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  • Procedure
  • One of his major contributions was the development of the regimen to prepare patients for the procedure by using the anticancer drugs busulfan and cytoxan, which quickly became the worldwide standard. (wikipedia.org)
  • Following the transplant procedure, the patient's CD4+ T-cells circulating in the blood were homozygous for CCR5-Δ32. (wikipedia.org)
  • The text read: "Dr. Gero Hütter: In recognition of your historic achievement of being the first doctor to functionally cure AIDS/HIV through an innovative procedure that entails a remarkable example of the use of stem cell transplants. (wikipedia.org)
  • When a splenectomy is scheduled, JMML patients are advised to receive vaccines against Streptococcus pneumoniae and Haemophilus influenza at least 2 weeks prior to the procedure. (wikipedia.org)
  • GVHD
  • GVHD prophylaxis: Patients receive cyclosporine orally or IV over 2-4 hours twice daily beginning on day -1 followed by a taper starting on day 30 (BuFluATG conditioning) or day 60 (BuCy conditioning). (bioportfolio.com)
  • Patients receive tacrolimus IV continuously or orally twice daily beginning on day -2 and continuing up to day 44-100 in the absence of GVHD. (clinicaltrials.gov)
  • Donor lymphocyte infusion: Patients with partial or complete T-cell chimerism receive up to 3 donor lymphocyte infusions in the absence of GVHD or progressive disease. (clinicaltrials.gov)
  • Mutation
  • The physicians found a bone marrow donor with a CCR5-Δ32 mutation in both genomic copies of a gene encoding a cell-surface chemokine receptor called CCR5. (wikipedia.org)
  • This includes: 15-20% of patients with neurofibromatosis 1 (NF1) 25% of patients with mutations in one of the RAS family of oncogenes (only in their leukemia cells) Another 35% of patients with a mutation in a gene called PTPN11 (again, only in their leukemia cells). (wikipedia.org)
  • Phase
  • ViroPharma Incorporated (Nasdaq: VPHM) announced the publication of results of its previously described Phase 2 study showing that maribavir, when used as prophylaxis, reduced the rate of cytomegalovirus (CMV) reactivation and was well tolerated when compared to placebo in allogeneic stem cell , or bone marrow , transplant patients. (medicalnewstoday.com)
  • While this dose-ranging study evaluated the safety and the ability of maribavir to prevent viral reactivation in bone marrow transplant patients, we are particularly encouraged by the possibility that maribavir may help reduce the rate of CMV disease and associated morbidity, something we are investigating in our current Phase 3 study," said Stephen Villano, M.D., vice president, clinical research and development at ViroPharma. (medicalnewstoday.com)
  • lymph
  • However, the patient actually had a brain biopsy, in addition to biopsies of his intestines, liver, lymph nodes, bone marrow-basically, every part of the body that can be biopsied. (wikipedia.org)
  • infection
  • The trial will evaluate the safety and efficacy of letermovir antiviral treatment of active cytomegalovirus infection or cytomegalovirus disease in patients with infections that are refrac. (bioportfolio.com)
  • Impact of Cytomegalovirus Infection on the Outcome of Patients With Cirrhosis: A Preliminary Study. (bioportfolio.com)
  • The aims of this study were to evaluate whether cytomegalovirus (CMV) infection is associated with hepatocellular carcinoma (HCC) and liver-related mortality in cirrhotic patients. (bioportfolio.com)
  • Cytomegalovirus retinitis is a major opportunistic infection in AIDS patients and can cause blindness. (bioportfolio.com)
  • Patients with current life-threatening infection at time of transplant that would preclude a transplant are excluded. (clinicaltrials.gov)
  • In the March 10, 2011, issue of the medical journal Blood, Huetter wrote, "it is reasonable to conclude that cure of HIV infection has been achieved in this patient. (wikipedia.org)
  • C. jeikeium is pathogenic, typically causing an opportunistic infection seen most frequently in bone marrow transplant patients. (wikipedia.org)
  • A weakened immune system leaves patients susceptible to different kinds of infection. (wikipedia.org)
  • By providing the child and the parents with infection free accommodation and the necessary nutritional support, St. Judes makes a crucial intervention leading to the child's recovery and a noticeable increase in the survival rates of child patients with cancer. (wikipedia.org)
  • Myelodysplastic
  • Other conditions treated with stem cell transplants include sickle-cell disease, myelodysplastic syndrome, neuroblastoma, lymphoma, Ewing's sarcoma, desmoplastic small round cell tumor, chronic granulomatous disease and Hodgkin's disease. (wikipedia.org)
  • methotrexate
  • Giving cyclosporine and methotrexate before and after transplant may stop this from happening. (bioportfolio.com)
  • Patients also receive leucovorin calcium orally or IV over 4 hours after IT methotrexate and then once every 6 hours for a total of 8 doses after each dose of IT methotrexate. (bioportfolio.com)
  • viral
  • A study of intestinal disease in the UK, published in 1999, determined incidence as 3.8/1000 patient years in the community (95% CI, range 2.3-6.4), the fourth most common known cause of viral gastroenteritis. (wikipedia.org)
  • Patients die due to bacterial or viral infections. (wikipedia.org)
  • efficacy
  • To provide ganciclovir on a compassionate use basis to immunocompromised patients with serious cytomegalovirus (CMV) infections and to study safety and efficacy in this patient population. (bioportfolio.com)
  • candidates
  • Patients who are candidates will be evaluated for HTLV III activity and drug levels. (clinicaltrials.gov)
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)