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  • Smad
  • In this review, we focus on ERK, JNK, p38 and ERK5, the major MAPKs, and their interactions with PI3K-Akt, TGFβ/Smad and Wnt/β-catenin pathways. (mdpi.com)
  • kinase
  • Study of the transcriptional activity of Rlm1p, which is under the control of Mpk1p, the last kinase of the PKC pathway, and follow-up of the PST1 transcription, which is positively regulated by Rlm1p, indicate that the lack of RGD1 function diminishes the PKC pathway activity. (sdbonline.org)
  • receptors
  • However, individual Wnts and Fzs can activate both β-catenin-dependent and -independent pathways, and Fz co-receptors such as LRP probably provide some of this specificity. (biologists.org)
  • regulation
  • Depletion of G3BP2, chemical inhibition of protein methyl transferase activity, and expression of methylation-deficient G3BP2 attenuated Wnt3a-induced LRP6 phosphorylation, revealing previously unknown modes of regulation of the Wnt pathway. (biologists.org)
  • several
  • 3 , 4 Aberrations in this pathway have been implicated in several human malignancies including, but not limited to, colorectal cancer, prostatic cancer, hepatocellular cancer, lung cancer, breast cancer, and melanoma. (pubmedcentralcanada.ca)
  • growth
  • The main functions assigned to these GTPases involve bud formation and cell surface growth, which might occur through the involvement of the actin cytoskeleton and the secretory pathway. (sdbonline.org)
  • human
  • Secreted human β isoform (teratocarcinoma derived) autotaxin with C-terminal 6-His tag was expressed in Sf9 cells and purified using nickel-NTA chromatography. (echelon-inc.com)
  • different
  • The relative importance of different parallel pathways, however, remains inadequately understood and quantified. (jove.com)