseline, higher dyspnea-related fear was associated with higher levels of dyspnea during ergometer exercise, but also with a steeper decrease of exercise dyspnea during the course of pulmonary rehabilitation, whereas lower dyspnea-related fear was associated with an increase in exercise dyspnea, even when controlling for anxiety, lung function, and exercise intensity. (nih.gov)
A recent double-blind placebo-controlled study showed that patients with SSc-ILD treated with 1 year of oral cyclophosphamide experienced a statistically significant improvement in lung function, dyspnea, and health-related quality of life compared with those treated with placebo 15 , 16 . (jrheum.org)
IPF can have a variable course with some patients experiencing a progressive deterioration in lung function, while others develop acute exacerbations leading to rapid respiratory failure and early death [ 2 ]. (ersjournals.com)

The patient experiences symptoms of increase in dyspnea, sputum volume and sputum purulence over baseline on most days. (mims.com)
Oral corticosteroids are likely beneficial, especially for patients with purulent sputum. (aafp.org)
Physicians should consider antibiotics for patients with purulent sputum and for patients who have inadequate symptom relief with bronchodilators and corticosteroids. (aafp.org)
The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. (spandidos-publications.com)

Methods: We studied 36,897 participants in the WTC Health Registry, a cohort of exposed rescue/recovery workers and community members, who completed baseline (2003-2004) and follow-up (2015-16) questionnaires. (cdc.gov)
Methods: Eligible patients with stage I NSCLC tumors 3 cm or smaller were randomly allocated to undergo sublobar resection with (SRB group) or without (SR group) brachytherapy. (elsevierpure.com)
METHODS: Th is was a multicenter registry study of patients undergoing therapeutic bronchoscopy for malignant central airway obstruction. (psu.edu)
METHODS: This open-label, phase 1b study enrolled patients with advanced EGFR-mutated NSCLC. (bvsalud.org)
METHODS: TTD definitions differing by reference score and deterioration event were used to analyse data from the phase 3 FLAURA trial of first-line osimertinib versus erlotinib or gefitinib in patients with EGFR-mutated advanced non-small cell lung cancer. (bvsalud.org)
Patients and methods: Baseline symptoms were assessed by means of a standardized questionnaire. (unl.pt)

Retrospective analysis revealed that patients with the most severe hyperinflation of their lungs (as determined by a residual volume to total lung capacity ratio above the median) derived the greatest benefit from airway bypass. (medgadget.com)
Gene expression signatures within memory B cells suggest qualitative differences in the antibody responses in aged patients with severe disease. (medrxiv.org)
Examination of T cells showed profound lymphopenia, that worsened over time and correlated with lower levels of plasma cytokines important for T cell survival in aged patients with severe disease. (medrxiv.org)
We aim to recruit 75 VCI patients, 60 HFpEF patients, 60 patients with severe aortic stenosis (AS) undergoing surgical aortic valve replacement as a pressure overload HFpEF model, and 200 elderly participants with mixed comorbidities to serve as controls. (unav.edu)
We report a case of severe hemorrhage in a patient with CLL who was not on prior anti-platelet therapy or anticoagulation. (fortuneonline.org)
3. Dyspnea due primarily to non-cardiac causes (e.g., severe chronic obstructive pulmonary disease or pneumonia). (who.int)

