Pathways regulating the differentiation at transcription. Medical search. Frequent questions

Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
2. We recently identified a novel PDX1 stress inducible complex (es) positioned over CARE sites and involving ATF4 and ATF5 that regulates expression of stress and apoptosis genes to govern β cell survival. (upenn.edu)
MAPK3 also phosphorylates other kinases, such as p90RSK, which further propagate the signal to regulate cellular processes like cell cycle progression, apoptosis, and differentiation. (creativebiomart.net)
Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
This protein is involved in different signaling pathways and in basic cellular functions, such as DNA repair, cell growth, differentiation, apoptosis, and tumor suppression. (medscape.com)
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)

16 Among these loci, "son of sevenless homologue 1" ( SOS1 , OMIM 182530) and "RE1 silencing transcription factor" ( REST , OMIM 600571), which are HGF-related pathogenic genes, have been identified as associated with GINGF1 and GINGF5, respectively. (nature.com)
Other examples of Drosophila gene complexes include the Antennapedia complex (ANTP-C), the bithorax complex (BX-C) and the achaete-scute complex (AS-C). The hallmark of all these gene complexes, including the E(spl)-C is that within any complex the genes are evolutionarily related and jointly regulated. (sdbonline.org)
Genes of the E(spl)-C and AS-C regulate neurogenesis and related differentiation pathways. (sdbonline.org)
For example, the AS-C transcription factors activate transcription of other genes, while the transcription factors of the E(spl)-C repress transcription. (sdbonline.org)
It seems that the expansion of numbers of genes evolving by duplication to handle the ever increasing complexities of neurogenesis, has been matched by a similar expansion of genes, also by duplication, to suppress or regulate neurogenesis. (sdbonline.org)
Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su[H]) to mediate transcription of target genes. (sdbonline.org)
All three genes depend on Su(H) for initiation and/or maintenance of transcription. (sdbonline.org)
The expression patterns suggest that both genes are under the same regulatory control as are the E(spl) bHLH genes and thus, might play a part in Notch mediated cell differentiation. (sdbonline.org)
These events are dependent on the proper levels of transcription and translation of certain genes. (cancerquest.org)
Similarly, the single-cell assay for transposase-accessible chromatin sequencing showed increased chromatin accessibility at genes associated with myeloid differentiation, including CD11b, CD11c, and IRF8. (nih.gov)
NICD translocates into the nucleus and initiates transcription of Notch-responsive genes (4). (novusbio.com)
The results showed that USF1 significantly regulates 350 differentially expressed genes (DEGs). (spandidos-publications.com)
The upregulated DEGs were primarily protein‑coding genes enriched in immune and inflammation response pathways, while the downregulated DEGs were mainly coding long non‑coding (lnc)RNAs, indicating the regulatory function of USF1. (spandidos-publications.com)
It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
Downstream genes, including lncRNA‑NEAT1 and TF‑ETV5, may also have potential functions in the regulated network by USF1 and have potential functions in the progression of HCC. (spandidos-publications.com)
As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
A total of 7,928 SDE genes and 46 canonical pathways derived from it were identified. (frontiersin.org)
Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
fd3F regulates genes required for specialized aspects of chordotonal dendrite physiology. (tcd.ie)
Ligand-activation of the hybrid receptor will not induce collateral expression of target genes that are otherwise regulated by the native nuclear receptor. (indigobiosciences.com)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
Induces upregulation of the pluripotency network genes (Klf4, Klf2, Nanog, Oct4, Myc, Sox2) and epigenetic-associated proteins (Dnmt3a, Mbd3) in mouse ES cells, and inhibits retinoic acid-induced differentiation (Adamo et al. (stemcell.com)
Results from RNA sequencing revealed that AEG‑1 modulated neuronal morphology and development by regulating the expression of numerous genes, such as ubiquitin C, C‑X‑C motif chemokine ligand 1, MMP9, Notch1, neuropilin 1 and ephrin type‑A receptor 4. (spandidos-publications.com)