For an incurable disease like multiple myeloma, a major treatment goal for oncologists and hematologists is to help patients live as long as possible," said study co-author and investigator Meletios A. Dimopoulos, M.D., professor of Clinical Therapeutics at the National and Kapodistrian University of Athens , School of Medicine. (amgen.com)
The KYPROLIS clinical program continues to focus on providing solutions for physicians and patients in treating this frequently relapsing and difficult-to-treat cancer. (amgen.com)
At 15 months median follow-up, there were four cases of clinical CHF during treatment (1.7%), including one patient during TH and three after receiving the AC regimen. (cancernetwork.com)
Select patients for treatment with RYBREVANT based on the presence of EGFR exon 20 insertion mutations in tumor or plasma specimens [see Clinical Studies (14) ]. (drugs.com)
1 Clinical management requires a whole-patient perspective. (bmj.com)
Has been reported in 2% patients in clinical trials. (blackboxrx.com)
After bringing the first FDA-approved RET inhibitor to patients earlier this year, we are pleased to follow up with detailed safety and efficacy findings from the largest clinical trial in patients with RET -driven cancers," said Anne White , president of Lilly Oncology. (prnewswire.com)
Given that patients living with RET fusion-positive NSCLC face a high lifetime risk of disease progression to the brain, intracranial effectiveness is a significant consideration in the treatment journey," added Vivek Subbiah , M.D., associate professor of Investigational Cancer Therapeutics and medical director of the Clinical Center for Targeted Therapy at The University of Texas MD Anderson Cancer Center and co-investigator for LIBRETTO-001. (prnewswire.com)
We compared the clinical features and survival of patients with SSc-ILD to those with ILD associated with other CTD (non-SSc CTD-ILD), including RA, SLE, PM/DM, Sjögren's syndrome, and MCTD. (jrheum.org)
BACKGROUND: Because as many as 46% of implantable cardioverter defibrillator (ICD) patients experience clinical symptoms of shock anxiety, this randomized controlled study evaluated the efficacy of adapted yoga (vs usual care) in reducing clinical psychosocial risks shown to impact morbidity and mortality in ICD recipients. (yang-sheng.com)
Changes from baseline in forced vital capacity (FVC) and diffusing capacity of the lung for carbon monoxide ( D L,CO ) were primary end-points, while secondary end-points included clinical, radiological and physiological score, high-resolution computed tomography (HRCT) findings, quality of life (QoL) and survival. (ersjournals.com)
The abstracts, including five oral presentations, highlight updated and interim efficacy and safety clinical trial results for ADCETRIS in both early- and advanced stage settings of classical Hodgkin lymphoma (cHL), and in patients with other CD30-expressing lymphomas and other rare cancers. (businesswire.com)
So, I'll be giving a brief introduction to long COVID where we hear from our two wonderful speakers on their clinical experience managing patients at post-acute COVID clinics. (cdc.gov)

Problems caused by hiccups included weight loss, dyspnea, and insomnia. (medscape.com)

Patients also showed a statistically significant improvement in the modified Medical Research Council Dyspnea Scale (mMRC), a breathlessness test, of -0.5 points (p= 0.025). (medgadget.com)

Patient-reported outcome (PRO) measures [St. George's Respiratory Questionnaire (SGRQ), Functional Assessment of Chronic Illness Therapy (FACIT)-Dyspnoea, and HAQ-Disability Index (HAQ-DI), incorporating the Scleroderma HAQ visual analogue scale (SHAQ VAS)] at baseline and week 52 were assessed for associations to SSc-ILD severity. (nih.gov)
10 on the Patient Health Questionnaire (PHQ). (cdc.gov)
The percentages of patients with a relevant improvement on the St. George's Respiratory Questionnaire (SGRQ) were 34.6% and 51.2% respectively. (ersjournals.com)
QoL was assessed using the European Organization of Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) measured at baseline and at the end of the treatment period. (naturalmedicinejournal.com)
To assess the feasibility of QOL assessment in a cohort of Tunisian cancer patients, the EORTC QLQ-C30 questionnaire was administered to 23 women treated with adjuvant chemotherapy for early breast cancer on an outpatient basis at baseline and during the 3rd cycle of chemotherapy. (who.int)
Afin d'estimer la faisabilité d'une évaluation de la qualité de vie dans une cohorte de patients cancéreux tunisiens, nous avons présenté le questionnaire QLQ-C30 de l'EORTC à 23 femmes traitées par chimiothérapie adjuvante en ambulatoire pour un cancer du sein à un stade précoce, au début du traitement et pendant le troisième cycle de chimiothérapie. (who.int)
We assessed the acceptability of the immediate and long-term adverse effects questionnaire by estimating the rate of miss- which significantly affect patients' QOL. (who.int)

Adverse events seen in the trial included headache, nausea, diarrhea, and flushing, which are common in patients receiving prostanoid therapy. (rtmagazine.com)

5 New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, UMC Comprehensive Pulmonary Hypertension Center and Interstitial Lung Disease Clinic Programs, Louisiana State University and Tulane University Schools of Medicine, New Orleans, LA. (nih.gov)
To compare survival of patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) versus idiopathic pulmonary fibrosis (IPF) and patients with systemic sclerosis-associated ILD (SSc-ILD) versus other CTD-ILD followed at our center. (jrheum.org)