Transcription factor Sp2 promotes TGFB-mediated interstitial cell osteogenic differentiation in bicuspid aortic valves through a SMAD-dependent pathway. (nih.gov)
Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
Inhibits proliferation and promotes osteogenic differentiation, while inhibiting adipogenic differentiation, of human amnion-derived mesenchymal stem cells (MSCs) and rabbit bone marrow-derived MSCs (Wu et al. (stemcell.com)
Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs. (bvsalud.org)
hBMSC cells can promote osteogenic differentiation. (bvsalud.org)
The purpose of this study was to elucidate the mechanism by which ASCL1 promotes osteogenic differentiation in hBMSC cells while decreasing glycolysis . (bvsalud.org)
The ASCL1 expression level during hBMSC osteogenic differentiation was measured by RTâ qPCR, Western blotting , and immunofluorescence . (bvsalud.org)
Overexpression of ASCL1 was used to determine its impact on osteogenic differentiation. (bvsalud.org)
si-USP8 was used to verify the ubiquitination of ASCL1-mediated CD47/AKT pathway's impact on hBMSC glycolysis and osteogenic differentiation. (bvsalud.org)
The results showed that the expression of ASCL1 was upregulated after the induction of osteogenic differentiation in hBMSCs. (bvsalud.org)
From a functional perspective, knocking down USP8 can promote the ubiquitination of ASCL1, while the osteogenic differentiation ability of hBMSCs was improved after the overexpression of ASCL1, indicating that ASCL1 can promote the osteogenic differentiation of hBMSCs. (bvsalud.org)
In addition, USP8 regulates the ubiquitination level of ASCL1 and mediates CD47 transcriptional regulation of the AKT pathway to increase the glycolysis level of hBMSCs and cell osteogenic differentiation. (bvsalud.org)
In addition, ubiquitination of ASCL1 mediates CD47 transcription to activate the AKT signaling pathway and increase hBMSC glycolysis to promote osteogenic differentiation. (bvsalud.org)

through the coordinated actions of several transcription factors (TFs) In this study, we examined the dynamics of several key transcription factors (TFs) - PPARγ, C/EBPβ, CREB, NFAT, FoxO1, and SREBP-1c - during adipogenic differentiation (week 1) and ensuing lipid accumulation. (tufts.edu)
The activation profiles of these TFs at different times following induction of adipogenic differentiation were quantified using 3T3-L1 reporter cell lines constructed to secrete the Gaussia luciferase enzyme upon binding of a TF to its DNA binding element. (tufts.edu)

JOA displayed the activity of inhibiting the BCR-ABL and promoted differentiation of not only imatinib -sensitive but also imatinib -resistant cells with BCR-ABL mutation, which could become a potent lead compound to overcome the imatinib -resistant induced by inhibitors of BCR-ABL tyrosine kinase in CML therapy. (jcancer.org)
BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
MAPK3, also known as ERK1 (Extracellular Signal-Regulated Kinase 1), is a serine/threonine kinase involved in cell signaling pathways. (creativebiomart.net)
MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. (nih.gov)
MAPK1 (ERK2) is a serine/threonine kinase that acts as an important activator of p90 RSK, MSK, ELK1, and Stat3, and is involved in the MAPK pathway. (thermofisher.com)
However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

In addition, due to the importance of macrophage in mediating inflammatory response, including TNF production, and the proposed role of tumor-associated macrophage (TAM) in tumorigenesis, an understanding of monocyte/macrophage differentiation will help us to understand the mechanism of inflammation-mediated tumor development. (nih.gov)
By modulating these signaling pathways, cytokine receptors help coordinate immune responses, inflammation, and other physiological processes. (indigobiosciences.com)
However, upon exposure to inflammatory stimuli, they also initiate and amplify type 2 inflammation by inducing mucus production, eosinophilia, and Th2 differentiation. (broadinstitute.org)
Moreover, other lipid messengers, including palmitoylethanolamide (PEA) and oleoylethanolamide (OEA) can regulate lipid metabolism, skin cell proliferation/differentiation and inflammation by engaging ligand-activated transcription factors such as peroxisome proliferator-activated receptors (PPARs). (scienzainrete.it)
Activation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) modulates lipid and glucose homeostasis, cell proliferation and differentiation, and inflammation. (cdc.gov)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)

This activation triggers intracellular signaling pathways, which can involve various molecules such as kinases, transcription factors, and secondary messengers. (indigobiosciences.com)

Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro. (nih.gov)
Changes in the differentiation potential of MSCs after in vitro expansion were noted and chondrogenic clones especially disappeared early on [ 12 ]. (hindawi.com)
Inhibition of EHMT2 expression or activity in human ERMS cell lines reduced DKK1 expression and elevated canonical Wnt signaling resulting in myogenic differentiation in vitro and in mouse xenograft models in vivo. (elifesciences.org)

The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)

In the field of developmental biology, regional differentiation is the process by which different areas are identified in the development of the early embryo. (wikipedia.org)
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Aberrant reactivation of developmental pathways is evident in IPF. (lu.se)

ZNF513 combined with KIF3C regulates gingival fibroblast proliferation, migration, and fibrosis response via the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK pathways. (nature.com)

Krüppel-like factors can bind to specific DNA motifs and regulate various cellular functions, such as metabolism, cell proliferation, and differentiation. (medsci.org)

Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation. (tufts.edu)
Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)

Firstly, atonal directly regulates Rfx, a well-known highly conserved ciliogenesis transcriptional regulator. (tcd.ie)
Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [ 1 , 2 ]. (medsci.org)
Human INT1 has been found to be very similar to mouse INT1, thus most revealing the highly conserved nature of this pathway across species [3]. (chemdiv.com)

The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)

Methylated DNA can prevent transcription factors from binding to it, resulting in low or no gene expression, which is an important alteration in the early initiation and development of malignant neoplastic diseases [ 7 ]. (hindawi.com)
It phosphorylates various transcription factors, including ELK1 and c-Fos, leading to changes in gene expression. (creativebiomart.net)
KLF6 downregulation enhances MDM2 gene expression that deregulates the p53 pathway [ 9 ]. (medsci.org)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
CBP has significant histone acetyltransferase activity and "opens" the chromatin structure so that transcription factors can enter and regulate gene expression. (medscape.com)

Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)

Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)

Ly6C high MC presented downregulated co-stimulatory receptors (CD2, GITR, and TIM1) which direct immune cell proliferation, and upregulated co-stimulatory ligands (LIGHT and SEMA4A) which trigger antigen priming and differentiation. (frontiersin.org)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
A committee of experts, initially sponsored by the World Health Organization (WHO), meets every 2 years with the goal to classify the group of primary immunodeficiency diseases according to current understanding of the pathways that become defective in the immune system. (medscape.com)

Understanding on a molecular level the underlying regulatory pathways and the synergistic action of transcription factors is of broad interest for cardiovascular biologist, as it opens the perspective to influence cardiac growth and stimulate cardiac regeneration. (europa.eu)
Better understanding of the cellular and molecular pathophysiological mechanisms regulating adipocyte size, number and depot-dependent expansion has become a focus of interest over recent decades. (springer.com)
Reduced number and function of insulin-secreting beta cells underlies the progression of all forms of diabetes, underscoring the translational relevance of deciphering molecular pathways regulating the formation, growth, and function of beta cells. (upenn.edu)
Our current efforts on this project are directed at (1) determining the mechanisms whereby Pdx1 and Oc1 cooperate to establish a chromatin landscape permissive for endocrine differentiation and proliferation, (2) Defining the roles of the Pdx1 and Oc1 IDPRs in protein-protein interaction and endocrine differentiation, and (3) Defining the molecular mechanisms by which the Pdx1 C-terminal domain regulates protein stability and function during pancreas organogenesis and endocrine differentiation. (upenn.edu)
In the last 4 years, we have made several significant contributions towards a better understanding of the molecular mechanism regulating TNF signaling and macrophage differentiation. (nih.gov)
Some molecular pathways required for SHF development in birds and mammals are conserved in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp signaling in the zebrafish heart fields. (duke.edu)
These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)

AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling). (stemcell.com)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
Conclusions Our findings suggest that DIM may improve insulin sensitivity through the activation of the insulin signaling pathway, leading to enhanced glucose uptake. (researchgate.net)
3,3′-diindolylmethane (DIM)-a natural compound produced from indole-3-carbinol, found in cruciferous vegetables-enhances glucose uptake by increasing the activation of the insulin signaling pathway in 3T3-L1 adipocytes. (researchgate.net)
Besides, overexpression of miR-128-3p downregulated TGFBR2 to suppress the activation of the Smad signaling pathway. (degruyter.com)
In this review, we discuss the regulation of ILC2 activation by transcription factors and metabolic pathways, as well as by extrinsic signals such as cytokines, lipid mediators, hormones, and neuropeptides. (broadinstitute.org)
Wound healing is a dynamic process involving the activation of intracellular pathways which need to be coordinated to restore the integrity of the injured tissue. (scienzainrete.it)
Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)

Many cell fate decisions in higher animals are based on intercellular communication governed by the Notch signaling pathway. (sdbonline.org)
Thus Notch acts as both a ligand-binding receptor and a nuclear factor that regulates transcription. (novusbio.com)
this included the TNF‑α pathway, the NF‑κB pathway, the MAPK signaling pathway, the Notch signaling pathway and Axon guidance. (spandidos-publications.com)
The Notch signaling pathway is involved in several lineage commitment and differentiation events. (lu.se)
Here, we report that Notch signaling also modulates the function of the transcription factor, early B-cell factor (EBF). (lu.se)

MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
This includes altered expression of histone deacetylases, methyltransferases as well as lncRNAs and microRNAs that inhibit differentiation. (elifesciences.org)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (thermofisher.com)

ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
In addition, it provides a paradigm for how transcriptional regulation may modulate the ciliogenesis pathway to give rise to structurally and functionally specialised ciliary dendrites. (tcd.ie)
Studying the regulation of monocyte/macrophage differentiation and the role of tumor-associated macrophage in tumorigenesis. (nih.gov)
Investigating the regulation of monocyte/macrophage differentiation. (nih.gov)
These new findings suggest new roles for L1 in the mechanism of cortical dendrite differentiation, as well as in guidance of callosal axons and regulation of hippocampal development. (jneurosci.org)
Collectively, the present study provides insights into AEG‑1‑dependent gene regulation and signaling pathway transduction in neurons. (spandidos-publications.com)
Transient transfection of intracellular Notch1 (Notch1-IC) into a pre-B cell line resulted in the down-regulation of EBF-regulated promoters and diminished the capacity of EBF to activate these promoters in an epithelial cell line. (lu.se)

This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. (nih.gov)
All are basic helix-loop-helix transcription factors. (sdbonline.org)
Mechanistically, Acly deficiency altered chromatin accessibility and expression of multiple C/EBP family transcription factors known to regulate myeloid differentiation and cell metabolism, with increased Cebpe and decreased Cebpa and Cebpb. (nih.gov)
The transcription factors TBX5 and Nkx2.5 both play central roles in cardiac development. (europa.eu)
SRY-related high-mobility-group box 9 (SOX9) is a member of the SOX family of transcription factors. (cancerindex.org)
MAPK3 plays a crucial role in regulating cell proliferation, differentiation, and survival by phosphorylating downstream targets such as transcription factors and other kinases. (creativebiomart.net)
In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. (tcd.ie)
Whilst the role of proneural factors in fate specification is well studied, the link between neural specification and the cellular pathways that ultimately must be activated to construct specialised neurons is usually obscure. (tcd.ie)
Our analysis demonstrates how early cell fate specification factors can regulate structural and physiological differentiation of neuronal cell types. (tcd.ie)
It also suggests a model for how subtype differentiation in different neuronal lineages may be regulated by different proneural factors. (tcd.ie)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)
YT do not have a DNA binding domain but act through interaction with other transcription factors (TFs). (lu.se)