Tiotropium was also found to be more effective in improving dyspnoea, exacerbations and health-related quality of life. (ersjournals.com)
Hospitalized patients with exacerbations should receive regular doses of short-acting bronchodilators, continuous supplemental oxygen, antibiotics, and systemic corticosteroids. (aafp.org)
Prognosis remains poor, especially among the subgroup of patients who develop acute exacerbations [ 2 ]. (ersjournals.com)

Patients with diffuse cutaneous SSc and other characteristics associated with SSc-ILD severity had worse PRO measure scores. (nih.gov)
Baseline characteristics for the overall population were similar. (nature.com)
Patient characteristics at baseline. (archbronconeumol.org)
There were no differences in baseline characteristics between arms. (elsevierpure.com)

Carbon dioxide levels also may be monitored, since patients with prior lung disease such as asthma and chronic obstructive pulmonary disease may be affected more severely and are at greater risk to retain carbon dioxide. (medscape.com)

Patients may also benefit from pulmonary rehabilitation interventions - this targets physical and respiratory impairments and include a combination of graded exercise, education, activities of daily living and psychosocial support. (physio-pedia.com)
Exercise in pulmonary rehabilitation in people with higher baseline dyspnea-related fear may act as a correction of excessive symptom reports through exposure to dyspneic situations. (nih.gov)
The role of pulmonary rehabilitation (PR) and inspiratory muscle training (IMT) has not been investigated in this group of patients. (bmj.com)
To investigate the efficacy of systemic pulmonary rehabilitation (PR) after lung resection in patients with lung cancer. (e-arm.org)

5 Guidelines recommend long-acting bronchodilator therapy, including long-acting muscarinic antagonists (LAMAs), as a first choice therapy in all GOLD patient groups. (nature.com)
These results further support KYPROLIS as a foundational therapy in this patient population. (amgen.com)
The team randomly assigned 148 patients to surgery to reduce tumor burden by at least 80% followed by systemic therapy and 152 other patients to systemic therapy alone. (medscape.com)
Overall, 43% of patients in the surgery arm had serious adverse events vs 21% of patients who received stand-alone systemic therapy ( P ≤ .001). (medscape.com)
The fact that local therapy associated serious side effects did not translate to a noticeable dip in the patients' perceived quality of life is quite intriguing" and "could mean that the negative impact of complications on quality of life is temporary and eventually balances out with a decrease in tumor-related symptoms after treatment," lead author Lotte Bakkerus, MD, Radboud Institute for Health Sciences, the Netherlands, said in a press release. (medscape.com)
[ 4 , 6 ] It was concluded that VNS is safe and well tolerated, with nearly three quarters of the patients choosing to continue therapy. (medscape.com)
The effect of cyclophosphamide therapy on longterm survival in patients with SSc-ILD is still unclear. (jrheum.org)
Patients aged ≥ 40 years who initiated treatment with multi-inhaler triple-inhaled therapy between 1 January 2015 and 31 March were included and followed for 1 year. (dovepress.com)
Qigong as a modality of complementary and alternative therapy has been increasingly applied by patients with chronic illnesses, but little is known about the effect of Qigong on anxiety/depressive symptoms of the patients with CFS-like illness. (yang-sheng.com)
A goal of the pharmaceutical care was to involve the patient in his/her therapy and provide sufficient support for self-management, which in turn would change the patients' behaviors so that they would be able to control their asthma. (cdc.gov)
The effects of the combined therapy were studied in patients with previously untreated metastatic prostate cancer. (guidelinecentral.com)
This is the first FDA approval for an anti-PD-L1 therapy as part of a combination regimen for patients with advanced RCC. (pfizer.com)
Patients do not need] false hope that is personified in useless therapy with nontherapeutic effect. (pallimed.org)
For patients with impairing CBD, corticosteroid therapy continues to be the primary treatment modality (Glazer and Newman 2003). (cdc.gov)
1999). Before initiating corticosteroid therapy, a baseline chest radiograph, high resolution CT, complete pulmonary function tests (including lung volumes, spirometry, and diffusing capacity), and exercise testing, with arterial blood gas measurements, should be performed. (cdc.gov)
Patients should be monitored for therapy-induced side effects on an ongoing basis. (cdc.gov)

Dyspnoea is a debilitating and distressing symptom that is reflected in different verbal descriptors. (bmj.com)
Patients reported symptoms that led to diagnosis as well as their current most troublesome symptom. (unl.pt)

Hypotension: Not recommended for patients for whom vasodilating agents are not appropriate, or other conditions in which cardiac output is dependent upon venous return, or for patients suspected to have low cardiac filling pressures. (nih.gov)

The trial results also showed that the combined 6MWD and Borg Dyspnea Score rating (shortness of breath test) was significantly improved (p=0.0497). (rtmagazine.com)
Significant worsening of baseline shortness of breath. (medlineplus.gov)

Inappropriate pacing in patients with decreased ventricular compliance, which may be caused by diseases such as hypertensive cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, and aging, can result in loss of atrial contraction and significantly reduces cardiac output. (wikipedia.org)
Maximal palliative tumor debulking does not significantly affect overall quality of life among patients with metastatic colorectal cancer . (medscape.com)
Healthcare related quality-of-life at 1 year was also not significantly different from baseline in either group. (medscape.com)
Conclusions: Adjuvant intraoperative brachytherapy in conjunction with sublobar resection did not significantly worsen pulmonary function or dyspnea at 3 months in a high-risk population with NSCLC, nor was it associated with increased perioperative pulmonary adverse events. (elsevierpure.com)

All patients were asked to complete a monthly Asthma Calendar Diary where they recorded their peak expiratory flow rate (PEFR), a twice-daily scale, medical visits, emergency or hospital visits, and lost school/work days. (cdc.gov)

The objective of this study was to develop an instrument that measures overall dyspnoea severity using descriptors that reflect its different aspects. (bmj.com)
It provides a global score of breathlessness severity that incorporates both "physical" and "affective" aspects, and can measure dyspnoea in a variety of diseases. (bmj.com)
This study captures the longitudinal immune response to SARS-CoV-2 infection in a cohort of young and aged patients with varying disease severity. (medrxiv.org)
The baseline level of breathlessness varied in severity. (ahrq.gov)

In this population, the use of NATRECOR reduced pulmonary capillary wedge pressure and improved symptomatic dyspnea when measured at 3 hours of infusion. (nih.gov)

The contradictory results in these studies may be related to differences in the patient populations with respect to CTD diagnosis. (jrheum.org)

Once the surge in acute cases of COVID-19 patients has subsided, there will be an increase in rehabilitation needs of these patients following discharge from hospital. (physio-pedia.com)
ABSTRACT Using data from the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE-2) in 2008-09 we investigated the in-hospital complications and 1-year outcome of acute coronary syndrome (ACS) in patients with systemic hypertension from 6 Gulf countries. (who.int)
There is an acute need for more effective treatment options to reduce the burden of this disease for patients, caregivers and society. (ersjournals.com)
The specialist rehabilitation needs of a third group, covid-19 patients whose acute illness required intensive care, have been covered elsewhere. (bmj.com)
An 85-year-old male with history of CLL started on a reduced dose of ibrutinib presented with acute onset left sided flank pain and dyspnea. (fortuneonline.org)
The patient was managed conservatively with intravenous hydration for his acute renal failure, blood transfusions and pain medications. (fortuneonline.org)
At the conclusion of this session, participants will be able to accomplish the following: Identify signs and symptoms of long COVID which occur after the acute phase of SARS-CoV-2 infection, identify potential multidisciplinary teams for patient care, describe common challenges to post-acute COVID-19 care, and finally, describe examples of patient-centered, interdisciplinary, post-acute COVID-19 care. (cdc.gov)
I'm sure you've seen reports like some of the ones shown on this slide describing patients with ongoing and sometimes debilitating symptoms many months after acute SARS-CoV-2 infection. (cdc.gov)

The issues still prevalent in a patient recovering from COVID-19 following discharge will guide and inform the patient's care and support plan. (physio-pedia.com)