3. We hypothesize that PDX1-Onecut1 (OC1) interactions, in part mediated by their intrinsically disordered protein regions (IDPRs), regulate Pdx1 stability, cell cycle progression, and pancreatic endocrine differentiation during development. (upenn.edu)

Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

In addition, we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1 . (nature.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)
Finally, we found that PAK3 regulated EMT-related molecule expression and EMT-related TGF-β/smad signaling pathway. (jcancer.org)
High expression of PAK3 enhances the invasion of HCC and regulates EMT, suggesting that PAK3 may be a potential target for the treatment of HCC. (jcancer.org)
KLF6 functions as a tumor suppressor gene and increases p21 expression via p53-independent pathway [ 3 ]. (medsci.org)
Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
In CaCo-2 colonic epithelial cells, the expression of this gene increases with cell differentiation. (aacrjournals.org)
Accordingly, the expression of human HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. (aacrjournals.org)
HMGCS2 protein expression is down-regulated preferentially in moderately and poorly differentiated carcinomas. (aacrjournals.org)
Using real-time, quantitative PCR, laser capture microdissection, and immunohistochemistry, distinctive patterns of expression of the hedgehog pathway members patched 1 (PTCH1), smoothened, GLI1, GLI2 and the 3 hedgehog ligands were identified for epithelial cells and stromal fibroblasts in benign breast and breast cancer. (rti.org)
Hedgehog-mediated transcription, as indicated by a reporter of GLI-dependent promoter activity and by expression of GLI1 transcripts, was reduced by the hedgehog pathway inhibitor cyclopamine in both MDA-MB-435 cancer epithelial cells and MCF10AT epithelial cells, a cell line derived from benign breast. (rti.org)
Decreased proliferation and Nanog expression in mouse embryonic stem (ES) cells, with increased erythroid differentiation (Chae et al. (stemcell.com)
In addition, upregulation of AEG-1 expression can protect nigral dopaminergic neurons from injury caused by aberrant apoptotic signaling pathways ( 13 ). (spandidos-publications.com)
As human PPAR alpha expression is significantly less than that of rodents, potential PPAR alpha independence indicates that future research must explore mechanisms of action of these compounds, including PPAR alpha-dependent and -independent pathways. (cdc.gov)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

Acly inhibition thus can promote myelopoiesis through deprivation of acetyl-CoA and altered histone acetylome to regulate C/EBP transcription factor family activity for myeloid differentiation. (nih.gov)
Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF-MEK-ERK1/2 pathway inhibition. (babraham.ac.uk)

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is a potential regulatory point in the pathway that converts acetyl-CoA to ketone bodies ( 1 - 3 ). (aacrjournals.org)

The hedgehog pathway regulates epithelial-mesenchymal interactions, differentiation, proliferation and survival during development. (rti.org)
These results demonstrate modulation of GLI-mediated transcription in both cancer and benign-derived epithelial cells by cyclopamine and sonic hedgehog, and further suggest that hedgehog signaling contributes to the survival of only the cancer epithelial cells. (rti.org)

In this study, we demonstrate that ATP citrate lyase (Acly), which metabolizes citrate to generate cytosolic acetyl-CoA and is of clinical interest, can regulate chromatin accessibility to limit myeloid differentiation. (nih.gov)
Treatments increased the abundance of cell populations that expressed the myeloid integrin CD11b and other markers of myeloid differentiation. (nih.gov)
The bias to myeloid differentiation appeared due to insufficient generation of acetyl-CoA, as exogenous acetate to support alternate compensatory pathways to produce acetyl-CoA reversed this phenotype. (nih.gov)

They are broadly expressed in the heart, where they act synergistically on many promoters (i.e. the atrial natriuretic peptide (ANF) promoter) to regulate growth and differentiation of the cardio-vascular system. (europa.eu)
For instance, a previous study by the authors validated that USF1 binds to the core promoter of APOBEC3G and increases its transcription level in hepatocytes ( 7 ). (spandidos-publications.com)