In the case of FEV1%, percentage change from baseline to 3 months was significant within the SR arm (P = .03), with patients reporting improvement in FEV1% at month 3. (elsevierpure.com)
The median change from baseline was 25 meters for oral treprostinil and -5 meters for placebo at week 12. (rtmagazine.com)

A unique feature of this project was the development of a patient document that could serve as a formal source of information for the patients, thereby making them partners in the effort to decrease the burden of the disease. (ersjournals.com)
Patients in the extended-care group experienced a 50% decrease in symptoms over the 12-month study period and PEFRs that were 11% higher than the usual-care group's readings, a statistically significant difference. (cdc.gov)

RYBREVANT is indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion mutations, as detected by an FDA-approved test [see Dosage and Administration (2.1) ] , whose disease has progressed on or after platinum-based chemotherapy. (drugs.com)

[ 3 ] which compared the efficacy and safety of VNS in patients who received high stimulation vs. low stimulation. (medscape.com)
NEJM published separate articles focusing on efficacy and safety data in the RET fusion-positive NSCLC and RET -altered thyroid patient cohorts independently, with data demonstrating durable objective responses across both patient populations. (prnewswire.com)
To compare the safety and efficacy of high-dose vitamin D supplementation tailored to baseline deficiency levels with conventional vitamin D supplementation in women with early breast cancer. (naturalmedicinejournal.com)
The primary efficacy endpoint of the trial was the change in 6MWD at 12 weeks for the 228 patients. (rtmagazine.com)

Therefore, guidelines have been published recommending that all patients with SSc undergo baseline and annual screening for ILD with pulmonary function testing and chest imaging 13 , 14 . (jrheum.org)

Immediately withhold RYBREVANT in patients with suspected ILD/pneumonitis and permanently discontinue if ILD/pneumonitis is confirmed. (drugs.com)

and (2) indirectly, by asking the respondent to report the level of physical activity they are not able to accomplish because of dyspnoea, 7 8 or within scales assessing the impact of disease on quality of life. (bmj.com)
Furthermore, higher dyspnea-related fear was associated with reduced quality of life (mastery subscale) and maximal exercise capacity at baseline, but also with a steeper increase in quality of life (emotions and mastery subscale) and exercise capacity during rehabilitation. (nih.gov)
Patients who received lung resection suffered a significant decline in functional reserve and increases in pain and subjective dyspnea deteriorating quality of life (QoL). (e-arm.org)
ABSTRACT Limited research has been devoted to quality of life (QOL) of cancer patients in develop- ing countries. (who.int)

The study met the key secondary endpoint of OS, demonstrating that patients with relapsed or refractory multiple myeloma treated with KYPROLIS ® (carfilzomib) and dexamethasone (Kd) lived 7.6 months longer than those treated with Velcade ® (bortezomib) and dexamethasone (Vd) (median OS 47.6 months for Kd versus 40.0 for Vd, HR = 0.79, 95 percent CI, 0.65 - 0.96). (amgen.com)
Median seizure reductions compared with baseline were 35% at one year, 44.3% at two years, and 44.1% at three years. (medscape.com)
After a median followup of 4 years, 67 patients (36.4%) had died and 4 (2.2%) were lost to followup. (jrheum.org)
Preliminary analysis of the trial results demonstrated that those patients receiving oral treprostinil improved their median 6MWD by approximately 23 meters (p=0.0125, Hodges-Lehmann estimate and non-parametric analysis of covariance in accordance with the trial's pre-specified statistical analysis plan) as compared to patients receiving placebo. (rtmagazine.com)
An analysis of all 349 FREEDOM-M patients demonstrates that those patients receiving oral treprostinil improved their median 6MWD by approximately 25.5 meters (p=0.0001, Hodges-Lehmann estimate and non-parametric analysis of covariance) as compared to patients receiving placebo. (rtmagazine.com)

The publication highlights the first 105 consecutively enrolled RET fusion-positive metastatic NSCLC patients treated with at least prior platinum-based chemotherapy as well as 39 systemic treatment naïve patients. (prnewswire.com)
Analysis of blood, urine, and feces samples following a single oral 150-mg dose of [ 14 C]-nilutamide in patients with metastatic prostate cancer showed that the drug is rapidly and completely absorbed and that it yields high and persistent plasma concentrations. (guidelinecentral.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)

Symptoms commonly documented in patients history, classified according to cause: Neurological - Dizziness, near syncope, and confusion. (wikipedia.org)
One patient complained of dizziness, which subsided. (medscape.com)

In spite of that and their "proven benefit only in patients with a reduced ejection fraction, beta-blockers were still commonly used in SPRINT," Dr. Meyer noted. (medpagetoday.com)
The most commonly reported co-morbidities were cardiovascular disorders (49% of patients), gastrointestinal disorders (20%) and metabolic disorders (16%), mainly diabetes mellitus. (unl.pt)

Among hypertensive patients, the mortality rate was higher only among those admitted with ST-elevation myocardial infarction. (who.int)
There were no significant differences in mortality in hypertensive ACS patients when stratified by sex, age or ethnicity. (who.int)
The use of antibiotics reduces the risk of treatment failure and mortality in moderately or severely ill patients. (aafp.org)
We also identified factors predictive of mortality in patients with CTD-ILD. (jrheum.org)

diovascular disease, including stroke, RACE-2, which was a 9-month prospec- Systemic hypertension was defined in coronary artery disease (CAD), heart tive, multicentre study of 7847 consecu- the current registry as: either history of failure and peripheral vascular dis- tive patients with ACS from 6 adjacent hypertension diagnosed and treated ease [1-3]. (who.int)
Background In patients with suspected coronary artery disease (CAD), myocardial perfusion is assessed under rest and pharmacological stress to identify ischemia. (unav.edu)

Patients were randomised to tiotropium (18 µg once daily) or ipratropium (2 puffs of 20 µg administered four times daily) in a ratio of 2:1. (ersjournals.com)

The clinically meaningful responses observed in this study demonstrate that selpercatinib can help fill this need, offering a valuable treatment option to these patients. (prnewswire.com)
A 10% change in pulmonary function test or 10-point change in dyspnea score was deemed clinically meaningful. (elsevierpure.com)
There was no significant difference in incidence of clinically meaningful (10% pulmonary function or 10-point dyspnea score change) change between arms. (elsevierpure.com)

We included 48 RCTs and 2 retrospective cohort studies (4,029 patients). (ahrq.gov)

All patients included in our analyses were enrolled in the Stanford ILD Database (n = 427), a prospective collection of information on patients with ILD evaluated at Stanford Hospital and Clinics between January 1, 2002, and January 1, 2009. (jrheum.org)

Seventy-three patients participated in the study. (nih.gov)
For this common and most important risk respectively), were recruited from 65 study, patients were analysed according factor for stroke and intracerebral hospitals. (who.int)
A recent study found an association between use of beta-blockers to lower blood pressure and an increased incidence of heart failure in patients without heart failure at baseline. (medpagetoday.com)
The study enrolled both treatment-naive patients and heavily pretreated patients with a variety of advanced solid tumors including RET fusion-positive NSCLC, RET -mutant MTC, RET fusion-positive thyroid cancer, and certain other advanced solid tumors with RET alterations. (prnewswire.com)
A case control study with 74 patients diagnosed with lung cancer and who underwent lung resection surgery at our hospital from October to December 2010 were enrolled. (e-arm.org)
The study included 225 patients. (cdc.gov)
In a double-blind, randomized, multicenter study that enrolled 457 patients (225 treated with orchiectomy and NILANDRON, 232 treated with orchiectomy and placebo), the NILANDRON group showed a statistically significant benefit in time to progression and time to death. (guidelinecentral.com)
Impact of a tailored oral vitamin D supplementation regimen on serum 25-hydroxyvitamin D levels in early breast cancer patients: a randomized phase III study. (naturalmedicinejournal.com)
Background: Z4032 was a randomized study conducted by the American College of Surgeons Oncology Group comparing sublobar resection alone versus sublobar resection with brachytherapy for high-risk operable patients with non-small cell lung cancer (NSCLC). (elsevierpure.com)
Updated results will also be presented from a phase 1 study of the investigational agent SEA-BCMA in patients with relapsed/refractory multiple myeloma. (businesswire.com)
The study enrolled 349 patients who were not receiving any approved PAH medication, with the population for the primary analysis consisting of the 228 patients who had access to the 0.25 mg tablet at randomization. (rtmagazine.com)
All patients in the trial had the option to continue receiving oral treprostinil in an open-label continuation study after completion of the 12-week period. (rtmagazine.com)
Of the 287 patients who were eligible to enroll, approximately 279 patients entered the open-label continuation study. (rtmagazine.com)
The team reviewed records of patients with a history of unsuccessful treatments for hiccups from 2008 to 2014, and they included 28 patients with intractable hiccups and a history of unsuccessful medical treatment with gabapentin and baclofen in the study. (medscape.com)
The biggest limitation of the study is that while the patients were receiving a bolus/continuous epidural infusion, they were also undergoing other treatments (not defined) designed at addressing the causative factors for the hiccups," noted Dr. Christiansen, who was not involved in the study. (medscape.com)
If the study would be repeated, I would suggest that the researcher consider randomizing the patients into two groups: group 1 gets the epidural bolus/infusion while group 2 gets treatment for their causative factors. (medscape.com)
While the paper states that there were no adverse events reported, I wonder how many patients required a 'hemodynamic intervention' in order to safely complete the study. (medscape.com)
3. Patients = 18 years of age able to provide informed consent and comply with study procedures. (who.int)