A crystal that diffracted to 1.9 Å contained monomeric Tbx5 in the DNA-free form, which is the first structure of a DNA-free T-box transcription factor. (europa.eu)
Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
The homeodomain transcription factor Pdx1 is a critical member of the beta cell transcriptional network during embryonic beta cell formation and in postnatal beta cell function. (upenn.edu)
In contrast, fd3F encodes a novel forkhead family transcription factor that is exclusively expressed in differentiating chordotonal neurons. (tcd.ie)
Tumor necrosis factor (TNF) is a proinflammatory cytokine that plays a critical role in diverse cellular events, such as cell proliferation, differentiation and cell death. (nih.gov)
I show that this field expresses Isl1, a transcription factor associated with the SHF in other species. (duke.edu)
Additionally, the transcription factor Tbx1 and the Sonic hedgehog pathway are necessary for normal development of the zebrafish arterial pole. (duke.edu)
Such effects are primarily, albeit not exclusively, due to the ability of PEA and OEA to engage the ligand-activated transcription factor, peroxisome proliferator-activated receptor-α (PPAR-α), to which they bind with high affinity. (scienzainrete.it)

Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)

In addition to these intermediate transcriptional regulators, we show that atonal directly regulates a novel gene, dilatory, that is directly associated with ciliogenesis during neuronal differentiation. (tcd.ie)

White adipose tissue (WAT) has key metabolic and endocrine functions and plays a role in regulating energy homeostasis and insulin sensitivity. (springer.com)

This study aims to explore molecule signaling mediating MC subset differentiation in HHcy and control mice. (frontiersin.org)

The only important role of β-catenin is to activate the transcription of the gene Pmar1. (wikipedia.org)

The mutant proteins often retain some of their capabilities but are no longer sensitive to the controls that regulate the normal form of the protein. (cancerquest.org)

We further found the Hippo pathway to be dysregulated in the fibrotic lung epithelium which led to increases in nuclear YT as well as known downstream targets. (lu.se)
Right now, the most common theory is that the disease could potentially be triggered by an initial injury to the lung epithelium which in turn induces an abnormal repair pathway, leading to d amage of the lung. (lu.se)

Specification is the first stage in differentiation. (wikipedia.org)

In biological English, the term regulate is narrowed to refer only to the suppression of neurogenesis. (sdbonline.org)
Studies from many laboratories have demonstrated that the diverse TNF-mediated biological responses are achieved through activating multiple signaling pathways. (nih.gov)

Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)

ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled? (babraham.ac.uk)
The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. (babraham.ac.uk)

Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2 . (aacrjournals.org)

Promotes differentiation and mineralization of MC3T3-E1 osteoblastic cells (Kanazawa et al. (stemcell.com)

to other RNAs may initiate epige- cleus pathways. (who.int)

In addition, AEG-1 as a key modulator regulates aberrant cellular processes within the central nervous system (CNS), where it is involved in neurological diseases such as Huntington's chorea, migraine and HIV-induced neurological disorders ( 7-9 ). (spandidos-publications.com)

Hematopoiesis integrates cytokine signaling, metabolism, and epigenetic modifications to regulate blood cell generation. (nih.gov)

Anatomy32

Organisms9

Diseases1

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes77

Disciplines and Occupations3

Information Science4

Apoptosis8

Indicating that USF1

Genes25

Osteogenic differentiation14

Adipogenic differentiation2

Kinase7

Inflammation6

Intracellular signalin1

Vitro3

Mediates1

Developmental4

Migration1

Cellular functions1

Adipocyte differentiation2

Highly conserved3

Mesenchymal stem1

Gene expression6

Canonical1

Proliferation and differentiation2

Immune5

Molecular7

Lipid and glucose1

Activation8

Notch5

MicroRNAs3

Extracellular1

Regulation7

Factors12

Progression1

Metastasis1

Expression15

Inhibition3

Regulatory1

Survival2

Myeloid3

Promoter2

Factor8

MiRNAs1

Neuronal1

Homeostasis1

Molecule1

Activate1

Proteins1

Epithelium2

Specification1

Biological2

Mechanism1

ERK12

Metabolic1

Promotes1

RNAs1

Aberrant1

Epigenetic1