Th erapeutic bronchoscopy should not be withheld from patients based solely on an assessment of risk, since patients with the most dyspnea and lowest functional status benefi tted the most. (psu.edu)

Like other chronic illnesses, diabetes mellitus poses a wide range of problems for patients and their family members. (cdc.gov)

Results indicate a mediating effect of dyspnea-related fear on the association between anxiety and exercise-related dyspnea. (nih.gov)

Results: Data were obtained from 298 patients, mostly male (95%), with mean (standard deviation) baseline forced expiratory volume in 1 second of 1.1 (0.4) L (40.6 [13.3] % of predicted), mean disease duration of 14.4 (10.1) years and smoking history of 55.1 (25.3) pack-years. (unl.pt)

KYPROLIS is available for patients whose myeloma has relapsed or become resistant to another treatment and continues to be studied in a range of combinations and patient populations. (amgen.com)
Group think' among various 'non-hypertension' guideline committees and a limited understanding of the evidence-basis of beta-blockers in other disease entities may have also inadvertently contributed to the continued over-prescription of beta-blockers in patient populations with normal ejection fractions. (medpagetoday.com)

Dyspnoea is a perceptual experience that is complex and highly subjective. (bmj.com)
Dyspnea is defined as a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity [ 1 ]. (springeropen.com)

Studies have shown that patients with Pacemaker syndrome and/or with sick sinus syndrome are at higher risk of developing fatal complications that calls for the patients to be carefully monitored in the ICU. (wikipedia.org)
RÉSUMÉ À partir de données du deuxième Registre des événements coronariens aigus du Golfe (Gulf RACE-2), pour la période 2008 - 2009, nous avons enquêté sur les complications à l'hôpital et sur l'issue à un an d'un syndrome coronarien aigu chez des patients atteints d'hypertension artérielle systémique dans six pays du Golfe. (who.int)
This evaluates early impact of adjuvant brachytherapy on pulmonary function tests, dyspnea, and perioperative (30-day) respiratory complications in this impaired patient population. (elsevierpure.com)
In generalized systemic sclerosis with diffuse skin involvement, patients have Raynaud syndrome and gastrointestinal (GI) complications. (msdmanuals.com)

Nonetheless, loss, constipation and diarrhoea) and fi- most patients with operable disease have nancial difficulties. (who.int)

Patients who got Herceptin for 10 weeks probably still had a significant amount of Herceptin on board when they got AC. (cancernetwork.com)
The NHS in the United Kingdom has predicted that these patients will have significant physical, neuropsychological, and social needs on discharge from hospital. (physio-pedia.com)
There was no significant change in percentage change in DLCO% or dyspnea score from baseline to 3 months within either arm. (elsevierpure.com)
Multivariable regression analysis (adjusted for baseline values) showed no significant impact of treatment arm, tumor location (upper vs other lobe), or surgical approach (video-assisted thoracoscopic surgery vs thoracotomy) on 3-month FEV1%, DLCO%, and dyspnea score. (elsevierpure.com)

Most data for the use of antibiotics are derived from studies in non-ICU patients and ignore critical care issues such as fluid resuscitation, mechanical ventilation, and changing renal function. (mims.com)
At 3-month follow-up, pulmonary function data are currently available for 148 (74 SR and 74 SRB) patients described in this report. (elsevierpure.com)

1. Inability to place Foley catheter or IV catheter or other urologic issues that would predispose the patient to a high rate of urogenital trauma or infection with catheter placement. (who.int)

After adjustment for baseline variables, hypertension was an independent predictive factor for heart failure (OR = 1.31) and stroke (OR = 2.47). (who.int)
Using Beta-Blockers to Lower Blood Pressure in Patients Without Heart Failure at Baseline: Worth the Risk? (medpagetoday.com)
A disturbing association between use of beta-blockers to lower blood pressure and an increased incidence of heart failure, in patients without heart failure at baseline, has been demonstrated in a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). (medpagetoday.com)
Providers often assume that the benefits of beta-blockers in heart failure with a reduced ejection fraction extend to other patient groups as well," Dr. Meyer observed. (medpagetoday.com)
NATRECOR is a natriuretic peptide indicated for the treatment of patients with acutely decompensated heart failure who have dyspnea at rest or with minimal activity. (nih.gov)

Of 7847 consecutive patients admitted with ACS, 3746 (47.7%) had hypertension. (who.int)
Patients with hypertension were more likely than those without hypertension to present with dyspnoea and advanced Killip class. (who.int)
In an interview with MedPage Today , it was clear that Dr. Meyer felt beta-blockers were often used inappropriately for patients with hypertension in SPRINT and in the general population. (medpagetoday.com)
United Therapeutics Corp , Silver Spring, Md, has completed its FREEDOM-M phase 3 trial of treprostinil diethanolamine (oral treprostinil) , an investigational sustained-release oral formulation of treprostinil, a stable synthetic form of prostacyclin, in patients with pulmonary arterial hypertension (PAH). (rtmagazine.com)

Both nonpharmacological and pharmacological interventions led to adverse event-related dropouts in a small percentage of patients. (ahrq.gov)
In the SR arm, 9 patients (12%) reported grade 3 respiratory adverse events, compared with 12 (16%) in the SRB arm (P = .49). (elsevierpure.com)

[ 5 ] found that when used in conjunction with a multidisciplinary and multimodality treatment regimen, more than 60% of patients experienced at least a 50% reduction in seizure burden. (medscape.com)
Patients with evidence of early lung damage are treated with 40 mg of prednisone on a daily or alternate day regimen for 6 months. (cdc.gov)

Multiple myeloma in patients whose disease has relapsed or is refractory despite receiving ≥1 previous drug therapies (as monotherapy). (unboundmedicine.com)
Multiple myeloma in patients whose disease has relapsed or is refractory despite receiving 1-3 previous drug therapies (in combination with dexamethasone, or lenalidomide + dexamethasone, or daratumumab + dexamethasone, or daratumumab/hyaluronidase + dexamethasone, or isatuximab + dexamethasone). (unboundmedicine.com)

Diseases2

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Anthropology, Education, Sociology and Social Phenomena1

Health Care4

Cough7

Outcomes12

COPD50

Fatigue6

Exertion14

Lung function4

Sputum4

Methods6

Severe6

Clinical13

Insomnia1

Showed a statistically significant improvement1

Questionnaire7

Nausea1

Interstitial lung di2

Exacerbations3

Characteristics4

Chronic obstruc1

Pulmonary rehabilitation4

Therapy16

Symptom2

Hypotension1

Shortness2

Significantly4

Scale1

Severity4

Symptomatic1

Diagnosis1

Acute8

Patient's1

Change from baseline2

Decrease2

Dosage and Administration1

Efficacy4

Chest1

Discontinue1

Quality of L4

Median5

Metastatic4

Dizziness2

Commonly2

Mortality4

Coronary artery2

Tiotropium1

Clinically3

Cohort1

Analyses1

Study18

Functional1

Diabetes mellitus1

Anxiety1

Forced expira1

Populations2

Subjective2

Complications4

Operable disease1

Significant4

Function2

Infection1

Heart failure5

Hypertension4

Adverse2

Regimen2

Multiple myeloma2